Gene IRAK-Un_dc (S.moellendorffii)

IRAK-Un_dc

Species: S.moellendorffii
Alias: IRAK-Un_dc
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
IRAK-Un_dc.AA Protein None 339 None Fasta, JSON
IRAK-Un_dc.NA RNA None 1020 None Fasta, JSON
IRAK-Un_dc.kin_dom Protein Kinase Domain None 167 None Fasta, JSON

Protein domain

Protein domains of IRAK-Un_dc.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IRAK-Un_dc.AA TKL 46-205 26 4.2e-39 136.22 In-house 1-204 (364) Show / Hide 
Range on Protein: 46-205
Range on HMM: 1-204/364
Sequence Identity: 26% (56 aa)

IGEGSYGHVYKGTLHR----------TNVAVKVLRHDSWQGPQEFEQE--------VRKLTRISKISNKHGKIKVEVL---SRLHHPHIVLLLG------
||.|..| ||||...           . ||||... .. .   . .||              ... . .  . ..|..   |||.||.||...|      
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSD-M-QLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPP

---------GNPEKKCLVYEYLENGSLEDRLFCKDDSPPISCLTRYQIAVEVGTALLFLHKAKP-----QPIVLRDLKPSNILLDKNYN-----------
         |.. . |.|.|| ..|||...|             | ..| ..  .. .||  .|      ||. ||||..|||.|.|..           
CGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNA

---SKISDVGLARFM
    ||.| ||.|||
DWCCKICDFGLSRFM
Kinase IRAK-Un_dc.AA MLK 40-205 26 2e-28 95.82 In-house 1-183 (291) Show / Hide 
Range on Protein: 40-205
Range on HMM: 1-183/291
Sequence Identity: 26% (53 aa)

FSENNKIGEGSYGHVYKGTLHRTN-----VAVKVLRHDSWQGPQE-------FEQEVRKLTRISKISNKHGKIKVEVLSRLHHPHIVLLLGG---NPEKK
. .  .||.||.| |.||. . ..     ||||  |..     ..       ||.|.|.| ..|.  |              || |. ..|.   .| . 
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNN--------------HPCIIQFYGVCLQPPCHF

CLVYEYLENGSLEDRLFCKDDSPP-----------ISCLTRYQIAVEVGTALLFLHKAKPQPIVLRDLKPSNILLD------KNYNSKISDVGLARFM
|.| ||.|.||| . |  ... .            ..     ..|. .  .. .||. .|.||. ||||..|||.|      .. . ||.| |..|..
CIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDW
Kinase IRAK-Un_dc.AA IRAK 102-204 44 2.4e-28 97.62 In-house 54-162 (317) Show / Hide 
Range on Protein: 102-204
Range on HMM: 54-162/317
Sequence Identity: 44% (48 aa)

VEVLSRLHHPHIVLLLG--GNPEKKCLVYEYLENGSLEDRLFCKD-DSPP--ISCLTRYQIAVEVGTALLFLHKAKPQ-PIVLRDLKPSNILLDKNYNSK
..|..|..||.|| |.|    ... ||||.|. |||||||| | | . ||   |  .|  |.   . .. ||| . |  ||  .| |..|||||.. . |
LKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQCPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPK

ISDVGLARF
|.| ||.||
ICDFGLHRF
Kinase IRAK-Un_dc.AA Pkinase 40-218 26 6.6e-23 82.08 Pfam 1-177 (293) Show / Hide 
Range on Protein: 40-218
Range on HMM: 1-177/293
Sequence Identity: 26% (51 aa)

FSENNKIGEGSYGHVYKGTLHRTN--VAVKVLRHDSWQGPQEFEQEVRKLTRISKISNKHGKIKVEVLSRLHHPHIVLLLGGN--PEKKCLVYEYLENG-
.    |||.||.| |||.. . |.  ||||... .  . ... .. .|                .... ||.||.|| |..    . . ..| ||.|.| 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRL-------------SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGL

---SLEDRLFCKDDSPPI--SCLTRYQIAVEVGTALLFLHKAKPQPIVLRDLKPSNILLDKNYNS----KISDVGLARFM---PGDATSVRSTSPW
   .| |..   ... ..  |  .   .. ..  .| ..|.     |. |||||.|||.|.|..     ||.| |||...    . .|..  |...
YVMDLFDYIST-WRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDYNNS-MTTFCGTPWY
Kinase IRAK-Un_dc.AA Ubox 271-333 33 2.8e-21 77.93 SMART 1-72 (72) Show / Hide 
Range on Protein: 271-333
Range on HMM: 1-72/72
Sequence Identity: 33% (24 aa)

LFLCPILQEVMEYPVIASDG--YTYEYDAIIRWLQK---SDASPMTNLRL-ENKNLTPN---RVVRSAICEW
 |.|||  |.|. |||...|  .||.  .| .||..    . .|||.  | . ..|.||    .....| .|
EFCCPISLEIMKDPVILPSGKGQTYDRRCIEKWLKEGGQHGTCPMTRQPLPTHEDLIPNKTGHALKPKIQHW
Kinase IRAK-Un_dc.AA LRRK 104-203 32 2.1e-19 65.28 In-house 110-226 (351) Show / Hide 
Range on Protein: 104-203
Range on HMM: 110-226/351
Sequence Identity: 32% (38 aa)

VLSRLHHPHIVLLLGGNPEKKCLVYEYLENGSLEDRLFCKDDSP------PISCLTRYQIAVEVGTALLFLHKAKPQPIVLRDLKPSNILL---D-----
..|.|.||.|| |.|   .  |.| ||. .|.| ..|. |  ..       ||  ....||...  .. .||...| ||. ||||. ||||   .     
IMSHLNHPNIVSLKGFCIHPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNP-PIIHRDLKSPNILLWSSPQNHSP

----KNYNSKISDVGLAR
     ... ||.| |. |
NYPNAHVCAKIADFGISR
Kinase IRAK-Un_dc.AA TK 40-217 17 5.4e-19 59.61 In-house 1-321 (486) Show / Hide 
Range on Protein: 40-217
Range on HMM: 1-321/486
Sequence Identity: 17% (60 aa)

FSENNKIGEGSYG---HVYKGTLHR---------------------------TNVAVKVLRHDSWQGPQEFEQ-------EVRKLTRISKISNKHG----
    .|.||| .|    ||||....                           | ||||.|. .. . ..||..       .              |    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDG--------------GEDFL

--KIKVEVLS--RLHHPHIVLLLG----GNP----------EKKCLVYEYLENGS----LEDRLF-----------------------------------
      ....   .|||.|| |.|    | |          |  ..| || ..|.    | | |                                    
EEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITY

------------------CKDDSPPISCLTRYQ-------------------IAVEVGTALLFLHKAKP---QPIVLRDLKPSNILLDKNYN--------
                   ||..||..    .|                   ... .  .. .||. .    | .| |||   |.|...|..        
SHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGC

---SKISDVG--------LARFMPGDATSVRSTSP
    ||.| |        ||| .. |   .|..|.
GPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSY
Kinase IRAK-Un_dc.AA RIPK 46-205 30 3e-18 58.79 In-house 1-159 (290) Show / Hide 
Range on Protein: 46-205
Range on HMM: 1-159/290
Sequence Identity: 30% (52 aa)

IGEGSYGHVYKGT--LHRTNVAVKVLRHDSWQGPQEFEQEVRKLTRISKISNKHGKIKVEVLSRLHHPHIVLLLGGNPEK--------KCLVYEYLENGS
.| |. | |.| .   ... ||.|.      . .   .||. .. .  |. .|           | . ||| ..|   ..          .| || ||||
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHM-DDQERMYQKEEAKHMHK-----------LRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGS

LEDRLFCKD--DSPPISCLTRYQIAVEVGTALLFLHKAKPQPIVLRDLKPSNILLDKNYNSKISDVGLARFM
|.. |  |     .|.    |  . .|.  .  .||  .| ||  |||||.|||.| |.. ||.| ||| .|
LWHFLHTKWPYQHHPDPWPLRCRMIHEISCGMCYLHSMNP-PIIHRDLKPENILVDNNFHVKIADFGLATWM
Kinase IRAK-Un_dc.AA TKL-Unique 102-204 31 5.9e-17 56.47 In-house 46-166 (290) Show / Hide 
Range on Protein: 102-204
Range on HMM: 46-166/290
Sequence Identity: 31% (39 aa)

VEVLSRLH-HPHIVLLLGGNP----EKK--CLVYEYLENGSLEDRLF-------CKDDSPPISCLTRYQIAVEVGTALLFLHKAKPQPIVLRDLKPSNIL
| ....|| || ||.. |.        .  |.| ||.. ||| | |           .. ... . |...|  .  .. .||  .|  |  ||||.||.|
VNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFL

LDKN-----YNSKISDVGLARF
.| |     .| ||.|.||..|
VDNNSNIAEWNIKICDFGLSKF
Kinase IRAK-Un_dc.AA U-box 267-335 30 1.2e-15 47.18 Pfam 1-76 (81) Show / Hide 
Range on Protein: 267-335
Range on HMM: 1-76/81
Sequence Identity: 30% (23 aa)

AAPTLFLCPILQEVMEYPVIASDG-YTYEYDAIIRWLQK-----SDASPMT-NLRLENKNLTPNRVVRSAICEWRA
 .|  |.|||  | |  |||...| .||.  .| |.|..     .  .|.. .  |   .|.||. .. .| .| .
DIPDEFCCPIMWELMKDPVILPSGKITYDRSTIERHLLSEAWGRDHTDPFNGRQPLTHDMLIPNYELKEKIDHWLE
Kinase IRAK-Un_dc.AA Dicty4 102-205 29 1.1e-13 42.18 In-house 49-164 (277) Show / Hide 
Range on Protein: 102-205
Range on HMM: 49-164/277
Sequence Identity: 29% (35 aa)

VEVLSRLHHPHIVLLLGG------NPEKKCLVYEYLENGSLEDRLFC------KDDSPPISCLTR-YQIAVEVGTALLFLHKAKPQPIVLRDLKPSNILL
|. .. . ||.|.|..|       .|.| | | ||.  |.|.  |        . .... .  .|  ..|  .   .  ||   |  |. ||||..|.| 
VHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV-IIHRDLKSHNLLV

DKNYNSKISDVGLARFM
|||.. |..| ||.. |
DKNWRVKVCDFGLSQYM
Kinase IRAK-Un_dc.AA CZAK 102-205 32 3.6e-13 44.31 In-house 51-172 (279) Show / Hide 
Range on Protein: 102-205
Range on HMM: 51-172/279
Sequence Identity: 32% (40 aa)

VEVLSRLHHPHIVLLLG----GNPEKKCLVYEYLENGSLEDRLFCKDDSPPISC--LTRYQIAVEVGTALLFLHK-AKPQPIVLRDLKPSNILLDKNYN-
| ..| | || .|  ||    ..|. .| | |. . |||  | .  | .  .      . ..|. .     .||   || ||. |||  .||||| .|  
VSIMSKLCHPNCVQFLGACSEDGPNHHCIVMEWMGGGSL--RRLLTDHYFYHKQNPHLQWNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDHSYTP

------------SKISDVGLARFM
             ||.| || | |
KNPVVSSRQDIICKINDFGLSREM
Kinase IRAK-Un_dc.AA CAMK 45-141 16 4.1e-13 37.89 In-house 1-152 (425) Show / Hide 
Range on Protein: 45-141
Range on HMM: 1-152/425
Sequence Identity: 16% (27 aa)

KIGEGSYGHVYKGTLHRTN--------------VAVKVLRHD-------------------------SW---QGPQEFEQEVRKLTRISKISNKHGKIKV
..|.||.| |....  .|.              ||.|..  .                         .|   .  .....|.. . ....|.|       
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGN-------

EVLSRLHHPHIVLLLG--------------GNPEK--------KCLVY---EYLENGSLEDRLF
    .|.||.|. |.                . .|         ..|    || ..| | |.||
----KLDHPNIIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLF
Kinase IRAK-Un_dc.AA TyrKc 40-273 19 5.7e-13 -13.01 SMART 1-280 (280) Show / Hide 
Range on Protein: 40-273
Range on HMM: 1-280/280
Sequence Identity: 19% (60 aa)

FSENNKIGEGSYGHVYKGTLHRTNVAVKVLRHDSWQGPQEFEQEVRKLTRISKISNKHGKIKVEVLSRL--HHPHIVLLLGG--NP-------EKKCLVY
 . . |.||| .| |||||.  ..||||.|..|.    ..| .| |                  ....|  |||.|| |.|    .       |  ..| 
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA---REDFMREAR------------------IMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVM

EYLENGSLEDRL-FCKDDSPPISCLTRYQIAVEVGTALLFLHKAKPQPIVLRDLKPSNILLDKNYNSKISDVGLARFMPGD--------ATSV----RST
|| ..|.| |.|  ....   ..  .  .... .     .||.    ... |||   |.|...|.  |||| ||.|.   |          ..     . 
EYMPHGDLKDYLRKHRPK---LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGK

---------------------------------------SPWP------LAAATQLACIGLNCAECQRKNRPEL----------ENVLQMLETMNHLFRS
                                       .|.|      . ..  ....     .  |  .|.           . . |. ..  | .  
TMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYV----KQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWH-EDP

EERPKSAAPTLFL
|.||  ..   ..
EDRPTFSEIHECF
Kinase IRAK-Un_dc.AA S_TKc 40-286 20 1.3e-12 8.1 SMART 1-231 (231) Show / Hide 
Range on Protein: 40-286
Range on HMM: 1-231/231
Sequence Identity: 20% (57 aa)

FSENNKIGEGSYGHVYKGTLHR--TNVAVKVLRHDSWQGPQEFEQEVRKLTRISKISNKHGKIKVEVLSRLHHPHIVLLLGGNP-EKKCLVYEYLEN--G
.   .|||.|..| |||.. ..    ||.|...                         .| .  ...|.. |||.|| |..    .. ..| ||...  |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------------------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLG

SLEDRLFCKDDSPP---ISCLTRYQIAVEVGTALLFLHKAKPQPIVLRDLKPSNILLDKNYNSKISDVGLARFMPGDATSVRSTSPW----PLAAATQ--
.| |..  .   ..   ..  .   .. ..  || ..|. .   |. |||||.|||||.  . ||.| ||||..    |..  |  .     |   .   
DLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE--HIKICDFGLARQL----TTFCGTPWYMAPEVL-GYGKCK

-----LACIGLNCAECQRKNRPELENVLQMLETMNHLFRSEERPKSAAPTLFLCPILQ---------EVME-------YPVI
     . ||   ..  .   . ... .....              |     |.. .||         |...        | .
CDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase IRAK-Un_dc.AA IRAK 40-70 45 1.6e-10 33.63 In-house 1-33 (317) Show / Hide 
Range on Protein: 40-70
Range on HMM: 1-33/317
Sequence Identity: 45% (15 aa)

FSENNKIGEGSYGHVYKGTLHRTN--VAVKVLR
|...|.|||| .| ||.| .. |   .||| |.
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLK
Kinase IRAK-Un_dc.AA Pkinase_Tyr 40-91 27 1.9e-09 32.65 Pfam 1-62 (270) Show / Hide 
Range on Protein: 40-91
Range on HMM: 1-62/270
Sequence Identity: 27% (17 aa)

FSENNKIGEGSYGHVYKGTLH------RTNVAVKVLRHDSWQG---PQEFEQEVRKLTRI-S
 . . |.|||..|.|||||..      .. ||||.|.... .     ..| .|.. .. . .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGH
Kinase IRAK-Un_dc.AA CAMK 176-208 38 1.2e-08 23.27 In-house 200-249 (425) Show / Hide 
Range on Protein: 176-208
Range on HMM: 200-249/425
Sequence Identity: 38% (19 aa)

IVLRDLKPSNILLDKN-----------------YNSKISDVGLARFMPGD
|| ||||| |||||.|                 .| ||.| |.|......
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPG
Kinase IRAK-Un_dc.AA TKL-Unique 44-85 44 2.1e-08 25.92 In-house 3-47 (290) Show / Hide 
Range on Protein: 44-85
Range on HMM: 3-47/290
Sequence Identity: 44% (20 aa)

NKIGEGSYGHVYKGTLHRTNVAVKVLRHDSWQGPQ---EFEQEVR
||||||.|| ||||. ... ||.|..   . . ..   ||| ||.
NKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVN
Kinase IRAK-Un_dc.AA Dicty4 40-69 50 5.1e-08 23.01 In-house 1-30 (277) Show / Hide 
Range on Protein: 40-69
Range on HMM: 1-30/277
Sequence Identity: 50% (15 aa)

FSENNKIGEGSYGHVYKGTLHRTNVAVKVL
    ..||.||.| |||||   . ||||.|
INIEQRIGKGSFGEVYKGTWRGKEVAVKKL
Kinase IRAK-Un_dc.AA LRRK 40-69 15 1.4e-07 22.89 In-house 1-59 (351) Show / Hide 
Range on Protein: 40-69
Range on HMM: 1-59/351
Sequence Identity: 15% (9 aa)

FSENNKIGEGSYG-HVYKGTLHR----------------------------TNVAVKVL
. ....||.|..|  ||.... .                            ..||.|..
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKW
Kinase IRAK-Un_dc.AA Pkinase_Tyr 102-219 27 1e-06 22.9 Pfam 54-177 (270) Show / Hide 
Range on Protein: 102-219
Range on HMM: 54-177/270
Sequence Identity: 27% (35 aa)

VEVLSRL-HHPHIVLLLGGNP--EKK---CLVYEYLENGSLEDRLFCK-DDSPPISCLTRYQIAVEVGTALLFLHKAKPQPIVLRDLKPSNILLDKNYNS
..... | |||.|| |.|     ..    ..| || ..|.| | |  . .| .|..  .  |.....  .. .|.  .   .. |||   |.|...|   
AKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVV

KISDVGLARFM-PGDAT-SVRSTSPWP
||.| |||| . . |    .|. ...|
KICDFGLARDIYNDDYYYRKRGGGKLP
Kinase IRAK-Un_dc.AA CZAK 40-84 27 0.000396 11.07 In-house 1-51 (279) Show / Hide 
Range on Protein: 40-84
Range on HMM: 1-51/279
Sequence Identity: 27% (14 aa)

FSENNKIGEGSYGHVYKGTLHRTNVAVKVLRHDSWQGPQE------FEQEV
.     ||.| .| |||.    . ||.| .  ..     |      |. ||
LKFGQTIGQGFFGEVYKAYWRGKDVAIKIIHRNQFRNKDENKEENMFQKEV
Kinase IRAK-Un_dc.AA IRAK 216-251 19 0.094287 2.19 In-house 282-317 (317) Show / Hide 
Range on Protein: 216-251
Range on HMM: 282-317/317
Sequence Identity: 19% (7 aa)

SPWPLAAATQLACIGLNCAECQRKNRPELENVLQML
.|.| . .  ...  . |..   ..|.. . |.| |
PPCPPNMEKEMCQCACCCGHHRANRRCDMAWVMQQL