CLUSTAL Trio_Human ----MSGSSGGAAAPAASSGPAAAASAAGSGCGGGAGEGAEEAAKDLADIAAFFRSGFRK Trad_Human ----------------------------------MTDRFWDQWYLWYLRLLRLLDRGSFR Saccoglossus_kowalevskii ------------------------------------------------------------ Branchiostoma_floridae ------------------------------------------------------------ Strongylocentrotus_purpuratus ------------------------------------------------------------ Harpegnathos_saltator -----------------------------------------------------------M Apis_mellifera -----------------------------------------------------------M Bombus_terrestris -----------------------------------------------------------M Nasonia_vitripennis -------------------------------------------------MDNLRPLITKM Tribolium_castaneum -----------------------------------------------------------M Drosophila_melanogaster -----------------------------------------------------------M Drosophila_willistoni -----------------------------------------------------------M Drosophila_grimshawi -----------------------------------------------------------M Anopheles_gambiae -----------------------------------------------------------M Anopheles_aegypti ------------------------------------------------------------ Culex_quinquefasciatus -----------------------------------------------------------M Pediculus_humanus ------------------------------------------------------------ Ixodes_scapularis ------------------------------------------------------------ Caenorhabditis_elegans ------------------------------------------------------MGDYDG Caenorhabditis_briggsae ------------------------------------------------------------ Loa_loa ----------------------------------------------------------MR Brugia_malayi ----------------------------------------------------------MR Ascaris_suum -------------------------------------------------------MEEFH Schistosoma_mansoni QHTEHYHYHVNQNAYRSSVSPQNLGSTCGGSINALTSTSGVSSNSGSLCTSSSSHSSHKS Hydra_magnipapillata ------------------------MLKNSSSNSSERWSKASSDSDASFVSGSSSTSHGEH Nematostella_vectensis ------------------------------------------------------------ Trichoplax_adhaerens --------------------------------MAAGSLVAVNTLSDDDISKSLMELGTDE Trio_Human NDEMKAMDVLPILKEKVAYLSGGRDKRGGPILTFPARS-NHDRIRQEDLRRLISYLACIP Trad_Human NDGLKASDVLPILKEKVAFVSGGRDKRGGPILTFPARS-NHDRIRQEDLRKLVTYLASVP Saccoglossus_kowalevskii ------------------------------------------------------------ Branchiostoma_floridae ------------------------------------------------------------ Strongylocentrotus_purpuratus ------------------------------------------------------------ Harpegnathos_saltator D-GTRAAEVLPLLQERLAILPGGRDRRGGPVLLFPSTP-RRERAKPEDYRRLLQYLFAIP Apis_mellifera D-GTRAAEVLPLLQERLAILPGSRDRRGGPVLLFPTTP-RRERAKPEDYRRLLQYLLTVP Bombus_terrestris D-GTRATEVLPLLQERLAILPGGRDRRGGPVLVFPTTA-RRERAKPEDYRRLLQYLLTIP Nasonia_vitripennis D-IIRAAEVLPLLQERLAIMPGGRDRRGGLLLLFPTTP-RRERAKPEDYRRLLQYLMAIP Tribolium_castaneum D-GQRALELMPLLQERLVILTGGRDRRGGPVLSFPASP-RRERAKPEDYKRLLQYLMSIP Drosophila_melanogaster D-GQRARDLLTLLQERVVFLTGGRDRRGGPLLCFPATP-RRDRLKPEDLRRLLSYLISIP Drosophila_willistoni D-GQRARDLLTLLQERVVLLTGGRDRRGGPLLCFPATP-KRDRLKPEDLRRLLIYLISIP Drosophila_grimshawi D-GQRARDLMTLLQERVVFLTGGRDRRGGPLLCFPATP-RRDRLKPEDLRRLLSYLISIP Anopheles_gambiae D-GVRALDILPLLNERFALLSGGRDNRGGPIICFPATT-KRERIKPEDIKRVVSYFINIP Anopheles_aegypti ------------------------------------------------------------ Culex_quinquefasciatus D-GVRALDILPLLQERFALLSGGRDNRGGPIICFPATT-KRERVKPEDIKRVVSYLIGIP Pediculus_humanus ------------------------------------------------------------ Ixodes_scapularis ------------------------------------------------------------ Caenorhabditis_elegans KMTMKAEDILHVLRDGIAVLPGGRCRAGQAVIVCPS---REQPVNQDNLRNVFLYLFEVT Caenorhabditis_briggsae -MTMKAEDILHVLRDGIAILHGGRCRAGQAVVVCPP---REQLVNQDHLRNVLLYLFEVT Loa_loa DGCPKAEDILHVLRDRVALLPGTRDRNGRAVIIFPARE-NTTPINSDHIRNILIYLHAVT Brugia_malayi DGCPKAEDILHVLRDRVALLPGARDRNGRAVIIFPARE-NTTPINPDHIRNILIYLHAVT Ascaris_suum EGCRKAEDILHVLRDRVAQLPGTRDRKGRPVIVFPARE-SSSPINPDHIRNILLYLHAVT Schistosoma_mansoni GTSLRAVDLIPLLKKKIALLPGGRSRRGGPLLCFPSNS-RADEIPIEDLYVLVRYLTYLP Hydra_magnipapillata PLVYRANDVQDLLGN-LAQITGGYDRKGFLFLTILKNA-CQEEAKIEDVKKVILYLASTR Nematostella_vectensis ---I--------------------DRRGGRIITLPAHTFQGEQQDEESIGQIVSYLANLP Trichoplax_adhaerens DNSLKANDVLKILKEKIAFLSGGRDRSGRAIITFLARV-TFVDIESERLIKLINYLASIP Trio_Human SEEVCKRGFTVIVDMRG--SKWDSIKPLLKILQESF-PCCIHVALIIKPDNFWQKQRTNF Trad_Human SEDVCKRGFTVIIDMRG--SKWDLIKPLLKTLQEAF-PAEIHVALIIKPDNFWQKQKTNF Saccoglossus_kowalevskii ------------------------------------------------------------ Branchiostoma_floridae ------------------------------------------------------------ Strongylocentrotus_purpuratus ------------------------------------------------------------ Harpegnathos_saltator NDEARGLRFTVIVDMRG--TTWDSVKPILKVLHEHF-HRTVHVAFLIKPENFWQKQRTSL Apis_mellifera SDEARGLRFTVIVDMRG--ATWDSVKPILKVLHEHF-HRSIHVAFIIKPENFWQKQRTSL Bombus_terrestris NDEARGLRFTVIVDMRG--ATWDSVKPILKVLHEHF-HRSIHVAFIIKPENFWQKQRTSL Nasonia_vitripennis NDDDRGLRFTIVVDMRG--ATWDSVKPILKVLHDHF-HHSVYVAFLIKPENFWQKQRTSL Tribolium_castaneum NDEARALGFTVLVDMRG--ATWSTVKPILKALHEHFPPGVVHQALIVKPDNFWQKQRTSL Drosophila_melanogaster SDAAKNLGFTVIIDMRGNGNCSTNVKTILKVLQEHF-SANIHNVVIIKPDNFWQKQRASI Drosophila_willistoni SDVAKNLGFTVIIDMRGNGNCSTNVKTILKVLQEHF-SANIHNVVIIKPDNFWQKQRASI Drosophila_grimshawi SDAAKNLGFTVIIDMRGNGNCSTNVKTILKVLQEHF-SANIHNVVIIKPDNFWQKQRASI Anopheles_gambiae SDESKSHGFTIIVDMRGNGNTAASAKMILKVLQENFGTDVIHQAVIIKPDNFWHKQRSSI Anopheles_aegypti -DESKAHGFTIIIDMRGNSNTAASAKMILKVLQENFGSDIIHQAVIIKPDNFWQKQRSSI Culex_quinquefasciatus SDESKSHGFTIVIDMRGNSNTAASAKMILKVLQESFGQDHIHQAVIIKPDNFWQKQRSAI Pediculus_humanus --------------MRG--ATWGTVKPILKVLQEHF-SGYVHVAYIIKPDNFWQKQRTSL Ixodes_scapularis ------------------------------------------------------------ Caenorhabditis_elegans SKMAREKGFLVVIDMRG-KQTWTNVRHILKALSSIE-SSSTVQVFIIKPEKFWEKQKAQM Caenorhabditis_briggsae SKEAREKGFLVVIDMRG-KQTWANVRNILKALSSID-NSTKIQVFIIKPEKFWEKQKAQM Loa_loa ADDYKDRGFTIIIDMRK-GTTWNNVKPILKCIQEHF-PAEVHTVLIIKPDKFWEKHKTSV Brugia_malayi ADDYKDRGFTIIIDMRK-GTTWNNVKPILKCIQEHF-PAEVYAVLIIKPDKFWEKHKTSV Ascaris_suum ADEFKEHGFVIVIDMRK-GTTWNNVKPILKCIQEHF-PAVVHVVLIIKPDNFWEKHKTSV Schistosoma_mansoni DDKVKRLGFVVIIDMRS-GTTWHSVKPILKVLEECL-GQDVTLTFIIKPDKFLEKHKAQL Hydra_magnipapillata SSEEKQKGFSFLVCLKP-TPPFGNVKPITKLLQDGF-PFKIFAVYIIKPEKYKEKILSSS Nematostella_vectensis SEDECRLGFSIILDMRS--CTWSTAKPVLRSLQECF-PEKIHSVYIIKPEGFWERHKTNL Trichoplax_adhaerens CQEVKVKGLTVIVDGRS--VDWRGLKPLLNILEEAF-LDTIAKVFVIKSDSFWKRGKAMI Trio_Human GSSK-FEFETNMVSLEGLTKVVDPSQLTPEF-DGCLEYNHEEWIEIRVAFEDYISNATHM Trad_Human GSSK-FIFETSMVSVEGLTKLVDPSQLTEEF-DGSLDYNHEEWIELRLSLEEFFNSAVHL Saccoglossus_kowalevskii ------------------------------------------------------------ Branchiostoma_floridae ------------------------------------------------------------ Strongylocentrotus_purpuratus ------------------------------------------------------------ Harpegnathos_saltator AKQKKYNFEINTISLEALVKVIDPSQLTADL-DGSLQYDHAQWIDTRLVVEDFTWQAADL Apis_mellifera AKQKKYNFEINTISLEALTKVIDPSQLTADL-DGSLQYDHAQWIDTRLAVEDFTWQASDL Bombus_terrestris AKQKKYNFEINTISLEALTKVIDPSQLTADL-DGSLQYDHAQWIDTRLAVEDFTWQAADL Nasonia_vitripennis AKQKKYNFEINTVSLEALARNIDPSQLTADL-DGSLQYDHAQWIDVRLAVEDFTWQATDL Tribolium_castaneum GSHK-YKFETNMISIEALSKIIDTSQLTADL-DGTLSYDHSTWLEIRLAVEEFAWQAADL Drosophila_melanogaster SSH-KYKFETTTVSIESLNKIVESHQLTGDF-EGQQLYDHQQWTDARLAIEDFFWQAGDM Drosophila_willistoni SSH-KYKFETTTISIEALHKIAESHQLTSDF-EGQQQYDHQQWTEARMAIEDFFWLAGDM Drosophila_grimshawi SSN-KYKFETQTISIEALNKIAESHQLTGDF-DGQQLYDHQQWTDARVAIEDFFWQAGDM Anopheles_gambiae ASN-KYKFETTTISIQSLGKLVEPSQLTSDF-EGFLHYDHAVWIDLRVAFEDFLWQASDI Anopheles_aegypti ASS-KYKFETTTISIQSLNKVVEPSQLTSDF-EGFLHYDHNIWIDLRVAFEDFLWQASDI Culex_quinquefasciatus ASS-KYKFETTTVSINLLSKVVEPSQLTSDF-DGFLHYDHNLWIDLRVAFEDFLWQASDI Pediculus_humanus ASHK-YKFETNVIGLESLPKIIDTSQLTADL-EGTYHYDHTQWIEMRLAVEDFVWQAADL Ixodes_scapularis ------------------------------------------------------------ Caenorhabditis_elegans SLGT-WDFEVEMISFESLIKIIDSSHLPKTV-GGSYPYDHDEWLELRLDLEKWIWNITEI Caenorhabditis_briggsae SLGT-WDFEVEMISFESLIKIIDSSQLPKSISGGNYPYDHDEWLEIRMDLEKWIWNITEI Loa_loa SSGK-YKFDIQMISVEGLTRYVDSSQLTRDL-GGSLLYDHDEWLETRLELERLIWQTIDV Brugia_malayi SSGK-YKFDIQMISVEGLTRYIDSSQLTRDL-GGSLFYDHDEWLETRLELERLIWQTIDV Ascaris_suum SSGK-YKFEVQMISVDGLMRYIEPAQLTRDL-GGTLFYDHDEWLETRLELEKLIWQIIDV Schistosoma_mansoni ASG-KFSFEIQLVSVESLFREVDPSQLTAEM-EGSLPYHHEEWIKIRCCLEEFFLFANDM Hydra_magnipapillata MASSKYRFEINVVSKENVFTFIAPEELTEDL-GGTYIYQHNDWLSMRLAFEKFLFETYAL Nematostella_vectensis KTS-KLSFETTLTSLDGLAKFIEPSQLTASL-GGTLKYDHTDWLNMRLALEKFLYEAMAL Trichoplax_adhaerens TQMK-TELNMQVVSISNLVKQIDITDLTEEL-QGILPYCHEEWIELRLMLEEFSRKSLGV Trio_Human LSRLEELQDILAKKELPQDLEGARNMIEEHSQLKKKVIKAPIEDLDLEGQKLLQRIQSSE Trad_Human LSRLEDLQEMLARKEFPVDVEGSRRLIDEHTQLKKKVLKAPVEELDREGQRLLQCIRCSD Saccoglossus_kowalevskii ------------------------------------------------------------ Branchiostoma_floridae ------------------------------------------------------------ Strongylocentrotus_purpuratus ------------------------------------------------------------ Harpegnathos_saltator LDRLDDLQEDLSRNDFADDVAGAKHGIDLHNEMKKKIMKVPVEDIEVVGQRLLQRFNSNV Apis_mellifera LDRLDDLQEDLSRNDFADDVAGAKHGIDLHNEMKKKIMKVPVEEIEVIGQRLLQRFDNNI Bombus_terrestris LDRLDDLQEDLSRNDFADDVAGAKHGIDLHNEMKKKIMKVPVEEIEVVGQRLLQRFDNSI Nasonia_vitripennis LDRLDDLQEDLSRNDFADDVGGAKHGIDLHNEMKKKIMKVPVEEIGVVGNRLLQRFNINV Tribolium_castaneum LDRLDDLQEDLARNDFADDVSGAKHKIDLHNEMKKKIMKAPVEDIDVLGQRLLQKICGDT Drosophila_melanogaster ADRIDDLQEDLNRNDFAEDVPLARHAIDHHNEMRKKITKLPIEDLDMQGKKLLAKINAMA Drosophila_willistoni ADRIDDLQEDLNRNDFAEDVTQARHAIDHHNEMRKKINKLPIGDLDVQCTKLMPKINMVA Drosophila_grimshawi ADRIDDLQEDLNRNDFAEDVSLARHAIDHHNEMRKKITKLPIEDLDMQANKLLTKINVAS Anopheles_gambiae LDRIDDLQEDLTHSECPEDVNGAKHSIDAHNEMKRKILKLPIEDLDLQGQKLLGKL---- Anopheles_aegypti LDRIDDLQEDLQHSDFPEDVNSAKHSSENHNEMKRKILKLPIEDLDLLGQKLLGKF---- Culex_quinquefasciatus LDRIDDLQEDLQHSDFPEDVNSAKHSSEAHNEMKRKVLKLPIEDLDLQGQKLLGKF---- Pediculus_humanus LDRLDDLQEDLSRKDFADDIQGAKHSIDIHADLKKKIMKAPVEEIDMIGQRLLRRFFFFK Ixodes_scapularis ------MKEDLVSNKFAEDVAGAKRMIEDHLNAKKRVLQIPVDEVDLEGQQVLHRL---- Caenorhabditis_elegans MEKLESVRREICEGEQPVDVTTANAALKKSQHAKNSIFNVPVEGIETEGNKIATRILKPS Caenorhabditis_briggsae METLEAVRRDMCQGEHPIDVKTAEAALKKSQLAKNNIFNIPVDNIEAEGNKIVNRILQPP Loa_loa MHNFENYREEMKNGEMPIDVATAERATAAHVVLKKKILGAPIERIQHDVEQVQQRISGFM Brugia_malayi MHNFENFREEMKNGEMPIDVATAERATAAHVVLKKKILGAPIERIQYDVERVQQRISGCT Ascaris_suum MRSFETYRDEMKNGELPVDVVTAERSTTAHVALKKKLLAAPIEMLQAEAQRIHQRIAGSG Schistosoma_mansoni SDKFGQLYCFLDRKPNPESVDEAKRALEEHRSVRLKIVQAPVPALEAEADRLTSWL---- Hydra_magnipapillata SSKLDDIRRSLLQDDYALTVDGVREQIQHHQYVRKWIEKAPVGLLAEEGNNVIQIIKNSC Nematostella_vectensis LSKLDEIQDGLSKDEFAETQDGLKDQIKKNHHVKKWIVKAPVEILQEEGERILKSIKNPT Trichoplax_adhaerens IHQMDKISDSVGNLNLPKELEAIKERKKDHLKIKQLMHNLPINEFEENGQTILDLIQGER Trio_Human SFPKKNSGSG-------------------------------NADLQNLLPK--------- Trad_Human GFSGRNCIPG-------------------------------SADFQSLVPK--------- Saccoglossus_kowalevskii ------------------------------------------------------------ Branchiostoma_floridae ------------------------------------------------------------ Strongylocentrotus_purpuratus ------------------------------------------------------------ Harpegnathos_saltator TSTGGEGGSIDNGAASCT-----------------------DPDGRALATL--------- Apis_mellifera AASSGEGGSI-ESGATGGT----------------------DPDGRALAAL--------- Bombus_terrestris AASSGEGGSI-ESGATGGT----------------------DPDGRALAAL--------- Nasonia_vitripennis NGSGEGGSIESGATGGS------------------------ESDSRDIANI--------- Tribolium_castaneum GQGGGGGGGGGGGGGSVREPESPNSA---------------NSDTTDIKNL--------- Drosophila_melanogaster PPGGQAPTNSGGPDM-DSGPSSAGQQSQPSQQSRSVGG---NPDMSAAVNK--------- Drosophila_willistoni ATGSATASSNDTASV-DSGTSSAGQQR---------AA---NPDMAAAINK--------- Drosophila_grimshawi GTANCAGGNSGTTDCADSGTSSAGQQQQQQAARLAATGSSNNPDMSAAINK--------- Anopheles_gambiae -----TTYSNRNDDGCHS-APLPTN------------CI--NPDVTSAMNQVREESSGLW Anopheles_aegypti -----TSYSNRNDESCHS-TSSPSK------------CH--NPDISSSLNQVSTKEKSET Culex_quinquefasciatus -----TSYSNRNDESCHS-TSSPSK------------CH--NPDISSALNQ--------- Pediculus_humanus RFSSPIHLGKIVEYLTGYDSGYSGRDSEASTVSL-------NPDLQSAVPQ--------- Ixodes_scapularis --------GMGSSGGGSS-DSGYSGGRES--------GC--GLTQDTAGPQ--------- Caenorhabditis_elegans KGVK-------------------------------------NPDLEATTPY--------- Caenorhabditis_briggsae KGVK-------------------------------------NPDLQATTPY--------- Loa_loa GETPDDSYNSSNGLLTT------------------------NPDLAAALPH--------- Brugia_malayi DGTPDDNYNSSNGLLTT------------------------NPDLTAALPH--------- Ascaris_suum GVTPDDGYNSSSGAAST------------------------NPDLAAALPH--------- Schistosoma_mansoni ------RYGITASQS--------------------------SANASSLVPQ--------- Hydra_magnipapillata KCQNENEM---------------------------------KDEYRDAVTK--------- Nematostella_vectensis SEHLVDGFTI--------------------------------QDYKKAEQQ--------- Trichoplax_adhaerens PIRTS------------------------------------LEDFTASASR--------- Trio_Human -----------VSTMLDRLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEK--MFDWIT Trad_Human -----------ITSLLDKLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEK--MFDWIS Saccoglossus_kowalevskii ------------------------------------------------------------ Branchiostoma_floridae ------------------------------------------------------------ Strongylocentrotus_purpuratus ------------------------------------------------------------ Harpegnathos_saltator -----------VIQHLDSVHAAQQHLLQLWHIKKMKLDQCFQLRLFEQDCEK--MFDWIC Apis_mellifera -----------VIQHLDSVHAAQQHLLQLWHIKKMKLDQCFQLRLFEQDCEK--MFDWIC Bombus_terrestris -----------VIQHLESVHAAQQHLLQLWHIKKMKLDQCFQLRLFEQDCAK--MFDWIC Nasonia_vitripennis -----------VIQHLDSVNAAQQHLLQLWHIKKKKLDQCFQLRMFEQDCEK--MFEWIC Tribolium_castaneum -----------VLQNLEAVHTSQQHLLQLWHQKKLKLDQCFQLRLFEQDCEK--MFDWIC Drosophila_melanogaster -----------ALRQIELIHTGQEKLLMLCQHKKVKLDQCFQWRLFEQDCEK--MFDWIL Drosophila_willistoni -----------ALRQIDLIHTGQESLLMLWQHKKAKLDQCFQWRLFEQDCEK--MFDWIL Drosophila_grimshawi -----------ALRQIDLIHSGQDRLLMLWQHKKVKLDQCFQWRLFEQDCEK--MFDWIL Anopheles_gambiae GDMGRGSGATNVLQQLETTRNAQQQLLNLWQHRKTKLDQCFQLRLFEQDCEK--MFDWIL Anopheles_aegypti AHKFVHLLQLFVLQQLETVRNAQQQLLSMWQHRKTTLDQCFQLRLFEQDCEK--MFDWIL Culex_quinquefasciatus -----------VLQQLETVRNAQQQLLNMWQHKKTTLDQCFQLRLFEQDCEK--MFDWIL Pediculus_humanus -----------ILQNLEAIHASQQHLLQLWHHKKMKLDQCFQLRLI--------MFEWIC Ixodes_scapularis -----------VVRLLESLRVARQHVLQLWHVRKVQLDQALQLRLYQQDAQK-------- Caenorhabditis_elegans -----------ISNLTDSLRLLKGEVAKNWEVRQMELSKVYQQKQFERDAEH--MIETLR Caenorhabditis_briggsae -----------ISNLTDSLRLLKGEVHKSWDTRQAELVKVYYQKRFEEDVEK--MVEALR Loa_loa -----------LASLVNSLRTSKDEIFVQWETRRQKLDHCYQLKLFEQDADKVNMFDWIR Brugia_malayi -----------LASLVNSLRTSKDEIFVQWETRRQKLDHCYQLKLFEQDADK--MFDWIR Ascaris_suum -----------LAALVESLRSSKEDLFIQWETRRQKLDHCYQLKLFEQDAEK--MFEWVR Schistosoma_mansoni -----------VRHTVSQLYEFRTRLQQKWEAGRSRLEQIYQLRLFDEDARG--MSNWID Hydra_magnipapillata -----------VHTVLGELKDKIVLLKDLWINRRTQLEQRFQFNLFKQDAEK--MLSWIN Nematostella_vectensis -----------VQELVESLILKRQRLRELWNIRKQKLDQCFQFRVFQIDAHK--MLKWIK Trichoplax_adhaerens -----------IQTLINIMHTKRQQLRDQWQKQKLNLDQHYQLCLFVKESGK--VREWIK Trio_Human HNKGLFLNSYTEIGTSHPHAMELQTQHNHFAMNCM-NVYVNINRIMSVANRLVESGHYAS Trad_Human HNKELFLQSHTEIGVSYQYALDLQTQHNHFAMNSM-NAYVNINRIMSVASRLSEAGHYAS Saccoglossus_kowalevskii ------------------------------------------------------------ Branchiostoma_floridae ------------------------------------------------------------ Strongylocentrotus_purpuratus ------------------------------------------------------------ Harpegnathos_saltator HNREVFLASYVEIGRSYQLAKNLQEEHKHFTMSSM-NVYVNINKILTMAGRLLETQHYAA Apis_mellifera HNREGFLANYVEIGRSYQLAKNLQEEHKHFTISSM-NVYVNINKILTMASRLLETQHYAA Bombus_terrestris HNREGFLANYVEIGRSYQLAKNLQEEHKHFTMSSM-NVYVNINKILTMASRLLETQHYAA Nasonia_vitripennis HNRENFLANYVEIGRSYQLAKNLQEDHKHFAMNSM-NMYVNINKILTMAGRFLETQHYAA Tribolium_castaneum HNRDVFLLNYVEIGHTYQLAKQLQEEHQHFTMSSM-NVYVNINRILSVASRLIEGGHYAA Drosophila_melanogaster HNRDVFQMSYVEIGHNYSVAKSLQDEHQKFAVASM-NVSVNIDRILAVAARLIESQHYAA Drosophila_willistoni HNRDVFQMSYVEIGHNYSVAKSLQDEHQKFAVASM-NVSVNIDRILAVASRLIESQHYAA Drosophila_grimshawi HNRDVFQMSYVEIGHNYSGAKSLQDEHQKFAVASM-NVNVNIDRILAVAARLIESQHYAA Anopheles_gambiae HNRDVFQETYVEIGHNYAIAKNLQEEHQRFAITSR-NVCVNINRILAVAARLYEGNHYAA Anopheles_aegypti HNRDVFQETYVVIGHNYAMAKKILDDHQRFAVTSR-NVSSNINRILAVAGNLIESNHYAA Culex_quinquefasciatus HNRDVFQETYVEIGHNYALAKNLQEEHQRFAMTSR-NVSFNINRILAVAGKLIESSHYAA Pediculus_humanus HKRDVFLMNYVEIGHSYQPAIELQEEHSHFAMSSM-DVYVNINQILNVGSRLIESNHYAS Ixodes_scapularis ------------------------------------------------------------ Caenorhabditis_elegans PYKKACERSMGDVGGCANDVVRLSAEFEQFQIAVR-GMEVSVKQVFDKENHLRTIGA-RN Caenorhabditis_briggsae PYKKQCERSMGDVGGCVSDVNALAEDFEKFQVAVK-AMEVSVKRVFDQANELRTSGA-RN Loa_loa SHYTLSMQRLLEIGDSEQSTSMLLAEHLDFIAAAN-NTEVNVSHVMTVAKRLREIGNYGK Brugia_malayi SHYALSMQRLLEIGDSEQSTSALLTEHLDFIAAAN-NTEVNVSHVMTVAKRLREIGNYGK Ascaris_suum VHFALLAQRFLEIGDSEQSTSLLIADQREFANNAS-NADINVSHVMSVAKRLLEIGNYGK Schistosoma_mansoni QQRHLFLTEYLDIGQTASHAADLHAEHRQFLSKCS-SVREQVARLTGVAGMLADTGHFAS Hydra_magnipapillata ENRTEFMSNYTEIGDNTEYAKELCEEHKQFEDNCV-DVQANINVILQVANKLHDMQFFDV Nematostella_vectensis ENREDFLINYSEIGNDTESAEELEEEHRNFESSCM-NVYGNIHRVLEIADKLSEAGHYEA Trichoplax_adhaerens RNRDNFLMKLTDIGTSIESAKRHKEDYHRFQESAM-NVYVNVSKLLQQGNKLFPNMQYAK Trio_Human QQIRQIASQLEQEWKAFAAALDERSTLLDMSSIFHQKAEKYMSNVDSWCKACGEVDLP-- Trad_Human QQIKQISTQLDQEWKSFAAALDERSTILAMSAVFHQKAEQFLSGVDAWCKMCSEGGLP-- Saccoglossus_kowalevskii ------------------------------------------------------------ Branchiostoma_floridae ------------------------------------------------------------ Strongylocentrotus_purpuratus ------------------------------------------------------------ Harpegnathos_saltator GHVRAVAGRLDRAWKEFAAGLDERTAVLSLSVVFHHKAEQYVDNVAGWSQACDTSNLP-- Apis_mellifera GHVRAVAGRLDRAWKEFAAGLDERTAVLSLSVVFHHKAEQYVDSVAGWSQACD-AGNLP- Bombus_terrestris GHVRAVAGRLDRAWKEFAAGLDERTAVLSLSVVFHHKAEQYVDSVAGWSQACD-AGNLP- Nasonia_vitripennis GHVRAVAGRLDRAWKEFAAGLDERTAVLGLSVVFHHKAEQYVDSVAGWSQACDATNLP-- Tribolium_castaneum THIRSVASRLDRTWKDFAAGLDERTAVLALSVIFHHKAEQYVDNVPNWKSACENVNIP-- Drosophila_melanogaster QHIKTLAQRLDRTWKDFAAGLDERTAVLQLSVLFHHKAEQYCNSVASWAAACQASQPLP- Drosophila_willistoni QHIKTLAQRLDRTWKNFAAGLDERTAVLQLSVLFHHKAEQYCNSVVSWAAACQASQPLP- Drosophila_grimshawi QHIKTLAQRLDRTWKDFGAGLDERTAVLQLSVLFHHKAEQYCNSVASWAAACQASQPLP- Anopheles_gambiae AHIRTLAARLDKTWKDFVTTLDERTAVLTLSVVFHHKAEQYTESVSSWAAACEATIPTP- Anopheles_aegypti QHIRTLATRLDKTCKDFVTTLDERTAVLSLSVVFHHKAEQYTDSVTSWAAACEATIPTP- Culex_quinquefasciatus QHIRTLATRLDKTWKDFVTTLDERTAVLSLSVVFHHKAEQYTESVSSWAAACEATIPTP- Pediculus_humanus QHIRTVATKLDRVWKEFAAALEKRTSVLQLSVLFHRKAEQYVDNVQTWKQACDNNLNIP- Ixodes_scapularis -------------------GVAEGSALL---------------------ASCQ------- Caenorhabditis_elegans QITDHVAARLAEEWHLVKELMERRSAVLHNAKEFFTSAQRYFAEVPRWTAQPGVNPNDVL Caenorhabditis_briggsae QITDHVTERLTNEWRLVKELMERRATILHNARKFFSSAQCYFAEIPAWTAQPGINPNDVM Loa_loa VQIENVAMHLDDEWRRFKQINEQRSRLLDLTLSFHHKSHIYLSNTPSWLHSITLDNGRRM Brugia_malayi VQIENVAMHLDEEWRRFKQVNEQRSRLLDLALSFHRKSHIYLSNMSSWLHNITLDNGRRM Ascaris_suum VQIESVAMRLEEEWRRFKHALEQRTRLLDQALSFHRKSHLYLSNVPMWMRKVGVEACSSI Schistosoma_mansoni QQILKQANQLEHEWKSFTAALEDRSRVLQLSASFHARAESFLANCPHWESAMRQVNG--- Hydra_magnipapillata ELIERLTNKLDLEWEKLHMAVKRRSIMLAASVSFHMKSEE-------------------- Nematostella_vectensis DRIEALAESVDREWKSFDMEVNQRSSLLSCSVAYHKHSEEFLRNIKYWKQYLEDPDLIKN Trichoplax_adhaerens EDLLEECETLDREWKHFAASLEERGALVRESLLFHKEYENFIRLVDKLKRACHHDRERIP Trio_Human --------SELQDLEDAIHHHQGIYEHITLAYSEVSQDGKSLLDKLQRPLTPGSSDS--- Trad_Human --------SEMQDLELAIHHHQTLYEQVTQAYTEVSQDGKALLDVLQRPLSPGNSES--- Saccoglossus_kowalevskii ------------------------------------------------------------ Branchiostoma_floridae ------------------------------------------------------------ Strongylocentrotus_purpuratus ------------------------------------------------------------ Harpegnathos_saltator --------SEIPVLESHIRQHQTLYEAMCQAYTESQDGHNIDSHSGTS------------ Apis_mellifera --------NEIPILESHIRQHQTLYEAMCQAYTEVYDAYQALLSGLGSMLQVCHGFVSTH Bombus_terrestris --------NEIPILESHIRQHQTLYEAMCQAYTEVYDAYQALLSGLGSMLQVCHGFSSTH Nasonia_vitripennis --------GEIAVLETLIRQHQTLYEAMCQAYTEVYNAYQALLSGLGKMLQVCHSASATI Tribolium_castaneum --------SEIMMLENSIHQHQNLYESMCQAYTEVHSTSKKLLYQLDHLVQVCNQPGSDK Drosophila_melanogaster --------SDIQSLETAIRTHQSLYEAMCQAYTEVHSTSKKLLYQLDHLVQVCNQPPPPG Drosophila_willistoni --------SDIQSLETAIRTHQSLYEAMCQAYTEVHSTSKKLLYQLDHLVQVCNQPPPPG Drosophila_grimshawi --------SDIQSLETAIRTHQSLYEAMCQAYTEVHSTSKKLLYQLDHLVQVCNQSPPPG Anopheles_gambiae --------TNVESLETAIGTHQSLYEAMCQAYTEVHSTSKKLLYQLDHLVQVCNQPPIVN Anopheles_aegypti --------TNVESLETAIRTHQSLYEAMCQAYTEVHSTSKKLLYQLDHLVQVCNQPPAQS Culex_quinquefasciatus --------TNVESLETAIRTHQSLYEAMCQAYTEVHSTSKKLLYQLDHLVQVCNQPPAVN Pediculus_humanus --------NEIIILESYIRQHQSLYESMCQAYTEVHSTSKKLLYQLDHLVQICNQPGNDG Ixodes_scapularis ------------------------------------------------------------ Caenorhabditis_elegans --------FNQESLEEAIRKHDAFWAQVEEVYAQAYDDASKVTRALKEA----------- Caenorhabditis_briggsae --------FSQESLEIAIRTHDGFWAQVEEVYAQAYEDALNLMKSLKES----------- Loa_loa GQ------YSGDELEAAIAEHERFGEMFLQTYAEAVGDGRSLTQILKTL----------- Brugia_malayi GQ------YSGDELEAAIAEHERFGEMILQTYAEAVGDGRSLTQILKTL----------- Ascaris_suum GQ------CTGDELEAAIAEHEHFGETFLQTYAEAVGEGRSLTQLLKAL----------- Schistosoma_mansoni --------TSVHELNQALITLQEYWKEAQSAHEEVCTDGRALANHLSSPVPTGSHTS--- Hydra_magnipapillata ------------------------------------------------------------ Nematostella_vectensis --------SNVSTVEIKIQELDKLRQEFEDSFHTVSTDSKALLGELQKPAVAFDDQ---- Trichoplax_adhaerens --------QGLSTLQDLQLKHNTIQEEFKEAYNKIKRIGKDLSQLLHTPSTIVINSNMW- Trio_Human ----------------------------------------------------------LT Trad_Human ----------------------------------------------------------LT Saccoglossus_kowalevskii ------------------------------------------------------------ Branchiostoma_floridae ------------------------------------------------------------ Strongylocentrotus_purpuratus ------------------------------------------------------------ Harpegnathos_saltator ----------------------------------------------------------GN Apis_mellifera SSSSDT-FCIDYVHSTSKKLLYQLDHLVQVCNQPQGIDHTARKHSQDGHGIDGHSGMSGN Bombus_terrestris GSSSDTSFCIDYVHSTSKKLLYQLDHLVQVCNQPQGIDHTARKHSQDGHGIDGHSGMSGN Nasonia_vitripennis GSDEYSQDGH----------------------------------------MDGRGGMSGN Tribolium_castaneum KHGDGSNYENRSG---------------------------------------------GN Drosophila_melanogaster VPD-------------------------------------HRKNSNNGS-FNKYER--QN Drosophila_willistoni VPD-------------------------------------HRKNSAN---FNKYER--QN Drosophila_grimshawi VPD-------------------YRKNNSNNSNSSSGSNSNSNSNYNKYER--------QN Anopheles_gambiae ------------------------------------------TRKNDNSHFNG-----GN Anopheles_aegypti STI-----------------------------------LQRFSSLQNNNHFNG-----GN Culex_quinquefasciatus ------------------------------------------TRKNDNSHFNG-----GN Pediculus_humanus NRKHVDTIDGVVGRQN------------------------------------------GN Ixodes_scapularis ------------------------------------------------------------ Caenorhabditis_elegans ------------------------------------------------------------ Caenorhabditis_briggsae ------------------------------------------------------------ Loa_loa ----------------------------------------------------------AN Brugia_malayi ----------------------------------------------------------AS Ascaris_suum ----------------------------------------------------------GG Schistosoma_mansoni ----------------------------------------------------------LT Hydra_magnipapillata ------------------------------------------------------------ Nematostella_vectensis ----------------------------------------------------------FL Trichoplax_adhaerens ----------------------------------------------------------TA Trio_Human ASANYSKAVHHVLDVIHEVLHHQRQLENIWQHRK----VRLHQRLQLCVFQQDVQQVLDW Trad_Human ATANYSKAVHQVLDVVHEVLHHQRRLESIWQHRK----VRLHQRLQLCVFQQDVQQVLDW Saccoglossus_kowalevskii ------------------------------------------------------------ Branchiostoma_floridae ------------------------------------------------------------ Strongylocentrotus_purpuratus ------------------------------------------------------------ Harpegnathos_saltator PAADYSEGASHVLAVIHQILGHHRALEARWHARK----VKLHQRLALRLFQEDVKQVLDW Apis_mellifera PAADYSEGASHVLAVIHQILGHHRALEARWHARK----VKLHQRLALRLFQEDVKQVLDW Bombus_terrestris PAADYSEGASHVLAVIHQILGHHRALEARWHARK----VKLHQRLALRLFQEDVKQVLDW Nasonia_vitripennis PAADYSEGASHVLAVIHQILGHHRALEARWHARK----IKLHQRLALRLFQEDVKQVLDW Tribolium_castaneum PAADYSEGASHVLAVIHQILNHHRALEQKWHAKK----IKLHQRLALRLFQEDVKQVLDW Drosophila_melanogaster PAADYSEGASHVLAVIHQILSHHRTLEAKWHQER----LRLHQTLALRLFQEDVKQVLDW Drosophila_willistoni PAADYSEGASHVLAVIHQILGHHRTLEAKWHQEK----IRLHQTLALRLFQEDVKQVLDW Drosophila_grimshawi PAADYSEGASHVLVVIHQILGHHRKLEAKWHQEK----IRLHQTLALRLFQEDVKQVLDW Anopheles_gambiae PAADYSEGASHVLAVIHQILGHHRALESKWHAGK----LRLHQKLALRLFQEDVKQVLDW Anopheles_aegypti PAADYSEGASHVLAVIHQILGHHRALESKWHAGK----LRLHQKLALRLFQEDVKQVLDW Culex_quinquefasciatus PAADYSEGASHVLAVIHQILGHHRALESKWHAGK----LRLHQKLALRLFQEDVKQVLDW Pediculus_humanus PAADYSEGASHVLAVIHQILNHHRTLETKWQAKK----IKLHQRLALRLFQEDVKQVLDW Ixodes_scapularis -AGDYSEGAKHVLSVIHEILGQHRTLETKWHKKK----LKLHQRLALRLFQEDVRQVLDW Caenorhabditis_elegans -----DAEDNVAREHSSRLQRAHKQLMEKWKERQ----VLLHHMLAMIAFETDVRLVVDW Caenorhabditis_briggsae -----ETEDNVAKEHSSRLQRAHKQLGEKWKERQASCLVLLHHMLAMIAFETDVKLVVDW Loa_loa DAVGQNNAYKHVVDLIQQITRAHKELYSQWQAKK----LRLHSRLALIAFETDTHRVLQW Brugia_malayi DAVGQNNAYKHVVDLIQQITRAHKELHSQWQAKK----LRLHSRLALIAFETDTHRVLQW Ascaris_suum DVIGQNNSYKHVVDVIQQITRAHKEMHAQWQERK----IRLHSRLALIAFETDTQRVLQW Schistosoma_mansoni AAVDYSQGRKHCTDLVHEIWAWFKQLERVFGERR----RRLTARLALLMFKEDVGQVLAW Hydra_magnipapillata --------------------------------------------------------ILKY Nematostella_vectensis KSPEYSEASSHVMDIYLEVHEHHRQLGILWEKQR----TRLKDHLHLCMFDQDSKQVIRW Trichoplax_adhaerens ASPTYNEAANHVLSLLHTVEIEKEEFERKWSSVV----KKLDQKYQLCIIDEDSDRVIEW Trio_Human IENHGEAFLSKHTGVGKSLHRARALQKRHEDFEEVAQNTYTNADKLLEAAEQLAQTGE-- Trad_Human IENHGEAFLSKHTGVGKSLHRARALQKRHDDFEEVAQNTYTNADKLLEAAEQLAQTGE-- Saccoglossus_kowalevskii ------------------------------------------------------------ Branchiostoma_floridae ------------------------------------------------------------ Strongylocentrotus_purpuratus ------------------------------MTNDSTTNTFTNAERLLKDAAQLAQTGE-- Harpegnathos_saltator LTNHGEVFIRKNTGVGRNLQKARVYQKSHEHFENVAQNTYTNATKLLTAAEELAHTGE-- Apis_mellifera LTNHGEVFIRKNTGVGRNLQKARVYQKSHEHFENVAQNTYTNATKLLTAAQELAHTGE-- Bombus_terrestris LTNHGEVFIRKNTGVGRNLQKARVYQKSHEHFENVAQNTYTNATKLLTAAQELAHTGE-- Nasonia_vitripennis LTNHGEVFIRKNTGVGRNLQKARVYQKSHEHFENVAQNTYTNASKLLTAAEELAHTGE-- Tribolium_castaneum LSNHGEVFIRKNTGIGRNLQKARVYQKSHEHFENVAQNTYTNADKLLAAAEELAHTGE-- Drosophila_melanogaster LKNHGEVFLRKNTGIGRNFHKARVYQTSHDNFENVAQNTYSNAQKLLAAADELARSGE-- Drosophila_willistoni LKNHGEVFLRKNTGIGRNLHKAQVYQNSHEHFENVAQNTYSNAEKLLSAAEELARSGE-- Drosophila_grimshawi LKNHGEVFLRKNTGIGRNLQKARVYQKSHEHFENVAQNTYSNAEKLLSAAEELARSGE-- Anopheles_gambiae LQNHGDVFLRKNRGIGKSLQKARIYQTSHEHFENVAQNTYRNAEKLLAAAEELARSGE-- Anopheles_aegypti LQNHGDVFLRKNRGIGKSLQKARIYQTSHEHFENVAQNTYRNAEKLLAAAEELARSGE-- Culex_quinquefasciatus LQNHGDVFLRKNRGIGRSLQKAQIYQTSHEHFENVAQNTYRNAEKLLAAAEELARSGE-- Pediculus_humanus LTNHGEAFLEKNVAIGRNLQKARVYQKSHEHFENVAQNTYTNAEKLLTAAEELAQTRE-- Ixodes_scapularis LEKHGEVFLRKNPGIGRNLVRARVLQKSHEHFENVAQNTYTNAEKLLAAAEELAQTGE-- Caenorhabditis_elegans LEQHGEPYLRRNIHIGENVNQARSFQRNHTNFQRVAANTYGNVQKLHQVYQDVTKSGSKI Caenorhabditis_briggsae LQLHGEPYLRRNIHIGENVNQARTFQRNHSNFQRVAANTYGNVQKLRRVYQDVSNSGSQV Loa_loa LEEHGDAYLNKNTAIGNNLSQAKMLQRNHSHFRSVASNTYSNAEKLFTASNTIIESGE-- Brugia_malayi LEEHGDAYLNKNTAIGE------------------------------------------- Ascaris_suum LEQHGDAYLNKNTAIGVNLAQAKVLQRNHTHFRSVASNTYSNAEKLFTASNTIIESGE-- Schistosoma_mansoni LTEHGEPFLQRQTSVGKSIQRAEQLYSAHMQFEQVAANTLTNAEKLISAADELAAQAD-- Hydra_magnipapillata LKGNGNNFLSKYSWVGDGLEIAEELLADQDEFEK-SFQTYLKAKKLLETAVHLAEKKE-- Nematostella_vectensis IEEHGETFLKKHTGIGKSLVKAEALLKRHEEFEKIAQNTYTNAAKLLEAARHLAQSGE-- Trichoplax_adhaerens IELHGEMYLIKNFRIAKSLSKADMLLRKHEEFEKMCETMYNNAEKLLKTCEHLTETAE-- Trio_Human CDPEEIYQAAHQLEDRIQDFVRRVEQRKILLDMSVSFHTHVKELWTWLEELQKELLDDV- Trad_Human CDPEEIYKAARHLEVRIQDFVRRVEQRKLLLDMSVSFHTHTKELWTWMEDLQKEMLEDV- Saccoglossus_kowalevskii ------------------------------------------------------------ Branchiostoma_floridae ------------------------------------------------------------ Strongylocentrotus_purpuratus CEPDEIEPVARALEAKVGDFISRVAQRRQLLVMSVAFHQHSKELSIWYKELQESLRSSI- Harpegnathos_saltator CAPDEIYAVAQELEAHVSSFAARVEQRRRRLDLAVVFYTHEKELTGWVDELRQELQQDE- Apis_mellifera CAADEIYAVAQELEAHVSSFAARVEQRRRRLDLAVVFYTHEKELSGWVDELRQELQQDE- Bombus_terrestris CAADEIYAVAQELEAHVSSFAARVEQRRRRLDLAVVFYTHEKELTGWVDELRQELQQDE- Nasonia_vitripennis CAPDEIYAVAQELEAHVSSFAARVEQRRRRLDLAVVFYTHEKELSGWVDELRQELQQDE- Tribolium_castaneum CDPDEIYSVAHELEAHVTSFATRVEQRRRRLDLAVLFYTHEKELSNWVDDLRQELQSDE- Drosophila_melanogaster ADPNEIYSVARELELQVGSFAERVEQRRRRLDMAVIFYTHEKDVTAWIDKLRTDVSTDET Drosophila_willistoni ADPNEIYSVARELELQVASFAERVEQRRRRLEMAVIFYTHEKEESAWIDQLRTDVSTDET Drosophila_grimshawi ADPNEIYSVARELELQVASFAERVEQRRRRLEMAVIFYTHEKEVSAWIESLRTDVSTDET Anopheles_gambiae VSPQEIFSVAQELETNVASFAERVEKRRRRLDLAVVFYSNEKEISAWQEQLHAEVTNEES Anopheles_aegypti VAPQEIFSVVRELETNVASFAERVEQRRRRLDLAVLFYTNEKEIAVWSEQLHTEMANEES Culex_quinquefasciatus VAPQEIFSVVRELETNVASFAERVEQRRRRLDLAVLFYTHEKEISAWLEQLHTEMANEES Pediculus_humanus CNAEEIYSVAHELENHVTSFANRVEQRRRRLDYAVRFYSHDKELSNWVDQLRQEIQNVE- Ixodes_scapularis CNADDICGVAQDLEDQITSFATRVEQRRQLLQLAVIFFTHDKEL---------------- Caenorhabditis_elegans CDVDTMHGLMTDLSAKIEKFTKIENSRELLLRQSVLFHTHYKELTDWYGKMGEKYKDR-- Caenorhabditis_briggsae CDVNKMQELMTDLTAKIEKFTTIEQSREHLLRQSVLFHTHYTELTDWYTKMREKYNEK-- Loa_loa CDVQQMTVVVEELRRRIEAFSVRVEARRDLLNKSVLFHTHYSEIMEWYGRMEVKSSQYD- Brugia_malayi CDVQQMSIVVEELRRRIEAFSVRVEARRDLLNKSVLFHTHYSEIMEWYGRMEVKSSQYD- Ascaris_suum CDVKQMNAVVDELRRRIESFSARVEARRDLLNKSVLFHTHYNEITEWYTRMDAKSAQYE- Schistosoma_mansoni -DPEEILQDASELQHRISAFTRAVEVRRETLDLGCGFYSHTKEALAWLHNARETHNPGE- Hydra_magnipapillata CDPQEIKQKALQIETEVKLFTSKIKKRRELLKMAVSFYKNAQKLTKMTEKLKEDMNLDA- Nematostella_vectensis CNPEEIQKRVDYFEKRVQEFIGRVNRRKGLLKLAVNFYTRTQKLTELVEQLKSQLELEE- Trichoplax_adhaerens CDKRAVQNLRKRLFDTVENFRKCVCKRREMIELSIVFHSHTKEFTKWLNGVKMKLCQDA- Trio_Human ---YAESVEAVQDLIKRF-GQQQQTTLQVTVNVIKEGEDLIQQL-------------RDS Trad_Human ---CADSVDAVQELIKQF-QQQQTATLDATLNVIKEGEDLIQQLRSAPPSLGEPSEARDS Saccoglossus_kowalevskii ------------------------------------------------------------ Branchiostoma_floridae ------------------------------------------------------------ Strongylocentrotus_purpuratus ---VSEAVDGAEKDLAEF-EHQRTITVDASVNTIGIGQNLIDQL-------------RQI Harpegnathos_saltator ---VAENLETAERLLEQC-AQHRSSCLDACASTIAQGEALLQEL--------------RE Apis_mellifera ---VAENLETAERLLEQC-AQHRASCMEACASTIVQGEALLREL--------------RE Bombus_terrestris ---VAENLETAERLLEQC-AQHRASCMEACASTIVQGEALLREL--------------RE Nasonia_vitripennis ---VAENLETAERLLEQC-AQHRTSCLEACASTIVQGEALLQEL--------------RD Tribolium_castaneum --SIAESLEATERLLEQT-AQHRDQSLDACASTIAQGEALLQEL--------------RS Drosophila_melanogaster -RLSQENLEGIERILRQYQRDQQESSVNVCLTTISQGEALLQEM--------------RS Drosophila_willistoni -RLSQENLEGIERLLQQY-RNQQESTVNRCMTTIAQGEALLQEM--------------RS Drosophila_grimshawi -RLSQENLEGIERLLQQY-RDQQESTVNMCIAIIAQGEALLQEM--------------RS Anopheles_gambiae LELANEHLEGTERMLEQC-KEQEENTLKTCMQAIAQGEALLQEL--------------RA Anopheles_aegypti MELANETLEGTERLLEQC-KEQEENTLKTCIQAIAQGEALLQEL--------------RT Culex_quinquefasciatus MDLANEHLDGTERMLEQC-KEQEENTLKTCIQAIAQGEALLQEL--------------RA Pediculus_humanus ---APESLEAAEQLLEQC-SQQKESSLDACNRTIGEGQALLQEL--------------RS Ixodes_scapularis ------------------------------------------------------------ Caenorhabditis_elegans --RIDLTVPTCDKNKERF-VLETDETAQAYAMTIDEGKTLIEMM--------------QR Caenorhabditis_briggsae --RIELTVPVCDKNKERF-VLETDETAQAYAMTIDEGKMLIEMM--------------HN Loa_loa --IISTNVQEGERRKEEW-MIESDATAQAYATTMGEGNQLIRAL--------------EQ Brugia_malayi --FVSTNVQEGERRKEEW-MIESDATAQAYATTIGEGNQLIKAL--------------EQ Ascaris_suum --RVSTCVQEGEQRKEEW-MIESDATAQAYATTMSEGHQLVKAL--------------EQ Schistosoma_mansoni --HLPASIEGMEDELTSF-HRNRATMEKDVDRALAEGEALIARL---------------- Hydra_magnipapillata ---TSAEPQNFDEMLEKH-RHECEATLEKLLSTVQEGENLSAEL--LQESKVTDKDTRTS Nematostella_vectensis ---VSDNPDNIATVLTNL-KHQGEATLDSIHTAIDEGETIVEEL--------------KL Trichoplax_adhaerens ---FASSLAEAKEMLEGC-QVRQKAALNAQRLTKGDCDNLIRSL----KDHYESFAALKN Trio_Human AISSNKTPHNSSINHIETVLQQLDEAQSQMEELFQERKIKLELFLQLRIFERDAIDIISD Trad_Human AVSNNKTPHSSSISHIESVLQQLDDAQVQMEELFHERKIKLDIFLQLRIFEQYTIEVTAE Saccoglossus_kowalevskii ------------------------------------------------------------ Branchiostoma_floridae ------------------------------------------------------------ Strongylocentrotus_purpuratus EMDTKKANYSDTCHHIDGMLNNLEDGRSKLDDLWATRRLKLELCLQLRHFERDALELLSQ Harpegnathos_saltator AT--DAPDTTGSISAIETALDRLAGLRQELEDLWATRKLRLELCLRLRVFERDALEASGQ Apis_mellifera ST--DAPDTTGSISAVEAALDRLASLRQELEDLWATRKLRLELCLRLRVFERDALEASGQ Bombus_terrestris ST--DAPDTTGSISAVEAALDRLAGLRQELEDLWATRKLRLELCLRLRVFERDALEASGQ Nasonia_vitripennis ST--EMPDTTGSIAAVEAALDRLAGLRQELEDLWATRKLRLELCLRLRVFERDALEASGQ Tribolium_castaneum I---GEMDSTGSISAVESALDRLAKQRSDLEELWAARKLRLDLCLRLRLFERDALEVSSQ Drosophila_melanogaster L---EYADNTGSIAALEATLEKLNKQKVELEELWSARKFRADLILRLRYFERDARLLSVQ Drosophila_willistoni L---EYTDNTGSLAALEATLEKLSKQKIELEELWSARKFRADLILRLRYFERDAMELSSQ Drosophila_grimshawi L---EYVDNTGSLAALEATLAKLNKQKIEVEELWSARKFRADLILRLRYFERDAMELSSQ Anopheles_gambiae I---EEEDSSGSLTAVQNALDRIQKNRLDLEGLWQTRRMKIDLYLRLRIFERDALEVSSQ Anopheles_aegypti I---EEEDSSGSLTAVQNALERIQKNRLELENLWQARKMKFDMYLRLRIFERDALEVSSQ Culex_quinquefasciatus I---EEEDSSGSLTAVQNALERIQKNRLDLENLWQQRKMKIDMYLRLRMFERDALEVCSQ Pediculus_humanus IGLTSEMDTTGSVTAVESALDRINKQREELEELWATRKLKLDLCLRLRLFERDALEVSSQ Ixodes_scapularis ---------------------------------------------------------SSQ Caenorhabditis_elegans ATRVFDVDYSASVAHIQLLISDIEDKNTQISSEWSPRRTLLHIASKFAMFEQNQFEVLEQ Caenorhabditis_briggsae ATRIFDVDYTVSIAHIQTLISDIENKNTQISSEWGPRRTLLHIASKFAMFEQNKYEVLEQ Loa_loa QAKMMNIDNRETAAVIERLINDIEQRHAKLADRWPHQRRSLQLGVKFAVFIKDCKQIIQQ Brugia_malayi QAKMMNIDNHDVVAVIERLINDIEQRHAKLADRWPHQRRSLQLGVKFAVFVKDCKQIIQQ Ascaris_suum QAQMMHVDNRETVNAIERLIGDIEQRHSKLVDRWPRQRSALQLAVKFAVFLQDCSQITLQ Schistosoma_mansoni -------KDSEEIAHLRTVLNQVSNERTTVSTLLTERQVRLDLCLQLRLFEADVHSALDC Hydra_magnipapillata WFSTGLNSPEQSRLAVELYLKELNLNRMQLQKLWKGRQQKLDYWVKVKHYERDTNLLYLD Nematostella_vectensis AS--ADGMDSSSLHHVEKVIKELDRVRRAIEHSWSRRRQQLELWLQLREFERAAKQLKDR Trichoplax_adhaerens KNKPSEELLNEAVDLVEEVIAGLSEKRRAVDGLWAMRLSKLELCLDFFELKENIDKFMQD Trio_Human LESWNDELSQQMNDFDTEDLTIAEQRLQHHADKALTMNNLTFDVIHQGQDLLQYV---NE Trad_Human LDAWNEDLLRQMNDFNTEDLTLAEQRLQRHTERKLAMNNMTFEVIQQGQDLHQYI---TE Saccoglossus_kowalevskii ------------------------------------------------------------ Branchiostoma_floridae ------------------------------------------------------------ Strongylocentrotus_purpuratus LPIWTQEMHNRDY---SFDLDAADFILKSHLELVESIQENTVQLIQKGRDLVQLFDSAGK Harpegnathos_saltator LEMWAQELQ------GPPREGSPEQLLRVHNDGVAHMQNTAFQVLHRGQELAQVLEEAGV Apis_mellifera LEMWAQELQGPS------REGSPEQLLRAHNDGVAHMQNTAFQVLQQGQELAQVLEQAGV Bombus_terrestris LEMWAQELQGPP------REGSPEQLLRVHNDGVAHMQNTAFQVLQQGQELAQVLEQAGV Nasonia_vitripennis LEMWAQEMQ------NPPREGSPEQLLRAHNDGVVHMQNTAFQVLQQGQELAQVLDQSGV Tribolium_castaneum LEMWSEELQHSEL---TRDIAKAEQFLRLHNESVSQMQNTTYQVLQQGQDLIQVFENSGI Drosophila_melanogaster MEMWSEELQHADL---SRDYQKAEQLIRMHNESVTEIQNATYEVVQQGQDLLQLFENAGF Drosophila_willistoni LEIWSEELQHEVL---SRDYQKAESLIRLHNESVTDIQNATYEVLQQGQDILQLFENAGF Drosophila_grimshawi LEIWSEELQHADL---SRDYQKAEQLIRMHNESVTDIQNATYEILQQGQDLLQLFENAGF Anopheles_gambiae LEMWSEELQHTEV---SRDFQKTEQFLRLHNESVNQMQTTTYQVMNQGHELMQLFESSGL Anopheles_aegypti LEMWAEELQHTDV---SRDFQKTEQVLRLHNESVSQMQTTTYQMINTGQELMQLFESSGV Culex_quinquefasciatus LEMWAEELQHTDV---SRDFQKTEQVLRLHNESVSQMQTTTYQMINTGQELMQLFESSGV Pediculus_humanus LELWAEKLQHTEL---SRNAQKAEHLLRLHNESVAHMQDTTFQVLQTGQELAQVF----- Ixodes_scapularis LELWMKELRHTEV---TRELAQAERLLQLHTDSVAHMQQAVFQLLQRGQELSQVLESSGV Caenorhabditis_elegans IKSWEVDMR--EMAESDSFYDKADSVLPFHKDNQQQVRNAIADIQKSAKELSQAL----- Caenorhabditis_briggsae IKGWEEDMR--EMVESPSFHDKADNVMPYHIENQEKVREAISSIQKAAMELSQVL----- Loa_loa LKNWREDMV--ALVKSNNFAERAEHILPYQDDNTTQVKNAVTGVKNNAAELLQAL----- Brugia_malayi LKNWREDMV--ALVKSNNFAERAEHILPYQDDNTTQVKNAVTGIKNNAAELLQAL----- Ascaris_suum MKNWQDDMV--ALVNSESFDTRAQHILPYQEDNEAQVKNAVLEINNSAAELVQAV----- Schistosoma_mansoni LRHNIPSLS---------NLNQSNDVNSIHQNNNTTTNRYFWLADPRQAPDMNAI-EEVD Hydra_magnipapillata VKKWNSSWQ---KKELSSDFKKASSMFERFENEFKAFINRFHVLVSEGKELEKEL----- Nematostella_vectensis LESCEELLERGVV---APDLPRAKQALTHHEDYVQDIENASLRTFCRGEELIDALKQSEI Trichoplax_adhaerens CDQQRSEIL---DATYPDSSQQMEMLINAYEDKNTLFTSQLEELQLLRDNIVPQI----- Trio_Human VQASGVELLCDRDVDMATRVQDLLEFLHEKQQE---LDLAAEQHRKHLEQCVQLRHLQAE Trad_Human VQASGIELICEKDIDLAAQVQELLEFLHEKQHE---LELNAEQTHKRLEQCLQLRHLQAE Saccoglossus_kowalevskii ------------------------------------------------------------ Branchiostoma_floridae ------------------------------------------------------------ Strongylocentrotus_purpuratus VSMRTGSIP------AQTRITVLLDDIRDAYLE---LEDVSESRRIQLEQCRDLRQFEVD Harpegnathos_saltator CIMADGQHS------ATARVQVLLEFLNERELD---AEDLAEMRRVRLEQASQLVQLQTD Apis_mellifera CIMADGQHS------AATRVQVLLEFLNEREMD---AEDLAEMRRVRLEQASQLVQLQTD Bombus_terrestris CIMADGQHS------AASRVQVLLEFLNEREMD---AEDLAEMRRVRLEQASQLVQLQTD Nasonia_vitripennis CIMADGQHT------AANRVQVLLEFLNEREMD---AEEMAENRRVILEQTAQLVQLQQD Tribolium_castaneum CVMADAQYN------AQTRVQVLLEFLHDREVD---LEDLAEVKRVKLEQCIQLGQFQND Drosophila_melanogaster ISMADATHT------AQARIEYLLDFLREREID---LEEMSEAKRAKLEQAVQLCQFQND Drosophila_willistoni ISMADATHT------AQARIEYLLDFLREREID---LEELSEAKRAKLEQAVQLCQFQND Drosophila_grimshawi ISMADATHT------AQARIEYLLDFLREREID---LEELSEAKRAKLEQAVQLCQFQND Anopheles_gambiae LIMADANHT------AQTRVQCLLEFLHDRELD---LEDMAEAKRIKLEQSMQLCHFQND Anopheles_aegypti LIMADPHTN------AQTRVQYLLEFLHDRELD---LEDLAEAKRIKLEQSMQLCHFQND Culex_quinquefasciatus LIMADPHTT------AQTRVQYLLEFLHDRELD---LEDMAESKRIKLEQSMQLCHFQND Pediculus_humanus -ETSKISLMADSQYSAQTRVQVLLEFLHEREMD---LEDIAEIKRVKLEQCVQLCQFQND Ixodes_scapularis QVMADGQYN------AQSRIQALLEFLHEREMD---IEDLAEVKRVRLEQCIQLCQLEKD Caenorhabditis_elegans ---YSQKLTDLRDKRDRVVLEAIREHVRELEIAESRVMTYANETSMRMQAASEVGDLRRI Caenorhabditis_briggsae ---YSHKLTDLRDKRDRIVLEAIRDHIRELEIDESRVMAYANETSSRINAVREVVELRKV Loa_loa ----RDNESTLVNTEGILATDVIITSLQQLTDCQREVMQVAQETHHRIEQCMQFNRARAM Brugia_malayi ----RDNESTLVNTEGILATDVIITSLQQLTDCQREVMQVAQETHHRIEQCMQFNRARAM Ascaris_suum ----AGSELNLVCADGVPVRKVISDSVEQLSACEREVMEVANRTRWRIGQCMALNRARAM Schistosoma_mansoni SGMGDSAET------AVERVHRLMTELADVVTS-------VDVLNERLNGELDWRRLQLQ Hydra_magnipapillata ASCGVVVTIAVSDTGKVDSVKYVSEVLRKLVLEFDFIKKINTSLRVKYEFTLKQRKLEAD Nematostella_vectensis ELRVKDPLT-AENIDAQTHVHNLLEVLHRKRRD---LRDLAEERKIKLEQNLLLRQLESD Trichoplax_adhaerens -QDLQINIPSSSDENEQDHVSALNASMQLCVDKQQQFVNTNSTKLAFMKRHLTLVKFIEK Trio_Human VKQVLGWIRNGESMLNAGLITASSLQEAEQLQREHEQFQHAIE---------KTHQSALQ Trad_Human VKQVLGWIRNGESMLNASLVNASSLSEAEQLQREHEQFQLAIESLFHATSLQKTHQSALQ Saccoglossus_kowalevskii ------------------------------------------------------------ Branchiostoma_floridae ----------------------------------------------------KTHLSALT Strongylocentrotus_purpuratus AEQVETWIHTAEKMLAVA-AIPNSLNEAEQLQAEHQQFELAIE---------KTQESAIR Harpegnathos_saltator ASHVAKWIRNGESMLLASLRVPENLQDAEQLRLEHDQFQVAIE---------KTHTSAVQ Apis_mellifera ATHVANWIRNGEAMLLASLRVPENLQDAEQLRLEHEQFQVAIE---------KTHTSAVQ Bombus_terrestris ATHVANWIRNGEAMLLASLRVPENLQDAEQLRLEHEQFQVAIE---------KTHTSAVQ Nasonia_vitripennis AGHVANWIRNGEAMLLTTLRIPENLQDAEQLRHEHEQFQVAIE---------KTHTSAVQ Tribolium_castaneum ANQVISWIRNGESMLMASFTIPNSLADAELLKKEHEQFQVAIE---------KTHTSAVQ Drosophila_melanogaster ANQVISWIRNGEAMLVASFVTPNSLQEAEQLRKGHEQFQIAIE---------KTHTSAVQ Drosophila_willistoni ANQVISWIRNGEAMLVASFVTPTSLQEAEQLRKGHEQFQIAIE---------KTHTSAVQ Drosophila_grimshawi ANQVISWIRNGEAMLVATFVTPNSVQEAEQLRKEHEQFQIAIE---------KTHTSAVQ Anopheles_gambiae ANQVISWIRNGEAMLMANFSIPNNFQEAEQLRKEHEQFQVAIE---------RTHTSAVQ Anopheles_aegypti ANQVISWIRNGEAMLMANFSIPNSYQEAEQLRKEHEQFQVAIE---------RTHTSAVQ Culex_quinquefasciatus ANQVISWIRNGEAMLMANFSIPNSYQEAEQLRKEHEQFQVAIE---------RTHTSAVQ Pediculus_humanus ANQVVKWIRNGESMLTASFTIPNSLQDSEQLKKDHEKFQVAIE---------KTHTSAVQ Ixodes_scapularis ANQVNTWIRNGEAMLSATFVIPTCLPEAEQLRSQHEQFQLAIE---------KTHASAIQ Caenorhabditis_elegans SNSVCKLIDNQLSALTQLGVIPNDYNDTVQKQEELRAFRDAVQ------HKLKEPYDAFV Caenorhabditis_briggsae SLGVCRLIETQLQALTKLGVIPHDYNDTVQKQEELRAFRDAVT------IRLRDPYDAFV Loa_loa AAVAIQKMQYEETKLLHMNTIPTSLEEALAAQAAHKQFQHAVE---------SISRTTSA Brugia_malayi AAVAIQKMQYEETKLLHMNTIPISLEEALAAQAAHKQFQHAIE---------SISRTTSA Ascaris_suum ASQVIVTIQKEEQKLLQMNVIPYNYEEALAAQVAHKHFQQTIE---------NTNHIAMA Schistosoma_mansoni SRQVLHWIGQCESILHQTAVIPSSLTEAETLYADHEKFQPVLN---------DAHPQAVQ Hydra_magnipapillata AKKVSGWIRHGESILEASLEAGHSLYEAEALLREYERFHVAIE-------VITTRLGVLD Nematostella_vectensis AKQVVGWVRNGEAMLYACTDLGSSLVEAEALLREHDEFQRAIE---------KTCQSATE Trichoplax_adhaerens GNELSGWIRHAELSLINFSEIGRNPIEAKSLQEQFEGFKKTID---------CIGQSVEN Trio_Human VQQKAEAMLQANHYDMDM-IRDCAEKVASHWQQLMLKMEDRLKLVNASVAFYKTS-EQVC Trad_Human VQQKAEVLLQAGHYDADA-IRECAEKVALHWQQLMLKMEDRLKLVNASVAFYKTS-EQVC Saccoglossus_kowalevskii ------------------------------------------------------------ Branchiostoma_floridae VQQKAENLIGNNHYEPEA-IRACAENVALHWQQLMQKAEDRQRLINAAVQFYKTA-EQVC Strongylocentrotus_purpuratus LHDTAYKLLESRHYDSER-IQGIASSIERRWQALVMQSEDRRKLFQYAASFYKTS-EQVQ Harpegnathos_saltator VKHRADALVSANHYDPKS-IRDVAEDVTKRWQQLVTCAEERHKLVTASINFYKTA-EQVR Apis_mellifera VKHRADALVSANHYDPKS-IREVAEDVTKRWQQLVTCAEERHKLVTASINFYKTA-EQVR Bombus_terrestris VKHRADALVSANHYDPKS-IREVAEDVTKRWQQLVTCAEERHKLVTASINFYKTA-EQVR Nasonia_vitripennis VKHRADALVSANHYDPKS-IRDVAEDVTKRWQQLVTCAEERHKLVTASINFYKTA-EQVR Tribolium_castaneum VKYRADALINANHYDPQS-IREISEEVTKRWQQLVTCAEERHKLVTASLNFYKTA-EQVC Drosophila_melanogaster VKYRADALINANHYDPLS-IDEISDDVTKKWQQLVTYAEERHKLVTASINFYKTA-EQVC Drosophila_willistoni VKYRADALINANHYDPQS-IRDISDDVTKKWQQLVTYAEERHKLVTASMNFFKTA-EQVC Drosophila_grimshawi VKYRADALINANHYDPKS-IREISDDVTKKWQQLVTYAEERHKLVTASINFYKTA-EQVC Anopheles_gambiae VKYRADALMNANHYDPQS-IKDIAEDVTKKWQKLVTCAEERHKLVTASQNFFKTA-EQVC Anopheles_aegypti VKYRADALMNANHYDPQS-IKDIADEVTKKWQKLVTCAEERHKLVTASLNFFKTA-EQVC Culex_quinquefasciatus VKYRADALMNANHYDPQS-IKDIADEVTKKWQKLVTCAEERHKLVTASLNFFKTA-EQVC Pediculus_humanus IKHRSEALINANHYDPNS-IREIAEEVTKRWQQLVTCAEERHKLVTASSNFYKTA-EQVC Ixodes_scapularis IQQRAESLVQANHYDPAA-VRSVAETVDTWWHRMMTHAEDRHRMVTASLRFYKTA-EQAC Caenorhabditis_elegans IRFRELMENRLANRDEVVYH---NEAIQAKYCRLMNLCEDRNKLLKSAHGCYKTYETAVL Caenorhabditis_briggsae VRFRELMENRLANRDEVVHH---NEMIQTKYRRLMALCEERNKLLKSAHGCYKTYETAVL Loa_loa FLNKTDQLISSGGVDVRS-VDDLNEEVLNRWRRLVGVTEERNKLIKAGVVCYKTLHQGVM Brugia_malayi FLNKTDQLISSGGVDVRL-VDDLNEEVLNRWRRLVGVTEERNKLIKAGVVCYKTLHQGVM Ascaris_suum FFEKTEQLISSGDANARD-INDLNEKVKGKWRRLVGLTEERNKLIKAAISCYKTFQHGVT Schistosoma_mansoni CAARASYFLQQTTLNNTSTINSVAETVANRWQKLVYAAEERHKLLISATNWYRTS-DQVT Hydra_magnipapillata VCKSSEILIKEGHPDPIC-IKAIIDEVESKWHFLMKRSEERRAVVFSSYNFYRAT-DQVA Nematostella_vectensis VRQRAEKLIKDGHFEPET-IRACADAMTNRWQHLMERSENRKVLITASFNFFNAG-EAVG Trichoplax_adhaerens IYKEGTKLNESGLHNFET-CNNCINNIMESWDCLNRLCNLRDELLTTSVQFHEAS-EEIF Trio_Human SVLESLEQEYKREE--DWCGGA-----DKLGPNSETDHVTPMISKHLEQKEAFLKACTLA Trad_Human SVLESLEQEYRRDE--DWCGGR-----DKLGPAAEIDHVIPLISKHLEQKEAFLKACTLA Saccoglossus_kowalevskii ------------------------------------------------------------ Branchiostoma_floridae SVLESLEREYKRDE--DWCGGN--SERYNT--TEPD-PIAPIIGKHVEQKEAFLKACTLA Strongylocentrotus_purpuratus SVLEDLEREYTREE--DLCGGGSGDRSPPQ--VSDA-DIAKHMSRHQDQKESFLRACTMA Harpegnathos_saltator SVLDSLEREYKRDE--DWCAGG-----------EKGAQVPTLLGKHQEQKEAFLKACTLV Apis_mellifera SVLDSLEREYKRDE--DWC-----A---SG--EKAT-QVPTLVGKHQEQKEAFLKACTLV Bombus_terrestris SVLDSLEREYKRDE--DWC-----A---SG--EKAT-QVPTLVGKHQEQKEAFLKACTLV Nasonia_vitripennis SVLDSLEREYKRDE--DWCVGG-----------EKANQVPNYITKHQEQKEAFLKACTLV Tribolium_castaneum SVLDSLEREYRRDE--DWCATG-------QPNVDKATSISQLINKHQEQKEAFLKACTLA Drosophila_melanogaster SVLDSLEREYKRED--DWCDGG--G---GS--DKAQ-AIVQLISKHQEQKEAFLKACTLA Drosophila_willistoni SVLDSLEREYKREE--DWCGGG--GSGSGS--EKVQTSVIQHMSKHQEQKEAFLKACTLA Drosophila_grimshawi SVLDSLEREYRRED--DWCGGG--G---SS--DKAQ-TIVQLISKHQEQKEAFLKACSLA Anopheles_gambiae SVLDSLEKEYRREE--DWCGGG--G---ST--DKGQ-QIVQLISKHQEQKEAFLKACTLA Anopheles_aegypti SVLDSLEKEYRREE--DWCGGG--G---ST--DKGQ-QIVQLISKHQEQKEAFLKACTLA Culex_quinquefasciatus SVLDSLEKEYRREE--DWCGGG--G---SS--DKGQ-QIVQLISKHQEQKEAFLKACTLA Pediculus_humanus SVLDSLEREYKRDE--DWCSSE------KVVSGDKIVAIAEHINKHQEKKEAFLKACTLA Ixodes_scapularis -----LEREYRRDE--DWCAGG--EESEGT--NRGA-QLAQLLAKHQEKKEAFLKACTMA Caenorhabditis_elegans PILNQLESEYHSPTVTDWCAGC-----TSSIDADRAAYVADLLSKHMDYKERFGKGCTYA Caenorhabditis_briggsae PILNQLESEYHSPTVTDWCAGC-----PSTVHSDRASYVADLLSKHMDYKERFGKGCTYA Loa_loa PILDQLEKEYSMSS-KDWCQIR-----NGEDAKDRAHHMSSLLSKHMEYKERFLKGCSYG Brugia_malayi PILDQLEKEYSMSS-KDWCQIR-----NGEDAKDRAHHMSSLLSKHMEYKERFLKGCSYG Ascaris_suum PILDQLEKEYSVGSVKDWCMQK-----SDECAAERARYISELLSKHMDYKERFLKGCSYA Schistosoma_mansoni SVLWSLEKEYRREE--DWCQNE--KAINSG--DPTS-YLAQLSSKHAEQKEAFLKACMLA Hydra_magnipapillata KLLEKFSKDCKSDE--DPCSKL-----SDYDLKHKKEKLEACMKNTEPERKAVEEGCLKV Nematostella_vectensis SLMDRLVREYKTED-GDPCSKL--IETETT--KKLE-AMRAIVQSYDDDRESIVHGFSEV Trichoplax_adhaerens QVLSSAERDFSSGR--DPCDIA----SEFTGVTNKSEAIYELIAKHNKERDTIIAACGLV Trio_Human RRNADVFLKYLHRNSVN--------MPGMVTHIKAPEQQVKNILNELFQRENRVLHYWTM Trad_Human RRNAEVFLKYIHRNNVS--------MPSVASHTRGPEQQVKAILSELLQRENRVLHFWTL Saccoglossus_kowalevskii ------------------------------------------------------------ Branchiostoma_floridae RRNAETFLKYVQRSNLT----HGPSPNR----LRGPDTRVKSILENLLKQENQVLEYWTI Strongylocentrotus_purpuratus RRNAESFLKYLKKCNVY----SSQQGSTMADRTRGPEGYVKRILEELLLQEDKVLDHWTQ Harpegnathos_saltator RRTAETFLKYTNRSLQF----YSYQAN-----SVGSENKVKNILEELLSKENKVLEYWTQ Apis_mellifera RRTAETFLKYTNRSLQF----YSYQAN-----SAGSENKVKNILEELLSKENRVLEYWTQ Bombus_terrestris RRTAETFLKYTNRSLQF----YSYQAN-----SAGSENKVKSILEELLSKENRVLEYWTQ Nasonia_vitripennis RRTAETFLKYTNRSLQF----YSYQTT-----GVASENKVKSILEELLSKENKVLEYWTQ Tribolium_castaneum RRTAETFLKYTTRSLQF----YNYSNT-----TSNHETRVKGILEKLLSQENKVLEHWTQ Drosophila_melanogaster RRTAETFLKYANRSQQC----YQY--------KGNCEGHVKSKLDKLLTQENQVLDYWTL Drosophila_willistoni RRTAETFLKYANRSQQY----YQF--------KGNCEAHVKSKLDKLLTQENQVLDYWTM Drosophila_grimshawi RRTAETFLKYANRSQQY----YQYT-------QGNCEEHVKTKLDKLLTQEYQVLEFWTL Anopheles_gambiae RRTAETFLKYANRSLQF----YHVKPT-----TVNSESRVKSILEKLLAQETQVLEYWTQ Anopheles_aegypti RRTAETFLKYAARSLQF----YHIK-T-----TVNSESRVKSILDKLLTQETQVLEYWTQ Culex_quinquefasciatus RRTAETFLKYAARSLQF----YHIK-T-----TVNSESRVKSILDKLLTQETQVLEYWTQ Pediculus_humanus RRTAETFLKYTSRSLQY----YNYQGEAG---TRNAEQRVKGKLD-ILSQENKVLEYWTL Ixodes_scapularis RRNAETFLKYTARCSQH----CAGHGDS---NYRGPEAKVKALMEQLLKQENKVLEYWTV Caenorhabditis_elegans LRNGDFLLRYIRRSTVN------------QSERKRHETKIADMKNNIRERQSNILELWMQ Caenorhabditis_briggsae LRNGDFLLRYIKRANMK---------------------------SNIRERQSNILELWLQ Loa_loa QKTSEMFLKYIRRCEAS------------AEHIRLHETRLLALKENLRKRQMKILDLWMR Brugia_malayi QKTSEMFLKYIRRCEAS------------TEHIRIHETRLLALKENLRKRQMKILDLWMR Ascaris_suum QKTSELFLKYIRRCEAP------------AEHVREHETRMLARKVDLRERQLKILDLWTR Schistosoma_mansoni RRTSDLFSKYLHRQPTS----TTG--------RVEVEEKIRLAMTELMAKEKAVLEAWAV Hydra_magnipapillata KESSEEFLKNVLPA-------SSGFPLIVDGSIGRLEIIVHDLVEQVISQETYVLKQLQL Nematostella_vectensis KYTADSYLNMITAREVH----VDGS-------YDRAEQQVKDVMDVLKVQEQVVMDLWGV Trichoplax_adhaerens RVYSTNLLSLIQAIDTYANEEAINETSKDDIVTSSSREHPRLIIEQLRRREGYVLNLWRS Trio_Human RKRRLDQCQQYVVFERSAKQALEWIHDNGEFY---LSTH-TSTGSSIQHTQELLKEHEEF Trad_Human KKRRLDQCQQYVVFERSAKQALDWIQETGEFY---LSTH-TSTGETTEETQELLKEYGEF Saccoglossus_kowalevskii ------------------------------------------------------------ Branchiostoma_floridae RKKRLDQCQQYVLFERSAKQALDWIHDTGEFY---LSTH-INVGDNREETEALLKEHNEF Strongylocentrotus_purpuratus KKKRFDQCLQYVLFEASARQALNWIHDTGEFY---LSTH-TKLGEDKEETEGLLTEYNEF Harpegnathos_saltator RKKRLDHCQQYVLFERSAKQALEWIRETGELY---LATH-TNVGKNRIENEQLLQEHNEF Apis_mellifera RKKRLDHCHQYVLFERSAKQALEWIRETGELY---LATH-TNVGKNRIENEQLLREHNEF Bombus_terrestris RKKRLDQCHQYVLFERSAKQALEWIRETGELY---LATH-TNVGKNRIENEQLLREHNEF Nasonia_vitripennis RKKRLDQCHQFVLFERSAKQALEWISETGELY---LATH-ASAGRNRAENEQLLHEHNEF Tribolium_castaneum RKKRLDQCQQFVLFERSAKQAIEWIHDTGECY---LTTHATNLGNNIEETESLLREHNEF Drosophila_melanogaster RKKSLDQCQQFVLFERSAKQAIEWIHNTGEAY---LSSRSNLVGISKEETEGLLKEHNEF Drosophila_willistoni RKKCLDQCQQFVLFEKSAKEAIEWIHNTGEGY---LLSRSNLVGITKEETEGLLREHNEF Drosophila_grimshawi RKKSLDQCQQFVLFERSAKQAIEWIHNTGEGY---LSSRTNLVGISREETESLLKEHNEF Anopheles_gambiae RKKRLDQCQQFVLFERSAKQAIEWIHDTGEAY---LSSRKNKLCSSREESELLLREHNEF Anopheles_aegypti RKKRLDQCQQFVLFERSAKQAIEWIHDTGEAY---LSSRNNKLCSSREETEVLLREHNEF Culex_quinquefasciatus RKKRLDQCQQFVLFERSAKQAIEWIHDTGEAY---LSSRNNKLCSSREETEVLLKEHNEF Pediculus_humanus RKKRLDQCQQYLLFERSAQQALEWIRDKGDLY---LSTH-TSVGQNKDETETLLSEHNEF Ixodes_scapularis RKKRLDQCQQYVLFERSAKQALGWIKDTGEHY---LTSH-NSVGDSREETERLLKEHNEF Caenorhabditis_elegans KKLLLEGCQSFIFIEASAKELLEFMKGEG------NRKLKHFEKKGRRESTDDDDEFAKF Caenorhabditis_briggsae KKSLLEGCQNFIAIEATAKDLLKFMTGEG------NEKLKQFEKRGRGELNDEDDEFAKF Loa_loa KKQQLDRCHEACLLEATAAENNEWIAVEGEAFLK-QCLERRLNLADRESLEAYMDEYMTF Brugia_malayi KKQQLDRCHEACLLEATATENAEWIAVEGETFLK-QCLERQLNMANRENLEAYMDEYMTF Ascaris_suum KKQQLDRCQQSVLLEATAKQNLEWINTTGEAFLS-HCYEGQLRNATREELDAYLEEYTTF Schistosoma_mansoni RRRRLDDCTYFMNLKRQIEDLLERVHNVQESIINKSTGFSNSMCLSNINPSLLQEVYRAC Hydra_magnipapillata RKTVVAGCVEYVLFQEEVEQVLELITEQGTVVSEGFKALDEVISSEGVESSLYVQKQEEY Nematostella_vectensis RKTMAEHCVQYLELETSAKEALDWIHENGEFY---LSSH-PNDGDTEAETRMFLKEHHEF Trichoplax_adhaerens HMISLEHCKEFIIFDTEAKKTLNTLHESNIFH---IPMNLNYEKLTESEAKLHLKLFREN Trio_Human QITAK---QTKERVKLLIQLA--DGFCEKG--HAHAAEIKKCVTAVDKRYRDFSLRMEKY Trad_Human RVPAK---QTKEKVKLLIQLA--DSFVEKG--HIHATEIRKWVTTVDKHYRDFSLRMGKY Saccoglossus_kowalevskii ------------------------------------------------------------ Branchiostoma_floridae KGTAK---ETREKVKLLLQVA--DSFVEKG--HSHASSIKSWVTAVDKRYKDFSSRMDKY Strongylocentrotus_purpuratus KSAAK---ENGEKVKLLLRLA--DSQLEKG--QSHATRIKSWVSAVDKRYRDFSLRMDKY Harpegnathos_saltator KGAAR---ETREKVKLIIQLA--DNLVDKG--HAHSAAIKQFVAEVDQRYKDFSARMDCY Apis_mellifera KGAAK---ETRERVKLLIQLA--DNLVEKG--HAHAVAIKQSVAEVDQRYKDFSTRMDCY Bombus_terrestris KGAAK---ETRERVKLLIQLA--DNLVEKG--HAHAAAIKQSVAEVDQRYKDFSTRMDCY Nasonia_vitripennis KGAAK---ETRERVKLLIQLA--DNLVEKG--HAHAAAIKQSVAEVDQRYKDFSMRLDCY Tribolium_castaneum KGTAK---ETRERVKLLIQLA--DSLVEKG--HAHASSIKQWVAAVDNRYKDFSSRMEQY Drosophila_melanogaster RSTAK---ETRERVKLLIQLA--DSLVEKG--HAHASDIKQWVASVDQRYKDFSNRMDSY Drosophila_willistoni RSTAK---ETRERVKLLIQLA--DTLVEKG--HAHATDIKQWVASVDQRYKDFSNRMDSY Drosophila_grimshawi RSTAK---ETRERVKLLIQLA--DSLVEKG--HAHASSIKQWVASVDQRYKDFSNRMDSY Anopheles_gambiae KSTAK---ETRERVKLLIQLA--DTLVEKG--HAHASSIKQWVATVDYRYKDFSQRMEIY Anopheles_aegypti KGTAK---ETRERVKLLIQLA--DSLVEKG--HAHASSIKQWVATVDNRYKDFSSRMELY Culex_quinquefasciatus KGTAK---ETRERVKLLIQLA--DSLVEKG-HHAHASSIKQWVATVDNRYKDFSSRMELY Pediculus_humanus KGKAK---ETRERVKLIIQLA--DNLVENG--HAHANAIKQWVAAVDNKYKDFSSRMNKY Ixodes_scapularis KGNAK---ETREKVRLLLQLA--DSLVERG--HAHASAIKCWVAAVDQGYKDFSLRMTST Caenorhabditis_elegans KSEVK---QKKTDIQTFLMLSTNETMSRGV----HGDEIDRCIEQVKDEFSRFSRRVGDC Caenorhabditis_briggsae KLEVK---QKKTEIQTFLLCS--DESMVRG---VHGDQVERCIEQVKEKFNQFSRRVGDC Loa_loa KAEAK---QKRLKVRMMLELA--EKFLSTL--DHHCNAIERKMFDVRSSYEHFSMRLADY Brugia_malayi KAEAK---QKRLKVRMMLELA--EKFLSVL--DHHCDAIERKMLDVRSSYEHFSMRLADY Ascaris_suum KVDAK---QQRAKARMMLQLA--ERFLKGARDQLHTNEVERWMHAVRARFEQFSVRLAEY Schistosoma_mansoni ASLESMIASSSPLSPGHATQM--ESLLQRL--RLCDTQSNTSSTVSGKGFKD-SQKLDHQ Hydra_magnipapillata QKIFE---DIHKKVKDLLEQA--SLLINKT--HFHRTNISDLANAINMRYKDLALHMKHY Nematostella_vectensis KEAAE---EIRDKVRTMLQQA--ESLVTKS--CHHGDGIRQWATAVEKRYKDFSSRMSKY Trichoplax_adhaerens EASLK---EMYRTIENLLEDG--VELIENK--HNHADNVKAMMDSLETNYYDCDYNMSKH Trio_Human RTSLEKALGIS------------------------------------------SDSNKSS Trad_Human RYSLEKALGVN---------------------------------------------TEDN Saccoglossus_kowalevskii ------------------------------------------------------------ Branchiostoma_floridae RHKLEQALGVE-----------------------------------------SELAPSEN Strongylocentrotus_purpuratus RVQLEGKLGLS------------------------------------------------- Harpegnathos_saltator KTQIEGDLGIQ--------------------------------------------SDEGH Apis_mellifera KTQIEEDLGIQ-------------------------------------------SDDG-Q Bombus_terrestris KSQIEEDLGIQ-------------------------------------------SDDG-Q Nasonia_vitripennis KTTIEDDLEIQ--------------------------------------------SDEGP Tribolium_castaneum RQQLEDTLGIQ-------------------------------------------AEESEK Drosophila_melanogaster CEQLEKSLGMS------------------------QQ--QLLLG-SDGNSSISSSS---G Drosophila_willistoni CEQLEKSLGMS------------------------QQ--QLLLGSSDANSSISSTS---G Drosophila_grimshawi CEQLEKSLGMA------------------------KQPLHLMMMQPDADANSSSSTPGVS Anopheles_gambiae RSNLEKSLGLPG------------------------------------------TSAGSA Anopheles_aegypti RTNLEKSLGLPGIQQQDDNNSSS-----------------------------TSSTTATG Culex_quinquefasciatus RANLEKSLGLPGIQQQDDNNSSSSINSSNSSLNCKSISSSTTSVSTSSTSGISSASSTTA Pediculus_humanus RGQLENSLGIQ-------------------------------------------AKAELK Ixodes_scapularis GVSWRGSWGSR--------------------------------SRWASLCCGDTFLQPSS Caenorhabditis_elegans EVVLRGENGST---------------------------------------------QSSK Caenorhabditis_briggsae EVVLRGENGGS---------------------------------------------SSSK Loa_loa ENLLSGALGRK------------------------------------------LDVNKAK Brugia_malayi ENLLSGALGRK------------------------------------------LDVNKAK Ascaris_suum ETLLFTAVGRK------------------------------------------PEFCKAK Schistosoma_mansoni SSELKKSITTP---------------------------------------SSKVDIQPGS Hydra_magnipapillata RKSLEIKFGYS---------------------------------------LPELEDESEW Nematostella_vectensis RVRLETKLGYP-------------------------------------------TIDQEV Trichoplax_adhaerens QFLLEAITKGE--------------------------------PTTEYPDKHTYLHKMSS Trio_Human KSLQLD----IIPASIPGSEVKLRDA---------AHELNEEKRKSARRKEFI--MAELI Trad_Human KDLELD----IIPASLSDREVKLRDA---------NHEVNEEKRKSARKKEFI--MAELL Saccoglossus_kowalevskii ------------------------------------------------------------ Branchiostoma_floridae KDLSLDGKGSEGKGSDSSLEVKLRDS---------AKDSNEEKRKSARRKEFI--MAELL Strongylocentrotus_purpuratus ----------HEDDGNLSLDHRKSDSSLELKFRDAAKGGGEEKRKSARKREFI--MAELL Harpegnathos_saltator KDLSID------RNSDPLLEEKIKGKD--------LKELNEEKRRSARRKEFI--MAELL Apis_mellifera KDLSID------RNSDPLLEEKIK---GKD-----LKELNEEKRRSARRKEFI--MAELL Bombus_terrestris KDLSID------RNSDPLLEEKIK---GKD-----LKELNEEKRRSARRKEFI--MAELL Nasonia_vitripennis KEITID------RNSDPLLEEKIKGKD--------LKELNEEKRRSARRKEFI--MAELL Tribolium_castaneum KELSID------RNSDPSLEAKVKEAAAKD-----LKELNEEKRRSARRKEFI--MAELL Drosophila_melanogaster -----D------RHSDPTLEAKLNSSNKE------NKEINEEKRKSARRKEFI--MAELM Drosophila_willistoni STNSAD------RHSDPTLEAKLTGASVKSAV---SKEINEEKRKSARRKEFI--MAELM Drosophila_grimshawi SSNSTD------RHSDPTLEAKLTTSASSAA----SKEINEEKRKSARRKEFI--MAELM Anopheles_gambiae GGSVLE-----YRHSDPSLETKLNAAAAGAGA----KEINEEKRKSARKKEFI--MAELL Anopheles_aegypti GNSVLE-----YRHSDPSLETKLNAAAAGPGAVGVPKEMNEEKRKSARKKEFI--MAELL Culex_quinquefasciatus NASVLE-----YRHSDPSLETKLNAAAAGPGGVGVPKEMNEEKRKSARKKEFI--MAELL Pediculus_humanus QDLSID------RNSDSSLDNKVKEPTSKD-----LKELNEEKRRSARRKEFI--MAELL Ixodes_scapularis LQLSLD------RNSDPNLESKVKEST--------VKELNEEKRKSARRKEFI--MAELL Caenorhabditis_elegans DEFSLD------RHSDTAIFNEKK-----------INERREENRKMLEP------MRELI Caenorhabditis_briggsae DEFSLD------RHSDTAIFNEKA-----------ISEQRAENRKVLEP------MRELI Loa_loa DEFSLD------RKSDSNIEAKIE-----------VEQLANEEKRKMRRNIYVEPMMELI Brugia_malayi DEFSLD------RKSDSNIEAKIE-----------VERLANEEKRKMR-----EPMMELI Ascaris_suum EELSLD------RQSDSSLEAKI-----------------EGDRKMREP------MMELI Schistosoma_mansoni KTLELE------PDSMTNESYLVSSAAA-------ASGTTQEQRRLARRRENL--LRELI Hydra_magnipapillata PSLSLL------RVQSAEISNVTRRDVSNDSG---IHEMTEEKRRSVKRIEFV--IKELI Nematostella_vectensis RILA--------PQDQPAFALRETSKDSG------IHEMTEEKRRSAKRKEFI--VNELL Trichoplax_adhaerens RASLSSL---RSDLQRSGSRGSLKRQ---------LSE-DDEKQRIERRKKFV--INELI Trio_Human QTEKAYVRDLRECMDTYLWEMTSG--VE-----EIPPGIV-NKELIIFGNMQEIYEFHNN Trad_Human QTEKAYVRDLHECLETYLWEMTSG--VE-----EIPPGIL-NKEHIIFGNIQEIYDFHNN Saccoglossus_kowalevskii ------------------------------------------------------------ Branchiostoma_floridae QTERVYVRDLECCIKNYLCEMTAS--VQ-----EVPVGLS-GRESVIFGNIEEIYDFHNN Strongylocentrotus_purpuratus QTEQAYVRDLHCCITNYMCEMMAS--VV-----EVPGGII-GKEHIIFGNIEEIYAFHKD Harpegnathos_saltator QTERTYVKDLETCIRCFLDETRCG--KG-----NVPPGLQ-SRESIIFSNIEEIHQFHSN Apis_mellifera QTERTYVKDLETCIRCFLEETRCG--KG-----NVPSGLQ-GRESIIFSNMEEIHQFHSN Bombus_terrestris QTERTYVKDLETCIRCFLEETRCG--KG-----NVPSGLQ-GRESIIFSNMEEIHQFHSN Nasonia_vitripennis QTERTYVKDLETCIRCFLEETRAN--KS-----NVPQGLQ-GRESIIFSNMEEIHRFHCD Tribolium_castaneum QTERTYVKDLETCIKCFLNDMRQG--------NNCPAAIH-GKDEIIFGNIEEIYNFHNS Drosophila_melanogaster QTERAYVNDLATCIKCFLEEFRAG--K------SVPSALI-GQEDVIFGNIKEIHHFHQK Drosophila_willistoni QTERTYVNDLATCIKSFAEEFRNG--RN-----TVPAGLV-GQESVIFGNIREIHHFHQK Drosophila_grimshawi QTERAYVNDLATCIKCFLEEFRSG--R------NVPSPLL-GQEDIIFGNIREIHHFHQK Anopheles_gambiae QTERTYVKDLETCISVFLRELKSG---Q-----QVPPNLV-GREHILFANIEDIYQFHEK Anopheles_aegypti QTERTYVKDLETCINVFVNELKSG---V-----NVPPNLL-GKEHILFSNIVDIYQFHEK Culex_quinquefasciatus QTERTYVKDLETCINVFVSELKSG---V-----NVPTNLV-GKEHILFSNIEDIFAFHEK Pediculus_humanus QTERTYVKDLETCIKVFLNEMRTS---S-----SLPIHIH-NKSDVVFGNMEEIYEFHNG Ixodes_scapularis QTERSYVKDLETCIHTYMAELKNP--DI-----SRPPGIV-GKELVLFGNMEEIYEFHNS Caenorhabditis_elegans QSERDYIKDLERCVNIYVKEFDQA--AK-----NGTIPTLNPLKYEIFGNIEKIFKFHND Caenorhabditis_briggsae QSEKDYIKDLEKCISIYVAEFDQA---------TKNGSIPTLQKYDIFGNIEKIYQFHHD Loa_loa KSEKDYIEDLHKCIKYYLSAYRAV--ND-----TLPIAIR-DKEKEIFSNIEQLYKFHNE Brugia_malayi KSEKDYIEDLHKCIKYYLSAYRAA--ND-----TLPLAIR-GKEKEIFSNIEQLYKFHNE Ascaris_suum KSEKDYIEDMRNCICYYLSAYRDA--GN-----SVPATIR-NKEKELFGNIEQLYKFHSE Schistosoma_mansoni QTERLYIQSLEQCIDTYRKGLVSP--PKMLTA-QVPSGLI-GQVDTVFGNIPLIYEFHKQ Hydra_magnipapillata QTEKAYVDDLRCCIEVFKLDARLNFLLPTYNNPQFPEMLQ-GQQHIIFGNIERIFEFHSS Nematostella_vectensis QTERAYVGDLKCVIEVVFPALRSS--AY-----DVPAGLV-GKESIIFGNIQDIYKFHSN Trichoplax_adhaerens TTEQTYVKDLEQVINIYMEAMHGP---------DVPAELY-GRDEVIFGNIEEIYNFHKS Trio_Human IFLKELEKYEQLPEDVGHCFVTWADKF-QMYVTYCKNKPD-STQLILEHAGSYFDEIQQR Trad_Human IFLKELEKYEQLPEDVGHCFVTWADKF-QMYVTYCKNKPD-SNQLILEHAGTFFDEIQQR Saccoglossus_kowalevskii ------------------------------------------------------------ Branchiostoma_floridae VFLRELEKYEQFPEDVGHCFVTWAEKF-DMYVKYCKNKPD-SNQLLMEHAGNFFEDVQNK Strongylocentrotus_purpuratus VFLKELEKYESMPEDVGHCFVTWADKF-QMYVTYCKNKPD-SNALLVEHGGAFFDEMQKK Harpegnathos_saltator VFLRELEKYETMPEDVGHCFVTWAPKF-DMYVIYCKNKPE-SNQLLVTHGGTWFEELQRK Apis_mellifera IFLRELEKYETMPEDVGHCFVTWAPKF-DMYVTYCKNKPE-SNQLLVTHGGTWFEELQRK Bombus_terrestris IFLRELEKYETMPEDVGHCFVTWAPKF-DMYVTYCKNKPE-SNQLLVTHGGTWFEELQRK Nasonia_vitripennis IFLRELEKYETMPEDVGHCFVTWAAKF-DMYVTYCKNKPE-SNQLLVTHGGTWFEDLQRK Tribolium_castaneum IFLKELEKYETMPEDVGHCFVTWAQKF-DIYVHYCKNKPE-SNSLLVQHGGGYFEELQKK Drosophila_melanogaster IFLRELEKYETMPEDVGHCFVTWASKF-DMYVHYCKNKPT-SNNLLVQHGGSFFEELQRR Drosophila_willistoni IFLKELEKYETMPEDVGHCFVTWASKF-DMYVHYCKNKTT-SNNLLVQHAGTYFEELQRR Drosophila_grimshawi IFLRELEKYETMPEDVGHCFVTWAVKF-DMYVHYCKNKPT-SNNLLVQHAGNYFEELQRR Anopheles_gambiae IFLRELEKYETMPEDVGHCFVTWATKF-DMYVHYCQNKPQ-SMDYMVQHGGTYFDEVQRK Anopheles_aegypti IFLKELEKYETMPEDVGHCFVTWAAKF-DMYVYYCQNKPQ-SNDYMVQFGGSYFDEVQRK Culex_quinquefasciatus IFLRELEKYETMPEDVGHCFVTWAAKF-DMYVFYCQNKPQ-SNDYMVQFGGTYFEEVQRK Pediculus_humanus IFLKELEKYETMPEDVGHCFVTWAQKF-DMYVKYCKNKPD-SNSVLVNHAGTFFEDLQKK Ixodes_scapularis VFLKELEKYETMPEDVGHCFVTWAQKF-EIYVKYCKNKPE-SNALLIQHSRSFFEEIQHK Caenorhabditis_elegans KLLHELIKYENQPEAVGASFIVWIDLLNELYTEYCVNKEQKNHVIATPDAVSFFTGIRER Caenorhabditis_briggsae KLLPELVKYENQPEAVGASFTVWIDLLNELYIEYCVNKEQKNNVLATPEAKAFFTEIREK Loa_loa VFLPELTKHENDPEDVGYCFIFSVEMLNTLYTEYCVNKEQNNYVIALPEAVQFFSEIREK Brugia_malayi VFLPELIKHENDPEDVGYCFIFSVEMLNTLYTEYCVNKEQNNYIIALPEAMQFFSEIRET Ascaris_suum VFLPELIKYENDPEDVGYCFIFSVEILNSLYTEYCVNMEQNNYLITLPEAVQFFSEIREK Schistosoma_mansoni TFEPELAKYDFLPEDVGHCFVLHSDRLAELYVEYCVNNTE-STRLIIEHGQGYFQSLQLY Hydra_magnipapillata IFLKCLEKYEHSPENVGHAFIDWEDSF-HMYVDFCANKPD-SNALLIEHGENFFEDLQLK Nematostella_vectensis TFLQEMEKYETHPEDVGEAFIEWGETFVRFYVSYCKNKPF-SNSLLIEHGGNFFSDLQAS Trichoplax_adhaerens TFCNELTACIDSPENVGNCFISHAEHF-EMYVDYCRNKSR-SNTVVMEYGQTFFDDVQQR Trio_Human HGLANSISS--YLIKPVQRITKYQLLLKELLTCCEEGKG-EIKDGLEVMLSVPKRANDAM Trad_Human HGLANSISS--YLIKPVQRITKYQLLLKELLTCCEEGKG-ELKDGLEVMLSVPKKANDAM Saccoglossus_kowalevskii ------------------------------------------------------------ Branchiostoma_floridae HSMSLTIQS--YLIKPVQRITKYQLLLKDLLACCEEG-KGEIKDGLEVMLNVPKKANDAM Strongylocentrotus_purpuratus HNLGLSVQA--YIIKPVQRITKYQLLLKDLLATCEEG-RGEIQDALDVMLTVPKKANDAM Harpegnathos_saltator HRVEHPIAA--YLIKPVQRITKYQLLLKDLQACCQEGQG-EIKDGLEVMLNVPKKANDAL Apis_mellifera HRVEHPIAA--YLIKPVQRITKYQLLLKDLQACCQEG-QGEIKDGLEVMLNVPKKANDAL Bombus_terrestris QRVEHPIAA--YLIKPVQRITKYQLLLKDLQACCQEG-QGEIKDGLEVMLNVPKKANDAL Nasonia_vitripennis HRVEHPIAA--YLIKPVQRITKYQLLLKDLQACCQEGQG-EIKDGLEVMLNVPKKANDAL Tribolium_castaneum HKVEHPIAA--YLIKPVQRITKYQLLLKDLQSCCNEGQG-EIKDGLEVMLNVPKKANDAM Drosophila_melanogaster LEVDHPLPA--YLIKPVQRITKYQLLLKDLLSCCEES-HGEIKEGLEVMLNVPKKANDAM Drosophila_willistoni LEVEHPLPA--YLIKPVQRITKYQLLLKDLLSCCEES-HGEIKEGLEVMLNVPKKANDAM Drosophila_grimshawi LEVEHPLPA--YLIKPVQRITKYQLLLKDLLSCCEGS-HGEIKEGLEVMLNVPKKANDAM Anopheles_gambiae HKLEHSLPA--YLIKPVQRITKYQLLLKDLQSCCDEG-RGEIKDGLEVMLNVPKKANDVM Anopheles_aegypti HNLEHSLPA--FLIKPVQRITKYQLLLKDLQSCCDEG-QGEIKDGLEVMLNVPKKANDVM Culex_quinquefasciatus HKLEHSLPA--FLIKPVQRITKYQLLLKDLQSCCDEG-QGEIKDGLEVMLNVPKKANDVM Pediculus_humanus HRVEHPIAA--YLIKPVQRITKYQLLLKDLQSCCQEGQG-EIKDGLEVMLNVPKKANDAM Ixodes_scapularis HGVPHPIPA--YLIKPVQRITKYQLLLKDLLACCEDGVQGEIRDGLEVMLNVPKKANDAM Caenorhabditis_elegans HGLEINNEIASLLIKPVQRITRYRLLIEQLMRSCTDKTN-DLKEAYEVVCSVPRKVNDLI Caenorhabditis_briggsae HGLEIDNEITSHLIKPVQRITRYQLLISQLLRSCNDKAD-DLKDAYDVVCSVPRKANDII Loa_loa SGLEHSQDLSSLVIKPVQRITRYRLMLEQLLKNCKNNVD-EIREAYDVVVSVPRRANDLM Brugia_malayi SGLEHSQDLSSLVIKPVQRITRYRLMLEQLLKNCKHNVD-EIREAYDVVVSVPRRANDLM Ascaris_suum NSLEHNQNLQSFIIKPVQRITRYRLMLEQLLKNCKNNVE-EIKEAYDVVVSVPRRANDLM Schistosoma_mansoni FNLVEPLQS--YLIKPVQRVTKYQLLLRELRDCCDPAGIGEISEGLEAMLNVPKRANDAL Hydra_magnipapillata RGLGLSLAA--YLIKPVQRITKYQLLLKELVSSCDSDA--NLQLGLDVMLNVPRRANDAM Nematostella_vectensis YGHGLSISA--YLIKPVQRITKYQLLLKDLLTCCEGS-ENSLQAGLDVMLSVPRRANDAM Trichoplax_adhaerens SCCDVSLSS--YLIKPVQRMTKYQLLLKDLMDCVDSGKE-EIKASVEVMLSVPRRANDAM Trio_Human HLSMLEGF-D-ENIESQGELILQESFQVWDPKT-LIR-KGRERHLFLFEMSLVFSKEVKD Trad_Human HVSMLEGF-D-ENLDVQGELILQDAFQVWDPKS-LIR-KGRERHLFLFEISLVFSKEIKD Saccoglossus_kowalevskii ------------------------------------------------------------ Branchiostoma_floridae HLSMLEGF-E-------------------------------------------------- Strongylocentrotus_purpuratus HVSMLEGF-D-DYLRAHGEVILQDAFQVWDTKQ-IFR-KGRERHIFLFEMFLVFSKETKD Harpegnathos_saltator HLSLLEGC-D-VRIDTLGDVVLQDSFTVWDPKQ-LIR-KGRDRHIFLFELYFLFSKEVKD Apis_mellifera HLSMLEGC-D-VRIDTLGDVVLQDSFTVWDPKQ-LIR-KGRDRHIFLFELYLLFSKEVKD Bombus_terrestris HLSMLEGC-D-VRIDTLGDVVLQDSFTVWDPKQ-LIR-KGRDRHIFLFELYLLFSKEVKD Nasonia_vitripennis HLSLLEGC-D-VRIDTLGDVVLQDPFTVWDPKQ-LIR-KGRERHIFLFELYLLFSKEVKD Tribolium_castaneum HLSLVEGC-D-VSANKLGEVVLQDAFSVWDPKQ-LIR-KGRERHIFLFELYLLFTKEVKD Drosophila_melanogaster HLSLLENC-D-VSVDKLGEVVLQDAFQAWDTKQ-IIR-KGRERRVFLFELYLLFAKEVKE Drosophila_willistoni HLSLLENC-D-VSVDKLGEVVLQDAFQAWDTKQ-IIR-KGRERRVFLFELYILFAKEVKE Drosophila_grimshawi HLSLLENC-D-VSIDKLGEVVLQDAFQAWDTKQ-IIR-KGRERRVFLFELYLLFAKEVKE Anopheles_gambiae HLSLLEQC-D-MPIDNLGDVVLQDSFLVWDTKQILIK-KGRERHVFLFELYILFSKEVKD Anopheles_aegypti HLNLLEGC-D-IPIDNLGDVVLQDSFLVWDNKQILIK-KGRERHVFLFELYILFSKEVKD Culex_quinquefasciatus HLSLLEGC-D-VPIDTLGDVVLQDSFLVWDNKQILIK-KGRERHVFLFELYILFSKEVKD Pediculus_humanus HLSLLENC-D-ISLDKLGEVILQDTFQVWDPKQ-IIR-KGRERHIFLFELYLLFSKEVKD Ixodes_scapularis HLSLLDGC-D-VSLDQLGEVVLQDSFQVFDSRA-IIR-KGRERHIFLFELYLLFSKEMKD Caenorhabditis_elegans HYNCLDLK-D-FKVDELGPFVTQDTLTFWEPRA-YFKGRGKERQVFLFDISIVFAKRIEV Caenorhabditis_briggsae HFNCLEL--KNCNVDELGPFVTQDVLTVWEPRA-YFKGRGKERQVFLFDLSIVFAKRIET Loa_loa HLGNFENY---KKLGVLGDFVMQESFLVWDPKA-YFK-KGRERQVFLFELCVVFAKKTEL Brugia_malayi HLGNFENY-K--KLGVLGDFVMQESFLVWDPKA-YFK-KGRERQVFLFELCVVFAKKTEL Ascaris_suum HLGNFEGY---KELGVLGDFVMQESFIVWDPKA-YFK-KGRERQVFLFELCVVFAKKIEL Schistosoma_mansoni HLSMLQNLPEDVPLSSLGDVILQDQFTIWEPKQ-LIK-KSRERRVFLFDHCLVLAKEAAN Hydra_magnipapillata YLCMIRGF-DEGSLESLGKILLQDSFSVWDPKH-ILK-KGKDRHVFLFEQALLFCKEVKD Nematostella_vectensis YVNMLHGL--EENLDHLGRIILQDAFTVFDPKL--LRRKGKDRHVFLFEQALVFSKETKD Trichoplax_adhaerens HAGLLTGV-D-SDIEGLGKVIMQDECLLMDSKS--IRRKEKERHLFLFEKALVLSKQVKD Trio_Human SSGRS--KYLYKSKLF------TSELGVTEHVEGDPCKFAL--WVGR-----TPTSDNKI Trad_Human SSGHT--KYVYKNKLL------TSELGVTEHVEGDPCKFAL--WSGR-----TPSSDNKT Saccoglossus_kowalevskii ------------------------------------------------------------ Branchiostoma_floridae ----------------------TSDLGVTEHIEGDPCKFAL--WTG----RQPT-SDNRI Strongylocentrotus_purpuratus STGKT--KYMYKSKMD------MSDLGITEHIEGDHCKFAL--WTG----RTPS-SDNRI Harpegnathos_saltator SAGKV--KYIYKNRLM------TSELGVTEHIEGDECKFAV--WTGR-----APTNDTRV Apis_mellifera SAGKV--KYIYKSRLM------TSELGVTEHIEGDECKFAV--WTG----RAPT-SDTRV Bombus_terrestris SAGKV--KYIYKSRLM------TSELGVTEHIEGDECKFAV--WTG----RAPT-SDTRV Nasonia_vitripennis SAGKV--KYIYKSRLM------TSELGVTEHIEGDECKFAV--WTGR-----APTSDTRV Tribolium_castaneum SAGKV--KYIYKNKLM------TSELGVTEHMEGDECKFAV--WTGR-----APISDYRI Drosophila_melanogaster SN-VV--KYQFKSKLM------TTDMGITEHIEGDETKFAV--WTG----RSPMLSDCRI Drosophila_willistoni SN-AV--KYIFKSKLL------TNDVGITEHIEGDETKFAV--WTG----RSPMLSDCRI Drosophila_grimshawi SN-VV--KYQFKSKLM------TTDMGITEHIEGDETKFAV--WTG----RSPMLSDCRI Anopheles_gambiae TNGTV--KYIYKNKLL------TSDFGVTEHIEGDECKFAI--WTG----RAPILSDYRI Anopheles_aegypti TNGVV--KYIYKSKLL------TSDFGVTEHIEGDECKFAI--WTG----RAPMLSDYRI Culex_quinquefasciatus TNGTV--KYIYKSKLL------TSDFGVTEHIEGDECKFAI--WTG----RAPMLSDYRI Pediculus_humanus SNGKA--KYIYKNKLM------TSELGVTEHIEGDECKFAV--WTGR-----APISDYRI Ixodes_scapularis PNGKV--KYVYKQKLM------TSEVGITEHVEGDECKFAV--WTAVWTEHGPT-SENKI Caenorhabditis_elegans SPKNI--KYVIKGKPLP-----LSEVSIVEHVEGDTCRFGL--RVGT-----VSSNDNRI Caenorhabditis_briggsae SPKNF--KYVIKGKPLP-----LSDVSIVEHVEGDSCRFGL--RVGS-----NHSNDNRT Loa_loa SSRAI--KYTYKTHLMASAFIFLAEINVCEHVEGDASKFAL--RQGN-----EPNTEMRT Brugia_malayi SSRAI--KYTYKTHLMAS----LAEVNVCEHVEGDASKFAL--RQGN-----EPNTEMRT Ascaris_suum STRAI--KYVYKSRLM------LAEINVCEHVEGDPSKFAL--RQGS-----VPSNELRT Schistosoma_mansoni QPGEHKSKYIYKSRLL------LADCNITEHIEGDQCKFAL--WTG----RIPPIHEYRM Hydra_magnipapillata SNGKC--TFTFKFKMK------TNELGLTEHVAEDSSKFAV--WTGQ-----PPFTEEKR Nematostella_vectensis NDGKV--SYLYKYKLK------TSELGVTEHIAEDPCKFAV--WTGK-----PPQSEDKR Trichoplax_adhaerens GDGNV-KNYIFKSRIM------VADIASVGRIENEPLKFVIIS---------KRASDSKL Trio_Human VLKASSIENKQDWIKHIREVIQERTIHLKGAL---------KEPIHIPKTAPATRQKGRR Trad_Human VLKASNIETKQEWIKNIREVIQERIIHLKGAL---------KEPLQLPKTPA-------K Saccoglossus_kowalevskii ------------------------------------------------------------ Branchiostoma_floridae ILKASSLEVKQSWVKKIRETVQERQMHITAALNDALQRNDSRQQPSLLKAAA-------K Strongylocentrotus_purpuratus VLKAQSMDNKQEWIRRLREVVQDRQIHPRAALIDTVKFSKTSFTKSAPSTSS-------S Harpegnathos_saltator VLRANSMDAKQLWVKRLREVIQETYFSL-----------------SMPKSPA-------- Apis_mellifera VLRANSMDAKQLWVKRLREVIQETYFS----L-------------SMPKSPA-------K Bombus_terrestris VLRANSMDAKQLWVKRLREVIQETYFS----L-------------SMPKSPA-------K Nasonia_vitripennis VLRSNSLESKQLWVKRLREVIQETYFSL-----------------SMPKSPA-------- Tribolium_castaneum VLRASSLETKQLWVKKLREVIQETYFSGALPL-------------SLPKSPA-------- Drosophila_melanogaster VLKATSLETKQIWVKKLREVMQETCFSGTS-L-------------TLPKSPA-------K Drosophila_willistoni VLKANSMETKQIWVKKLREVMQETFFSDTS-L-------------TLPKSPA-------K Drosophila_grimshawi VLKANSLETKQIWVKKLREVMQETCFSGTS-L-------------TLPKSPA-------K Anopheles_gambiae VLKANSLETKQLWVKRMREVMQETYFSGTS-F-------------SLLKSPA-------K Anopheles_aegypti VLKATSLETKQMWVKRLREVIQETYFSGTS-F-------------SLLKSPA-------K Culex_quinquefasciatus VLRANSLETKQMWVKRLREVIQETYFSGTS-F-------------SLLKSPA-------K Pediculus_humanus VLKASCLDVKQTWVKKLREVIQETYFSTALPL-------------SLPKSPA-------- Ixodes_scapularis ILKASSLETKQTWVKKLRQVIQETYFNSALST-------------LNLNKSS-------K Caenorhabditis_elegans DLKANNHHTKVKWVQKIRDLTAGMLPLGLGVS-----EAYSVGTLSTARSVS-------V Caenorhabditis_briggsae DLKASTESTKVKWVLKIRELTTGLLPLGTLGL---------GVSPAISATTLSTARSVSH Loa_loa ELKAASEQCKVHWVKKIRELMQGLMTANFDMR----------------QIPA-------R Brugia_malayi ELKAASEQCKVHWVKKIRELMQGLMTANFGTNVIIIEEKNSSKALRDMRQVSA------R Ascaris_suum ELRAANEQCKVHWVKKIRELMQGLMTANLDMR-------------HVPMGRT-------- Schistosoma_mansoni VLKAGTLELKQNWVRALREVMRERVFSVQSLY------------QHQNPNPNSTNLFDDS Hydra_magnipapillata IIKAESNVVKLMWVREIRELMQQFQFGMLVPQ--------TSFYPQSPKKGSKNRKSTSV Nematostella_vectensis VIKAANIEVKQLWVKELRELIQQFQFGILKER---------------------------- Trichoplax_adhaerens IFKSYSESVTEEWIKRLKPLVYIGIAKLRGNV---------SIQSRPGSGSE-------- Trio_Human DGEDLDSQGDGSSQPDT-----------------ISIASRTSQNTLDSDK---------- Trad_Human QRNNSKRDGVEDIDSQGDGSSQPDT---------ISIASRTSQNTVDSDK---------- Saccoglossus_kowalevskii ------------------------------------------------------------ Branchiostoma_floridae LLTQNKSPREPSIGGEESESVHSTEEGSVHSMEQQETGSVTSATTIDSDK---------- Strongylocentrotus_purpuratus LSQKSSRSYNSEESLNDESLL--------GGYDRNSITSVSTNNTNYTDN---------- Harpegnathos_saltator ---KKSSSQRSSRDLEECASL----DDSVENLDRNSLASFGSTNTTDSDKGSAPARNSGG Apis_mellifera -KSS--SQR-SSRDLEECTSL----DDSVENLDRNSLASFGSTNTTDSDK---------- Bombus_terrestris -KSS--SQR-SSRDLEECASL----DDSVENLDRNSLASFGSTNTTDSDK---------- Nasonia_vitripennis ---KKSSSQRSSRDLEECASL----DDSVENLDRNSLASFGSTNTTDSDK---------- Tribolium_castaneum --KLKPHSQRSSRDLEECNSL----DESVENLDRNSLTSFGSGNTTDSDK---------- Drosophila_melanogaster HSGS--SQR-SSRDLDE--QL----TE--NDHDRCSLASFGSGNTTDSDNK--------- Drosophila_willistoni HSGS--SQR-SSRDLDE--PL----TE--NDHDRCSLASFGSGNTTDSDNK--------- Drosophila_grimshawi KSGS--SQR-SSRDLDE--PL----TE--NDHDRCSLASFGSGNTTDSDNK--------- Anopheles_gambiae VSGKNLGQR-LSKDIDD--TL----ND--NDQDGSSLASFGSGNTTDSEK---------- Anopheles_aegypti VGNKPLGQR-LSKDIDD--TL----ND--NDQDGSSLASFGSGNTTDSEK---------- Culex_quinquefasciatus VGAKQLGQR-LSKDIDD--TL----ND--NDQDGSSLASFGSGNTTDSEK---------- Pediculus_humanus -KGKSGSSQRSSRDMEDNGSLDENAER-------VSVASFSSGNTTDSDK-------RCQ Ixodes_scapularis LTSKLFSNR-SSRDLEDSSQD----EGLTDLQERVSVASFGSSNTTDSEK---------- Caenorhabditis_elegans RSGASTSSGGENRQSQDVESL---------------LRHRYSVHSCDSEQ---------- Caenorhabditis_briggsae RSGASTSSGGDNRQSQDVDSL---------------LHHRYSVHSCDSEQSSEVWIVTAD Loa_loa NSGATTTTSVSDRTSKDSDSLP--TSNEDRNSLRSCTSSS-SNHNLEIDMLVSCQSLILV Brugia_malayi NSSATTTTSVSDRTSKDSDSLP------------TSNEDRNSLRSCTSSSSNHNLEV--- Ascaris_suum RTSAASSSDRTSKDTDLPGSADER----------NSLRSRASSSDNLEGH---------- Schistosoma_mansoni TEMLDTFYILENYQAEKDNEISVSAHQIVQLLHRCDEPILPSIENNDNDSSNGSIVKFDP Hydra_magnipapillata ADMSMTSDGGCNRSSGDFDT--------------ATICSRTSLENCARTD---------- Nematostella_vectensis --TKKRRWRRSSLDFAMFSPLS----PTFYHVSPTELCSFSYKVLELSQDN--------- Trichoplax_adhaerens ------------------------------------VFVSPEDSDGDYPR---------- Trio_Human --------------------------------------------------------LSGG Trad_Human --------------------------------------------------------LSGG Saccoglossus_kowalevskii ------------------------------------------------------------ Branchiostoma_floridae ----------------------------------------------------FESGSSGH Strongylocentrotus_purpuratus ---------------------------------------------------SDRDSTRMS Harpegnathos_saltator SDGGSGGVVVVVVVVVVVVVVVVAVEVTVVVVVMVVVVLVVVLMVVVVEEEVMVVVTGVV Apis_mellifera --------------------------------------------------------TGVA Bombus_terrestris --------------------------------------------------------TGVA Nasonia_vitripennis --------------------------------------------------------TGVA Tribolium_castaneum -----------------------RIGSCRRTCIVPLITSFSFSYQIGDMALAEELEQAGV Drosophila_melanogaster --------------------------------------------------------LGNQ Drosophila_willistoni --------------------------------------------------------LGNQ Drosophila_grimshawi --------------------------------------------------------LGNQ Anopheles_gambiae --------------------------------------------------------GGLA Anopheles_aegypti ------------------------------------------------------------ Culex_quinquefasciatus --------------------------------------------------------VSGT Pediculus_humanus MMATGEKPQKSRRKISLPWFRQGSVNKPHHGLTRQHTIDTPGGFHARFLHRQHSQVEPVV Ixodes_scapularis ------------------------------------------------------------ Caenorhabditis_elegans -----------------------------------------------------------S Caenorhabditis_briggsae FDGQTEGHLTVHKGDRVEIVEDQATDCAEYIQVVLCDQPTKHGLVPASIIVP----R--- Loa_loa VLLELGIRNDFRFF---------------------------------------------- Brugia_malayi ------------------------------------------------------------ Ascaris_suum ------------------------------------------------------------ Schistosoma_mansoni NGTGDWAFIRIIVRNTTTSTNSPTKEGFIPSRLIGAPCSRKSSTSSSRQSSSVRRGSTSV Hydra_magnipapillata ------------------------------------------------------------ Nematostella_vectensis ------------------------------------------------------------ Trichoplax_adhaerens --------------------------------------------------------LSGI Trio_Human CELTVVIHDFTACNSNELTIRRGQTVEVLE----------RPHDKPDWCLVRTTDR---- Trad_Human CELTVVLQDFSAGHSSELTIQVGQTVELLE----------RPSERPGWCLVRTTER---- Saccoglossus_kowalevskii ------------------------------------------------------------ Branchiostoma_floridae EVTLVVEDFEAT-GSQEITVFKGQTVELLD----------RPENKPEFCLVRTLLTEN-- Strongylocentrotus_purpuratus TECGVVVEDFEASSSRELMVSRGQTVEILDQ---------LYEKNRDWYLIRTLAQ---- Harpegnathos_saltator EMTWVVADHLAAPGSKELSVTKGQQVEVLENGST-NTV--SGVCTGEWTLVRLPLTPG-- Apis_mellifera EVTWVIADHSAAPGSKELTVTKGQQVEVLENGS--NI---SGVNTSEWTHVRLLVAPG-- Bombus_terrestris EVTWVIADHSAAPGSKELTVTKGQQVEVLENGS--NI---SGVNTSEWTHVRLLVAPG-- Nasonia_vitripennis EMTWVVADHSAAPGTRELSVTKGQQVEVLENGSGSGLGSNGGSGNGEWTLVRLASTPG-- Tribolium_castaneum LEMTWVVSDFTATCPQELSVTKGQQVEVVE----------VCSSKPDYCLVRMPTRGT-- Drosophila_melanogaster EATWVVADYIATSGSNELSVSKGQQVEIVEP---------PTAGEPDFCLVRLNPQH--- Drosophila_willistoni EATWVVADYTASSGSNELSVSKGQQVEIIEL---------PTASEPHFCLVRLNLQH--- Drosophila_grimshawi EATWVVADYIASAGSNELSVSKGQQVEIIEL---------PTASEPDFCLVRLNPQH--- Anopheles_gambiae EMTWVIADHTAAPGTSELSVSKGQQVEIVDM---------NCSGAPDYCLVRLSINAS-- Anopheles_aegypti ------------------------------------------------------------ Culex_quinquefasciatus GLGWIFG----------------------------------------------------- Pediculus_humanus EMTWVIGDHVAAPGSQELTVHKGQQVEVLD----------VNVSSPDWCLVRMSTSGS-- Ixodes_scapularis ------------------------------------------------------------ Caenorhabditis_elegans SEVWIVTADFDGQVEGHLTVHKGDRVEIVE-----------DQATDCAEYVQVVLCDQ-- Caenorhabditis_briggsae ------------------------------------------------------------ Loa_loa ------------------------------------------------------------ Brugia_malayi ------------------------------------------------------------ Ascaris_suum SESCIAVDDFEAIENDQLSVTKGQRLEVVE----------LCQDTREWVLVSYIGEGG-- Schistosoma_mansoni RKWLPSGVGTGRRSTGGSTNSAGVTPGKRGSKVDISQSQV-LNTPYPVATSTTNGQTNNE Hydra_magnipapillata --IFIVTDDYIAKSSHEICLTRGQHVEILS----------RPPGSRSWRVRTYDEVLG-- Nematostella_vectensis --IWLVAENYRAATEEEISLRKGQFVEVLVKS----------HGSTRWRVRILNSDG--- Trichoplax_adhaerens G----SEKDYSSGEELLLGSIAEPQERKTKWRK----KSTKSRFSQQHSSDDS------- Trio_Human ---SPAAEGLVPCGSLCIAHSRSSMEMEGIFNHKDSLSVSSNDASPPASVA--------- Trad_Human ---SPPLEGLVPSSALCISHSRSSVEMDCFFPLVKDAYSHSSSENGGKSESVANL----- Saccoglossus_kowalevskii ------------------------------------------------------------ Branchiostoma_floridae ---SPSAEGLVPNNIL---AVAHSRSSLSMD----DALTVAPCPAAESGHNPAT------ Strongylocentrotus_purpuratus -DNATPIEGLVPASCIRVPSQRYSSSSLELE----GGTGGGGGGGLGPINNNDLQGGPKR Harpegnathos_saltator -QAEPPAEGLVPTSALKQPPTASCKTSPSRKASTQQQQQQQQQQSHHHQSHHHPYHHQQI Apis_mellifera -QVDPPPEGLVPTSALKQPPPVSSKTSPSRK----VPGQQQQQQQQQQQQQQQQQQQQQQ Bombus_terrestris -QVDPPPEGLVPTSALKQPPPVSSKTSPSRK----VPGQQQQQQQQQQQQQQQQQQQSH- Nasonia_vitripennis -QSEPPAEGLVPTSALKQPPTATCKTSPSRKPPLAAAQAQTPLQQASLNADDEII----- Tribolium_castaneum DHDSSVPEGLVPLAVLKQPPAPRSSPSRRAPLDHELVTATTYGICLFKFNSTRCLGCCVI Drosophila_melanogaster -DDAAVQEGLVPVSVLKPPPGSHKHGSGTAA----NAASAAG---------SQKSDM-QD Drosophila_willistoni -DDAAVQEGLVPVAVLKPPPGSHKPASSSSS----AVGAAAQ---------KANDSMQQD Drosophila_grimshawi -DDSAVQEGLVPVAVLKPPPGAHKQGSSSAS----TGGAAAGATTATTPSQKPNDSM-QD Anopheles_gambiae ----DSQEGLVPVTVLKPLPSSHSKLNNKQR----DTDTLGEVPQ--------------- Anopheles_aegypti ------------------------------------------------------------ Culex_quinquefasciatus ------------------------------------------------------------ Pediculus_humanus --VDSPPEGLVPLSILKQPPGLRTSPCRKNSNDLETEPGTSDGT---------------- Ixodes_scapularis ------------------------------------------------------------ Caenorhabditis_elegans ----PTKHGLVPASIIAPPESGSVPDRPDDSNASGSTVSKRKSLRRIFANS--------- Caenorhabditis_briggsae ------------------------------------------------------------ Loa_loa ------------------------------------------------------------ Brugia_malayi ------------------------------------------------------------ Ascaris_suum ----EQRQGLVPASVLSSTEPSDGVSASCSTDRPLVGPSSPSVSQNIVKRK--------- Schistosoma_mansoni QQPKTLELGGLLLDNVSEESVDVELPPPMNEIQ---PPLRPNVTELLDTKTVKEVQNNGT Hydra_magnipapillata ----QDSEGMVPYSILRKVDESPMRGIRNSVETLNSQSSEDSYQQDSPKGSIQS------ Nematostella_vectensis ---TVPAEGWVPYATLRRPEDNRKKRHSDISHSSSEAASCDVSKRLSNLFSIPDS----- Trichoplax_adhaerens IPRSYGLKRSSTLPEFIKDPDVDTESTSSSFEINQYYYTEPSKGKFNRSNSTKAI----- Trio_Human ------------------------------------------------------------ Trad_Human ------------------------------------------------------------ Saccoglossus_kowalevskii ------------------------------------------------------------ Branchiostoma_floridae ------------------------------------------------------------ Strongylocentrotus_purpuratus KGSINPNQENAWNVQSPTKITQSTHRFEVWRCQYDNAKLEGGTGGGG------------- Harpegnathos_saltator NQAIVQAQQQTAVQTSSGAVNALQATSTAVSTAAPVTQTTSLTALSSAVLSPTLSEDAEA Apis_mellifera LHYQQQSSSQVQTVASSGGFATASS-AAGVAGSSSTVATS---VTPVLPIQNVP---VLP Bombus_terrestris -YHQQQSTSQIQTAASSGGITTVSSGATGIPGSSSSVVGTGIVASGGLSAQNVPPSSILP Nasonia_vitripennis ------------------------------------------------------------ Tribolium_castaneum RVFFEKISSKCRVKVAQNLTTDKLTRINAT------------------------------ Drosophila_melanogaster ------------------------------------------------------------ Drosophila_willistoni ------------------------------------------------------------ Drosophila_grimshawi ------------------------------------------------------------ Anopheles_gambiae ------------------------------------------------------------ Anopheles_aegypti ------------------------------------------------------------ Culex_quinquefasciatus ------------------------------------------------------------ Pediculus_humanus ------------------------------------------------------------ Ixodes_scapularis ------------------------------------------------------------ Caenorhabditis_elegans ------------------------------------------------------------ Caenorhabditis_briggsae ------------------------------------------------------------ Loa_loa ------------------------------------------------------------ Brugia_malayi ------------------------------------------------------------ Ascaris_suum ------------------------------------------------------------ Schistosoma_mansoni DGAGDSFLLDDVAITNNHCRSDIAQISNNSLSNNSENEIQHEKLIKTVHRLATTIAEVAG Hydra_magnipapillata ------------------------------------------------------------ Nematostella_vectensis ------------------------------------------------------------ Trichoplax_adhaerens ------------------------------------------------------------ Trio_Human ----------------SLQPHMIGAQSSPGPKRPGNTLRKWLTSPVRRLSSGKADGHVKK Trad_Human ----------------QAQPSLNSIHSSPGPKRSTNTLKKWLTSPVRRLNSGKADGNIKK Saccoglossus_kowalevskii ------------------------------------------------------------ Branchiostoma_floridae ----------------SSYSLPNTVHTSPHAKRRAGSFRKWLTSPVRKLSSAGSTRVDKA Strongylocentrotus_purpuratus ----------------GGGLGPINNNDLQGGPKRKGSIKKWLTSPIRKPSGKGAERIETP Harpegnathos_saltator A---------------GSDGSGSASTNSPGNKRRGFSGRKWLPPPLRKLSQGKVEKTNTT Apis_mellifera DETENV----------ANDGSTPANTNSPGNKRRGFSGRKWLPPPLRKLSQGKVEKSPPT Bombus_terrestris DETENIIVGTAAAAAAANDGSGAANTNSPGNKRRGFSGRKWLPPPLRKLSQGKVEKSPPT Nasonia_vitripennis ----------------GSDGCGSANTSSPGNKRRGFSGRKWLPPPLRKLSQSKVDKSAAT Tribolium_castaneum ----------------SNDTTGTVNTSSPVNKRRGFSGRKWLPPPLRKLSQGKVDKTQST Drosophila_melanogaster ----------------QSNRS-KADALSSSTKRRGFSGRNWLPL----MNRKGTDKPP-S Drosophila_willistoni ----------------QGNRSGKADALSSSTKRRGFSGRKWLPPPLRKLSQSKVEKPP-N Drosophila_grimshawi ----------------QGNRS-KADALSSSTKRRGFSGRKWLPQPLRKLSQSKVEKSPNN Anopheles_gambiae ----------------ESDCILPNQHTSPVNKRKGFSGKKWLPTQFRKLSHGKSDKLPPV Anopheles_aegypti ------------------------------------------------------------ Culex_quinquefasciatus ------------------------------------------------------------ Pediculus_humanus ----------------GTTSAGHAIASSPVNKRRVFSGRKWLPPPLRKLSQGKVEKNNTQ Ixodes_scapularis ------------------------------------------------------------ Caenorhabditis_elegans ----------------SKERAAAANSSSSNNNSPATRQSTSTSSPVTANGHTTESSTSAP Caenorhabditis_briggsae ------------------------------------------------------------ Loa_loa ------------------------------------------------------------ Brugia_malayi ------------------------------------------------------------ Ascaris_suum ----------------SIRRFFNNQSSSSPSRPQSVSGGVRRSSNAPQNRLSAADPLQPT Schistosoma_mansoni DGQTQLGD-VPQLIGLPGGASLSGIGNLRLHGGLNVATKLVAGSSKSS-IPIIHSTTGSP Hydra_magnipapillata ----------------ISSDSKKRKSTKSEFMSGTLKMRTWARSSGRKLNANIRSSQPST Nematostella_vectensis -----------------VSISSTESPTTSWYSTPPPNGNGGSSPPVRRRSKSNTHRNSMK Trichoplax_adhaerens -------------------------------LRSTNKFAKSLIKKSSSNKNTKAGISPPF Trio_Human L----------------------------------------------------------- Trad_Human Q--------------------------------KKVRDGRKSFDLGSPKPGDE-TTPQGD Saccoglossus_kowalevskii ---------------------------------------------------------MET Branchiostoma_floridae IPEPPPPPPPP------------------PLPPGRLGKKPLGAKQKGKNLLSGHND---- Strongylocentrotus_purpuratus N----------------------------RTANSGSGRGRRLDQKGQEPFIEEAASQQEG Harpegnathos_saltator MPASSSPLTGSSLKKSSSDKRFKLPSGVEHNRPGKVAYEAEAQEGE-------------- Apis_mellifera T----TATATSMT-------SIVPPSGDR--LKKNVSEKRFKLPTGAEQSRPSRTASISI Bombus_terrestris T----TPTATATTATTSTAISIVQTSCERSSLKKNVSEKRFRLPSGAEQSRPLRSASVSI Nasonia_vitripennis SDRPPPPPPPPLPSSTKKSSGLDKLFKLPSSGSSDKSQAAAAAAAA-------------- Tribolium_castaneum A-------------------------LERPPLKKTGSDKRIKVPSE-------------- Drosophila_melanogaster S----------------------------KPLVKKPSEKNLRTPQKHAEELAEQQN---- Drosophila_willistoni D----------------------------KSLIKKPSEKNLRTPQKHVEEQQQQQQ---- Drosophila_grimshawi D----------------------------KALMKKPSEKNLRLTQKHTEELAEQ------ Anopheles_gambiae E---------------------------KTLISKKGSDKKVKPNQQEKPPEEQESSAA-- Anopheles_aegypti ------------------------------------------------------------ Culex_quinquefasciatus ------------------------------------------------------------ Pediculus_humanus D----------------------------------------------------------- Ixodes_scapularis ------------------------------------------------------------ Caenorhabditis_elegans I----------------------------------------------------------- Caenorhabditis_briggsae ------------------------------------------------------------ Loa_loa ------------------------------------------------------------ Brugia_malayi ------------------------------------------------------------ Ascaris_suum S----------------------------------------------------------- Schistosoma_mansoni DLSTNSTSSSHFLGQDEELLLDILEEGVELHFVTRHLFLYDHALIIADAAMELTTT---- Hydra_magnipapillata ------------------------------------------------------------ Nematostella_vectensis KMMN-------------------------------------------------------- Trichoplax_adhaerens DESVTHQNLLRKHSAP------------------------------------EVAGFVKL Trio_Human ----------AHKHKKSREVRKSADAGSQKDSDDSAATPQDETVEERGRNEGLSSGTLSK Trad_Human SADE-------------------------------------------------------- Saccoglossus_kowalevskii WSVLPLVTTLGHTFILAQLLGAANNDTSAARDEPPLAQPEDLAEEERV--SSSREDLSPE Branchiostoma_floridae ------------------------------VGRATPPPLAQEEDLLEDERISSARGSSEN Strongylocentrotus_purpuratus GAREELAGIDNVVHEASGETVDLKPAVRVSDLPIDEEEGEAEAVPLPPPMELQNHSSLIG Harpegnathos_saltator -----------------------------------EADKEEEGEEQQEIEVEVDVDITES Apis_mellifera SALTTATASMRVSA--SEADLDTELQPGIEG-EEDEGETEQS-EPELEED-VPEPDNTEA Bombus_terrestris SALTTATASMRVSTSVSEADLDTELEPGLEGAEEEEGETEQS-EPELEEDTMPEPDDTEA Nasonia_vitripennis ------------AAAAAASSSSVASTTTPNATTTTASRQSSGEEEVVGASGAEDNEDARS Tribolium_castaneum --------------------------------------MGNKPSVSEGEDDEDRLPLSIK Drosophila_melanogaster ---------------------------------QQPG----ASPATVLPSSQF--P---S Drosophila_willistoni ---------------------------------LVEGGGATGTPVNLSSTPQYTTP---Q Drosophila_grimshawi ----------------------------------TPG--ASGSVGQLPPHPQF--PNVSS Anopheles_gambiae ------------------------------------------------------------ Anopheles_aegypti ------------------------------------------------------------ Culex_quinquefasciatus ------------------------------------------------------------ Pediculus_humanus -------------------------------RPQLKKTPSDKRFRLPSIEMGNKQSSTTA Ixodes_scapularis ------------------------------------------------------------ Caenorhabditis_elegans ------------------------------------GVLSSGEPTSSNSIPSSSTPTHTV Caenorhabditis_briggsae ------------------------------------------------------------ Loa_loa ---------------------------------------------------K-------- Brugia_malayi ------------------------------------------------------------ Ascaris_suum ---------PSSSESHNETPSARETNYGISGGARSVLSSCIDQSSSVAQSSCPLSG---- Schistosoma_mansoni -TTLPENSSSLNGNKSLNDNSDNHKPKLQCRFRHALPINQISVLEDVGVGGSRPTGDQLL Hydra_magnipapillata ------------------------------------------PTRQKNISGGGTNKLQVD Nematostella_vectensis --------------------------------------------KPGQAPSPTNTPARSK Trichoplax_adhaerens PSSRSQKDFDTLESEFWAEDMEKVLTESKKFSTPPQN----------------------- Trio_Human SSSSGMQSCGEEEGEEGADAVPLPPPMAIQQ-HSLLQPDSQDDKASSRLLVRPTSSETPS Trad_Human ----KSKKGWGEDEPDEESHTPLPPPMKIFD-NDPTQDEMSSSLLAARQASTEVPT---- Saccoglossus_kowalevskii IAAKKLPEQNGEEEDGYETETPLPPPMEIQS-LQFTQVLTQEEAQ--------------- Branchiostoma_floridae MAAARSVEAAGEEEEPESEAMPLPPPMEIVQ--HSFSRPNSQEDLSASKMSLTASMRS-- Strongylocentrotus_purpuratus PPSGAAHDKREEGEKETEKGGEECGDGKTDE--EGVTMTTGQPATIKEEDENEKEMVHKK Harpegnathos_saltator EDTATVSLQEQNGGEDADDDLELPPPMKPIT--EPILVTTANGPSGSTIPNELSGKRTAE Apis_mellifera L----TYSEQNGADDVEDEL-ELPPPMKPIT--EPILVGTANGASGSAITTEGCGKSRTS Bombus_terrestris L----TYSEQNGADDAEDEL-ELPPPMKPIT--EPILVATANGSSESAIATESCGKSRTS Nasonia_vitripennis VGTGASHSEQNGAEDAEDEQPELPPPMKPIT--EPILVAGAAAAPASSDELPGKLTTEGS Tribolium_castaneum NTKSLASELTNGGGEDADEEVELPPPMKPIQ--EPIVVTSTPPGVPDIEENPCKRVSSLT Drosophila_melanogaster STQHPGGAGAGDYEPDEEVGLELPPPMKPIQ--EPHLIANGPPAFAKDAKESSGNM---- Drosophila_willistoni QQQQQQTQHQADFEPDEEAGLEMPPPMKPIQ--EPHLIANGPPAYTKDLKEPA-NL---- Drosophila_grimshawi SSTNQQLQQQHDFEPEEEAGLELPPPMKPIQ--EPHLIANGPPTFPKDLKEGSANM---- Anopheles_gambiae -----ASAAQLEPEDEEATAIELPPPMKPIQ--DTASALSGASVVPSSAEDAAAGSTNKI Anopheles_aegypti ------------------------------------------------------------ Culex_quinquefasciatus ------------------------------------------------------------ Pediculus_humanus EEELESSNRLENGEEGEEDAVELPPPMKPIQ--EPLLVPTEDSQGERISELSLTHL---- Ixodes_scapularis ------------------------------------------------------------ Caenorhabditis_elegans PSSVPATVIPIVVAEDEKAEDCLPPPME-------------------------------- Caenorhabditis_briggsae ------------------------------------------------------------ Loa_loa ------------------------------------------------------------ Brugia_malayi ------------------------------------------------------------ Ascaris_suum TPTVVDSALDPATSLSDQPDFDLPPPMSDLS----------------------------- Schistosoma_mansoni W-FCLSERTRYLGSPF-ESSVAAASPPQSHLCYIIAPKSPD-SRIRWLSELTSMILEARR Hydra_magnipapillata PSSNNLYVSALLGAPKKEIDLLIRPSDGT----YATLGRSASRNTERVKFLSA------- Nematostella_vectensis KISGGGSKKLQQMLGASESDIDLIPEEDVVETESSDSKPHDAIKIFPVSDDED------- Trichoplax_adhaerens --------------------------------------------------------DIQT Trio_Human AAELVSAIEELVKSK------------------MALEDRPSSLLVDQGDSSSPSFNPSDN Trad_Human ---------------------------------AADLVNAIEKLVKNKLSLEGSSYRGSL Saccoglossus_kowalevskii -------RQQQEEDL------------------EASQEADEVDAEANLLNEEVDSEEEEK Branchiostoma_floridae ----------LNVAGSTTDLVSEIENIAKQRLDEPGLPDEAEGGEGGAPQNQA------- Strongylocentrotus_purpuratus KRRQQNQNRYQSLNQNLNQNQSLQMRREHKRRKRQGRRQAGRDGGRQGGRQAGREAGRQG Harpegnathos_saltator RST-------KILDGASTADLSEIEQIVKERMEQHTENQERHSLMRTPNGKSLSSEEDYC Apis_mellifera ERST------KILDGATTVDLAEIEQIVKERMEQHTENQERQSLMRTPSGKNSSIGGSGD Bombus_terrestris ERSA------KILDGATTADLAEIEQIVKERMEQHTENQERQSLMRTPSGKSSNVGIGGD Nasonia_vitripennis I---------KPLDGATSADIAEIEQIVKERMEQHTENRERNSSTSSSVGTQARTPVKSS Tribolium_castaneum L---------KSLEGATSADLAEIEQIVKERMEQHSENQERNSGLRDTKSADAISDCGDQ Drosophila_melanogaster ----------ASPGKMDGNPLSEIEEIVKTTTEQHESNSRVDGGGGV-----ENASTNGH Drosophila_willistoni ----------ASAGKFD-----EIEQIVRERTEQHESNSRVDGSGGRVGAGGENANTNGH Drosophila_grimshawi ----------ASTGKIDSNPLSEIEQIVQKSREQHESNSRPDGSAPSEAGGEDNAATNGC Anopheles_gambiae TKAMSLKSLEEPVGAQPPADLAEIEQFVKAKVESLKYLDNDGGGGGSSSSSAAAALAMGL Anopheles_aegypti ------------------------------------------------------------ Culex_quinquefasciatus ------------------------------------------------------------ Pediculus_humanus ------------------EGAAEIEQIVKERMEQHTENREKNNTLNRDGKSVGDVTATGA Ixodes_scapularis ------------------------------------------------------------ Caenorhabditis_elegans ---------------------------------NITINNSIDEKDMNEDSVAASDAVEPE Caenorhabditis_briggsae ------------------------------------------------------------ Loa_loa ------------------------------------------------------------ Brugia_malayi ------------------------------------------------------------ Ascaris_suum -------------------------------------SAVADAAASHSTTMQNPQQAQES Schistosoma_mansoni LSQAYLMNNVSFGSGDLNSGCSTTTTTTTGQIKLPGATLYPSGVLFD-TGSLELPKSGRY Hydra_magnipapillata ---------------------------------LDHDDPGFQEGDYDSEDSVNDICTNLN Nematostella_vectensis --------------------------------EEDLDEMSVEGVRGEAEGEEQPVDDEED Trichoplax_adhaerens SLLTSSSNYYESSMDSHAIENNYTKQMKSDVQAVRNRSLDKNILPISPVTIKAEGYSNVD Trio_Human SLLSSSSPIDE------------------------------------------------- Trad_Human KDPAGCLNEGM----------------------------------------APPTPPKNP Saccoglossus_kowalevskii QEELEKQETEATEEDAE----NEEEARGPVTEAEEIALAEK------------------- Branchiostoma_floridae -------------------------------------------------------EGRGD Strongylocentrotus_purpuratus GRQVGREGGREGGRQGGRQAGREADRQAGREGGRQGGRQAGREAGREGRREADMLGGRRQ Harpegnathos_saltator NTTNPAVLEES------------------------------------------------- Apis_mellifera NDYDKDAVSSA-TIATTTIASSTTIMTTAATATVATGI-TMTTTTTKMGTTSSPAHGNSE Bombus_terrestris DDYDEGTLSTAITIAATMIPAPTTVTSTTTMTTAATMVTTMATTTTTTTTTSSPVHGTPE Nasonia_vitripennis SATAGGSSDSP---------------------------TLTGSLSTQNASTESEEPPTTG Tribolium_castaneum PNTHRELSARC-------------------------SSNEATASAFSGDESDKPSEDNVD Drosophila_melanogaster GR-SH--DNND--------------------------------------------ESHTA Drosophila_willistoni GR-SHAGDNNE--------------------------------------------ENHTS Drosophila_grimshawi AELGFVQGNND--------------------------------------------KNKTD Anopheles_gambiae MVGDGSSSSGT--------------------MALNGGHTIAKPAISPQFSENEAADDTLT Anopheles_aegypti ------------------------------------------------------------ Culex_quinquefasciatus ------------------------------------------------------------ Pediculus_humanus GTTTPTTGSSE-----------------------------TNNSRNSVVDITTSSSSTTT Ixodes_scapularis ------------------------------------------------------------ Caenorhabditis_elegans VALPA-----------------------------------------------------KV Caenorhabditis_briggsae ------------------------------------------------------------ Loa_loa ------------------------------------------------------------ Brugia_malayi ------------------------------------------------------------ Ascaris_suum TEVVSESENGA---------------------------------------------ADKG Schistosoma_mansoni KIVNQDSLKNSTRYHANVSVDQLSSGIGNLTMNQSMLPTCSTSSLQQSSTLLQSTNSHIV Hydra_magnipapillata GSI--------------------------------------------------------- Nematostella_vectensis ATGPGLVPEDP------------------------------------------------- Trichoplax_adhaerens GQKGK------------------------------------------------------- Trio_Human MEERKSSSLKRRHYVLQELVETERDYVRDLGYVVEGYMALMKE--DG---VPDDMK-GKD Trad_Human EEEQKAKALRGRMFVLNELVQTEKDYVKDLGIVVEGFMKRIEEKG-----VPEDMR-GKD Saccoglossus_kowalevskii ---KKKDAEQKRQFILQELVQTEIDYVADLGKLVEGYMKLMKDE-----PLPSGLEDGRD Branchiostoma_floridae TLERQASALKKRRFILQELLETERDYVKDLGSVMEGYVATMKE-QG----IPEDME-GKD Strongylocentrotus_purpuratus GGGGREEGRARRKFVLEEMVVTESDYVADLAKVVIGYREDMKK-EETE--LPSEMESGKV Harpegnathos_saltator --DPESSAIAKRQFVIRELVDTEKDYVNDLKQIVEGYMALVRN-PDCEIPLPENLRGGKD Apis_mellifera EYDLESAVLVKRQFVIRELVETEKDYVNDLKQIVEGYMALMRD-SESQVPLPDDLRGGKD Bombus_terrestris ECDVESAVLAKRQFVIRELVETEKDYVNDLKQIVEGYMSLMRD-PESEVPLPDDLRGGKD Nasonia_vitripennis SDDPVASALTKRQFVIRELVETERDYVNDLRQIVEGYMALMRD-PNTDIPLPDDLKGGKD Tribolium_castaneum SAKKTESLLRKRQFVLQELVDTEEAYVRDLSLIVDGYMATMKD-PECEIPMPEDLRDGKD Drosophila_melanogaster VSD-KAAALKKRQCVFAELMSTEEAYVQDLHEIVNGYMTEINN-TNSDIPMPEDLKGGKM Drosophila_willistoni AMDSKEAAQRKRQHVLKELVTTEETYVSDLNEIVNGYMAEVYN-SSSDIPMPDDLKGGKI Drosophila_grimshawi TSDSEASALNRRQLALNELVITEESYVQDLQMIVNGYMKEIYN---KEIPRPPGLQDGKM Anopheles_gambiae EEQCIEDILRKRNYALRELLTTEEAYVNDLSQIVNGYIAEIRN-PASTVLIPDDLKGGKE Anopheles_aegypti ------------------------------------------------------------ Culex_quinquefasciatus ------------------------------------------------------------ Pediculus_humanus NNNNPEDAMLKRDYVIRELVDTEKDYVRDLGLVVEGYMALMRN-PDCDIPMPEDLKSGKD Ixodes_scapularis ------------------------------------------------------------ Caenorhabditis_elegans EKTPEETARFKRSYVLMELVETEQDYVKDLTSVVEGYIGNLNKMDLPADLVGKDKI---- Caenorhabditis_briggsae ------------------------------------------------------------ Loa_loa ------------------------------------------------------------ Brugia_malayi ------------------------------------------------------------ Ascaris_suum EKSAEEMARIKRQYVLMELVETERDYVKDLSSVVDGYMANLQTMDLPEDLVGKDKI---- Schistosoma_mansoni ------------------------------------------------------------ Hydra_magnipapillata KEDSDERASTKRNKILTEMIETEKEYINVLEIANLTILPSMNK--RTD--VP-DDLRGKE Nematostella_vectensis ----EAVALKKRTFVLRELIQTEQDYVTSLGEVVDGYIAEFSK------PDLPEELKGKE Trichoplax_adhaerens ------RLLQEEIQIIQELIKCEELYVRDLEYMINGYMTLIEDGNNYDWQVPETLKQNKQ Trio_Human KIVFGNIHQIYDWHRDFFLGELEKCLEDPEKLGSLFVKHERRLH-MYIAYCQNKPKSEHI Trad_Human KIVFGNIHQIYDWHKDFFLAELEKCIQEQDRLAQLFIKHERKLH-IYVWYCQNKPRSEYI Saccoglossus_kowalevskii KMVFGNIRQIYDWHKETFCKEIESCQENPEKLPAIFLRYERRL-QMYVIYCQNKAKSEYI Branchiostoma_floridae KIVFGNIHQIYEWHRDTFSGELEKCADSPDRVANLFLRYERRLH-MYVVYCQNKPKSEHI Strongylocentrotus_purpuratus KIVFGNIHQIYEWHRDTFSKEIAKVKEEPEKLGPLFKRYERRLR-MYVVYCQNKPKSEFI Harpegnathos_saltator KMVFGNIEAIYEWHRDFFLKALERCLERPEELGPLFKRYERKLH-MYVVYCQNKPVSEYI Apis_mellifera KMVFGNIEAIYEWHRDFFLKALERCLERPEELGPLFKRYERKLH-MYVVYCQNKPVSEYI Bombus_terrestris KMVFGNIEAIYEWHRDFFLKALERCLERPEELGPLFKRYERKLH-MYVVYCQNKPVSEYI Nasonia_vitripennis KMVFGNIEAMYEWHRDCFLKSLEHCLERPEELGPLFKRYERKLH-MYVVYCQNKPVSEYI Tribolium_castaneum KMVFGNIEAIYDWHKDIFLKSLKKAIENPTELAQLFRRYERKLH-MYVVYCKNKPVSEYI Drosophila_melanogaster KLVFNNIKDIYEWHRDFFLRALRNCQKSPADLGPLIKRSATKFA-LYYTYCSNKPLSEYI Drosophila_willistoni RLVFNNIKDIHDWHKESFVRALRHCQKTPSELGPLIKRSTPKFA-MYYYYCSNKPLSEFI Drosophila_grimshawi DLVFNNIKEIHEWHRDKFLRALRHCQRSPADLGPLIESSAKKFT-MYYYFCSNKPLSEYI Anopheles_gambiae RMVFGNIEAIYEWHRDHFLKALQKCLQNPYELGPLIKRSERKLH-MYVVYCQNKPVSEHI Anopheles_aegypti ------------------------------------------------------------ Culex_quinquefasciatus ------------------------------------------------------------ Pediculus_humanus KMVFGNIEAIYEWHKSRFLVSLEECIEHPEKLGPLFKKYERKLH-MYVVYCQNKPVSEYI Ixodes_scapularis ------------------------------------------------------------ Caenorhabditis_elegans --IFANIVNILEFHKTNFLKEIEKCSENYEAAGAAFVKYERRLHTLYVTYCQNKPKSDYL Caenorhabditis_briggsae ------------------------------------------------------------ Loa_loa ------------------------------------------------------------ Brugia_malayi ------------------------------------------------------------ Ascaris_suum --IFANIAQILDFHKTLFLKEIEKCLDDYEAAGNAFVKYERRLHTYYVKYCQNKPKSDYL Schistosoma_mansoni ------------------------------------------------------------ Hydra_magnipapillata KVIFGNIPSLLYFHK-MFVKEFEPCNLAPENVASVFLKFEKEFE-MYIQYCANKPRSAAL Nematostella_vectensis RMVFGNIKQIYEWHKTVFCRELEKCEDAPEKLASVFLKAERRLQ-MYVIYCQNKPKSTAL Trichoplax_adhaerens S-IFRNIEKIRNWHKNVFCKSLKSCLERPEKLGSVFLKFDSQRL-NYVEYCFNIPKSQIL Trio_Human VSEYIDTFFED-LKQRLGHRLQLTDLLIKPVQRIMKYQLLLKDFLKYSKKASL--DTSEL Trad_Human VAEYDAYFEEV--KQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGL--ECSDI Saccoglossus_kowalevskii VSEFENFFSEC--KAKLGHKLAISDLLIKPVQRIMKYQLLIKDFLKQSKKMGI--DCKEL Branchiostoma_floridae VSEYIDTYFEE-MRTKLGHKLSLQDLLIKPVQRIMKYQLLLKDLLKHTQKAGL--DSSEL Strongylocentrotus_purpuratus VNEF-ETFFEE-MRVKLGHKLSLSDLLIKPVQRIMKYQLLLKDILKQSQRAGM--DTVEL Harpegnathos_saltator VSEYIDTYFEE-LRQKLGHRLQLCDLLIKPVQRITKYQLLLREALRLTERTQRLSEIEGL Apis_mellifera VSEYIDTYFED-LRQKLGHRLQLCDLLIKPVQRITKYQLLLREALRLTERTQRISEIEGL Bombus_terrestris VSEYIDTYFED-LRQKLGHRLQLCDLLIKPVQRITKYQLLLREALRLTERTQRMSEIEGL Nasonia_vitripennis VSEYIDTYFEE-LRQKLGHRLQLCDLLIKPVQRITKYQLLLREALRLTQRTHRQSEIEGL Tribolium_castaneum VSEYLESYFEE-LRVKLGHKLQLCDLLIKPVQRIMKYQLMLKDILKYTERAGLTAEAEPL Drosophila_melanogaster VSAHYQ-YFDS-IRQKLGHRLDLSNLIIKPVQRITKYELLIKEIIKATEGAGLYKEVPML Drosophila_willistoni VSAHYD-YFDC-IRQKLGHRMDLRNLIIKPVQRITKYELLIKDLIKATEGAGLHKEVAIL Drosophila_grimshawi VNEYYD-YFDQ-IRQKLGHRHDLSALIITPVQRITKYGLLINEILKQTERAGLHNEVATL Anopheles_gambiae VQEHM-SYFDE-LRLKLKYKLCLGDMLIKPVQRIMKYELLLKDILKHTLRAGLTEEVPGL Anopheles_aegypti ------------------------------------------------------------ Culex_quinquefasciatus ------------------------------------------------------------ Pediculus_humanus VSEYIDTYFEE-LRQKLGHKLTLGDLLIKPVQRIMKYQLLLRDIAKYTQRADLKSEMEDL Ixodes_scapularis ------------------------------------------------------------ Caenorhabditis_elegans LAQDDFEAFFADTKAKLGHKVALCDLLIKPVQRIMKYQLLLKDILKFTERAKD--KTDTL Caenorhabditis_briggsae ------------------------------------------------------------ Loa_loa ------------------------------------------------------------ Brugia_malayi ------------------------------------------------------------ Ascaris_suum VGQEDFEQFFAETKQKLGHKVALCDLLIKPVQRIMKYQLLLKDIVKYTERAGDRLDV--L Schistosoma_mansoni ------------------------------------------------------------ Hydra_magnipapillata VSDYLQSFFND--ITEKENTIGLEDLLMRPVERIMKYHSMLKEFTKYSWRSGK--DTIQL Nematostella_vectensis VHEFKETYFTD-MKDRLGYRLSIEDYLIKPVQRVMKYQLLLKDFVKYTERAGL--DIIEL Trichoplax_adhaerens VNEYNDFFEKC--EKMLNLPSSLQDYVIRPVEQLRLYQSWLNRLLTY---VGASLNAIDV Trio_Human ERAVEVMCIVPRRCNDMMNVGR-LQGFDGKIVAQGKLLLQDTFLVTDQDAGL------LP Trad_Human EKAVELMCLVPKRCNDMMNLGR-LQGFEGTLTAQGKLLQQDTFYVIELDAGM------QS Saccoglossus_kowalevskii EKAYDIMCVVPKRANDMMALGR-LQGWDGKITAQGKLLRQDTLLVSEGISSL-----QHF Branchiostoma_floridae EAAVNVMCVVPKRCNDMMNIGR-LQGFDGNINAQGKLLLHDPMIVSDNSSLL------QW Strongylocentrotus_purpuratus EQAVNIMKVVPKKANDMMAISR-LQGWDGKINAQGELLMQDLLMVAVADEG-------TQ Harpegnathos_saltator RAAAHVMRVIPKAANDMMDVGR-LQGFDGKITAQGKLLLHGPLMVSELSNV-------ST Apis_mellifera RAAVHVMRIIPKAANDMMDVAR-LQGFDGKITAQGKLLLHGPLLVSEFSSNL------PS Bombus_terrestris TAAVHVMRIIPKAANDMMDVAR-LQGFDGKITAQGKLLLHGPLLVSEFSSNL------PS Nasonia_vitripennis TAAAHVMHVIPKAANDMMDVGR-LQGFDGKITAQGKLLLHGPLMVAELSSL-------PS Tribolium_castaneum RTAYQIMVDLPKAANDMMDVGR-LQGFDGKITAQGKLLLHGPLTCTDVQGTV------VG Drosophila_melanogaster QEAYQQMKVVVKTVNDMMVVLRSLQDFDGEITAQGSLLMQGPMNCVVD-A--------AQ Drosophila_willistoni QEAYQQMKVVVNTVNDMMMILRSLQDFDGEITAQGNLLMQGPLNCVTE-A--------A- Drosophila_grimshawi IAAYEQMNDVVKKVDDMMMVLRGLQDFDGEITAQGNLLLHGTLTCAIDGA--------GQ Anopheles_gambiae KEAMHIMQVVPKAANDMMDVGR-LQKFEGKITTQGKLLLHGPLYCVEGASSSDKNSYNSQ Anopheles_aegypti ------------------------------------------------------------ Culex_quinquefasciatus ------------------------------------------------------------ Pediculus_humanus RIALQVMHVVPKSANDMMDVGR-LQGFDGKITAQGKLLLHGLLMCSEVMAAA------GA Ixodes_scapularis ------------------------------------------------------------ Caenorhabditis_elegans KKALQVMHVVPKACDDMMQVGR-LQNFDKSLSAQGKLIHQGTLQISESIAGN------VQ Caenorhabditis_briggsae ------------------------------------------------------------ Loa_loa ------------------------------------------------------------ Brugia_malayi ------------------------------------------------------------ Ascaris_suum KKALQVMHVVPKACDDMMQVGR-LQNFDGNLSAQGKLIFQGTLAISDNAPSQ------PF Schistosoma_mansoni ------------------------------------------------------------ Hydra_magnipapillata VKALHQMYTILKKADDVMNVGM-MSGFPDNLNNQGLLLLQDTVFVADVKA--------QV Nematostella_vectensis KRALHLMHVVPKKANDFLNVGM-LEGYTGKITAQGNLVLQDTLMVMDVNA--------KA Trichoplax_adhaerens KAALHLVESIIVQVEYMSEVGK-LEGYDGNILRLGKLLLHDYLTVYEGKA--------IK Trio_Human RCRERRIFLFEQIVIFSEPL-DKKKGFSMPGFLFKNSIKVSCLCLEENVENDPCKFALTS Trad_Human RTKERRVFLFEQIVIFSELL---RKGSLTPGYMFKRSIKMNYLVLEENVDNDPCKFALMN Saccoglossus_kowalevskii KGKERRMFFFEQMILFSEEL-EKKKGSLYHPGFVYKNSAKVNTLTLQDIKDDPVRFCLKA Branchiostoma_floridae KGKERRVFLFEQIVIFSEPL-DHKKGLSNPGYLYKGCIKVKDMSMMPDVDSDPT--KFSL Strongylocentrotus_purpuratus KYKERRVFMFEQIVIFADQL-EK-KGFSNPGYIFKYSIKVNQLVLDDGDD------PIKF Harpegnathos_saltator RGREWQVFLFEQNIIFSEAV-GKKTLFTNPAYIYKAHIQVNKMSLEESNDDQE---KFVI Apis_mellifera KEKEWQVFLFEQNIIFSEAV-GKKTQFTNPVYIYKAHIQVNKMSLEECY-DDSE--KFII Bombus_terrestris KEKEWQVFLFEQNIIFSEAV-GKKTQFTNPVYIYKAHIQVNKLCLQNPY-DDPE--KFII Nasonia_vitripennis RGREWQVFLFEQNIIFSEAV-GKKTQFTNPAYIYKAHIQVNKMILEDSPDDPE---KFVI Tribolium_castaneum KNKDLQVFLFEQSIILSDVV-GKKTQFTSPQYIYKTHIQVNKMNLHPEED------GFVL Drosophila_melanogaster KHRELQVFLFQQIIIFADIE-KTKNQYASPIFKYRSHIQLNHMQMKEL--GDC---RFQI Drosophila_willistoni KQRELQVFLFQQIIIFADIE-KAKTQFCDPTFKYRSHIQLNHMQIKEL--GDC---RFQI Drosophila_grimshawi KQRDWKVFLFQQIIIFAEIQ-KLKTPYSNPLFKYRTHIQLNHMQLKELKEGEF---SFRI Anopheles_gambiae KPKELHVFLFEQNIIFAEIV-GKKTQFTSPNYIYKAHIQVNKMTLQDLS-DQTNGNRFSL Anopheles_aegypti ------------------------------------------------------------ Culex_quinquefasciatus ------------------------------------------------------------ Pediculus_humanus KAKELQVFLFEQNIIFSEAV-GKKTQFTDPMYIYKAHIQVNKAALDETYCDDPEGVKFVI Ixodes_scapularis ------------------------------------------------------------ Caenorhabditis_elegans KPKDRRIFLFEQSAIIADHI-PPKKEFGNPTYIFKSQFMVNKMVFEPNVPDDPLRFVIKS Caenorhabditis_briggsae ------------------------------------------------------------ Loa_loa ------------------------------------------------------------ Brugia_malayi ------------------------------------------------------------ Ascaris_suum KGKDRRIFLFEQSAIIADCI-LPRKEFGNPTYIFKNQIMVNKMVLEANVPDEPLRFIVRS Schistosoma_mansoni ------------------------------------------------------------ Hydra_magnipapillata LPVEKRVFLFEKQLIFCEPF---ERKPKLLTYIYRHCIKTKNLGLMANYDEDICKLAIWG Nematostella_vectensis KPVKRRVFLFEQLVIFSEPF---ERKTDWTVYIYRHSIKTNHMGHTDGVDDDPCKLAIWT Trichoplax_adhaerens KGKERYVFLFEQAMILADTITNKRRKSETLKYIYKNHIKMNHVRLEEQNTEDLTRWSMWE Trio_Human RTGDVVE---TFILHSSSPS--------------------VRQTWIHEINQILENQRNFL Trad_Human RETSE-----RVVLQAANAD--------------------IQQAWVQDINQVLETQRDFL Saccoglossus_kowalevskii RTKEG---SETFVIQTVSPE--------------------SKQQWVKEIGGLLDKQQNFL Branchiostoma_floridae MSKTRDGEDCYILQTPAAD---------------------VRETWVAEISMLLDRQKDFI Strongylocentrotus_purpuratus TLRAKAKDGLVLNCQASTPV--------------------CKVKWVTEISQVCNQQQNLL Harpegnathos_saltator RSTDPRKPGLGFSCSAAEESGP------------------RRQEWVDTITAILQTQRDFL Apis_mellifera RSTDPRKPGLGFSCSAVEENGP------------------RKQEWVDTITAILQTQRDFL Bombus_terrestris RSTDPRKPGLAFSCSAAEENGP------------------RKQEWVDTITAILQTQRDFL Nasonia_vitripennis RSTDPRKPGLGFVCGCCPASTDESITGSVGGSGSTSGNPLRRQEWVDTITSILQTQRDFL Tribolium_castaneum TSTDPHKPALAICCQAATQE--------------------LQEQWFSTIKNILQTQRDFL Drosophila_melanogaster RSTDPKIPEMTIICQAASQE--------------------NYAGWRDMLNKILQQQNDLI Drosophila_willistoni KSTDPNKPEVVMICQASSKE--------------------RYAEWWGMLEKILEQQNELI Drosophila_grimshawi ESTDPNKPAVTIDCQAGSEK--------------------ANEEWLGKLKMILEQQSDLI Anopheles_gambiae CSIDPQRSSLSYICTAPTPE--------------------LHSEWLNTIHEILKTQNDFL Anopheles_aegypti ------------------------------------------------------------ Culex_quinquefasciatus ------------------------------------------------------------ Pediculus_humanus ISTDRKKSPMGFVCAASSRE--------------------SRNEWVTTIKNMLQTQKDFL Ixodes_scapularis ------------------------------------------------------------ Caenorhabditis_elegans SDPTQPT---SFIANAQSQE--------------------EKDEWNRKMSELLDQQKRLL Caenorhabditis_briggsae ------------------------------------------------------------ Loa_loa ------------------------------------------------------------ Brugia_malayi ------------------------------------------------------------ Ascaris_suum SDPAQPN---AFLAQANTLE--------------------EKEEWIEKINSQLDQQKTLL Schistosoma_mansoni ------------------------------------------------------------ Hydra_magnipapillata KQENGSSE--IYVMTTRSPA--------------------SKKLWHESIRKIIEDQYVCD Nematostella_vectensis SEGTASEIYVLTASSEE-----------------------MKNEWVSALKKLLESQNAFA Trichoplax_adhaerens TGLNNNRDD-CYHFQARSVN--------------------VKNTWLDRIRFIMDNQRSFA Trio_Human NALTSPIEYQRNHSGGGGGGGSGGSGGGGGSGGGGAPSGGSGHSGGPSSCGGAPSTSRSR Trad_Human NALQSPIEYQRKE----------------------------------------------- Saccoglossus_kowalevskii RALQSPIEYQ-RE-------------------------------MEGGASARNSWGLGLE Branchiostoma_floridae RALQSPIEYQRDVLYASNTLRKSFSSPTPVPGSPPSILTQQNCQSNCGSTNSLPDSKSAF Strongylocentrotus_purpuratus KALQSPIAYQKGLEGGASLGLDPFGAPEGKSPGPSPAPSPTSPSADKSTKLRKAVSQSSE Harpegnathos_saltator KAIQSPIAYQKEL----------------------------------------------- Apis_mellifera KAIQSPIAYQKEL----------------------------------------------- Bombus_terrestris KAIQSPIAYQKEL----------------------------------------------- Nasonia_vitripennis KAIQSPIAYQKEL----------------------------------------------- Tribolium_castaneum KAIQSPIAYQKEL----------------------------------------------- Drosophila_melanogaster FMLSNPLSTKNK------------------------------------------------ Drosophila_willistoni NILSNPIQYHR------------------------------------------------- Drosophila_grimshawi TRLVNPLSN--------------------------------------------------- Anopheles_gambiae KALVSPIAYQKELTKDS------------------------------------------- Anopheles_aegypti ------------------------------------------------------------ Culex_quinquefasciatus ------------------------------------------------------------ Pediculus_humanus KAIQSPIAYQKELTKET------------------------------------------- Ixodes_scapularis ------------------------------------------------------------ Caenorhabditis_elegans AALVDPRRYNDMSSGMGDLSLGAPGGDRRGAPSSANRSAASSSKKPAESPKKEGKSKSSL Caenorhabditis_briggsae ------------------------------------------------------------ Loa_loa ------------------------------------------------------------ Brugia_malayi ------------------------------------------------------------ Ascaris_suum AALVDPKRYQNQLAGGVSAISIEDGSSEKKKAMFSRLTGKGKEASASASPVSHNSSASTQ Schistosoma_mansoni ------------------------------------------------------------ Hydra_magnipapillata KVPNISNENFDHS----------------------------------------------- Nematostella_vectensis MALERPIEYQNLME---------------------------------------------- Trichoplax_adhaerens DALSSPIDYQSKQ----------------------------------------------- Trio_Human PSRIPQPVRHHPPVLVSSAASSQAEADKMSGTSTPGPSLPPPGAAPEAGPSAPSRRPPGA Trad_Human ------------------------------------------------------------ Saccoglossus_kowalevskii MSGHARSASQPATNTGSLRKNESGATKKQQKKGSPARAGKSAQSREHRRHQTMPAGITIS Branchiostoma_floridae RKHSVPALMINKENSMMDGSHSLPRMNKSRKISLPTPPLGSPTTPNSPCLSPIPMEFSKE Strongylocentrotus_purpuratus PPTQLQKQHNLFSSLKSRKNQTAPAAISLNELRETKNNAKKNDAKSGTPTHDEKAEKGKD Harpegnathos_saltator ------------------------------------------------------------ Apis_mellifera -----------------------------------------------------------T Bombus_terrestris -----------------------------------------------------------T Nasonia_vitripennis ------------------------------------------------------------ Tribolium_castaneum ------------------------------------------------------------ Drosophila_melanogaster ------------------------------------------------------------ Drosophila_willistoni ------------------------------------------------------------ Drosophila_grimshawi ------------------------------------------------------------ Anopheles_gambiae ------------------------------------------------------------ Anopheles_aegypti ------------------------------------------------------------ Culex_quinquefasciatus ------------------------------------------------------------ Pediculus_humanus ------------------------------------------------------------ Ixodes_scapularis ------------------------------------------------------------ Caenorhabditis_elegans FSFGKKPAKSPTSPPPLDAAAAGKFQKVADDQVNLETDEKVKVLDVKNGYASVKKADGTV Caenorhabditis_briggsae ------------------------------------------------------------ Loa_loa ------------------------------------------------------------ Brugia_malayi ------------------------------------------------------------ Ascaris_suum SPKHNSSNKPSKLFGFGKKSSNPSNNKSATSPPPVGKLK--------------------- Schistosoma_mansoni ------------------------------------------------------------ Hydra_magnipapillata ------------------------------------------------------------ Nematostella_vectensis ------------------------------------------------------------ Trichoplax_adhaerens ------------------------------------------------------------ Trio_Human DAEGSEREAEPIPKMKVLESPRKGAANAS------------------------------- Trad_Human ------------------------------------------------------------ Saccoglossus_kowalevskii ELADSGVLPATCKKLS-------------------------------------------- Branchiostoma_floridae SSPMNSPSGESSGSSSDRRFPFKEQGSGS------------------------------- Strongylocentrotus_purpuratus DKKDNTAGSPSIRRKFFDGLFHSFRPSKSRDTSPMGSKESLQKGKEHKEIPNTPKEIVEK Harpegnathos_saltator ------------------------------------------------------------ Apis_mellifera KDPFRGVSPDSPCRGSVL---SSTIPNMS------------------------------- Bombus_terrestris KDPFRGVSPDSPCRGSVLSTISSTIPNIS------------------------------- Nasonia_vitripennis ------------------------------------------------------------ Tribolium_castaneum ------------------------------------------------------------ Drosophila_melanogaster ------------------------------------------------------------ Drosophila_willistoni ------------------------------------------------------------ Drosophila_grimshawi ------------------------------------------------------------ Anopheles_gambiae ------------------------------------------------------------ Anopheles_aegypti ------------------------------------------------------------ Culex_quinquefasciatus ------------------------------------------------------------ Pediculus_humanus ------------------------------------------------------------ Ixodes_scapularis ------------------------------------------------------------ Caenorhabditis_elegans GKCPSYFLTMSDIPGTNFAEQIQYRREWQRRVDETDVEYGPSAFDTATSSTDNFDVLLEL Caenorhabditis_briggsae ------------------------------------------------------------ Loa_loa ------------------------------------------------------------ Brugia_malayi ------------------------------------------------------------ Ascaris_suum ------------------------------------------------------------ Schistosoma_mansoni ------------------------------------------------------------ Hydra_magnipapillata ------------------------------------------------------------ Nematostella_vectensis ------------------------------------------------------------ Trichoplax_adhaerens ------------------------------------------------------------ Trio_Human -----------------------------------------------------GSSPDAP Trad_Human ------------------------------------------------------------ Saccoglossus_kowalevskii -----------------------------------------------------EGRKSVP Branchiostoma_floridae -----------------------------------------------------SSPNNKR Strongylocentrotus_purpuratus GNKSVVPVSGHLDLGTTNNATTENASTESPKTNAANKSPLMRTQSANIGTAVISNEKMSP Harpegnathos_saltator ------------------------------------------------------------ Apis_mellifera -----------------------------------------------------KTNEERR Bombus_terrestris -----------------------------------------------------KTNEERR Nasonia_vitripennis ------------------------------------------------------------ Tribolium_castaneum ------------------------------------------------------------ Drosophila_melanogaster ------------------------------------------------------------ Drosophila_willistoni ------------------------------------------------------------ Drosophila_grimshawi ------------------------------------------------------------ Anopheles_gambiae ------------------------------------------------------------ Anopheles_aegypti ------------------------------------------------------------ Culex_quinquefasciatus ------------------------------------------------------------ Pediculus_humanus ------------------------------------------------------------ Ixodes_scapularis ------------------------------------------------------------ Caenorhabditis_elegans TTCER------------------------------------------------------- Caenorhabditis_briggsae ------------------------------------------------------------ Loa_loa ------------------------------------------------------------ Brugia_malayi ------------------------------------------------------------ Ascaris_suum ------------------------------------------------------------ Schistosoma_mansoni ------------------------------------------------------------ Hydra_magnipapillata ------------------------------------------------------------ Nematostella_vectensis ------------------------------------------------------------ Trichoplax_adhaerens ------------------------------------------------------------ Trio_Human AKDARASLGTLPLGKPRAGAASPLNSPLSSAVPSLGKEPFPPSSPLQKGGSFWSSIPASP Trad_Human ------------------------------------------RSTAVMRSQPARLPQASP Saccoglossus_kowalevskii SEETRITKSDKLKVGGEVRKNSLQMEKTSSSPTVKRKFFDGLMQSFRKPKSESPCPSPVP Branchiostoma_floridae KLLDNLKPNFWAGKGKEPSSPTRTQANFMGANGAAKSQMSPVKKRNVENRMSATSDCSMS Strongylocentrotus_purpuratus GSVSTGNGGGVAIDNKADNKAKGSPLHVISSSSSPSKDSGVSVRSKRASTGSLQKDGEVN Harpegnathos_saltator ----------------------------------------TKDPLRASTSEPATRATVSV Apis_mellifera NEIAA------TTSSKALATAAAATATAT-----------SVLQRPRTGGL----DQDSS Bombus_terrestris NELAGAAGSTISATSKTLATAAAVAATATGTATATATATTSVLHRPRTGTT----DQDSS Nasonia_vitripennis -------------------------------------TKDPLRGSTPEPSSSSTRSLLAG Tribolium_castaneum ----------------------------------------------------TKEASVSD Drosophila_melanogaster ------------------------------------------------------------ Drosophila_willistoni ------------------------------------------------------------ Drosophila_grimshawi ------------------------------------------------------------ Anopheles_gambiae ------------------------------------------------------------ Anopheles_aegypti ------------------------------------------------------------ Culex_quinquefasciatus ------------------------------------------------------------ Pediculus_humanus ------------------------------------------------------------ Ixodes_scapularis ------------------------------------------------------------ Caenorhabditis_elegans ------------------------------------------------------------ Caenorhabditis_briggsae ------------------------------------------------------------ Loa_loa ------------------------------------------------------------ Brugia_malayi ------------------------------------------------------------ Ascaris_suum ------------------------------------------------------------ Schistosoma_mansoni ------------------------------------------------------------ Hydra_magnipapillata ------------------------------------------------------------ Nematostella_vectensis --------------------------------------------------------RQKN Trichoplax_adhaerens ------------------------------------------------------------ Trio_Human ASRPGSFTFPGDSDSLQRQTPRHAAPGKDTDRMSTCSSASEQSVQSTQSNGSESSSSSNI Trad_Human RPYSSVPAGSEKPPKGSSYNPPLPPLKISTSNGSPGFEYHQPGDKFEASKQNDLGGCNGT Saccoglossus_kowalevskii RDSSPKPTG-RCSMESSPVKIRTREHEEVKRHSSASFDNRLSYTSTSSTEQEEASGEPNV Branchiostoma_floridae SHTS--------------------------------------DYSQRSEASESGSDYGVP Strongylocentrotus_purpuratus GKDSTESPSSQKKGGQSSSPARSQIPHGVTNRDQSGSPFNRSSYTSVSSSEPDDGTFTDH Harpegnathos_saltator PPTLTVPGLASKDKSHEHRTSSQPQLQRSHTGGLDYAQPRTPSPTKSRLNFLEGFKNTLR Apis_mellifera QS-P--------------------------------------SPSKSRLNFLEGFRSTLR Bombus_terrestris QTQS--------------------------------------SPSKSRLNFLEGFRSTLR Nasonia_vitripennis GGSKDSTTSSASNSPSRKAQPMHRSRTGGPLDGGGSDSPRTPSPTKSKLNFLEGFRNTLR Tribolium_castaneum ASTLWDPSPLRKTVSIPITPDSSKH-RKNIHYIHKANTIGIPSESDLSDASDSKVPNHSK Drosophila_melanogaster ------------------------------------------------------------ Drosophila_willistoni ------------------------------------------------------------ Drosophila_grimshawi ------------------------------------------------------------ Anopheles_gambiae ------------------------------------------------------------ Anopheles_aegypti ------------------------------------------------------------ Culex_quinquefasciatus ------------------------------------------------------------ Pediculus_humanus ------------------------------------------------------------ Ixodes_scapularis ------------------------------------------------------------ Caenorhabditis_elegans ------------------------------------------------------------ Caenorhabditis_briggsae ------------------------------------------------------------ Loa_loa ------------------------------------------------------------ Brugia_malayi ------------------------------------------------------------ Ascaris_suum ------------------------------------------------------------ Schistosoma_mansoni ------------------------------------------------------------ Hydra_magnipapillata -----------------------------------------VDELCRTKISEENSRDNVY Nematostella_vectensis TPGDSPSQGAPPAVPVGPVTTQGQVTPGSSTTTSTSPAFMARAGTMPDSISVRRPPGRNR Trichoplax_adhaerens ------------------------------------KSLSSSSLPSSMECFIDDPLELGI Trio_Human STMLVTHDYTAVKEDEINVYQGEVVQILASNQQNMFLVFRAATDQCPAAEGWIPGFVLGH Trad_Human SSMAVIKDYYALKENEICVSQGEVVQVLAVNQQNMCLVYQPASDHSPAAEGWVPGSILAP Saccoglossus_kowalevskii TYVPVIMNYSAVKEDEISVQKSEIVQILAANQYSMYLVHRPANQLSPAAEGWIPGYVLGH Branchiostoma_floridae TELDVKQSYTAIKEDEITVFKGELVQILATNQHNMFLVHRAATEESPAAEGWIPGDVLGC Strongylocentrotus_purpuratus CMAPIVEDYAAEKEDEICVSKGEVVQILAANQHNMFLVYRAADKQSPAIEGWIPGEVLNF Harpegnathos_saltator TRSPVRNNSIPVVPGARVRLAADWGKLHAGDELVVSHLDGPGLVVSPVNTKDELWIPASL Apis_mellifera PRSPVRNNSIPIVPGSRVRLTADWGKLHAGEELEIFRVDG-------------PGLIVSP Bombus_terrestris PRSPVRNNSIPIVPGSRVRLTADWGKLHAGEELEIFRVDG-------------PGLIVSP Nasonia_vitripennis ARSPVRIGTVPVAPGARVRLSADWGALRAGDDVVVRRLEGNGLVVTQADNAKQEHWIPAS Tribolium_castaneum TRVNFFEGFRNTLRSKHKSDPTTLEIQKDSDKNDMQRRWSEANQPTCDTHVMAPGTQARL Drosophila_melanogaster ------------------------------------------------------------ Drosophila_willistoni ------------------------------------------------------------ Drosophila_grimshawi ------------------------------------------------------------ Anopheles_gambiae ------------------------------------------------------------ Anopheles_aegypti ------------------------------------------------------------ Culex_quinquefasciatus ------------------------------------------------------------ Pediculus_humanus ------------------------------------------------------------ Ixodes_scapularis ------------------------------------------------------------ Caenorhabditis_elegans ------------------------------------------------------------ Caenorhabditis_briggsae ------------------------------------------------------------ Loa_loa ------------------------------------------------------------ Brugia_malayi ------------------------------------------------------------ Ascaris_suum ------------------------------------------------------------ Schistosoma_mansoni ------------------------------------------------------------ Hydra_magnipapillata KTPVATLQHVKLIPLDEAKSLDDLTKPFASGLVPIKILRKLENENLLTPNSSYDKAKKDS Nematostella_vectensis DRYMVTEDFRGKDKNQLSVRKGEYVYLVSCKKDDKSWMYVCNGAADKLGLVPAKVLVKKS Trichoplax_adhaerens RRSHHAYSLQRMNDLDNARKLSKDKFRSPGLIQKFFRLSQATQRSGSDPVLPLSTALPSL Trio_Human TSAVIVENPDGTLKKSTSWHTALRLRKKSEKKDKDGKREGKLENGYRK------------ Trad_Human LTKATAAESSDGSIKKSCS------------WHTLRMRKRAEVENTGKNEATGPRKPKDI Saccoglossus_kowalevskii EKENVPLEGGVGDNSTLNRRSWTSAHKMRKSKKEELRLARNSDSDVAMIRRRMSLERDDL Branchiostoma_floridae AKDGTEGENATKNKSWFHK------------KKRGEKKDKPSPTHSSKNGYR-------- Strongylocentrotus_purpuratus TGPTQHQSRGGDSPAPGAVAAPVAAKDSPSKKSWQGSLRLKGKLGKSPGKSPG-SKKESK Harpegnathos_saltator IPNSANSKVWSFRSRKADL----------------------------------------- Apis_mellifera VIG-KKEEFWIPASLVPNS------------SISRAWSFRPRRIDT---DGE-------- Bombus_terrestris VIGMKKEEFWIPASLVPNS------------SISRAWSFRPRRIDSAEGSGE-------- Nasonia_vitripennis LIPNSSVSRAWSFRPRKLN----------------------------------------- Tribolium_castaneum ITEWPDLSLGEVVTIIRYDTSQG-----------------------------------YL Drosophila_melanogaster ------------------------------------------------------------ Drosophila_willistoni ------------------------------------------------------------ Drosophila_grimshawi ------------------------------------------------------------ Anopheles_gambiae ------------------------------------------------------------ Anopheles_aegypti ------------------------------------------------------------ Culex_quinquefasciatus ------------------------------------------------------------ Pediculus_humanus ------------------------------------------------------------ Ixodes_scapularis ------------------------------------------------------------ Caenorhabditis_elegans ------------------------------------------------------------ Caenorhabditis_briggsae ------------------------------------------------------------ Loa_loa ------------------------------------------------------------ Brugia_malayi ------------------------------------------------------------ Ascaris_suum ------------------------------------------------------------ Schistosoma_mansoni ------------------------------------------------------------ Hydra_magnipapillata SKRSKTFSSSTLLRTASLR------------RKKRKDKDKTGSISNISEISSPIVNEPKQ Nematostella_vectensis ESNNNINEGMASIVCFFTS--------------KSVTLILLYRNEDKPRRGEVRKTKDEY Trichoplax_adhaerens KIDHPADDLSQKKSDPTSS----------------------------------------- Trio_Human ----------------SREGLSNKVSVKLLNPNYIYDVPPEFVIPLSEVTCETGETVVLR Trad_Human LGNKVSVKETNSSEESECDDLDPNTSMEILNPNFIQEVAPEFLVPLVDVTCLLGDTVILQ Saccoglossus_kowalevskii YGSKVTVKIPYCDEEYSRPNLGVLLRALFSSRLDPMDSLVNIDNKKAVKGPCCK------ Branchiostoma_floridae ------------TKSKDKDPHGTKVSVKLLNPNYMYDAAPEFLQQLTNTTVQLGDPATLT Strongylocentrotus_purpuratus IPRPRRRPSGKGIEDGELKKPGSKGHGKPVNASLYQPAAPAFTLPLINQSCHLGTTATLS Harpegnathos_saltator --------------------------------------------------MKNHATTELA Apis_mellifera ------------NVRLPQDMCAEENG----------PPAILTIPCSIRATAGGVARLVLE Bombus_terrestris ------------SVRLPQDIHAEENG----------PPAILTIPCSIRATAGGVARLVLE Nasonia_vitripennis -------------ADRIVPEAGSSASPGILGSGSKCPLPPCVSSAPTPIKANSGEIARLA Tribolium_castaneum VHTQTHSEELWLPAHALSNYNRKPWPFRFKKPAIIPELAPPEFRDSLRDVTVQSGAKIVL Drosophila_melanogaster ------------------------------------------------------------ Drosophila_willistoni ------------------------------------------------------------ Drosophila_grimshawi ------------------------------------------------------------ Anopheles_gambiae ------------------------------------------------------------ Anopheles_aegypti ------------------------------------------------------------ Culex_quinquefasciatus ------------------------------------------------------------ Pediculus_humanus ------------------------------------------------------------ Ixodes_scapularis ------------------------------------------------------------ Caenorhabditis_elegans ---------------------------------------PVVVEDMKDIEVVEGNDVEMC Caenorhabditis_briggsae ------------------------------------------------------------ Loa_loa ------------------------------------------------------------ Brugia_malayi ------------------------------------------------------------ Ascaris_suum ------------------------------------------------------------ Schistosoma_mansoni ------------------------------------------------------------ Hydra_magnipapillata SSSANSINFSIDSDLDELHNVQADNSLDITTQNVNSKQAPIIDNPLNDVIIKAGLPLKLS Nematostella_vectensis FTSMSEKLRRSIERFRSEDDDQSPCGSPTKCFMLFFSGSITFTEPLQDIAVNNTEYTELT Trichoplax_adhaerens ----------------FPHIDALMLNKGKRKNSIHGYDMPDVHTPLVDQEVLSSTSAMFT Trio_Human CRVCGRPKASITWKGPEHNTL---NNDGHYSISYSDLGEATLKIVGVTTEDDGIYTCIAV Trad_Human CKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDSGEITLKICNLMPQDSGIYTCIAT Saccoglossus_kowalevskii ------------------------------------------------------------ Branchiostoma_floridae CHVCGRPRPSVSWRGPDQMLL---SPSSRFSMSYSDNGDILLHIASTVLGDTGQYTCVAS Strongylocentrotus_purpuratus CQVCGRPRPMITWRDPQGDII---APSTRTNVWERDDGMVFLEIRAS------------- Harpegnathos_saltator VETQNAHGAVITWRREGEDRC---LRESDRYQFQQSAGFMYLQITGCQASDSGTYYCHVK Apis_mellifera ARRVERALVRWRKEGQ-RCD----IEESDRYRLYRTNDSLCLEIAPCLPSDSGIYHCRVE Bombus_terrestris ARRVERALVRWRKEGQ-RCDI---IEGTDRYRLFRTNDSLCLEIAPCLPSDSGIYHCLVE Nasonia_vitripennis VQVSQADGAVVAWRREGQDKD---IQESDRYRLRQSAGFFYLEITRCRPEDSGAYCCRIQ Tribolium_castaneum KCRVKNCGRSPKISWKKLEPNMCVLRNGRFMLGEEDEGVAMLIIDNVKLSDSGTYSVTIS Drosophila_melanogaster ------------------------------------------------------------ Drosophila_willistoni ------------------------------------------------------------ Drosophila_grimshawi ------------------------------------------------------------ Anopheles_gambiae ------------------------------------------------------------ Anopheles_aegypti ------------------------------------------------------------ Culex_quinquefasciatus ------------------------------------------------------------ Pediculus_humanus ------------------------------------------------------------ Ixodes_scapularis ------------------------------------------------------------ Caenorhabditis_elegans PIISSHTDFTVIWHGPA-----VDSKRARIQTNQLNS---RLLIKHVKKCDAGAYSVIAK Caenorhabditis_briggsae ------------------------------------------------------------ Loa_loa ------------------------------------------------------------ Brugia_malayi ------------------------------------------------------------ Ascaris_suum ------------------------------------------------------------ Schistosoma_mansoni ------------------------------------------------------------ Hydra_magnipapillata CIINAGSPPCITWGFNEKT-----VTSNDRYNITCTNNLCTFEIATSEPCDSGCYTVTAT Nematostella_vectensis CKISSPDFPYKVSWAWNDTP----LCDNDKYRISRTGDTHTLKLGPLAVADTGYYTCIAS Trichoplax_adhaerens CVIQAMDRPAITWFLNGNQL----LQSNYNIQIDSYNNEHQLRIQSVSQGDIGQYTCHAK Trio_Human NDMGSASSSASLRVLGPG------------------------------------------ Trad_Human NDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPSSTGNCTISGYTVEY---- Saccoglossus_kowalevskii -----------------PGAPGRPRVQEKPGGCVLVQWDPPYHTGNSTITAYTIEYMEQT Branchiostoma_floridae NEIGSVTTSGMLTVQGRPGAPGRPIMKEKTATSVTLTWAPPKETGNCPISAYTVEYSE-- Strongylocentrotus_purpuratus ---------------YRPGPPSIPILCERRPHSVTLQWEPSHNTGNAESVTYNVEYAQ-- Harpegnathos_saltator CDTGFCSAKISLSVIGRSNTRVRVL----------------------GSSRVEIDWEK-- Apis_mellifera HETGSCSAKIPLSIV-GIDTTNA----------------------------W-------- Bombus_terrestris HETGSCSAKIPLRII-GIDATNA----------------------------W-------- Nasonia_vitripennis CDNGSCSARIYLTVSGGTGTTWA--------------------------RVLDSTRIE-- Tribolium_castaneum NEGGICQSSALLTVTDPYPALQE---PQIQVLSCSS---VLLEWESEFYHQFWIEYCQ-- Drosophila_melanogaster ------------------------------------------------------------ Drosophila_willistoni ------------------------------------------------------------ Drosophila_grimshawi ------------------------------------------------------------ Anopheles_gambiae ------------------------------------------------------------ Anopheles_aegypti ------------------------------------------------------------ Culex_quinquefasciatus ------------------------------------------------------------ Pediculus_humanus ------------------------------------------------------------ Ixodes_scapularis ------------------------------------------------------------ Caenorhabditis_elegans NSFGVTSTVAFLSVISIPDPPTDFTVKISGDHEVRLKWKAESGLKYC------IEYRI-- Caenorhabditis_briggsae ------------------------------------------------------------ Loa_loa ------------------------------------------------------------ Brugia_malayi ------------------------------------------------------------ Ascaris_suum ------------------------------------------------------------ Schistosoma_mansoni ------------------------------------------------------------ Hydra_magnipapillata NHFGSTSCSCNVLIKTESNLSLIFKPIIRTNTSSSVNLEWNPPEY-----IFVKSYTI-- Nematostella_vectensis SPAGSARSTAKVTVLGVPEPPYKPYVKDLLSSSLVLAWEPNAIDGGNEVTAYTVEYKET- Trichoplax_adhaerens NFSGEVSTTALLKLR--------------------------------------------- Trio_Human ------------------------------------------------------------ Trad_Human REEGSQIWQQSVASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVRLPEYDA Saccoglossus_kowalevskii LGKNPSKWQLAVVAAVDLQFMMEDLNAGTSYRFRISAHNDIGISPPSDPSELVTISEVDG Branchiostoma_floridae QGTGVGIWQAAVAVAPETTQLVDDLTPGTVYQFRVSANNVVGISSPSEASEPITLRPDTE Strongylocentrotus_purpuratus ITHNTLHWQTSCANIAHTTHKVDALSAGASYKFRITAQNDVGCSDRGETTP-AVTLPDDT Harpegnathos_saltator REIGSASCSIECRILPSQQWVSVLKQANEPPSVLDMPPDASYSFRVVGDGGRMTSPSNVV Apis_mellifera --CDTIECN---------------------------------RSNGLTIKE-TSSIVTLS Bombus_terrestris --CDTIECN---------------------------------RSNGFTMNETTSSIVSLP Nasonia_vitripennis VDWEGQEIGKCDVEYRSMPSTNWTTALEDIENPPVVLDLLPGASYSFRVVGKNGSHTSAS Tribolium_castaneum LGTGEWLSPNNNRVINSQRYTVENLIPG---ETYSFRIIAVQN----KLVSLPSVAITLP Drosophila_melanogaster ------------------------------------------------------------ Drosophila_willistoni ------------------------------------------------------------ Drosophila_grimshawi ------------------------------------------------------------ Anopheles_gambiae ------------------------------------------------------------ Anopheles_aegypti ------------------------------------------------------------ Culex_quinquefasciatus ------------------------------------------------------------ Pediculus_humanus ------------------------------------------------------------ Ixodes_scapularis ------------------------------------------------------------ Caenorhabditis_elegans LDDSSPENWLIASTNIEKTHVSLRNFARNSYSFRVFAYNQRVRSAPSQCICICFDGTEM- Caenorhabditis_briggsae ------------------------------------------------------------ Loa_loa ------------------------------------------------------------ Brugia_malayi ------------------------------------------------------------ Ascaris_suum ------------------------------------------------------------ Schistosoma_mansoni ------------------------------------------------------------ Hydra_magnipapillata QQISSAEWETVITEWHDTIATINGLHSDHSYMFRIVAYYDTDSIITSEPSDPIKLFKETK Nematostella_vectensis ---GVSVWQAAVPFVAGESTLIDDLTPGATYQFRVSANNSIGISRPSEPFEVVMLETDTD Trichoplax_adhaerens ------------------------------------------------------------ Trio_Human ------MD---GIMVTWKDNFDSFYSEVAELGRGRFSVVKKCDQKGTKRAVATKFVNK-K Trad_Human AADGAT--------ISWKENFDSAYTELNEIGRGRFSIVKKCIHKATRKDVAVKFVSK-K Saccoglossus_kowalevskii SGDHP---------IQWQTNFDSVFSEMAEIGRGRFSFVRKCVQLTTGRDVAAKLISK-K Branchiostoma_floridae MVDGEEVP---RIRWQN---DFSAYSEISEIGRGRFSVVKMCCHMGSKREVAAKFISK-K Strongylocentrotus_purpuratus ALARRESN---LYWQHT---WSTDFNITREIGRGRFSSTHACTRSQQQRTLAAKFISK-R Harpegnathos_saltator TLSRLDAD---SGAEWEAKQFIGRYLELDELGNGRFGTVRRAKDRGTGQEVALKQTPR-H Apis_mellifera DSRKKVTK---NVEIEQ---FNNKYIELEELGIGRFARVCCAKEKGFDREVALKQISR-L Bombus_terrestris NSKKKLTN---DMEIEQ---FTNKYIELEELGTGRFARVCCAREKGFDREVALKQISR-S Nasonia_vitripennis PIVNLPLG---DGTAWEAEQFVARYLELDEIGKGRFAIVRRARDRGTGQEVALKQTPR-Q Tribolium_castaneum VADN---------LKWQQEQFKNRYLELEEISRGRFSIVRRAKDRGTNLEVALKQVTRRR Drosophila_melanogaster ------------------------------------------------------------ Drosophila_willistoni ------------------------------------------------------------ Drosophila_grimshawi ------------------------------------------------------------ Anopheles_gambiae ------------------------------------------------------------ Anopheles_aegypti ------------------------------------------------------------ Culex_quinquefasciatus ------------------------------------------------------------ Pediculus_humanus ------------------------------------------------------------ Ixodes_scapularis ------------------------------------------------------------ Caenorhabditis_elegans ------------------------------------------------------------ Caenorhabditis_briggsae ------------------------------------------------------------ Loa_loa ------------------------------------------------------------ Brugia_malayi ------------------------------------------------------------ Ascaris_suum ------------------------------------------------------------ Schistosoma_mansoni ------------------------------------------------------------ Hydra_magnipapillata LTHKP-------CEIKWLGNIEEHYQICGELGRGRFSVVKRCVRKNTKEEFAAKIFRR-R Nematostella_vectensis DDVTPTSSPTHKSAVSWKNDIDQYYNIYAELGRGRYAVVKKCVEKSTGKEFAAKMVKK-R Trichoplax_adhaerens --DDNYDN---IINWSWKEYFYNSYNLYDEIGKGKFADVKHCTHRETLKEFAVKIYQK-D Trio_Human LMKRDQVTHELGILQSLQHPLLVGLLDTFETPTSYILVLEMADQGRLLD---CVVRWGSL Trad_Human MKKKEQAAHEAALLQHLQHPQYITLHDTYESPTSYILILELMDDGRLLD---YLMNHDEL Saccoglossus_kowalevskii LTTVDRVENEIAILRSLQHPHICEYYDAFDTAMNLILILELIPNGRLFD---YIVSKPLF Branchiostoma_floridae YLTKEAADNEVSILQSLQHPHLNTVHEAYDVAQSLIIILELIPHGRLLD-WIVLNHRGNY Strongylocentrotus_purpuratus LMDLEQVQHEASMMQPLQHPLICSLHATYETHGQYILVLDLIPDGRILE---YLVSLSQV Harpegnathos_saltator KQSRSLTRAEYDLLAAAHHTNIVRAFALFENAPRPGVDTIVLELVKGPTLFAYLSEKMEY Apis_mellifera KQPLSLTRAEYDLLRNIRHDNIVRAFALFEDTPQPDIDTIVLELVKGSTLFIYLGEQIEY Bombus_terrestris KQPLSLTRAEYDLLRSIRHDNIVRAFALFEDTPQPDIDTIVLELVRGSTLFAYLGEQVEY Nasonia_vitripennis KQSRSLTRAEYDLLASTHHGNIVRAFALFENAPQLGVDTIILELVRGPTLFCYLSKKSEY Tribolium_castaneum QSH-HVTQAEYGLLAGMQHVNVIRAMALFDNAPQPGIDTIVLELVRGPLLFTYLCEKEEY Drosophila_melanogaster ------------------------------------------------------------ Drosophila_willistoni ------------------------------------------------------------ Drosophila_grimshawi ------------------------------------------------------------ Anopheles_gambiae ------------------------------------------------------------ Anopheles_aegypti ------------------------------------------------------------ Culex_quinquefasciatus ------------------------------------------------------------ Pediculus_humanus ------------------------------------------------------------ Ixodes_scapularis ------------------------------------------------------------ Caenorhabditis_elegans ------------------------------------------------------------ Caenorhabditis_briggsae ------------------------------------------------------------ Loa_loa ------------------------------------------------------------ Brugia_malayi ------------------------------------------------------------ Ascaris_suum ------------------------------------------------------------ Schistosoma_mansoni ------------------------------------------------------------ Hydra_magnipapillata LISKETVESEVAVMQSLNHPGVVKVFEIYEAPKSLIIIQQMLSGGRLFD---HIVVMDML Nematostella_vectensis MLDPVDIDREVTVLRMLKHPNLCIFLDAYDTPKNYIIVTELLAGGRLFD---YLVVMDAL Trichoplax_adhaerens IISKAGVQRELDIWQPLQHAKICSFHEVYDCEDIYMIVMEYLPGGRLFD---YLCDNDCI Trio_Human TEGKIRAHLGEVLEAVRYLHNCRIAHLDLKPENILVDESLAKPTIKLADFGDAVQL--NT Trad_Human MEEKVAFYIRDIMEALQYLHNCRVAHLDIKPENLLIDLRIPVPRVKLIDLEDAVQI--SG Saccoglossus_kowalevskii TESIAVGYLHQMISAIEYLHNCRISHLDIKPENFAVEANNVTCRVKLIDFGDAIN--IGS Branchiostoma_floridae TEQHVVGYVVQVMEAVQYLHNCRVAHLDIKPENIMVDGDSLTPKIKLIDFGDAKQI-SNS Strongylocentrotus_purpuratus TERQVIGFIRQLVQAVNYLHSNGIIHLDIKPENVMMEKALGRAQIKLIDFGDAMDLWSSP Harpegnathos_saltator TEATAARYTGQLLSALHWLHCRDRAHLDVKPENILVDQETDVVKVIDLGEA------VRA Apis_mellifera TEATVAKYTGQLLSALYWLHSRKRAHLDLKPENVLIDEKTGVVKL----IDLGEAV-RAV Bombus_terrestris TESTVAKYTGQLLSALQWLHSRKQAHLDLKPENILVDSDTGIVKL----IDFGEAI-RAV Nasonia_vitripennis TESMASKFANQLLSALQWLHHRDKAHLDLKPENVLVDQDTGIVKLIDLGEA------VRG Tribolium_castaneum TEATVKTYSRQLMSALLWLHQKDISHLDIKPENVMVDLSG----SSPLLKLVDFGDSVNT Drosophila_melanogaster ------------------------------------------------------------ Drosophila_willistoni ------------------------------------------------------------ Drosophila_grimshawi ------------------------------------------------------------ Anopheles_gambiae ------------------------------------------------------------ Anopheles_aegypti ------------------------------------------------------------ Culex_quinquefasciatus ------------------------------------------------------------ Pediculus_humanus ------------------------------------------------------------ Ixodes_scapularis ------------------------------------------------------------ Caenorhabditis_elegans ------------------------------------------------------------ Caenorhabditis_briggsae ------------------------------------------------------------ Loa_loa ------------------------------------------------------------ Brugia_malayi ------------------------------------------------------------ Ascaris_suum ------------------------------------------------------------ Schistosoma_mansoni ------------------------------------------------------------ Hydra_magnipapillata TENLAKLYIIQLLRAVQYIHSLSIAH---------------------------------- Nematostella_vectensis TEKVAIGYMHQVVEGVQHLHDLNIVHLDLKPQNLLLDGG---PLPKVKIIDFGSAHILSG Trichoplax_adhaerens NELQIQNYMKQIGDGLRFLHQMSVVKVNLKPENIILEG----CEHKFIKLVGFSHAICLD Trio_Human TYYIHQLLGNPEFAAPEIILGNPVSLTSDTWSVGVLTYVLLSGVSPFLDDSVEETCLNIC Trad_Human HFHIHHLLGNPEFAAPEVIQGIPVSLGTDIWSIGVLTYVMLSGVSPFLDESKEETCINVC Saccoglossus_kowalevskii KLFVHGLVGSPEFAAPELVNGHPVCLNTDMWGVGVLTYVMLSGVSPFLDESIEETCVNIA Branchiostoma_floridae RFYIHNLLGSPEFAAPELVNGHPVCLNTDMWSVGVLTYVLLSGVSPFQDESVEETCTNIS Strongylocentrotus_purpuratus PPFYHELNANPEFCSPELLGGNEIDYGTDVWSIGALSYVMLSGISPFLDESLEETNMNII Harpegnathos_saltator PVDEVVPPADLEFAAPESVLGRPTGPYTDMWAIGVFIYVLLSGLSPFLDDSIEETTANIL Apis_mellifera PLDEVVPPVDLEFAAPESVLGKPTGSYTDMWAAGVFLYVLLSGLSPFLDDSIEETTANIL Bombus_terrestris PLDQVPPPVDLEFAAPESVLGKPTGSYTDMWAAGVFLYVLLSGLSPFLDDSIEETTANIL Nasonia_vitripennis PVEEVVPPADLEFAAPESVLGRPVGTYTDMWAAGVFIYVLLSGLSPFLDDSVEETTTNIL Tribolium_castaneum SKSVILPPACLEFASPELVLGQPVGKHTDCWAAGVFLYVLLSGVSPFLDDSMEETTANIL Drosophila_melanogaster ------------------------------------------------------------ Drosophila_willistoni ------------------------------------------------------------ Drosophila_grimshawi ------------------------------------------------------------ Anopheles_gambiae ------------------------------------------------------------ Anopheles_aegypti ------------------------------------------------------------ Culex_quinquefasciatus ------------------------------------------------------------ Pediculus_humanus ------------------------------------------------------------ Ixodes_scapularis ------------------------------------------------------------ Caenorhabditis_elegans ------------------------------------------------------------ Caenorhabditis_briggsae ------------------------------------------------------------ Loa_loa ------------------------------------------------------------ Brugia_malayi ------------------------------------------------------------ Ascaris_suum ------------------------------------------------------------ Schistosoma_mansoni ------------------------------------------------------------ Hydra_magnipapillata --------------PPEIITGKAVSLLTDMWSIGVVVYVLLSGVSPFFSDNSTRLCENIT Nematostella_vectensis SPVNHKVYGSPEFAAPELIMEEPLTFKTDTWSIGVITYVMLSGVSPFQADTTDEMCERIR Trichoplax_adhaerens DCHMIDFDGDVEFAAPEVISQSGISSMSDM---------CLTGLSPFYKKKKKDTCKMIV Trio_Human RLDFSFPDDYFKGVSQKAKEFVCFLLQEDPAKRPSAALALQEQWLQAGNGRSTGV----- Trad_Human RVDFSFPHEYFCGVSNAARDFINVILQEDFRRRPTAATCLQHPWLQPHNGSYSKIP---- Saccoglossus_kowalevskii KIDYSFPQEYFSDISQAATNFISNLLKEDPEERLSAKACLENAWIQAANTMSVNVASSCR Branchiostoma_floridae KVDYCFPEEYFTEVTDLAKQFVASFLLADPSQRAQAAAGLDHPWVQHTSSAGPESG-LAH Strongylocentrotus_purpuratus RVDYSFPEEYFKNVSQNAKHFITGLLHADSSERKTTSECLMNHWFAQTYSAQDDPA---L Harpegnathos_saltator KCDFCFPDEYFETISSDAKNLLKRLLCLHSEDRINAELCLASTWLKRATALNTRLV---- Apis_mellifera KCDFCFPDEYFKDISSDVKNLLETLLCLRGEDRATAQLILSSPWFKISIGAT-------- Bombus_terrestris KCDFCFPDEYFNEISTDVKNLLETLLRLHGEDRATAQLILSSPWFKISIGAT-------- Nasonia_vitripennis KCDFCFPDEYFVMISNEAKDLLGRLLCLRSEDRATAEVSLASPWFKVSKGAT-------- Tribolium_castaneum KCDFCFPDDYFAEISPEAKSLVNNLLVLVPSQRINMEECLKSTWMTTDQKTVVIPS---- Drosophila_melanogaster ------------------------------------------------------------ Drosophila_willistoni ------------------------------------------------------------ Drosophila_grimshawi ------------------------------------------------------------ Anopheles_gambiae ------------------------------------------------------------ Anopheles_aegypti ------------------------------------------------------------ Culex_quinquefasciatus ------------------------------------------------------------ Pediculus_humanus ------------------------------------------------------------ Ixodes_scapularis ------------------------------------------------------------ Caenorhabditis_elegans ------------------------------------------------------------ Caenorhabditis_briggsae ------------------------------------------------------------ Loa_loa ------------------------------------------------------------ Brugia_malayi ------------------------------------------------------------ Ascaris_suum ------------------------------------------------------------ Schistosoma_mansoni ------------------------------------------------------------ Hydra_magnipapillata QLRYKFPGDFFGDISDEAKDFIEDLLVAEQSLRPNAKKCLESTWLITDTVNNELYE--KS Nematostella_vectensis KANFSFPNKHFSAISSQAKDFISSLLIADI------------------------------ Trichoplax_adhaerens SGSYD--STFLKDMSDDCRNFIKHCLAIDPW----------------------------- Trio_Human LDTSRLTSFIERRKHQNDVRPIRSIKNFLQSRLLPRV----------------------- Trad_Human LDTSRLACFIERRKHQNDVRPIPNVKSYIVNRVNQGT----------------------- Saccoglossus_kowalevskii LDTSRLNAFIDRRKTQNDIRPISPMKSFYLIGMQSRV----------------------- Branchiostoma_floridae LDTSRLTAFIERRSHQNDTKPVLPMQAFYPMGMTSRV----------------------- Strongylocentrotus_purpuratus MHRARLEDFIHRRKTQHNFVSVKINRR--------------------------------- Harpegnathos_saltator NASNHLICIRLQDKCRIGSSISAEKFVTWISWKRANRSANQARREHTEELYRTAKKKYKE Apis_mellifera IPSSRMVAFIDRRAHRSKHHQDRNSSFYS------------------------------- Bombus_terrestris IPSSRMVAFIERRAHRSKSHQDRNSSFYS------------------------------- Nasonia_vitripennis IPSTRMAAFTERRAHCSKSHRDHRNSFYT------------------------------- Tribolium_castaneum SKLKTFMLRRHPMNLPTTPTSPAYFNNEQNVCKT-------------------------- Drosophila_melanogaster ------------------------------------------------------------ Drosophila_willistoni ------------------------------------------------------------ Drosophila_grimshawi ------------------------------------------------------------ Anopheles_gambiae ------------------------------------------------------------ Anopheles_aegypti ------------------------------------------------------------ Culex_quinquefasciatus ------------------------------------------------------------ Pediculus_humanus ------------------------------------------------------------ Ixodes_scapularis ------------------------------------------------------------ Caenorhabditis_elegans ------------------------------------------------------------ Caenorhabditis_briggsae ------------------------------------------------------------ Loa_loa ------------------------------------------------------------ Brugia_malayi ------------------------------------------------------------ Ascaris_suum ------------------------------------------------------------ Schistosoma_mansoni ------------------------------------------------------------ Hydra_magnipapillata ITLSRLAAFNARRHYQYEISNNKLPGTQNISPLKKESGNNR------------------- Nematostella_vectensis ------------------------------------------------------------ Trichoplax_adhaerens ------------------------------------------------------------ Trio_Human ---- Trad_Human ---- Saccoglossus_kowalevskii ---- Branchiostoma_floridae ---- Strongylocentrotus_purpuratus ---- Harpegnathos_saltator AIYQ Apis_mellifera ---- Bombus_terrestris ---- Nasonia_vitripennis ---- Tribolium_castaneum ---- Drosophila_melanogaster ---- Drosophila_willistoni ---- Drosophila_grimshawi ---- Anopheles_gambiae ---- Anopheles_aegypti ---- Culex_quinquefasciatus ---- Pediculus_humanus ---- Ixodes_scapularis ---- Caenorhabditis_elegans ---- Caenorhabditis_briggsae ---- Loa_loa ---- Brugia_malayi ---- Ascaris_suum ------- Schistosoma_mansoni ---- Hydra_magnipapillata ---- Nematostella_vectensis ---- Trichoplax_adhaerens ----