Gene IRAK-Un_ay-1 (S.moellendorffii)

IRAK-Un_ay-1

Species: S.moellendorffii
Alias: IRAK-Un_ay-1
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
IRAK-Un_ay-1.AA Protein None 326 None Fasta, JSON
IRAK-Un_ay-1.NA RNA None 981 None Fasta, JSON
IRAK-Un_ay-1.kin_dom Protein Kinase Domain None 190 None Fasta, JSON

Protein domain

Protein domains of IRAK-Un_ay-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IRAK-Un_ay-1.AA TKL 23-282 18 2e-50 173.82 In-house 28-364 (364) Show / Hide 
Range on Protein: 23-282
Range on HMM: 28-364/364
Sequence Identity: 18% (67 aa)

VVAVKYLTS-------------------------SDLSEKARLDFENEVSTISLLQHKNVVKLFGFCSEKEH-------------KLIVCELVENGNLSD
.|||| . |                         .. ....|  .|.|.  .| |.| |.|.. |.| . ..               || |....|.| .
DVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLH

ALFEIMKRVSSISVWKDLQLDWTARYNICVGVAQGLAYLHGET---SQAT--IVHRDIKALNILLASDLK--------------PKISDFGLARLIQQSR
 |                   |  | ... ..|.|..||| ..   .. .  |.|||.|  |||. ....              .||.||||.| ..|| 
YLH------------------WHQRCRWALDIARGMNYLHSMNPKWCT-KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSG

SYTSTR------------------AAGTAGYLAPEYAL----------------SGQLTEKADVYSFGILVLEIISGRKNMDFTLLDSEFFLLEWAWN--
. . |                     || ...|||                   ... .||.|||||||.  ||.....        ...   .. ..  
NMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR------PYYDYPYMPMIFQDP

--AFQSGNLQEIIDKRLE--------VGDQEIHEIKRVFTVALHCTQASQNKRPVMYRVVGML
  ...... ..     .         .  .. .  ...   . .| ..  .||| . ...  |
FEEMFMMVCDKGLRPPIPPIWQNHHKM-CPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAK-Un_ay-1.AA TK 22-207 18 1.2e-34 113.07 In-house 53-389 (486) Show / Hide 
Range on Protein: 22-207
Range on HMM: 53-389/486
Sequence Identity: 18% (64 aa)

HVVAVKYLTS-SDLSEKARLD--------------FENEVSTIS--LLQHKNVVKLFGFCSEK------------EHKLIVCELVENGN----LSDALFE
. |||| |.. .. |.....|              . .| .  .  |..|.|.|.|.| |...            |. .|| |....|.    | | | .
TPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRK

IMKRVS----------------------------------------------------SISVWKDLQ------------LDWTARYNICVGVAQGLAYLH
  .. .                                                    ... .  ||            |.   .  .|. .|.|..|||
CRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLH

GETSQAT---IVHRDIKALNILLASDLK-----------PKISDFG--------LARLIQQSRSYTSTRAAGTAG-------------------------
    .     .||||. | |.|......            ||.|||        ||| |...  |....  ||..                         
SKNCE-FIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIR

YLAPEYALSGQ---------LTEKADVYSFGILVLEIIS
..|||  ....          |.| ||.|||.|. || .
WMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFT
Kinase IRAK-Un_ay-1.AA MLK 23-209 27 2.3e-34 116.64 In-house 29-233 (291) Show / Hide 
Range on Protein: 23-209
Range on HMM: 29-233/291
Sequence Identity: 27% (57 aa)

VVAVKYLTSSDLSEKAR-----LDFENEVSTISLLQHKN----VVKLFGFCSEKEH-KLIVCELVENGNLSDALFEIMKRVS---SISVWKDLQLDWTAR
.||||  ...   .|..      ||| |.   . |.|.|    .... | |.. ..  .|| | .|.| |.. | .. .  .         |   |    
IVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQK-NDRVYDHDHA

YNICVGVAQGLAYLHGETSQATIVHRDIKALNILLAS------DLKPKISDFGLARLIQQSRSYTSTRAAGTAGYLAPEY---ALSGQLTEKADVYSFGI
 |... .|.|..||| .  . .|.|||.|  |||..       ... ||.|||..| ..|.   . . .|||. . |||    . ... .||.||.|.|.
MNWALQCARGMHYLHSMA-PKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGV

LVLEIISGR
.  |.....
VLWEMLTRE
Kinase IRAK-Un_ay-1.AA TKL-Unique 24-208 29 2.3e-34 118.67 In-house 23-224 (290) Show / Hide 
Range on Protein: 24-208
Range on HMM: 23-224/290
Sequence Identity: 29% (62 aa)

VAVKYLT-SSDLSEKARLDFENEVSTISLLQ-HKNVVKLFGFCS----EKEHKLIVCELVENGNLSDALFEIMKRVSSISVWKDLQLDWTARYNICVGVA
||.| .   .|.| . . .|||||.... |. |.|.|...|.|        .  ||.| .. |.| | |        .    . . |..  |...   .|
VAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNN--NNNNNNNCKLNMQQRVKMAIDIA

QGLAYLHGETSQATIVHRDIKALNILLASD-----LKPKISDFGLARLIQQSRSYTSTRA--------AGTAGYLAPEYALSG---QLTEKADVYSFGIL
||. |||  .....| |||.| .|.|. ..     .. ||.||||...  ..   |...          |.. ..|||  |..   | .||.||||||| 
QGMYYLH--HCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEV-LRMNFCQYSEKSDVYSFGIV

VLEIISG
. ||...
LWEIATR
Kinase IRAK-Un_ay-1.AA IRAK 104-213 39 8.1e-33 113.69 In-house 106-225 (317) Show / Hide 
Range on Protein: 104-213
Range on HMM: 106-225/317
Sequence Identity: 39% (47 aa)

LDWTARYNICVGVAQGLAYLHGETSQATIVHRDIKALNILLASDLKPKISDFGLARLI--QQSRSYTST------RAAGTAGYLAPEYAL--SGQLTEKA
| |  |  || | | |. .||   .   | |.|||  ||||  .. |||.||||.|     ... ...       .  ||. |..||.    .|||| | 
LSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQLTKKT

DVYSFGILVLEIISGRKNMD
||||||| .||...|.. ..
DVYSFGIVLLEVLTGCRAVY
Pkinase IRAK-Un_ay-1.AA Pkinase 20-209 25 1.7e-32 115.95 Pfam 23-209 (293) Show / Hide 
Range on Protein: 20-209
Range on HMM: 23-209/293
Sequence Identity: 25% (53 aa)

DSHVVAVKYLTSSDLSEKAR-----LDFENEVSTISLLQHKNVVKLFGFCSEKEHKLIVCELVENG----NLSDALFEIMKRVSSISVWKDLQL--DWTA
....|||| .  .. ... .     |   .|..    |.|.|.|.|.... .| |  .| |..|.|     |.| .            |..  .  ..  
TGKIVAVKIIKKRHEKSWKDQTHRRL---SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST----------WRHGCFYFSEWE

RYNICVGVAQGLAYLHGETSQATIVHRDIKALNILLASDLKP----KISDFGLARLIQQSRSYTSTRAAGTAGYLAPEYAL-SGQLTEKADVYSFGILVL
  ...  ...||.|.| .     |.|||.|  |||. ..  .    ||.|||||....  ..   |  .|| .|.|||  . .   . |.|..|.|... 
CKFYMYQILRGLEYCHSM----GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILY

EIISGR
| ..||
EMLCGR
Kinase IRAK-Un_ay-1.AA Dicty4 24-201 29 1e-31 103.19 In-house 25-206 (277) Show / Hide 
Range on Protein: 24-201
Range on HMM: 25-206/277
Sequence Identity: 29% (55 aa)

VAVKYL--TSSDLSEKARLDFENEVSTISLLQHKNVVKLFGFCS----EKEHKLIVCELVENGNLSDALFEIMKRVSSISVWKDLQLDWTARYN---ICV
|||| |  .  ...|.   .| .||.  . ..| |.... | |     ...  .|| |..  ||    |...     |    .  .|||. .     .. 
VAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGN----LYSLLHDKPS-EQQQSIKLDWPLIKRAMRMAF

GVAQGLAYLHGETSQATIVHRDIKALNILLASDLKPKISDFGLARLIQQSRSYTS--TRAAGTAGYLAPEYALSGQLTEKADVYSFGIL
 .|.|...||.  .   |.|||.|. |.|   ... |..||||.....   . .   . |.||... |||   .   .||||||||||.
DAARGMNWLHC--CNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADVYSFGIV
Kinase IRAK-Un_ay-1.AA Pkinase_Tyr 24-210 32 1.8e-29 100.43 Pfam 31-213 (270) Show / Hide 
Range on Protein: 24-210
Range on HMM: 31-213/270
Sequence Identity: 32% (64 aa)

VAVKYLTSSDLSEKA--RLDFENEVSTISLL-QHKNVVKLFGFCS-EKEH--KLIVCELVENGNLSDALFEIMKRVSSISVWKDLQLDWTARYNICVGVA
|||| |   . ....  | || .|... . | .|.|.|.| | |. ..|.   .|| |....|.| | |    .|        . .|.     ..|. .|
VAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL--RKHR------EDKQPLTMKDLLQMCWQIA

QGLAYLHGETSQATIVHRDIKALNILLASDLKPKISDFGLARLIQQSRSYTSTRAAGTAG----YLAPEYALSGQLTEKADVYSFGILVLEIIS-GRK
.|..||.       ..|||. | |.|...... ||.||||||.| .. .|  .|..| .      .|||    |  |.| ||.|||.|  ||.. |..
KGMEYLESKN----CIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQ
Kinase IRAK-Un_ay-1.AA LISK 23-210 25 2.4e-29 92.35 In-house 21-237 (296) Show / Hide 
Range on Protein: 23-210
Range on HMM: 21-237/296
Sequence Identity: 25% (58 aa)

VVAVKYLTS----SDLSEKARLDFENEVSTISLLQHKNVVKLFGFCSE-KEHKLIVCELVENGNLSDALFEIMKRVSSISVWKDLQLDWTARYNICVGVA
|.|.| ...    ... | ..  .. || .. .|.|.|.|. .| | . . .  || |... |.| . |.   |        .. .| |. | .| ...|
VMAIKMIHRQPNDPNDPE-YQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDK--------HKIPLPWPQRVKIALDIA

QGLAYLHGETSQATIVHRDIKALNILLA----SDLKPKISDFGLARLIQQSR---------------------------SYTSTRAA------GTAGYLA
.|..|||       |.||| |. |.|.     .. . |. |||.||......                           .. . ..       ||.   |
CGMSYLH----SMNIIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESDPCMDNDMPMKRKIPKKCMNQRKRRMTICGTPYWMA

PEYALSGQLTEKADVYSFGILVLEIISGRK
||  |  . .|..||.||||...||| ..|
PEMLLGQSYDESCDVFSFGIVLCEIITRVK
Kinase IRAK-Un_ay-1.AA Dicty4-Unclassified 24-208 33 2e-27 90.96 In-house 25-204 (263) Show / Hide 
Range on Protein: 24-208
Range on HMM: 25-204/263
Sequence Identity: 33% (64 aa)

VAVKYLTSSDLSEKAR----LDFENEVSTISLLQHKNVVKLFGFC----SEKEHKLIVCELVENGNLSDALFEIMKRVSSISVWKDLQLDWTARYNICVG
|||| . .   . |.|     ||  ||    ..|| | ||. | |    | |    || |.   ||    |||.     |    . ..|| |    .   
VAVKKFNEN--KFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGN----LFEVIHSKPS-EQQQPIKLDDTLIIKYAFD

VAQGLAYLHGETSQATIVHRDIKALNILLASDLKPKISDFGLARLIQQSRSYTSTRAAGTAGYLAPEYALSGQLTEKADVYSFGILVLEIISG
.|||...||       ..|||||. |||.  .   || |||..| |  .  .. |  |||    .||       . |.||||....  | . |
IAQGMQHLH----TRNFIHRDIKSSNILMDKHFNIKIADFGISRVI--DFNFNMTTIAGTPKWESPECLMHESYNQKSDVYSYAMMLYELATG
Kinase IRAK-Un_ay-1.AA LISK-DD1 45-210 26 1e-25 90.08 In-house 44-229 (290) Show / Hide 
Range on Protein: 45-210
Range on HMM: 44-229/290
Sequence Identity: 26% (54 aa)

EVSTISL---LQHKNVVKLFGFCSE-------------KEHKLIVCELVENGNLSDALFE----------IMKRVSSISVWKDLQLDWTARYNICVGVAQ
|....     ..|.|.|. .| | .             .    || |..| |.| ..|.           |          .. .. |. | .| ...|.
EIKMLKNLLNIRHPNIVQFIGICEHPLASPSLVNRLLNESSLYIVTEFIEGGDLHWYLKNTPFDDTPEQYIH---------HKIPIPWKLRVKIALDIAC

GLAYLHGETSQATIVHRDIKALNILLASD----LKPKISDFGLARLIQQS------RSYTSTRAAGTAGYLAPEYALSGQLTEKADVYSFGILVLEIISG
. ||||       |.||| |. |||..       . |. |||.|| ..|.      |..|     || .  |||  |  .  . .||.|||.. ||.|..
AMAYLHSK----NIIHRDLKSKNILVDENGDSQWRIKVCDFGFARMFEQKKNQQNNRHMT---ICGTDNWMAPEVILGMSYDWSCDVFSFGMVLLELITR

RK
.|
KK
Kinase IRAK-Un_ay-1.AA STE 112-209 26 5.9e-22 74.39 In-house 156-265 (359) Show / Hide 
Range on Protein: 112-209
Range on HMM: 156-265/359
Sequence Identity: 26% (32 aa)

ICVGVAQG-LAYLHGETSQATIVHRDIKALNILLASDLKPKISDFGLARLIQQ---------------SRSYTSTRAAGTAGYLAPEYALS------GQL
||. . .| |.|||       |.|||||. ||||      |..|||..  ...               ...  ..  .||  . |||  .       .. 
ICRQILKGLLYYLHSHH----IIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGY

TEKADVYSFGILVLEIISGR
..|.|..|.|....| . |.
DTKCDIWSLGCTIIEMATGK
TyrKc IRAK-Un_ay-1.AA TyrKc 10-282 21 3e-17 56.15 SMART 1-280 (280) Show / Hide 
Range on Protein: 10-282
Range on HMM: 1-280/280
Sequence Identity: 21% (67 aa)

IVDTHT----------QGVIDSHVVAVKYLTSSDLSEKARLDFENEVSTISLL--QHKNVVKLFGFCSEK-------EHKLIVCELVENGNLSDAL-FEI
|.  ..          .|. .   |||| | ..      | || .| .  . |  .|.|.|.|.| |...       |  .|| |....|.| | |    
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

MKRVSSISVWKDLQLDWTARYNICVGVAQGLAYLHGETSQATIVHRDIKALNILLASDLKPKISDFGLARLIQQS-------RSYT-----STRAAGTAG
 |            | .    ..|. .|.| .|||       ..|||. | |.|.....  |||||||.| |            |.     ....     
PK------------LCMKDLLSFCWQIACGMEYLHSK----NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIR

YLAPEYALSGQLTEKADVYSFGILVLEIISGRKNMDFTLLDSEFFLLEWAWNAFQSGNLQEIIDKRLEVGDQEIHEI------KRVFTVALHCTQASQNK
 .|||    |  |.| ||.|||..  || .  .          .   . . .  ..|.  .. .  .        ..      . .... . | ..  ..
WMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDY--------PMSFVCCPDEMYQIMKQCWHEDPED

RPVMYRVVGML
|| .  ..  .
RPTFSEIHECF
S_TKc IRAK-Un_ay-1.AA S_TKc 3-258 19 3.8e-14 30.52 SMART 1-231 (231) Show / Hide 
Range on Protein: 3-258
Range on HMM: 1-231/231
Sequence Identity: 19% (56 aa)

FLTEKN----------SIVDTHTQGVIDSHVVAVKYLTSSDLSEKARLDFENEVSTISLLQHKNVVKLFGFCSEKEHKLIVCELVEN--GNLSDALFEIM
.   .             ....     . ..||.| .           ....|..  .  .|.|.|||.... . .|  .| |....  |.| | . .  
YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG

KR-----VSSISVWKDLQLDWTARYNICVGVAQGLAYLHGETSQATIVHRDIKALNILLASDLKPKISDFGLARLIQQSRSYTSTRAAGTAGYLAPEYAL
..      .   ...           ..  ....|.|.|   |.  |.|||.|  |||| .    ||.||||||..        |   ||  |.|||   
RHGLRFPFPE-HARF-----------YMYQICCALEYCH---SH-GIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL-

SGQLTE-KADVYSFGILVLEIISGRKNMDFTLLDSEFFLLEWAWNAFQSGNLQEIIDKRLEV------GDQEIHE------IKRVF
  . .  |.|..|.|... | ..|.   .   ..  | ..        |  . ..|.| |..      .  |. .      .   |
--GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG-------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAK-Un_ay-1.AA STE 23-86 14 5e-06 17.34 In-house 41-128 (359) Show / Hide 
Range on Protein: 23-86
Range on HMM: 41-128/359
Sequence Identity: 14% (13 aa)

VVAVKYLTSSDLS---------------EKARLDFENEVSTISLLQ--HKNVVKLFGFCSEK-------EHKLIVCELVENGNLSDAL
..|.| .  .. .               .. . ....|... . ..  |.|.|| .| .  .       ..  |. |....| |.| .
IMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDII
Kinase IRAK-Un_ay-1.AA IRAK 44-84 34 0.000575 10.14 In-house 52-92 (317) Show / Hide 
Range on Protein: 44-84
Range on HMM: 52-92/317
Sequence Identity: 34% (14 aa)

NEVSTISLLQHKNVVKLFGFCSEKEHKLIVCELVENGNLSD
||. . ....|.|.| | |.|.| .    | ..  || | |
NELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLED