Gene IRAKb_f (S.moellendorffii)

IRAKb_f

Species: S.moellendorffii
Alias: IRAKb_f
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAKb

Sequence

Name Sequence Type Origin Length Description Download
IRAKb_f.AA Protein None 1020 None Fasta, JSON
IRAKb_f.NA RNA None 3063 None Fasta, JSON
IRAKb_f.kin_dom Protein Kinase Domain None 139 None Fasta, JSON

Protein domain

Protein domains of IRAKb_f.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
DUF588 IRAKb_f.AA DUF588 27-188 25 2.9e-29 108.34 Pfam 1-155 (155) Show / Hide 
Range on Protein: 27-188
Range on HMM: 1-155/155
Sequence Identity: 25% (42 aa)

EHEFRISIILLRSFLLVLVIISEALMVTDRETGSVPLPFFGLPRPVFVTKTAKYELVTGLKFYVDALGVVIGYTVLHLLFNIGLVATKGTVVDCKS--VA
.  .||.  .|| . .|. ... ..|.|...| ....         |....||.  .. ... | | ... ||..| |.. . ....|...    .  .|
GRPGRIAELVLRLCAFVFCLAAAWVMGTNKQTKPFFT--------QFIWFWAKFSDYPAFCYFVVANAIACGYSLLQLCLCVYHIMRKRHM-PPRNPGLA

WISFIADSMMGYLLLSSAAVATEIGYLAEEGAPAVLWRKVCNAFGYFCTVYAISVVICFIAALV
|. ||.| .| |||.|.|..|..|.|.. .|  .. | |.|.... ||  .|.|..  |.|...
WFFFIGDQVMAYLLMSAASAAAAITYVWHNGNSHANWMKICWQYHRFCNHVAASIAMSFFAWVC
Kinase IRAKb_f.AA IRAK 788-929 31 1.5e-30 105.53 In-house 1-152 (317) Show / Hide 
Range on Protein: 788-929
Range on HMM: 1-152/317
Sequence Identity: 31% (48 aa)

FSDVNFLAEGGYGSVYRGRLPDGQA--VAVK----QHKLASTQGDKEFCA---EVEVLSCAQQRNLVMLIGYCAEDKKRLLVYEFVCNGSLDSHLYGRR-
|.  | . |||.| ||||.. ....  .|||      ..  .. ...| .   |..|..  .  |.| | |||.|  .  |||..  ||||   | ..  
FHKDNRIGEGGFGCVYRGQW-KNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDG

SKT-VTLEWPARQKIALGAARALRYLHEECRVGCIVHRDMRPNNILLTHDFEP
. .   |.|. | .|..|.|.....||.      | |.|  . ||||  .|.|
QCPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTP
Kinase IRAKb_f.AA TKL 794-928 22 1e-28 100.57 In-house 1-178 (364) Show / Hide 
Range on Protein: 794-928
Range on HMM: 1-178/364
Sequence Identity: 22% (42 aa)

LAEGGYGSVYRGRLPD---------GQAVAVKQHKLASTQGDKE-------------------------FCAEVEVLSCAQ--QRNLVMLIGYCAEDKK-
. .||.| ||.|..           |. ||||. |  . . . .                         |. |.|.... .    |.| ..||| . .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------RLLVYEFVCNGS-LDSHLYGRRSKTVTLEWPARQKIALGAARALRYLHE----ECRVG-CIVHRDMRPNNILLTHDFE
              .|.|.. .|| |. ..           |. | ..||..||.. |||      |.    |.|||  ..|||.  ...
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----------WHQRCRWALDIARGMNYLHSMNPKWCT-KPPIIHRDLKSKNILVDENWT
Kinase IRAKb_f.AA TK 788-926 14 1.7e-21 68.16 In-house 1-276 (486) Show / Hide 
Range on Protein: 788-926
Range on HMM: 1-276/486
Sequence Identity: 14% (40 aa)

FSDVNFLAEGGYG---SVYRGRLPDG--------------------------QAVAVKQHKLASTQGDKE--------------FCAEVEVLSCAQ----
   .. | || .|    ||.|.. ..                          . ||||. |. ... ..|              |..|.|...  .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-QRNLVMLIGYCAEDKK------------RLLVYEFVCNGS----LDSHLYGRRSKTVT-----------------------------------------
   |.| |.|.| ...              ..| |....|.    |...|  .| |. .                                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LEWPARQKIALGAARALRYLHEE-CRVG--CIVHRDMRPNNILLTHD
                               |  . .  ... .|....|||.  |. .   .||||    |.|....
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNCLVGEN
Kinase IRAKb_f.AA TKL-Unique 790-924 28 5e-19 63.88 In-house 1-146 (290) Show / Hide 
Range on Protein: 790-924
Range on HMM: 1-146/290
Sequence Identity: 28% (43 aa)

DVNFLAEGGYGSVYRGRLPDGQAVAVKQHK-LASTQGD--KEFCAEVEVLSCAQ-QRNLVMLIGYCA----EDKKRLLVYEFVCNGSLDSHLY------G
..| . |||||.||.|  . |  ||.|| . ...   .  .||  || .... .   |.| ..|||.      ... .| |..  |||...|        
FWNKIGEGGYGQVYKGKWR-GYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

RRSKTVTLEWPARQKIALGAARALRYLHEECRVGCIVHRDMRPNNILLT
  ..  .| .  | |.|. .|... ||| .     | |||... |.|..
NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP--IIHRDLKSSNFLVD
Kinase IRAKb_f.AA MLK 788-925 23 1.3e-18 61.34 In-house 1-162 (291) Show / Hide 
Range on Protein: 788-925
Range on HMM: 1-162/291
Sequence Identity: 23% (39 aa)

FSDVNFLAEGGYGSVYRGRLPDGQA-----VAVKQHK-------LASTQGDKEFCAEVEVLSCAQQRN----LVMLIGYCAED-KKRLLVYEFVCNGSLD
.    .. .|..|.|..||   ..      ||||...        .... ...|  |.. |.  ...|     . . | |... .. ..| |.. .||| 
IQFHEWIGSGSFGKVWKGRW-RNKDIVAKIVAVKRVRARIFDKSDTYCE-QWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLY

SHLYGRRSKTV----------TLEWPARQKIALGAARALRYLHEECRVGCIVHRDMRPNNILLTH
. |.|.|||            .       ..||  ||.. |||.. ..  |.|||  . |||...
NVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPK-PIIHRDLKSHNILIDE
Kinase IRAKb_f.AA Pkinase 788-929 20 1.1e-16 60.14 Pfam 1-147 (293) Show / Hide 
Range on Protein: 788-929
Range on HMM: 1-147/293
Sequence Identity: 20% (31 aa)

FSDVNFLAEGGYGSVYRGRLPDGQA-VAVKQHKLASTQGDKE--FCA--EVEVLSCAQQRNLVMLIGYCAEDKKRLLVYEFVCNG----SLDSHLYGRRS
.  .  . .|..|.||...  . .  ||||. |. ..  .|.       |....   .  | | |.... ....  .| |.. .|    .| ... ..|.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KTVTLEWPARQKIALGAARALRYLHEECRVGCIVHRDMRPNNILLTHDFEP
.......   .....  .|.| |.|..     |.|||. | |||. .. ..
GCFYFSEWECKFYMYQILRGLEYCHSM----GIIHRDLKPENILIDNNGHI
Kinase IRAKb_f.AA TKL-ciliate2 788-917 31 2.2e-15 47.24 In-house 1-126 (273) Show / Hide 
Range on Protein: 788-917
Range on HMM: 1-126/273
Sequence Identity: 31% (41 aa)

FSDVNFLAEGGYGSVYRGRLPDGQAVAVKQHKLASTQG--DKEFCAEVEVLSCAQQRNLVMLIGYCAEDKKRLLVYEFVCNGSLDSHLYGRRSKTVTLEW
    | ..||||| .|. .  .   ||||. |.   .    ..|  | . .      |.|| .| | .     .. |.   ||| | |    .. | | |
LEIQNKITEGGYGIIYKAKWRE-IVVAVKKFKMDHDNQQQIRDFVNECHAMEALRHPNIVMFLGACTKIPNFCIIMEYCQRGSLWSLL---QNQDVRLTW

PARQKIALGAARALRYLHEECRVGCIVHRDMR
  | .||| .||   |||       |.|||..
EDRRRIALDIARGVHYLH--SSNPPIIHRDLK
Kinase IRAKb_f.AA Pkinase_Tyr 794-927 23 2.4e-15 52.62 Pfam 7-148 (270) Show / Hide 
Range on Protein: 794-927
Range on HMM: 7-148/270
Sequence Identity: 23% (35 aa)

LAEGGYGSVYRGRLP-----DGQAVAVKQHKLASTQGD---KEFCAEVEVLSCA-QQRNLVMLIGYCA-EDKK--RLLVYEFVCNGSLDSHLYGRRSKTV
| || .|.||.|..      ... ||||  |  ... .   ..| .|.....   .  |.| |.| |  ...    ..| |....|.|...|  .|.   
LGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQ

TLEWPARQKIALGAARALRYLHEECRVGCIVHRDMRPNNILLTHDF
 |  .   ....  |... ||..      ..||| .  |.|.|...
PLTMKDLLQMCWQIAKGMEYLESKN----CIHRDLAARNCLVTENN
Kinase IRAKb_f.AA TK-Unique 794-928 22 4.5e-13 41.55 In-house 7-171 (294) Show / Hide 
Range on Protein: 794-928
Range on HMM: 7-171/294
Sequence Identity: 22% (38 aa)

LAEGGYGSVYRGRLPD-------GQAVAVKQHKLASTQGD-KEFCAEVEVLSCAQ-QRNLVMLIGYCAEDK-KRLLVYEFVCNGSLDSHLYGRRSKTVTL
. || .| |.|| .          . ||||..|  .|. | ..|  | ....    . |.|...|.| ..    ....|.. .|.|...|  .| .... 
IGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRPAMRQH

-----------EWPARQK-----------IALGAARALRYLHE-ECRVGCIVHRDMRPNNILLTHDFE
             |...            .| . |... ||..  ...   ||||    |.|||.|..
QTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKI---VHRDLCARNVLLTEDKV
Kinase IRAKb_f.AA TyrKc 788-985 16 1.1e-12 -17.83 SMART 1-280 (280) Show / Hide 
Range on Protein: 788-985
Range on HMM: 1-280/280
Sequence Identity: 16% (48 aa)

FSDVNFLAEGGYGSVYRGRLPDGQAVAVKQHKLASTQGDKEFCAEVEVLSCA--QQRNLVMLIGYCAED-------KKRLLVYEFVCNGSLDSHLYGRRS
 .    | || .| ||.|..   . ||||  |  .    ..|. | ....    .  |.| |.|.| ..       .  ..| |....|.|...|  .| 
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

KTVTLEWPARQKIALGAARALRYLHEECRVGCIVHRDMRPNNILLTHDF-------------EPM-----------------AR------------PFLR
|   | ..   .... .|.  .|||.     ...|||    |.|.....             .                   ..             . .
K---LCMKDLLSFCWQIACGMEYLHSK----NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

----------------------EQKYEK-------------LIDQRLRGRFCVN--------EVENMLLAATLCIDPDPLIRPRMSQVLRLL
                      .| |.              ...|. | .   |          . |    . | . ||  ||..|.. ...
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase IRAKb_f.AA Fer 796-915 29 2.2e-12 38.56 In-house 9-136 (283) Show / Hide 
Range on Protein: 796-915
Range on HMM: 9-136/283
Sequence Identity: 29% (39 aa)

EGGYGSVYRGR-----LP------DGQAVAVKQHKLASTQGD--KEFCAEVEVLSC-AQQRNLVMLIGYCAEDKKRLLVYEFVCNGSLDSHLYGRRSKTV
|| .| ||.||     .       .  ||.|| .| .... .  |||..|  ..    .  | |...|.|. .   ..| ||. .|||||.|    .|  
EGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYLKKNKNK--

TLEWPARQKIALGAARALRYLHEECRVGCIVHRD
|.    . .....||. ..|||. .    ..|||
TVSDNEKIRMCYQAACGMEYLHSKN----CIHRD
Kinase IRAKb_f.AA LISK 793-923 28 4.1e-12 35.44 In-house 1-134 (296) Show / Hide 
Range on Protein: 793-923
Range on HMM: 1-134/296
Sequence Identity: 28% (40 aa)

FLAEGGYGSVYRGRLP-DGQAVAVKQHKL-----ASTQGDKEFCAEVEVLSCAQQRNLVMLIGYCAE-DKKRLLVYEFVCNGSLDSHLYGRRSKTVTLEW
 . .|..|.||.|..  .|| .|.|. .            | .  ||... . . .| |  .| | . |..  .| |..  | |   |  . .. . | |
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW

PARQKIALGAARALRYLHEECRVGCIVHRDMRPNNILL
| | ||||. |....|||.     .|.|||   .|.|.
PQRVKIALDIACGMSYLHSM----NIIHRDLKSKNCLV
Kinase IRAKb_f.AA Dicty5 828-928 27 9.5e-12 36.71 In-house 42-142 (260) Show / Hide 
Range on Protein: 828-928
Range on HMM: 42-142/260
Sequence Identity: 27% (29 aa)

EFCAEVEVLSCAQ--QRNLVMLIGYCAEDKKR-LLVYEFVCNGSLDSHLYGRRS-KTVTLEWPARQKIALGAARALRYLHEECRVGCIVHRDMRPNNILL
||  || ..|  |    |..   |    ..|    | |.. |||| . |  .|      . .. .  .|...|...|.||       |.|||.  .|.|.
EFYREVTIMSIFQSDHPNFIRCYGAHQYNDKYPFHVTEYCHNGSLFNYLNDQRKTTGQPIAYFQQLHMAIDIAQSMRHLHSM----NIIHRDLKSMNFLI

THDFE
| ...
TENWK
Kinase IRAKb_f.AA S_TKc 788-985 16 1.6e-10 -22.61 SMART 1-231 (231) Show / Hide 
Range on Protein: 788-985
Range on HMM: 1-231/231
Sequence Identity: 16% (42 aa)

FSDVNFLAEGGYGSVYRGRLPD-GQAVAVKQHKLASTQGDKEFCAEVEVLSCAQQRNLVMLIGYCAEDKKRLLVYEFVCN--GSLDSHLYGRRSKT--VT
.  .. . .|..|.||..|  . |. ||.|. |       . .. |...|.  .  |.| |.... . ..  .| |.. .  |.| ...  |...   . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LEWPARQKIALGAARALRYLHEECRVGCIVHRDMRPNNILLTH----------------------------DFEP--------------MAR---PFLRE
.     ....   ..|| |.|.      |.|||  | ||||..                             . .              |.    ||   
FPE-HARFYMYQICCALEYCHSHG----IIHRDLKPENILLDEHIKICDFGLARQLTTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEMLCGYPPFP--

QKYEKLIDQRLRGRFCVNEVENMLLAATLCIDPDPLIRPRMSQVLR---------LL
  ....... .         . ..     | . ||  ||   ..|.          .
-QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAKb_f.AA MLK 967-985 36 0.000997 8.96 In-house 273-291 (291) Show / Hide 
Range on Protein: 967-985
Range on HMM: 273-291/291
Sequence Identity: 36% (7 aa)

CIDPDPLIRPRMSQVLRLL
| ..||  || ..|..  |
CWNQDPHKRPSFRQIVQHL
Kinase IRAKb_f.AA TKL 964-985 36 0.018074 4.72 In-house 343-364 (364) Show / Hide 
Range on Protein: 964-985
Range on HMM: 343-364/364
Sequence Identity: 36% (8 aa)

ATLCIDPDPLIRPRMSQVLRLL
.. | |.||  || ....|  |
MQDCWDHDPEKRPSFQEILKRL
Kinase IRAKb_f.AA TK 967-985 42 0.024513 2.78 In-house 468-486 (486) Show / Hide 
Range on Protein: 967-985
Range on HMM: 468-486/486
Sequence Identity: 42% (8 aa)

CIDPDPLIRPRMSQVLRLL
| ..||  ||..||... |
CWHYDPEDRPTFSQLHEQL
Kinase IRAKb_f.AA TKL-Unique 965-985 28 0.03697 3.63 In-house 270-290 (290) Show / Hide 
Range on Protein: 965-985
Range on HMM: 270-290/290
Sequence Identity: 28% (6 aa)

TLCIDPDPLIRPRMSQVLRLL
. | ..|| .||  ....  |
QQCWHHDPSQRPSFDEIIHRL
Kinase IRAKb_f.AA Pkinase_Tyr 965-985 33 0.171172 5.68 Pfam 250-270 (270) Show / Hide 
Range on Protein: 965-985
Range on HMM: 250-270/270
Sequence Identity: 33% (7 aa)

TLCIDPDPLIRPRMSQVLRLL
..| ..||  ||..|.... |
KQCWHYDPEDRPTFSEIHEQL