Kinase Family GASK
From WikiKinome
Kinase Classification: Group Atypical: Family FJ
The FJ kinases are a recently-emerging family of atypical PKL-fold kinases which function in the Golgi to phosphorylate secreted proteins and sugar residues on glycoproteins and are sometimes secreted. The founding member, Drosophila four-jointed phosphorylates a cadherin substrate on the extracellular domain and is implicated in planar cell polarity.
Distinct subfamilies, Kinase_Subfamily_FJ, FAM20AC and FAM20B are found in bilaterian animals and some in lower animals, and unclassified homologs have also been found in Trypanosomes.
