Kinase Subfamily MOK

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Kinase Classification: Group CMGC: Family RCK: MOK


MOK is a primordial eukaryotic kinase, predicted to be in the last common ancestor of all eukaryotes. However, it has been lost from several lineages, including nematodes, insects, fungi, and higher plants. The single human member is called MOK (MAPK/MAK/MRK Overlapping Kinase), also known as RAGE1 (renal tumor antigen)

Domain Structure

All MOK kinases have an N-terminal kinase domain and a variable length (~100-300 AA) C-terminal tail without any known domains.


<to be added> Human MOK is expressed in cytoplasm and stained the Golgi in one cell line ( LF4 is a Chlamydomonas MOK which interacts genetically with LF2 (a CDK20 subfamily kinase) in regulating flagellum growth [1]. Mouse MOK is selectively expressed in intestinal epithelial cells, under the regulation of the Cdx2 homeodomain protein [2].

Human MOK specifically associates with the chaperones Hsp90 and Cdc37 [3]; phosphorylation of Cdc37 by CK2 was required for this association [4]


  1. Berman SA, Wilson NF, Haas NA, and Lefebvre PA. A novel MAP kinase regulates flagellar length in Chlamydomonas. Curr Biol. 2003 Jul 1;13(13):1145-9. DOI:10.1016/s0960-9822(03)00415-9 | PubMed ID:12842015 | HubMed [Berman]
  2. Uesaka T and Kageyama N. Cdx2 homeodomain protein regulates the expression of MOK, a member of the mitogen-activated protein kinase superfamily, in the intestinal epithelial cells. FEBS Lett. 2004 Aug 27;573(1-3):147-54. DOI:10.1016/j.febslet.2004.07.070 | PubMed ID:15327990 | HubMed [Uesaka]
  3. Miyata Y, Ikawa Y, Shibuya M, and Nishida E. Specific association of a set of molecular chaperones including HSP90 and Cdc37 with MOK, a member of the mitogen-activated protein kinase superfamily. J Biol Chem. 2001 Jun 15;276(24):21841-8. DOI:10.1074/jbc.M010944200 | PubMed ID:11278794 | HubMed [Miyata2]
  4. Miyata Y and Nishida E. CK2 controls multiple protein kinases by phosphorylating a kinase-targeting molecular chaperone, Cdc37. Mol Cell Biol. 2004 May;24(9):4065-74. DOI:10.1128/mcb.24.9.4065-4074.2004 | PubMed ID:15082798 | HubMed [Miyata]
All Medline abstracts: PubMed | HubMed