Gene IRAK-Un_bv (S.moellendorffii)

IRAK-Un_bv

Species: S.moellendorffii
Alias: IRAK-Un_bv
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
IRAK-Un_bv.AA Protein None 312 None Fasta, JSON
IRAK-Un_bv.NA RNA None 939 None Fasta, JSON
IRAK-Un_bv.kin_dom Protein Kinase Domain None 202 None Fasta, JSON

Protein domain

Protein domains of IRAK-Un_bv.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IRAK-Un_bv.AA TKL 80-276 22 4e-47 162.87 In-house 1-287 (364) Show / Hide 
Range on Protein: 80-276
Range on HMM: 1-287/364
Sequence Identity: 22% (66 aa)

LGTGGFGKVYRGILPGEN--------SPVAIKKMVR---------------------------DSHQGEREFLAELQIISKRSHRNLVPLRGWHCARDHR
.| ||||.||.|.. |..         .||.||. .                           .... . ..  |. ..|...| |.|.. |  |. ...
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

E-----------LVLVYDYMPQGSVESALFHKGDALLLLWDARLRILSGLAAALIYLHEDW-----EQQVIHRDVKCSNVMLDEEFR-------------
.           | .|..|.| || .. |          |. |.|.  . | .. ||| ..       ..|||| | .|...|| ..             
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW

-ARLGDFGLARTASHDVS------------------SRTTTLAGTLGYIAPEV--GVTY--------------KFTPASDVYSYGVVTLEVVTGRR
 . ..||||.|. |.. .                  ..| |  ||... ||||  | ..              ......||||.|.|  |..|..|
CCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR
Kinase IRAK-Un_bv.AA IRAK 76-277 34 6.5e-47 162.18 In-house 3-223 (317) Show / Hide 
Range on Protein: 76-277
Range on HMM: 3-223/317
Sequence Identity: 34% (78 aa)

EHNLLGTGGFGKVYRGILPGENSPVAIK--KMVRDSHQGE--REFLA---ELQIISKRSHRNLVPLRGWHCARDHRELVLVYDYMPQGSVESALF-HKGD
. |..| |||| |||| . ..  ..|.|  | ..|. ..|  ..|..   ||.. ..  | |.||| |   .|.  .. |||.||| || |  |  ..|.
KDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQ--CHCLVYPYMPNGSLEDRLWCQDGQ

ALL--LLWDARLRILSGLAAALIYLHEDW-EQQVIHRDVKCSNVMLDEEFRARLGDFGLART---AS--HDVSS---RTTTLAGTLGYIAPEVGV--TYK
  .  | |  |. |..|.| .. .||..     .||.|.| .|. ||. | . ..||||.|    ||   . ..   .| .. ||. | .||     . .
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQ

FTPASDVYSYGVVTLEVVTGRRV
 |. .|||| |.| |||.||.|.
LTKKTDVYSFGIVLLEVLTGCRA
Kinase IRAK-Un_bv.AA Pkinase 80-275 26 9.1e-42 148.77 Pfam 7-209 (293) Show / Hide 
Range on Protein: 80-275
Range on HMM: 7-209/293
Sequence Identity: 26% (55 aa)

LGTGGFGKVYRGILPGENSPVAIKKMVRDSHQGEREF-----LAELQIISKRSHRNLVPLRGWHCARDHRELVLVYDYMPQG----SVESALF-HKGDAL
.| |.||.||...  |..  ||.|.. .. |. . .      |.|.||  . .| | | |..|     .... .| .|.. |    .  . .  ... ..
IGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCF

LLLWDARLRILSGLAAALIYLHEDWEQQVIHRDVKCSNVMLDEEFRA----RLGDFGLARTASHDVSSRTTTLAGTLGYIAPEVGV-TYKFTPASDVYSY
.. ..   ...  .. .| |.|.     .||||.| .|...|..       ...|||||. ...  .| .||..||..|.||||     . .|..|..|.
YFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVVTLEVVTGR
|..  |...||
GCILYEMLCGR
Kinase IRAK-Un_bv.AA TK 80-273 16 2.3e-28 91.55 In-house 7-389 (486) Show / Hide 
Range on Protein: 80-273
Range on HMM: 7-389/486
Sequence Identity: 16% (63 aa)

LGTGGFG---KVYRGILPGEN-------------------------SPVAIKKMVRDSHQGEREFLA--------------ELQIISKRS-----HRNLV
|| | ||   .||.|.. |.|                          |||.| .  .... ..||..              |...... .     | |.|
LGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIV

PLRG-WHCARD---------HRELVLVYDYMPQGS----VESALF-HKGDALL-----------------------------------------------
 | |  .  .           . . .|  ||| |.      . |  .....                                                 
RLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIK

-------------------------LLWDARLRILSGLAAALIYLHED---WEQQVIHRDVKCSNVMLDEEFR-----------ARLGDFG--------L
                         |    .| .   .|... |||.     .|...|||. . |....|. .           ....|||        |
DHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVL

ARTASHDVSSRTTTLAGTLG-------------------------YIAPEVGV---------TYKFTPASDVYSYGVVTLEVVT
||   .|   ....  || .                         . |||.           . |||..|||.|.||.  |..|
ARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFT
Kinase IRAK-Un_bv.AA RIPK 80-277 27 5.4e-27 89.02 In-house 1-227 (290) Show / Hide 
Range on Protein: 80-277
Range on HMM: 1-227/290
Sequence Identity: 27% (63 aa)

LGTGGFGKVYRGILPGENSPVAIKK---MVRDSH---QGEREFLAELQIISKRSHRNLVPLRGWHCARDH---RE-LVLVYDYMPQGSVESALFHKG--D
.| ||||.|..      .  ||.|      .. |   | . . . | ..  |  ... ||. |     .     . . .|  ||. || .  |  |    
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ

ALLLLWDARLRILSGLAAALIYLHEDWEQQ--VIHRDVKCSNVMLDEEFRARLGDFGLA--RTAS--HD-------VSSRTTTLA-GTLGYIAPEVGV--
   ..|. | |..   . .  |||    ..  .|||| | .|. .| .| . . |||||  .. |  |.       |.| .  .  ||| |..||  .  
HHPDPWPLRCRMIHEISCGMCYLH---SMNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTD

TYKF----TPASDVYSYGVVTLEVVTGRRV
  |     ||..||||...|. || |.. .
NKKPIKVVTPKYDVYSFAIVMWEVLTQKHP
Kinase IRAK-Un_bv.AA STE 75-275 21 2.9e-26 89.8 In-house 1-265 (359) Show / Hide 
Range on Protein: 75-275
Range on HMM: 1-265/359
Sequence Identity: 21% (60 aa)

PEH-NLLGTGGFGKVYRG-------ILPGENSP---------VAIKKMVRDS-----------------HQGEREFLAELQIISKRS--HRNLVPLRGWH
 |.   .| |.||.||..       |    .           .|||.|  ..                 |. . ..| |..| .| .  | | |   | .
WEGIEKIGKGAFGTVYKAMNHKNCNIH-KTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

CARDHR-----ELVLVYDYMPQGSVESALFHKGDALLLLW----------DARL-RILSGLAAA-LIYLHEDWEQQVIHRDVKCSNVMLDEEFRARLGDF
   .|      || ..  ||. ||... . ||.  .  |              . .|.  .  . | |||   ....||||.|..|..|     . | ||
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLH---SHHIIHRDIKPANILL-----VKLCDF

GLARTASH---------------DVSSRTTTLAGTLGYIAPEVGVTYK------FTPASDVYSYGVVTLEVVTGR
|..   ..               . .....|..||  . ||||    .       .  .|..| | . .| .||.
GVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK
Kinase IRAK-Un_bv.AA S_TKc 77-312 24 5.7e-26 93.51 SMART 4-231 (231) Show / Hide 
Range on Protein: 77-312
Range on HMM: 4-231/231
Sequence Identity: 24% (63 aa)

HNLLGTGGFGKVYRGILPGENSPVAIKKMVRDSHQGEREFLAELQIISKRSHRNLVPLRGWHCARDHRELVLVYDYMPQ--GSVESALFHKGDAL----L
....| |.|||||...  . .  ||||..        . .. |.|| .|  | |.| | ..       .| .| .|...  |.. . . ..|       .
LRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

LLWDARLRILSGLAAALIYLHEDWEQQVIHRDVKCSNVMLDEEFRARLGDFGLARTASHDVSSRTTTLAGTLGYIAPEVGVTYKFTP-ASDVYSYGVVTL
   .|| ...  .. || |.|   ....||||.| .|..|||  .  ..||||||          ||. ||. |.||||    .... ..|..| |..  
PE-HAR-FYMYQICCALEYCH---SHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

EVVTGRRVIGSSKEKDHNAWLLVPWVEEQYAAGKLLGVV------------------DPRL
| ..|.       . .    ...   |      |.| .                   .| .
EMLCGYPPFP---QMQMMFKKIG-SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase IRAK-Un_bv.AA TKL-Unique 78-274 29 5.9e-26 88.61 In-house 3-224 (290) Show / Hide 
Range on Protein: 78-274
Range on HMM: 3-224/290
Sequence Identity: 29% (66 aa)

NLLGTGGFGKVYRGILPGENSPVAIKKMVR--DSH-QGEREFLAELQIISKRS-HRNLVPLRGWHCAR---DHRELVLVYDYMPQGSVESALFHK-----
|..|.||.|.||.|. .|.  |||||.     ||. . ..||  |. ...|   | |.| . |. |.    .  .. .| .|.| ||  . | |      
NKIGEGGYGQVYKGKWRGY--PVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGY-CMDHQVYPPNMCIVMEYCPGGSLYDVL-HQNNNNN

---GDALLLLWDARLRILSGLAAALIYLHEDWEQQVIHRDVKCSNVMLDEE-----FRARLGDFGLARTASHDVSSRTT--------TLAGTLGYIAPEV
    . . | .  |...    | ...|||      .|||| | ||. .|..     ..... ||||....| .  . ..        |  |.. ..||||
NNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEV

GVT--YKFTPASDVYSYGVVTLEVVTG
     ....  |||||.|.|  | .|.
LRMNFCQYSEKSDVYSFGIVLWEIATR
Kinase IRAK-Un_bv.AA Pkinase_Tyr 80-273 28 1.4e-25 87.3 Pfam 7-209 (270) Show / Hide 
Range on Protein: 80-273
Range on HMM: 7-209/270
Sequence Identity: 28% (60 aa)

LGTGGFGKVYRGILP----GENSPVAIKKMVRDSHQGE----REFLAELQIISKR-SHRNLVPLRGWHCARDHRE--LVLVYDYMPQGSVESALFHK---
|| | ||.||.|..     ... |||.|.. ....  |    ..|..|..| ..  .| |.| | |  | .. .   . .|  ||| |.  . |  .   
LGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGV-CTDQGEPNQIYIVMEYMPHGDLLDYLRKHRED

GDALLLLWDARLRILSGLAAALIYLHEDWEQQVIHRDVKCSNVMLDEEFRARLGDFGLARTA-SHDVS-SRTTTLAGTLGYIAPEVGVTYKFTPASDVYS
...| . .   | .    |... ||.   ... ||||. . |....|.. .. .||||||.  . |     ..         |||.  ..||| .|||.|
KQPLTMKD--LLQMCWQIAKGMEYLE---SKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWS

YGVVTLEVVT
.||.  |..|
FGVLMWEIFT
Kinase IRAK-Un_bv.AA MLK 76-275 24 4.7e-25 83.93 In-house 3-233 (291) Show / Hide 
Range on Protein: 76-275
Range on HMM: 3-233/291
Sequence Identity: 24% (57 aa)

EHNLLGTGGFGKVYRGILPGEN---SPVAIKKMVR------DSHQGEREFLAELQIISKRSHRN----LVPLRGWHCARDHRELVLVYDYMPQGSVESAL
.|  .| |.||||..|   ...     ||.|.         |.    ..|  |  . .. ||.|     ....|  |...  ....|  |.. ||  . |
FHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGV-CLQPPCHFCIVMEYCEGGSLYNVL

FHKGDALL-----------LLWDARLRILSGLAAALIYLHEDWEQQVIHRDVKCSNVMLDE------EFRARLGDFGLARTASHDVSSRTTTLAGTLGYI
  . .                 |  ...    | .. |||..  ...|||| | .|...||      .  ..  |||..|  ..   .  .  |||. . 
HGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYAWM

APEV---GVTYKFTPASDVYSYGVVTLEVVTGR
||||       |.. ..||.|.|||  |..|..
APEVIQQFRCEKYSEKCDVWSWGVVLWEMLTRE
Kinase IRAK-Un_bv.AA Dicty4 77-274 30 1.8e-23 75.32 In-house 4-213 (277) Show / Hide 
Range on Protein: 77-274
Range on HMM: 4-213/277
Sequence Identity: 30% (66 aa)

HNLLGTGGFGKVYRGILPGENSPVAIKKM----VRDSHQGEREFLAELQIISKRSHRNLVPLRGWHCA--RDHR-ELVLVYDYMPQGSVESALFHK----
 ...|.|.||.||.|.  |    ||.||.    . ..     ||..|  | .| .| |.. . |  |   | |  ... |  |||.|...| | |.    
EQRIGKGSFGEVYKGTWRGKE--VAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMG-ACTAPRSHPGKMCIVTEYMPKGNLYS-LLHDKPSE

-GDALLLLWDARLR-ILSGLAAAL--IYLHE-DWEQQVIHRDVKCSNVMLDEEFRARLGDFGLAR-TASHDVSSR-TTTLAGTLGYIAPEVGVTYKFTPA
  .   | |  ..| .. .. ||.  ..||. .    .|||| | .| . |. .|.  .||||..    |   .  ..| .|| .. |||| .   .. .
QQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCN--PVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEK

SDVYSYGVVTLEVVTG
.||||.| |  | .|.
ADVYSFGIVLWEILTR
Kinase IRAK-Un_bv.AA Dicty4-Unclassified 77-274 27 2.3e-23 76.88 In-house 4-204 (263) Show / Hide 
Range on Protein: 77-274
Range on HMM: 4-204/263
Sequence Identity: 27% (58 aa)

HNLLGTGGFGKVYRGILPGENSPVAIKKMVRDSHQGE----REFLAELQIISKRSHRNLVPLRGWHCA-RDHRE-LVLVYDYMPQGSVESALFH-----K
   .| | | ||..|.  | .  ||.||.   . .       .|..|  |    .| ||| ..|   . | |.  .. |   |..|     . |     .
DQFIGKGHFSKVHKGNWKGKD--VAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNL-FEVIHSKPSEQ

GDALLLLWDARLRILSGLAAALIYLHEDWEQQVIHRDVKCSNVMLDEEFRARLGDFGLARTASHDVSSRTTTLAGTLGYIAPEVGVTYKFTPASDVYSYG
   . |     ...    |  . .||      .||||.| ||...|  | .. .|||..|  .       || |||    .||.     .. .||||||.
QQPIKLDDTLIIKYAFDIAQGMQHLH---TRNFIHRDIKSSNILMDKHFNIKIADFGISRVIDFNFN--MTTIAGTPKWESPECLMHESYNQKSDVYSYA

VVTLEVVTG
..  | .||
MMLYELATG
Kinase IRAK-Un_bv.AA LISK-DD1 173-277 33 1.9e-18 63.46 In-house 122-230 (290) Show / Hide 
Range on Protein: 173-277
Range on HMM: 122-230/290
Sequence Identity: 33% (38 aa)

WDARLRILSGLAAALIYLHEDWEQQVIHRDVKCSNVMLDEE----FRARLGDFGLARTASHDVSS---RTTTLAGTLGYIAPEVGVTYKFTPASDVYSYG
|. |..|  ..|.|  |||   . ..|||| |  |  .||      |... |||.||... .  .   |. |  || .  |||| .  .   ..||.|.|
WKLRVKIALDIACAMAYLH---SKNIIHRDLKSKNILVDENGDSQWRIKVCDFGFARMFEQKKNQQNNRHMTICGTDNWMAPEVILGMSYDWSCDVFSFG

VVTLEVVTGRRV
.| ||  |....
MVLLELITRKKP
Kinase IRAK-Un_bv.AA TyrKc 76-312 22 1.2e-15 30.06 SMART 3-280 (280) Show / Hide 
Range on Protein: 76-312
Range on HMM: 3-280/280
Sequence Identity: 22% (66 aa)

EHNLLGTGGFGKVYRGILPGENSPVAIKKMVRDSHQGEREFLAELQIISKR--SHRNLVPLRGWHCARDH-------RELVLVYDYMPQGSVESAL-FHK
    || | ||.||.|..     .||.|..  |.   ...|. |..| .|   .| |.| | |  .....         | .|  ||| |.  . |  |.
LGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYG--VCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

GDALLLLWDARLRILSGLAAALIYLHEDWEQQVIHRDVKCSNVMLDEEFRARLGDFGLARTASHD----VSSRTTTL----AGT----LGYIAPEVGVTY
..   | ..  | .    |.   |||.    ..||||  . |....|..... .||||.|   .|    .|. . .      |     .   |||.  ..
PK---LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

KFTPASDVYSYGVVTLEVVTGRRVIGSSKEKD-----HNAWLLVPWVEEQYAAGKLLG--------------------------------VVDPRL
|||..|||.|.||.  |. |     | .   .      ..  .. .|.. |   .                                    .  ..
KFTTKSDVWSFGVCMWEIFTY----GQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase IRAK-Un_bv.AA LISK-DD1 79-104 57 6.8e-05 13.89 In-house 1-24 (290) Show / Hide 
Range on Protein: 79-104
Range on HMM: 1-24/290
Sequence Identity: 57% (15 aa)

LLGTGGFGKVYRGILPGENSPVAIKK
  | |.|||||.| . |  .||||||
EIGKGSFGKVYKGCYFG--TPVAIKK