IRAK-Un_ax

Species: S.moellendorffii
Alias: IRAK-Un_ax
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
IRAK-Un_ax.AA Protein None 288 None Fasta, JSON
IRAK-Un_ax.NA RNA None 867 None Fasta, JSON
IRAK-Un_ax.kin_dom Protein Kinase Domain None 195 None Fasta, JSON

Protein domain

Protein domains of IRAK-Un_ax.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IRAK-Un_ax.AA TKL 1-270 19 2.2e-54 186.97 In-house 2-364 (364) Show / Hide
Range on Protein: 1-270
Range on HMM: 2-364/364
Sequence Identity: 19% (76 aa)

GRGGFASVYKGVIDN----------HFVAVKYLTS-------------------------SDLSDKARRDFENEVSTICLLQHKNVVKLFGFCSEKEH--
|.|||. ||||.  .            |||| . |                         .. . ..|  .|.|.  .  |.| |.|.. |.| . ..  
GSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGC

-----------KLIVCEFIENGNLSEALFSSPDKGLELNWTARYNICVGVAQGLAYLHGET---SQAT--IVHRDIKALNILLASNLE------------
             || |....|.| . |           |  | ... ..|.|..||| ..   .. .  |.|||.|  |||. .|..            
VCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCT-KPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD

--AKISDFGLARLIQEDRSYISTR------------------AAGTVGYLALEYAL----------------SGQFTEKADVYSFGILVLEILSGRISMD
  .||.||||.| .... .   |                     || ...| |                   .....||.|||||||.  |||....   
WCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR---

FTLSDGDSFLLERVTWNVFQSGHLLEMIDK-------RLDVDDERD----------------IHEMERVFLVALHCTHASGSRRPSMFRVVGML
                 ...  .  .||          ...|. .                  . ....   . .| ..  . |||. ...  |
-----------------PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL

Kinase IRAK-Un_ax.AA TKL-Unique 1-196 30 5.6e-42 145.79 In-house 6-226 (290) Show / Hide
Range on Protein: 1-196
Range on HMM: 6-226/290
Sequence Identity: 30% (69 aa)

GRGGFASVYKGVIDNHFVAVKYLT-SSDLSDKARRDFENEVSTICLLQ-HKNVVKLFGFCS----EKEHKLIVCEFIENGNLSEALF------SSPDKGL
|.||...||||.     ||.| .   .|.| . ...|||||...  |. |.|.|...|.|        .  ||.|... |.| . |           . .
GEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNC

ELNWTARYNICVGVAQGLAYLHGETSQATIVHRDIKALNILLASN-----LEAKISDFGLARLIQEDRSYISTRA--------AGTVGYLALEYALSG--
.||.  |...   .|||. |||  .....| |||.| .|.|. .|     . .||.||||...   .   ....          |.  ..| |  |..  
KLNMQQRVKMAIDIAQGMYYLH--HCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEV-LRMNF

-QFTEKADVYSFGILVLEILSGRI
 |..||.||||||| . ||... |
CQYSEKSDVYSFGIVLWEIATRKI

Kinase IRAK-Un_ax.AA IRAK 1-195 34 2e-41 143.91 In-house 8-221 (317) Show / Hide
Range on Protein: 1-195
Range on HMM: 8-221/317
Sequence Identity: 34% (74 aa)

GRGGFASVYKGVIDNHF--VAVKYLTSSDLS--DKARRDFEN---EVSTICLLQHKNVVKLFGFCSEKEHKLIVCEFIENGNLSEALFSSPDKGLE--LN
| |||. ||.|...|    .||| | .   .  .. .. |     |. . |...|.|.| | |.|.| .    | ... || |   |      .    | 
GEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQCPPKPLS

WTARYNICVGVAQGLAYLHGETSQATIVHRDIKALNILLASNLEAKISDFGLARL-----IQEDRSY---ISTRAAGTVGYLALEYAL--SGQFTEKADV
|  |  || | | |. .||   .   | |.|||  ||||  ....||.||||.|        |. .|   .  .  ||  |.. |.    .|| | | ||
WHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQLTKKTDV

YSFGILVLEILSGR
||||| .||.|.|.
YSFGIVLLEVLTGC

Kinase IRAK-Un_ax.AA TK 1-193 18 4.8e-40 131.41 In-house 8-389 (486) Show / Hide
Range on Protein: 1-193
Range on HMM: 8-389/486
Sequence Identity: 18% (72 aa)

GRGGFA---SVYKGVIDNH---------------------------FVAVKYLTS-SDLSDKARRD--------------FENEVSTIC--LLQHKNVVK
|.| |     ||||   ..                            |||| |.. .. |.....|              . .| .  |  |..|.|.|.
GEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVR

LFGFCSEK------------EHKLIVCEFIENGN----LSEALFSSPDKGLE------------------------------------------------
|.| |...            |. .|| |. ..|.    | . | ....|. .                                                
LYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKD

------------------------LNWTARYNICVGVAQGLAYLHGETSQAT---IVHRDIKALNILLASNLE-----------AKISDFG--------L
                        |.   .  .|. .|.|..|||    .     .||||. | |.|...|.            .||.|||        |
HPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVL

ARLIQEDRSYISTRAAGTVG-------------------------YLALEYALSGQ---------FTEKADVYSFGILVLEILS
|| |..|  | ...  || .                         ..| |  ....         ||.| ||.|||.|. ||..
ARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFT

Kinase IRAK-Un_ax.AA Dicty4 1-192 31 2e-38 125.86 In-house 8-211 (277) Show / Hide
Range on Protein: 1-192
Range on HMM: 8-211/277
Sequence Identity: 31% (64 aa)

GRGGFASVYKGVIDNHFVAVKYL--TSSDLSDKARRDFENEVSTICLLQHKNVVKLFGFCS----EKEHKLIVCEFIENGNLSEALFS---SPDKGLELN
|.|.|..||||      |||| |  .  ... .   .| .||.  | ..| |.... | |     ...  .|| |.   ||| . | .      .  .| 
GKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLD

WTARYN---ICVGVAQGLAYLHGETSQATIVHRDIKALNILLASNLEAKISDFGLARLIQEDRSYIS--TRAAGTVGYLALEYALSGQFTEKADVYSFGI
|. .     ..  .|.|...||.  .   |.|||.|. |.|   |. .|..||||....... .     . |.||... | |   .  ..||||||||||
WPLIKRAMRMAFDAARGMNWLHC--CNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADVYSFGI

LVLEIL
.  |||
VLWEIL

Kinase IRAK-Un_ax.AA Pkinase_Tyr 1-193 32 1.4e-37 127.88 Pfam 8-209 (270) Show / Hide
Range on Protein: 1-193
Range on HMM: 8-209/270
Sequence Identity: 32% (67 aa)

GRGGFASVYKGVID------NHFVAVKYLTSSDLSDKA--RRDFENEVSTICLL-QHKNVVKLFGFCS-EKEH--KLIVCEFIENGNLSEALFSS--PDK
|.| | .||||. .      .  |||| |   . ....  |.|| .|... . | .|.|.|.| | |. ..|.   .|| |. ..|.| . | .   ...
GEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQ

GLELNWTARYNICVGVAQGLAYLHGETSQATIVHRDIKALNILLASNLEAKISDFGLARLI-QEDRS-YISTRAAGTVGYLALEYALSGQFTEKADVYSF
 | . .    ..|. .|.|..||.       ..|||. | |.|...|. .||.||||||.|  .|   . .. .   .  .|.|    | ||.| ||.||
PLTMKD--LLQMCWQIAKGMEYLESKN----CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

GILVLEILS
|.|  ||..
GVLMWEIFT

Kinase IRAK-Un_ax.AA MLK 1-196 27 1.4e-35 120.96 In-house 8-234 (291) Show / Hide
Range on Protein: 1-196
Range on HMM: 8-234/291
Sequence Identity: 27% (63 aa)

GRGGFASVYKGVIDNHF-----VAVKYLTSSDLSDKAR-----RDFENEVSTICLLQHKN----VVKLFGFCSEKEH-KLIVCEFIENGNLSEALFSSPD
| |.| .|.||.  |       ||||  ...   ||..     .||| |.     |.|.|    .... | |.. ..  .|| |..|.| |.. | . ..
GSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARS

KGL----------ELNWTARYNICVGVAQGLAYLHGETSQATIVHRDIKALNILLAS------NLEAKISDFGLARLIQEDRSYISTRAAGTVGYLALEY
|.                   |... .|.|..||| .  . .|.|||.|  |||..       .. .||.|||..| ...      . .|||. . | | 
KWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMA-PKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYAWMAPEV

---ALSGQFTEKADVYSFGILVLEILSGRI
   . .....||.||.|.|..  |.|....
IQQFRCEKYSEKCDVWSWGVVLWEMLTREV

Kinase IRAK-Un_ax.AA Dicty4-Unclassified 1-194 33 1.9e-35 118.82 In-house 8-204 (263) Show / Hide
Range on Protein: 1-194
Range on HMM: 8-204/263
Sequence Identity: 33% (69 aa)

GRGGFASVYKGVIDNHFVAVKYLTSSDLSDKAR----RDFENEVSTICLLQHKNVVKLFGFC----SEKEHKLIVCEFIENGNLSEALF---SSPDKGLE
|.| |. |.||.     |||| . .   ..|.|     ||  ||    ..|| | ||. | |    | |    || ||.  ||| |      |  .. . 
GKGHFSKVHKGNWKGKDVAVKKFNEN--KFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQPIK

LNWTARYNICVGVAQGLAYLHGETSQATIVHRDIKALNILLASNLEAKISDFGLARLIQEDRSYISTRAAGTVGYLALEYALSGQFTEKADVYSFGILVL
|. |    .   .|||...||       ..|||||. |||.  .  .|| |||..| |  |  .  |  |||.   . |      .. |.||||....  
LDDTLIIKYAFDIAQGMQHLH----TRNFIHRDIKSSNILMDKHFNIKIADFGISRVI--DFNFNMTTIAGTPKWESPECLMHESYNQKSDVYSYAMMLY

EILSG
| . |
ELATG

Kinase IRAK-Un_ax.AA LRRK 1-196 24 4.1e-34 118.07 In-house 8-281 (351) Show / Hide
Range on Protein: 1-196
Range on HMM: 8-281/351
Sequence Identity: 24% (70 aa)

GRGGFA-SVYKGVIDN----------------------------HFVAVKYLTS----SDLSD-----------------------------KARRDFEN
|||||. .||..   .                              ||.| ..     .|  |                             .| | | .
GRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTID-NDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRAFREFRH

EVSTICLLQHKNVVKLFGFCSEKEHKLIVCEFIENGNLSEALFSSPDKGL-----ELNWTARYNICVGVAQGLAYLHGETSQAT--IVHRDIKALNILL-
||. .. |.| |.|.|.|||   ..  .| |.. .|.|.. |...   |.     ...|. .. | . .| |..|||     ..  |.||| |  |||| 
EVWIMSHLNHPNIVSLKGFCI--HPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHS----HNPPIIHRDLKSPNILLW

AS-----------NLEAKISDFGLARLIQEDRSYISTRAAGTVGYLALEYALSG---QFTEKADVYSFGILVLEILSGR-I
 |           .  |||.|||. |. | ... .  .  |. |..| |    .   ..|||.|.||||..  |.|... .
SSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHH

Kinase IRAK-Un_ax.AA Pkinase 1-195 27 9.4e-34 120.43 Pfam 8-209 (293) Show / Hide
Range on Protein: 1-195
Range on HMM: 8-209/293
Sequence Identity: 27% (57 aa)

GRGGFASVYKGV--IDNHFVAVKYLTSSDLSDKARRDFEN--EVSTICLLQHKNVVKLFGFCSEKEHKLIVCEFIENG----NLSEALFSSPDKGLEL--
|.|.|..|||..   ... |||| .  .. ... ..   .  |..    |.|.|.|.|.... .| |  .| |. |.|     |.. .    ...  .  
GSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--WRHGCFYF

NWTARYNICVGVAQGLAYLHGETSQATIVHRDIKALNILLASNLEA----KISDFGLARLIQEDRSYISTRAAGTVGYLALEYAL-SGQFTEKADVYSFG
 .    ...  ...||.|.| .     |.|||.|  |||. .| .     ||.|||||..... ..   |  .|| .|.| |  . .   . |.|..|.|
SEWECKFYMYQILRGLEYCHSM----GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCG

ILVLEILSGR
... | |.||
CILYEMLCGR

Kinase IRAK-Un_ax.AA STE 1-195 19 4e-32 110.76 In-house 8-265 (359) Show / Hide
Range on Protein: 1-195
Range on HMM: 8-265/359
Sequence Identity: 19% (52 aa)

GRGGFASVYKGVID-----------------NHFVAVKYLTSSDLS---------------DKARRDFENEVSTICLLQ--HKNVVKLFGFCSEK-----
|.|.| .|||..                   . ..|.| .  .. .               .. . ....|...   ..  |.|.|| .| .  .     
GKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHK

--EHKLIVCEFIENGNLSEALFS--SPDKGLE----------LNWTARYNICVGVAQG-LAYLHGETSQATIVHRDIKALNILLASNLEAKISDFGLARL
  ..  |. |....| |.. . .  .. |.|            .. |.  ||. . .| |.|||       |.|||||. ||||     .|..|||..  
NDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAY--ICRQILKGLLYYLHSHH----IIHRDIKPANILL-----VKLCDFGVCGQ

IQE---------------DRSYISTRAAGTVGYLALEYALS------GQFTEKADVYSFGILVLEILSGR
...               ...  ..  .||  . | |  .       .. ..|.|..|.|....| . |.
LTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK

Kinase IRAK-Un_ax.AA LISK 1-151 29 1.6e-31 99.54 In-house 3-159 (296) Show / Hide
Range on Protein: 1-151
Range on HMM: 3-159/296
Sequence Identity: 29% (47 aa)

GRGGFASVYKGVID--NHFVAVKYLTS----SDLSDKARRDFENEVSTICLLQHKNVVKLFGFCSE-KEHKLIVCEFIENGNLSEALFSSPDKGLELNWT
|.|.|..||||     .  .|.| ...    ... . ... .. || .. .|.|.|.|. .| | . . .  || |.|. |.| . |.... .   | |.
GKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPE-YQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPWP

ARYNICVGVAQGLAYLHGETSQATIVHRDIKALNILLASN----LEAKISDFGLARLIQEDR
 | .| ...|.|..|||       |.||| |. |.|.  |     ..|. |||.||......
QRVKIALDIACGMSYLH----SMNIIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCEN

Kinase IRAK-Un_ax.AA TyrKc 1-270 25 1.3e-29 105.61 SMART 8-280 (280) Show / Hide
Range on Protein: 1-270
Range on HMM: 8-280/280
Sequence Identity: 25% (76 aa)

GRGGFASVYKGVIDNHFVAVKYLTSSDLSDKARRDFENEVSTICLL--QHKNVVKLFGFCSEK-------EHKLIVCEFIENGNLSEALFSSPDKGLELN
|.| |  ||||. .   |||| | ..      |.|| .| .  | |  .|.|.|.|.| |...       |  .|| |. ..|.| . | .. .|   |.
GEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK---LC

WTARYNICVGVAQGLAYLHGETSQATIVHRDIKALNILLASNLEAKISDFGLARLIQED-------RSYI-----STRAAGTVGYLALEYALSGQFTEKA
.    ..|. .|.| .|||       ..|||. | |.|...|. .|||||||.| | .|         |      ....   .  .|.|    | ||.| 
MKDLLSFCWQIACGMEYLHSK----NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKS

DVYSFGILVLEILSGRISMDFTL---SDGDSFLLERVTWNVFQSGHLLEMIDKRLDVDDERDIHEM------ERVFLVALHCTHASGSRRPSMFRVVGML
||.|||..  ||.. .  .            ..  .   .  ..|. ..  .  .         .|      . .. . . | |.  . ||..  ..  .
DVWSFGVCMWEIFT-YGQQPYPGMIQQ----MMSNQEVIEYVKQGYRMPQPPNDY---------PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF





Kinase IRAK-Un_ax.AA S_TKc 1-247 23 1.2e-22 82.43 SMART 8-231 (231) Show / Hide
Range on Protein: 1-247
Range on HMM: 8-231/231
Sequence Identity: 23% (62 aa)

GRGGFASVYKGVIDN--HFVAVKYLTSSDLSDKARRDFENEVSTICLLQHKNVVKLFGFCSEKEHKLIVCEFIEN--GNLSEALFSSPDKG----LELNW
|.|.|..|||..  .  . ||.| .          .....|..     .|.|.|||.... . .|  .| |....  |.| . . . . .|    .   .
GKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-H

TARYNICVGVAQGLAYLHGETSQATIVHRDIKALNILLASNLEAKISDFGLARLIQEDRSYISTRAAGTVGYLALEYALSGQFTE-KADVYSFGILVLEI
...|  .  ....|.|.|   |.  |.|||.|  |||| .  . ||.||||||..        |   ||  |.| |     ...  |.|..|.|... | 
ARFY--MYQICCALEYCH---SH-GIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

LSGRISMDFTLSDGDSFLLERVTWNVFQSGHLLEMIDKRLDVD-----DERDIHEME-----RVFL
|.|.   .      .  .....      |  ....|.| |..|        .. ..|       ..
LCGYPPFP-----QMQMMFKKIG-----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase IRAK-Un_ax.AA LISK 176-191 56 5.1e-05 12.03 In-house 217-232 (296) Show / Hide
Range on Protein: 176-191
Range on HMM: 217-232/296
Sequence Identity: 56% (9 aa)

TEKADVYSFGILVLEI
.|..||.||||...||
DESCDVFSFGIVLCEI

Kinase IRAK-Un_ax.AA TK 242-270 17 0.036999 2.17 In-house 447-486 (486) Show / Hide
Range on Protein: 242-270
Range on HMM: 447-486/486
Sequence Identity: 17% (7 aa)

M-----------ERVFLVALHCTHASGSRRPSMFRVVGML
|           | .... . | |.  ..||..  .. .|
MRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL