Gene IRAK-Un_bd (S.moellendorffii)

IRAK-Un_bd

Species: S.moellendorffii
Alias: IRAK-Un_bd
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
IRAK-Un_bd.AA Protein None 1012 None Fasta, JSON
IRAK-Un_bd.NA RNA None 3039 None Fasta, JSON
IRAK-Un_bd.kin_dom Protein Kinase Domain None 209 None Fasta, JSON

Protein domain

Protein domains of IRAK-Un_bd.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
B_lectin IRAK-Un_bd.AA B_lectin 111-211 27 1.6e-22 78.95 Pfam 1-137 (137) Show / Hide 
Range on Protein: 111-211
Range on HMM: 1-137/137
Sequence Identity: 27% (38 aa)

RPVVLWTANRD---RYF-----GEGATLDFGA-DGELIVRENG---LT--VWST--GTAGKG---VTEMCITNLGNLLLR-NST--DHIIWQS--FDSPS
 . | |.||||   .       ....|| . . || |.. ..|    .  ||||  .|.|.|    . . ... ||| |. ..   ....|||  || |.
NQTVVWVANRDLTGNPVTDSSNNGNYTLTMQNRDGNLVLYDGGNGGSVRPVWSTNNNTSGSGSANNCRAQMQDSGNLVLYDDNNDSNNVLWQSNTFDHPT

DT-FPIQV----AFKP-GNR----LVSWASPK--DSS
|| .| .      ..  . .    |.||.|.   | |
DTWLPGMKLGWDNNVTIYMNWIGYLTSWKSNTNYDPS
B_lectin IRAK-Un_bd.AA B_lectin 55-185 21 3e-06 20.89 SMART 1-126 (126) Show / Hide 
Range on Protein: 55-185
Range on HMM: 1-126/126
Sequence Identity: 21% (31 aa)

LDTDGLSGRWAGYWSNTTYIELGDITFQLWFLTYDARNFTLSLVAMREPTQEWELYRPVVLWTA--NRDRYFGEG---ATLDFGADGELIVRENGLTVWS
  | .   .. . .| .  ..||. ||.          .... .    . .        |.| |  |||.   .|   ..| .. ||.|..   . .|||
DNTLSSGQTLVSGNSLFE-FYLGFFTFIMQ--------WCNGIWYKNISNK-----QRTVVWVAQPNRDNPVHDGNNSCYLTMQSDGNLVIYD-NRPVWS

TGTA-GKGVTEMCITNLGNLLLRNST----DHIIWQSFDSP
..|. ..|.. .  .  ||. ....     . .||||||.|
SNTTRNNGNYVAVLQDDGNFVIYDPDDNDSGNFIWQSFDHP
PAN_AP IRAK-Un_bd.AA PAN_AP 384-458 18 0.000977 15.13 SMART 1-85 (85) Show / Hide 
Range on Protein: 384-458
Range on HMM: 1-85/85
Sequence Identity: 18% (16 aa)

CEPHEIVRMEGVDYFSTNFS----TELPVVDESECRRRCEENCSCMAAFFKE-KSCFQTH--EPIQSMI------TGEYTGLLKVAKT
|...  |||... .  .. .     .. |... ||...| .||||... . . |.|   .   . ...       ...  |     |.
CCDDCFVRMPNMKL--FSPIVNWVDVI-VMSLEECMQKCLNNCSCRSFMYYNTKGCHLWSWDSHLGDPRQFKRFMKFPNQGVDYYEKN
Kinase IRAK-Un_bd.AA TKL 539-824 22 2.3e-66 226.77 In-house 1-364 (364) Show / Hide 
Range on Protein: 539-824
Range on HMM: 1-364/364
Sequence Identity: 22% (89 aa)

LGQGGYGSVYRGSLED---------GNQVAVKKLQGSN----------------------------QNSRDFYAEVASLARTNHLNLVKFIGFCAEGPR-
.|.||.| ||.| .           |. |||||.   |                            ..   .  |. .. |..| |.|.|.|.| ..|  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-----------KRLLVYEFVPNGSLEKWIFGDDGGDDSSSQQQDGSGGLSWDCKFRIAVGTAQGLCYLHEECA-----DRIIHLDLKPENVLVDIGFV--
           .  .|.|..|.|||.  .                     |. ..|.| ..|.|..||| .         ||| |||..|.|||  .   
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNV

------------PKIADFGLSKLMNRE-----------------VTYLQMTSMRGTPGYLAPEYLQ----------------VGTITEKSDVFSFGVLLL
            .||.|||||. |...                 ..  .  . .|||...||| |.                 .. .||.||.|||..| 
SNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLW

EIITGCRNKYMSSDYLRSFSLGGFSRQKSFTKSIS----KTRKNLCDGGSSGGIADKYQ--------AAGMARLKAVAYLCVQDDPDMRPSMSTALKMM
||.|.||                .. .....  ..       .  || |    | .  |           . ..|  .  | . ||. |||... || .
EILTRCR---------------PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Pkinase IRAK-Un_bd.AA Pkinase 533-742 26 2.9e-49 174.79 Pfam 1-208 (293) Show / Hide 
Range on Protein: 533-742
Range on HMM: 1-208/293
Sequence Identity: 26% (61 aa)

GGFSKCLGQGGYGSVYRGSLEDGNQ-VAVKKLQGSNQNSRDFYA-----EVASLARTNHLNLVKFIGFCAEGPRKRLLVYEFVPNG----SLEKWIFGDD
  . ...|.|..|.||..   . .. ||||..  ....|   ..     |.. ..| || | |...... . ...  .| |....|    .|  .| .  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYIST--

GGDDSSSQQQDGSGGL--SWDCKFRIAVGTAQGLCYLHEECADRIIHLDLKPENVLVDIGFVP----KIADFGLSKLMNREVTYLQMTSMRGTPGYLAPE
          . .|..  |..   ...  ...|| |.|..   .||| ||||||.|.|   ..    ||.||||.|... .  .  ||.  |||.|.|||
----------WRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPE

YLQ-VGTITEKSDVFSFGVLLLEIITG
 ..    .. |.|..|.|..| | ..|
VIRGGQYYGPKVDMWSCGCILYEMLCG
Kinase IRAK-Un_bd.AA IRAK 535-744 37 6.8e-44 152.14 In-house 1-222 (317) Show / Hide 
Range on Protein: 535-744
Range on HMM: 1-222/317
Sequence Identity: 37% (88 aa)

FSK--CLGQGGYGSVYRGSLEDGNQ--VAVKKL---QGSNQNS--RDFYA---EVASLARTNHLNLVKFIGFCAEGPRKRLLVYEFVPNGSLEKWIFGDD
|.|   .|.||.| |||| . ...   .|||||     ...|.  . | .   |. ...|  | |.| . |.|.|.. .  |||.. ||||||    .  
FHKDNRIGEGGFGCVYRGQW-KNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQ-CHCLVYPYMPNGSLEDRLWC--

GGDDSSSQQQDGSGG---LSWDCKFRIAVGTAQGLCYLHEEC-ADRIIHLDLKPENVLVDIGFVPKIADFGLSKLM----NREVTYL--QMTS-MRGTPG
         |||..    |||   . |. ||| |. .||.   .  ||| | |. |.| |  |.|||.||||        ..| . .   |||  |||  
---------QDGQCPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTW

YLAPEYLQ--VGTITEKSDVFSFGVLLLEIITGCR
|..||..   .| .| |.||.|||. |||..||||
YMPPEFIRDPQGQLTKKTDVYSFGIVLLEVLTGCR
Kinase IRAK-Un_bd.AA MLK 535-742 28 1.1e-43 149.49 In-house 3-232 (291) Show / Hide 
Range on Protein: 535-742
Range on HMM: 3-232/291
Sequence Identity: 28% (67 aa)

FSKCLGQGGYGSVYRGSLEDGN----QVAVKKLQ-------GSNQNSRDFYAEVASLARTNHLN----LVKFIGFCAEGPRKRLLVYEFVPNGSLEKWIF
|.. .| |..|.|..|     .     ||||.          .   ..||  |.  |.. .|.|     ..| | |.. | . ..| |....|||   . 
FHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLH

G-DDGGDDSSSQQQDGSGGLSWDCKFRIAVGTAQGLCYLHEECADRIIHLDLKPENVLVDI------GFVPKIADFGLSKLMNRE-VTYLQMTSMRGTPG
| .....|.  .|.  ..  . | ....|.  |.|. |||..  . ||| |||. |.|.|       . . ||.|||.|. ...   .   |.|..||. 
GARSKWMDANHNQK-NDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTN---MMSNAGTYA

YLAPEYL---QVGTITEKSDVFSFGVLLLEIITG
. ||| .   . .. .||.||.|.||.| |..|.
WMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTR
Kinase IRAK-Un_bd.AA Dicty4 535-742 35 2.8e-42 138.9 In-house 3-213 (277) Show / Hide 
Range on Protein: 535-742
Range on HMM: 3-213/277
Sequence Identity: 35% (79 aa)

FSKCLGQGGYGSVYRGSLEDGNQVAVKKLQGSNQNS-----RDFYAEVASLARTNHLNLVKFIGFCA---EGPRKRLLVYEFVPNGSLEKWIFGDDGGDD
. . .|.|..|.||.|.   | .||||||   |||.      .| .||. ..   | |...| | |      | | . | |..| |.|.. .      | 
IEQRIGKGSFGEVYKGTWR-GKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLH-----DK

SSSQQQDGSGGLSWDCKFR---IAVGTAQGLCYLHE-ECADRIIHLDLKPENVLVDIGFVPKIADFGLSKLMNREVTYLQ-MTSMRGTPGYLAPEYLQVG
 | |||  |  |.|    |   .|  .|.|. .||.  .  .|||.|||. | |||. .. |..|||||..| .. .  . .... |||.. ||| ..  
PSEQQQ--SIKLDWPLIKRAMRMAFDAARGMNWLHCCNP--VIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQ

TITEKSDVFSFGVLLLEIITG
  .||.||.||| .| || |.
PYNEKADVYSFGIVLWEILTR
Kinase IRAK-Un_bd.AA TKL-Unique 535-744 31 2.1e-38 133.05 In-house 1-226 (290) Show / Hide 
Range on Protein: 535-744
Range on HMM: 1-226/290
Sequence Identity: 31% (73 aa)

FSKCLGQGGYGSVYRGSLEDGNQVAVKKLQ----GSNQNSRDFYAEVASLARTN-HLNLVKFIGFCAE---GPRKRLLVYEFVPNGSLEKWIFGDDGGDD
|.. .|.||||.||.|    | .||.|..      ||. ...|. ||  . . . | |.|...|.|.     | .. .| |..| ||| . .        
FWNKIGEGGYGQVYKGKWR-GYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

SSSQQQDGSGGLSWDCKFRIAVGTAQGLCYLHEECADRIIHLDLKPENVLVDIG-----FVPKIADFGLSKLMNRE-VTYLQMT------SMRGTPGYLA
  ..  .    |..  . ..|   |||..||| . .  |||.|||. |.||| .     .  ||.||||||. ...  . . .       .  |.. ..|
NNNNNCK----LNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMA

PEYLQV--GTITEKSDVFSFGVLLLEIITGCR
|| |     ...|||||.|||. | ||.|...
PEVLRMNFCQYSEKSDVYSFGIVLWEIATRKI
Kinase IRAK-Un_bd.AA TK 535-824 15 1.3e-35 116.25 In-house 3-486 (486) Show / Hide 
Range on Protein: 535-824
Range on HMM: 3-486/486
Sequence Identity: 15% (82 aa)

FSKCLGQGGYG---SVYRGSLEDGN--------------------------QVAVKKLQ-GSNQNSRDFYA--------------EVASLARTN-----H
. | ||.| .|    ||.| ....|                          .|||| |  |.......| .              |.. ..  .     |
LGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHH

LNLVKFIGFCAEGPRK-----------RLLVYEFVPNGS----LEKWIF--GDDGGDDSSSQQQDGSGG-------------------------------
 |.|...| | .|  |            ..| |..|.|.    | ..     ... . ... .   ...                               
PNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDD

-----------------------------LSWDCKFRIAVGTAQGLCYLHEE----CADRIIHLDLKPENVLVDIGFV-----------PKIADFG----
                             |.  ..  ...  |.|. |||.        ...| ||   |.||. . |            ||||||    
DLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

----LSKLMNREVTYLQMTSMRGTPG------------------------YLAPEYLQ---------VGTITEKSDVFSFGVLLLEIITGC-RNKY--MS
    |.. ....  |  ..| ... .                        ..||| |.          |. |.||||.|||||. || | .    |  ||
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS

S-----DYLRSFSLGGFSRQKSFTKSISKTRKNLCDGGSSGGIADKYQAAGM------------ARLK------------------------AVAYLCVQ
.     |                             | .   . .. .. |.             |..                         .   | .
NQDVWKD-----------------------------G-DNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWH

DDPDMRPSMSTALKMM
 ||. ||..|. ....
YDPEDRPTFSQLHEQL
Kinase IRAK-Un_bd.AA Ciliate-E2 535-742 21 8.7e-34 113.35 In-house 3-292 (365) Show / Hide 
Range on Protein: 535-742
Range on HMM: 3-292/365
Sequence Identity: 21% (65 aa)

FSKCLGQGGYGSVYRGSL-EDGNQVAVKKLQGSN----------------------QNSRDFYAEVASL----------------ARTNHLNLVKFIGFC
| |..|||..||||...  ....|.| |. .  .                      .. . .  |   .                 . || |..|.. . 
FIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECF

AE-GPRKRLLVYEFVPNGSLEK-----WIFGDDGGDDSSSQQQDGSGGLSWDCKFRIAVGTAQ---------------GLCYLHEECADRIIHLDLKPEN
 |    .  || |..  |.|..     ... .   .      . . . ...    .|    .|               .| |||..    ||| |.||||
QEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIE------K-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN--IIHRDIKPEN

VLVDIGFVPKIADFGLSK----------------------LMNREVTYL-------QMTSMRGTPGYLAPEYLQVGT---------ITEKSDVFSFGVLL
.|.     .||.||||||                       ..|  .|.       .  .  |||||.||| |. .           ..|.|..|.||.|
ILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL

LEIITG
 | ..|
YEMLFG
Kinase IRAK-Un_bd.AA TyrKc 535-824 23 2.9e-33 117.76 SMART 3-280 (280) Show / Hide 
Range on Protein: 535-824
Range on HMM: 3-280/280
Sequence Identity: 23% (75 aa)

FSKCLGQGGYGSVYRGSLEDGNQVAVKKLQGSNQNSRDFYAEVASLART--NHLNLVKFIGFCAEGP------RKRLLVYEFVPNGSLEKWIFGDDGGDD
. | || | .| ||.| .    |||||.|. .    .||. |   . .   .| |.|...| | ..          ..| |..|.|.| . .    .   
LGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK--

SSSQQQDGSGGLSWDCKFRIAVGTAQGLCYLHEECADRIIHLDLKPENVLVDIGFVPKIADFGLSKLMNRE-------VTYLQMT--SMR--GTPGYLAP
           |... .  ...  |.|  |||.    ..|| ||   |.||. ... ||.|||||.    .        .| ...  . .       .||
-----------LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAP

EYLQVGTITEKSDVFSFGVLLLEIITGCRNKY-------MSSDYLRSFSLGGFSRQKSFT--KSISKTRKNLCDGGSSGGIADKYQAAGMARLKAVAYLC
| .. |. |.||||.||||.. || | .   |       || . .. .   |. . .       .|                  .     . .  .   |
ECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYP-MS------------------F-VCCPDEMYQIMKQC

VQDDPDMRPSMSTALKMM
 . ||..||..|.  . .
WHEDPEDRPTFSEIHECF
S_TKc IRAK-Un_bd.AA S_TKc 533-828 22 3.1e-33 117.64 SMART 1-231 (231) Show / Hide 
Range on Protein: 533-828
Range on HMM: 1-231/231
Sequence Identity: 22% (68 aa)

GGFSKCLGQGGYGSVYRGSLED-GNQVAVKKLQGSNQNSRDFYAEVASLARTNHLNLVKFIGFCAEGPRKRLLVYEFVPN--GSLEKWIFGDDGGDDSSS
  . . .|.|..|.||..   . | .||.|..       .... |.. | . .| |.||..... .   .  .| |....  |.| . |           
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYI-----------

QQQDGSGG----LSWDCKFRIAVGTAQGLCYLHEECADRIIHLDLKPENVLVDIGFVPKIADFGLSKLMNREVTYLQMTSMRGTPGYLAPEYLQVGTITE
 .. |..|    ..     ...  ....| |.|.     ||| ||||||.|.|   . ||.||||....         |.. ||| |.||| |     . 
-KKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGK

-KSDVFSFGVLLLEIITGCRNKYMSSDYLRSFSLGGFSRQKSFTKSISKTRKNLCDGGSSGGIADKYQAAGMARLKAVAYLCVQDDPDMRPSMSTALK--
 |.|. |.|..| | ..  .  .   .. . | . |                                      .|     | | ||. ||.   ||.  
CKCDWWSCGCILYEMLC-GYPPFP--QMQMMFKKIG-----------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDE

---MMEGLI
   ..   .
WDIKCHPWF
Kinase IRAK-Un_bd.AA Pkinase_Tyr 535-744 29 4.9e-31 105.74 Pfam 3-212 (270) Show / Hide 
Range on Protein: 535-744
Range on HMM: 3-212/270
Sequence Identity: 29% (65 aa)

FSKCLGQGGYGSVYRGSLE-----DGNQVAVKKL--QGSNQN--SRDFYAEVASLART-NHLNLVKFIGFCA-EGPR-KRLLVYEFVPNGSLEKWIFGDD
| | ||.| .|.||.| .      .. .||||.|  . . ..  ..|| .|.. .    .| |.|...| |  .|   . ..| |..|.|.| .      
FGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHR

GGDDSSSQQQDGSGGLSWDCKFRIAVGTAQGLCYLHEECADRIIHLDLKPENVLVDIGFVPKIADFGLSKLMNREVTY-LQMTSMRGTPGYLAPEYLQVG
          .. . |.   .  ...  |.|. ||..     .|| ||   |.||. ..| ||.||||....  . .|  . .. .     .||| .. |
----------EDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYG

TITEKSDVFSFGVLLLEIITGCR
  |.|||| |||||. ||.| ..
KFTTKSDVWSFGVLMWEIFTYGE
Kinase IRAK-Un_bd.AA STE 535-743 20 1.7e-30 104.99 In-house 1-265 (359) Show / Hide 
Range on Protein: 535-743
Range on HMM: 1-265/359
Sequence Identity: 20% (57 aa)

FSK--CLGQGGYGSVYRGSLED----------------GNQVAVKKLQ--GSN----------------QNSRDFYAEVASLARTN--HLNLVKFIGFCA
. .  ..|.|..|.||..   .                |. .|.|..    .|                ..  ..  |.  . . |  | | ||..| . 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

EGPR------KRLLVYEFVPNGSLEKWIF---GDDGGDDSSSQQQDGSGGLSWDCKFRIAVGTAQG-LCYLHEECADRIIHLDLKPENVLVDIGFVPKIA
 . .      .  .. |....|||.. |    |  .......|    .. .. .   .|.. . .| | |||.     ||| |.|| |.|.      |..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQ--H-QHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLC

DFGLSKLMNREV-------------TYLQMT-SMRGTPGYLAPEYLQV------GTITEKSDVFSFGVLLLEIITGC
|||... .. ..             |  |.. .. ||| . ||| .|       .  ..|.|. |.| ...| .||.
DFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK
Kinase IRAK-Un_bd.AA RIPK 539-742 27 3.7e-30 99.96 In-house 1-224 (290) Show / Hide 
Range on Protein: 539-742
Range on HMM: 1-224/290
Sequence Identity: 27% (66 aa)

LGQGGYGSVYRGSLEDGNQVAVKKL-QGSN-------QNSRDFYAEVASLARTNHLNLVKFIGFCAEG----PRK-RLLVYEFVPNGSLE-----KWIFG
.| || | |..    . . ...||   . .       | . .   |.. ...  . . |.  ||| .     . |   .| |. .||||.     || . 
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPY-

DDGGDDSSSQQQDGSGGLSWDCKFRIAVGTAQGLCYLHEECAD-RIIHLDLKPENVLVDIGFVPKIADFGLSKLMNRE-VTY--------LQMTSMR--G
         |...    . |. ..|. . .. | ||||  . .  |||.||||||.|||  |  |||||||.. |    ..         . |.|    |
---------QHHP----DPWPLRCRMIHEISCGMCYLH--SMNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWG

TPGYLAPEYLQ------VGTITEKSDVFSFGVLLLEIITG
|  |..|| .       .  .|.|.|| ||.... |. |.
TLSYMPPEHFRTDNKKPIKVVTPKYDVYSFAIVMWEVLTQ
Kinase IRAK-Un_bd.AA Ciliate-E2-Unclassified 535-742 22 2e-29 99.25 In-house 3-266 (352) Show / Hide 
Range on Protein: 535-742
Range on HMM: 3-266/352
Sequence Identity: 22% (66 aa)

FSKCLGQGGYGSVYRGSLEDGNQVAVKKLQGSNQNSRDFYAEVA---------------------------SLARTNHLNLVKFIGFCAEGPRKRLLVYE
. |..||||.|.||.   .. .|....|   ..|.  . . .                             .|   .|...||.. .| .   .  .|.|
IIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMF-YCFQDKQNIYIVME

FVPNGSLEKWI----------------------F------GDDGGDDSSSQQQDGSGGLSWDCKF--RIAVGTAQGLCYLHEECADRIIHLDLKPENVLV
....|.|...|                      |      .                      |   ...    |||.|||..    ||| |.||||.|.
YCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKY----------------------KKAKFYFAQILQGLEYLHHKN--NIIHRDIKPENILF

DIG---FVPKIADFGLSK---LMNREVTYLQ-----------MTSMRGTPGYL----APEYLQVGTIT----EKSDVFSFGVLLLEIITG
| .   . .||.|||.||    .| .  . |           |... |||.|.    |||.||         .|.|..|.||.| |...|
DNNGKNYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFG
Kinase IRAK-Un_bd.AA MLK 806-824 31 0.130369 1.52 In-house 273-291 (291) Show / Hide 
Range on Protein: 806-824
Range on HMM: 273-291/291
Sequence Identity: 31% (6 aa)

CVQDDPDMRPSMSTALKMM
| ..||  |||..  ..  
CWNQDPHKRPSFRQIVQHL
Kinase IRAK-Un_bd.AA TKL-Unique 806-824 31 0.229181 0.8 In-house 272-290 (290) Show / Hide 
Range on Protein: 806-824
Range on HMM: 272-290/290
Sequence Identity: 31% (6 aa)

CVQDDPDMRPSMSTALKMM
|  .||. ||| .. ..  
CWHHDPSQRPSFDEIIHRL
Kinase IRAK-Un_bd.AA TKL 859-953 30 9.8e-24 82.35 In-house 82-202 (364) Show / Hide 
Range on Protein: 859-953
Range on HMM: 82-202/364
Sequence Identity: 30% (40 aa)

LNHLNLVKFIG--FCPRK-------------RLPIYEFVPNGSLEKWIFGNDRWIGWLVFKFRIAVGTAQGLCYLHE----ECANK--IIHLDLKLENIL
|.| |.|.|.|  .||..                ..|..|.|||.  .         .  ..|.| ..|.|..|||      |  |  ||| ||| .|||
LRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCT-KPPIIHRDLKSKNIL

VDVGFV--------------PKIADFGLSK
||  .               .||.|||||.
VDENWTNVSNYMYNPNADWCCKICDFGLSR
Kinase IRAK-Un_bd.AA RIPK 904-953 50 8.9e-16 50.21 In-house 109-157 (290) Show / Hide 
Range on Protein: 904-953
Range on HMM: 109-157/290
Sequence Identity: 50% (26 aa)

KFRIAVGTAQGLCYLHEECANK--IIHLDLKLENILVDVGFVPKIADFGLSK
..|. . .. | ||||    ..  |||.|||.||||||  |  |||||||..
RCRMIHEISCGMCYLHS---MNPPIIHRDLKPENILVDNNFHVKIADFGLAT
Kinase IRAK-Un_bd.AA Pkinase 859-955 30 1.4e-14 52.64 Pfam 57-162 (293) Show / Hide 
Range on Protein: 859-955
Range on HMM: 57-162/293
Sequence Identity: 30% (34 aa)

LNHLNLVKFIGFC-PRKRLP-IYEFVPNG----SLEKWIF-GNDRWI--GWLVFKFRIAVGTAQGLCYLHEECANKIIHLDLKLENILVD-VGFVP---K
||| | |......  ....  . |....|    .|  .|   .....   . . || ..  ...|| |.|..   .||| |||.||||.|  | ..   |
LNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKF-YMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVK

IADFGLSKLI
|.||||.|..
ICDFGLAKQF
Kinase IRAK-Un_bd.AA Dicty4 906-955 46 2e-14 44.7 In-house 116-164 (277) Show / Hide 
Range on Protein: 906-955
Range on HMM: 116-164/277
Sequence Identity: 46% (23 aa)

RIAVGTAQGLCYLHEECANKIIHLDLKLENILVDVGFVPKIADFGLSKLI
|.|  .|.|. .||. |   |||.|||  |.|||  .. |..|||||...
RMAFDAARGMNWLHC-CNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYM
Kinase IRAK-Un_bd.AA MLK 859-953 28 1e-13 44.07 In-house 62-181 (291) Show / Hide 
Range on Protein: 859-953
Range on HMM: 62-181/291
Sequence Identity: 28% (34 aa)

LNHLN----LVKFIGFCPRKRLP---IYEFVPNGSLEKWIFG-NDRWIGW-----------LVFKFRIAVGTAQGLCYLHEECANKIIHLDLKLENILVD
|.|.|     ..| | | .   .   . |....|||   . | .. | .            . .....|.  |.|. |||..   .||| |||  |||.|
LSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILID

V------GFVPKIADFGLSK
       . . ||.|||.|.
EICHDMHHGTLKICDFGTSR
Kinase IRAK-Un_bd.AA TKL-Unique 859-957 30 5.5e-13 42.29 In-house 52-169 (290) Show / Hide 
Range on Protein: 859-957
Range on HMM: 52-169/290
Sequence Identity: 30% (37 aa)

LN-HLNLVKFIGFCP------RKRLPIYEFVPNGSLEKWIF---------GNDRWIGWLVFKFRIAVGTAQGLCYLHEECANKIIHLDLKLENILVDVG-
|. | |.|...|.|        ..  . |..| ||| . .           |   . ....  ..|   |||..||| . .  |||.|||  |.||| . 
LHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRV-KMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNS

----FVPKIADFGLSKLIAR
    .  ||.||||||. ..
NIAEWNIKICDFGLSKFNSK
Kinase IRAK-Un_bd.AA Ciliate-E2 913-953 51 2.4e-12 38.65 In-house 171-204 (365) Show / Hide 
Range on Protein: 913-953
Range on HMM: 171-204/365
Sequence Identity: 51% (21 aa)

QGLCYLHEECANKIIHLDLKLENILVDVGFVPKIADFGLSK
..| |||..    ||| |.|.||||.     .||.||||||
LALEYLHSKNN--IIHRDIKPENILF-----IKIIDFGLSK
Kinase IRAK-Un_bd.AA Ciliate-E2-Unclassified 906-955 45 2.2e-11 35.79 In-house 147-197 (352) Show / Hide 
Range on Protein: 906-955
Range on HMM: 147-197/352
Sequence Identity: 45% (24 aa)

RIAVGTAQGLCYLHEECANKIIHLDLKLENILVDVG---FVPKIADFGLSKLI
...    |||.|||..  |.||| |.|.||||.| .   . .||.|||.|| .
FYFAQILQGLEYLHHK--NNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKY
Kinase IRAK-Un_bd.AA IRAK 905-951 50 1.2e-09 30.53 In-house 112-159 (317) Show / Hide 
Range on Protein: 905-951
Range on HMM: 112-159/317
Sequence Identity: 50% (24 aa)

FRIAVGTAQGLCYLHEEC-ANKIIHLDLKLENILVDVGFVPKIADFGL
. |. ||| |. .||.   .  ||| | |  ||| |  |.|||.||||
CSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGL
Kinase IRAK-Un_bd.AA STE 906-953 36 1.5e-09 30.0 In-house 155-195 (359) Show / Hide 
Range on Protein: 906-953
Range on HMM: 155-195/359
Sequence Identity: 36% (18 aa)

RIAVGTAQG-LCYLHEECANKIIHLDLKLENILVDVGFVPKIADFGLSK
.|.. . .| | |||.     ||| |.|  |||.      |..|||...
YICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDFGVCG
Kinase IRAK-Un_bd.AA TK 858-958 13 3e-09 26.35 In-house 99-351 (486) Show / Hide 
Range on Protein: 858-958
Range on HMM: 99-351/486
Sequence Identity: 13% (34 aa)

ALNHLNLVKFIGFCPRKR-----------LPI---YEFVPNGS----LEKWIFGND--------------------------------------------
...| |.|...| | ...            |.    |..|.|.    | ..   ..                                            
LGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQ

------------------------------RWIGWLVFKFRIAVGTAQGLCYLHEE----CANKIIHLDLKLENILVDVGFV-----------PKIADFG
                              . .  .  .  ...  |.|. |||.        ...| ||   |.||. . |            ||||||
DYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFG

LS-----------------------------------------------KLIARW
||                                               ||  ||
LSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRW
Kinase IRAK-Un_bd.AA Pkinase_Tyr 859-955 28 4.7e-07 24.51 Pfam 60-161 (270) Show / Hide 
Range on Protein: 859-955
Range on HMM: 60-161/270
Sequence Identity: 28% (30 aa)

L-NHLNLVKFIGFCPRKRLP-----IYEFVPNGSLEKWIFGN---DRWIGWLVFKFRIAVGTAQGLCYLHEECANKIIHLDLKLENILVDVGFVPKIADF
| .| |.|...| | ... |     . |..|.|.| .    .   .. .     .  ...  |.|. ||..     .|| ||   |.||. ..| ||.||
LGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKD-LLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDF

GLSKLI
||...|
GLARDI
Kinase IRAK-Un_bd.AA IRAK 861-888 40 0.018132 4.76 In-house 62-91 (317) Show / Hide 
Range on Protein: 861-888
Range on HMM: 62-91/317
Sequence Identity: 40% (12 aa)

HLNLVKFIGFCPRKRLP--IYEFVPNGSLE
| |.| . |.|     .  .|.. ||||||
HPNIVPLYGYCTERQCHCLVYPYMPNGSLE