IRAK-Un_ag

Species: S.moellendorffii
Alias: IRAK-Un_ag
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
IRAK-Un_ag.AA Protein None 422 None Fasta, JSON
IRAK-Un_ag.NA RNA None 1269 None Fasta, JSON
IRAK-Un_ag.kin_dom Protein Kinase Domain None 376 None Fasta, JSON

Protein domain

Protein domains of IRAK-Un_ag.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IRAK-Un_ag.AA CMGC 30-405 18 1.9e-101 334.2 In-house 1-513 (513) Show / Hide
Range on Protein: 30-405
Range on HMM: 1-513/513
Sequence Identity: 18% (110 aa)

YAVLDPIGSGAYSDVYHGKR--------------RDDGLHVALK------EVHDGK----------SSSRELAALQLL----------------TNSSHV
| ....||.|.|. || ..               .... .||.|      . ...|          .. ||.  |. |                 .  ..
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VQLLDHVWLHP-----------------GVLLVLEFLPGSLAEVIEERK-------EIPFQEFE------------ARNWM------EQILKAVA--ECH
|.|.|..  .                   . || |... .|...|.. .        .|. | .             .. |       |||....   ||
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

SAG--ILHRDLKPSNLLISSD--------------------GVLKVADFGTALVLPVE-------------NVEEALKSAATSSEQQPETMVPAQIRGSK
|..  |.||||||.|.||...                    |.||..||| |  . ..             ||                           
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNK-------------------------

SYDRLEIEDSGTEVSPRVSDAEEEEDGARSRNDRYSDGEWEKTSNKDSDWYKSSKMWWCSSQVGNDDFRGEMTDCVGTRWYKAPELLYGS---------T
                                                                .|. .  .|. | ||||.|||.| |.         .
----------------------------------------------------------------DDKPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSM

SYNFAVDLWAVGCILGELIQG--------EPLFPGASD-----------IDQLSRVVRVLGVPN---------------ETIWPGISSLPDYDK------
 |. ..| |.||||..|...|        .||||| |.           |||| . ..||| |.               | .||....||.|.|      
HYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKLPWYNKFPKKWN

-------ICF-----------NDDRPPVTLARILPR-----------------------------------ASGEALRLIEKLLVYDPASRLSASQALSH
       ..               .|| .. .. |.                                   .. .|. |..|.|.|||. |..|.|||.|
WQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQH

EFF
..|
PYF

Kinase IRAK-Un_ag.AA S_TKc 30-405 22 3.8e-83 283.47 SMART 1-231 (231) Show / Hide
Range on Protein: 30-405
Range on HMM: 1-231/231
Sequence Identity: 22% (87 aa)

YAVLDPIGSGAYSDVYHGKRRDDGLHVALKEVHDGKSSSRELAALQLLTNSSHVVQLLDHVWLHPGVLLVLEFLPG---SLAEVIEERKE----IPFQEF
| .|..||.||.. || .. ...| .||.|...  ..  ||.. |.   .  ..|.|.|.      . .|.|...|   .| ..|..|.      || | 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-

EARNWMEQILKAVAECHSAGILHRDLKPSNLLISSDGVLKVADFGTALVLPVENVEEALKSAATSSEQQPETMVPAQIRGSKSYDRLEIEDSGTEVSPRV
.|| .| ||..|.. ||| ||.||||||.|.|...  ..|..||| | .|                                                  
HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------------------------------------------------

SDAEEEEDGARSRNDRYSDGEWEKTSNKDSDWYKSSKMWWCSSQVGNDDFRGEMTDCVGTRWYKAPELLYGSTSYNF-AVDLWAVGCILGELIQGEPLFP
                                                      | ..||.|| |||.|    .|.. ..| |..|||| |.. |.|.||
------------------------------------------------------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLCGYPPFP

GASDIDQLSRVVRVLGVPNETIWPGISSLPDYDKICFNDDRPPVTLARILPRASGEALRLIEKLLVYDPASRLSASQALS-------HEFF
   ..... ....                                        | ||. .|.|.|..||. |..| .||        |..|
---QMQMMFKKIG----------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase IRAK-Un_ag.AA MAPK 130-405 25 1.2e-64 221.14 In-house 123-328 (328) Show / Hide
Range on Protein: 130-405
Range on HMM: 123-328/328
Sequence Identity: 25% (74 aa)

QILKA--VAECHSAGILHRDLKPSNLLISSDGVLKVADFGTALVLPV-ENVEEALKSAATSSEQQPETMVPAQIRGSKSYDRLEIEDSGTEVSPRVSDAE
|||..  .   |||...||||||||.|. ... ||..||| | ..   .. ..  . . ..   |                                   
QILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDP-HC-F-Q-----------------------------------

EEEDGARSRNDRYSDGEWEKTSNKDSDWYKSSKMWWCSSQVGNDDFRGEMTDCVGTRWYKAPELLYG--STSYNFAVDLWAVGCILGELIQ-GEPLFPGA
                                              .. ||. | |||| |||.. .  .. |. ||| |.||||..|... . ||||| 
----------------------------------------------KMHMTEYVATRWYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGK

SDIDQLSRVVRVLGVPNETIWPGIS-S-LP-DYDKIC-FNDDRPPVTLARILPR----ASGEALRLIEKLLVYDPASRLSASQALSHEFF
. |||. ... ||| | |  .  |. |  . .| . . ..  .|..... ..|     |. .|. |.||.|| ||  |... .||.|..|
DYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQAIDLLEKMLVFDPDKRITVEEALQHPYF

Kinase IRAK-Un_ag.AA CDK 275-405 40 5.7e-62 196.98 In-house 175-284 (284) Show / Hide
Range on Protein: 275-405
Range on HMM: 175-284/284
Sequence Identity: 40% (55 aa)

EMTDCVGTRWYKAPELLYGSTSYN--FAVDLWAVGCILGELIQ---GEPLFPGASDIDQLSRVVRVLGVPNETIWPGISSLPDYDKICFNDDRPPVTLAR
..|  | |.|| ||||| ||. |.   ..|.|.||||..|...   ..||||| |.|||| .. |..| |.| .|||...||||                
TYTHEVVTLWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY----------------

ILPRASGEALRLIEKLLVYDPASRLSASQALSHEFF
           |..|.|.|||. |.||.|||.|..|
----------DLLNKMLCYDPKKRISAEQALQHPYF

Kinase IRAK-Un_ag.AA CDK7 277-405 41 1.5e-60 159.77 In-house 160-288 (288) Show / Hide
Range on Protein: 277-405
Range on HMM: 160-288/288
Sequence Identity: 41% (54 aa)

TDCVGTRWYKAPELLYGSTSYNFAVDLWAVGCILGELIQGEPLFPGASDIDQLSRVVRVLGVPNETIWPGISSLPDYDKICFNDDRPP--VTLARILPRA
|  | |||| |||||.|  .|  .||.|.||||. ||.   | .|| ||||||.|. . || |.|  ||......||  | | |  ..  . |  |   |
THQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELMLRVPYLPGDSDIDQLTRIFQTLGTPTEEEWPNMCCMMDY--IKFKDFPGYSRTPLRHIFTAA

SGEALRLIEKLLVYDPASRLSASQALSHEFF
| ..| |.....  .|  |....|.|....|
SDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF

Kinase IRAK-Un_ag.AA CCRK 280-405 53 3.6e-57 196.1 In-house 161-285 (285) Show / Hide
Range on Protein: 280-405
Range on HMM: 161-285/285
Sequence Identity: 53% (68 aa)

VGTRWYKAPELLYGSTSYNFAVDLWAVGCILGELIQGEPLFPGASDIDQLSRVVRVLGVPNETIWPGISSLPDYDKICFNDDRPPVTLARILPRASGEAL
| ||||.|||||||   |   |||||||||.|||. . |.|||  ||.||  |.|.|| |.. .||..  |||| || | .. ||. | ...| || .||
VATRWYRAPELLYGARQYDQGVDLWAVGCIMGELLNNSPIFPGENDIEQLCCVLRILGTPTPKVWPEMKDLPDYNKISFKEQ-PPMPLEQVVPDASPQAL

RLIEKLLVYDPASRLSASQALSHEFF
 |... ||| |  |..||||| |..|
DLLKQFLVYPPRQRIAASQALLHQYF

Kinase IRAK-Un_ag.AA CDC2 280-405 40 6.6e-53 160.67 In-house 166-301 (301) Show / Hide
Range on Protein: 280-405
Range on HMM: 166-301/301
Sequence Identity: 40% (56 aa)

VGTRWYKAPELLYGSTSYNFAVDLWAVGCILGEL---IQGEPLFPGASDIDQLSRVVRVLGVPNETIWPGISSLPDYDKI--CFNDDRPPVTLARILPR-
| |.|| |||.| |.  |...||.|..|||. |.   .. .|||.| | |||| .. |.|| ||| .|||...||||     ...    |  | .|.|. 
VVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNTFPRWK----PQDLSKICPNN

--------ASGEALRLIEKLLVYDPASRLSASQALSHEFF
        .  |.. |....|.|||. |.|| .||.| .|
QKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQHPYF

Kinase IRAK-Un_ag.AA CDK5 280-405 37 7.9e-49 152.15 In-house 159-287 (287) Show / Hide
Range on Protein: 280-405
Range on HMM: 159-287/287
Sequence Identity: 37% (49 aa)

VGTRWYKAPELLYGSTSYNFAVDLWAVGCILGELI-QGEPLFPGASDIDQLSRVVRVLGVPNETIWPGISSLPDYD-KICFNDDRPPVT-LARILPRASG
| | || .|  | ||  |.  .|.| .|||. |..  | |||||... ||| |. ...| |.|  ||.|. ||||  ..   . .|. . .. | |. ..
VVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGRPLFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDE

EALRLIEKLLVYDPASRLSASQALSHEFF
. . | .|.|...|. |.|| .|| | .|
KGMDLLQKMLQCNPNQRISAKAALHHPYF

Kinase IRAK-Un_ag.AA PITSLRE 277-405 40 6.2e-48 165.57 In-house 164-295 (295) Show / Hide
Range on Protein: 277-405
Range on HMM: 164-295/295
Sequence Identity: 40% (54 aa)

TDCVGTRWYKAPELLYGSTSYNFAVDLWAVGCILGELIQGEPLFPGASDIDQLSRVVRVLGVPNETIWPGISSLPDYDKIC-FNDDRPPVTLARILP---
| || | || ||||| |.  |  .||.| ||||..|.|...|||.| |.|||. ..   .| |.| ||||...||   ..  | .   . .| .. |   
TPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFAEFITMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNNFPHYP-YNNLRKRFPAEN

RASGEALRLIEKLLVYDPASRLSASQALSHEFF
. |  .. |  ..| |.|. |..||.|| |..|
HISDTGFDLLNQMLTYNPKNRITASDALKHPWF

Kinase IRAK-Un_ag.AA CDK-Unclassified 280-405 36 4e-46 149.65 In-house 199-324 (324) Show / Hide
Range on Protein: 280-405
Range on HMM: 199-324/324
Sequence Identity: 36% (47 aa)

VGTRWYKAPELLYGSTSYNFAVDLWAVGCILGELIQGEPLFPGASDIDQLSRVVRVLGVPNETIWPGISSLPDYDKICFNDDRPPV--TLARILPRASGE
| ||||.||||| ||  |. .|| |..|||. |..|| |.|.| ..|.|.. . ..|| |.|  || ....||| || |.   .    ..      ||. 
VSTRWYRAPELLFGSKCYDTGVDIWSFGCIYAEWFQGKPIFQGRTEIEQMHHIFKMLGTPCEDMWPDWRYMPDYCKIFFKYKQKFHWWNRFPKCKHASE-

ALRLIEKLLVYDPASRLSASQALSHEFF
 . ..  ...|.|  |......|.|. |
-NNCEFQMVMYQPYNRWKCMEILQHPWF

Kinase IRAK-Un_ag.AA RCK 277-405 43 7.4e-45 140.08 In-house 171-298 (298) Show / Hide
Range on Protein: 277-405
Range on HMM: 171-298/298
Sequence Identity: 43% (56 aa)

TDCVGTRWYKAPELLYGSTSYNFAVDLWAVGCILGELIQGEPLFPGASDIDQLSRVVRVLGVPNETIWPGISSLPDYDKICFNDDRPPVTLARILPRASG
|| |.|||| |||.|  .| ||  .|.||||||  ||    |||||.| |||.   . |.| || ..||  . |     . | .   .. |  ..|..| 
TDYVSTRWYRAPECLLRCTYYNSPMDIWAVGCIMYELYMLRPLFPGSSEIDQIFKICKVMGTPNKKDWPDGYKLASQMNFNFPQCK-GMPLKQLIPNCSQ

EALRLIEKLLVYDPASRLSASQALSHEFF
... |.||.| .||  | .|.||| | .|
DCIELMEKMLQWDPQKRITAQQALQHPYF

Kinase IRAK-Un_ag.AA Pkinase 30-167 31 2.3e-40 143.78 Pfam 1-157 (293) Show / Hide
Range on Protein: 30-167
Range on HMM: 1-157/293
Sequence Identity: 31% (49 aa)

YAVLDPIGSGAYSDVYHGKRRDDGLHVALKEVHDGKSSS---------RELAALQLLTNSSHVVQLLDHVWLHPGVLLVLEFLPG-----SLAEVIEERK
| .. .||||... ||.......|  ||.|..   . .|         .|.. .. | |. ..|.|.| .  .. . .|.|...|     .|...|. ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

EIPF--QEFEARNWMEQILKAVAECHSAGILHRDLKPSNLLISSDGVL----KVADFG
. .|  .| |....| |||.... ||| ||.||||||.|.||...|..    |..|||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFG

Kinase IRAK-Un_ag.AA CDK 30-169 27 4.8e-39 122.46 In-house 1-160 (284) Show / Hide
Range on Protein: 30-169
Range on HMM: 1-160/284
Sequence Identity: 27% (47 aa)

YAVLDPIGSGAYSDVYHGKRRDDG-----LHVALKEV---------HDGKSSS---RELAALQLLTNSSHVVQLLDHVWLH-----------PGVLLVLE
|  |. || |.|  || .. ...|       ||||..         ..   ..   || . |. |    ..|.|.| .  .             . .| |
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL--HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFE

FLPGSLAEVIEERKEIPFQEFEARNWMEQILKAVAECHSAGILHRDLKPSNLLISSDGV-----LKVADFGTA
...  |.....            ...| |.|.... ||| .|.||||||.|.||...|.     ||.|||| |
YMDHDLKKYMD-----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLA

Kinase IRAK-Un_ag.AA CDK7 30-169 33 1.6e-32 83.57 In-house 1-149 (288) Show / Hide
Range on Protein: 30-169
Range on HMM: 1-149/288
Sequence Identity: 33% (51 aa)

YAVLDPIGSGAYSDVYHGKRRDDGLHVALKEVH---------DG--KSSSRELAALQLLTNSSH--VVQLLDHVWLHPGVLLVLEFLPGSLAEVIEERKE
|. .. || | .  || .     |  || |..          ||   .  ||   || .   .|  |. |.|       . ||..|..  | .||.  |.
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEM---QHDNVIGLIDIFMHKSNIQLVFDFMDWDLEVVIKD-KS

IPFQEFEARNWMEQILKAVAECHSAGILHRDLKPSNLLISSDGVLKVADFGTA
| .   .  ..| ..|. .  ||   |||||||| |||....|.||.|||| |
IILTPAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLA

Kinase IRAK-Un_ag.AA Pkinase 274-405 32 3.6e-32 114.81 Pfam 167-293 (293) Show / Hide
Range on Protein: 274-405
Range on HMM: 167-293/293
Sequence Identity: 32% (44 aa)

GEMTDCVGTRWYKAPELLYGSTSYNFAVDLWAVGCILGELIQGEPLFPGA----SDIDQLSRVVRVLGVPNETIWPGISSLPDYDKICFNDDRPPVTLAR
. ||. .||.|| |||.. |.. |  .|| |..|||| |.. |.|.|||.    . .||. ...|..| |..  ||  .| ...  . . . .    . .
S-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--F-HWT

ILPRASGEALRLIEKLLVYDPASRLSASQALSHEFF
  ...| |.. .|...| .||..|..| |.| |..|
F-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF

Kinase IRAK-Un_ag.AA CCRK 30-171 44 4.7e-30 100.87 In-house 1-148 (285) Show / Hide
Range on Protein: 30-171
Range on HMM: 1-148/285
Sequence Identity: 44% (66 aa)

YAVLDPIGSGAYSDVYHGKRRDDGLHVALKEV-----HDG--KSSSRELAALQLLTNSSHVVQLLDHVWLHPGVLLVLEFLPGSLAEVIEERKEIPFQEF
|..|| || ||   |.  |  . |  |||| |      ||      ||. ||| . ..  |||| |      |  || ||.   ||||. . .  |  | 
YCILDRIGEGAHGIVFKAKHVETGEIVALKKVALRRLDDGIPNQALREIKALQEIEDNQYVVQLKDVFPHGTGFVLVFEFMLSDLAEVVRHAQR-PLAEA

EARNWMEQILKAVAECHSAGILHRDLKPSNLLISSDGVLKVADFGTALV
  . .|  .|| || ||   |.|||||| |||||  | ||.|||| | |
QVKSYMQMLLKGVAHCHENNIMHRDLKPANLLISESGHLKIADFGLARV

Kinase IRAK-Un_ag.AA CDC2 30-167 32 5.1e-28 82.77 In-house 1-148 (301) Show / Hide
Range on Protein: 30-167
Range on HMM: 1-148/301
Sequence Identity: 32% (48 aa)

YAVLDPIGSGAYSDVYHGKRRDDGLHVALKEV-----HDG----KSSSRELAALQLLTNSSHVVQLLDHVWLHPGVLLVLEFLPGSLAEVIE--ERKEIP
|  .  || | |  || .| ....  |||| .      .|     .. ||.  |. | .   .|.| | .     . .| |.|   | .  .  . |. .
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKH

FQEFEARNWMEQILKAVAECHSAGILHRDLKPSNLLISSDGVLKVADFG
...   .. | |||..|. ||. .|.||||||.|.||...|..|.||||
MPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFG

Kinase IRAK-Un_ag.AA CDK5 30-169 34 1.2e-25 77.61 In-house 1-145 (287) Show / Hide
Range on Protein: 30-169
Range on HMM: 1-145/287
Sequence Identity: 34% (51 aa)

YAVLDPIGSGAYSDVYHGKRRDDGLHVALKEVH-DGK------SSSRELAALQLLTNSSHVVQLLDHVWLHPGVLLVLEFLPGSLAEVIEERKEIPFQEF
|  .. || | |  || .. .. .  ||||.|  |        .  || . |. |     .| | | .       || ||.   |   ......   .  
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKH-KNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNG-EMDMH

EARNWMEQILKAVAECHSAGILHRDLKPSNLLISSDGVLKVADFGTA
 ..  | | || .| ||.  .||||||| ||||.  | || |||| |
IIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLA

Kinase IRAK-Un_ag.AA CDK-Unclassified 92-169 33 1.6e-18 57.39 In-house 92-173 (324) Show / Hide
Range on Protein: 92-169
Range on HMM: 92-173/324
Sequence Identity: 33% (28 aa)

LHPGVLLVLEFLPGSLAEVIEERKEIPFQEFEARNWMEQILKAVAECHSAGILHRDLKPSNLLISSDG-----VLKVADFGTA
||| . .|.|  |  .  . .    ..    . || | |.|.  |  |...| |||.||.|..|.. .     .||.|||| |
LHPSFYMVMEYMPYTWYNQLHNNR-YNLSMCQIRNFMHQMLEGIAYLHCNKIMHRDIKPQNIMITNNNSTVSPMLKIADFGQA

Kinase IRAK-Un_ag.AA RCK 118-169 33 1.8e-17 51.74 In-house 99-161 (298) Show / Hide
Range on Protein: 118-169
Range on HMM: 99-161/298
Sequence Identity: 33% (21 aa)

PFQEFE--ARNWMEQILKAVAECHSAGILHRDLKPSNLLISS---------DGVLKVADFGTA
...|..   .| | |||.. | .|. |. |||||| |.....         ....|.|||| .
YLPENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLC

Kinase IRAK-Un_ag.AA PITSLRE 98-167 41 3.1e-16 55.76 In-house 80-151 (295) Show / Hide
Range on Protein: 98-167
Range on HMM: 80-151/295
Sequence Identity: 41% (30 aa)

LVLEFLPGSLAEVIEERK--EIPFQEFEARNWMEQILKAVAECHSAGILHRDLKPSNLLISSDGVLKVADFG
.|.|..   |. ..|  |  . ||.. |    | | |..|.  |.  |.||||| ||||.|  |.||..|||
MVMEYVEHDLKSLMENMKRRNQPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFG

Kinase IRAK-Un_ag.AA TyrKc 30-405 11 8.4e-10 -64.21 SMART 1-280 (280) Show / Hide
Range on Protein: 30-405
Range on HMM: 1-280/280
Sequence Identity: 11% (49 aa)

YAVLDPIGSGAYSDVYHGKRRDDGLHVALKEVHDGKSSS---RELAALQLL-TNSSHVVQLLDHVWLH-------PGVLLVLEFLP-GSLAEVIEERKEI
   .. .|.||.  ||.|. .   . || | .....      ||.  .  |  .  ..|.|.  .  .       . ...|.|. | |.| . . .... 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

PFQEFEARNWMEQILKAVAECHSAGILHRDLKPSNLLISSDGVLKVADFGTALVLPVE----------------NVE----------EALKSA-------
 ..  .  ... || .  .  || .. ||||   | |...... |..||| .  .  .                .            |...         
-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSD

-----------ATSSEQQPET-----MVPAQIRGS-KSYDRLEIEDSGTEVSPRVSDAEEEEDGARSRNDRYSDGEWEKTSNKDSDWYKSSKMWWCSSQV
            |  .| ..      | .....   |. .|... ...    | .|                                            
VWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY---P-MS--------------------------------------------

GNDDFRGEMTDCVGTRWYKAPELLYGSTSYNFAVDLWAVGCILGELIQGEPLFPGASDIDQLSRVVRVLGVPNETIWPGISSLPDYDKICFNDDRPPVTL
                                                                                                    
----------------------------------------------------------------------------------------------------

ARILPRASGEALRLIEKLLVYDPASRLSASQALSHEFF
    .... |  .....   .||..| . |.   ||.|
--F-VCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF

Kinase IRAK-Un_ag.AA RCK 30-59 30 1.4e-05 13.33 In-house 1-30 (298) Show / Hide
Range on Protein: 30-59
Range on HMM: 1-30/298
Sequence Identity: 30% (9 aa)

YAVLDPIGSGAYSDVYHGKRRDDGLHVALK
| ... .| |.|..|  ... ..|  || |
YQIIKQLGDGTYGCVMKAQNKETGEIVAIK

Kinase IRAK-Un_ag.AA MAPK 30-59 36 0.000559 9.39 In-house 1-36 (328) Show / Hide
Range on Protein: 30-59
Range on HMM: 1-36/328
Sequence Identity: 36% (13 aa)

YAVLDPIGSGAYSDVYHGKRRD------DGLHVALK
|  | |||.|||  |   . .       .| .||.|
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIK

Kinase IRAK-Un_ag.AA Pkinase_Tyr 30-87 21 0.002799 11.73 Pfam 1-70 (270) Show / Hide
Range on Protein: 30-87
Range on HMM: 1-70/270
Sequence Identity: 21% (15 aa)

YAVLDPIGSGAYSDVYHGKRR----DDGLHVALKEVHDGKSSS--------RELAALQLLTNSSHVVQLL
   .  .|.||. .||.|. .    .....|| | . .| ...        ||.. .  | .  ..|.|.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLY

Kinase IRAK-Un_ag.AA APH 32-141 16 0.003213 11.86 Pfam 1-113 (248) Show / Hide
Range on Protein: 32-141
Range on HMM: 1-113/248
Sequence Identity: 16% (21 aa)

VLDPIGSGAYSDVYHGKRRDDGLHVALKEVHDG---KSSSRELAALQLLTNS-S--HVVQLLD-------HVWLHPGVLLVLEFLPGSLAEVIEERKEIP
 . ||..|. ...|.    | .  . |.  ...    .  ||...|..| .     .| ..|.       | |    . ...|.|||  ..        .
WWRPISGGWSNRTYYRTTDD-RPRYVLRRYPPPWWAEELHREHRWLRHLAAHGIPVPVPRVLWGCTDDEFHGW----PWYLMEWLPGEDLWRW------H

-FQEFEARNWMEQILKAVAECHSA
  .. ..... |.. .. |. |..
ALHCAQRPALLEALARFLARLHQV

Kinase IRAK-Un_ag.AA PITSLRE 30-59 36 0.113669 2.12 In-house 1-30 (295) Show / Hide
Range on Protein: 30-59
Range on HMM: 1-30/295
Sequence Identity: 36% (11 aa)

YAVLDPIGSGAYSDVYHGKRRDDGLHVALK
.  |. |. |.|  || .| .  .  ||||
FQCLNRIHEGTYGVVYRAKDKRTDEIVALK

Kinase IRAK-Un_ag.AA Pkinase_Tyr 152-167 43 0.335541 4.69 Pfam 141-156 (270) Show / Hide
Range on Protein: 152-167
Range on HMM: 141-156/270
Sequence Identity: 43% (7 aa)

NLLISSDGVLKVADFG
| |.....| |..|||
NCLVTENNVVKICDFG

Kinase IRAK-Un_ag.AA APH 142-169 28 0.539839 4.27 Pfam 171-202 (248) Show / Hide
Range on Protein: 142-169
Range on HMM: 171-202/248
Sequence Identity: 28% (9 aa)

GILHRDLKPSNLLIS--SDGVLK--VADFGTA
...|.|..| |....  .||     | |...|
CWCHGDFHPGNVMWDPRPDGGRVTGVIDWDDA