Gene IRAK-Un_br-1 (S.moellendorffii)
IRAK-Un_br-1
Species: S.moellendorffii
Alias: IRAK-Un_br-1
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| IRAK-Un_br-1.AA | Protein | None | 319 | None | Fasta, JSON |
| IRAK-Un_br-1.NA | RNA | None | 960 | None | Fasta, JSON |
| IRAK-Un_br-1.kin_dom | Protein Kinase Domain | None | 110 | None | Fasta, JSON |
Protein domains of IRAK-Un_br-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | IRAK-Un_br-1.AA | TKL | 28-245 | 19 | 3.3e-24 | 84.09 | In-house | 116-364 (364) | Show / Hide |
Range on Protein: 28-245
Range on HMM: 116-364/364
Sequence Identity: 19% (54 aa)
VYEIQANGS-LDRLLYGRSRDRPPLDWATRVRIATDAARGLAFLHERSP-----TKLMYKDFRTFNVHVDKELR--------------ARLMGYGFTQRF
|.| .|| |..|. | |.|.| |.|||...|| . | .. . | . |. ||. .. . . .|. ...
VMEYCPGGSLLHYLH-----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFM
-----MNPSSLMVR----SKVLAERILTRCC-SLCLKVAAYAAPELLQRGAQ-------------SLPSPKSNVWSFGVVLLEILTGRQNRDEMFAVEEQ
|| .. ... .. . . . ..| ... . |||.|. . . |.|. |.|||.|| ||||... ...
SQSGNMNDTMTTMMESAEHQ-NNRKTTMTQCGTPR-----WMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR------PYYDY
DLVGWTAPYLANDKKLFLVVDPELKGMFP------------ARSVSLFAKLAAQCLQRDPAARPSMDQVVQSL
. . . . . . .|.| |. | ..||. .| . || .|||...... |
PYMPMIFQDP-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
|
|||||||||
| Kinase | IRAK-Un_br-1.AA | IRAK | 153-245 | 22 | 4.3e-11 | 35.7 | In-house | 202-317 (317) | Show / Hide |
Range on Protein: 153-245 Range on HMM: 202-317/317 Sequence Identity: 22% (27 aa) SPKSNVWSFGVVLLEILTGR-QNRDE--------MFAVEEQDLVG-----------------WTAPYLANDKKLFLVVDPELKGMFPARSVSLFAKLAAQ ..|. | |||.||||.|||. . .|. |. . | | || . . ..|. ..... | .. .. .| . TKKTDVYSFGIVLLEVLTGCRAVYDDRPEHYYLKDLCEEIMEEWGHLDSCQSTLWVGVATDAWAAPRRMQIYEKFID---HRMPPCPPNMEKEMCQCACC CLQRDPAARPSMDQVVQSL |. . . |..|..|.|.| CGHHRANRRCDMAWVMQQL |
|||||||||
| Kinase | IRAK-Un_br-1.AA | Pkinase | 138-245 | 18 | 4.6e-10 | 36.68 | Pfam | 177-293 (293) | Show / Hide |
Range on Protein: 138-245
Range on HMM: 177-293/293
Sequence Identity: 18% (26 aa)
YAAPELLQRGAQSLPSPKSNVWSFGVVLLEILTGRQNRDEMFAVEEQDLVGWTAPYLAN--------DKKLFLVVDPELKGMFPARSV------------
|.|||... .. .||. .||.|..| | |.|| |. ....... .|.|. .| .
YMAPEVIR--GGQYYGPKVDMWSCGCILYEMLCGR------------------PPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFH
-------SLFAKLAAQCLQRDPAARPSMDQVVQS--L
. . .. ||..||. ||. .|..|. .
WTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
|
|||||||||
| Kinase | IRAK-Un_br-1.AA | LRRK | 34-75 | 25 | 1e-09 | 30.55 | In-house | 139-185 (351) | Show / Hide |
Range on Protein: 34-75 Range on HMM: 139-185/351 Sequence Identity: 25% (12 aa) NGSLDRLLYGRSRDR-----PPLDWATRVRIATDAARGLAFLHERSP .|.|...| ...|. . ..| .. .||.. |.|...|| ..| HGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNP |
|||||||||
| Kinase | IRAK-Un_br-1.AA | IRAK | 15-75 | 31 | 2e-08 | 26.15 | In-house | 68-130 (317) | Show / Hide |
Range on Protein: 15-75 Range on HMM: 68-130/317 Sequence Identity: 31% (20 aa) ILGFSFTTDEKLVVYEIQANGSLDRLLYGRSRDRPP--LDWATRVRIATDAARGLAFLHERSP ..|... ... ||. .|||| | .. . || | | .|. |. .|.|. |||. .| LYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQCPPKPLSWHQRCSICWGTACGIQFLHQNHP |
|||||||||
| Kinase | IRAK-Un_br-1.AA | TK-Unique | 140-170 | 46 | 2e-08 | 25.29 | In-house | 204-234 (294) | Show / Hide |
Range on Protein: 140-170 Range on HMM: 204-234/294 Sequence Identity: 46% (15 aa) APELLQRGAQSLP-SPKSNVWSFGVVLLEILT ||| |.. . ..||.||||||.. ||.| APESLKCY-HGMYHTTKSDVWSFGVLMWEIFT |
|||||||||
| Kinase | IRAK-Un_br-1.AA | TK | 140-170 | 40 | 1.9e-07 | 20.22 | In-house | 353-389 (486) | Show / Hide |
Range on Protein: 140-170 Range on HMM: 353-389/486 Sequence Identity: 40% (15 aa) APELLQRGA------QSLPSPKSNVWSFGVVLLEILT ||| |. . ..|| ||||||.. ||.| APECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFT |
|||||||||
| S_TKc | IRAK-Un_br-1.AA | S_TKc | 1-250 | 13 | 2.3e-07 | -68.83 | SMART | 15-231 (231) | Show / Hide |
Range on Protein: 1-250 Range on HMM: 15-231/231 Sequence Identity: 13% (39 aa) VKEIVCLR------------------------DAHLSRILGFSFTTDEKLVVYEIQAN--GSLDRLLYGRSRDRPP--LDWATRVRIATDAARGLAFLHE |. . . .. ..... . |. .| | . |.| ... | | ... .. . ... ...|...|. VYKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHS RSPTKLMYKDFRTFNVHVDKELRARLMGYGFTQRFMNPSSLMVRSKVLAERILTRCCSLCLKVAAYAAPELLQRGAQSLPSP-KSNVWSFGVVLLEILTG . . .. | |. .|. . . |. .. . . | |||.| .. |. .||.|..| | |.| H---GIIHRDLKPENILLDE--HIKICDFGLARQL----------------------TTFCGTPWYMAPEVL------GYGKCKCDWWSCGCILYEMLCG RQ---NRDEMFAVEEQDLVGWTAPYLANDKKLFLVVDPELKGMFPARSVSLFAKLAAQCLQRDPAARPSMDQVVQ----SLEHVQA . . ..|| . | .. . .|||.||. ||. .. | | YPPFPQMQMMFKKIG--------------------------------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
|||||||||
| Kinase | IRAK-Un_br-1.AA | DRK | 220-247 | 35 | 3.2e-07 | 20.53 | In-house | 231-258 (258) | Show / Hide |
Range on Protein: 220-247 Range on HMM: 231-258/258 Sequence Identity: 35% (10 aa) FAKLAAQCLQRDPAARPSMDQVVQSLEH ...| |. || ||||..... || YIQLMNDCWNEDPQHRPSMQECLERLEA |
|||||||||
| Kinase | IRAK-Un_br-1.AA | Dicty4 | 220-247 | 36 | 4.5e-07 | 19.83 | In-house | 248-277 (277) | Show / Hide |
Range on Protein: 220-247 Range on HMM: 248-277/277 Sequence Identity: 36% (11 aa) FAKLAAQCLQRDPAARPSMDQVVQS--LEH ...| . |. || |||. ...| ||| WKHLIQWCWDHDPQHRPSFEEIIQRRILEH |
|||||||||
| TyrKc | IRAK-Un_br-1.AA | TyrKc | 1-245 | 14 | 4.9e-07 | -108.95 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 1-245 Range on HMM: 1-280/280 Sequence Identity: 14% (46 aa) VK-------------------------------------EIVCLRDA-----HLSRILGFSFTT-------DEKLVVYEIQANGSLDRLLYGRSRDRPPL .. |. .. .. |..| . . ..| | ..|.|. | . .. | ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK---L DWATRVRIATDAARGLAFLHERSPTKLMYKDFRTFNVHVDKELRARLMGYGFTQRFMNPSSLMVR------SKVLAER--------ILTR----CCS--L ... . .....|.| ..||.. .. | . |. |.... |. |. . . . .. | CMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENH-------------------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTML CLKVAAYAAPELLQRGAQSLPSPKSNVWSFGVVLLEILT-GRQNRDEM----FAVEEQDLVGWTAPYLANDKKLFLVVDPELKGM-FPARSVSLFAKLAA .. ||| . . ..|| ||||||.. ||.| | | .| .| |. . . . ... | | . . .. PIR---WMAPECI---NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQE------VIEYVKQGYRMPQPPNDY-P-MSF-VCCPDEMYQIMK QCLQRDPAARPSMDQVVQSL || ..||. ||.. .... . QCWHEDPEDRPTFSEIHECF |
|||||||||
| Kinase | IRAK-Un_br-1.AA | MLK | 220-245 | 50 | 5.1e-07 | 20.54 | In-house | 266-291 (291) | Show / Hide |
Range on Protein: 220-245 Range on HMM: 266-291/291 Sequence Identity: 50% (13 aa) FAKLAAQCLQRDPAARPSMDQVVQSL ..|| || . ||. |||..|.|| | WKKLMKQCWNQDPHKRPSFRQIVQHL |
|||||||||
| Kinase | IRAK-Un_br-1.AA | TK | 217-245 | 22 | 3e-06 | 16.17 | In-house | 447-486 (486) | Show / Hide |
Range on Protein: 217-245 Range on HMM: 447-486/486 Sequence Identity: 22% (9 aa) V-----------SLFAKLAAQCLQRDPAARPSMDQVVQSL . ... | || ..||. ||...|... | MRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL |
|||||||||
| Kinase | IRAK-Un_br-1.AA | MLK | 136-172 | 45 | 4e-06 | 17.51 | In-house | 197-233 (291) | Show / Hide |
Range on Protein: 136-172 Range on HMM: 197-233/291 Sequence Identity: 45% (17 aa) AAYAAPELLQRGAQSLPSPKSNVWSFGVVLLEILTGR .|. ||| .|. . | |. |||.|||| |.||.. YAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTRE |
|||||||||
| Kinase | IRAK-Un_br-1.AA | TK | 7-73 | 8 | 1.2e-05 | 14.09 | In-house | 100-253 (486) | Show / Hide |
Range on Protein: 7-73
Range on HMM: 100-253/486
Sequence Identity: 8% (13 aa)
LRDAHLSRILGFSFTTDEK------------LVVYEIQANGS----LDRLLYGRSRDRPP----------------------------------------
.. .. |..| .. ..| ..| | ..|. |. | ..... .
GHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQD
--------------------------------LDWATRVRIATDAARGLAFLHER
|. .... .. ..|.|...||..
YDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSK
|
|||||||||
| Kinase | IRAK-Un_br-1.AA | UTK | 26-73 | 32 | 1.3e-05 | 15.19 | In-house | 86-137 (296) | Show / Hide |
Range on Protein: 26-73 Range on HMM: 86-137/296 Sequence Identity: 32% (17 aa) LVVYEIQANGSLDRLLYGRSRDRP-PLDWAT---RVRIATDAARGLAFLHER ..|.| ..||.|. .| ... | . .| | |. | | |||...||.. MIVTEYMENGDLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSC |
|||||||||
| Kinase | IRAK-Un_br-1.AA | Dicty4 | 50-75 | 44 | 1.4e-05 | 14.78 | In-house | 105-133 (277) | Show / Hide |
Range on Protein: 50-75 Range on HMM: 105-133/277 Sequence Identity: 44% (13 aa) PLDWATRVR---IATDAARGLAFLHERSP .||| .. | .| |||||.. ||.. | KLDWPLIKRAMRMAFDAARGMNWLHCCNP |
|||||||||
| Kinase | IRAK-Un_br-1.AA | UTK | 140-171 | 50 | 2.9e-05 | 13.98 | In-house | 207-236 (296) | Show / Hide |
Range on Protein: 140-171 Range on HMM: 207-236/296 Sequence Identity: 50% (16 aa) APELLQRGAQSLPSPKSNVWSFGVVLLEILTG ||| | .. .. || |||||||. ||.|. APEALTHHT--RFTTKSDVWSFGVVCWEIWTW |
|||||||||
| Kinase | IRAK-Un_br-1.AA | TKL-Unique | 136-173 | 42 | 4.3e-05 | 14.12 | In-house | 190-226 (290) | Show / Hide |
Range on Protein: 136-173 Range on HMM: 190-226/290 Sequence Identity: 42% (16 aa) AAYAAPELLQRGAQSLPSPKSNVWSFGVVLLEILTGRQ . ..|||.| . .. | || |.|||.|| ||.|. . FRWMAPEVLRMNF-CQYSEKSDVYSFGIVLWEIATRKI |
|||||||||
| Kinase | IRAK-Un_br-1.AA | DRK | 51-75 | 32 | 0.000112 | 11.81 | In-house | 95-119 (258) | Show / Hide |
Range on Protein: 51-75 Range on HMM: 95-119/258 Sequence Identity: 32% (8 aa) LDWATRVRIATDAARGLAFLHERSP .|| . ... |.|.|. .|| . | MDWPLMKQMMFDCAKGMIYLHCCNP |
|||||||||
| Kinase | IRAK-Un_br-1.AA | TKL-Unique | 226-245 | 45 | 0.000113 | 12.61 | In-house | 271-290 (290) | Show / Hide |
Range on Protein: 226-245 Range on HMM: 271-290/290 Sequence Identity: 45% (9 aa) QCLQRDPAARPSMDQVVQSL || .|| ||| |... .| QCWHHDPSQRPSFDEIIHRL |
|||||||||
| Kinase | IRAK-Un_br-1.AA | TKL-Unique | 50-103 | 25 | 0.000187 | 11.83 | In-house | 106-163 (290) | Show / Hide |
Range on Protein: 50-103 Range on HMM: 106-163/290 Sequence Identity: 25% (15 aa) PLDWATRVRIATDAARGLAFLHERSPTKLMYKDFRTFNVHVDKE-----LRARLMGYGF .|... ||..| |.|.|. .|| ..|. . | .. |. || . ..... . |. KLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGL |
|||||||||
| Kinase | IRAK-Un_br-1.AA | TK-Unique | 226-245 | 40 | 0.000305 | 10.67 | In-house | 275-294 (294) | Show / Hide |
Range on Protein: 226-245 Range on HMM: 275-294/294 Sequence Identity: 40% (8 aa) QCLQRDPAARPSMDQVVQSL .|.|..| ||| .|... | SCWQWEPEERPSFRQIKHRL |
|||||||||
| Kinase | IRAK-Un_br-1.AA | MLK | 33-75 | 28 | 0.000446 | 10.19 | In-house | 93-145 (291) | Show / Hide |
Range on Protein: 33-75 Range on HMM: 93-145/291 Sequence Identity: 28% (15 aa) ANGSLDRLLYG-RSRDRP---------PLDWATRVRIATDAARGLAFLHERSP ..||| ..|.| || . | . ...|.. |||...||. | EGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAP |
|||||||||
| Kinase | IRAK-Un_br-1.AA | LRRK | 226-247 | 40 | 0.001001 | 9.04 | In-house | 330-351 (351) | Show / Hide |
Range on Protein: 226-247 Range on HMM: 330-351/351 Sequence Identity: 40% (9 aa) QCLQRDPAARPSMDQVVQSLEH .| | || ||.. |.|. |. HCWQHDPKKRPHFSQIVKRLSQ |
|||||||||
| Kinase | IRAK-Un_br-1.AA | UTK | 222-245 | 33 | 0.001054 | 8.55 | In-house | 273-296 (296) | Show / Hide |
Range on Protein: 222-245 Range on HMM: 273-296/296 Sequence Identity: 33% (8 aa) KLAAQCLQRDPAARPSMDQVVQSL .| .| . ||. ||.....|| . RLMHRCWHYDPQERPDFEDLVQQM |
|||||||||
| Kinase | IRAK-Un_br-1.AA | Pkinase_Tyr | 226-245 | 35 | 0.001592 | 12.56 | Pfam | 251-270 (270) | Show / Hide |
Range on Protein: 226-245 Range on HMM: 251-270/270 Sequence Identity: 35% (7 aa) QCLQRDPAARPSMDQVVQSL || . ||. ||.. .... | QCWHYDPEDRPTFSEIHEQL |
|||||||||
| Kinase | IRAK-Un_br-1.AA | Pkinase_Tyr | 33-73 | 21 | 0.021376 | 8.74 | Pfam | 90-130 (270) | Show / Hide |
Range on Protein: 33-73 Range on HMM: 90-130/270 Sequence Identity: 21% (9 aa) ANGSLDRLLYGRSRDRPPLDWATRVRIATDAARGLAFLHER ..|.|. | .. |..||. . . .... |.|...|... PHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESK |
|||||||||
| Kinase | IRAK-Un_br-1.AA | Pkinase_Tyr | 158-173 | 64 | 0.026571 | 8.42 | Pfam | 197-213 (270) | Show / Hide |
Range on Protein: 158-173 Range on HMM: 197-213/270 Sequence Identity: 64% (11 aa) VWSFGVVLLEILT-GRQ ||||||.. ||.| |.| VWSFGVLMWEIFTYGEQ |
|||||||||
| Kinase | IRAK-Un_br-1.AA | Dicty4 | 155-171 | 64 | 0.068482 | 2.29 | In-house | 197-213 (277) | Show / Hide |
Range on Protein: 155-171 Range on HMM: 197-213/277 Sequence Identity: 64% (11 aa) KSNVWSFGVVLLEILTG |. | ||| || ||||. KADVYSFGIVLWEILTR |
|||||||||
| Kinase | IRAK-Un_br-1.AA | DRK | 155-170 | 50 | 0.188594 | 0.72 | In-house | 182-197 (258) | Show / Hide |
Range on Protein: 155-170 Range on HMM: 182-197/258 Sequence Identity: 50% (8 aa) KSNVWSFGVVLLEILT | |.||..|| |..| KADVYSFAIVLWECVT |
|||||||||
| Kinase | IRAK-Un_br-1.AA | Pkinase | 34-74 | 12 | 3.292922 | 1.82 | Pfam | 84-128 (293) | Show / Hide |
Range on Protein: 34-74 Range on HMM: 84-128/293 Sequence Identity: 12% (6 aa) NG----SLDRLLYGRSRDRPPL--DWATRVRIATDAARGLAFLHERS .| .| ... . ... .. .. . .... .|||...|... GGLYVMDLFDYIST--WRHGCFYFSEWECKFYMYQILRGLEYCHSMG |
|||||||||