Gene IRAK-Un_ax (S.moellendorffii)
IRAK-Un_ax
Species: S.moellendorffii
Alias: IRAK-Un_ax
External Links:
Annotation:
Sequence
Name | Sequence Type | Origin | Length | Description | Download |
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IRAK-Un_ax.AA | Protein | None | 288 | None | Fasta, JSON |
IRAK-Un_ax.NA | RNA | None | 867 | None | Fasta, JSON |
IRAK-Un_ax.kin_dom | Protein Kinase Domain | None | 195 | None | Fasta, JSON |
Protein domains of IRAK-Un_ax.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | IRAK-Un_ax.AA | TKL | 1-270 | 19 | 2.2e-54 | 186.97 | In-house | 2-364 (364) | Show / Hide |
Range on Protein: 1-270 Range on HMM: 2-364/364 Sequence Identity: 19% (76 aa) GRGGFASVYKGVIDN----------HFVAVKYLTS-------------------------SDLSDKARRDFENEVSTICLLQHKNVVKLFGFCSEKEH-- |.|||. ||||. . |||| . | .. . ..| .|.|. . |.| |.|.. |.| . .. GSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGC -----------KLIVCEFIENGNLSEALFSSPDKGLELNWTARYNICVGVAQGLAYLHGET---SQAT--IVHRDIKALNILLASNLE------------ || |....|.| . | | | ... ..|.|..||| .. .. . |.|||.| |||. .|.. VCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCT-KPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD --AKISDFGLARLIQEDRSYISTR------------------AAGTVGYLALEYAL----------------SGQFTEKADVYSFGILVLEILSGRISMD .||.||||.| .... . | || ...| | .....||.|||||||. |||.... WCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR--- FTLSDGDSFLLERVTWNVFQSGHLLEMIDK-------RLDVDDERD----------------IHEMERVFLVALHCTHASGSRRPSMFRVVGML ... . .|| ...|. . . .... . .| .. . |||. ... | -----------------PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL |
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Kinase | IRAK-Un_ax.AA | TKL-Unique | 1-196 | 30 | 5.6e-42 | 145.79 | In-house | 6-226 (290) | Show / Hide |
Range on Protein: 1-196 Range on HMM: 6-226/290 Sequence Identity: 30% (69 aa) GRGGFASVYKGVIDNHFVAVKYLT-SSDLSDKARRDFENEVSTICLLQ-HKNVVKLFGFCS----EKEHKLIVCEFIENGNLSEALF------SSPDKGL |.||...||||. ||.| . .|.| . ...|||||... |. |.|.|...|.| . ||.|... |.| . | . . GEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNC ELNWTARYNICVGVAQGLAYLHGETSQATIVHRDIKALNILLASN-----LEAKISDFGLARLIQEDRSYISTRA--------AGTVGYLALEYALSG-- .||. |... .|||. ||| .....| |||.| .|.|. .| . .||.||||... . .... |. ..| | |.. KLNMQQRVKMAIDIAQGMYYLH--HCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEV-LRMNF -QFTEKADVYSFGILVLEILSGRI |..||.||||||| . ||... | CQYSEKSDVYSFGIVLWEIATRKI |
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Kinase | IRAK-Un_ax.AA | IRAK | 1-195 | 34 | 2e-41 | 143.91 | In-house | 8-221 (317) | Show / Hide |
Range on Protein: 1-195 Range on HMM: 8-221/317 Sequence Identity: 34% (74 aa) GRGGFASVYKGVIDNHF--VAVKYLTSSDLS--DKARRDFEN---EVSTICLLQHKNVVKLFGFCSEKEHKLIVCEFIENGNLSEALFSSPDKGLE--LN | |||. ||.|...| .||| | . . .. .. | |. . |...|.|.| | |.|.| . | ... || | | . | GEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQCPPKPLS WTARYNICVGVAQGLAYLHGETSQATIVHRDIKALNILLASNLEAKISDFGLARL-----IQEDRSY---ISTRAAGTVGYLALEYAL--SGQFTEKADV | | || | | |. .|| . | |.||| |||| ....||.||||.| |. .| . . || |.. |. .|| | | || WHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQLTKKTDV YSFGILVLEILSGR ||||| .||.|.|. YSFGIVLLEVLTGC |
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Kinase | IRAK-Un_ax.AA | TK | 1-193 | 18 | 4.8e-40 | 131.41 | In-house | 8-389 (486) | Show / Hide |
Range on Protein: 1-193 Range on HMM: 8-389/486 Sequence Identity: 18% (72 aa) GRGGFA---SVYKGVIDNH---------------------------FVAVKYLTS-SDLSDKARRD--------------FENEVSTIC--LLQHKNVVK |.| | |||| .. |||| |.. .. |.....| . .| . | |..|.|.|. GEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVR LFGFCSEK------------EHKLIVCEFIENGN----LSEALFSSPDKGLE------------------------------------------------ |.| |... |. .|| |. ..|. | . | ....|. . LYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKD ------------------------LNWTARYNICVGVAQGLAYLHGETSQAT---IVHRDIKALNILLASNLE-----------AKISDFG--------L |. . .|. .|.|..||| . .||||. | |.|...|. .||.||| | HPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVL ARLIQEDRSYISTRAAGTVG-------------------------YLALEYALSGQ---------FTEKADVYSFGILVLEILS || |..| | ... || . ..| | .... ||.| ||.|||.|. ||.. ARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFT |
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Kinase | IRAK-Un_ax.AA | Dicty4 | 1-192 | 31 | 2e-38 | 125.86 | In-house | 8-211 (277) | Show / Hide |
Range on Protein: 1-192 Range on HMM: 8-211/277 Sequence Identity: 31% (64 aa) GRGGFASVYKGVIDNHFVAVKYL--TSSDLSDKARRDFENEVSTICLLQHKNVVKLFGFCS----EKEHKLIVCEFIENGNLSEALFS---SPDKGLELN |.|.|..|||| |||| | . ... . .| .||. | ..| |.... | | ... .|| |. ||| . | . . .| GKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLD WTARYN---ICVGVAQGLAYLHGETSQATIVHRDIKALNILLASNLEAKISDFGLARLIQEDRSYIS--TRAAGTVGYLALEYALSGQFTEKADVYSFGI |. . .. .|.|...||. . |.|||.|. |.| |. .|..||||....... . . |.||... | | . ..|||||||||| WPLIKRAMRMAFDAARGMNWLHC--CNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADVYSFGI LVLEIL . ||| VLWEIL |
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Kinase | IRAK-Un_ax.AA | Pkinase_Tyr | 1-193 | 32 | 1.4e-37 | 127.88 | Pfam | 8-209 (270) | Show / Hide |
Range on Protein: 1-193 Range on HMM: 8-209/270 Sequence Identity: 32% (67 aa) GRGGFASVYKGVID------NHFVAVKYLTSSDLSDKA--RRDFENEVSTICLL-QHKNVVKLFGFCS-EKEH--KLIVCEFIENGNLSEALFSS--PDK |.| | .||||. . . |||| | . .... |.|| .|... . | .|.|.|.| | |. ..|. .|| |. ..|.| . | . ... GEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQ GLELNWTARYNICVGVAQGLAYLHGETSQATIVHRDIKALNILLASNLEAKISDFGLARLI-QEDRS-YISTRAAGTVGYLALEYALSGQFTEKADVYSF | . . ..|. .|.|..||. ..|||. | |.|...|. .||.||||||.| .| . .. . . .|.| | ||.| ||.|| PLTMKD--LLQMCWQIAKGMEYLESKN----CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF GILVLEILS |.| ||.. GVLMWEIFT |
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Kinase | IRAK-Un_ax.AA | MLK | 1-196 | 27 | 1.4e-35 | 120.96 | In-house | 8-234 (291) | Show / Hide |
Range on Protein: 1-196 Range on HMM: 8-234/291 Sequence Identity: 27% (63 aa) GRGGFASVYKGVIDNHF-----VAVKYLTSSDLSDKAR-----RDFENEVSTICLLQHKN----VVKLFGFCSEKEH-KLIVCEFIENGNLSEALFSSPD | |.| .|.||. | |||| ... ||.. .||| |. |.|.| .... | |.. .. .|| |..|.| |.. | . .. GSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARS KGL----------ELNWTARYNICVGVAQGLAYLHGETSQATIVHRDIKALNILLAS------NLEAKISDFGLARLIQEDRSYISTRAAGTVGYLALEY |. |... .|.|..||| . . .|.|||.| |||.. .. .||.|||..| ... . .|||. . | | KWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMA-PKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYAWMAPEV ---ALSGQFTEKADVYSFGILVLEILSGRI . .....||.||.|.|.. |.|.... IQQFRCEKYSEKCDVWSWGVVLWEMLTREV |
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Kinase | IRAK-Un_ax.AA | Dicty4-Unclassified | 1-194 | 33 | 1.9e-35 | 118.82 | In-house | 8-204 (263) | Show / Hide |
Range on Protein: 1-194 Range on HMM: 8-204/263 Sequence Identity: 33% (69 aa) GRGGFASVYKGVIDNHFVAVKYLTSSDLSDKAR----RDFENEVSTICLLQHKNVVKLFGFC----SEKEHKLIVCEFIENGNLSEALF---SSPDKGLE |.| |. |.||. |||| . . ..|.| || || ..|| | ||. | | | | || ||. ||| | | .. . GKGHFSKVHKGNWKGKDVAVKKFNEN--KFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQPIK LNWTARYNICVGVAQGLAYLHGETSQATIVHRDIKALNILLASNLEAKISDFGLARLIQEDRSYISTRAAGTVGYLALEYALSGQFTEKADVYSFGILVL |. | . .|||...|| ..|||||. |||. . .|| |||..| | | . | |||. . | .. |.||||.... LDDTLIIKYAFDIAQGMQHLH----TRNFIHRDIKSSNILMDKHFNIKIADFGISRVI--DFNFNMTTIAGTPKWESPECLMHESYNQKSDVYSYAMMLY EILSG | . | ELATG |
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Kinase | IRAK-Un_ax.AA | LRRK | 1-196 | 24 | 4.1e-34 | 118.07 | In-house | 8-281 (351) | Show / Hide |
Range on Protein: 1-196 Range on HMM: 8-281/351 Sequence Identity: 24% (70 aa) GRGGFA-SVYKGVIDN----------------------------HFVAVKYLTS----SDLSD-----------------------------KARRDFEN |||||. .||.. . ||.| .. .| | .| | | . GRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTID-NDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRAFREFRH EVSTICLLQHKNVVKLFGFCSEKEHKLIVCEFIENGNLSEALFSSPDKGL-----ELNWTARYNICVGVAQGLAYLHGETSQAT--IVHRDIKALNILL- ||. .. |.| |.|.|.||| .. .| |.. .|.|.. |... |. ...|. .. | . .| |..||| .. |.||| | |||| EVWIMSHLNHPNIVSLKGFCI--HPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHS----HNPPIIHRDLKSPNILLW AS-----------NLEAKISDFGLARLIQEDRSYISTRAAGTVGYLALEYALSG---QFTEKADVYSFGILVLEILSGR-I | . |||.|||. |. | ... . . |. |..| | . ..|||.|.||||.. |.|... . SSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHH |
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Kinase | IRAK-Un_ax.AA | Pkinase | 1-195 | 27 | 9.4e-34 | 120.43 | Pfam | 8-209 (293) | Show / Hide |
Range on Protein: 1-195 Range on HMM: 8-209/293 Sequence Identity: 27% (57 aa) GRGGFASVYKGV--IDNHFVAVKYLTSSDLSDKARRDFEN--EVSTICLLQHKNVVKLFGFCSEKEHKLIVCEFIENG----NLSEALFSSPDKGLEL-- |.|.|..|||.. ... |||| . .. ... .. . |.. |.|.|.|.|.... .| | .| |. |.| |.. . ... . GSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--WRHGCFYF NWTARYNICVGVAQGLAYLHGETSQATIVHRDIKALNILLASNLEA----KISDFGLARLIQEDRSYISTRAAGTVGYLALEYAL-SGQFTEKADVYSFG . ... ...||.|.| . |.|||.| |||. .| . ||.|||||..... .. | .|| .|.| | . . . |.|..|.| SEWECKFYMYQILRGLEYCHSM----GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCG ILVLEILSGR ... | |.|| CILYEMLCGR |
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Kinase | IRAK-Un_ax.AA | STE | 1-195 | 19 | 4e-32 | 110.76 | In-house | 8-265 (359) | Show / Hide |
Range on Protein: 1-195 Range on HMM: 8-265/359 Sequence Identity: 19% (52 aa) GRGGFASVYKGVID-----------------NHFVAVKYLTSSDLS---------------DKARRDFENEVSTICLLQ--HKNVVKLFGFCSEK----- |.|.| .|||.. . ..|.| . .. . .. . ....|... .. |.|.|| .| . . GKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHK --EHKLIVCEFIENGNLSEALFS--SPDKGLE----------LNWTARYNICVGVAQG-LAYLHGETSQATIVHRDIKALNILLASNLEAKISDFGLARL .. |. |....| |.. . . .. |.| .. |. ||. . .| |.||| |.|||||. |||| .|..|||.. NDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAY--ICRQILKGLLYYLHSHH----IIHRDIKPANILL-----VKLCDFGVCGQ IQE---------------DRSYISTRAAGTVGYLALEYALS------GQFTEKADVYSFGILVLEILSGR ... ... .. .|| . | | . .. ..|.|..|.|....| . |. LTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK |
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Kinase | IRAK-Un_ax.AA | LISK | 1-151 | 29 | 1.6e-31 | 99.54 | In-house | 3-159 (296) | Show / Hide |
Range on Protein: 1-151 Range on HMM: 3-159/296 Sequence Identity: 29% (47 aa) GRGGFASVYKGVID--NHFVAVKYLTS----SDLSDKARRDFENEVSTICLLQHKNVVKLFGFCSE-KEHKLIVCEFIENGNLSEALFSSPDKGLELNWT |.|.|..|||| . .|.| ... ... . ... .. || .. .|.|.|.|. .| | . . . || |.|. |.| . |.... . | |. GKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPE-YQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPWP ARYNICVGVAQGLAYLHGETSQATIVHRDIKALNILLASN----LEAKISDFGLARLIQEDR | .| ...|.|..||| |.||| |. |.|. | ..|. |||.||...... QRVKIALDIACGMSYLH----SMNIIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCEN |
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Kinase | IRAK-Un_ax.AA | TyrKc | 1-270 | 25 | 1.3e-29 | 105.61 | SMART | 8-280 (280) | Show / Hide |
Range on Protein: 1-270 Range on HMM: 8-280/280 Sequence Identity: 25% (76 aa) GRGGFASVYKGVIDNHFVAVKYLTSSDLSDKARRDFENEVSTICLL--QHKNVVKLFGFCSEK-------EHKLIVCEFIENGNLSEALFSSPDKGLELN |.| | ||||. . |||| | .. |.|| .| . | | .|.|.|.|.| |... | .|| |. ..|.| . | .. .| |. GEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK---LC WTARYNICVGVAQGLAYLHGETSQATIVHRDIKALNILLASNLEAKISDFGLARLIQED-------RSYI-----STRAAGTVGYLALEYALSGQFTEKA . ..|. .|.| .||| ..|||. | |.|...|. .|||||||.| | .| | .... . .|.| | ||.| MKDLLSFCWQIACGMEYLHSK----NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKS DVYSFGILVLEILSGRISMDFTL---SDGDSFLLERVTWNVFQSGHLLEMIDKRLDVDDERDIHEM------ERVFLVALHCTHASGSRRPSMFRVVGML ||.|||.. ||.. . . .. . . ..|. .. . . .| . .. . . | |. . ||.. .. . DVWSFGVCMWEIFT-YGQQPYPGMIQQ----MMSNQEVIEYVKQGYRMPQPPNDY---------PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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Kinase | IRAK-Un_ax.AA | S_TKc | 1-247 | 23 | 1.2e-22 | 82.43 | SMART | 8-231 (231) | Show / Hide |
Range on Protein: 1-247 Range on HMM: 8-231/231 Sequence Identity: 23% (62 aa) GRGGFASVYKGVIDN--HFVAVKYLTSSDLSDKARRDFENEVSTICLLQHKNVVKLFGFCSEKEHKLIVCEFIEN--GNLSEALFSSPDKG----LELNW |.|.|..|||.. . . ||.| . .....|.. .|.|.|||.... . .| .| |.... |.| . . . . .| . . GKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-H TARYNICVGVAQGLAYLHGETSQATIVHRDIKALNILLASNLEAKISDFGLARLIQEDRSYISTRAAGTVGYLALEYALSGQFTE-KADVYSFGILVLEI ...| . ....|.|.| |. |.|||.| |||| . . ||.||||||.. | || |.| | ... |.|..|.|... | ARFY--MYQICCALEYCH---SH-GIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM LSGRISMDFTLSDGDSFLLERVTWNVFQSGHLLEMIDKRLDVD-----DERDIHEME-----RVFL |.|. . . ..... | ....|.| |..| .. ..| .. LCGYPPFP-----QMQMMFKKIG-----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | IRAK-Un_ax.AA | LISK | 176-191 | 56 | 5.1e-05 | 12.03 | In-house | 217-232 (296) | Show / Hide |
Range on Protein: 176-191 Range on HMM: 217-232/296 Sequence Identity: 56% (9 aa) TEKADVYSFGILVLEI .|..||.||||...|| DESCDVFSFGIVLCEI |
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Kinase | IRAK-Un_ax.AA | TK | 242-270 | 17 | 0.036999 | 2.17 | In-house | 447-486 (486) | Show / Hide |
Range on Protein: 242-270 Range on HMM: 447-486/486 Sequence Identity: 17% (7 aa) M-----------ERVFLVALHCTHASGSRRPSMFRVVGML | | .... . | |. ..||.. .. .| MRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL |