Kinase Group CMGC

Kinase Classification: CMGC

The CMGC group (named after the initials of some members) includes key kinases: the MAPK growth- and stress-response kinases, the cell cycle CDK (cyclin dependent kinases) and kinases involved in splicing and metabolic control.

Evolution

This is an ancient group, with several families found in most or all eukaryotes.

Families

There are 9 highly-conserved CMGC families:

CDK: Cyclin Dependent Kinases

===CDKL: CDK-like Kinases

===CK2: Cell Kinase 2 (Casein Kinase 2)

===CLK:

===DYRK

===GSK: Glycogen Synthase Kinase

===Kinase_Family_MAPK: Mitogen-Activated Protein Kinase

===RCK

===SRPK: SR-rich protein kinase