Difference between revisions of "Kinase Family Trbl"

Revision as of 17:25, 11 February 2017

Kinase Classification: Group CAMK: Family Trbl

Trbl ("tribbles") is a family of pseudokinases involved in protein interactions and ubiquitination.

Evolution

Trbl is found throughout animals. Nematodes have a highly divergent member, originally classified as Other-Unique. Vertebrates have 3, TRBL1, TRBL2, TRBL3.

Domain Structure

Trbl has a divergent kinase domain, followed by a COP1 degron, and a unique C-terminal tail.

Functions

Modulation of CEBP function is conserved in C. elegans, helping to define the highly divergent gene nipi-3 (K09A9.1) as a member of the Trbl family [1, 2].

References

1. Kim KW, Thakur N, Piggott CA, Omi S, Polanowska J, Jin Y, and Pujol N. Coordinated inhibition of C/EBP by Tribbles in multiple tissues is essential for Caenorhabditis elegans development. BMC Biol. 2016 Dec 7;14(1):104. DOI:10.1186/s12915-016-0320-z | PubMed ID:27927209 | HubMed [Kim]
2. McEwan DL, Feinbaum RL, Stroustrup N, Haas W, Conery AL, Anselmo A, Sadreyev R, and Ausubel FM. Tribbles ortholog NIPI-3 and bZIP transcription factor CEBP-1 regulate a Caenorhabditis elegans intestinal immune surveillance pathway. BMC Biol. 2016 Dec 7;14(1):105. DOI:10.1186/s12915-016-0334-6 | PubMed ID:27927200 | HubMed [McEwan]