Gene IRAK-Un_av-2 (S.moellendorffii)
IRAK-Un_av-2
Species: S.moellendorffii
Alias: IRAK-Un_av-2
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| IRAK-Un_av-2.AA | Protein | None | 475 | None | Fasta, JSON |
| IRAK-Un_av-2.NA | RNA | None | 1428 | None | Fasta, JSON |
| IRAK-Un_av-2.kin_dom | Protein Kinase Domain | None | 258 | None | Fasta, JSON |
Protein domains of IRAK-Un_av-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | IRAK-Un_av-2.AA | TKL | 38-135 | 20 | 1.7e-13 | 44.96 | In-house | 9-147 (364) | Show / Hide |
Range on Protein: 38-135
Range on HMM: 9-147/364
Sequence Identity: 20% (30 aa)
VYKGRLDQ---------NRWIAVKKFPKTA-----------------------WPDARQFMDEAFGVGQV----RHERLVNLIGCCCEGDE---------
||||.. . ....|||||... .|.|..|... . . ||. .| ..|.||...
VYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVG
----RLLVAEYMPNDT-LTKHLFHWEKQPMQWSMRLRVALYIAQALEH
.| ||.|. . | .. |. |.| || ||.....
PWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNY
|
|||||||||
| Kinase | IRAK-Un_av-2.AA | TyrKc | 37-295 | 15 | 4.5e-11 | -43.6 | SMART | 14-280 (280) | Show / Hide |
Range on Protein: 37-295 Range on HMM: 14-280/280 Sequence Identity: 15% (49 aa) HVYKGRLDQNRWIAVKKFPKTAWPDARQFMDEAFGVGQV--RHERLVNLIGCCCEG-------DERLLVAEYMPNDTLTKHL-FHWEKQPMQWSMRLRVA ||||... . |||. . | . ||.|| .. .|. .|.|.|.| .. . ..| ||||. | ..| | .| ... | . EVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK--LCMKDLLSFC LYIAQALEHCSNNNRRLYHDLNAYRVLFDQVLFNPFRSLLVYALTAAV-----------LQDGD-PRLSCFGLMKNSRDG-------KSYS------TN- . ||. |. . . . . .. . | |||... |. . |. .. WQIACGMEYLHSK---------------------------------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKT ---LAYTPPEYLRTGRVTPESVIYSYGTVLLDLLSG-----KH-----IPPSHALDLIRGKNILMLMDSYLEGQFSND-----DGTELVRLASRCLQYEP . ..|| ...|. |..| ..|.| .. ... ....... ... . .. ..... .|. .. ..| ...| MLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY------PMSFVCCPDEMYQIMKQCWHEDP RERPTAKMLVQAL .||| . ... . EDRPTFSEIHECF |
|||||||||
| Kinase | IRAK-Un_av-2.AA | TKL | 200-295 | 17 | 1.2e-10 | 34.57 | In-house | 236-364 (364) | Show / Hide |
Range on Protein: 200-295 Range on HMM: 236-364/364 Sequence Identity: 17% (23 aa) NLAYTPPEYLRTGRVTPESV----------------IYSYGTVLLDLLSGKHIPPSHALDLIRGK-------NILMLMDSYLEGQFS------------N .... .|| || ..| | .||.| || .|.... | . .. . . . | | | . TPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR--PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCP DDGTELVRLASRCLQYEPRERPTAKMLVQAL | ... .|. .| ...|..||... ... | DCPPSMKKLMQDCWDHDPEKRPSFQEILKRL |
|||||||||
| S_TKc | IRAK-Un_av-2.AA | S_TKc | 24-296 | 17 | 5e-10 | -29.86 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 24-296 Range on HMM: 1-231/231 Sequence Identity: 17% (50 aa) DYIVSESGDKAPNHVYKGRLDQ-NRWIAVKKFPKTAWPDARQFMDEAFGVGQVRHERLVNLIGCCCEGDERLLVAEYMPN--DTLTKHLFHWEKQP---- |. . | | |||.| .| |.|. . .... | . .|. .|.|.... . |. .| ||... .| ... . ... YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP MQWSMRLRVALYIAQALEHCSNNNRRLYHDLNAYRVLFDQVLFNPFRSLLVYA---LTAAVLQDGDPRLSCFGLMKNSRDGKSYSTNLAYTPPEYLRTGR . . ... |..|||.| .. . .. || .|.|. . . | . . ... . | .|| | FPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--------HIKICDFGLARQL--------------------TTFCGTPWYMAPEVL---G VTP-ESVIYSYGTVLLDLLSGKHIPPSHALDLIRGKNILMLMDSYLEGQFSNDDGTELVRLASRCLQYEPRERPTAKMLVQ--------ALL .. .. ..| | .| .|.|. | .. |... . |. . ..|||..|..|||| . | . YGKCKCDWWSCGCILYEMLCGYPPFP----------QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
|||||||||
| Kinase | IRAK-Un_av-2.AA | TK-Unique | 76-109 | 31 | 2e-07 | 21.78 | In-house | 62-96 (294) | Show / Hide |
Range on Protein: 76-109 Range on HMM: 62-96/294 Sequence Identity: 31% (11 aa) RHERLVNLIGCCCEGD-ERLLVAEYMPNDTLTKHL .|. .|...|||.. | ... ||.|. .| ..| DHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYL |
|||||||||
| Kinase | IRAK-Un_av-2.AA | Pkinase_Tyr | 37-102 | 30 | 3.6e-07 | 24.92 | Pfam | 14-91 (270) | Show / Hide |
Range on Protein: 37-102 Range on HMM: 14-91/270 Sequence Identity: 30% (24 aa) HVYKGRLD-----QNRWIAVKKFPKTAWPDA---RQFMDEAFGVGQV-RHERLVNLIGCCC-EGDE--RLLVAEYMPN .||||... .. |||. . .| ... . || || | .|. .|.|.|.| .|. ..| ||||. EVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPH |
|||||||||
| Kinase | IRAK-Un_av-2.AA | Frk | 25-127 | 22 | 1e-06 | 18.55 | In-house | 2-103 (260) | Show / Hide |
Range on Protein: 25-127 Range on HMM: 2-103/260 Sequence Identity: 22% (23 aa) YIVSESGDKAPNHVYKGRLDQNRWIAVKKFPKTAWPDARQFMDEAFGVGQVRHERLVNLIGCCCEGDERLLVAEYMPNDTLTKHLFHWEKQPMQWSMRLR .. . | |. |. ... .|||. |. | . |. || . ..|| .|..| | . ....| | ...| ..| ... | |. QLIRRLGSGQFGEVWEGLWNNTTPVAVKTL-KPGTMDPNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQCQMQQL VAL | . VDM |
|||||||||
| Kinase | IRAK-Un_av-2.AA | UTK | 267-295 | 41 | 1e-06 | 19.03 | In-house | 268-296 (296) | Show / Hide |
Range on Protein: 267-295 Range on HMM: 268-296/296 Sequence Identity: 41% (12 aa) GTELVRLASRCLQYEPRERPTAKMLVQAL . .. || || .|.|.|||... |||.. PHPVYRLMHRCWHYDPQERPDFEDLVQQM |
|||||||||
| Kinase | IRAK-Un_av-2.AA | IRAK | 201-233 | 42 | 2e-06 | 19.08 | In-house | 186-220 (317) | Show / Hide |
Range on Protein: 201-233 Range on HMM: 186-220/317 Sequence Identity: 42% (15 aa) LAYTPPEYLR--TGRVTPESVIYSYGTVLLDLLSG ..| |||..| .|. |. . .|| | ||| .|.| TWYMPPEFIRDPQGQLTKKTDVYSFGIVLLEVLTG |
|||||||||
| Kinase | IRAK-Un_av-2.AA | TK | 38-102 | 18 | 6e-06 | 15.06 | In-house | 18-139 (486) | Show / Hide |
Range on Protein: 38-102
Range on HMM: 18-139/486
Sequence Identity: 18% (22 aa)
VYKGRLDQNR--------------------------WIAVKKFPKTAWPDARQFMD--------------EAFGVGQVR-----HERLVNLIGCCCEGDE
||||.. . . ||| ... ....|.| || . . |. .|.|.|.|..|..
VYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEP
------------RLLVAEYMPN
..| ||||.
KPCFEVVVHQEPWMIVMEYMPH
|
|||||||||
| Kinase | IRAK-Un_av-2.AA | Pkinase | 203-295 | 18 | 6e-06 | 22.1 | Pfam | 177-293 (293) | Show / Hide |
Range on Protein: 203-295 Range on HMM: 177-293/293 Sequence Identity: 18% (22 aa) YTPPEYLR-TGRVTPESVIYSYGTVLLDLLSGKHIPPSHALDLIRGKNILMLMDSYLEGQFSNDDG-----------------------TELVRLASRCL | .|| .| .|.. ..|.| .| .|.|. . |.| . .. . . ... ...... | |. . ..|| YMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHC-WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCL QYEPRERPTAKMLVQA--L .. | .||||. ..| . CKDPKKRPTAEQILQHPWF |
|||||||||
| Kinase | IRAK-Un_av-2.AA | Pkinase | 75-136 | 19 | 8e-06 | 21.74 | Pfam | 57-124 (293) | Show / Hide |
Range on Protein: 75-136 Range on HMM: 57-124/293 Sequence Identity: 19% (13 aa) VRHERLVNLIGCCCEGDERLLVAEYMPND----TLTKHLFHWEKQPM--QWSMRLRVALYIAQALEHC ..|. | |.... ..|. .| ||.... | .. |.. .. .. .... |...||.| LNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYC |
|||||||||
| Kinase | IRAK-Un_av-2.AA | TK | 268-295 | 35 | 8e-06 | 14.73 | In-house | 459-486 (486) | Show / Hide |
Range on Protein: 268-295 Range on HMM: 459-486/486 Sequence Identity: 35% (10 aa) TELVRLASRCLQYEPRERPTAKMLVQAL .|. .| .| .|.|..||| . |...| EEYYDLMQQCWHYDPEDRPTFSQLHEQL |
|||||||||
| Kinase | IRAK-Un_av-2.AA | Abl | 64-140 | 22 | 1.4e-05 | 14.08 | In-house | 41-117 (252) | Show / Hide |
Range on Protein: 64-140 Range on HMM: 41-117/252 Sequence Identity: 22% (17 aa) QFMDEAFGVGQVRHERLVNLIGCCCEGDERLLVAEYMPNDTLTKHLFHWEKQPMQWSMRLRVALYIAQALEHCSNNN .|. || . ...|. || |.| | .. |.|.. | .| . ... .. . | .| || ... ... EFLKEAAIMKEMKHPNLVQLLGVCTREPPFYIITEFMCYGNLLDYLRECDREELPAVVLLYMATQIASGMSYLEKRH |
|||||||||
| Kinase | IRAK-Un_av-2.AA | EGFR | 49-109 | 30 | 1.6e-05 | 14.12 | In-house | 31-91 (258) | Show / Hide |
Range on Protein: 49-109 Range on HMM: 31-91/258 Sequence Identity: 30% (19 aa) IAVKKF-PKTAWPDARQFMDEAFGVGQVRHERLVNLIGCCCEGDERLLVAEYMPNDTLTKHL .|.| . .| . ..||| .. |.|. || |.| | . . || ||| | .. VAIKVLREQTGPKANEEMLDEAYVMASVDHPHLVRLLGVCMHSQ-MQLVTQYMPYGCLLDYV |
|||||||||
| Kinase | IRAK-Un_av-2.AA | Fer | 261-296 | 29 | 2.9e-05 | 13.99 | In-house | 247-283 (283) | Show / Hide |
Range on Protein: 261-296 Range on HMM: 247-283/283 Sequence Identity: 29% (11 aa) QFSNDDGTELVRLAS-RCLQYEPRERPTAKMLVQALL .. | . .|.... .| |..| .|||.| ..| | PMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK |
|||||||||
| Kinase | IRAK-Un_av-2.AA | LRRK | 95-135 | 27 | 0.000232 | 11.32 | In-house | 132-179 (351) | Show / Hide |
Range on Protein: 95-135 Range on HMM: 132-179/351 Sequence Identity: 27% (13 aa) LVAEYMPNDTLTKHLFHWEKQP-------MQWSMRLRVALYIAQALEH .| ||.|. .| ..|.. .. . . |...|..|| || ..|. MVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEY |
|||||||||
| Kinase | IRAK-Un_av-2.AA | UTK | 61-135 | 26 | 0.00133 | 8.2 | In-house | 46-133 (296) | Show / Hide |
Range on Protein: 61-135 Range on HMM: 46-133/296 Sequence Identity: 26% (23 aa) DAR---QFMDEAF---GVGQVR-HERLVNLIGCCCEGDERLLVAEYMPNDTLTKHLFHWEKQPM---QWSM---RLRVALYIAQALEH . . .|| || .|.. |. ...|.| |. . ..| |||.| | . | . ..|. | || |. || .... EPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQY |
|||||||||
| Kinase | IRAK-Un_av-2.AA | Pkinase_Tyr | 269-295 | 33 | 0.004506 | 11.03 | Pfam | 244-270 (270) | Show / Hide |
Range on Protein: 269-295 Range on HMM: 244-270/270 Sequence Identity: 33% (9 aa) ELVRLASRCLQYEPRERPTAKMLVQAL |. .| .| .|.| .||| . ... | EIYDLMKQCWHYDPEDRPTFSEIHEQL |
|||||||||
| Kinase | IRAK-Un_av-2.AA | TK-Unique | 275-295 | 38 | 0.011281 | 5.19 | In-house | 274-294 (294) | Show / Hide |
Range on Protein: 275-295 Range on HMM: 274-294/294 Sequence Identity: 38% (8 aa) SRCLQYEPRERPTAKMLVQAL ..|.|.|| |||. ... | KSCWQWEPEERPSFRQIKHRL |
|||||||||
| Kinase | IRAK-Un_av-2.AA | LRRK | 267-297 | 25 | 0.022508 | 4.19 | In-house | 321-351 (351) | Show / Hide |
Range on Protein: 267-297 Range on HMM: 321-351/351 Sequence Identity: 25% (8 aa) GTELVRLASRCLQYEPRERPTAKMLVQALLP .... | | | .|..||.. |. | WHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ |
|||||||||
| Kinase | IRAK-Un_av-2.AA | Fer | 185-224 | 25 | 0.039006 | 3.2 | In-house | 158-205 (283) | Show / Hide |
Range on Protein: 185-224 Range on HMM: 158-205/283 Sequence Identity: 25% (12 aa) FGLMKN-SRDGKSYS-------TNLAYTPPEYLRTGRVTPESVIYSYG ||. .. |..|..|. . ...|| ..|| .|.. ..|.| FGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTGIYSPKTDVWSFG |
|||||||||
| Kinase | IRAK-Un_av-2.AA | IRAK | 38-102 | 28 | 0.04423 | 3.37 | In-house | 15-87 (317) | Show / Hide |
Range on Protein: 38-102 Range on HMM: 15-87/317 Sequence Identity: 28% (21 aa) VYKGRLDQNR-WIAVKKFPKTAWPDARQFMDEAFG-------VGQVRHERLVNLIGCCCEGDERLLVAEYMPN ||.|..... ||||. ..| . . . . ||. .| | | | |... || .|||| VYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPN |
|||||||||
| Kinase | IRAK-Un_av-2.AA | LRRK | 220-237 | 44 | 0.3248 | 0.03 | In-house | 265-282 (351) | Show / Hide |
Range on Protein: 220-237 Range on HMM: 265-282/351 Sequence Identity: 44% (8 aa) IYSYGTVLLDLLSGKHIP .||.| .| .||...|.| CYSFGMILWELLTRQHHP |
|||||||||