Difference between revisions of "Kinase Subfamily AlphaK1"
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====Functions==== | ====Functions==== | ||
| − | ALPK1 has been implicated in vesicle transport from the Golgi to the plasma membrane <cite>Heine</cite>, perhaps by myosin phosphorylation. Mouse ALPK1 mutants were associated with motor co-ordination defects <cite>Chen</cite>, and the gene has been associated with both gout and kidney disease. | + | ALPK1 has been implicated in vesicle transport from the Golgi to the plasma membrane <cite>Heine</cite>, perhaps by myosin phosphorylation. Mouse ALPK1 mutants were associated with motor co-ordination defects <cite>Chen</cite>, and the gene has been associated with both gout and kidney disease. Human ALPK1 has also been shown to be a receptor for the bacterial ADP-heptose<cite>Zhou</cite>. ADP-heptose binding causes ALPK1 to phosphorylate TIFA and activate NFkB signaling. |
====References==== | ====References==== | ||
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#Chen pmid=21208416 | #Chen pmid=21208416 | ||
#Heine pmid=15883161 | #Heine pmid=15883161 | ||
| + | #Zhou pmid=30111836 | ||
</biblio> | </biblio> | ||
Revision as of 22:40, 17 August 2018
Kinase Classification: Group PKL: Family Alpha: Subfamily AlphaK1
Domain Structure
Members have a 6-transmembrane-region TRPM channel followed by an alpha kinase domain.
Evolution
AlphaK1 (ALPK1) is a single-copy gene in vertebrates. Clear orthologs have also been detected in the chordate Branchiostoma floridae (lancelet) and the sea anemone, Nematostella, suggesting that the gene was born in early metazoan evolution, but then lost from many lineages.
Functions
ALPK1 has been implicated in vesicle transport from the Golgi to the plasma membrane [1], perhaps by myosin phosphorylation. Mouse ALPK1 mutants were associated with motor co-ordination defects [2], and the gene has been associated with both gout and kidney disease. Human ALPK1 has also been shown to be a receptor for the bacterial ADP-heptose[3]. ADP-heptose binding causes ALPK1 to phosphorylate TIFA and activate NFkB signaling.
References
- Heine M, Cramm-Behrens CI, Ansari A, Chu HP, Ryazanov AG, Naim HY, and Jacob R. Alpha-kinase 1, a new component in apical protein transport. J Biol Chem. 2005 Jul 8;280(27):25637-43. DOI:10.1074/jbc.M502265200 |
- Chen M and Xu R. Motor coordination deficits in Alpk1 mutant mice with the inserted piggyBac transposon. BMC Neurosci. 2011 Jan 5;12:1. DOI:10.1186/1471-2202-12-1 |
- Zhou P, She Y, Dong N, Li P, He H, Borio A, Wu Q, Lu S, Ding X, Cao Y, Xu Y, Gao W, Dong M, Ding J, Wang DC, Zamyatina A, and Shao F. Alpha-kinase 1 is a cytosolic innate immune receptor for bacterial ADP-heptose. Nature. 2018 Sep;561(7721):122-126. DOI:10.1038/s41586-018-0433-3 |
