Gene IRAK-Un_bx-1 (S.moellendorffii)

IRAK-Un_bx-1

Species: S.moellendorffii
Alias: IRAK-Un_bx-1
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
IRAK-Un_bx-1.AA Protein None 710 None Fasta, JSON
IRAK-Un_bx-1.NA RNA None 2133 None Fasta, JSON
IRAK-Un_bx-1.kin_dom Protein Kinase Domain None 489 None Fasta, JSON

Protein domain

Protein domains of IRAK-Un_bx-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IRAK-Un_bx-1.AA TKL 117-266 22 1.3e-37 131.31 In-house 1-208 (364) Show / Hide 
Range on Protein: 117-266
Range on HMM: 1-208/364
Sequence Identity: 22% (49 aa)

LGQGGFGSVFKGTLKN---------GQHIAVKKLDTASLQG--------------------------EREFMNELSIMGSMASSPFVVGLIGFCAETKR-
.|.|||| |.||....         |. .||||. . . .                           .|.| .|   | |. . | .| ..|.| . .  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------KMLVYEFMANRSLQEVLFDEKHSVVLQWERRAKIVADVARALAFLHG------KCEPPIVHGDVKPSNVLLGADFG------------
             ..|.|.. . || ..|          |..| ... |.||....||       .  |||.| | |..|.|.  ..             
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCT-KPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD

--AKLADFGLARVKTQES
  .|..||||.|...|..
WCCKICDFGLSRFMSQSG
Kinase IRAK-Un_bx-1.AA TKL-Unique 113-588 12 3e-33 114.64 In-house 1-218 (290) Show / Hide 
Range on Protein: 113-588
Range on HMM: 1-218/290
Sequence Identity: 12% (64 aa)

DSHKLGQGGFGSVFKGTLKNGQHIAVKKLDT---ASLQGEREFMNELSIMGSMASSPFVVGLIGFCA----ETKRKMLVYEFMANRSLQEVLFD------
.. |.|.||.|.|.||.  .|  .|.|..      |.. ..|| ||...|     .|..| ..|.|.      ..  .| |..   || .|| .      
FWNKIGEGGYGQVYKGKW-RGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

-EKHSVVLQWERRAKIVADVARALAFLHGKCEPPIVHGDVKPSNVLLGAD-----FGAKLADFGLARVKTQESAAVDERERNDDFGKLSRGGAATPSSIG
  . .  | ...| |.. |.|... .||  ||||| |.| |.||.|.  .     . .|..||||.........    .  .                  
NNNNNCKLNMQQRVKMAIDIAQGMYYLHH-CEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTR----------------

GGQDDDEEWSKLSQSAYGTEADTWSKISPSEIDCRSEISFDGTGQGQAGIKNFLGRKKPWGQRKASASPSSGNGKNSNNGSRDWWWKQESSGQQGGGGGE
                                                                                                    
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FSIREYIVDWVSCENRRGRSRTREWPWNAASSGTAGAAAAGTSSEGKNNVKKKKKQARSGSLEWWAECDDDDELAKRIKAEQKRKKNREWWSGEMQRGKE
                                                                                                    
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WWSGELTSNETNNNNRKGGRLFETWSRESLSGELTRRRRRERSRSHSRDWWSGDLVSRVSSTPSMRGTVCYVAPEYGGG--GVLTEKSDVYSFGVLL
                                                              ..  |.  ..|||   .     .|||||||||. |
-------------------------------------------------------------NQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVL
Kinase IRAK-Un_bx-1.AA IRAK 111-260 33 9.8e-33 113.4 In-house 1-161 (317) Show / Hide 
Range on Protein: 111-260
Range on HMM: 1-161/317
Sequence Identity: 33% (54 aa)

FSDSHKLGQGGFGSVFKGTLKNGQ-HIAVKKLDTASLQGEREFMNELSI----MGSMASS--PFVVGLIGFCAETKRKMLVYEFMANRSLQEVLFDEKHS
|. ....|.|||| |..| .||     |||||       . | . ..      . ....   | .| | |.|.|.    |||..|.| ||.  |   . .
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

VV---LQWERRAKIVADVARALAFLHGKC-EPPIVHGDVKPSNVLLGADFGAKLADFGLAR
.    | | .|..|    |... ||| .    || |||.|..|.|| ..| .|..||||.|
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHR
Kinase IRAK-Un_bx-1.AA Pkinase 111-272 20 1.6e-30 108.98 Pfam 1-171 (293) Show / Hide 
Range on Protein: 111-272
Range on HMM: 1-171/293
Sequence Identity: 20% (36 aa)

FSDSHKLGQGGFGSVFKGTLKNGQH-IAVKKLDTASLQGEREFMN-----ELSIMGSMASSPFVVGLIGFCAETKRKMLVYEFMANR----SLQEVLF--
.    |.|.|.||.|.|.. |. ..  |||...    . . . ..     |..|| .. ..|..| |.... . ..  .| |.. .     .| ...   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW

DEKHSVVLQWERRAKIVADVARALAFLHGKCEPPIVHGDVKPSNVLLGADFGA----KLADFGLARVK-TQESAAVDER
...    ....   ...  ..|.|...| .    |.| |.||.|.|.  .       |..|||||... .  .   . .
RHGCFY-FSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTF
Kinase IRAK-Un_bx-1.AA CAMK 116-595 8 5e-29 90.09 In-house 1-331 (425) Show / Hide 
Range on Protein: 116-595
Range on HMM: 1-331/425
Sequence Identity: 8% (54 aa)

KLGQGGFGSVFKGTLK-NG------------QHIAVKKLDTASLQ----------------------------GEREFMNELSIMGSM------ASSPFV
.||.|.|| |.... | ..            |. |.| .|.  |.                             ......|..|| ..       . | .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VGLIGFCAE-----------TKRK---------MLVY---EFMANR----SLQEVLFDEKH------------SVVLQWERRAKIVADVARALAFLHGKC
. |. .              | .|          .|    |.. .      | . . . ..            .  .. .  ....  .. |....| . 
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

EPPIVHGDVKPSNVLLGADF----------------G-AKLADFGLARVKTQES---------------AAVDERERNDDFGKLSRGGAATPSSIGGGQD
   ||| | || |.||  ..                .  |..|||.|..... .               . .                            
---IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQ-W----------------------------

DDEEWSKLSQSAYGTEADTWSKISPSEIDCRSEISFDGTGQGQAGIKNFLGRKKPWGQRKASASPSSGNGKNSNNGSRDWWWKQESSGQQGGGGGEFSIR
                                                                                                    
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EYIVDWVSCENRRGRSRTREWPWNAASSGTAGAAAAGTSSEGKNNVKKKKKQARSGSLEWWAECDDDDELAKRIKAEQKRKKNREWWSGEMQRGKEWWSG
                                                                                                    
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ELTSNETNNNNRKGGRLFETWSRESLSGELTRRRRRERSRSHSRDWWSGDLVSRVSSTP-------SMRGTVCYVA-PEYGGG--------------GVL
                                                        .||        . || .|.| ||   |                 
--------------------------------------------------------TTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYY

TEKSDVYSFGVLLLVVVSGR
..|.|. | ||.| . ..|.
GPKCDMWSCGVILYIMLCGY
Kinase IRAK-Un_bx-1.AA S_TKc 111-671 10 7.3e-28 99.8 SMART 1-231 (231) Show / Hide 
Range on Protein: 111-671
Range on HMM: 1-231/231
Sequence Identity: 10% (59 aa)

FSDSHKLGQGGFGSVFKGTLKN-GQHIAVKKLDTASLQGEREFMNELSIMGSMASSPFVVGLIGFCAETKRKMLVYEFMAN--RSLQEVLFDEKHS---V
.    |.|.|.||.|.|.. |. |.. |.|...       . ...|..|. .    |..| |.... . ..  .| |.. .   .| ... . ..    .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

VLQWERRAKIVADVARALAFLHGKCEPPIVHGDVKPSNVLLGADFGAKLADFGLARVKTQESAAVDERERNDDFGKLSRGGAATPSSIGGGQDDDEEWSK
..   . ..... ...||...| .    |.| |.||.|.||      |..||||||.                                           
PFPE-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE--HIKICDFGLARQL------------------------------------------

LSQSAYGTEADTWSKISPSEIDCRSEISFDGTGQGQAGIKNFLGRKKPWGQRKASASPSSGNGKNSNNGSRDWWWKQESSGQQGGGGGEFSIREYIVDWV
                                                                                                    
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SCENRRGRSRTREWPWNAASSGTAGAAAAGTSSEGKNNVKKKKKQARSGSLEWWAECDDDDELAKRIKAEQKRKKNREWWSGEMQRGKEWWSGELTSNET
                                                                                                    
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NNNNRKGGRLFETWSRESLSGELTRRRRRERSRSHSRDWWSGDLVSRVSSTPSMRGTVCYVAPEYGGGGVLTEKSDVYSFGVLLLVVVSGRRPLQVVAAP
                                                    .. ||  |.|||    |  ..|.|..|.|..|   ..|. | .     
---------------------------------------------------TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCILYEMLCGYPPFP-----

LSEFERANLISWARHAAQAGRGLDLVDPLLAGAYSKEQATLFISLALLCLQRVPSLRPSMSDVVK---------IF
  ...  ..|                               ....   |||. |. ||.  .. .          |
-QMQMMFKKIG---------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAK-Un_bx-1.AA TK 111-588 9 7.6e-28 89.81 In-house 1-384 (486) Show / Hide 
Range on Protein: 111-588
Range on HMM: 1-384/486
Sequence Identity: 9% (63 aa)

FSDSHKLGQGGFG---SVFKGTLKNG--------------------------QHIAVKKLDTASLQGEREFMN--------------ELSIMGSMAS---
    .|||.| ||    |.||.....                          .  ||| |   . . ..||.               |...|  | .   
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-SPFVVGLIGFCAETKRK------------MLVYEFMANRS----LQEVLFDEKHSVV------------------------------------------
  | .| |.| | . . |            |.| |.|.. .    |.. | . ..                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LQWERRAKIVADVARALAFLHGK---CEPPIVHGDVKPSNVLLGADFG-----------AKLADFGLAR
                               |  ...  . ...|.....|| |    .. .||.|.   |.|.| .             .|.|||||.|
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

VKTQESAAVDERERNDDFGKLSRGGAATPSSIGGGQDDDEEWSKLSQSAYGTEADTWSKISPSEIDCRSEISFDGTGQGQAGIKNFLGRKKPWGQRKASA
...                                                                                                 
QGS-G-----------------------------------------------------------------------------------------------

SPSSGNGKNSNNGSRDWWWKQESSGQQGGGGGEFSIREYIVDWVSCENRRGRSRTREWPWNAASSGTAGAAAAGTSSEGKNNVKKKKKQARSGSLEWWAE
                                                                                                    
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CDDDDELAKRIKAEQKRKKNREWWSGEMQRGKEWWSGELTSNETNNNNRKGGRLFETWSRESLSGELTRRRRRERSRSHSRDWWSGDLVSRVSSTPSMRG
                                                                                       . .|     .   
---------------------------------------------------------------------------------------VLARDIYSDDDYY

TVC-------------------------------YVAPEYGGGGV---------LTEKSDVYSFGVLL
..                                . |||   ..|          |.||||.|||||.
RKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLM
Kinase IRAK-Un_bx-1.AA Pkinase_Tyr 111-260 28 2.3e-26 89.89 Pfam 1-159 (270) Show / Hide 
Range on Protein: 111-260
Range on HMM: 1-159/270
Sequence Identity: 28% (46 aa)

FSDSHKLGQGGFGSVFKGTLK-----NGQHIAVKKL-DTASLQG--EREFMNELSIMGSMASSPFVVGLIGFCAETKRK---MLVYEFMANRSLQEVLFD
 .  .|||.| ||.|.|||.|     .... |||.| ..|. .    ..||.|..|| .. . | .| |.| | . ..    ..| |.|.. .| . | .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

E---KHSVVLQWERRAKIVADVARALAFLHGKCEPPIVHGDVKPSNVLLGADFGAKLADFGLAR
    |... ...    .. ...|.....|. |    ..| |.   |.|.. .. .| .||||||
HREDKQPLTMKD--LLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLAR
Kinase IRAK-Un_bx-1.AA LISK 116-266 28 6.5e-26 81.02 In-house 1-159 (296) Show / Hide 
Range on Protein: 116-266
Range on HMM: 1-159/296
Sequence Identity: 28% (46 aa)

KLGQGGFGSVFKGTLK-NGQHIAVKKLDT-----ASLQGEREFMNELSIMGSMASSPFVVGLIGFCAE-TKRKMLVYEFMANRSLQEVLFDEK-HSVVLQ
..|.|.||.|.|||..  || .|.|.. .          .. .  |. .| .. . |..|  .| | .  .. ..| |..    |.. |.|.. |...| 
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNL-RHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLP

WERRAKIVADVARALAFLHGKCEPPIVHGDVKPSNVLLG----ADFGAKLADFGLARVKTQES
|. | ||  |.|.....|| ..   |.| | |  |.|..     .. .|..|||.||. ..|.
WPQRVKIALDIACGMSYLHSMN---IIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCEN
Kinase IRAK-Un_bx-1.AA LRRK 111-260 21 1.8e-25 87.05 In-house 1-226 (351) Show / Hide 
Range on Protein: 111-260
Range on HMM: 1-226/351
Sequence Identity: 21% (50 aa)

FSDSHKLGQGGFG-SVFKGTLKN---------------------------GQHIAVKKLDTA----------------------------------SLQG
.    ..|.|||| .|.......                           .| .|.||...                                   ..  
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

EREFMNELSIMGSMASSPFVVGLIGFCAETKRKMLVYEFMANRSLQEVLFDEKHSV------VLQWERRAKIVADVARALAFLHGKCEPPIVHGDVKPSN
 ||| .|..|| ..   | .| |.|||   .  ..| |.. . .|...|...|..       .. |  . ||. ..|.....|| .. |||.| | |. |
FREFRHEVWIMSHL-NHPNIVSLKGFC--IHPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLH-SHNPPIIHRDLKSPN

VLL-----G-------ADFGAKLADFGLAR
.||     .       |.  ||.||||. |
ILLWSSPQNHSPNYPNAHVCAKIADFGISR
Kinase IRAK-Un_bx-1.AA RIPK 117-264 28 3.3e-24 79.39 In-house 1-161 (290) Show / Hide 
Range on Protein: 117-264
Range on HMM: 1-161/290
Sequence Identity: 28% (46 aa)

LGQGGFGSVFKGTLKNGQHIAVKKL------DTASLQGEREFMNELSIMGSMASSPFVVGLIGFCAETKR------KMLVYEFMANRSLQEVLFDEK--H
.| |||| ||| . .   . ..||       .|. .. ||. . |   .  ..   ..| . ||| . .         .| |.|.| || ..|  .    
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ

SVVLQWERRAKIVADVARALAFLHGKCEPPIVHGDVKPSNVLLGADFGAKLADFGLARVKTQ
   . |  |  ..  ....  .||..  ||| | | ||.|.|. ..| .|.||||||  ...
HHPDPWPLRCRMIHEISCGMCYLHSM-NPPIIHRDLKPENILVDNNFHVKIADFGLATWMMW
Kinase IRAK-Un_bx-1.AA MLK 111-260 22 1.2e-23 79.05 In-house 1-181 (291) Show / Hide 
Range on Protein: 111-260
Range on HMM: 1-181/291
Sequence Identity: 22% (41 aa)

FSDSHKLGQGGFGSVFKGTLKNGQ----HIAVKKLD----------TASLQGEREFMNELSIMGSMASSPFVVGLIGFCAET-KRKMLVYEFMANRSLQE
.  ....| |.||.|.||. .|       .|||. .          . . . |.|.. .|.|.     .| .. . | |... .   .| |.... || .
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECR-HLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

VLFDEK-----------HSVVLQWERRAKIVADVARALAFLHGKCEPPIVHGDVKPSNVLLGA------DFGAKLADFGLAR
|| ...            ..|   .  ...  ..||....|| .  .||.| | |..|.|. .      .  .| .|||..|
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSR
Kinase IRAK-Un_bx-1.AA TK-Unique 116-260 22 2.1e-22 74.16 In-house 6-181 (294) Show / Hide 
Range on Protein: 116-260
Range on HMM: 6-181/294
Sequence Identity: 22% (41 aa)

KLGQGGFGSVFKGTLKN-------GQHIAVKKLD-TASLQGEREFMNELSIMGSMASSPFVVGLIGFCAETK-RKMLVYEFMANRSLQEVLF--------
..|.| || |..|....        ...|||.|   |... ...|..|...| .    | .| ..| | ..  . |...|.... .||  |         
VIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRPAMRQ

---------------DEKHSVVLQWERRAKIVADVARALAFLHG--K-CEPPIVHGDVKPSNVLLGADFGAKLADFGLAR
               |..    .. .. . .  ..|.....|..  | .    ||.|.  .||||. |. .|..|||.||
HQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKI----VHRDLCARNVLLTEDKVCKICDFGMAR
Kinase IRAK-Un_bx-1.AA TyrKc 111-671 11 4.1e-15 21.66 SMART 1-280 (280) Show / Hide 
Range on Protein: 111-671
Range on HMM: 1-280/280
Sequence Identity: 11% (66 aa)

FSDSHKLGQGGFGSVFKGTLKNGQHIAVKKLDTASLQGEREFMNELSIMGSM-ASSPFVVGLIGFCAET-------KRKMLVYEFMANRSLQEVLFDEKH
 .  .||| | || |.|||.|  .  |||.|   .   ...||.|..|| .   . | .| |.| | .        .  |.| |.|.. .|.. | . ..
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

SVVLQWERRAKIVADVARALAFLHGKCEPPIVHGDVKPSNVLLGADFGAKLADFGLARVKTQE-SAAVDERERNDDFGKLSRGGAATPS--------SIG
   |...   ..  ..|.  ..|| |   ...| |    |.|.|... .| .||||.|  . . ..     |. |   | ...|. |.         .| 
K--LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG----ESKDYYRKKEHKGGKTMLPIRWMAPECI-

GGQDDDEEWSKLSQSAYGTEADTWS------------KISPSE-----IDCRSEISFDGTGQGQAGIKN----FLGRKKPWGQRKASASPSSGNGKNSNN
              . . |. | ||            .  ...     .. .  | .  .|      .|                               
------------NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS--------------------------

GSRDWWWKQESSGQQGGGGGEFSIREYIVDWVSCENRRGRSRTREWPWNAASSGTAGAAAAGTSSEGKNNVKKKKKQARSGSLEWWAECDDDDELAKRIK
                                                                                                    
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AEQKRKKNREWWSGEMQRGKEWWSGELTSNETNNNNRKGGRLFETWSRESLSGELTRRRRRERSRSHSRDWWSGDLVSRVSSTPSMRGTVCYVAPEYGGG
                                                                                                    
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GVLTEKSDVYSFGVLLLVVVSGRRPLQVVAAPLSEFERANLISWARHAAQAGRGLDLVDPLLAGAYSKEQATLFISLALLCLQRVPSLRPSMSDVVKIF
                                                                  . .  .   .. . | .. |. ||..|.....|
------------------------------------------------------------------FVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase IRAK-Un_bx-1.AA TKL 557-671 16 1e-12 42.13 In-house 232-364 (364) Show / Hide 
Range on Protein: 557-671
Range on HMM: 232-364/364
Sequence Identity: 16% (24 aa)

SMRGTVCYVAPEY----------------GGGGVLTEKSDVYSFGVLLLVVVSGRRPLQVVAAPLSEFERANLISWARH----AAQAGRGLDLVDPLLAG
. .|| .. |||                  .|.  .||.||||||..|  .....|           ..  . ...       . .......   |..  
TQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR----------PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPP

AYS--------KEQATLFISLALLCLQRVPSLRPSMSDVVKIF
  .        .   . ...|.  | .  |. |||.....|..
IWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAK-Un_bx-1.AA IRAK 552-597 45 1.6e-08 26.51 In-house 176-223 (317) Show / Hide 
Range on Protein: 552-597
Range on HMM: 176-223/317
Sequence Identity: 45% (22 aa)

VSSTPSMRGTVCYVAPEYGG--GGVLTEKSDVYSFGVLLLVVVSGRRP
.  |   |||  | .||.     | || |.||||||. || |..|.|.
CMMTSHVRGTTWYMPPEFIRDPQGQLTKKTDVYSFGIVLLEVLTGCRA
Kinase IRAK-Un_bx-1.AA MLK 556-588 38 1.5e-05 15.38 In-house 191-226 (291) Show / Hide 
Range on Protein: 556-588
Range on HMM: 191-226/291
Sequence Identity: 38% (14 aa)

PSMRGTVCYVAPEY---GGGGVLTEKSDVYSFGVLL
.|..||. . |||      ..  .||.||.|.||.|
MSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVL
Kinase IRAK-Un_bx-1.AA LRRK 550-588 31 1.6e-05 15.52 In-house 225-272 (351) Show / Hide 
Range on Protein: 550-588
Range on HMM: 225-272/351
Sequence Identity: 31% (15 aa)

SR----VSS--TPSMRGTVCYVAPEYGGGG---VLTEKSDVYSFGVLL
||    . .  .. . |.  ..|||  ...   . |||.|.||||..|
SRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMIL
Kinase IRAK-Un_bx-1.AA RIPK 574-597 41 2.5e-05 14.06 In-house 204-227 (290) Show / Hide 
Range on Protein: 574-597
Range on HMM: 204-227/290
Sequence Identity: 41% (10 aa)

VLTEKSDVYSFGVLLLVVVSGRRP
| |.|.|||||....  | ... |
VVTPKYDVYSFAIVMWEVLTQKHP
Kinase IRAK-Un_bx-1.AA TK-Unique 566-588 53 6.1e-05 13.12 In-house 204-229 (294) Show / Hide 
Range on Protein: 566-588
Range on HMM: 204-229/294
Sequence Identity: 53% (14 aa)

APEYGG--GGVL-TEKSDVYSFGVLL
|||.    .|.  |.||||.|||||.
APESLKCYHGMYHTTKSDVWSFGVLM
Kinase IRAK-Un_bx-1.AA TK 649-671 26 0.00019 9.98 In-house 464-486 (486) Show / Hide 
Range on Protein: 649-671
Range on HMM: 464-486/486
Sequence Identity: 26% (6 aa)

LALLCLQRVPSLRPSMSDVVKIF
| . | .. |. ||..|.... .
LMQQCWHYDPEDRPTFSQLHEQL
Kinase IRAK-Un_bx-1.AA TK-Unique 653-671 31 0.000743 9.32 In-house 276-294 (294) Show / Hide 
Range on Protein: 653-671
Range on HMM: 276-294/294
Sequence Identity: 31% (6 aa)

CLQRVPSLRPSMSDVVKIF
|.|..|. ||| .......
CWQWEPEERPSFRQIKHRL
Kinase IRAK-Un_bx-1.AA LRRK 652-673 40 0.001008 9.03 In-house 330-351 (351) Show / Hide 
Range on Protein: 652-673
Range on HMM: 330-351/351
Sequence Identity: 40% (9 aa)

LCLQRVPSLRPSMSDVVKIFSG
.| |  |  ||..|..||. | 
HCWQHDPKKRPHFSQIVKRLSQ
Kinase IRAK-Un_bx-1.AA Pkinase_Tyr 573-588 68 0.001133 13.06 Pfam 189-204 (270) Show / Hide 
Range on Protein: 573-588
Range on HMM: 189-204/270
Sequence Identity: 68% (11 aa)

GVLTEKSDVYSFGVLL
|. |.||||.|||||.
GKFTTKSDVWSFGVLM
Kinase IRAK-Un_bx-1.AA MLK 653-671 31 0.001393 8.45 In-house 273-291 (291) Show / Hide 
Range on Protein: 653-671
Range on HMM: 273-291/291
Sequence Identity: 31% (6 aa)

CLQRVPSLRPSMSDVVKIF
| .  |. |||.. .|...
CWNQDPHKRPSFRQIVQHL
Kinase IRAK-Un_bx-1.AA LISK 576-589 50 0.004631 5.56 In-house 217-230 (296) Show / Hide 
Range on Protein: 576-589
Range on HMM: 217-230/296
Sequence Identity: 50% (7 aa)

TEKSDVYSFGVLLL
.|..||.|||..|.
DESCDVFSFGIVLC
Kinase IRAK-Un_bx-1.AA Pkinase 553-599 33 0.070174 7.73 Pfam 167-213 (293) Show / Hide 
Range on Protein: 553-599
Range on HMM: 167-213/293
Sequence Identity: 33% (16 aa)

SSTPSMRGTVCYVAPEYGG-GGVLTEKSDVYSFGVLLLVVVSGRRPLQ
| . .  ||  |.|||    |   . |.|..|.|..|  ...|| | .
S-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFP
Kinase IRAK-Un_bx-1.AA LISK 646-671 30 0.212995 0.07 In-house 271-296 (296) Show / Hide 
Range on Protein: 646-671
Range on HMM: 271-296/296
Sequence Identity: 30% (8 aa)

FISLALLCLQRVPSLRPSMSDVVKIF
|. |.. |    |. ||| ...|...
FLDLCFDCCKYDPKNRPSFKEIVQWL
Kinase IRAK-Un_bx-1.AA Pkinase_Tyr 651-671 23 0.305076 4.83 Pfam 250-270 (270) Show / Hide 
Range on Protein: 651-671
Range on HMM: 250-270/270
Sequence Identity: 23% (5 aa)

LLCLQRVPSLRPSMSDVVKIF
..| .  |. ||..|... ..
KQCWHYDPEDRPTFSEIHEQL
Kinase IRAK-Un_bx-1.AA Pkinase 653-671 28 8.519288 0.36 Pfam 273-293 (293) Show / Hide 
Range on Protein: 653-671
Range on HMM: 273-293/293
Sequence Identity: 28% (6 aa)

CLQRVPSLRPSMSDVVKI--F
||.. |. ||.  ....   |
CLCKDPKKRPTAEQILQHPWF