Difference between revisions of "Kinase Group AGC"
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This is a stub for the AGC group page. Please register and edit if you feel you can improve this (which you almost certainly can!). | This is a stub for the AGC group page. Please register and edit if you feel you can improve this (which you almost certainly can!). | ||
| + | The AGC group is named after the protein kinase A, G, and C families (PKA, PKC, PKG) which have a long history as cytoplasmic serine/threonine kinases that are regulated by secondary messengers such as cyclic AMP (PKA) or lipids (PKC) | ||
===[[PKA]]=== | ===[[PKA]]=== | ||
| − | Protein Kinase A/ cyclic AMP-dependent protein kinase. | + | Protein Kinase A/ cyclic AMP-dependent protein kinase. Multiple members found in all eukaryotic kinomes |
===[[PKC]]=== | ===[[PKC]]=== | ||
Revision as of 22:46, 2 August 2006
This is a stub for the AGC group page. Please register and edit if you feel you can improve this (which you almost certainly can!). The AGC group is named after the protein kinase A, G, and C families (PKA, PKC, PKG) which have a long history as cytoplasmic serine/threonine kinases that are regulated by secondary messengers such as cyclic AMP (PKA) or lipids (PKC)
Contents
PKA
Protein Kinase A/ cyclic AMP-dependent protein kinase. Multiple members found in all eukaryotic kinomes
PKC
Protein Kinase C. This is a large family with several subfamilies that are responsive to lipid signaling.
PKG
Protein Kinase G.
PKN
Protein Kinase N.
PDK1
AKT and SGK
RSK and RSKL
Ribosomal protein S6 Kinases. RSKL is a poorly-examined family whose sequences are quite close to RSK.
GRK
G-protein-coupled receptor kinases. As the name replies, they modulate GPCRs, including the rhodopsin light-sensitive GPCR, and a variety of neurotransmitter receptors.
NDR and MAST
DMPK
YANK
A family about which so little is known, it stands for "Yet Another Novel Kinase". Interestingly, flies and worms have YANK kinases as well as vertebrates, so while it's little known, it's clearly essential to metazoan living.
