IRAK-14_b-2

Species: S.moellendorffii
Alias: IRAK-14_b-2
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-14

Sequence

Name Sequence Type Origin Length Description Download
IRAK-14_b-2.AA Protein None 862 None Fasta, JSON
IRAK-14_b-2.NA RNA None 2589 None Fasta, JSON
IRAK-14_b-2.kin_dom Protein Kinase Domain None 201 None Fasta, JSON

Protein domain

Protein domains of IRAK-14_b-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IRAK-14_b-2.AA IRAK 519-715 39 2.5e-68 233.32 In-house 1-218 (317) Show / Hide
Range on Protein: 519-715
Range on HMM: 1-218/317
Sequence Identity: 39% (86 aa)

FDETLLLGVGGFGKVYRGELFDGTK--VAVK----RGNPRSEQGLTEFQT---EIEMLSKLRHLHLVSLIGYCEEHCEMILVYECMANGTLRAHLYGSDL
|.. ...| |||| ||||. ...|   .|||      ..  ..   .||.   |.. ....|| ..|.| ||| |  .  |||. |.||.|.. | . | 
FHKDNRIGEGGFGCVYRGQ-WKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDG

--PP--LSWKQRLEICIGAARGLHYLHTGAEQGTIIHRDVKTTNILLDENFVAKVSDFGLSKTG---PSLDRTHV----STAVKGSFGYLDPEYFR--RQ
  ||  ||| ||..||.|.|.|...||.      |||.|.|. |||||..|..| .||||   |   ... .. .       |.|.  |. ||. |    
QCPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQG

QLTEKSDVYSFGVVLFEVL
||| |.||||||.|| |||
QLTKKTDVYSFGIVLLEVL

Kinase IRAK-14_b-2.AA TKL 525-790 22 4.2e-58 199.33 In-house 1-364 (364) Show / Hide
Range on Protein: 525-790
Range on HMM: 1-364/364
Sequence Identity: 22% (83 aa)

LGVGGFGKVYRGELFD---------GTKVAVKRGNPRSEQGLTE---------------------------FQTEIEMLSKLRHLHLVSLIGYCEEH-C-
.| ||||.||.|..           |. ||||. . ....  |.                           .  || |.|.||| ..|...||| .  | 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-----------EMILVYECMANGTLRAHLYGSDLPPLSWKQRLEICIGAARGLHYLHT-----GAEQGT--IIHRDVKTTNILLDENFV-----------
           .. .|.| . .|.|. .|         | ||. .....|||..|||.     .    .  ||||| |. |||.|||.            
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCT---KPPIIHRDLKSKNILVDENWTNVSNYMYNPNA

---AKVSDFGLSK-TGPSLDRTHVSTA----------------VKGSFGYLDPEYFRRQ----------------QLTEKSDVYSFGVVLFEVLCARPAI
   .|..|||||.   .| . .. .|.                . |..... || .| |                . .||.||||||.||.|.|. ..  
DWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPY

NPALPREQV------NIAEWAMQYQRMGALEQIVDA--NLKGQCSQESLQKFGETAEKCLAEQGIDRPAMGDVLWNL
    .....       ..... . ..   .  |       . ..    .. . . ...| ..   .|| . ..|  |
YDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHK-M-CPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL

Kinase IRAK-14_b-2.AA TKL-Unique 524-715 32 4e-49 169.52 In-house 4-222 (290) Show / Hide
Range on Protein: 524-715
Range on HMM: 4-222/290
Sequence Identity: 32% (73 aa)

LLGVGGFGKVYRGELFDGTKVAVKRGNPRSEQGLT---EFQTEIEMLSKLR-HLHLVSLIGYCE----EHCEMILVYECMANGTLRAHLYG--------S
..| ||.|.||.|. . |..||.|. .| ... ..   ||  |.  ..||. |  .| ..|||        .|..| |..  |.|. .|          .
KIGEGGYGQVYKGK-WRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNN

DLPPLSWKQRLEICIGAARGLHYLHTGAEQGTIIHRDVKTTNILLDEN-----FVAKVSDFGLSKTGPSLDRTHVS-------TAVKGSFGYLDPEYFRR
.  .|...||. . | .|.|..|||.  ....||||| |..|.|.|.|     . .|..||||||.  . ... ..       . ..||| .. || .|.
NNCKLNMQQRVKMAIDIAQGMYYLHH--CEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRM

--QQLTEKSDVYSFGVVLFEVL
   | .|||||||||.|| | .
NFCQYSEKSDVYSFGIVLWEIA

Kinase IRAK-14_b-2.AA Pkinase_Tyr 519-715 30 3.8e-40 136.61 Pfam 1-208 (270) Show / Hide
Range on Protein: 519-715
Range on HMM: 1-208/270
Sequence Identity: 30% (64 aa)

FDETLLLGVGGFGKVYRGELF-----DGTKVAVKRGNPRSEQG---LTEFQTEIEMLSKL-RHLHLVSLIGYCE-EHCE--MILVYECMANGTLRAHLYG
      || | ||.||.|...     ....||||  .. . .    . .|  |......| .| ..|.|.| |  .     ...| | |..| |. .|  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

S--DLPPLSWKQRLEICIGAARGLHYLHTGAEQGTIIHRDVKTTNILLDENFVAKVSDFGLSKTGPSLDRT-HVSTAVKGSFGYLDPEYFRRQQLTEKSD
   | .||. |. |..|.  |.|. ||.       .||||. . |.|..||.|.|..||||...  . |   ....  |     . || ..    |.|||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKN----CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSD

VYSFGVVLFEVL
|.||||...|..
VWSFGVLMWEIF

Kinase IRAK-14_b-2.AA Dicty4 519-715 33 5.9e-40 131.05 In-house 1-211 (277) Show / Hide
Range on Protein: 519-715
Range on HMM: 1-211/277
Sequence Identity: 33% (72 aa)

FDETLLLGVGGFGKVYRGELFDGTKVAVKRG---NPR-SEQGLTEFQTEIEMLSKLRHLHLVSLIGYCE----EHCEMILVYECMANGTLRAHLYGS---
 . . ..| |.||.||.|    |..||||     |   .|  |.||  |.. ..|.|| ... . |.|     .  .|  | | |  |.| . |  .   
INIEQRIGKGSFGEVYKGT-WRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNL-YSLLHDKPS

---DLPPLSWKQRLE---ICIGAARGLHYLHTGAEQGT--IIHRDVKTTNILLDENFVAKVSDFGLSK-TGPSLDRTHVSTAVKGSFGYLDPEYFRRQQL
   .  .|.|  ..    ... ||||. .||.     .  ||||| |. |.| |.|...||.|||||.   .  | .   ....|. ..  ||  . |  
EQQQSIKLDWPLIKRAMRMAFDAARGMNWLHC----CNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPY

TEKSDVYSFGVVLFEVL
.||.|||||| ||.| |
NEKADVYSFGIVLWEIL

Kinase IRAK-14_b-2.AA TK 519-715 16 1.2e-38 126.71 In-house 1-388 (486) Show / Hide
Range on Protein: 519-715
Range on HMM: 1-388/486
Sequence Identity: 16% (66 aa)

FDETLLLGVGGFG---KVYRGELFDG--------------------------TKVAVKRGNPRSEQGLTEFQT-----------------EIEMLS--KL
      || | ||   .||.||....                          |.||||   . ...  .||.                  |..|..  ..
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHLHLVSLIGYCEEHCE------------MILVYECMANGT----LRAHLYGSDLP--------------------------------------------
.| ..|.|.|.| .. .            ...| |.|..|     || .|  .. .                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------------------------------PLSWKQRLEICIGAARGLHYLHTGAEQG-----TIIHRDVKTTNILLDENFV-----------AKVSDFG
                              .|. .|.| .|  .|.|. |||   ...      ..|||. . |.|..|| |           .|..|||
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLH---SKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFG

LSKTG-----PSLDRTHVSTAVKGSFG---------------------------YLDPEYFRRQQ---------LTEKSDVYSFGVVLFEVL
||..|       ... .  .....  .                           .. || .. ..          |.||||.||||...|..
LSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIF

Kinase IRAK-14_b-2.AA MLK 519-715 27 2.4e-37 127.13 In-house 1-230 (291) Show / Hide
Range on Protein: 519-715
Range on HMM: 1-230/291
Sequence Identity: 27% (66 aa)

FDETLLLGVGGFGKVYRGELFDGTK-----VAVKR--GNPRSEQGLTE-----FQTEIEMLSKLRHLH----LVSLIGYCEEH-CEMILVYECMANGTLR
...   .|.|.||||..|. . ..      |||||   ... . . |.     |..|.. |..|.|.      . . | | .. |.  .| | ...| | 
IQFHEWIGSGSFGKVWKGR-WRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLY

AHLYG-SDLPP-----------LSWKQRLEICIGAARGLHYLHTGAEQGTIIHRDVKTTNILLDE------NFVAKVSDFGLSKTGPSLDRTHVS--TAV
  |.| .. .             .  . . ..   |||.||||  | . .||||| |  |||.||      . ..|..|||.|.   .. ... .  .  
NVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPK-PIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSR---DWHQMC-TNMMSN

KGSFGYLDPEYF---RRQQLTEKSDVYSFGVVLFEVL
.|.. .  || .   | .. .||.||.|.|||| |.|
AGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEML

Kinase IRAK-14_b-2.AA Pkinase 519-719 29 6.1e-37 131.71 Pfam 1-210 (293) Show / Hide
Range on Protein: 519-719
Range on HMM: 1-210/293
Sequence Identity: 29% (65 aa)

FDETLLLGVGGFGKVYRGELFDGTK-VAVKRGNPRSEQGLTEFQT-----EIEMLSKLRHLHLVSLIGYCEEHCEMILVYECMANG----TLRAHLYGSD
.     .| |.||.||..   .  | ||||. . | ..   . ||     ||... .|.| . | |....|.. .. .| |.. .|     | ... ...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

LPPL--SWKQRLEICIGAARGLHYLHTGAEQGTIIHRDVKTTNILLDENFVA----KVSDFGLSKTGPSLDRTHVSTAVKGSFGYLDPEYFR-RQQLTEK
  ..  |...   ..   .||| |.|       |||||.|  |||.|.| .     |..||||.|    . . .  | . |. .|. ||  | .|  . |
HGCFYFSEWECKFYMYQILRGLEYCHS-M---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

SDVYSFGVVLFEVLCARP
.|..|.|..|.|.|| ||
VDMWSCGCILYEMLCGRP

Kinase IRAK-14_b-2.AA LRRK 519-715 24 6.7e-35 120.89 In-house 1-276 (351) Show / Hide
Range on Protein: 519-715
Range on HMM: 1-276/351
Sequence Identity: 24% (70 aa)

FDETLLLGVGGFG-KVYRGELFD---------------------------GTKVAVKRGNPR---------SEQG-------------------------
. .  ..|.|||| .|||... .                           ...||.|  |           .  .                         
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

LTEFQTEIEMLSKLRHLHLVSLIGYCEEHCEMILVYECMANGTLRAHLY---GSDL----PPLSWKQRLEICIGAARGLHYLHTGAEQGT--IIHRDVKT
. ||. |. ..|.|.| ..|||.|.| ... |..  | . .|.|  .|     . .    . .||  .|.| .  |.|. |||      .  ||||| |.
FREFRHEVWIMSHLNHPNIVSLKGFCIHPLCMVM--EYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLH----SHNPPIIHRDLKS

TNILL---D---------ENFVAKVSDFGLSKTGPSLDRTHVSTAVKGSFGYLDPEYFR---RQQLTEKSDVYSFGVVLFEVL
 ||||   .         .. .||..|||.|    . ... |   . | .|.. ||  |   . . |||.|.||||..|.| |
PNILLWSSPQNHSPNYPNAHVCAKIADFGISRMF-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELL

Kinase IRAK-14_b-2.AA TyrKc 519-790 25 8.1e-35 122.91 SMART 1-280 (280) Show / Hide
Range on Protein: 519-790
Range on HMM: 1-280/280
Sequence Identity: 25% (75 aa)

FDETLLLGVGGFGKVYRGELFDGTKVAVKRGNPRSEQGLTEFQTEIEMLSKL--RHLHLVSLIGYCEEH-------CEMILVYECMANGTLRAHLYGSDL
      || | ||.||.|..   ..||||  .. .   . .|  |.....||  .| ..| |.|.| ..         . .| | |..| |. .|  .  
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

PPLSWKQRLEICIGAARGLHYLHTGAEQGTIIHRDVKTTNILLDENFVAKVSDFGLSKTGPSL-------DRTHVST--AVK--GSFGYLDPEYFRRQQL
  |..|. |..|. .|.|  |||       .||||  . |.|..||...|.||||||. . .        |  ....    |       . || ..    
K-LCMKDLLSFCWQIACGMEYLHSK----NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

TEKSDVYSFGVVLFEV--LCARPAINPAL-PREQVNIAEWAMQYQRMGALEQ---IVDANLKGQCSQESLQKFGETAEKCLAEQGIDRPAMGDVLWNL
|.||||.||||...|.  ... |  .... . .   . |. .|  ||   .    .         . .  ..  .  ..| .|.  ||| . ..   .
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS--------FVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF

Kinase IRAK-14_b-2.AA DRK 526-715 34 2.1e-34 113.97 In-house 8-196 (258) Show / Hide
Range on Protein: 526-715
Range on HMM: 8-196/258
Sequence Identity: 34% (68 aa)

GVGGFGKVYRGELFDGTKVAVKRGNPRSEQ---GLTEFQTEIEMLSKLRHLHLVSLIGYCEEHCEMILVYECMANGTLRAHLYGSDLPPLSWKQRLEICI
| |..| |.||    ||.||||.     .     | ||. ||.....|||   .  .| | .  .   . | |  | |   |    .  ..|  .. . .
GRGNYGEVFRGT-WRGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESI-EMDWPLMKQMMF

GAARGLHYLHTGAEQGTIIHRDVKTTNILLDENFVAKVSDFGLSKT--GPSLDRTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVVLFEVL
 .|.|. |||       ||||| |. | | ||..  ||.||||| |     ....   |.. |  .   ||  | |  ||| |||||..|| |..
DCAKGMIYLH--CCNPIIIHRDLKSHNLLVDEHWQVKVADFGLS-TRFKKHKQHKFAMTMC-GTPCWTAPEVLRNQRYTEKADVYSFAIVLWECV

Kinase IRAK-14_b-2.AA RIPK 525-715 31 9.9e-34 112.31 In-house 1-222 (290) Show / Hide
Range on Protein: 525-715
Range on HMM: 1-222/290
Sequence Identity: 31% (71 aa)

LGVGGFGKVYRGELFD-GTKVAVKR--GNPRS----EQGLTEFQTEIEMLSKLRHLHLVSLIGYCEEH-----CE-MILVYECMANGTLRAHLYGSDL--
.| ||||.|..    . |. ||.|   . ..     .|  ..   | ... |||. | |.. | |..      |. . .| | |.|| | .|.  .    
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSL-WHFLHTKWPY

--PPLSWKQRLEICIGAARGLHYLHTGAEQG-TIIHRDVKTTNILLDENFVAKVSDFGLSK-TGPS---LDRT-----HVSTAVK--GSFGYLDPEYFR-
  .|. |. |  .    ..| .|||    ..  ||||| |. |||.| || .|..||||..  . |    ||        ..  .  |   |..|| || 
QHHPDPWPLRCRMIHEISCGMCYLH---SMNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRT

--RQQ---LTEKSDVYSFGVVLFEVL
  .      |.|.|||||..|..|||
DNKKPIKVVTPKYDVYSFAIVMWEVL

Kinase IRAK-14_b-2.AA TK-Unique 519-716 24 2.6e-30 101.76 In-house 1-234 (294) Show / Hide
Range on Protein: 519-716
Range on HMM: 1-234/294
Sequence Identity: 24% (58 aa)

FDETLLLGVGGFGKVYRGELFDGT-------KVAVKRGN-PRSEQGLTEFQTEIEMLSKLR-HLHLVSLIGYCEEHC-EMILVYECMANGTLRAHLYGSD
.    ..| | || |.|||.. ..       .||||  . . ...   .|  ||.|...|  | ..|...|.| .    . ...| ...|.|. .|  . 
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

LP------------------------PLSWKQRLEICIGAARGLHYLHTGAEQGTIIHRDVKTTNILLDENFVAKVSDFGLSK---TGPSLDRTHVSTA-
 .                        |.| |. . .... |.|. ||.   ..  |.|||. . |.|| |..|.|..|||...   |    .. ....  
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKK--IVHRDLCARNVLLTEDKVCKICDFGMARDVYT----NGVYSMMCS

-VKGSFGYLDPEYFR--RQQL-TEKSDVYSFGVVLFEVLC
  . .  .. ||...  ...  |.||||.||||...|...
QGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFT

Kinase IRAK-14_b-2.AA S_TKc 519-793 22 4.5e-26 93.85 SMART 1-231 (231) Show / Hide
Range on Protein: 519-793
Range on HMM: 1-231/231
Sequence Identity: 22% (65 aa)

FDETLLLGVGGFGKVYRGELFD-GTKVAVKRGNPRSEQGLTEFQTEIEMLSKLRHLHLVSLIGYCEEHCEMILVYECMAN--GTLRAHLYGSDLPP----
..   ..| |.|||||..   . | .||.|. .         .. ||..|.| .| ..| |......  .. .| |.. .  |.|. ..     ..    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LSWKQRLEICIGAARGLHYLHTGAEQGTIIHRDVKTTNILLDENFVAKVSDFGLSKTGPSLDRTHVSTAVKGSFGYLDPEYFRRQQLTE-KSDVYSFGVV
..  .   ..   ...| |.|   ..  |||||.|  ||||||  . |..||||..           | . |.  |. || .   . .  |.|..|.|..
FPE-HARFYMYQICCALEYCH---SH-GIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI

LFEVLCARPAINPALPREQVNIAEWAMQYQRMGALEQIVDANLKGQCSQESLQKFGETAEKCLAEQGIDRPAMGDVLW------NLEYA
|.| || .|              . .| ....|                 | .      .|||     .||   ..|       . .. 
LYEMLCGYPPFP-----------QMQMMFKKIG-----------------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF