Kinase Group CMGC
Kinase Classification: CMGC Group
The CMGC group (named after the initials of some members) includes key kinases: the MAPK growth- and stress-response kinases, the cell cycle CDK (cyclin dependent kinases) and kinases involved in splicing and metabolic control.
Evolution
This is an ancient group, with several families found in most or all eukaryotes.
Families
There are 9 highly-conserved CMGC families:
CDK: Cyclin Dependent Kinases
CDKL: CDK-like Kinases
CK2: Cell Kinase 2 (Casein Kinase 2)
CLK
DYRK
GSK: Glycogen Synthase Kinase
MAPK: Mitogen-Activated Protein Kinase
These are the final kinases in the MAPK cascade that couples extracellular signals including growth factors and stress signals to transcriptional and other responses. The Erk subfamily is growth-factor responsive and universal, with the stress responsive p38 and Jnk subfamilies mediate stress responses. Erk7 and nemo are additional specialized subfamilies that are less well studied.
