Gene IRAK-Un_br-2 (S.moellendorffii)
IRAK-Un_br-2
Species: S.moellendorffii
Alias: IRAK-Un_br-2
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| IRAK-Un_br-2.AA | Protein | None | 312 | None | Fasta, JSON |
| IRAK-Un_br-2.NA | RNA | None | 939 | None | Fasta, JSON |
| IRAK-Un_br-2.kin_dom | Protein Kinase Domain | None | 110 | None | Fasta, JSON |
Protein domains of IRAK-Un_br-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | IRAK-Un_br-2.AA | TKL | 34-238 | 19 | 2.5e-28 | 99.11 | In-house | 116-364 (364) | Show / Hide |
Range on Protein: 34-238 Range on HMM: 116-364/364 Sequence Identity: 19% (51 aa) VYEIQANGS-LDRLLYGRSRDRPPLDWATRVRIATDAARGLAFLHERSP-----TKLMYKDFRTFNVHVDKELR--------------ARLMGYGFTQSL |.| .|| |..|. | |.|.| |.|||...|| . | .. . | . |. ||. .. . . .|. ... VMEYCPGGSLLHYLH-----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFM EEKILTRCCS---------------LCLKV--AAYAAPELLQRGTQ-------------SLPSPKSNVWSFGVVLLEILTGRQNRDEMFAVEEQDLVGWT ... . . .. .. .. |||.|. .. . |.|. |.|||.|| ||||... .... . SQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR------PYYDYPYMPMI APYLANDKKLFLVVDPELKGMFP------------ARSVSLFAKLAAQCLQRDPAARPSMDQVVQSL . . . . .|.| |. | ..||. .| . || .|||...... | FQDP-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL |
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| Kinase | IRAK-Un_br-2.AA | IRAK | 146-238 | 22 | 4.3e-11 | 35.7 | In-house | 202-317 (317) | Show / Hide |
Range on Protein: 146-238 Range on HMM: 202-317/317 Sequence Identity: 22% (27 aa) SPKSNVWSFGVVLLEILTGR-QNRDE--------MFAVEEQDLVG-----------------WTAPYLANDKKLFLVVDPELKGMFPARSVSLFAKLAAQ ..|. | |||.||||.|||. . .|. |. . | | || . . ..|. ..... | .. .. .| . TKKTDVYSFGIVLLEVLTGCRAVYDDRPEHYYLKDLCEEIMEEWGHLDSCQSTLWVGVATDAWAAPRRMQIYEKFID---HRMPPCPPNMEKEMCQCACC CLQRDPAARPSMDQVVQSL |. . . |..|..|.|.| CGHHRANRRCDMAWVMQQL |
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| Kinase | IRAK-Un_br-2.AA | TKL-Unique | 56-166 | 25 | 7.3e-11 | 34.71 | In-house | 106-226 (290) | Show / Hide |
Range on Protein: 56-166 Range on HMM: 106-226/290 Sequence Identity: 25% (31 aa) PLDWATRVRIATDAARGLAFLHERSPTKLMYKDFRTFNVHVDKE-----LRARLMGYGFTQSLEEKILTRCC-------SLCLKVAAYAAPELLQRGTQS .|... ||..| |.|.|. .|| ..|. . | .. |. || . ..... . |. .. . . . .. . ..|||.| . . KLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNF-C LPSPKSNVWSFGVVLLEILTGRQ . | || |.|||.|| ||.|. . QYSEKSDVYSFGIVLWEIATRKI |
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| Kinase | IRAK-Un_br-2.AA | Pkinase | 131-238 | 18 | 1.6e-10 | 38.25 | Pfam | 177-293 (293) | Show / Hide |
Range on Protein: 131-238
Range on HMM: 177-293/293
Sequence Identity: 18% (26 aa)
YAAPELLQRGTQSLPSPKSNVWSFGVVLLEILTGRQNRDEMFAVEEQDLVGWTAPYLAN--------DKKLFLVVDPELKGMFPARSV------------
|.|||... ... .||. .||.|..| | |.|| |. ....... .|.|. .| .
YMAPEVIR--GGQYYGPKVDMWSCGCILYEMLCGR------------------PPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFH
-------SLFAKLAAQCLQRDPAARPSMDQVVQS--L
. . .. ||..||. ||. .|..|. .
WTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
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| Kinase | IRAK-Un_br-2.AA | LRRK | 40-81 | 25 | 1e-09 | 30.55 | In-house | 139-185 (351) | Show / Hide |
Range on Protein: 40-81 Range on HMM: 139-185/351 Sequence Identity: 25% (12 aa) NGSLDRLLYGRSRDR-----PPLDWATRVRIATDAARGLAFLHERSP .|.|...| ...|. . ..| .. .||.. |.|...|| ..| HGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNP |
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| Kinase | IRAK-Un_br-2.AA | TK-Unique | 133-163 | 46 | 1.7e-08 | 25.55 | In-house | 204-234 (294) | Show / Hide |
Range on Protein: 133-163 Range on HMM: 204-234/294 Sequence Identity: 46% (15 aa) APELLQRGTQSLP-SPKSNVWSFGVVLLEILT ||| |.. . ..||.||||||.. ||.| APESLKCY-HGMYHTTKSDVWSFGVLMWEIFT |
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| Kinase | IRAK-Un_br-2.AA | IRAK | 21-81 | 31 | 2e-08 | 26.15 | In-house | 68-130 (317) | Show / Hide |
Range on Protein: 21-81 Range on HMM: 68-130/317 Sequence Identity: 31% (20 aa) ILGFSFTTDEKLVVYEIQANGSLDRLLYGRSRDRPP--LDWATRVRIATDAARGLAFLHERSP ..|... ... ||. .|||| | .. . || | | .|. |. .|.|. |||. .| LYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQCPPKPLSWHQRCSICWGTACGIQFLHQNHP |
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| Kinase | IRAK-Un_br-2.AA | TK | 133-163 | 40 | 5.8e-08 | 21.97 | In-house | 353-389 (486) | Show / Hide |
Range on Protein: 133-163 Range on HMM: 353-389/486 Sequence Identity: 40% (15 aa) APELLQRGT------QSLPSPKSNVWSFGVVLLEILT ||| |. .. ..|| ||||||.. ||.| APECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFT |
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| S_TKc | IRAK-Un_br-2.AA | S_TKc | 4-243 | 16 | 6.9e-08 | -61.23 | SMART | 18-231 (231) | Show / Hide |
Range on Protein: 4-243
Range on HMM: 18-231/231
Sequence Identity: 16% (44 aa)
IEHVK----------------EIVCLR--DAHLSRILGFSFTTDEKLVVYEIQAN--GSLDRLLYGRSRDRPP--LDWATRVRIATDAARGLAFLHERSP
|.| || .|. .. ..... . |. .| | . |.| ... | | ... .. . ... ...|...|..
CRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH--
TKLMYKDFRTFNVHVDKELRARLMGYGFTQSLEEKILTRCCSLCLKVAAYAAPELLQRGTQSLPSP-KSNVWSFGVVLLEILTGRQ---NRDEMFAVEEQ
. .. | |. .|. . . |. | . . | |||.| .. |. .||.|..| | |.|. . ..|| .
-GIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL------GYGKCKCDWWSCGCILYEMLCGYPPFPQMQMMFKKIG-
DLVGWTAPYLANDKKLFLVVDPELKGMFPARSVSLFAKLAAQCLQRDPAARPSMDQVVQ----SLEHVQA
| .. . .|||.||. ||. .. | |
-------------------------------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| TyrKc | IRAK-Un_br-2.AA | TyrKc | 4-238 | 15 | 8.8e-08 | -96.84 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 4-238 Range on HMM: 1-280/280 Sequence Identity: 15% (47 aa) IEHVK----------------------------------EIVCLRDA-----HLSRILGFSFTT-------DEKLVVYEIQANGSLDRLLYGRSRDRPPL |. | |. .. .. |..| . . ..| | ..|.|. | . .. | ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK---L DWATRVRIATDAARGLAFLHERSPTKLMYKDFRTFNVHVDKELRARLMGYGFTQSLEEK--------ILTR----CCS--LCLKVAAYAAPELLQRGTQS ... . .....|.| ..||.. .. | . |. |....... | . .... . .. | .. ||| . . CMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIR---WMAPECI---NYG LPSPKSNVWSFGVVLLEILT-GRQNRDEM----FAVEEQDLVGWTAPYLANDKKLFLVVDPELKGM-FPARSVSLFAKLAAQCLQRDPAARPSMDQVVQS ..|| ||||||.. ||.| | | .| .| |. . . . ... | | . . .. || ..||. ||.. .... KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQE------VIEYVKQGYRMPQPPNDY-P-MSF-VCCPDEMYQIMKQCWHEDPEDRPTFSEIHEC L . F |
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| Kinase | IRAK-Un_br-2.AA | DRK | 213-240 | 35 | 3.2e-07 | 20.53 | In-house | 231-258 (258) | Show / Hide |
Range on Protein: 213-240 Range on HMM: 231-258/258 Sequence Identity: 35% (10 aa) FAKLAAQCLQRDPAARPSMDQVVQSLEH ...| |. || ||||..... || YIQLMNDCWNEDPQHRPSMQECLERLEA |
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| Kinase | IRAK-Un_br-2.AA | Dicty4 | 213-240 | 36 | 4.5e-07 | 19.83 | In-house | 248-277 (277) | Show / Hide |
Range on Protein: 213-240 Range on HMM: 248-277/277 Sequence Identity: 36% (11 aa) FAKLAAQCLQRDPAARPSMDQVVQS--LEH ...| . |. || |||. ...| ||| WKHLIQWCWDHDPQHRPSFEEIIQRRILEH |
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| Kinase | IRAK-Un_br-2.AA | MLK | 213-238 | 50 | 5.1e-07 | 20.54 | In-house | 266-291 (291) | Show / Hide |
Range on Protein: 213-238 Range on HMM: 266-291/291 Sequence Identity: 50% (13 aa) FAKLAAQCLQRDPAARPSMDQVVQSL ..|| || . ||. |||..|.|| | WKKLMKQCWNQDPHKRPSFRQIVQHL |
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| Kinase | IRAK-Un_br-2.AA | MLK | 129-165 | 45 | 3e-06 | 17.61 | In-house | 197-233 (291) | Show / Hide |
Range on Protein: 129-165 Range on HMM: 197-233/291 Sequence Identity: 45% (17 aa) AAYAAPELLQRGTQSLPSPKSNVWSFGVVLLEILTGR .|. ||| .|. . | |. |||.|||| |.||.. YAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTRE |
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| Kinase | IRAK-Un_br-2.AA | TK | 210-238 | 22 | 3e-06 | 16.17 | In-house | 447-486 (486) | Show / Hide |
Range on Protein: 210-238 Range on HMM: 447-486/486 Sequence Identity: 22% (9 aa) V-----------SLFAKLAAQCLQRDPAARPSMDQVVQSL . ... | || ..||. ||...|... | MRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL |
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| Kinase | IRAK-Un_br-2.AA | TK | 13-79 | 8 | 1.2e-05 | 14.09 | In-house | 100-253 (486) | Show / Hide |
Range on Protein: 13-79
Range on HMM: 100-253/486
Sequence Identity: 8% (13 aa)
LRDAHLSRILGFSFTTDEK------------LVVYEIQANGS----LDRLLYGRSRDRPP----------------------------------------
.. .. |..| .. ..| ..| | ..|. |. | ..... .
GHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQD
--------------------------------LDWATRVRIATDAARGLAFLHER
|. .... .. ..|.|...||..
YDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSK
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| Kinase | IRAK-Un_br-2.AA | UTK | 32-79 | 32 | 1.3e-05 | 15.19 | In-house | 86-137 (296) | Show / Hide |
Range on Protein: 32-79 Range on HMM: 86-137/296 Sequence Identity: 32% (17 aa) LVVYEIQANGSLDRLLYGRSRDRP-PLDWAT---RVRIATDAARGLAFLHER ..|.| ..||.|. .| ... | . .| | |. | | |||...||.. MIVTEYMENGDLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSC |
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| Kinase | IRAK-Un_br-2.AA | Dicty4 | 56-81 | 44 | 1.4e-05 | 14.78 | In-house | 105-133 (277) | Show / Hide |
Range on Protein: 56-81 Range on HMM: 105-133/277 Sequence Identity: 44% (13 aa) PLDWATRVR---IATDAARGLAFLHERSP .||| .. | .| |||||.. ||.. | KLDWPLIKRAMRMAFDAARGMNWLHCCNP |
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| Kinase | IRAK-Un_br-2.AA | UTK | 133-164 | 53 | 2.2e-05 | 14.36 | In-house | 207-236 (296) | Show / Hide |
Range on Protein: 133-164 Range on HMM: 207-236/296 Sequence Identity: 53% (17 aa) APELLQRGTQSLPSPKSNVWSFGVVLLEILTG ||| | .| .. || |||||||. ||.|. APEALTHHT--RFTTKSDVWSFGVVCWEIWTW |
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| Kinase | IRAK-Un_br-2.AA | DRK | 57-81 | 32 | 0.000112 | 11.81 | In-house | 95-119 (258) | Show / Hide |
Range on Protein: 57-81 Range on HMM: 95-119/258 Sequence Identity: 32% (8 aa) LDWATRVRIATDAARGLAFLHERSP .|| . ... |.|.|. .|| . | MDWPLMKQMMFDCAKGMIYLHCCNP |
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| Kinase | IRAK-Un_br-2.AA | TKL-Unique | 219-238 | 45 | 0.000113 | 12.61 | In-house | 271-290 (290) | Show / Hide |
Range on Protein: 219-238 Range on HMM: 271-290/290 Sequence Identity: 45% (9 aa) QCLQRDPAARPSMDQVVQSL || .|| ||| |... .| QCWHHDPSQRPSFDEIIHRL |
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| Kinase | IRAK-Un_br-2.AA | TK-Unique | 219-238 | 40 | 0.000305 | 10.67 | In-house | 275-294 (294) | Show / Hide |
Range on Protein: 219-238 Range on HMM: 275-294/294 Sequence Identity: 40% (8 aa) QCLQRDPAARPSMDQVVQSL .|.|..| ||| .|... | SCWQWEPEERPSFRQIKHRL |
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| Kinase | IRAK-Un_br-2.AA | MLK | 39-81 | 28 | 0.000446 | 10.19 | In-house | 93-145 (291) | Show / Hide |
Range on Protein: 39-81 Range on HMM: 93-145/291 Sequence Identity: 28% (15 aa) ANGSLDRLLYG-RSRDRP---------PLDWATRVRIATDAARGLAFLHERSP ..||| ..|.| || . | . ...|.. |||...||. | EGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAP |
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| Kinase | IRAK-Un_br-2.AA | LRRK | 219-240 | 40 | 0.001001 | 9.04 | In-house | 330-351 (351) | Show / Hide |
Range on Protein: 219-240 Range on HMM: 330-351/351 Sequence Identity: 40% (9 aa) QCLQRDPAARPSMDQVVQSLEH .| | || ||.. |.|. |. HCWQHDPKKRPHFSQIVKRLSQ |
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| Kinase | IRAK-Un_br-2.AA | UTK | 215-238 | 33 | 0.001054 | 8.55 | In-house | 273-296 (296) | Show / Hide |
Range on Protein: 215-238 Range on HMM: 273-296/296 Sequence Identity: 33% (8 aa) KLAAQCLQRDPAARPSMDQVVQSL .| .| . ||. ||.....|| . RLMHRCWHYDPQERPDFEDLVQQM |
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| Kinase | IRAK-Un_br-2.AA | Pkinase_Tyr | 219-238 | 35 | 0.001592 | 12.56 | Pfam | 251-270 (270) | Show / Hide |
Range on Protein: 219-238 Range on HMM: 251-270/270 Sequence Identity: 35% (7 aa) QCLQRDPAARPSMDQVVQSL || . ||. ||.. .... | QCWHYDPEDRPTFSEIHEQL |
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| Kinase | IRAK-Un_br-2.AA | Pkinase_Tyr | 39-79 | 21 | 0.021376 | 8.74 | Pfam | 90-130 (270) | Show / Hide |
Range on Protein: 39-79 Range on HMM: 90-130/270 Sequence Identity: 21% (9 aa) ANGSLDRLLYGRSRDRPPLDWATRVRIATDAARGLAFLHER ..|.|. | .. |..||. . . .... |.|...|... PHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESK |
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| Kinase | IRAK-Un_br-2.AA | Pkinase_Tyr | 151-166 | 64 | 0.026571 | 8.42 | Pfam | 197-213 (270) | Show / Hide |
Range on Protein: 151-166 Range on HMM: 197-213/270 Sequence Identity: 64% (11 aa) VWSFGVVLLEILT-GRQ ||||||.. ||.| |.| VWSFGVLMWEIFTYGEQ |
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| Kinase | IRAK-Un_br-2.AA | Dicty4 | 148-164 | 64 | 0.068482 | 2.29 | In-house | 197-213 (277) | Show / Hide |
Range on Protein: 148-164 Range on HMM: 197-213/277 Sequence Identity: 64% (11 aa) KSNVWSFGVVLLEILTG |. | ||| || ||||. KADVYSFGIVLWEILTR |
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| Kinase | IRAK-Un_br-2.AA | DRK | 148-163 | 50 | 0.188594 | 0.72 | In-house | 182-197 (258) | Show / Hide |
Range on Protein: 148-163 Range on HMM: 182-197/258 Sequence Identity: 50% (8 aa) KSNVWSFGVVLLEILT | |.||..|| |..| KADVYSFAIVLWECVT |
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| Kinase | IRAK-Un_br-2.AA | Pkinase | 40-80 | 12 | 3.292922 | 1.82 | Pfam | 84-128 (293) | Show / Hide |
Range on Protein: 40-80 Range on HMM: 84-128/293 Sequence Identity: 12% (6 aa) NG----SLDRLLYGRSRDRPPL--DWATRVRIATDAARGLAFLHERS .| .| ... . ... .. .. . .... .|||...|... GGLYVMDLFDYIST--WRHGCFYFSEWECKFYMYQILRGLEYCHSMG |
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