Gene IRAK-Un_bx-2 (S.moellendorffii)

IRAK-Un_bx-2

Species: S.moellendorffii
Alias: IRAK-Un_bx-2
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
IRAK-Un_bx-2.AA Protein None 709 None Fasta, JSON
IRAK-Un_bx-2.NA RNA None 2130 None Fasta, JSON
IRAK-Un_bx-2.kin_dom Protein Kinase Domain None 488 None Fasta, JSON

Protein domain

Protein domains of IRAK-Un_bx-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IRAK-Un_bx-2.AA TKL 117-266 22 1.6e-37 130.99 In-house 1-208 (364) Show / Hide 
Range on Protein: 117-266
Range on HMM: 1-208/364
Sequence Identity: 22% (49 aa)

LGQGGFGSVFKGTLKN---------GQHIAVKKLDTASLQG--------------------------EREFMNELSIMGSMASSPFVVGLIGFCADSKR-
.|.|||| |.||....         |. .||||. . . .                           .|.| .|   | |. . | .| ..|.| ...  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------KMLVYEFMANRSLQEILFDEKHSVVLQWERRAKIVADVARALAFLHG------KCEPPIVHGDVKPSNVLLGADFG------------
             ..|.|.. . || ..|          |..| ... |.||....||       .  |||.| | |..|.|.  ..             
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCT-KPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD

--AKLADFGLARVKTQES
  .|..||||.|...|..
WCCKICDFGLSRFMSQSG
Kinase IRAK-Un_bx-2.AA TKL-Unique 113-587 12 1.4e-32 112.23 In-house 1-218 (290) Show / Hide 
Range on Protein: 113-587
Range on HMM: 1-218/290
Sequence Identity: 12% (63 aa)

DSHKLGQGGFGSVFKGTLKNGQHIAVKKLDT---ASLQGEREFMNELSIMGSMASSPFVVGLIGFCA----DSKRKMLVYEFMANRSLQEILFD------
.. |.|.||.|.|.||.  .|  .|.|..      |.. ..|| ||...|     .|..| ..|.|.    . ..  .| |..   || . | .      
FWNKIGEGGYGQVYKGKW-RGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

-EKHSVVLQWERRAKIVADVARALAFLHGKCEPPIVHGDVKPSNVLLGAD-----FGAKLADFGLARVKTQESAAVDERERNDDFGKVSRGGAATPSSIG
  . .  | ...| |.. |.|... .||  ||||| |.| |.||.|.  .     . .|..||||.........    .  .                  
NNNNNCKLNMQQRVKMAIDIAQGMYYLHH-CEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTR----------------

GGQDDDEEWSKLSQSAYGTEADTWSKISPSEIDCRSEISFDGTGQGQAGIKNFLGRKKPWGQRKASASPSSGNGKNTNNGSRDWWWKQESSGQQGGGGGE
                                                                                                    
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FSIREYIVDWVSCENRRGRSRTREWPWNAASSGTAGAAAAGTSSEGKNNVKKKKKQARSGSLEWWAECDDDDELAKRIKAEQKRKKNREWWSGEMQRGKE
                                                                                                    
----------------------------------------------------------------------------------------------------

WWSGELTSNETNNNRKGGRLFETWSRESLSGELTRRRRRERSRSHSRDWWSGDLVSRVSSTPSMRGTVCYVAPEYGGG--GVLTEKSDVYSFGVLL
                                                             ..  |.  ..|||   .     .|||||||||. |
------------------------------------------------------------NQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVL
Kinase IRAK-Un_bx-2.AA IRAK 111-260 32 3e-32 111.64 In-house 1-161 (317) Show / Hide 
Range on Protein: 111-260
Range on HMM: 1-161/317
Sequence Identity: 32% (53 aa)

FSDSHKLGQGGFGSVFKGTLKNGQ-HIAVKKLDTASLQGEREFMNELSI----MGSMASS--PFVVGLIGFCADSKRKMLVYEFMANRSLQEILFDEKHS
|. ....|.|||| |..| .||     |||||       . | . ..      . ....   | .| | |.|...    |||..|.| ||.  |   . .
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

VV---LQWERRAKIVADVARALAFLHGKC-EPPIVHGDVKPSNVLLGADFGAKLADFGLAR
.    | | .|..|    |... ||| .    || |||.|..|.|| ..| .|..||||.|
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHR
Pkinase IRAK-Un_bx-2.AA Pkinase 111-272 20 1.6e-31 112.55 Pfam 1-171 (293) Show / Hide 
Range on Protein: 111-272
Range on HMM: 1-171/293
Sequence Identity: 20% (37 aa)

FSDSHKLGQGGFGSVFKGTLKNGQH-IAVKKLDTASLQGEREFMN-----ELSIMGSMASSPFVVGLIGFCADSKRKMLVYEFMANR----SLQEILF--
.    |.|.|.||.|.|.. |. ..  |||...    . . . ..     |..|| .. ..|..| |.... |...  .| |.. .     .| ...   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW

DEKHSVVLQWERRAKIVADVARALAFLHGKCEPPIVHGDVKPSNVLLGADFGA----KLADFGLARVK-TQESAAVDER
...    ....   ...  ..|.|...| .    |.| |.||.|.|.  .       |..|||||... .  .   . .
RHGCFY-FSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTF
Kinase IRAK-Un_bx-2.AA CAMK 116-594 8 1.2e-28 88.8 In-house 1-331 (425) Show / Hide 
Range on Protein: 116-594
Range on HMM: 1-331/425
Sequence Identity: 8% (54 aa)

KLGQGGFGSVFKGTLK-NG------------QHIAVKKLDTASLQ----------------------------GEREFMNELSIMGSM------ASSPFV
.||.|.|| |.... | ..            |. |.| .|.  |.                             ......|..|| ..       . | .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VGLIGFCAD-------------------SKRKMLVY---EFMANR----SLQEILFDEKH------------SVVLQWERRAKIVADVARALAFLHGKCE
. |. .  |                    |.  .|    |.. .      | . . . ..            .  .. .  ....  .. |....| .  
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN-

PPIVHGDVKPSNVLLGADF----------------G-AKLADFGLARVKTQES---------------AAVDERERNDDFGKVSRGGAATPSSIGGGQDD
  ||| | || |.||  ..                .  |..|||.|..... .               . .                             
--IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQ-W-----------------------------

DEEWSKLSQSAYGTEADTWSKISPSEIDCRSEISFDGTGQGQAGIKNFLGRKKPWGQRKASASPSSGNGKNTNNGSRDWWWKQESSGQQGGGGGEFSIRE
                                                                                                    
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YIVDWVSCENRRGRSRTREWPWNAASSGTAGAAAAGTSSEGKNNVKKKKKQARSGSLEWWAECDDDDELAKRIKAEQKRKKNREWWSGEMQRGKEWWSGE
                                                                                                    
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LTSNETNNNRKGGRLFETWSRESLSGELTRRRRRERSRSHSRDWWSGDLVSRVSSTP-------SMRGTVCYVA-PEYGGG--------------GVLTE
                                                      .||        . || .|.| ||   |                 ..
------------------------------------------------------TTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGP

KSDVYSFGVLLLVVVSGR
|.|. | ||.| . ..|.
KCDMWSCGVILYIMLCGY
Kinase IRAK-Un_bx-2.AA S_TKc 111-670 10 2e-28 101.67 SMART 1-231 (231) Show / Hide 
Range on Protein: 111-670
Range on HMM: 1-231/231
Sequence Identity: 10% (60 aa)

FSDSHKLGQGGFGSVFKGTLKN-GQHIAVKKLDTASLQGEREFMNELSIMGSMASSPFVVGLIGFCADSKRKMLVYEFMAN--RSLQEILFDEKHS---V
.    |.|.|.||.|.|.. |. |.. |.|...       . ...|..|. .    |..| |.... | ..  .| |.. .   .| ... . ..    .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

VLQWERRAKIVADVARALAFLHGKCEPPIVHGDVKPSNVLLGADFGAKLADFGLARVKTQESAAVDERERNDDFGKVSRGGAATPSSIGGGQDDDEEWSK
..   . ..... ...||...| .    |.| |.||.|.||      |..||||||.                                           
PFPE-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE--HIKICDFGLARQL------------------------------------------

LSQSAYGTEADTWSKISPSEIDCRSEISFDGTGQGQAGIKNFLGRKKPWGQRKASASPSSGNGKNTNNGSRDWWWKQESSGQQGGGGGEFSIREYIVDWV
                                                                                                    
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SCENRRGRSRTREWPWNAASSGTAGAAAAGTSSEGKNNVKKKKKQARSGSLEWWAECDDDDELAKRIKAEQKRKKNREWWSGEMQRGKEWWSGELTSNET
                                                                                                    
----------------------------------------------------------------------------------------------------

NNNRKGGRLFETWSRESLSGELTRRRRRERSRSHSRDWWSGDLVSRVSSTPSMRGTVCYVAPEYGGGGVLTEKSDVYSFGVLLLVVVSGRRPLQVVAAPL
                                                   .. ||  |.|||    |  ..|.|..|.|..|   ..|. | .      
--------------------------------------------------TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCILYEMLCGYPPFP------

SEFERANLISWARHAAQAGRGLDLVDPLLAGAYSKEQATLFISLALLCLQRVPSLRPSMSDVVK---------IF
 ...  ..|                               ....   |||. |. ||.  .. .          |
QMQMMFKKIG---------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAK-Un_bx-2.AA TK 111-587 9 1.5e-27 88.84 In-house 1-384 (486) Show / Hide 
Range on Protein: 111-587
Range on HMM: 1-384/486
Sequence Identity: 9% (63 aa)

FSDSHKLGQGGFG---SVFKGTLKNG--------------------------QHIAVKKLDTASLQGEREFMN--------------ELSIMGSMAS---
    .|||.| ||    |.||.....                          .  ||| |   . . ..||.               |...|  | .   
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-SPFVVGLIGFCADSKRK------------MLVYEFMANRS----LQEILFDEKHSVV------------------------------------------
  | .| |.| | ... |            |.| |.|.. .    |.. | . ..                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LQWERRAKIVADVARALAFLHGK---CEPPIVHGDVKPSNVLLGADFG-----------AKLADFGLAR
                               |  ...  . ...|.....|| |    .. .||.|.   |.|.| .             .|.|||||.|
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

VKTQESAAVDERERNDDFGKVSRGGAATPSSIGGGQDDDEEWSKLSQSAYGTEADTWSKISPSEIDCRSEISFDGTGQGQAGIKNFLGRKKPWGQRKASA
...                                                                                                 
QGS-G-----------------------------------------------------------------------------------------------

SPSSGNGKNTNNGSRDWWWKQESSGQQGGGGGEFSIREYIVDWVSCENRRGRSRTREWPWNAASSGTAGAAAAGTSSEGKNNVKKKKKQARSGSLEWWAE
                                                                                                    
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CDDDDELAKRIKAEQKRKKNREWWSGEMQRGKEWWSGELTSNETNNNRKGGRLFETWSRESLSGELTRRRRRERSRSHSRDWWSGDLVSRVSSTPSMRGT
                                                                                      . .|     .   .
--------------------------------------------------------------------------------------VLARDIYSDDDYYR

VC-------------------------------YVAPEYGGGGV---------LTEKSDVYSFGVLL
.                                . |||   ..|          |.||||.|||||.
KSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLM
Kinase IRAK-Un_bx-2.AA LISK 116-266 28 9.5e-27 83.77 In-house 1-159 (296) Show / Hide 
Range on Protein: 116-266
Range on HMM: 1-159/296
Sequence Identity: 28% (46 aa)

KLGQGGFGSVFKGTLK-NGQHIAVKKLDT-----ASLQGEREFMNELSIMGSMASSPFVVGLIGFCAD-SKRKMLVYEFMANRSLQEILFDEK-HSVVLQ
..|.|.||.|.|||..  || .|.|.. .          .. .  |. .| .. . |..|  .| |   ... ..| |..    |...|.|.. |...| 
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNL-RHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLP

WERRAKIVADVARALAFLHGKCEPPIVHGDVKPSNVLLG----ADFGAKLADFGLARVKTQES
|. | ||  |.|.....|| ..   |.| | |  |.|..     .. .|..|||.||. ..|.
WPQRVKIALDIACGMSYLHSMN---IIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCEN
Kinase IRAK-Un_bx-2.AA Pkinase_Tyr 111-260 28 1.7e-26 90.36 Pfam 1-159 (270) Show / Hide 
Range on Protein: 111-260
Range on HMM: 1-159/270
Sequence Identity: 28% (46 aa)

FSDSHKLGQGGFGSVFKGTLK-----NGQHIAVKKL-DTASLQG--EREFMNELSIMGSMASSPFVVGLIGFCA-DSKR--KMLVYEFMANRSLQEILFD
 .  .|||.| ||.|.|||.|     .... |||.| ..|. .    ..||.|..|| .. . | .| |.| |  ...    ..| |.|.. .| . | .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

E---KHSVVLQWERRAKIVADVARALAFLHGKCEPPIVHGDVKPSNVLLGADFGAKLADFGLAR
    |... ...    .. ...|.....|. |    ..| |.   |.|.. .. .| .||||||
HREDKQPLTMKD--LLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLAR
Kinase IRAK-Un_bx-2.AA LRRK 111-260 21 1.1e-24 84.22 In-house 1-226 (351) Show / Hide 
Range on Protein: 111-260
Range on HMM: 1-226/351
Sequence Identity: 21% (50 aa)

FSDSHKLGQGGFG-SVFKGTLKN---------------------------GQHIAVKKLDTA----------------------------------SLQG
.    ..|.|||| .|.......                           .| .|.||...                                   ..  
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

EREFMNELSIMGSMASSPFVVGLIGFCADSKRKMLVYEFMANRSLQEILFDEKHSV------VLQWERRAKIVADVARALAFLHGKCEPPIVHGDVKPSN
 ||| .|..|| ..   | .| |.||| .    ..| |.. . .|.. |...|..       .. |  . ||. ..|.....|| .. |||.| | |. |
FREFRHEVWIMSHL-NHPNIVSLKGFCIH--PLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLH-SHNPPIIHRDLKSPN

VLL-----G-------ADFGAKLADFGLAR
.||     .       |.  ||.||||. |
ILLWSSPQNHSPNYPNAHVCAKIADFGISR
Kinase IRAK-Un_bx-2.AA RIPK 117-264 28 2.9e-23 76.12 In-house 1-161 (290) Show / Hide 
Range on Protein: 117-264
Range on HMM: 1-161/290
Sequence Identity: 28% (46 aa)

LGQGGFGSVFKGTLKNGQHIAVKKL------DTASLQGEREFMNELSIMGSMASSPFVVGLIGFCADSKR------KMLVYEFMANRSLQEILFDEK--H
.| |||| ||| . .   . ..||       .|. .. ||. . |   .  ..   ..| . ||| . .         .| |.|.| || . |  .    
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ

SVVLQWERRAKIVADVARALAFLHGKCEPPIVHGDVKPSNVLLGADFGAKLADFGLARVKTQ
   . |  |  ..  ....  .||..  ||| | | ||.|.|. ..| .|.||||||  ...
HHPDPWPLRCRMIHEISCGMCYLHSM-NPPIIHRDLKPENILVDNNFHVKIADFGLATWMMW
Kinase IRAK-Un_bx-2.AA MLK 111-260 21 8.2e-23 76.05 In-house 1-181 (291) Show / Hide 
Range on Protein: 111-260
Range on HMM: 1-181/291
Sequence Identity: 21% (40 aa)

FSDSHKLGQGGFGSVFKGTLKNGQ----HIAVKKLD----------TASLQGEREFMNELSIMGSMASSPFVVGLIGFCADS-KRKMLVYEFMANRSLQE
.  ....| |.||.|.||. .|       .|||. .          . . . |.|.. .|.|.     .| .. . | |... .   .| |.... || .
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECR-HLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

ILFDEK-----------HSVVLQWERRAKIVADVARALAFLHGKCEPPIVHGDVKPSNVLLGA------DFGAKLADFGLAR
.| ...            ..|   .  ...  ..||....|| .  .||.| | |..|.|. .      .  .| .|||..|
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSR
Kinase IRAK-Un_bx-2.AA TK-Unique 116-260 23 8.6e-22 72.0 In-house 6-181 (294) Show / Hide 
Range on Protein: 116-260
Range on HMM: 6-181/294
Sequence Identity: 23% (42 aa)

KLGQGGFGSVFKGTLKN-------GQHIAVKKLD-TASLQGEREFMNELSIMGSMASSPFVVGLIGFCADSK-RKMLVYEFMANRSLQEILF--------
..|.| || |..|....        ...|||.|   |... ...|..|...| .    | .| ..| | .|  . |...|.... .||  |         
VIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRPAMRQ

---------------DEKHSVVLQWERRAKIVADVARALAFLHG--K-CEPPIVHGDVKPSNVLLGADFGAKLADFGLAR
               |..    .. .. . .  ..|.....|..  | .    ||.|.  .||||. |. .|..|||.||
HQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKI----VHRDLCARNVLLTEDKVCKICDFGMAR
Kinase IRAK-Un_bx-2.AA TyrKc 111-670 9 3.8e-15 22.17 SMART 1-280 (280) Show / Hide 
Range on Protein: 111-670
Range on HMM: 1-280/280
Sequence Identity: 9% (57 aa)

FSDSHKLGQGGFGSVFKGTLKNGQHIAVKKLDTASLQGEREFMNELSIMGSM-ASSPFVVGLIGFCADS-------KRKMLVYEFMANRSLQEILFDEKH
 .  .||| | || |.|||.|  .  |||.|   .   ...||.|..|| .   . | .| |.| | ..       .  |.| |.|.. .|.. | . ..
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

SVVLQWERRAKIVADVARALAFLHGKCEPPIVHGDVKPSNVLLGADFGAKLADFGLARVKTQE------SAAVDE----RER-------------NDD--
   |...   ..  ..|.  ..|| |   ...| |    |.|.|... .| .||||.|  . .      .   .      ..             |.   
K--LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

------------------FGKVSRGGA----ATPSSIGGGQDDDEEWSKLSQ----SAYGTEADTWSKISPSEIDCRSEISFDGTGQGQAGIKNFLGRKK
                  .|.    |      ... .    .. .   .       |                                           
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-------------------------------------------

PWGQRKASASPSSGNGKNTNNGSRDWWWKQESSGQQGGGGGEFSIREYIVDWVSCENRRGRSRTREWPWNAASSGTAGAAAAGTSSEGKNNVKKKKKQAR
                                                                                                    
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SGSLEWWAECDDDDELAKRIKAEQKRKKNREWWSGEMQRGKEWWSGELTSNETNNNRKGGRLFETWSRESLSGELTRRRRRERSRSHSRDWWSGDLVSRV
                                                                                                    
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SSTPSMRGTVCYVAPEYGGGGVLTEKSDVYSFGVLLLVVVSGRRPLQVVAAPLSEFERANLISWARHAAQAGRGLDLVDPLLAGAYSKEQATLFISLALL
                                                                                      . .  .   .. . 
--------------------------------------------------------------------------------------FVCCPDEMYQIMKQ

CLQRVPSLRPSMSDVVKIF
| .. |. ||..|.....|
CWHEDPEDRPTFSEIHECF
Kinase IRAK-Un_bx-2.AA TKL 556-670 16 1e-12 42.13 In-house 232-364 (364) Show / Hide 
Range on Protein: 556-670
Range on HMM: 232-364/364
Sequence Identity: 16% (24 aa)

SMRGTVCYVAPEY----------------GGGGVLTEKSDVYSFGVLLLVVVSGRRPLQVVAAPLSEFERANLISWARH----AAQAGRGLDLVDPLLAG
. .|| .. |||                  .|.  .||.||||||..|  .....|           ..  . ...       . .......   |..  
TQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR----------PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPP

AYS--------KEQATLFISLALLCLQRVPSLRPSMSDVVKIF
  .        .   . ...|.  | .  |. |||.....|..
IWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAK-Un_bx-2.AA IRAK 551-596 45 1.6e-08 26.51 In-house 176-223 (317) Show / Hide 
Range on Protein: 551-596
Range on HMM: 176-223/317
Sequence Identity: 45% (22 aa)

VSSTPSMRGTVCYVAPEYGG--GGVLTEKSDVYSFGVLLLVVVSGRRP
.  |   |||  | .||.     | || |.||||||. || |..|.|.
CMMTSHVRGTTWYMPPEFIRDPQGQLTKKTDVYSFGIVLLEVLTGCRA
Kinase IRAK-Un_bx-2.AA MLK 555-587 38 1.5e-05 15.38 In-house 191-226 (291) Show / Hide 
Range on Protein: 555-587
Range on HMM: 191-226/291
Sequence Identity: 38% (14 aa)

PSMRGTVCYVAPEY---GGGGVLTEKSDVYSFGVLL
.|..||. . |||      ..  .||.||.|.||.|
MSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVL
Kinase IRAK-Un_bx-2.AA LRRK 549-587 31 1.6e-05 15.52 In-house 225-272 (351) Show / Hide 
Range on Protein: 549-587
Range on HMM: 225-272/351
Sequence Identity: 31% (15 aa)

SR----VSS--TPSMRGTVCYVAPEYGGGG---VLTEKSDVYSFGVLL
||    . .  .. . |.  ..|||  ...   . |||.|.||||..|
SRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMIL
Kinase IRAK-Un_bx-2.AA RIPK 573-596 41 2.5e-05 14.06 In-house 204-227 (290) Show / Hide 
Range on Protein: 573-596
Range on HMM: 204-227/290
Sequence Identity: 41% (10 aa)

VLTEKSDVYSFGVLLLVVVSGRRP
| |.|.|||||....  | ... |
VVTPKYDVYSFAIVMWEVLTQKHP
Kinase IRAK-Un_bx-2.AA TK-Unique 565-587 53 6.1e-05 13.12 In-house 204-229 (294) Show / Hide 
Range on Protein: 565-587
Range on HMM: 204-229/294
Sequence Identity: 53% (14 aa)

APEYGG--GGVL-TEKSDVYSFGVLL
|||.    .|.  |.||||.|||||.
APESLKCYHGMYHTTKSDVWSFGVLM
Kinase IRAK-Un_bx-2.AA TK 648-670 26 0.00019 9.98 In-house 464-486 (486) Show / Hide 
Range on Protein: 648-670
Range on HMM: 464-486/486
Sequence Identity: 26% (6 aa)

LALLCLQRVPSLRPSMSDVVKIF
| . | .. |. ||..|.... .
LMQQCWHYDPEDRPTFSQLHEQL
Kinase IRAK-Un_bx-2.AA TK-Unique 652-670 31 0.000743 9.32 In-house 276-294 (294) Show / Hide 
Range on Protein: 652-670
Range on HMM: 276-294/294
Sequence Identity: 31% (6 aa)

CLQRVPSLRPSMSDVVKIF
|.|..|. ||| .......
CWQWEPEERPSFRQIKHRL
Kinase IRAK-Un_bx-2.AA LRRK 651-672 40 0.001008 9.03 In-house 330-351 (351) Show / Hide 
Range on Protein: 651-672
Range on HMM: 330-351/351
Sequence Identity: 40% (9 aa)

LCLQRVPSLRPSMSDVVKIFSG
.| |  |  ||..|..||. | 
HCWQHDPKKRPHFSQIVKRLSQ
Kinase IRAK-Un_bx-2.AA Pkinase_Tyr 572-587 68 0.001133 13.06 Pfam 189-204 (270) Show / Hide 
Range on Protein: 572-587
Range on HMM: 189-204/270
Sequence Identity: 68% (11 aa)

GVLTEKSDVYSFGVLL
|. |.||||.|||||.
GKFTTKSDVWSFGVLM
Kinase IRAK-Un_bx-2.AA MLK 652-670 31 0.001393 8.45 In-house 273-291 (291) Show / Hide 
Range on Protein: 652-670
Range on HMM: 273-291/291
Sequence Identity: 31% (6 aa)

CLQRVPSLRPSMSDVVKIF
| .  |. |||.. .|...
CWNQDPHKRPSFRQIVQHL
Kinase IRAK-Un_bx-2.AA LISK 575-588 50 0.004631 5.56 In-house 217-230 (296) Show / Hide 
Range on Protein: 575-588
Range on HMM: 217-230/296
Sequence Identity: 50% (7 aa)

TEKSDVYSFGVLLL
.|..||.|||..|.
DESCDVFSFGIVLC
Kinase IRAK-Un_bx-2.AA Pkinase 552-598 33 0.070174 7.73 Pfam 167-213 (293) Show / Hide 
Range on Protein: 552-598
Range on HMM: 167-213/293
Sequence Identity: 33% (16 aa)

SSTPSMRGTVCYVAPEYGG-GGVLTEKSDVYSFGVLLLVVVSGRRPLQ
| . .  ||  |.|||    |   . |.|..|.|..|  ...|| | .
S-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFP
Kinase IRAK-Un_bx-2.AA LISK 645-670 30 0.212995 0.07 In-house 271-296 (296) Show / Hide 
Range on Protein: 645-670
Range on HMM: 271-296/296
Sequence Identity: 30% (8 aa)

FISLALLCLQRVPSLRPSMSDVVKIF
|. |.. |    |. ||| ...|...
FLDLCFDCCKYDPKNRPSFKEIVQWL
Kinase IRAK-Un_bx-2.AA Pkinase_Tyr 650-670 23 0.305076 4.83 Pfam 250-270 (270) Show / Hide 
Range on Protein: 650-670
Range on HMM: 250-270/270
Sequence Identity: 23% (5 aa)

LLCLQRVPSLRPSMSDVVKIF
..| .  |. ||..|... ..
KQCWHYDPEDRPTFSEIHEQL
Kinase IRAK-Un_bx-2.AA Pkinase 652-670 28 8.519288 0.36 Pfam 273-293 (293) Show / Hide 
Range on Protein: 652-670
Range on HMM: 273-293/293
Sequence Identity: 28% (6 aa)

CLQRVPSLRPSMSDVVKI--F
||.. |. ||.  ....   |
CLCKDPKKRPTAEQILQHPWF