Gene IRAK-0_m-1 (S.moellendorffii)

IRAK-0_m-1

Species: S.moellendorffii
Alias: IRAK-0_m-1
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-0

Sequence

Name Sequence Type Origin Length Description Download
IRAK-0_m-1.AA Protein None 810 None Fasta, JSON
IRAK-0_m-1.NA RNA None 2433 None Fasta, JSON
IRAK-0_m-1.kin_dom Protein Kinase Domain None 197 None Fasta, JSON

Protein domain

Protein domains of IRAK-0_m-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IRAK-0_m-1.AA TKL 507-765 21 4.3e-66 225.88 In-house 1-364 (364) Show / Hide 
Range on Protein: 507-765
Range on HMM: 1-364/364
Sequence Identity: 21% (79 aa)

LGKGSFATVYKGVLHN---------GRQVAIKQAKASTRSG----------------------------EMFRKELKLLARTHHSCVVNLIGYCEQEK--
.|.|.|..||||....         |. ||.|. |    .                             . ...|.... |..|  .| ..||| ...  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-------------LLVFEFMSRGTLHDNLYSSHSLEWTTRIKISAQAARGLEYLHRYVS-----PSVTHRDVKSSNILLDCDWN--------------AK
              .| |....|.|...|       |  |.... ..|||..|||         | . ||| ||.|||.| .|.              .|
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCK

VSDFGLSVCG-----PQDNATHLS-----------NLTIVGTPGYLDPDY----------------GNSSQLTTTSDVYSFGVVLLELMSGQKPID-LSR
..||||| .       .|..|.             . |..|||... |                   .... .. .||||||.|| |......| . .  
ICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPY

EIQSLV-------AWVLDLVER----DEWSSVLDARLAVPLEPEPLYRAVKLALECTKASGKERPSMSHVAKTL
. . .        ..| |  .|    ..|....  . . . .|  . .  ||. .| ..  ..|||.. . |.|
MPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHH--K-M-CPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAK-0_m-1.AA IRAK 501-765 26 1.2e-50 174.6 In-house 1-317 (317) Show / Hide 
Range on Protein: 501-765
Range on HMM: 1-317/317
Sequence Identity: 26% (84 aa)

YCDDSILGKGSFATVYKGVLHNGR-QVAIK--QAKASTRSGEM---FRK---ELKLLARTHHSCVVNLIGYC-EQEKL-LVFEFMSRGTLHDNLYSSH--
.  |  .|.| |..||.|...|    .|.|   . |..  .|.   |.    |||...| .|  .| | ||| | ... ||...|. |.|.| |      
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

-S---LEWTTRIKISAQAARGLEYLHRYVSP-SVTHRDVKSSNILLDCDWNAKVSDFGLSVCG---PQDNATHL---SNLTIVGTPGYLDPDYGN--SSQ
 .   |.| .|..|.  .|.|...||   .  .. |.|.||.||||| . ..| .||||  .|   .   .. .      ...||  |. |.. .  . |
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQ

LTTTSDVYSFGVVLLELMSGQKPIDLS-REIQSLVAWVLDLVERDE-WSSVLD------------------------ARLAVPLEPEPLYRAVKLALECT
||. .||||||.||||. .|... .   .| . |.  . .. |      | .                          ... |..|.       .|..|.
LTKKTDVYSFGIVLLEVLTGCRAVYDDRPEHYYLKDLCEEIMEEWGHLDSCQSTLWVGVATDAWAAPRRMQIYEKFIDHRMPPCPPNMEKEMCQCACCCG

KASGKERPSMSHVAKTL
 .  ..|..|  | ..|
HHRANRRCDMAWVMQQL
Kinase IRAK-0_m-1.AA TKL-Unique 503-697 29 2.9e-45 156.68 In-house 1-233 (290) Show / Hide 
Range on Protein: 503-697
Range on HMM: 1-233/290
Sequence Identity: 29% (69 aa)

DDSILGKGSFATVYKGVLHNGRQVAIKQAKA----STRSGEMFRKELKLLARTH-HSCVVNLIGYCE----QEK--LLVFEFMSRGTLHDNLY-------
. . .| |....||||. ..| .||||| .     | .. . |..|.... . | |  .| ..|||     ...   .| |....|.|.|.|        
FWNKIGEGGYGQVYKGK-WRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

---SSHSLEWTTRIKISAQAARGLEYLHRYVSPSVTHRDVKSSNILLDCD-----WNAKVSDFGLSVCGPQDNATHLSNL------TIVGTPGYLDPDYG
   ... | .  |.|.  ..|.|..|||..  | ..||| ||||.|.| .     ||.|..|||||    ..|.. ....      | .|.. .. |   
NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVL

NS--SQLTTTSDVYSFGVVLLELMSGQK------P
..  .| .. |||||||.|| |. ...       |
RMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKP
Kinase IRAK-0_m-1.AA Pkinase 501-695 25 1.8e-43 154.78 Pfam 1-209 (293) Show / Hide 
Range on Protein: 501-695
Range on HMM: 1-209/293
Sequence Identity: 25% (55 aa)

YCDDSILGKGSFATVYKGVLHNGRQ-VAIKQAKASTRSGEMFRK-----ELKLLARTHHSCVVNLIGYCE--QEKLLVFEFMSRG----TLHDNLY--SS
|.  ...|.|||..|||.. .. .. ||.|. | .... .. .      |.....| .| ..| |....|  ..  .|.|..  |     |.| .   ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

HSL--EWTTRIKISAQAARGLEYLHRYVSPSVTHRDVKSSNILLDCDWNA----KVSDFGLSVCGPQDNATHLSNLTIVGTPGYLDPDYGN-SSQLTTTS
 ..  .. . ...  | .|||||.|.    .. |||.|..|||.| . .     |..||||. .    .     . |..|||.|. |   . ..  .. .
GCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DVYSFGVVLLELMSGQ
|..|.|..| |...|.
DMWSCGCILYEMLCGR
Kinase IRAK-0_m-1.AA LRRK 489-699 23 1.4e-34 119.78 In-house 1-284 (351) Show / Hide 
Range on Protein: 489-699
Range on HMM: 1-284/351
Sequence Identity: 23% (69 aa)

LSASELQAATNNYCDDSILGKGSFA-TVYKGVLHN---------------------------GRQVAIKQAKA---------------------------
|   |.            .|.|.|. .||.. . .                           .  ||||. .                            
LKIEEQ------------IGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVE

--------STRSGEMFRKELKLLARTHHSCVVNLIGYCEQEKLLVFEFMSRGTLHDNLYSSH---------SLEWTTRIKISAQAARGLEYLHRYVSPSV
        ..|.   ||.|. .. . .|...|.|.|.| .   .| |... |.|.. | ...         .. |....||. | |.|.||||.  .|..
DMDQNHEDCCRAFREFRHEVWIMSHLNHPNIVSLKGFCIHPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHS-HNPPI

THRDVKSSNILL---D---------CDWNAKVSDFGLSVCGPQDNATHLS-NLTIVGTPGYLDPDYGN---SSQLTTTSDVYSFGVVLLELMSGQ-KPID
 ||| || ||||   .          . .||..|||.|       ..| .   . ||.||.. |   .    .. |. .|.||||..| ||...|  | |
IHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISR--MF-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFD
Kinase IRAK-0_m-1.AA S_TKc 501-769 23 9.7e-33 116.01 SMART 1-231 (231) Show / Hide 
Range on Protein: 501-769
Range on HMM: 1-231/231
Sequence Identity: 23% (66 aa)

YCDDSILGKGSFATVYKGVLHN-GRQVAIKQAKASTRSGEMFRKELKLLARTHHSCVVNLIGYCE-QEKLLVFEFMSR--GTLHDNLYSSHS------LE
|    ..|||.|..|||.. .. ||.||||. |      |..|.|...| . ||  .|.|..... ..  .|.|...   |.|.| . .  .      . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP

WTTRIKISAQAARGLEYLHRYVSPSVTHRDVKSSNILLDCDWNAKVSDFGLSVCGPQDNATHLSNLTIVGTPGYLDPDYGNSSQLTT-TSDVYSFGVVLL
  .  .. .| ...|||.|   |  . |||.| .|||||   . |..||||.              |..||| |. |      . ..  .|..|.|..| 
E-HARFYMYQICCALEYCH---SHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

ELMSGQKPIDLSREIQSLVAWVLDLVERDEWSSVLDARLAVPLEPEPLYRAVKLALECTKASGKERPSMSHVAK-----TLEEVL
|...|. | .   ..| .   ..                           |  .   | .   ..||.   . .      . . .
EMLCGYPPFP---QMQMMFKKIG------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAK-0_m-1.AA LISK 506-697 26 2.2e-32 102.35 In-house 1-238 (296) Show / Hide 
Range on Protein: 506-697
Range on HMM: 1-238/296
Sequence Identity: 26% (64 aa)

ILGKGSFATVYKGVLH-NGRQVAIKQAK------ASTRSGEMFRKELKLLARTHHSCVVNLIGYCEQ-EKLL--VFEFMSRGTLHDNLYSSH----SLEW
..|||.|. |||| .   |. .|||. .              . .|.... .  |  .|. .| |.. .. |  | |... |.||. | ..      | |
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW

TTRIKISAQAARGLEYLHRYVSPSVTHRDVKSSNILLD----CDWNAKVSDFGLS-VCGPQDNA------------------------------THLSNL
. |.||.   |.|..|||   |  . ||| || |.|..     .|..|| |||.  .   ..|                               .  . .
PQRVKIALDIACGMSYLH---SMNIIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESDPCMDNDMPMKRKIPKKCMNQRKRRM

TIVGTPGYLDPDYGNSSQLTTTSDVYSFGVVLLELMSGQKP
||.|||    |   . .. ....||.|||.||.|.  . |.
TICGTPYWMAPEMLLGQSYDESCDVFSFGIVLCEIITRVKA
Kinase IRAK-0_m-1.AA TK 501-642 16 2.6e-31 101.63 In-house 1-298 (486) Show / Hide 
Range on Protein: 501-642
Range on HMM: 1-298/486
Sequence Identity: 16% (50 aa)

YCDDSILGKGSFA---TVYKGVLHNGR--------------------------QVAIKQAKA-STRSGEMFRK-----------------ELKLLA--RT
      ||.| |    .|||| .....                          .||.|. |. .. | |.|.                  |.|..     
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

HHSCVVNLIGYCEQEK--------------LLVFEFMSRGT----LHDNLYSSHS---------------------------------------------
||  .|.|.|.| |..              ..| |.|. |     |.| | ...                                              
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LEWTTRIKISAQAARGLEYLHRY----VSPSVTHRDVKSSNILLDCDWN-----------AKVSDFGLS
                               |   ... ...|.|.|.||||.     . . . |||.   |.|.. . .           .|..|||||
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS
Kinase IRAK-0_m-1.AA Pkinase_Tyr 507-642 30 7.2e-30 101.79 Pfam 7-158 (270) Show / Hide 
Range on Protein: 507-642
Range on HMM: 7-158/270
Sequence Identity: 30% (47 aa)

LGKGSFATVYKGVLH-----NGRQVAIKQAKASTRSG----EMFRKELKLLART-HHSCVVNLIGYCE--QEK---LLVFEFMSRGTLHDNLYS----SH
||.|.| .||||...     .. .||.|  | .. .     |.| .|.|..    ||  .|.|.| |   .|    ..|.|.|  | |.| | .     .
LGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQ

SLEWTTRIKISAQAARGLEYLHRYVSPSVTHRDVKSSNILLDCDWNAKVSDFGLS
.|   . .....| |.|.|||..       |||.   |.|....  .|..||||.
PLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLA
Kinase IRAK-0_m-1.AA STE 501-695 21 7.8e-29 99.0 In-house 1-265 (359) Show / Hide 
Range on Protein: 501-695
Range on HMM: 1-265/359
Sequence Identity: 21% (60 aa)

YCDDSILGKGSFATVYKGVLHN----------------GRQVAIKQAKAST------------------RSGEMFRKELKLLARTH--HSCVVNLIGYCE
. . ...|||.| ||||.. |.                |. .|||| . ..                     . . ||.|.. . .  |  .|. .|...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

---------QEKLLVFEFMSRGTLHDNLYSSHSL---------------EWTTRIKISAQAARG-LEYLHRYVSPSVTHRDVKSSNILLDCDWNAKVSDF
         .|  .. |.|. |.| | . . ..                | .  ..|  |  .| |.|||.     . |||.|..||||     .| .||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPE-SQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDF

GLSVCGPQDNA------------THLSNL-TIVGTPGYLDPDYGNS------SQLTTTSDVYSFGVVLLELMSGQ
|.. .  ...|            |  ..  |.|||| .  |   .       .. .| .|..|.| ...|.  |.
GVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK
Kinase IRAK-0_m-1.AA Dicty4-Unclassified 504-708 32 2.5e-28 94.08 In-house 4-215 (263) Show / Hide 
Range on Protein: 504-708
Range on HMM: 4-215/263
Sequence Identity: 32% (73 aa)

DSILGKGSFATVYKGVLHNGRQVAIK---QAKASTR--SGEMFRKELKLLARTHHSCVVNLIGYCEQE------KLLVFEFMSRGTLHDNLY-------S
|  .||| |. |.||.   |. ||.|     | . |    . |.||  .|    |   | . |||            | ||| .|.|             
DQFIGKGHFSKVHKGNWK-GKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQ

SHSLEWTTRIKISAQAARGLEYLHRYVSPSVTHRDVKSSNILLDCDWNAKVSDFGLSVCGPQDNATHLSNLTIVG-TPGYLDPDYGNSSQLTTTSDVYSF
. .|. |  ||.    |.|. .||   .  . |||.||||||.| . |.|. |||.|     |.     |.| .. ||    |        .  |||||.
PIKLDDTLIIKYAFDIAQGMQHLH---TRNFIHRDIKSSNILMDKHFNIKIADFGISRV--IDFNF---NMTTIAGTPKWESPECLMHESYNQKSDVYSY

GVVLLELMSGQKPIDLSREIQSLV
...| ||. |  |     |||| .
AMMLYELATGDEPY---QEIQSIM
Kinase IRAK-0_m-1.AA Dicty4 501-642 31 3.1e-28 91.42 In-house 1-161 (277) Show / Hide 
Range on Protein: 501-642
Range on HMM: 1-161/277
Sequence Identity: 31% (52 aa)

YCDDSILGKGSFATVYKGVLHNGRQVAIKQA---KASTRSGEM--FRKELKLLARTHHSCVVNLIGYCE----QE--KLLVFEFMSRGTLHDNLYS----
.  ....|||||..||||    | .||.| .   .   .. ..  |||| ....   |  .. . |.|     .    . | |.|..|.|.  | .    
INIEQRIGKGSFGEVYKGTWR-GKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSE

---SHSLEWTTRIK---ISAQAARGLEYLHRYVS--PSVTHRDVKSSNILLDCDWNAKVSDFGLS
   | .|.|.....   .   ||||. .||   .  | . ||| ||.|.| | .|..||.|||||
QQQSIKLDWPLIKRAMRMAFDAARGMNWLH---CCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLS
Kinase IRAK-0_m-1.AA MLK 506-642 27 1.6e-24 82.04 In-house 6-180 (291) Show / Hide 
Range on Protein: 506-642
Range on HMM: 6-180/291
Sequence Identity: 27% (48 aa)

ILGKGSFATVYKGVLHNGR----QVAIKQAKAST----------RSGEMFRKELKLLARTH-HSCVVNLIGYCEQE-K--LLVFEFMSRGTLHDNLYSSH
..|.|||  |.||. .| .     ||.|...|..          .  ||. ..|. | .   |.|.. . | | |. .  ..| |... | |.. |..  
WIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGAR

S--------------LEWTTRIKISAQAARGLEYLHRYVSPSVTHRDVKSSNILLD------CDWNAKVSDFGLS
|                    .... | |||..|||    . . ||| ||.|||.|      .. ..|..|||.|
SKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTS
Kinase IRAK-0_m-1.AA TyrKc 501-765 24 7.7e-20 73.16 SMART 1-280 (280) Show / Hide 
Range on Protein: 501-765
Range on HMM: 1-280/280
Sequence Identity: 24% (76 aa)

YCDDSILGKGSFATVYKGVLHNGRQVAIKQAKASTRSGEMFRKELKLLART--HHSCVVNLIGYCE---------QEKLLVFEFMSRGTLHDNL-YSSHS
   . .|| | | .||||..   .|||.|  |...   |.|..|.... .   || ..|.|.|.|          .  ..|.|.|. | |.| | .. . 
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

LEWTTRIKISAQAARGLEYLHRYVSPSVTHRDVKSSNILLDCDWNAKVSDFGLSVCGPQD-------NATH-----LSN--LTI-------VGTPGYLDP
| . . .... |.|.| ||||.     . |||    |.|.. .  .|.||||||  .  |          .      ..  | |                
LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--------

DYGNSSQLTTTSDVYSFGVVLLELMS-GQKPIDLS----REIQSLVAWVLDLVERDEWSSVLDARLAVPLE---------PEPLYRAVKLALECTKASGK
   | .  || |||.||||.. |... ||.|         . | ....| .             |.  | .         |. .|   .. ..| ..  .
---NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQ-----------GYRMPQPPNDYPMSFVCCPDEMY---QIMKQCWHEDPE

ERPSMSHVAKTL
.||..| . . .
DRPTFSEIHECF
Kinase IRAK-0_m-1.AA MLK 672-697 34 4e-06 17.35 In-house 210-235 (291) Show / Hide 
Range on Protein: 672-697
Range on HMM: 210-235/291
Sequence Identity: 34% (9 aa)

SSQLTTTSDVYSFGVVLLELMSGQKP
... .  .||.|.|||| |..... |
CEKYSEKCDVWSWGVVLWEMLTREVP
Kinase IRAK-0_m-1.AA TK 672-697 43 2.8e-05 12.81 In-house 363-394 (486) Show / Hide 
Range on Protein: 672-697
Range on HMM: 363-394/486
Sequence Identity: 43% (14 aa)

SSQ-----LTTTSDVYSFGVVLLELMS-GQKP
|..      || |||.||||.. |... ||.|
SEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEP
Kinase IRAK-0_m-1.AA Pkinase_Tyr 676-697 52 0.000128 16.27 Pfam 192-214 (270) Show / Hide 
Range on Protein: 676-697
Range on HMM: 192-214/270
Sequence Identity: 52% (12 aa)

TTTSDVYSFGVVLLELMS-GQKP
|| |||.||||.. |... |..|
TTKSDVWSFGVLMWEIFTYGEQP
Kinase IRAK-0_m-1.AA ABC1 510-529 38 0.000773 15.19 Pfam 22-42 (126) Show / Hide 
Range on Protein: 510-529
Range on HMM: 22-42/126
Sequence Identity: 38% (8 aa)

GSFATVYKGVLHN-GRQVAIK
.| | |....|.. |..||.|
ASIAQVHRARLKDDGEEVAVK
Kinase IRAK-0_m-1.AA LISK 741-765 32 0.003222 6.08 In-house 272-296 (296) Show / Hide 
Range on Protein: 741-765
Range on HMM: 272-296/296
Sequence Identity: 32% (8 aa)

VKLALECTKASGKERPSMSHVAKTL
..|...|.|   |.||| ... ..|
LDLCFDCCKYDPKNRPSFKEIVQWL
Kinase IRAK-0_m-1.AA Dicty4 679-697 57 0.004174 6.4 In-house 198-216 (277) Show / Hide 
Range on Protein: 679-697
Range on HMM: 198-216/277
Sequence Identity: 57% (11 aa)

SDVYSFGVVLLELMSGQKP
.|||||| || |.  .| |
ADVYSFGIVLWEILTRQEP
Kinase IRAK-0_m-1.AA LRRK 746-767 31 0.008271 5.75 In-house 330-351 (351) Show / Hide 
Range on Protein: 746-767
Range on HMM: 330-351/351
Sequence Identity: 31% (7 aa)

ECTKASGKERPSMSHVAKTLEE
.| ..  |.||..| . |.|..
HCWQHDPKKRPHFSQIVKRLSQ
Kinase IRAK-0_m-1.AA TK 743-765 26 0.030014 2.48 In-house 464-486 (486) Show / Hide 
Range on Protein: 743-765
Range on HMM: 464-486/486
Sequence Identity: 26% (6 aa)

LALECTKASGKERPSMSHVAKTL
| ..| ..  ..||..| . . |
LMQQCWHYDPEDRPTFSQLHEQL
Kinase IRAK-0_m-1.AA Dicty4 753-767 29 0.146771 1.17 In-house 261-277 (277) Show / Hide 
Range on Protein: 753-767
Range on HMM: 261-277/277
Sequence Identity: 29% (5 aa)

KERPSMSHVAKT--LEE
. |||.. . .   ||.
QHRPSFEEIIQRRILEH
Kinase IRAK-0_m-1.AA MLK 746-765 25 0.161819 1.19 In-house 272-291 (291) Show / Hide 
Range on Protein: 746-765
Range on HMM: 272-291/291
Sequence Identity: 25% (5 aa)

ECTKASGKERPSMSHVAKTL
.| ..  ..|||.... . |
QCWNQDPHKRPSFRQIVQHL
Kinase IRAK-0_m-1.AA Dicty4-Unclassified 742-765 29 0.182297 0.74 In-house 240-263 (263) Show / Hide 
Range on Protein: 742-765
Range on HMM: 240-263/263
Sequence Identity: 29% (7 aa)

KLALECTKASGKERPSMSHVAKTL
||   |   . . ||.|  . . |
KLIKWCWHNDPNKRPTMNQIIQYL