Gene IRAK-Un_dk (S.moellendorffii)

IRAK-Un_dk

Species: S.moellendorffii
Alias: IRAK-Un_dk
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
IRAK-Un_dk.AA Protein None 1066 None Fasta, JSON
IRAK-Un_dk.NA RNA None 3201 None Fasta, JSON
IRAK-Un_dk.kin_dom Protein Kinase Domain None 206 None Fasta, JSON

Protein domain

Protein domains of IRAK-Un_dk.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LRRNT_2 IRAK-Un_dk.AA LRRNT_2 38-81 34 1.5e-07 27.41 Pfam 1-46 (46) Show / Hide 
Range on Protein: 38-81
Range on HMM: 1-46/46
Sequence Identity: 34% (17 aa)

VEEETWALLALKSAWN--DM-AEHLMSWDPSK--GTPCGAQGWVGIKCR
 .... ||||.||..|  |  .  | ||.||   ...|    |.|. | 
HNDDGQALLAFKSSLNDSDPHHGVLSSWNPSSSDSDCCS---WTGVTCD
LRR_1 IRAK-Un_dk.AA LRR_1 109-131 33 0.002156 16.2 Pfam 1-26 (26) Show / Hide 
Range on Protein: 109-131
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

QLTVLYLQQ-N--QLVGKIPAE-LCDL
.|..|.|.  |  .|.|.|| . .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-Un_dk.AA LRR_1 133-155 40 0.004237 15.16 Pfam 1-26 (26) Show / Hide 
Range on Protein: 133-155
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

ALEALYLHS-N--YLTGPIPPE-LGRL
 |. |.| . |   ||| |||. .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-Un_dk.AA LRR_1 157-179 40 0.024943 12.43 Pfam 1-26 (26) Show / Hide 
Range on Protein: 157-179
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

KLAVLLLFS-N--ELTGSIPET-LANL
.| .| | . |   |||.||.  . ||
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-Un_dk.AA LRR_1 181-203 40 0.002227 16.15 Pfam 1-26 (26) Show / Hide 
Range on Protein: 181-203
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

NLEALVLSE-N--SLSGSIPPA-IGSF
||. | ||  |  .|.|.|||  . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-Un_dk.AA LRR_1 205-227 40 0.009665 13.89 Pfam 1-26 (26) Show / Hide 
Range on Protein: 205-227
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

VLRVLYLDS-N--NLSGLIPPE-IGLL
 |..|.|.. |  ||.| |||. .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-Un_dk.AA LRR_1 233-249 47 3.188842 4.96 Pfam 7-26 (26) Show / Hide 
Range on Protein: 233-249
Range on HMM: 7-26/26
Sequence Identity: 47% (10 aa)

LFS-N--NLQGPIPPE-IGNL
| . |  ||.| |||. . ||
LSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-Un_dk.AA LRR_1 251-273 40 0.000381 18.87 Pfam 1-26 (26) Show / Hide 
Range on Protein: 251-273
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

SLEILELSS-N--QLSGGIPPE-LGNM
.|..| ||. |  .|.| |||. . |.
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-Un_dk.AA LRR_1 275-297 48 0.000436 18.66 Pfam 1-26 (26) Show / Hide 
Range on Protein: 275-297
Range on HMM: 1-26/26
Sequence Identity: 48% (13 aa)

SLVHLDLQF-N--NLSGPIPPD-ISLL
.| ||||.  |  ||.| |||. .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-Un_dk.AA LRR_1 299-321 33 0.013904 13.33 Pfam 1-26 (26) Show / Hide 
Range on Protein: 299-321
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

RLEVLSLGY-N--RLSGAIPYE-VGLL
.|..|.|.. |  .|.| || .    |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-Un_dk.AA LRR_1 323-345 33 0.005049 14.89 Pfam 1-26 (26) Show / Hide 
Range on Protein: 323-345
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

SLRLMYLPN-N--SLSGHIPAD-LEHL
.|.  .| . |  .|.|||| . . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-Un_dk.AA LRR_1 347-369 37 0.042208 11.62 Pfam 1-26 (26) Show / Hide 
Range on Protein: 347-369
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

MLTQVDLDF-N--ELTGSIPKQ-LGFL
 |.  ||.  |   |||.||.  .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-Un_dk.AA LRR_1 371-385 44 17.81297 2.31 Pfam 1-18 (26) Show / Hide 
Range on Protein: 371-385
Range on HMM: 1-18/26
Sequence Identity: 44% (8 aa)

NLQALFLQQ-N--KLQGK
||| | |.  |  .|.|.
NLQHLDLSGCNCCNLTGH
LRR_1 IRAK-Un_dk.AA LRR_1 397-414 45 0.161878 9.55 Pfam 6-26 (26) Show / Hide 
Range on Protein: 397-414
Range on HMM: 6-26/26
Sequence Identity: 45% (10 aa)

DLSG-N--YLSGPVPPE-LGNC
|||| |   |.| .||. . |.
DLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-Un_dk.AA LRR_1 416-438 33 0.008324 14.12 Pfam 1-26 (26) Show / Hide 
Range on Protein: 416-438
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

LLTVLNLAD-N--LLTGTVPEE-LGSL
 |..|.| . |   |||..|.. . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-Un_dk.AA LRR_1 440-462 33 0.018028 12.93 Pfam 1-26 (26) Show / Hide 
Range on Protein: 440-462
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

FLASLVLEN-N--QLEGKVPSS-LGNC
 | .| | . |  .|.|..|.| . |.
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-Un_dk.AA LRR_1 464-486 40 0.014363 13.28 Pfam 1-26 (26) Show / Hide 
Range on Protein: 464-486
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

GLIAIRLGH-N--RLTGTIPES-FGLL
 |  . |.. |  .|||.||.| |  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-Un_dk.AA LRR_1 488-510 40 0.003625 15.4 Pfam 1-26 (26) Show / Hide 
Range on Protein: 488-510
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

HLQTFDMSF-N--GLTGKIPPQ-IGLC
.||. |.|  |   |||.|||  .  .
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-Un_dk.AA LRR_1 512-534 33 2.728695 5.2 Pfam 1-26 (26) Show / Hide 
Range on Protein: 512-534
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

SLLSLALND-N--ALKGSIPTE-LTTL
.| .| |.. |   | |.|| . .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-Un_dk.AA LRR_1 536-558 37 1.143058 6.54 Pfam 1-26 (26) Show / Hide 
Range on Protein: 536-558
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

ILQFASMAH-N--KLTGVIPPT-LDSL
 ||  .. . |  .||| |||  . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-Un_dk.AA LRR_1 560-582 37 0.012695 13.47 Pfam 1-26 (26) Show / Hide 
Range on Protein: 560-582
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

QLQVLNLEG-N--MLSGSIPAK-VGAI
.||.|.| | |   |.|.||     . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-Un_dk.AA LRR_1 584-606 35 0.007851 14.21 Pfam 1-26 (26) Show / Hide 
Range on Protein: 584-606
Range on HMM: 1-26/26
Sequence Identity: 35% (10 aa)

DLRELVLSS-N--RLS-NNIPSS-LGSL
 |..| ||. |  .|. . ||.| . .|
NLQHLDLSGCNCCNLTGH-IPPSCF-NL
LRR_1 IRAK-Un_dk.AA LRR_1 608-630 40 0.009176 13.97 Pfam 1-26 (26) Show / Hide 
Range on Protein: 608-630
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

FLTVLLLDK-N--NFTGTIPPT-LCNC
 |..| |.  |  |.||.|||  . |.
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-Un_dk.AA LRR_1 632-653 33 0.003625 15.4 Pfam 1-26 (26) Show / Hide 
Range on Protein: 632-653
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

SLMRLNLSS-N--GLVGEIPR--LGSF
.| .|.||. |   |.|.||   . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
Kinase IRAK-Un_dk.AA TKL 754-1025 23 1.9e-61 210.48 In-house 1-364 (364) Show / Hide 
Range on Protein: 754-1025
Range on HMM: 1-364/364
Sequence Identity: 23% (91 aa)

LGKGGFGAVYDAVLPD---------GSHLAVKRLRNENVANDPS---------------------------FEAEISTLGLIKHRNLVSLKGFYCSAQE-
.|.|||| || ...           |   |||... .|. .. .                           .| ||  .  ..| |.|...|. |. .  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------KLLFYDYMPCGSLHDVLHGGGVASASPSTLLSWMARLRIAVGTARGLLYLHE------GCSPRIIHRDVKSSNILLDSDME-------
              . ..|.|.|||...||              |  |.|.| ..|||. |||       .  | ||||| ||.|||.|....       
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------------WHQRCRWALDIARGMNYLHSMNPKWCT-KPPIIHRDLKSKNILVDENWTNVSNYMY

-------PHIADFGLARLV----ENNATHLTTG--------------IAGTLGYIAPEVVS----------------TCRLSEKTDVYSFGIVLLELLTG
       . |.||||.| .    ..|.|  |..              . ||... ||||                      |||.||||||||| |.||.
NPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTR

RKPLV-LGNLGEIVSVTTWVKAMNQQGK--GMETFDS------ELASSSPSSGPVLVQMMQLALHCTSDWPSRRPSMSKVVAFL
..|   ...  .|..    ...|  .    |.           .     .   ... .| .|. .| .  |. |||.....  |
CRPYYDYPYMPMIFQD-P-FEEMFMMVCDKGLRPPIPPIWQNHH-K-M-CPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAK-Un_dk.AA IRAK 748-953 36 6.2e-60 205.43 In-house 1-223 (317) Show / Hide 
Range on Protein: 748-953
Range on HMM: 1-223/317
Sequence Identity: 36% (84 aa)

FDDSHLLGKGGFGAVYDAVLPDGSH--LAVKRLRNENVAN----DPSFEA---EISTLGLIKHRNLVSLKGFYCSAQEKL-LFYDYMPCGSLHDVLHGGG
|. ....|.|||| || ... ..     |||.|....  .    . .| .   |. .. .. | |.|.| | ||.. ... | |.||| |||.| |.. .
FHKDNRIGEGGFGCVYRGQW-KNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYG-YCTERQCHCLVYPYMPNGSLEDRLWCQD

VASASPSTL--LSWMARLRIAVGTARGLLYLHEGCSPR--IIHRDVKSSNILLDSDMEPHIADFGLARLV----ENNATHL----TTGIAGTLGYIAPEV
 .     ..  |||  |. |. |||.|. .||.  .|   |||.|.||.||||| ...| |.||||.|      .. .. .    |  . ||. | .|| 
GQ----CPPKPLSWHQRCSICWGTACGIQFLHQ-NHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEF

VS--TCRLSEKTDVYSFGIVLLELLTGRKP
    . .|. |||||||||||||.|||...
IRDPQGQLTKKTDVYSFGIVLLEVLTGCRA
Kinase IRAK-Un_dk.AA Pkinase 748-951 26 9.5e-49 173.06 Pfam 1-209 (293) Show / Hide 
Range on Protein: 748-951
Range on HMM: 1-209/293
Sequence Identity: 26% (58 aa)

FDDSHLLGKGGFGAVYDAVLPDGSH-LAVKRLRNENVANDPSFEA-----EISTLGLIKHRNLVSLKGFYCSAQEKLLFYDYMPCG----SLHDVLHGGG
.     .|.|.|| || ..  . ..  |||... .  ...   ..     ||. .  ..| | | |.... . ..  .  .|...|    .|.|....  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--

VASASPSTLL--SWMARLRIAVGTARGLLYLHEGCSPRIIHRDVKSSNILLDSDMEP----HIADFGLARLVENNATHLTTGIAGTLGYIAPEVVS-TCR
    . .. .  |.    ...  ..||| |.|. .  .|||||.|..|||.|.....    .|.|||||.....   . .|...||..|.||||.     
----WRHGCFYFSEWECKFYMYQILRGLEYCHS-M--GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQY

LSEKTDVYSFGIVLLELLTGR
 . | |..|.|..| |.|.||
YGPKVDMWSCGCILYEMLCGR
Kinase IRAK-Un_dk.AA MLK 748-953 28 7.1e-40 136.03 In-house 1-235 (291) Show / Hide 
Range on Protein: 748-953
Range on HMM: 1-235/291
Sequence Identity: 28% (69 aa)

FDDSHLLGKGGFGAVYDAVLPDGSH-----LAVKRLR---NENVAN----DPSFEAEISTLGLIKHRN----LVSLKGFYCSA-QEKLLFYDYMPCGSLH
.. .. .|.|.||.|. ..   .       .|||| |      ..     .  || |.  |  ..|.|     . ..|   .  .. ..   |...|||.
IQFHEWIGSGSFGKVWKGRW-RNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLY

DVLHGGGVASA------------SPSTLLSWMARLRIAVGTARGLLYLHEGCSPRIIHRDVKSSNILLDS------DMEPHIADFGLARLVENN-ATHLT
.||||.   ..            ... ...|      |.  |||. |||.   . ||||| ||.|||.|       ..   |.|||..| . .. ...  
NVLHGARSKWMDANHNQKNDRVYDHDHAMNW------ALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNM--

TGIAGTLGYIAPEVV---STCRLSEKTDVYSFGIVLLELLTGRKP
.. |||. . ||||       . ||| ||.|.|.|| |.||.. |
MSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVP
Kinase IRAK-Un_dk.AA TKL-Unique 750-950 32 3.2e-39 136.01 In-house 1-224 (290) Show / Hide 
Range on Protein: 750-950
Range on HMM: 1-224/290
Sequence Identity: 32% (73 aa)

DSHLLGKGGFGAVYDAVLPDGSHLAVKRLR-NENVAND--PSFEAEISTLGLIK-HRNLVSLKGFYC----SAQEKLLFYDYMPCGSLHDVLHGGGVAS-
.. ..| ||.|.|| .. . |.  |.|..  || . |.    || |....  .. | |.| . |.      .. .  .. .|.| |||.||||     . 
FWNKIGEGGYGQVYKGKWR-GYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

-ASPSTLLSWMARLRIAVGTARGLLYLHEGCSPRIIHRDVKSSNILLDSD-----MEPHIADFGLARLVENNATHLTTGI--------AGTLGYIAPEVV
  .... |..  |...|   |.|. |||    | ||||| ||||.|.|..     .   |.||||...  .. .  ....         |.. ..|||| 
NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVL

ST--CRLSEKTDVYSFGIVLLELLTG
.   |  ||| ||||||||| |..|.
RMNFCQYSEKSDVYSFGIVLWEIATR
Kinase IRAK-Un_dk.AA S_TKc 748-1025 22 2.2e-37 131.46 SMART 1-231 (231) Show / Hide 
Range on Protein: 748-1025
Range on HMM: 1-231/231
Sequence Identity: 22% (66 aa)

FDDSHLLGKGGFGAVYDAVLPD-GSHLAVKRLRNENVANDPSFEAEISTLGLIKHRNLVSLKGFYCSAQEKLLFYDYMPC--GSLHDVLHGGGVAS----
..   ..|||.|| || ..  . | . |.|...        ... ||. |   .| |.| |.... . ..  .. .|..   |.|.|...  |       
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

ASPSTLLSWMARLRIAVGTARGLLYLHEGCSPRIIHRDVKSSNILLDSDMEPHIADFGLARLVENNATHLTTGIAGTLGYIAPEVVSTCRLSE-KTDVYS
 .. .  ..|. .      ...| |.|   | .|||||.| .|||||.  .  |.||||||..        | . ||. |.||||.     .  | |..|
FPE-HARFYMYQI------CCALEYCH---SHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWS

FGIVLLELLTGRKPLVLGNLGEIVSVTTWVKAMNQQGKGMETFDSELASSSPSSGPVLVQMMQLALHCTSDWPSRRPSMSKVVA---------FL
.|..| |.|.|. |    .. ..  .                                 .. ..  .|    |..||.  .. .         ..
CGCILYEMLCGYPPFP--QMQMMFKKIG-----------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAK-Un_dk.AA Dicty4 748-953 34 6.9e-36 117.28 In-house 1-216 (277) Show / Hide 
Range on Protein: 748-953
Range on HMM: 1-216/277
Sequence Identity: 34% (77 aa)

FDDSHLLGKGGFGAVYDAVLPDGSHLAVKRL--RNENVAND--PSFEAEISTLGLIKHRNLVSLKGFYCS----AQEKLL-FYDYMPCGSLHDVLHGGGV
 .   ..|||.|| || .    |.  ||| |  .|.|.  .   .| .|.. .. | | |.. ..| .|     . .|..    ||| |.|. .||    
INIEQRIGKGSFGEVYKGTWR-GKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMG-ACTAPRSHPGKMCIVTEYMPKGNLYSLLH----

ASAS------PSTLLSWMARLR---IAVGTARGLLYLHEGCSPRIIHRDVKSSNILLDSDMEPHIADFGLARLVENNATHLT--TGIAGTLGYIAPEVVS
   .      .|. |.|  ..|   .|  .|||. .||. | |.||||| ||.|.| | ..   ..||||...     .| .  .. .|| .. ||||  
---DKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHC-CNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMM

TCRLSEKTDVYSFGIVLLELLTGRKP
  .  || ||||||||| |.||.  |
HQPYNEKADVYSFGIVLWEILTRQEP
Kinase IRAK-Un_dk.AA TK 748-1025 14 1.2e-34 112.96 In-house 1-486 (486) Show / Hide 
Range on Protein: 748-1025
Range on HMM: 1-486/486
Sequence Identity: 14% (70 aa)

FDDSHLLGKGGFG---AVYDAVLPDGS--------------------------HLAVKRLRNENVANDPSFEA--------------EISTLGLIK----
    . ||.| ||    || . . ...                            ||| |. .. ...  |..              | . . . .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HRNLVSLKG-------------FYCSAQEKLLFYDYMPCGS----LHDVLH--GGGVASASPSTL----------------------------------
 | |.|.| |             . .  .  ..   |||.|.    |.| |.   ..    ...                                    
HHPNIVRLYGVCTQGEPKPCFEVV-VHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQD

--------------------------------LSWMARLRIAVGTARGLLYLHEG----CSPRIIHRDVKSSNILLDSDME-----------PHIADFG-
                                |.   .| ...  |.|. |||.       ....|||.   |.|.....              ||||| 
YDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGL

-------LARLVENNATHLTTGIAGTLG-------------------------YIAPEVVS---------TCRLSEKTDVYSFGIVLLELLT-GRKPLV-
       ||| ....    ...  || .                         . |||..          . . ..|.||.|||... |..| |..|   
SRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYG

-LGNLGEIV-----SVTTWVKAMN--------QQGKGMETFDSELAS------SSPSSGPVLVQMMQL-ALHCTSDWPSRRPSMSKVVAFL
 . | . ..      |   ...          ..| .|.    ....        .   ..  .....  . | .  |..||..| .. .|
GMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRM-H-PPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase IRAK-Un_dk.AA STE 748-951 21 7e-34 117.06 In-house 1-265 (359) Show / Hide 
Range on Protein: 748-951
Range on HMM: 1-265/359
Sequence Identity: 21% (60 aa)

FDDSHLLGKGGFGAVYDAVLPDGS--H--------------LAVKRLRNENV-----------------ANDPSFEAEISTLGLIK--HRNLVSLKGFYC
...   .|||.|| || |.  . .  |               |.|... ||                   .  ... ||...   .  | | |   | | 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

SA-------QEKLLFYDYMPCGSLHDVLHGGGVASASPS------TLLSWMARLRIAVGTARG-LLYLHEGCSPRIIHRDVKSSNILLDSDMEPHIADFG
         .|  ..  ||. ||| |...  .    . .      . ..     .|.. . .| | |||.     |||||.|..||||       ..|||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDFG

LARLVENNATHL----------TTG-----IAGTLGYIAPEVVS--TCR----LSEKTDVYSFGIVLLELLTGR
..  .... ...          |..     ..||  . ||||..  ..      ..| |..|.|....|..||.
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK
Kinase IRAK-Un_dk.AA LRRK 822-953 36 6.2e-32 110.24 In-house 135-282 (351) Show / Hide 
Range on Protein: 822-953
Range on HMM: 135-282/351
Sequence Identity: 36% (56 aa)

DYMPCGSLHDVLH---GGG---VASASPSTLLSWMARLRIAVGTARGLLYLHEGCSPRIIHRDVKSSNILLDSDMEP------------HIADFGLARLV
.|.|.|.|...||     |   .      . .||| .|.||.  |.|. |||  ..| ||||| || |||| | ...            .|||||. |. 
EYAPHGDLYHFLHNKKQDGFHFMK-----AHISWMLKLKIALQIAKGMEYLH-SHNPPIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMF

ENNATH-LTTGIAGTLGYIAPEVVS---TCRLSEKTDVYSFGIVLLELLTGR-KP
    .. .. |  |. |. |||..    .   .||.|.||||..| ||||..  |
-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHP
Kinase IRAK-Un_dk.AA Dicty4-Unclassified 789-953 35 7e-32 106.45 In-house 45-207 (263) Show / Hide 
Range on Protein: 789-953
Range on HMM: 45-207/263
Sequence Identity: 35% (60 aa)

FEAEISTLGLIKHRNLVSLKGFYCSAQ-----EKLLFYDYMPCGSLHDVLHGGGVASASPSTLLSWMARLRIAVGTARGLLYLHEGCSPRIIHRDVKSSN
| .|.  ||.| | ||| ..| || .              |. | |  | |        |  | . .  ...|   |.|. .||   .  .||||.||||
FKKEVEILGSIQHPNLVKCYG-YCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQPIKLDDTLI-IKYAFDIAQGMQHLH---TRNFIHRDIKSSN

ILLDSDMEPHIADFGLARLVENNATHLTTGIAGTLGYIAPEVVSTCRLSEKTDVYSFGIVLLELLTGRKP
||.| .    |||||..| ...| .   | ||||    .||.        | ||||....| ||.||  |
ILMDKHFNIKIADFGISRVIDFNFN--MTTIAGTPKWESPECLMHESYNQKSDVYSYAMMLYELATGDEP
Kinase IRAK-Un_dk.AA DRK 755-949 34 1.8e-29 97.03 In-house 8-197 (258) Show / Hide 
Range on Protein: 755-949
Range on HMM: 8-197/258
Sequence Identity: 34% (70 aa)

GKGGFGAVYDAVLPDGSHLAVKRLRNENVA-----NDPSFEAEISTLGLIKHRNLVSLKGFYCSAQEKLLFYDYMPCGSLHDVLHGGGVASASPSTLLSW
|.|..| |.      |.  |||.| | |.      |.  |  ||  .    | | .   |      . .    ||| |||  .||        .|  ..|
GRGNYGEVFRGTW-RGTQVAVKMLFNHNINDENFLNE--FHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILH-------DESIEMDW

MARLRIAVGTARGLLYLHEGCSPRIIHRDVKSSNILLDSDMEPHIADFGLAR---LVENNATHLTTGIAGTLGYIAPEVVSTCRLSEKTDVYSFGIVLLE
  .....   |.|. ||| .| | ||||| || | | |      .|||||.     ..   .  |    || . .||||    |  || |||||.||| |
PLMKQMMFDCAKGMIYLH-CCNPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQHKFAMT--MCGTPCWTAPEVLRNQRYTEKADVYSFAIVLWE

LLT
..|
CVT
Kinase IRAK-Un_dk.AA Pkinase_Tyr 748-953 27 4.4e-27 92.36 Pfam 1-214 (270) Show / Hide 
Range on Protein: 748-953
Range on HMM: 1-214/270
Sequence Identity: 27% (61 aa)

FDDSHLLGKGGFGAVYDAVLP-----DGSHLAVKRLRNENVAND---PSFEAEISTLGLI-KHRNLVSLKGFYCSAQEK---LLFYDYMPCGSLHDVLHG
    . ||.| || || ...      .. . ||| |..     .    .| .|....  . .| |.|.| |   . .|    ..   |||.|.|.| |. 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

GGVASASPSTLLSWMARLRIAVGTARGLLYLHEGCSPRIIHRDVKSSNILLDSDMEPHIADFGLARLVENNATH-LTTG-----IAGTLGYIAPEVVSTC
      ..   |.    | ...  |.|. ||..     .||||.   |.|.....   |.||||||...|  .   ..|     |  .    |||. ...
HR----EDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWM----APECINYG

RLSEKTDVYSFGIVLLELLT-GRKP
. ..|.||.|||... |..| |..|
KFTTKSDVWSFGVLMWEIFTYGEQP
Kinase IRAK-Un_dk.AA TyrKc 748-1025 22 1.3e-17 62.08 SMART 1-280 (280) Show / Hide 
Range on Protein: 748-1025
Range on HMM: 1-280/280
Sequence Identity: 22% (70 aa)

FDDSHLLGKGGFGAVYDAVLPDGSHLAVKRLRNENVANDPSFEAEISTLGLI--KHRNLVSLKGFYCSA-------QEKLLFYDYMPCGSLHDVLHGGGV
    . || | || || ...      ||| |...       |  |.. .  .  .| |.| | |   .        .  ..   ||| |.|.| |.  . 
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

ASASPSTLLSWMARLRIAVGTARGLLYLHEGCSPRIIHRDVKSSNILLDSDMEPHIADFGLARLVENN-------ATHLT----TGIA-GTLGYIAPEVV
        |..   | ...  |.|  |||.    ..||||    |.|....    |.||||.| ...         .  .     | .   .   |||. 
K-------LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

STCRLSEKTDVYSFGIVLLELLTGRKPLVLG---NLGEIVSVTTWVKAMNQQGKGMETFDSELASSSPSSGP-----VLVQMMQLALHCTSDWPSRRPSM
 ... ..|.||.|||... |..|  ..   |   .    .| .  | .  .||. |.  .. .        |         | |. . |    |. ||..
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ---MMSNQE-VIEYVKQGYRMPQPPNDY--------PMSFVCCPDEMYQIMKQCWHEDPEDRPTF

SKVVAFL
| .. ..
SEIHECF
Kinase IRAK-Un_dk.AA LRRK 748-786 21 0.000957 9.11 In-house 1-57 (351) Show / Hide 
Range on Protein: 748-786
Range on HMM: 1-57/351
Sequence Identity: 21% (12 aa)

FDDSHLLGKGGFG-AVYDAVLPD----GSHLAVKRLRN-------------ENVAND
.    ..|.||||  || | . .       .. |.| .             ..||..
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIK
Kinase IRAK-Un_dk.AA LRRK 1006-1027 36 0.001061 8.95 In-house 330-351 (351) Show / Hide 
Range on Protein: 1006-1027
Range on HMM: 330-351/351
Sequence Identity: 36% (8 aa)

HCTSDWPSRRPSMSKVVAFLEL
|| .  | .||..|..| .|. 
HCWQHDPKKRPHFSQIVKRLSQ
Kinase IRAK-Un_dk.AA DRK 1002-1027 38 0.003974 6.48 In-house 233-258 (258) Show / Hide 
Range on Protein: 1002-1027
Range on HMM: 233-258/258
Sequence Identity: 38% (10 aa)

QLALHCTSDWPSRRPSMSKVVAFLEL
||   | .  |. ||||  ..  || 
QLMNDCWNEDPQHRPSMQECLERLEA
Kinase IRAK-Un_dk.AA IRAK 1000-1025 34 0.014028 5.16 In-house 292-317 (317) Show / Hide 
Range on Protein: 1000-1025
Range on HMM: 292-317/317
Sequence Identity: 34% (9 aa)

MMQLALHCTSDWPSRRPSMSKVVAFL
| |.|. |.     ||..| .|.. |
MCQCACCCGHHRANRRCDMAWVMQQL
Kinase IRAK-Un_dk.AA MLK 1012-1025 42 0.014916 4.83 In-house 278-291 (291) Show / Hide 
Range on Protein: 1012-1025
Range on HMM: 278-291/291
Sequence Identity: 42% (6 aa)

PSRRPSMSKVVAFL
|..|||.. .| .|
PHKRPSFRQIVQHL
Kinase IRAK-Un_dk.AA Dicty4-Unclassified 1007-1025 31 0.022471 3.9 In-house 245-263 (263) Show / Hide 
Range on Protein: 1007-1025
Range on HMM: 245-263/263
Sequence Identity: 31% (6 aa)

CTSDWPSRRPSMSKVVAFL
| .. | .||.| ...  |
CWHNDPNKRPTMNQIIQYL
Kinase IRAK-Un_dk.AA Dicty4 1012-1027 33 0.08174 2.03 In-house 260-277 (277) Show / Hide 
Range on Protein: 1012-1027
Range on HMM: 260-277/277
Sequence Identity: 33% (6 aa)

PSRRPSMSKVVAF--LEL
|..|||.. ..    || 
PQHRPSFEEIIQRRILEH
Kinase IRAK-Un_dk.AA Pkinase_Tyr 1012-1025 35 0.543727 3.98 Pfam 257-270 (270) Show / Hide 
Range on Protein: 1012-1025
Range on HMM: 257-270/270
Sequence Identity: 35% (5 aa)

PSRRPSMSKVVAFL
|..||..| .. .|
PEDRPTFSEIHEQL