Gene IRAK-0_f (S.moellendorffii)

IRAK-0_f

Species: S.moellendorffii
Alias: IRAK-0_f
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-0

Sequence

Name Sequence Type Origin Length Description Download
IRAK-0_f.AA Protein None 826 None Fasta, JSON
IRAK-0_f.NA RNA None 2481 None Fasta, JSON
IRAK-0_f.kin_dom Protein Kinase Domain None 184 None Fasta, JSON

Protein domain

Protein domains of IRAK-0_f.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LRR_1 IRAK-0_f.AA LRR_1 10-23 35 34.522179 1.29 Pfam 11-26 (26) Show / Hide 
Range on Protein: 10-23
Range on HMM: 11-26/26
Sequence Identity: 35% (6 aa)

N--KLSGPLPSS-LGRL
|  .|.| .|.| .  |
NCCNLTGHIPPSCF-NL
LRR_1 IRAK-0_f.AA LRR_1 25-47 25 0.376545 8.25 Pfam 1-26 (26) Show / Hide 
Range on Protein: 25-47
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

NLVSIGFGS-N--DFSGTLPRE-IGNL
|| .. ... |   ..|..| . . ||
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-0_f.AA LRR_1 49-71 33 0.015128 13.2 Pfam 1-26 (26) Show / Hide 
Range on Protein: 49-71
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

SLRKIYMDAC---NLGGELPEE-FGNL
.|...... |   || |..|.. | ||
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-0_f.AA LRR_1 73-95 29 0.020528 12.73 Pfam 1-26 (26) Show / Hide 
Range on Protein: 73-95
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

SLETLWMAG-N--NFNGTFPEF-IGRL
.|..| . | |  |. |..|.  .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-0_f.AA LRR_1 121-142 33 0.02679 12.32 Pfam 1-26 (26) Show / Hide 
Range on Protein: 121-142
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

EINKLMLRNC---ELSGSIPD--LGNL
 . .| |..|    |.|.||.  . ||
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-0_f.AA LRR_1 144-166 51 3.8e-05 22.4 Pfam 1-26 (26) Show / Hide 
Range on Protein: 144-166
Range on HMM: 1-26/26
Sequence Identity: 51% (14 aa)

TLTHLDLSF-N--NLTGVIPSS-LWAF
.|.|||||  |  |||| ||.| . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-0_f.AA LRR_1 191-213 33 0.021763 12.64 Pfam 1-26 (26) Show / Hide 
Range on Protein: 191-213
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

SLQRLDVSF-N--ELSGPMPSW-ISRI
.||.||.|  |   |.|  |.. .   
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-0_f.AA LRR_1 168-190 33 0.13762 9.8 Pfam 1-26 (26) Show / Hide 
Range on Protein: 168-190
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

SLQNLLLGS-N--RLTGPLPSQ-LAST
.|| | |.. |  .||| .|.  . . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
Malectin IRAK-0_f.AA Malectin 252-414 35 5e-43 154.07 Pfam 1-179 (202) Show / Hide 
Range on Protein: 252-414
Range on HMM: 1-179/202
Sequence Identity: 35% (64 aa)

YQFAINCGGPQI--TSSSGTMFSEDTAMFTMGT----FTSNDQAWVVGSTGYSDGFVRA----FENTTVPVLGTVDR---GLYQTSRSAPSSLRYIGLGM
| ..|||||| .  |.|.|...  |..    ..    . | .. | . .  ..|    .    .  |......| |     |||| | .|||.|| ....
YSWHINCGGPEHYTTDSDGITYEADNHFTGGSAASDYYVSRNNWWGYSTGDFMDDDNNQYYYGYITTNSSIFYTTDDVDPELYQTERWSPSSFRYYIPCL

VNGAYTLEFHFAEIQLDN-STTWLGITRRLFDIYLQGTQRVKDFNIQNEAGGSSRALVRTFRNVQVTNNVLD--MHFVW
 || ||.. |||||.  . . || .  || ||.|.||   .|||.|  ||||...| .. | || |||..|.   || |
ENGNYTVILHFAEIYFQDTDQTWNSPGRRVFDVYIQGKLVLKDFDIWKEAGGKGKAAHKEFINVTVTNGTLEYVIHFYW
Kinase IRAK-0_f.AA TKL 501-749 20 1.9e-59 203.8 In-house 1-364 (364) Show / Hide 
Range on Protein: 501-749
Range on HMM: 1-364/364
Sequence Identity: 20% (77 aa)

LGQGGFGAVYKGVLPS---------GTVVAIKELSSKS--------------------------QQGSREFLNEVTLISS-VQHRNLVKLHGCCIDGDH-
.|.|||| ||||..           |..||.| ..|..                          ..  |.|..|.... |  .| |.|.. |.|..... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------RLLVYEFLENNSLHHVLL------ICLGIARGLSYLHEDS-----KPKIVHRDIKAHNVLLDRNMT--------------PKIADFGL
              .|.|. .. ||.|.|.      ..|.||||..||| .      ||.|.|||.| .|.|.|.|.|              .||.||||
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLHWHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGL

AKLFQDHETHVSTR------------------VAGTIGYLSPEYAM----------------RGQLTEKADVYSFGVLALEIVSGRSNLDTSVPADMVYL
.. .. ..    |                   . ||.....||  .                 .. .||.||||||..  ||....       | .    
SRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR------PYYDYPY

LEWAWN----LYERKQEMDMVDKELTDVSQE---------EAARVIKVALLCSQAVASSRPAMSHVVAML
 .. ..    ..  .   .    .. .. |.            ...| .  | .. ...|| .. ..  |
MPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAK-0_f.AA TK 495-676 17 6.3e-45 148.09 In-house 1-389 (486) Show / Hide 
Range on Protein: 495-676
Range on HMM: 1-389/486
Sequence Identity: 17% (69 aa)

FSSENKLGQGGFG---AVYKGVLPSG--------------------------TVVAIKELSSKSQQGSRE--------------FLNEVTLISSVQ----
   ..|||.| ||    |||| . ..                          | ||.| | ... . ..|              ||.|.  ..  .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HRNLVKLHGCCIDG------------DHRLLVYEFLENNS----LHHVLL-------------------------------------------------
 | |.|.|.|.| .|             . ..| |. .. .    |.. |                                                  
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

--------------------------------------ICLGIARGLSYLHED----SKPKIVHRDIKAHNVLLDRNMT-----------PKIADFG---
                                      .|. ||.|..|||.       ...||||. |.|.|...|..            ||||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LAKLFQDHETHVSTRVAGTIG-------------------------YLSPEYAM---------RGQLTEKADVYSFGVLALEIVS
     ||.  ....  ....  || .                         ...||  .          |  |.| ||.|||||  ||..
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFT
Pkinase IRAK-0_f.AA Pkinase 495-678 28 1.9e-43 154.73 Pfam 1-209 (293) Show / Hide 
Range on Protein: 495-678
Range on HMM: 1-209/293
Sequence Identity: 28% (61 aa)

FSSENKLGQGGFGAVYKGVLPSGTV-VAIKELSSKSQQGSRE--FLN--EVTLISSVQHRNLVKLHGCCIDGDHRLLVYEFLENN----SLH-------H
.  . |.|.|.|| |||..  .    ||.|... ...  . .   ..  |. .  ...| | |.|.... |.||  .| |..|.     .|.       |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

VLL---------ICLGIARGLSYLHEDSKPKIVHRDIKAHNVLLDRNMTP----KIADFGLAKLFQDHETHVSTRVAGTIGYLSPEYAM-RGQLTEKADV
  .         ... |.||| |.|.    .|.|||.|  |.|.|.|...    ||.||||||.|.    .  | ..||..|..||  . .   . |.|.
GCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

YSFGVLALEIVSGR
.|.|..  | ..||
WSCGCILYEMLCGR
Kinase IRAK-0_f.AA MLK 495-678 26 1.5e-42 145.42 In-house 1-233 (291) Show / Hide 
Range on Protein: 495-678
Range on HMM: 1-233/291
Sequence Identity: 26% (62 aa)

FSSENKLGQGGFGAVYKGVLPSGT----VVAIKELS----SKSQQG--SREFLNEVTLISSVQHRN----LVKLHGCCID-GDHRLLVYEFLENNSLHHV
.  . ..| |.||.|.||.    .    .||.|.      .||. .  ...|  |. . . ..|.|     ... |.|.. . | ..| |..|. ||..|
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

L--------------------------LICLGIARGLSYLHEDSKPKIVHRDIKAHNVLLDR------NMTPKIADFGLAKLFQDH-ETHVSTRVAGTIG
|                           ..| .|||..|||.. ...|.|||.| ||.|.|.      ..| ||.|||... .... ... |.  |||  
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSN--AGTYA

YLSPEY---AMRGQLTEKADVYSFGVLALEIVSGR
. .||    .  .. .||.||.|.||.  |.....
WMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTRE
Kinase IRAK-0_f.AA STE 495-678 21 1.7e-38 133.61 In-house 1-265 (359) Show / Hide 
Range on Protein: 495-678
Range on HMM: 1-265/359
Sequence Identity: 21% (59 aa)

FSSENKLGQGGFGAVYKGVLP----------------SGTVVAIKELSSKSQQG-----------------SREFLNEVTLISSVQ--HRNLVKLHGCCI
.    |.|.|.|| |||..                  .|...|||... ....                    ..|.|. . .  .  | | || .||..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DG-------DHRLLVYEFLENNSLHHVLL--------------------------ICLGIARG-LSYLHEDSKPKIVHRDIKAHNVLLDRNMTPKIADFG
..       |.  .. |.... ||  ..                           ||  | .| |.|||.     |.|||||. |.||      |..|||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDFG

LAKLFQDH-------------ETHVSTR--VAGTIGYLSPEYAMR------GQLTEKADVYSFGVLALEIVSGR
... ..|.             || .. |  ..||  . .||  ..      .. ..|.|..|.| ...| . |.
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK
Kinase IRAK-0_f.AA S_TKc 495-776 21 2.4e-36 127.99 SMART 1-231 (231) Show / Hide 
Range on Protein: 495-776
Range on HMM: 1-231/231
Sequence Identity: 21% (65 aa)

FSSENKLGQGGFGAVYKGVLPS-GTVVAIKELSSKSQQGSREFLNEVTLISSVQHRNLVKLHGCCIDGDHRLLVYEFLEN--NSLHHVLL----------
.   .|.|.|.|| |||..  . | .||||...       . ...|. . .. .| |.|||.... | ||  .| |....   .|....           
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

-------ICLGIARGLSYLHEDSKPKIVHRDIKAHNVLLDRNMTPKIADFGLAKLFQDHETHVSTRVAGTIGYLSPEYAMRGQLTE-KADVYSFGVLALE
       ..  |...| |.|  |. .|.|||.|  |.|||.  . ||.|||||...        | . ||  |..||     . .  |.|..|.|..  |
FPEHARFYMYQICCALEYCH--SH-GIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

IVSGRSNLDTSVPADMVYLLEWAWNLYERKQEMDMVDKELTDVSQEEAARVIKVALLCSQAVASSRPAMSHVVAMLVGTSPVDVSSLRPGYFSALK----
 ..|.   .   .. |  ..                                                 |. .  ..    .   . ||.   ||.    
MLCGYPPFP--QMQMMFKKIG------------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWD

DAAPGFF
 ..  .|
IKCHPWF
Kinase IRAK-0_f.AA TKL-Unique 499-669 31 1.4e-35 122.99 In-house 3-216 (290) Show / Hide 
Range on Protein: 499-669
Range on HMM: 3-216/290
Sequence Identity: 31% (67 aa)

NKLGQGGFGAVYKGVLPSGTVVAIKELSS---KSQQGSREFLNEVTLISSVQ-HRNLVKLHGCCI----DGDHRLLVYEFLENNSLHHVLL---------
||.|.||.|.||||. . |. |||| ..    .| . ..|| |||....  . | |.|.. | |.    .  .. .| |... .||. ||          
NKIGEGGYGQVYKGKWR-GYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNN

-------------ICLGIARGLSYLHEDSKPKIVHRDIKAHNVLLDRN-----MTPKIADFGLAKLFQ-DHETHVS-------TRVAGTIGYLSPEYAMR
             . . ||.|. |||  ..| | |||.|  |.|.|.|     .  ||.||||.|.   . .. ..       . . |.. ...||  ..
NNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRM

--GQLTEKADVYSFGV
   | .||.||||||.
NFCQYSEKSDVYSFGI
Kinase IRAK-0_f.AA Ciliate-E2 495-678 18 6e-35 117.4 In-house 1-293 (365) Show / Hide 
Range on Protein: 495-678
Range on HMM: 1-293/365
Sequence Identity: 18% (56 aa)

FSSENKLGQGGFGAVYKG--VLPSG-------------------TVVAIKELSSKSQQGSREFLNEVTLI----------------SSVQHRNLVKLHGC
.   .|.|||.|| |||.   .                      . . |... ...... .....|  ..                ....| |..|.. |
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

CI--DGDHRLLVYEFLENNSLHH-----------------------VLLICLGIAR---------------GLSYLHEDSKPKIVHRDIKAHNVLLDRNM
 .  | ..  || |... ..| .                       .. |   |..               .| |||.  .  |.|||||  |.|.    
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN--IIHRDIKPENILF----

TPKIADFGLAKLFQDH-----------------ETHVSTR-------------VAGTIGYLSPEYAMRGQ---------LTEKADVYSFGVLALEIVSGR
 .||.||||.| ..|                  .|.....             ..|| ||..||  ....          ..|.|..|.||.  | ..|.
-IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK
Kinase IRAK-0_f.AA IRAK 582-749 28 4.8e-34 118.09 In-house 114-317 (317) Show / Hide 
Range on Protein: 582-749
Range on HMM: 114-317/317
Sequence Identity: 28% (58 aa)

ICLGIARGLSYLHEDS-KPKIVHRDIKAHNVLLDRNMTPKIADFGLAKLF---QDHETHVS-----TRVAGTIGYLSPEYAM--RGQLTEKADVYSFGVL
||.|.|.|. .||... .  | |.|||  |.||| ..||||.||||.      .. | ...      .| ||  |. ||.     |||| | ||||||. 
ICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQLTKKTDVYSFGIV

ALEIVSGRSNLDTSVPADMVYLLEWAWNLYERKQE--------------------MDM------VDKELTDVSQEEAARVIKVALLCSQAVASSRPAMSH
 ||...|.   .. .|    ||..   .. |                          |      .|.  ...  ....    .|. |  . |  |..|  
LLEVLTGCRAVYDDRPE-HYYLKDLCEEIMEEWGHLDSCQSTLWVGVATDAWAAPRRMQIYEKFIDHRMPPCPPNMEKEMCQCACCCGHHRANRRCDMAW

VVAML
|.. |
VMQQL
Kinase IRAK-0_f.AA LRRK 495-678 24 8e-32 109.85 In-house 1-279 (351) Show / Hide 
Range on Protein: 495-678
Range on HMM: 1-279/351
Sequence Identity: 24% (69 aa)

FSSENKLGQGGFG-AVYKGVLPS---------------------------GTVVAIKELSSK---SQQGS------------------------------
. .|...|.||||  ||.. . .                           .. |||| .      .   .                              
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTID-NDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCR

--REFLNEVTLISSVQHRNLVKLHGCCIDGDHRLLVYEFLENNSLHHVLL---------------------ICLGIARGLSYLHEDSKPKIVHRDIKAHN
  ||| .||...|. .| |.|.| | ||  ... .| |.. . .|.|.|                      | | ||.|. ||| ...|.|.||| | .|
AFREFRHEVWIMSHLNHPNIVSLKGFCI--HPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLH-SHNPPIIHRDLKSPN

VLL---D---------RNMTPKIADFGLAKLFQDHETHVSTRVAGTIGYLSPEYAMRG---QLTEKADVYSFGVLALEIVSGR
.||   .          ... ||||||.  .||   . |  .. |..|...||    .   . |||.|.||||..  |.....
ILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQ
Kinase IRAK-0_f.AA TyrKc 495-749 23 1.8e-31 111.76 SMART 1-280 (280) Show / Hide 
Range on Protein: 495-749
Range on HMM: 1-280/280
Sequence Identity: 23% (70 aa)

FSSENKLGQGGFGAVYKGVLPSGTVVAIKELSSKSQQGSREFLNEVTLISSV--QHRNLVKLHGCCIDG-------DHRLLVYEFLENNSLHHVL-----
 . . ||| | || ||||..   . ||.| | . .    ..|..|  . ...  .| |.|.|.|.|...       .  ..| |. .. .|.. |     
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

--------LICLGIARGLSYLHEDSKPKIVHRDIKAHNVLLDRNMTPKIADFGLAKLFQDH--------ETHV----STRVAGTIGYLSPEYAMRGQLTE
         .|. ||.| .|||.    ...|||. | |.|...| | ||.||||..   |.          ..    ...    |  ..||  . |  |.
KLCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

KADVYSFGVLALEIVSGRSNLDTSV---PADMVYLLEWAWNLYERKQEMD---MVDKELTDVSQEEAARVIKVALLCSQAVASSRPAMSHVVAML
| ||.||||.  || .        .   . .   ..|.  . | ..|  .   |        . .  . . .. . | .. ...|| .| ..  .
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-------FVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase IRAK-0_f.AA Dicty4 580-668 41 5e-30 97.46 In-house 115-204 (277) Show / Hide 
Range on Protein: 580-668
Range on HMM: 115-204/277
Sequence Identity: 41% (38 aa)

LLICLGIARGLSYLHEDSKPKIVHRDIKAHNVLLDRNMTPKIADFGLAKLFQDHETHVS--TRVAGTIGYLSPEYAMRGQLTEKADVYSFG
..... .|||. .||. . | |.|||.|.|| | | |.. |..||||..... ||.|    . ..|| .. .||  |    .|||||||||
MRMAFDAARGMNWLHC-CNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADVYSFG
Kinase IRAK-0_f.AA TK-Unique 582-676 36 1.2e-23 78.55 In-house 136-234 (294) Show / Hide 
Range on Protein: 582-676
Range on HMM: 136-234/294
Sequence Identity: 36% (37 aa)

ICLGIARGLSYLHE--DSKPKIVHRDIKAHNVLLDRNMTPKIADFGLAKLFQDHETHVSTR--VAGTIGYLSPEYAM--RGQL-TEKADVYSFGVLALEI
.. .||.|..||..  .   ||||||. |.|||| .. . ||.|||.|.  .... .....      | ...||.    .|.  |.| ||.|||||  ||
FAWQIACGMEYLASQRK---KIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEI

VS
..
FT
Kinase IRAK-0_f.AA Pkinase_Tyr 495-578 27 6e-21 71.57 Pfam 1-96 (270) Show / Hide 
Range on Protein: 495-578
Range on HMM: 1-96/270
Sequence Identity: 27% (26 aa)

FSSENKLGQGGFGAVYKGVLP-----SGTVVAIKELSSKSQQG---SREFLNEVTLISSV-QHRNLVKLHGCCI-DGDH--RLLVYEFLENNSLHH
 .   |||.| || ||||..       .. ||.| |  .. .    ...|..|. . ..  .| |.|.|.|.|. .|..   ..| |. .. .|..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLD
Kinase IRAK-0_f.AA IRAK 495-577 29 3.1e-18 61.36 In-house 1-91 (317) Show / Hide 
Range on Protein: 495-577
Range on HMM: 1-91/317
Sequence Identity: 29% (27 aa)

FSSENKLGQGGFGAVYKGVLPSGT-VVAIK----ELSSKSQQGSREFLN---EVTLISSVQHRNLVKLHGCCIDGDHRLLVYEFLENNSLH
|. .|..|.|||| ||.|..   | ..|.|    . ...  .  ..|.    |. . .. .| |.| | | |....   |||... | ||.
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLE
Kinase IRAK-0_f.AA TK-Unique 495-580 25 2.9e-16 52.71 In-house 1-96 (294) Show / Hide 
Range on Protein: 495-580
Range on HMM: 1-96/294
Sequence Identity: 25% (24 aa)

FSSENKLGQGGFGAVYKGVLPSGT-------VVAIKELS-SKSQQGSREFLNEVTLISSVQ-HRNLVKLHGCCIDGD-HRLLVYEFLENNSLHHVL
.  ....|.| || |..| . ...       .||.| |  . ...  ..||.|  . ...  | |.|.. |||.. |   ....|.... .| | |
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYL
Kinase IRAK-0_f.AA Pkinase_Tyr 580-670 36 3e-14 48.88 Pfam 114-203 (270) Show / Hide 
Range on Protein: 580-670
Range on HMM: 114-203/270
Sequence Identity: 36% (34 aa)

LLICLGIARGLSYLHEDSKPKIVHRDIKAHNVLLDRNMTPKIADFGLAKLFQDHETH-VSTRVAGT-IGYLSPEYAMRGQLTEKADVYSFGVL
| .|. ||.|..||..     ..|||. | |.|...|.. ||.|||||.. .. ..  ...  .   |  ..||  . |  |.| ||.|||||
LQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVL
Kinase IRAK-0_f.AA Dicty4 495-559 32 7.1e-09 25.92 In-house 1-68 (277) Show / Hide 
Range on Protein: 495-559
Range on HMM: 1-68/277
Sequence Identity: 32% (23 aa)

FSSENKLGQGGFGAVYKGVLPSGTVVAIKELSSKSQQGS-----REFLNEVTLISSVQHRNLVKLHGCCI
   |...|.|.|| ||||    |. ||.| | .. .|..      ||..||.. .. .| |.... | |.
INIEQRIGKGSFGEVYKGTW-RGKEVAVKKLNNH-NQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACT