Kinase classification

Protein Kinases have a wide variety of functions and can be classified by function and by the sequence similarity. We use a hierarchical system of classifying kinases into groups, which consist of multiple families, which sometimes have several subfamilies. Here we outline the 10 groups of protein kinases

Tyrosine Kinase (TK) This group phosphorylates almost exclusively on tyrosine residues, as opposed to most other kinases that are selective for serine or threonine

Tyrosine Kinase-Like (TKL) The group most similar to tyrosine kinases, but whose activities are generally on serine/threonin substrates.

AGC Named after the Protein Kinase A, G, and C families, these kinases mediate much of the basic intracellular signaling machinery.

CMGC Group contains cell cycle regulatory kinases (CDK), as well as the MAPK family, several families involved in splicing.