Gene IRAKf_d-2 (S.moellendorffii)

IRAKf_d-2

Species: S.moellendorffii
Alias: IRAKf_d-2
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAKf

Sequence

Name Sequence Type Origin Length Description Download
IRAKf_d-2.AA Protein None 836 None Fasta, JSON
IRAKf_d-2.NA RNA None 2511 None Fasta, JSON
IRAKf_d-2.kin_dom Protein Kinase Domain None 214 None Fasta, JSON

Protein domain

Protein domains of IRAKf_d-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LRRNT_2 IRAKf_d-2.AA LRRNT_2 27-68 43 7.3e-16 54.44 Pfam 1-46 (46) Show / Hide 
Range on Protein: 27-68
Range on HMM: 1-46/46
Sequence Identity: 43% (20 aa)

LNEEGIALMAFRMQITQ-DP-TGIFTSWNAAD--EDPCGWTGVFCD
.|..| ||.||.  ..  ||  | . |||. .  .|.| |||| ||
HNDDGQALLAFKSSLNDSDPHHGVLSSWNPSSSDSDCCSWTGVTCD
LRR_1 IRAKf_d-2.AA LRR_1 72-94 25 70.41588 0.19 Pfam 1-26 (26) Show / Hide 
Range on Protein: 72-94
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

RVKKLLIHG-A--GLAGTISPA-LSGL
. ..| . |     | |.|.|  . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKf_d-2.AA LRR_1 96-118 33 0.038791 11.75 Pfam 1-26 (26) Show / Hide 
Range on Protein: 96-118
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

FLRTLSLSN-N--LLKGSIPSQ-LSHI
 |..|.||. |   | |.||.  . . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKf_d-2.AA LRR_1 120-142 37 0.033193 11.99 Pfam 1-26 (26) Show / Hide 
Range on Protein: 120-142
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

SLWKLNLSS-N--ELAGTIPAS-IGKI
.| .|.||. |   | |.|| | . . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKf_d-2.AA LRR_1 144-167 51 0.00053 18.36 Pfam 1-26 (26) Show / Hide 
Range on Protein: 144-167
Range on HMM: 1-26/26
Sequence Identity: 51% (14 aa)

GLRMLDLSS-N--LLTGAIPPQLFGNC
 |. ||||. |   ||| |||  | |.
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKf_d-2.AA LRR_1 169-191 29 0.012695 13.47 Pfam 1-26 (26) Show / Hide 
Range on Protein: 169-191
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

KLRFVSLSG-N--ALAGSLPVA-LGSC
.|.  .||| |   | |..|   . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKf_d-2.AA LRR_1 193-215 33 0.008825 14.03 Pfam 1-26 (26) Show / Hide 
Range on Protein: 193-215
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

SLKFVDFSS-N--RLTGSVPAE-IAFL
.|.  |.|. |  .|||..| . .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKf_d-2.AA LRR_1 217-239 25 37.074429 1.18 Pfam 1-26 (26) Show / Hide 
Range on Protein: 217-239
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

ELLLLLIQE-N--SLSGDFPSE-VLYL
 |  | ..  |  .|.|..|..    |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKf_d-2.AA LRR_1 267-289 37 3e-05 22.79 Pfam 1-26 (26) Show / Hide 
Range on Protein: 267-289
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

SLEVLDLSY-N--SFEGPIPSN-FGEC
.|..||||. |  ...| ||.. |  .
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKf_d-2.AA LRR_1 291-313 25 0.073302 10.77 Pfam 1-26 (26) Show / Hide 
Range on Protein: 291-313
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

ELSLINLSH-N--RFS-SPIPDA-IGKL
 |  ..||. |  ... . ||.  . .|
NLQHLDLSGCNCCNLTGH-IPPSCF-NL
LRR_1 IRAKf_d-2.AA LRR_1 315-337 33 0.616812 7.49 Pfam 1-26 (26) Show / Hide 
Range on Protein: 315-337
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

FLVSLDLSS-N--AMHGSIPQA-LTQA
 | .||||. |   . |.||   . . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKf_d-2.AA LRR_1 339-361 40 0.005148 14.86 Pfam 1-26 (26) Show / Hide 
Range on Protein: 339-361
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

FLIELKLSS-N--DFSGTIPRS-LNNL
 | .| ||. |   ..|.|| | . ||
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKf_d-2.AA LRR_1 363-385 33 0.028219 12.24 Pfam 1-26 (26) Show / Hide 
Range on Protein: 363-385
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

YLKTLLLGH-N--MLQGSIPAE-VGRL
 |..| |.. |   |.|.|| .    |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKf_d-2.AA LRR_1 387-409 44 3.8e-05 22.42 Pfam 1-26 (26) Show / Hide 
Range on Protein: 387-409
Range on HMM: 1-26/26
Sequence Identity: 44% (12 aa)

HLERLDLSF-N--NITGSIPIQ-LGDL
.|..||||  |  |.||.||   .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKf_d-2.AA LRR_1 411-435 32 0.75436 7.18 Pfam 1-26 (26) Show / Hide 
Range on Protein: 411-435
Range on HMM: 1-26/26
Sequence Identity: 32% (9 aa)

HLVLFNVSY-N--NLTGFIPRRGVLQRF
.|   ..|. |  |||| || .  .  .
NLQHLDLSGCNCCNLTGHIPPS-CF-NL
Kinase IRAKf_d-2.AA TKL 565-831 23 2.3e-48 166.99 In-house 1-364 (364) Show / Hide 
Range on Protein: 565-831
Range on HMM: 1-364/364
Sequence Identity: 23% (87 aa)

IGYGPLGTVYKAVVDG---------GVALAVKKLSSLG----QITSQ----------------------EAFEREIAILKNVKHRNVVTLEGYYWSPPT-
|| |  |.|||..  |         |   ||||..|       ..||                      . .|.|| .... .| |.| . ||  .||  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------KLLLTEYLPNDSLFHHLHQRMEGQLPLPWWRRFKIALGAARGLAYLHHDCR-----PQVLLFNLKSTNILLDDEFE------------
              . .|| |. ||.|.||          | .|...||..|||..||| .       |...  .||| |||.|. ..            
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD

--PHISDYGLRRLL----PKLDTY----------MTDRKLELAV---GYVAPEMAVQN---------------LRLTDKCDVYSFGVVLLELVTGRRPVQ
  . |.|.|| | .     . ||           ... ..   .   .. |||.  ..               .  . ||||||||.|| |..|..|| .
WCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYY

NLETDAVVLCEYAKAAFEQGRGLQCLDHEMSSFP------------EAEIMQVFRIGLLCTAQDPSRRPSMAAIVQMM
..  . ...   ..  ||.   . |.. .    |            .    .. ..   | ..||. |||.  |.. .
DYPYMPMIF---QDP-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAKf_d-2.AA IRAK 560-831 27 7.6e-35 120.96 In-house 2-317 (317) Show / Hide 
Range on Protein: 560-831
Range on HMM: 2-317/317
Sequence Identity: 27% (89 aa)

DKDCVIGYGPLGTVYKAVVDGGV-ALAVKKL---SSLGQITSQEAFER---EIAILKNVKHRNVVTLEGYYWSPPTKLLLTEYLPNDSLFHHLHQRMEGQ
.|| .|| |  |.||... ..     |||||    .. .. . . |     |. ..    | |.| | ||   ..   |  .|.|| ||.  |. .    
HKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQC

LP--LPWWRRFKIALGAARGLAYLHHDCRPQ--VLLFNLKSTNILLDDEFEPHISDYGLRRLL----PKLDTYMTDRKLELAVG---YVAPEMAVQ--NL
 |  |.| .|..|..|.|.|. .|| . .|   .   . || |||||. |.| |.| || |       |...  |  .  . .|   | .|| .      
PPKPLSWHQRCSICWGTACGIQFLHQN-HPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPE-FIRDPQG

RLTDKCDVYSFGVVLLELVTGRRPVQNLETDAVVLCEYAKAAFEQGRG---LQC-----------------------LDHEMSSFPEAEIMQVFRIGLLC
.|| | ||||||.||||..||.|.| .  .    | ..     |. .     |                        .|| |.. |...    .   . |
QLTKKTDVYSFGIVLLEVLTGCRAVYDDRPEHYYLKDLCEEIMEEWGHLDSCQSTLWVGVATDAWAAPRRMQIYEKFIDHRMPPCPPNMEKEMCQCACCC

TAQDPSRRPSMAAIVQMM
...   ||..||  .| .
GHHRANRRCDMAWVMQQL
Kinase IRAKf_d-2.AA TKL-Unique 564-772 27 1.4e-30 105.14 In-house 4-242 (290) Show / Hide 
Range on Protein: 564-772
Range on HMM: 4-242/290
Sequence Identity: 27% (67 aa)

VIGYGPLGTVYKAVV-DGGVALAVKKLSSLGQITSQEAFEREIAILKNVK-HRNVVTLEGYYW----SPPTKLLLTEYLPNDSLFHHLHQ------RMEG
.|| |  |.|||..     ||. .... ..   .. . ||.|. ..|. . | |.|.. ||      .||   . .||.|  ||  .|||        . 
KIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNN

QLPLPWWRRFKIALGAARGLAYLHHDCRPQVLLFNLKSTNILLDDE-----FEPHISDYGLRRLLPKLDTYMTDRK------LEL-AVGYVAPEMAVQN-
 ..|.. .| |.|. .|.|. ||||   | .. ..|||.|.|.| .     .   |.| ||.... | ..  . ..       ..    ..|||.  .| 
NCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNF

LRLTDKCDVYSFGVVLLELVTGRR------PVQNLETDAV
   . |.||||||.|| |..|. .      | |... ...
CQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQW
Kinase IRAKf_d-2.AA MLK 559-763 26 6.6e-29 97.48 In-house 1-235 (291) Show / Hide 
Range on Protein: 559-763
Range on HMM: 1-235/291
Sequence Identity: 26% (63 aa)

VDKDCVIGYGPLGTVYKAVVDGGV----ALAVKKLSSLG-----QITSQEAFEREIAILKNVKHRN----VVTLEGYYWSPPT-KLLLTEYLPNDSLFHH
 .   .|| |. | |.|..  .       .|||.  .         ..|..||.|. .|. ..|.|    .. . |   .||   ....||... ||.. 
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LHQ-RMEGQ---------LPLPWWRRFKIALGAARGLAYLHHDCRPQVLLFNLKSTNILLDD------EFEPHISDYGLRRLLPKLDTYMTDRKLELAVG
||  | ..             .    ...||  |||..||| . ....  . ||| |||.|.      .    |.| |. | . . .| |....  .|  
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYA--

YVAPEMA--VQNLRLTDKCDVYSFGVVLLELVTGRRP
. |||.    .. . . ||||.|.|||| |..|.. |
WMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVP
Kinase IRAKf_d-2.AA RAF 559-766 25 3.7e-24 74.97 In-house 1-224 (282) Show / Hide 
Range on Protein: 559-766
Range on HMM: 1-224/282
Sequence Identity: 25% (58 aa)

VDKDCVIGYGPLGTVYKAVVDGGVALAVKKLSSLGQITSQE--AFEREIAILKNVKHRNVVTLEGYYWSPP--TKLLLTEYLPNDSLFHHLHQRME-GQL
|.    || |  ||||..   | ||  . ... . .   |    |  |.|..|.  | |..   ||   |   |    |..    ||.||.|      ..
VMVMTRIGSGSFGTVYRGHWHGDVAVKMLNVNDPTPEQMQADVFFKNEVAVYKKTRHCNILLFMGYMSKPQTNTYAIVTQWCEHSSLYHHIHVQETREKF

PLPWWRRFKIALGAARGLAYLHHDCRPQVLLFNLKSTNILLDDEFEPHISDYGLRRLLPKLD--TYMTDRKLELAVGYVAPEMAV-------------QN
 . |   . |..  . |. |||     ...   ||| ||.|...    | |.|| ..  .       .   .   . . ||| .               .
DMHWL--IDISRQVCQGMDYLHAK---NIIHRDLKSNNIFLHEDMTVKIGDFGLMTVKTRWSPRGNQQFEQPTHWILWMAPEVIRNLMIDWRGDVLMQDE

LRLTDKCDVYSFGVVLLELVTGRRPV-QN
.  . . ||||||.|. ||.|.. |  ..
NPYSFQSDVYSFGIVMYELMTRHMPYGCH
Kinase IRAKf_d-2.AA LRRK 559-768 22 6.6e-24 81.45 In-house 1-287 (351) Show / Hide 
Range on Protein: 559-768
Range on HMM: 1-287/351
Sequence Identity: 22% (66 aa)

VDKDCVIGYGPLG-TVYKAVVDG---------------------------GVALAVKKLSSL---------------------------------GQITS
. .   || |  | .||.| . |                           .   |.||.                                    . ...
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

QEAFEREIAILKNVKHRNVVTLEGYYWSPPTKLLLTEYLPNDSLFHHLHQRMEGQL-----PLPWWRRFKIALGAARGLAYLHHDCRPQVLLFNLKSTNI
   | .|..|. . .| |.| | |.  .|..  . .||.|. .| |.|| . . ..      ..|  . ||||  |.|..|| |...| ..  .||| ||
FREFRHEVWIMSHLNHPNIVSLKGFCIHPLC--MVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYL-HSHNPPIIHRDLKSPNI

LL---D---------DEFEPHISDYGLRRLLPKLDTYMTDRKLELAVGYVAPEMAVQN--LRLTDKCDVYSFGVVLLELVTGR-RPVQNLE
||   .         ..   .|.|.|. |.  . ...   ....   |..|||    |     |.| |.||||..| ||.|.. .| ....
LLWSSPQNHSPNYPNAHVCAKIADFGISRMF-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHD
Kinase IRAKf_d-2.AA Dicty4-Unclassified 559-765 27 8.8e-17 53.97 In-house 1-209 (263) Show / Hide 
Range on Protein: 559-765
Range on HMM: 1-209/263
Sequence Identity: 27% (62 aa)

VDKDCVIGYGPLGTVYKAVVDGGVALAVKKLSSLGQITSQ----EAFEREIAILKNVKHRNVVTLEGYYWSP----PTKLLLTEYLPNDSLFHHLH-QRM
.  |  || | .  |.| .   |   ||||. . ..        . | .|..||  . | | |.. ||   |     |    .| ..   ||   | .  
IQIDQFIGKGHFSKVHKGNWK-GKDVAVKKFNE-NKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPS

EGQLPLPWWR--RFKIALGAARGLAYLHHDCRPQVLLFNLKSTNILLDDEFEPHISDYGLRRLLPKLDTYMTDRKLELAVG----YVAPEMAVQNLRLTD
| | |.        |.|.  |.|...||      .    .|| |||.|  |   | | |. |      . ||      ...      .||        . 
EQQQPIKLDDTLIIKYAFDIAQGMQHLHTR---NFIHRDIKSSNILMDKHFNIKIADFGISRVIDFNFN-MT------TIAGTPKWESPEC-LMHESYNQ

KCDVYSFGVVLLELVTGRRPVQ
| ||||....| ||.||  | |
KSDVYSYAMMLYELATGDEPYQ
Kinase IRAKf_d-2.AA TyrKc 559-831 23 2e-16 42.85 SMART 1-280 (280) Show / Hide 
Range on Protein: 559-831
Range on HMM: 1-280/280
Sequence Identity: 23% (70 aa)

VDKDCVIGYGPLGTVYKAVVDGGVALAVKKLSSLGQITSQEAFEREIAILKNV--KHRNVVTLEGYYWSP-------PTKLLLTEYLPNDSLFHHLHQRM
. .. ..| |  |.|||.. .  .  |||.| .      .|.| ||. |....  .| |.| | |.  ..       .  ....|| |. .| ..|. . 
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

EGQLPLPWWRRFKIALGAARGLAYLHHDCRPQVLLFN-----LKSTNILLDDEFEPHISDYGLRRLLPKL-------DTYMTDR--KLE--LAVGYVAPE
.    |..    .... .|.| .|||.         |     |   |.|.....   ||| || | .          |.|..         | .   |||
PK---LCMKDLLSFCWQIACGMEYLHSK--------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE

MAVQNLRLTDKCDVYSFGVVLLELVT-GRRPVQNLETDAVVLCEYAKAAFEQGRGLQCLDH--EMSSFPEAEIMQVFRIGLLCTAQDPSRRPSMAAIVQM
   .  . | | ||.||||.. |. | |  |  . .   ..  . . .  .||. . . ..  .||. ...    ...| . | . ||. ||....|.. 
CI-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSF-VCCPDE-MYQIMKQCWHEDPEDRPTFSEIHEC

M
.
F
Kinase IRAKf_d-2.AA S_TKc 559-834 21 4.9e-16 58.25 SMART 1-231 (231) Show / Hide 
Range on Protein: 559-834
Range on HMM: 1-231/231
Sequence Identity: 21% (63 aa)

VDKDCVIGYGPLGTVYKAVVDG-GVALAVKKLSSLGQITSQEAFEREIAILKNVKHRNVVTLEGYYWSPPTKLLLTEYLPN--DSLFHHLHQRMEGQLP-
 ..  .|| |  |.|||..  . |   |.|...        | ..|||.|||. .| |.|.| ... .     . .||...   .||.....|  . |. 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LPWWRRFKIALGAARGLAYLHHDCRPQVLLFNLKSTNILLDDEFEPHISDYGLRRLLPKLDTYMTDRKLELAVGYVAPEMAVQNLRLTD-KCDVYSFGV
 .|  .  ...   ...|.|.|   . ...   ||  |||||.  .  |.| || |.|         . .     |.|||.       .  |||..|.|.
PFPE-HARFYMYQICCALEYCH--SH-GIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGC

VLLELVTGRRPVQNLETDAVVLCEYAKAAFEQGRGLQCLDHEMSSFPEAEIMQVFRIGLLCTAQDPSRRPSMAAIVQ------MMEML
.| |...|. | .    .  .. .  .                         ..  .   |   ||..||.   . |      ... .
ILYEMLCGYPPFP----QMQMMFKKIG-----------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAKf_d-2.AA DRK 601-707 30 1.9e-15 48.85 In-house 44-146 (258) Show / Hide 
Range on Protein: 601-707
Range on HMM: 44-146/258
Sequence Identity: 30% (33 aa)

FEREIAILKNVKHRNVVTLEGYYWSPPTKLLLTEYLPNDSLFHHLHQRMEGQLPLPWWRRFKIALGAARGLAYLHHDCRPQVLLFNLKSTNILLDDEFEP
| ||| ....  | |..   |    ||  .  .||.|  ||   ||      . . | .. .... .|.|. |||  | | ..   ||| | | |. .  
FHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDE---SIEMDWPLMKQMMFDCAKGMIYLHC-CNPIIIHRDLKSHNLLVDEHWQV

HISDYGL
 ..|.||
KVADFGL
Kinase IRAKf_d-2.AA Pkinase_Tyr 559-675 24 1.1e-13 47.03 Pfam 1-128 (270) Show / Hide 
Range on Protein: 559-675
Range on HMM: 1-128/270
Sequence Identity: 24% (32 aa)

VDKDCVIGYGPLGTVYKAVVD-----GGVALAVKKLSSLGQITS--QEAFEREIAILKNV-KHRNVVTLEGYYW--SPP-TKLLLTEYLPNDSLFHHLHQ
. .. ..| |  |.|||.. .     ...  |||.|          .|.| ||..|.|.  .| |.| | |     . |   .. .|| |. .| ..|..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

R-MEGQLPLPWWRRFKIALGAARGLAYLH
. ...| . . .   ....  |.|..||.
HREDKQPLTMKD-LLQMCWQIAKGMEYLE
Kinase IRAKf_d-2.AA TK 559-675 11 1.1e-13 41.48 In-house 1-251 (486) Show / Hide 
Range on Protein: 559-675
Range on HMM: 1-251/486
Sequence Identity: 11% (28 aa)

VDKDCVIGYGPLG---TVYKAVVDGG----------------------------VALAVKKLSSLGQITSQEA--------------FEREIAILKN--V
.    ..| |  |   .|||. . |.                            || ...|. .  . . ...              . .|......   
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

KHRNVVTLEGYYWSPPTK------------LLLTEYLPNDS----LFHHLHQRMEGQLP-----------------------------------------
.| |.| | |.   . .|            ....|| |. .    | ..|... ..  .                                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LPWWRRFKIALGAARGLAYLH
                               |.  ..  ... .|.|..|||
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLH
Kinase IRAKf_d-2.AA Dicty4 559-707 30 1.3e-13 41.98 In-house 1-160 (277) Show / Hide 
Range on Protein: 559-707
Range on HMM: 1-160/277
Sequence Identity: 30% (49 aa)

VDKDCVIGYGPLGTVYKAVVDGGVALAVKKLSSLGQITSQ---EAFEREIAILKNVKHRNVVTLEGYYW----SPPTKLLLTEYLPNDSLFHHLHQ----
 ...  || | .|.|||. .  | . ||||| .. |  ..   ..| .|..|...  | |.... |.       |.. .  |||.|  .|.  ||     
INIEQRIGKGSFGEVYKGTW-RGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSE

-RMEGQLPLPWWRR-FKIALGAARGLAYLHHDCRPQVLLFNLKSTNILLDDEFEPHISDYGL
   . .|..|  .|  ..|. ||||...||  | | ..   ||| |.| |. .   ..| ||
QQQSIKLDWPLIKRAMRMAFDAARGMNWLHC-CNPVIIHRDLKSHNLLVDKNWRVKVCDFGL
Kinase IRAKf_d-2.AA TK 691-831 15 5.1e-12 35.82 In-house 270-486 (486) Show / Hide 
Range on Protein: 691-831
Range on HMM: 270-486/486
Sequence Identity: 15% (34 aa)

NILLDDEFE-----------PHISDYGLR--------RLLPKLDTYMTDR------------------------KLELAVGYVAPEMAVQNL--------
|.|....               |.|.||         | ... | | ...                        .  | . . |||    .         
NCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYG

RLTDKCDVYSFGVVLLELVT-GRRPVQNLETD--------AVVLCEYAKAAF--------EQGRGLQCLD-HEMSSFP-------EAEIMQVFRIGLLCT
. | | ||.||||.. |..| |. |     ..           ..|| ..          |.|.....     .....       ...   .... . | 
KFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCW

AQDPSRRPSMAAIVQMM
. ||..||.........
HYDPEDRPTFSQLHEQL
Kinase IRAKf_d-2.AA Pkinase 559-675 24 9.5e-12 42.63 Pfam 1-125 (293) Show / Hide 
Range on Protein: 559-675
Range on HMM: 1-125/293
Sequence Identity: 24% (31 aa)

VDKDCVIGYGPLGTVYKAVVDGGVA-LAVKKLSSLGQITSQ-EAFER--EIAILKNVKHRNVVTLEGYYWSPPTKLLLTEYLPND----SLFHHLHQRME
  .  .|| |  |.|||..  |     |||...  ..  .. ..  |  ||.|.|...| |.|.| ... ...   . .||....    .||.... ...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GQLPLPWWRRFKIALGAARGLAYLH
| . ...|   ....  .|||.|.|
GCFYFSEWECKFYMYQILRGLEYCH
Kinase IRAKf_d-2.AA Pkinase 687-766 28 4e-06 22.57 Pfam 134-214 (293) Show / Hide 
Range on Protein: 687-766
Range on HMM: 134-214/293
Sequence Identity: 28% (25 aa)

LKSTNILLDDEFEP----HISDYGLRRLLPKLDTYMTDRKLELAVG---YVAPEMAVQ-NLRLTDKCDVYSFGVVLLELVTGRRPVQN
||. |||.|.. ..    .|.| || ...     |  .. .   .|   |.|||  .. .   . |.|..|.|..| |...|| | ..
LKPENILIDNNGHIDACVKICDFGLAKQFD----Y-NNS-MTTFCGTPWYMAPEV-IRGGQYYGPKVDMWSCGCILYEMLCGRPPFPG
Kinase IRAKf_d-2.AA Dicty4 727-763 40 4e-06 16.6 In-house 181-216 (277) Show / Hide 
Range on Protein: 727-763
Range on HMM: 181-216/277
Sequence Identity: 40% (15 aa)

VGYVAPEMAVQNLRLTDKCDVYSFGVVLLELVTGRRP
....|||.  .. . . | |||||| || |..|.  |
PCWMAPEV-MMHQPYNEKADVYSFGIVLWEILTRQEP
Kinase IRAKf_d-2.AA DRK 728-759 53 3.1e-05 13.7 In-house 167-197 (258) Show / Hide 
Range on Protein: 728-759
Range on HMM: 167-197/258
Sequence Identity: 53% (17 aa)

GYVAPEMAVQNLRLTDKCDVYSFGVVLLELVT
. .|||    | | | | |||||..|| |.||
CWTAPEV-LRNQRYTEKADVYSFAIVLWECVT
Kinase IRAKf_d-2.AA LRRK 812-833 31 5.6e-05 13.53 In-house 330-351 (351) Show / Hide 
Range on Protein: 812-833
Range on HMM: 330-351/351
Sequence Identity: 31% (7 aa)

LCTAQDPSRRPSMAAIVQMMEM
.| ..|| .||..  ||. .. 
HCWQHDPKKRPHFSQIVKRLSQ
Kinase IRAKf_d-2.AA Dicty4 817-833 42 0.000159 11.2 In-house 259-277 (277) Show / Hide 
Range on Protein: 817-833
Range on HMM: 259-277/277
Sequence Identity: 42% (8 aa)

DPSRRPSMAAIVQM--MEM
||..|||.. |.|   .| 
DPQHRPSFEEIIQRRILEH
Kinase IRAKf_d-2.AA DRK 813-833 38 0.000233 10.71 In-house 238-258 (258) Show / Hide 
Range on Protein: 813-833
Range on HMM: 238-258/258
Sequence Identity: 38% (8 aa)

CTAQDPSRRPSMAAIVQMMEM
|   ||. ||||  ... .| 
CWNEDPQHRPSMQECLERLEA
Kinase IRAKf_d-2.AA Pkinase_Tyr 691-763 33 0.000374 14.69 Pfam 141-214 (270) Show / Hide 
Range on Protein: 691-763
Range on HMM: 141-214/270
Sequence Identity: 33% (25 aa)

NILLDDEFEPHISDYGLRRLLPKLDTY-MTDRKLELAVGYVAPEMAVQNLRLTDKCDVYSFGVVLLELVT-GRRP
|.|.....   |.| || |.. . |.|  .  .  | .   ||| . .. . | | ||.||||.. |..| |. |
NCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPE-CINYGKFTTKSDVWSFGVLMWEIFTYGEQP
Kinase IRAKf_d-2.AA Dicty4-Unclassified 813-831 42 0.001428 8.06 In-house 245-263 (263) Show / Hide 
Range on Protein: 813-831
Range on HMM: 245-263/263
Sequence Identity: 42% (8 aa)

CTAQDPSRRPSMAAIVQMM
|   || .||.|  |.| .
CWHNDPNKRPTMNQIIQYL
Kinase IRAKf_d-2.AA MLK 816-831 56 0.002882 7.34 In-house 276-291 (291) Show / Hide 
Range on Protein: 816-831
Range on HMM: 276-291/291
Sequence Identity: 56% (9 aa)

QDPSRRPSMAAIVQMM
|||..|||.. |||  
QDPHKRPSFRQIVQHL
Kinase IRAKf_d-2.AA Pkinase_Tyr 811-831 28 0.012578 9.52 Pfam 250-270 (270) Show / Hide 
Range on Protein: 811-831
Range on HMM: 250-270/270
Sequence Identity: 28% (6 aa)

LLCTAQDPSRRPSMAAIVQMM
..| ..||..||....|....
KQCWHYDPEDRPTFSEIHEQL
Kinase IRAKf_d-2.AA RAF 813-833 19 0.018039 3.48 In-house 262-282 (282) Show / Hide 
Range on Protein: 813-833
Range on HMM: 262-282/282
Sequence Identity: 19% (4 aa)

CTAQDPSRRPSMAAIVQMMEM
| . ..  ||.   |......
CWKFQREERPLFQQILKRITV
Kinase IRAKf_d-2.AA TKL-Unique 813-831 42 0.028019 4.06 In-house 272-290 (290) Show / Hide 
Range on Protein: 813-831
Range on HMM: 272-290/290
Sequence Identity: 42% (8 aa)

CTAQDPSRRPSMAAIVQMM
| ..||| |||   |.   
CWHHDPSQRPSFDEIIHRL
Kinase IRAKf_d-2.AA Pkinase 815-831 31 5.543657 1.02 Pfam 275-293 (293) Show / Hide 
Range on Protein: 815-831
Range on HMM: 275-293/293
Sequence Identity: 31% (6 aa)

AQDPSRRPSMAAIVQM--M
..||..||. . |.|   .
CKDPKKRPTAEQILQHPWF