Gene IRAK-Un_r (S.moellendorffii)

IRAK-Un_r

Species: S.moellendorffii
Alias: IRAK-Un_r
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
IRAK-Un_r.AA Protein None 397 None Fasta, JSON
IRAK-Un_r.NA RNA None 1194 None Fasta, JSON
IRAK-Un_r.kin_dom Protein Kinase Domain None 156 None Fasta, JSON

Protein domain

Protein domains of IRAK-Un_r.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IRAK-Un_r.AA TKL 24-259 20 3.4e-54 186.37 In-house 27-364 (364) Show / Hide 
Range on Protein: 24-259
Range on HMM: 27-364/364
Sequence Identity: 20% (72 aa)

KPLALKKSRAGD-------------------------------KSLVKELSLLARLHHAYLVNLVGYCAQEQ---------------LLAFEFMENGSLF
|. | || .  .                               . ...|. .. ||.|  .| ..||| ...                .  |....|||.
KDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLL

DCLFKKPEIRLDWFLRIRIAAQAARGLEYLHIYAS-----PQILHRDVKAANILLDKDWN--------------AHLSDFGFSLSPSGNTTQLATM----
. |         | .|.|.| ..|||..|||         |.|.||| | .|||.|..|.              . ..|||.| . |... . .||    
HYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMM

---------------VGTPGYMDPEYFQTA----------------KFTTKSDVYSFGVVLLELLTGRQAMLGSERSLVS------WVLLQRGKSNTCSL
               .|||..| || .. .                ....|.||||||.|| |.||...   .   . .       . . .... .   .
ESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPP

FDPRIFL----PENSAALEEVLRLALQCTSFDAEHRPTISSIATTL
 .|.       . .. ..... .|. .| . |.| ||. . |  .|
IPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAK-Un_r.AA TKL-Unique 40-192 29 4.8e-40 138.92 In-house 44-226 (290) Show / Hide 
Range on Protein: 40-192
Range on HMM: 44-226/290
Sequence Identity: 29% (54 aa)

KELSLLARLH-HAYLVNLVGYCA----QEQ--LLAFEFMENGSLFDCLFK--------KPEIRLDWFLRIRIAAQAARGLEYLHIYASPQILHRDVKAAN
.|.... .|| |. .| ..|||.    ..    .  |... ||| | |          .... |.. .|...| ..|.|..||| .  | |.||| |  |
NEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSN

ILLDKD-----WNAHLSDFGFSLSPSGNTTQLATM---------VGTPGYMDPEYFQT--AKFTTKSDVYSFGVVLLELLTGRQ
.|.| .     ||. ..|||.| . | ...  ...         .|.. .| || .    .....||||||||.|| |..|. .
FLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATRKI
Kinase IRAK-Un_r.AA IRAK 39-195 36 8.7e-39 135.12 In-house 51-225 (317) Show / Hide 
Range on Protein: 39-195
Range on HMM: 51-225/317
Sequence Identity: 36% (64 aa)

VKELSLLARLHHAYLVNLVGYCAQEQL--LAFEFMENGSLFDCLF-KKPEIR---LDWFLRIRIAAQAARGLEYLHIYASPQ--ILHRDVKAANILLDKD
..|| ...|..|. .| | |||...|   | ...| ||||.| |   ..      | |  |. |.  .|.|...||  ..|   | |.|.| ||||||..
YNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQCPPKPLSWHQRCSICWGTACGIQFLH-QNHPCTPIIHGDIKSANILLDQH

WNAHLSDFGFSLSP---SGNTTQLA------TMVGTPGYMDPEYFQ--TAKFTTKSDVYSFGVVLLELLTGRQAML
 .. ..|||    .   |..  |        . .||  || ||.    . . |.|.||||||.||||.|||. |..
FTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQLTKKTDVYSFGIVLLEVLTGCRAVY
Kinase IRAK-Un_r.AA Dicty4 69-190 38 8.8e-37 120.32 In-house 82-213 (277) Show / Hide 
Range on Protein: 69-190
Range on HMM: 82-213/277
Sequence Identity: 38% (52 aa)

EFMENGSLFDCLFK-----KPEIRLDWFLRIR---IAAQAARGLEYLHIYAS--PQILHRDVKAANILLDKDWNAHLSDFGFSL--SPSGNTTQ-LATMV
|.|  |.|.  | .     ...| ||| |..|   .|  ||||. .||   .  | |.||| |..|.| ||.|..  .|||.|    .  . .. . |..
EYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLH---CCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTAC

GTPGYMDPEYFQTAKFTTKSDVYSFGVVLLELLTG
|||..| ||  .   .. |.|||||| || |.||.
GTPCWMAPEVMMHQPYNEKADVYSFGIVLWEILTR
Kinase IRAK-Un_r.AA Pkinase 35-191 28 1.6e-36 130.24 Pfam 42-209 (293) Show / Hide 
Range on Protein: 35-191
Range on HMM: 42-209/293
Sequence Identity: 28% (50 aa)

DKSLVK--ELSLLARLHHAYLVNLVGYCAQEQLLA--FEFMENG----SLFDCLFKKPEIRL--DWFLRIRIAAQAARGLEYLHIYASPQILHRDVKAAN
|.....  |.....||.| . | | ...  .. .   .|..|.|    .||| .  . . ..  ..   .... | .|||||.|      |.|||.| .|
DQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPEN

ILLDKDWNA----HLSDFGFS--LSPSGNTTQLATMVGTPGYMDPEYFQ-TAKFTTKSDVYSFGVVLLELLTGR
||.|.. .     ...|||..  ..   | . . | .|||.|| ||  .   . ..|.|..|.|..| |.|.||
ILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGR
Kinase IRAK-Un_r.AA LRRK 40-194 31 1.7e-35 123.0 In-house 106-283 (351) Show / Hide 
Range on Protein: 40-194
Range on HMM: 106-283/351
Sequence Identity: 31% (57 aa)

KELSLLARLHHAYLVNLVGYCAQEQLLAFEFMENGSLFDCLFKKPE-------IRLDWFLRIRIAAQAARGLEYLHIYASPQILHRDVKAANILL---D-
.|.... .|.| ..|.|.|.| .   .. |.. .|.| . |..| .       ....| |...|| | |.|.||||  ..| |.||| |  ||||   . 
HEVWIMSHLNHPNIVSLKGFCIHPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLH-SHNPPIIHRDLKSPNILLWSSPQ

--------KDWNAHLSDFGFSL--SPSGNTTQLATMVGTPGYMDPEYFQ---TAKFTTKSDVYSFGVVLLELLTGR-QAM
         . .|...||| |   .. ...  . ..||.||.| ||  .   .  .|.|.|.||||..| ||||.. ...
NHSPNYPNAHVCAKIADFGISRMFQCFHMGV-AKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPF
Kinase IRAK-Un_r.AA TK 37-259 17 2.5e-35 115.31 In-house 87-486 (486) Show / Hide 
Range on Protein: 37-259
Range on HMM: 87-486/486
Sequence Identity: 17% (71 aa)

SLVKELSLLA--RLHHAYLVNLVGYCAQE--------------QLLAFEFMENGS----LFDCLFKKPEI------------------------------
... |....    .||  .|.|.|.| |.               ..  |.|..|.    | | | |...                               
EEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITY

--------------------------------------------RLDWFLRIRIAAQAARGLEYLHIY----ASPQILHRDVKAANILLDKDWN------
                                            .|.   .. ...|.|.|.||||        ... |||. | |.|.... .      
SHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFD

-----AHLSDFGFS------LSPSGNTTQLATMVGTPG----------------------------YMDPEYFQ---------TAKFTTKSDVYSFGVVL
     . ..||| |      |.   .  .  . ....|                            .| || ..         . ||||||||.||||..
GCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLM

LELLTGRQAMLGSERS----------LVSWVLLQR------------GKSNTCS--LFDP-----RIFLPENSAALEEVLRLALQCTSFDAEHRPTISSI
 |..|  |.. . . |               .|.|            |  . .      |     |. . ..... ||. .| .|| ..|.|.||| | .
WEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRM-H-PPHCPPEEYYDLMQQCWHYDPEDRPTFSQL

ATTL
   |
HEQL
Kinase IRAK-Un_r.AA RIPK 36-202 28 5.8e-33 109.65 In-house 41-236 (290) Show / Hide 
Range on Protein: 36-202
Range on HMM: 41-236/290
Sequence Identity: 28% (57 aa)

KSLVKELSLLARLHHAYLVNLVGYCAQE--------QLLAFEFMENGSLFDCLFKKPE---IRLDWFLRIRIAAQAARGLEYLHIYASPQILHRDVKAAN
. .  |   ...| . . | . | | .|        . .  |.|||||| . |  |..     . | || |.  . ..|  |||    | |.||| | .|
MYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQHHPDPWPLRCRMIHEISCGMCYLHSMN-PPIIHRDLKPEN

ILLDKDWNAHLSDFGFS----LSPSGN---------TTQLATMVGTPGYMDPEYFQ--TAKF----TTKSDVYSFGVVLLELLTGRQAMLGSERSLV
||.| . .. ..||| .     | |..          .. .   ||  ||.|| |    .|     |.|.|||||..|. |.||.... .. . ...
ILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDNKKPIKVVTPKYDVYSFAIVMWEVLTQKHPYEDRKCMMM
Kinase IRAK-Un_r.AA MLK 39-191 30 1.5e-32 110.31 In-house 56-233 (291) Show / Hide 
Range on Protein: 39-191
Range on HMM: 56-233/291
Sequence Identity: 30% (54 aa)

VKELSLLARLH-HAYLVNLVGYCAQE-Q--LLAFEFMENGSLFDCL---FKKPE---------IRLDWFLRIRIAAQAARGLEYLHIYASPQILHRDVKA
...|. | ..  | . . ..| |.|. .  ..  |..|.|||.. |    .|..         .. |  . ...| | |||..|||  | ..| ||| | 
CRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKS

ANILLD------KDWNAHLSDFGFSLSPSGNTTQLATMVGTPGYMDPEYF---QTAKFTTKSDVYSFGVVLLELLTGR
 |||.|      .. ..  .||| | . . ..|    . ||. .| || .   .  |.. |.||.|.|||| |.||..
HNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTRE
Kinase IRAK-Un_r.AA Dicty4-Unclassified 40-190 34 1.9e-32 108.4 In-house 47-204 (263) Show / Hide 
Range on Protein: 40-190
Range on HMM: 47-204/263
Sequence Identity: 34% (56 aa)

KELSLLARLHHAYLVNLVGYCAQE------QLLAFEFMENGSLFDCLF-----KKPEIRLDWFLRIRIAAQAARGLEYLHIYASPQILHRDVKAANILLD
||  .|  . |  || . |||              |||  | ||         ..  |.||  | |..|   |.|. .||   .  . |||.|..|||.|
KEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQPIKLDDTLIIKYAFDIAQGMQHLH---TRNFIHRDIKSSNILMD

KDWNAHLSDFGFSLSPSGNTTQLATMVGTPGYMDPEYFQTAKFTTKSDVYSFGVVLLELLTG
|. |.   ||| |   . ..  . |  |||    ||      .. ||||||....| ||.||
KHFNIKIADFGISRVID-FNFNMTTIAGTPKWESPECLMHESYNQKSDVYSYAMMLYELATG
Kinase IRAK-Un_r.AA Dicty5 69-189 34 1.7e-28 95.15 In-house 79-198 (260) Show / Hide 
Range on Protein: 69-189
Range on HMM: 79-198/260
Sequence Identity: 34% (43 aa)

EFMENGSLFDCLFKKPE---IRLDWFLRIRIAAQAARGLEYLHIYASPQILHRDVKAANILLDKDWNAHLSDFGFSLSPSGNTTQLATMVGTPGYMDPEY
|.  |||||. |  .       . .|... .|  .|.....||   |  | |||.|  |.|. ..| . . ||| |     |  .  . |||. .| .| 
EYCHNGSLFNYLNDQRKTTGQPIAYFQQLHMAIDIAQSMRHLH---SMNIIHRDLKSMNFLITENWKIKIIDFGTSRF-VDNRYHMTMHVGTQCWMACEL

FQTAKFTTKSDVYSFGVVLLELLT
|.   .. | ||||||.|| |..|
FNGQPYHQKCDVYSFGIVLWEMFT
S_TKc IRAK-Un_r.AA S_TKc 2-264 21 4.2e-28 100.6 SMART 1-231 (231) Show / Hide 
Range on Protein: 2-264
Range on HMM: 1-231/231
Sequence Identity: 21% (60 aa)

GWRSSLLGMGSFHRSFLPRTAE--KPLALKKSRAGDKSLVKELSLLARLHHAYLVNLVGYCA-QEQLLAFEFMEN--GSLFDCLFKKPEIR----LDWFL
     ..| |.| . .. |  .  .  |.|. .   ... .|...| . || ..|.| ...  ..  . .|....  |.||| . |..  .    ..   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-H

RIRIAAQAARGLEYLHIYASPQILHRDVKAANILLDKDWNAHLSDFGFSLSPSGNTTQLATMVGTPGYMDPEYFQTAKFTT-KSDVYSFGVVLLELLTGR
  ....| ...|||.|   | .|.|||.| .|||||.  .  ..|||..           |..||| || || .   .... |.|..|.|..| |.|.|.
ARFYMYQICCALEYCH---SHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGY

QAMLGSERSLVSWVLLQRGKSNTCSLFDPRIFLPENSAALEEVLRLALQCTSFDAEHRPTISSIAT----TLELKTI
             ..... .                    .|.. .  .|  .| |.|||.  . .          .
PPFP------QMQMMFKKIG-------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
TyrKc IRAK-Un_r.AA TyrKc 4-259 25 4e-15 21.84 SMART 3-280 (280) Show / Hide 
Range on Protein: 4-259
Range on HMM: 3-280/280
Sequence Identity: 25% (74 aa)

RSSLLGMGSF---HRSFLPRTAEKPLALKKSR--AGDKSLVKELSLLARL--HHAYLVNLVGYCA---------QEQLLAFEFMENGSLFDCL-FKKPEI
    || | |   ..  .      . | |. .  |  . . .|.... .|  ||  .|.|.|.|          .  .. .|.|..|.| | |  ..|. 
LGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK-

RLDWFLRIRIAAQAARGLEYLHIYASPQILHRDVKAANILLDKDWNAHLSDFGFSLSPSGN------TTQLATMV--GTPG-----YMDPEYFQTAKFTT
 | .   . .. |.|.| ||||     .. |||  | |.|....  .  |||| |            .    ..   |. .      | || ... ||||
-LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

KSDVYSFGVVLLELLTGRQAMLGSERS--LVSWVLLQRGKSNTCSLFDPRIFLPENSA------ALEEVLRLALQCTSFDAEHRPTISSIATTL
||||.||||.. |..|  |     .    .    .... |.        |   |.|        . .|. .. .||  .|.| ||| | |   .
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGY------RMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase IRAK-Un_r.AA Pkinase_Tyr 36-139 29 7.8e-15 50.86 Pfam 48-156 (270) Show / Hide 
Range on Protein: 36-139
Range on HMM: 48-156/270
Sequence Identity: 29% (33 aa)

KSLVKELSLLARL-HHAYLVNLVGYCA--QEQ---LLAFEFMENGSLFDCLFKK--PEIRLDWFLRIRIAAQAARGLEYLHIYASPQILHRDVKAANILL
... .|....  | ||  .|.|.| |   .|.   .. .|.|..|.| | | |.  .. .|.    . ...| |.|.|||.   | .. |||. | |.|.
EDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLE---SKNCIHRDLAARNCLV

DKDWNAHLSDFG
...  .  .|||
TENNVVKICDFG
Kinase IRAK-Un_r.AA Pkinase_Tyr 163-192 58 1.9e-07 25.87 Pfam 183-213 (270) Show / Hide 
Range on Protein: 163-192
Range on HMM: 183-213/270
Sequence Identity: 58% (18 aa)

PEYFQTAKFTTKSDVYSFGVVLLELLT-GRQ
|| ... ||||||||.||||.. |..| |.|
PECINYGKFTTKSDVWSFGVLMWEIFTYGEQ
Kinase IRAK-Un_r.AA LRRK 240-261 31 0.222448 0.62 In-house 330-351 (351) Show / Hide 
Range on Protein: 240-261
Range on HMM: 330-351/351
Sequence Identity: 31% (7 aa)

QCTSFDAEHRPTISSIATTLEL
.| . | . ||. |.|  .|. 
HCWQHDPKKRPHFSQIVKRLSQ
Kinase IRAK-Un_r.AA Pkinase_Tyr 232-259 42 1.133075 2.9 Pfam 243-270 (270) Show / Hide 
Range on Protein: 232-259
Range on HMM: 243-270/270
Sequence Identity: 42% (12 aa)

EEVLRLALQCTSFDAEHRPTISSIATTL
.|. .| .||  .|.|.||| | |   |
DEIYDLMKQCWHYDPEDRPTFSEIHEQL