Gene IRAK-0_ar-2 (S.moellendorffii)

IRAK-0_ar-2

Species: S.moellendorffii
Alias: IRAK-0_ar-2
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-0

Sequence

Name Sequence Type Origin Length Description Download
IRAK-0_ar-2.AA Protein None 565 None Fasta, JSON
IRAK-0_ar-2.NA RNA None 1698 None Fasta, JSON
IRAK-0_ar-2.kin_dom Protein Kinase Domain None 201 None Fasta, JSON

Protein domain

Protein domains of IRAK-0_ar-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
DUF26 IRAK-0_ar-2.AA DUF26 103-148 22 5.2e-05 17.21 Pfam 12-55 (55) Show / Hide 
Range on Protein: 103-148
Range on HMM: 12-55/55
Sequence Identity: 22% (11 aa)

DQPSCGQCIQNAYTNI-QSVNLYAVGGAIWINQTFQRCRMRYDPSS-F
.  .| .|.. |  .. ..   ...||.||      .| .||. .. |
SPSDCRDCLATAVRQMLPQCCPNRQGGRIW----YDWCYLRYSDYPNF
Kinase IRAK-0_ar-2.AA TKL 260-526 21 4.4e-69 235.81 In-house 1-364 (364) Show / Hide 
Range on Protein: 260-526
Range on HMM: 1-364/364
Sequence Identity: 21% (80 aa)

LGQGGFGTVYKATLNN---------GSQVAVKKLSLQSNQGN---------------------------REFVNEITIITGIQHRNLVRLKGYCVEADE-
.|.||||.|||.....         |  |||||.. .... .                            ....|| ..  ..| |.|...||| . .  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------RLLVYEFLNKGS-LDRALFSSGSNVVLDWHSRFQIAIGIARGLAYLHEESH-----VQIIHRDIKASNILLDDKLQ------------
              .|.|.  .|| |.. .          || |...|..||||..||| .        .|||||.| .|||.|....            
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD

--PKISDFGISKLFDLDKGFGFTSTK----------------VAGTLGYMAPEYAT----------------RGRLTTKADVFSYGILVLEIASGRKCVD
  .||.|||.|. .. ...   |.|.                . ||...||||                    .  ..|.||.|.||.  ||.....   
WCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR---

PAL-PAEEELLLQ----LSWKLVMANRMSECIDKRLGG----DYAVDEVSRLLRVAMLCTQEHEEARPTMSDVVAML
|   . ... ..|    . ...|  ...   |. .           |   .. . .. | ..  |.||......  |
PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAK-0_ar-2.AA IRAK 254-458 35 5.6e-64 218.86 In-house 1-225 (317) Show / Hide 
Range on Protein: 254-458
Range on HMM: 1-225/317
Sequence Identity: 35% (80 aa)

FSVESKLGQGGFGTVYKATLNNGS-QVAVKKL----SLQSNQGNREFVN---EITIITGIQHRNLVRLKGYCVEADERLLVYEFLNKGSLDRALFSSGSN
|... ..|.||||.||.. ..|    .|||||    ... |.  ..|     |. . . ..| |.| | ||| | ..  |||...  |||   |   .  
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

VV---LDWHSRFQIAIGIARGLAYLHEES-HVQIIHRDIKASNILLDDKLQPKISDFGISKLF----DLDKGFG--FTSTKVAGTLGYMAPEYAT--RGR
.    | || |. |..|.|.|. .||. .  . |||.||| .|||||. ..|||.|||         .. |.    .   .| ||. ||.||. .   |.
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQ

LTTKADVFSYGILVLEIASGRKCVD
||.| ||.| || .||...|.. |.
LTKKTDVYSFGIVLLEVLTGCRAVY
Kinase IRAK-0_ar-2.AA Pkinase 254-454 29 2.2e-51 181.83 Pfam 1-209 (293) Show / Hide 
Range on Protein: 254-454
Range on HMM: 1-209/293
Sequence Identity: 29% (65 aa)

FSVESKLGQGGFGTVYKATLNNGSQ-VAVKKLSLQSNQG--NREFVN--EITIITGIQHRNLVRLKGYCVEADERLLVYEFLNKG----SLDRALF--SS
. ...|.|.|.||.|||..  . .. ||||.......    ... ..  || |   ..| | |||.... . |.  .| |....|    .| . .   ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GSNVVLDWHSRFQIAIGIARGLAYLHEESHVQIIHRDIKASNILLDDKLQP----KISDFGISKLFDLDKGFGFTSTKVAGTLGYMAPEYAT-RGRLTTK
|.   ....    ..  |.|||.|.|..    |||||.| .|||.|.. ..    ||.|||..|.||     .   | ..||..|||||    .   ..|
GCFY-FSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

ADVFSYGILVLEIASGR
.|..|.|... | ..||
VDMWSCGCILYEMLCGR
Kinase IRAK-0_ar-2.AA Dicty4 254-451 33 3.3e-47 155.57 In-house 1-211 (277) Show / Hide 
Range on Protein: 254-451
Range on HMM: 1-211/277
Sequence Identity: 33% (72 aa)

FSVESKLGQGGFGTVYKATLNNGSQVAVKKL-SLQSN-QGNR--EFVNEITIITGIQHRNLVRLKGYCV----EADERLLVYEFLNKGSLDRALFS----
  .|...|.|.||.|||.|   |..|||||| ... |   |.  || .|..|   |.| |.. ..|.|     .  . . | |.. ||.| . | .    
INIEQRIGKGSFGEVYKGTW-RGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSE

SGSNVVLDWHSRFQ---IAIGIARGLAYLHEESHVQIIHRDIKASNILLDDKLQPKISDFGISKLFDLDKGFGF-TSTKVAGTLGYMAPEYATRGRLTTK
  ... |||  . .   .|. .|||...||. . . |||||.|..|.| |. .. |..|||.|...  .. ... ..| ..|| ..||||     . . |
QQQSIKLDWPLIKRAMRMAFDAARGMNWLHC-CNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMT-ACGTPCWMAPEVMMHQPYNEK

ADVFSYGILVLEIA
|||.|.||.  ||.
ADVYSFGIVLWEIL
Kinase IRAK-0_ar-2.AA MLK 254-454 26 1.2e-43 149.34 In-house 1-233 (291) Show / Hide 
Range on Protein: 254-454
Range on HMM: 1-233/291
Sequence Identity: 26% (62 aa)

FSVESKLGQGGFGTVYKATLNNGS----QVAVKKLSL------QSNQGNREFVNEITIITGIQHRN----LVRLKGYCVEADE-RLLVYEFLNKGSLDRA
. .. ..| |.|| |.|..  |       ||||.         ..    ..|  |. .   ..|.|     ....| | .     ..| |.. .||| . 
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LFS-SG----------SNVVLDWHSRFQIAIGIARGLAYLHEESHVQIIHRDIKASNILLDD------KLQPKISDFGISKLFDLDKGFGFTSTKVAGTL
| . ..          . .| | .. ...|  .|||..|||..  ..|||||.| .|||.|.      ... ||.|||.|  .|. .    . .. |||.
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTS--RDWHQMC-TNMMSNAGTY

GYMAPEY---ATRGRLTTKADVFSYGILVLEIASGR
 .||||    .  .. . |.||.|.|..  |. ...
AWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTRE
Kinase IRAK-0_ar-2.AA TKL-Unique 256-453 32 1.5e-43 150.99 In-house 1-224 (290) Show / Hide 
Range on Protein: 256-453
Range on HMM: 1-224/290
Sequence Identity: 32% (73 aa)

VESKLGQGGFGTVYKATLNNGSQVAVKKLSL---QSNQGNREFVNEITIITGIQ-HRNLVRLKGYCV----EADERLLVYEFLNKGSLDRALF----SS-
. .|.|.||.|.|||..  .|..||.|....   .||.  .|| ||....  .. | |.|.. |||.     . .. .| |... |||.  |      . 
FWNKIGEGGYGQVYKGKW-RGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

--GSNVVLDWHSRFQIAIGIARGLAYLHEESHVQIIHRDIKASNILLDDK-----LQPKISDFGISKLFD-LDKGFGFTS-----TKVAGTLGYMAPEYA
   .|  |..  | ..|| ||.|. ||| ..   |||||.| ||.|.| .     .. ||.|||.||. .  .|..  ..     . . |.. .||||  
NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVL

TR--GRLTTKADVFSYGILVLEIASG
..     ..|.||.|.|| . |||..
RMNFCQYSEKSDVYSFGIVLWEIATR
Kinase IRAK-0_ar-2.AA TK 254-452 16 5e-43 141.61 In-house 1-389 (486) Show / Hide 
Range on Protein: 254-452
Range on HMM: 1-389/486
Sequence Identity: 16% (66 aa)

FSVESKLGQGGFG---TVYKATLNNGS--------------------------QVAVKKLSLQSNQGNRE-----------------FVNEITIITG--I
  .. |||.| ||   .|||.......                          .|||| | . ...  .|                 ...|. .      
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

QHRNLVRLKGYCVEADE------------RLLVYEFLNKGS----LDRALFSSGSNVV------------------------------------------
.| |.||| |.|.. ..             ..| |. ..|.    |.  | ..  .                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LDWHSRFQIAIGIARGLAYLHEE--SHV--QIIHRDIKASNILLDDKLQ-----------PKISDFGIS
                               |. | .  ..  ||.|..|||.   .    ...|||. | |.|......            ||.||| |
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

------KLFDLDKGFGFTSTKVAGTLG-------------------------YMAPEYAT---------RGRLTTKADVFSYGILVLEIAS
         |....   ....  || .                         .||||  .          |. ||| ||.|.|.|. || .
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFT
Kinase IRAK-0_ar-2.AA STE 254-454 23 3.3e-41 143.24 In-house 1-265 (359) Show / Hide 
Range on Protein: 254-454
Range on HMM: 1-265/359
Sequence Identity: 23% (65 aa)

FSVESKLGQGGFGTVYKATLNN----------------GSQVAVKKLSLQSNQG-----------------NREFVNEITIITGIQ--HRNLVRLKGYCV
.   .|.|.|.|||||||  ..                |  .|.|...|....                    .. .|| |    .  | | |.  |...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

EA-------DERLLVYEFLNKGSLDRALF---SSGSN--------VVLDWHSRFQIAIGIARG-LAYLHEESHVQIIHRDIKASNILLDDKLQPKISDFG
         ||  .. |... ||||  .    . | .         ... .    |.  | .| |.|||.     |||||||..||||      |..|||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDFG

ISKLFDLDKG-------------FGFTSTKVAGTLGYMAPEYATRGR------LTTKADVFSYGILVLEIASGR
... .. .                .  .. ..||  .||||  ....       .||.|. | |....| | |.
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK
Kinase IRAK-0_ar-2.AA S_TKc 254-530 24 4.9e-39 136.91 SMART 1-231 (231) Show / Hide 
Range on Protein: 254-530
Range on HMM: 1-231/231
Sequence Identity: 24% (70 aa)

FSVESKLGQGGFGTVYKATLNN-GSQVAVKKLSLQSNQGNREFVNEITIITGIQHRNLVRLKGYCVEADERLLVYEFLNK--GSLDRALFSSGSNV----
. .  |.|.|.||.|||.. .. | .||.|...       . . .|| |    .| |.|.|...... |.  .| |...   |.| . . . |..     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

VLDWHSRFQIAIGIARGLAYLHEESHVQIIHRDIKASNILLDDKLQPKISDFGISKLFDLDKGFGFTSTKVAGTLGYMAPEYATRGRLTT-KADVFSYGI
    | || ..  |...|.|.|  || .|||||.| .|||||.  . ||.|||.....          | . ||. |||||       .. |.|. | |.
FPE-HARF-YMYQICCALEYCH--SH-GIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGC

LVLEIASGRKCVDPALPAEEELLLQLSWKLVMANRMSECIDKRLGGDYAVDEVSRLLRVAMLCTQEHEEARPTMSDVVA-----MLLGYL
.. | ..|.   .     ........                           . ..   . | |   | |||  .. .     ..  ..
ILYEMLCGYPPFP-----QMQMMFKKIG------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAK-0_ar-2.AA LRRK 254-454 25 3.3e-38 132.75 In-house 1-279 (351) Show / Hide 
Range on Protein: 254-454
Range on HMM: 1-279/351
Sequence Identity: 25% (74 aa)

FSVESKLGQGGFG-TVYKATLNN---------------------------GSQVAVKKLSLQS--------NQGN-------------------------
.  |...|.|||| .||.|....                           .. ||.||. . .        |  |                         
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

-REFVNEITIITGIQHRNLVRLKGYCVEADERLLVYEFLNKGSLDRALFSSGSNV------VLDWHSRFQIAIGIARGLAYLHEESHV-QIIHRDIKASN
 ||| .|..|. . .| |.| |||.| .   . .| |..  |.|.. |... ..       ...|. . .||. ||.|..|||  ||   ||||| |  |
FREFRHEVWIMSHLNHPNIVSLKGFCIHP--LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLH--SHNPPIIHRDLKSPN

ILL---D---------DKLQPKISDFGISKLFDLDKGFGFT-STKVAGTLGYMAPEYATRG---RLTTKADVFSYGILVLEIASGR
|||   .         .    ||.||||| .|   . |. .   .. |. |.||||    .     |.|.|..|.|..  |. ...
ILLWSSPQNHSPNYPNAHVCAKIADFGISRMF---QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQ
Kinase IRAK-0_ar-2.AA Dicty4-Unclassified 254-453 33 7.1e-38 127.28 In-house 1-204 (263) Show / Hide 
Range on Protein: 254-453
Range on HMM: 1-204/263
Sequence Identity: 33% (71 aa)

FSVESKLGQGGFGTVYKATLNNGSQVAVKKLSLQSNQGN----REFVNEITIITGIQHRNLVRLKGYCVEA----DERLLVYEFLNKGSLDRALF--SSG
  .   .|.| |  |.|     |  |||||.   . .       .|  |. |   ||| |||...|||.           | ||. || |        | 
IQIDQFIGKGHFSKVHKGNW-KGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSE

SNVVLDWHS--RFQIAIGIARGLAYLHEESHVQIIHRDIKASNILLDDKLQPKISDFGISKLFDLDKGFGFTSTKVAGTLGYMAPEYATRGRLTTKADVF
 .  .   .     .|. ||.|...||    . .||||||.||||.|     || |||||   |    | |. | .|||    .||       . |.||.
QQQPIKLDDTLIIKYAFDIAQGMQHLHT---RNFIHRDIKSSNILMDKHFNIKIADFGISRVID----FNFNMTTIAGTPKWESPECLMHESYNQKSDVY

SYGILVLEIASG
||...  | | |
SYAMMLYELATG
Kinase IRAK-0_ar-2.AA TyrKc 254-526 26 5.3e-37 130.16 SMART 1-280 (280) Show / Hide 
Range on Protein: 254-526
Range on HMM: 1-280/280
Sequence Identity: 26% (80 aa)

FSVESKLGQGGFGTVYKATLNNGSQVAVKKLSLQSNQGNREFVNEITIITGI--QHRNLVRLKGYCVEA-------DERLLVYEFLNKGSLDRALFSSGS
 . . ||| | ||.|||.|..   |||||.|   .    ..| .|. | . .  .| |.||| |.|..        .  ..| |.  .|.|.  | ... 
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

NVVLDWHSRFQIAIGIARGLAYLHEESHVQIIHRDIKASNILLDDKLQPKISDFGISKLFDLD------KGFGFT----STKVAGTLGYMAPEYATRGRL
.  | .    .... ||.| .|||.    ..||||. | |.|...... |||||| |.  . |      |    .    ..|    .  ||||    |. 
K--LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

TTKADVFSYGILVLEIASGRKCVDPALPAEEE----LLLQLSWKLVMANRMSECIDK-----RLGGDYAVDEVSRLLRVAMLCTQEHEEARPTMSDVVAM
||| ||.|.|..  || .     . . | ...    .  |   ..|.. .. .. .             |   . . ..   | .|  | |||.|...  
TTKSDVWSFGVCMWEIFT-----YGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF------VCCPDEMYQIMKQCWHEDPEDRPTFSEIHEC

L
.
F
Kinase IRAK-0_ar-2.AA TK-Unique 254-452 24 2.3e-35 119.44 In-house 1-234 (294) Show / Hide 
Range on Protein: 254-452
Range on HMM: 1-234/294
Sequence Identity: 24% (58 aa)

FSVESKLGQGGFGTVYKATLNNGS-------QVAVKKLSLQSNQG-NREFVNEITIITGIQ-HRNLVRLKGYCVEAD-ERLLVYEFLNKGSLDRALFSSG
. |....|.| ||.|..... ...       .||||.|   ...   ..| .|| .   .  | |.|.. |.|.. |   ....|.. .|.|.  | ...
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

SN-----------------------VVLDWHSRFQIAIGIARGLAYLHE--ESHVQIIHRDIKASNILLDDKLQPKISDFGISKLFDLDKGFGFTSTKVA
 .                         .. .. ...|..||.|..||..  .   .|.|||. |.|.|| .... ||.|||...  . ..    . ..  
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRK---KIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGR

GTLGYMAPEYAT--RGRL-TTKADVFSYGILVLEIAS
  . .||||.    .|   ||| || |.|.|  ||..
IPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFT
Kinase IRAK-0_ar-2.AA Pkinase_Tyr 254-403 30 1.2e-33 114.56 Pfam 1-160 (270) Show / Hide 
Range on Protein: 254-403
Range on HMM: 1-160/270
Sequence Identity: 30% (49 aa)

FSVESKLGQGGFGTVYKATLN-----NGSQVAVKKLSLQSNQGN---REFVNEITIITGI-QHRNLVRLKGYCV-EADE--RLLVYEFLNKGSLDRALFS
 .   |||.| ||.|||.|..     .. .||||.|  .. . .   ..| .|. | . . .| |.||| | |. . .    ..| |.  .|.|.  | .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

S-GSNVVLDWHSRFQIAIGIARGLAYLHEESHVQIIHRDIKASNILLDDKLQPKISDFGISKL
   ..  |. .   |... ||.|..||..     .||||. | |.|...... ||.||| ...
HREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARD
Kinase IRAK-0_ar-2.AA Pkinase_Tyr 424-455 48 0.00012 16.36 Pfam 181-213 (270) Show / Hide 
Range on Protein: 424-455
Range on HMM: 181-213/270
Sequence Identity: 48% (16 aa)

MAPEYATRGRLTTKADVFSYGILVLEIAS-GRK
||||    |. ||| || |.|.|  || . |..
MAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQ
Kinase IRAK-0_ar-2.AA TK 503-526 29 0.000399 8.88 In-house 463-486 (486) Show / Hide 
Range on Protein: 503-526
Range on HMM: 463-486/486
Sequence Identity: 29% (7 aa)

RVAMLCTQEHEEARPTMSDVVAML
.. . | ..  | |||.|... .|
DLMQQCWHYDPEDRPTFSQLHEQL
Kinase IRAK-0_ar-2.AA TK-Unique 508-526 31 0.001795 7.98 In-house 276-294 (294) Show / Hide 
Range on Protein: 508-526
Range on HMM: 276-294/294
Sequence Identity: 31% (6 aa)

CTQEHEEARPTMSDVVAML
|.|. .| ||. .... .|
CWQWEPEERPSFRQIKHRL
Kinase IRAK-0_ar-2.AA LRRK 506-528 30 0.17657 0.98 In-house 329-351 (351) Show / Hide 
Range on Protein: 506-528
Range on HMM: 329-351/351
Sequence Identity: 30% (7 aa)

MLCTQEHEEARPTMSDVVAMLLG
..| |.. . ||..|..|  |  
QHCWQHDPKKRPHFSQIVKRLSQ
Kinase IRAK-0_ar-2.AA Pkinase_Tyr 514-526 46 1.229388 2.78 Pfam 258-270 (270) Show / Hide 
Range on Protein: 514-526
Range on HMM: 258-270/270
Sequence Identity: 46% (6 aa)

EARPTMSDVVAML
| |||.|... .|
EDRPTFSEIHEQL