Gene IRAKf_g (S.moellendorffii)

IRAKf_g

Species: S.moellendorffii
Alias: IRAKf_g
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAKf

Sequence

Name Sequence Type Origin Length Description Download
IRAKf_g.AA Protein None 554 None Fasta, JSON
IRAKf_g.NA RNA None 1665 None Fasta, JSON
IRAKf_g.kin_dom Protein Kinase Domain None 202 None Fasta, JSON

Protein domain

Protein domains of IRAKf_g.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LRRNT_2 IRAKf_g.AA LRRNT_2 1-38 52 4.4e-13 45.4 Pfam 5-46 (46) Show / Hide 
Range on Protein: 1-38
Range on HMM: 5-46/46
Sequence Identity: 52% (22 aa)

GQALLAFKASLND-SA-GALLLDWIESD--SHPCRWTGVSCH
||||||||.|||| .  .  |..|  |.  | .|.||||.| 
GQALLAFKSSLNDSDPHHGVLSSWNPSSSDSDCCSWTGVTCD
LRR_1 IRAKf_g.AA LRR_1 43-65 25 2.676056 5.23 Pfam 1-26 (26) Show / Hide 
Range on Protein: 43-65
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

KVKSLNLPYR---RLVGTISPE-LGKL
. ..|.| .    .|.|.|.|. . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKf_g.AA LRR_1 67-89 29 0.094429 10.38 Pfam 1-26 (26) Show / Hide 
Range on Protein: 67-89
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

RLARLALHH-N--SFYGTIPSE-LGNC
.| .| | . |  .. |.||.. . |.
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKf_g.AA LRR_1 91-113 37 0.008999 14.0 Pfam 1-26 (26) Show / Hide 
Range on Protein: 91-113
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

RLRALYLKN-N--YLGGTIPKE-FGRL
.|. |.| . |   | |.||.. |  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKf_g.AA LRR_1 115-137 37 0.000434 18.67 Pfam 1-26 (26) Show / Hide 
Range on Protein: 115-137
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

SLRILDVSS-N--SLTGSVPDV-LGDL
.|..||.|. |  .|||..|.  .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKf_g.AA LRR_1 139-163 32 0.61282 7.5 Pfam 1-26 (26) Show / Hide 
Range on Protein: 139-163
Range on HMM: 1-26/26
Sequence Identity: 32% (9 aa)

QLVFLNVST-N--ALIGEIPSNGVLSNF
.|  |..|  |   | |.||..  . |.
NLQHLDLSGCNCCNLTGHIPPS-CF-NL
Kinase IRAKf_g.AA TKL 271-535 21 1.6e-64 220.69 In-house 1-364 (364) Show / Hide 
Range on Protein: 271-535
Range on HMM: 1-364/364
Sequence Identity: 21% (83 aa)

IGCGGFGTVYKLVMDD---------GNMFAVKRIAKGGFGSE---------------------------RLFERELEILGSIKHRNLVNLRGYCNSGSA-
|| ||||.||| .            |.  |||.. .    ..                             .|.|. .. ...| |.| . |||....  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------RLLIYDFLSHGSLDDLLHEREPHKPSLNWNHRMKAAIGSARGISYLHHDCS-----PRIVHRDIKSSNILLDSNFE------------
              ..... ..||| ..||          |..|.. |.. |||..||| .       | |.|||.||.|||.|.|..            
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD

--PHVSDFGLAKLLNE------------------NQSHMTTIVAGTFGYLAPEYMQ----------------SGRVTEKSDVYSFGVVLLELLSGKRPTD
  . ..||||.. ...                  |.. .|  . ||....||| ..                ..  .||.||||||.|| |.|...|   
WCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR---

PGFVAKGLNVVGWVNALIKENKQK------EVFDSKCEGGSRESME--------------C---VLQIAAMCIAPLPDDRPTMDNVVKML
             . . .... ..      | |   |. | |  .               |   . ... .| .. |..||... ..| |
-------------PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAKf_g.AA IRAK 267-535 28 5.8e-61 208.84 In-house 3-317 (317) Show / Hide 
Range on Protein: 267-535
Range on HMM: 3-317/317
Sequence Identity: 28% (92 aa)

ENDIIGCGGFGTVYKLVMDDGN-MFAVKRIAKGGF----GSERLFER---ELEILGSIKHRNLVNLRGYCNSGSARLLIYDFLSHGSLDDLLHEREPHKP
..  || ||||.||. ...     .|||.. ..      .... |     ||... .. | |.| | |||  ..   |.|.... ||| | |. . .  |
KDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQCP

--SLNWNHRMKAAIGSARGISYLHHDCSP-RIVHRDIKSSNILLDSNFEPHVSDFGLAKL-----LNENQSH---MTTIVAGTFGYLAPEYMQ--SGRVT
   | |  | . ..|.|.|| .|| . .   | |.||||.||||| .|.|  .||||.        .| |.    || .| ||  |..||..   .|. |
PKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQLT

EKSDVYSFGVVLLELLSGKRPTDPGFVAKGLNVVGWVNALIKENKQKEV------------------------------FDSKCEGGSRESMECVLQIAA
 |.||||||.||||.|.| |.     | .    .     |. |.....                                |.. ..  ... .  .| | 
KKTDVYSFGIVLLEVLTGCRA-----VYDDRPEHYYLKDLCEEIMEEWGHLDSCQSTLWVGVATDAWAAPRRMQIYEKFIDHRMPPCPPNMEKEMCQCAC

MCIAPLPDDRPTMDNVVKML
 | .     |..|. |.. |
CCGHHRANRRCDMAWVMQQL
Kinase IRAKf_g.AA TKL-Unique 269-466 32 2.4e-44 153.67 In-house 3-233 (290) Show / Hide 
Range on Protein: 269-466
Range on HMM: 3-233/290
Sequence Identity: 32% (75 aa)

DIIGCGGFGTVYKLVMDDGNMFAVKRIAK---GGFGSERLFERELEILGSIK-HRNLVNLRGYCN----SGSARLLIYDFLSHGSLDDLLH------ERE
  || ||.|.||| ..  |   |.|....     . ... ||.|. ..  .. | |.| . |||     . . . .. .....|||.|.||         
NKIGEGGYGQVYK-GKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNN

PHKPSLNWNHRMKAAIGSARGISYLHHDCSPRIVHRDIKSSNILLDSN-----FEPHVSDFGLAKLLN-ENQSHMTTI-------VAGTFGYLAPEYMQS
. .  ||.. |.| ||  |.|  ||||   | | |||.||||.|.|.|     .   ..||||.|... .|..  ...       . |.| ..||| . .
NNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRM

--GRVTEKSDVYSFGVVLLELLSGKR------P
     .|||||||||.|| |....|.      |
NFCQYSEKSDVYSFGIVLWEIATRKITKTYKKP
Pkinase IRAKf_g.AA Pkinase 265-464 29 7.2e-42 149.13 Pfam 1-209 (293) Show / Hide 
Range on Protein: 265-464
Range on HMM: 1-209/293
Sequence Identity: 29% (64 aa)

LGENDIIGCGGFGTVYKLVMDDGNM-FAVKRIAKGGFGSERL--FER--ELEILGSIKHRNLVNLRGYCNSGSARLLIYDFLSHG----SLDDLLH-ERE
.    .|| |.||.||| .  . .  .|||.| | .  |. .    |  |..|. ...| | | |.... ...   .. ... .|    .| |... .|.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

PHKPSLNWNHRMKAAIGSARGISYLHHDCSPRIVHRDIKSSNILLDSNFEP----HVSDFGLAKLL-NENQSHMTTIVAGTFGYLAPEYMQ-SGRVTEKS
     . ...  . .   .||. |.|     .|.|||.|..|||.|.| ..    ...||||||.. . |.| |||.. || .|.|||  . .   . |.
GCFY-FSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFC-GTPWYMAPEVIRGGQYYGPKV

DVYSFGVVLLELLSGK
|..|.|..| |.|.|.
DMWSCGCILYEMLCGR
Kinase IRAKf_g.AA MLK 265-466 27 3.1e-39 133.79 In-house 1-235 (291) Show / Hide 
Range on Protein: 265-466
Range on HMM: 1-235/291
Sequence Identity: 27% (64 aa)

LGENDIIGCGGFGTVYKLVMDDGN----MFAVKRIA---KGGFGSE----RLFERELEILGSIKHRN----LVNLRGYCNS-GSARLLIYDFLSHGSLDD
. .  .|| |.|| |.| ..   .      ||||..       ...    . ||.| ..|  ..|.|     . ..| |.. ..  ...  ....||| .
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

LLHEREPHKP----------SLNWNHRMKAAIGSARGISYLHHDCSPRIVHRDIKSSNILLDS------NFEPHVSDFGLAKLLNENQSHMTTIVAGTFG
.||.....                 | |. |   |||..||| .  . |.|||.||.|||.|       .    ..|||... .....    .  |||. 
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYA

YLAPEYM---QSGRVTEKSDVYSFGVVLLELLSGKRP
. |||     ......||.||.|.|||| |.|... |
WMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVP
Kinase IRAKf_g.AA S_TKc 265-540 24 6.1e-38 133.29 SMART 1-231 (231) Show / Hide 
Range on Protein: 265-540
Range on HMM: 1-231/231
Sequence Identity: 24% (69 aa)

LGENDIIGCGGFGTVYKLVMDD-GNMFAVKRIAKGGFGSERLFERELEILGSIKHRNLVNLRGYCNSGSARLLIYDFLSH--GSLDDLLHEREPHKPS--
    ..|| |.||.||| .  . |  .|.|.|        . ..||..|| . .| |.|.| ... . .   .. .....  |.| |....| .|..   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LNWNHRMKAAIGSARGISYLHHDCSPRIVHRDIKSSNILLDSNFEPHVSDFGLAKLLNENQSHMTTIVAGTFGYLAPEYMQSGRVTE-KSDVYSFGVVLL
..  |  . .   .... |.|   | .|.|||.| .|||||.  .  ..|||||..|        | . ||  |.||| .     .  |.|..|.|..| 
FPE-HARFYMYQICCALEYCH---SHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

ELLSGKRPTDPGFVAKGLNVVGWVNALIKENKQKEVFDSKCEGGSRESMECVLQIAAMCIAPLPDDRPTMDNVVK----MLESEMM
|.|.|. | .   ... ....|                         | |.   .   |    |..|||   . .        . .
EMLCGYPPFP--QMQMMFKKIG-------------------------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAKf_g.AA LRRK 265-466 23 9.3e-37 127.56 In-house 1-282 (351) Show / Hide 
Range on Protein: 265-466
Range on HMM: 1-282/351
Sequence Identity: 23% (68 aa)

LGENDIIGCGGFG-TVYKLVMDD---------------------------GNMFAVKRIAKGG----------------------------------FGS
| ..  || |||| .||.  . .                           ... |.| . ...                                    .
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

ERLFERELEILGSIKHRNLVNLRGYCNSGSARLLIYDFLSHGSLDDLLHEREPHK-----PSLNWNHRMKAAIGSARGISYLHHDCSPRIVHRDIKSSNI
 |.| .|. |. . .| |.|.| |.|   . . .. ....||.|...||... ..     ....|. . | |.  |.|. || |...| |.||| || ||
FREFRHEVWIMSHLNHPNIVSLKGFCI--HPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYL-HSHNPPIIHRDLKSPNI

LLDSNFEP------------HVSDFGLAKLLNENQSHMTTIVAGTFGYLAPEYMQSG---RVTEKSDVYSFGVVLLELLSGK-RP
|| |  ..            ...|||.  .    ..  .  . |..|..||| |. .     |||.|.||||..| |||... .|
LLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHP
Kinase IRAKf_g.AA Dicty4 306-461 35 4.5e-35 114.55 In-house 45-211 (277) Show / Hide 
Range on Protein: 306-461
Range on HMM: 45-211/277
Sequence Identity: 35% (60 aa)

FERELEILGSIKHRNLVNLRGYCN---SGSARLLI-YDFLSHGSLDDLLHE-----REPHKPSLNWNHR-MKAAIGSARGISYLHHDCSPRIVHRDIKSS
| .| .|...| | |.. . |.|.   | . ...|   ... |.|  |||       .  |...    | |. |.  |||. .||  | |.|.|||.||.
FRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHC-CNPVIIHRDLKSH

NILLDSNFEPHVSDFGLAKLLNENQSHMT--TIVAGTFGYLAPEYMQSGRVTEKSDVYSFGVVLLELL
|.| | |.   |.||||...  .  .| .  . ..|| .. ||| |.. . .||.|||||| || |.|
NLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADVYSFGIVLWEIL
Kinase IRAKf_g.AA Dicty4-Unclassified 306-466 38 7.1e-35 116.86 In-house 45-207 (263) Show / Hide 
Range on Protein: 306-466
Range on HMM: 45-207/263
Sequence Identity: 38% (65 aa)

FERELEILGSIKHRNLVNLRGYCNSG----SARLLIYDFLSHGSLDDLLH--EREPHKP-SLNWNHRMKAAIGSARGISYLHHDCSPRIVHRDIKSSNIL
| .| |||||| | ||| ..|||       |    .  |.  | |  . |    |  .| .|.    .| |.  |.|. .||   .  ..||||||||||
FKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQPIKLDDTLIIKYAFDIAQGMQHLH---TRNFIHRDIKSSNIL

LDSNFEPHVSDFGLAKLLNENQSHMTTIVAGTFGYLAPEYMQSGRVTEKSDVYSFGVVLLELLSGKRP
.| .|   . |||..     |.  |||| |||    .|| .     . ||||||....| ||. |  |
MDKHFNIKIADFGISRVIDFNFN-MTTI-AGTPKWESPECLMHESYNQKSDVYSYAMMLYELATGDEP
Kinase IRAKf_g.AA TyrKc 265-535 23 2.4e-32 114.69 SMART 1-280 (280) Show / Hide 
Range on Protein: 265-535
Range on HMM: 1-280/280
Sequence Identity: 23% (70 aa)

LGENDIIGCGGFGTVYKLVMDDGNMFAVKRIAKGGFGSERLFERELEILGSI--KHRNLVNLRGYCNSG-------SARLLIYDFLSHGSLDDLLHEREP
.  ....|.| ||.||| ...   . ||| . ..    .. | ||..|. ..  .| |.|.| |.| ..          ...  . .||.|.| |....|
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

HKPSLNWNHRMKAAIGSARGISYLHHDCSPRIVHRDIKSSNILLDSNFEPHVSDFGLAKLLNEN------QSHMTT----IVA--GTFGYLAPEYMQSGR
.   |.. .  . ..  |.| .|||.    ...|||.   |.|...|.   .|||||.. . .       ..  ..              .||| .. |.
K---LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

VTEKSDVYSFGVVLLELLS-GKRPTDP---GFVAKGLNVVGWVNALIKENKQKE----VFDSKCEGGSRESMECVLQIAAMCIAPLPDDRPTMDNVVKML
 |.||||.||||.. |... |. |        . .   |. .| .     . ..     |        . . |    |  .| .  |.||||. .... .
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSF-------VCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHECF
Kinase IRAKf_g.AA DRK 306-461 33 8.9e-31 101.48 In-house 44-196 (258) Show / Hide 
Range on Protein: 306-461
Range on HMM: 44-196/258
Sequence Identity: 33% (53 aa)

FERELEILGSIKHRNLVNLRGYCNSGSARLLIYDFLSHGSLDDLLHEREPHKPSLNWNHRMKAAIGSARGISYLHHDCSPRIVHRDIKSSNILLDSNFEP
| || ...    | | .   | ||  .  . .  ... |||   ||.    . .. |  ... ..  |.|. |||  | | |.||| || | | | ..  
FHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHD---ESIEMDWPLMKQMMFDCAKGMIYLHC-CNPIIIHRDLKSHNLLVDEHWQV

HVSDFGLAKLLNENQSHMTTIVA-GTFGYLAPEYMQSGRVTEKSDVYSFGVVLLELL
 |.||||.      ..| ..  . || .  |||   . | ||| |||||..|| |..
KVADFGLSTRFKKHKQHKFAMTMCGTPCWTAPEVLRNQRYTEKADVYSFAIVLWECV
Kinase IRAKf_g.AA STE 266-466 21 1.1e-30 105.56 In-house 1-267 (359) Show / Hide 
Range on Protein: 266-466
Range on HMM: 1-267/359
Sequence Identity: 21% (58 aa)

GEN-DIIGCGGFGTVYKLVMDD----------------GNMFAVKRIAKGGFGS-----------------ERLFERELEILGSIK--HRNLVNLRGYCN
 |. ..|| |.|||||| .  .                |...|.|.. .    .                 .  ...|..|.   .  | | |.  |.. 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

SG-------SARLLIYDFLSHGSLDDLLHEREPHKPSLN----------WNHRMKAAIGSARG-ISYLHHDCSPRIVHRDIKSSNILLDSNFEPHVSDFG
 .       .   ..  ... |||||.....  .. .||           .   . .    .|  .|||      |.|||||..||||        .|||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDFG

LAKLLNE---------------NQSHMTTIVAGTFGYLAPEYMQSGR------VTEKSDVYSFGVVLLELLSGKRP
... |..               ... ... ..||  . ||| .| ..       ..|.|..|.| ...|.. || |
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPP
Kinase IRAKf_g.AA TK 265-466 16 1.3e-30 99.2 In-house 1-394 (486) Show / Hide 
Range on Protein: 265-466
Range on HMM: 1-394/486
Sequence Identity: 16% (65 aa)

LGENDIIGCGGFG---TVYKLVMDDGN--------------------------MFAVKRIAKG-GFGSERLFE-------------RELEILGSIK----
.   . .| | ||   .|||  . ..|                            ||| . .| .  .|. |.             .|.|..   .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HRNLVNLRGYCNSG------------SARLLIYDFLSHGS----LDDLLHEREPHKPS-----------------------------------------
 | |.|.| |.|  |               ...  . .||.    |.| |... |..                                           
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LNWNHRMKAAIGSARGISYLHHD----CSPRIVHRDIKSSNILLDSNFE-----------PHVSDFG--
                               |.  ...  .   |.| .|||        ...||||.   |.|...|               ..|||  
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

------LAKLLNENQSHMTTIVAGTFG-------------------------YLAPEYMQ---------SGRVTEKSDVYSFGVVLLELLS-GKRP
      ||. .....   ..   || .                         ..||| ..          |. |.||||.||||.. |... |. |
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEP
Kinase IRAKf_g.AA Pkinase_Tyr 265-466 28 1.7e-27 93.73 Pfam 1-214 (270) Show / Hide 
Range on Protein: 265-466
Range on HMM: 1-214/270
Sequence Identity: 28% (63 aa)

LGENDIIGCGGFGTVYKLVMD-----DGNMFAVKRIAKGGFGSE----RLFERELEILGSI-KHRNLVNLRGYCN-SGSA--RLLIYDFLSHGSLDDLLH
.  .  .| | ||.||| ...     ..   ||| . | |  .|    . | ||..|. .. .| |.|.| | |   |     ...  .  ||.|.| |.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

EREPHKPSLNWNHRMKAAIGSARGISYLHHDCSPRIVHRDIKSSNILLDSNFEPHVSDFGLAKLL-NENQS-HMTTIVAGTFGYLAPEYMQSGRVTEKSD
.. . |..|.  .  . ..  |.| .||.      ..|||.   |.|...|.   ..|||||... |. .  ....        .||| .. |. |.|||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSD

VYSFGVVLLELLS-GKRP
|.||||.. |... |. |
VWSFGVLMWEIFTYGEQP
Kinase IRAKf_g.AA TK 512-535 29 0.000326 9.18 In-house 463-486 (486) Show / Hide 
Range on Protein: 512-535
Range on HMM: 463-486/486
Sequence Identity: 29% (7 aa)

QIAAMCIAPLPDDRPTMDNVVKML
..  .| .. |.||||.. ....|
DLMQQCWHYDPEDRPTFSQLHEQL
Kinase IRAKf_g.AA TKL-Unique 516-535 30 0.000382 10.72 In-house 271-290 (290) Show / Hide 
Range on Protein: 516-535
Range on HMM: 271-290/290
Sequence Identity: 30% (6 aa)

MCIAPLPDDRPTMDNVVKML
.| .. |..||. |.... |
QCWHHDPSQRPSFDEIIHRL
Kinase IRAKf_g.AA DRK 522-537 37 0.000605 9.29 In-house 243-258 (258) Show / Hide 
Range on Protein: 522-537
Range on HMM: 243-258/258
Sequence Identity: 37% (6 aa)

PDDRPTMDNVVKMLES
|  ||.|. ... ||.
PQHRPSMQECLERLEA
Kinase IRAKf_g.AA MLK 516-535 30 0.019257 4.44 In-house 272-291 (291) Show / Hide 
Range on Protein: 516-535
Range on HMM: 272-291/291
Sequence Identity: 30% (6 aa)

MCIAPLPDDRPTMDNVVKML
.|  . | .||... .|. |
QCWNQDPHKRPSFRQIVQHL
Kinase IRAKf_g.AA Dicty4 265-281 47 0.026228 3.7 In-house 1-17 (277) Show / Hide 
Range on Protein: 265-281
Range on HMM: 1-17/277
Sequence Identity: 47% (8 aa)

LGENDIIGCGGFGTVYK
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INIEQRIGKGSFGEVYK
Kinase IRAKf_g.AA LRRK 522-537 37 0.037369 3.4 In-house 336-351 (351) Show / Hide 
Range on Protein: 522-537
Range on HMM: 336-351/351
Sequence Identity: 37% (6 aa)

PDDRPTMDNVVKMLES
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PKKRPHFSQIVKRLSQ
Kinase IRAKf_g.AA Pkinase_Tyr 516-535 35 0.040501 7.8 Pfam 251-270 (270) Show / Hide 
Range on Protein: 516-535
Range on HMM: 251-270/270
Sequence Identity: 35% (7 aa)

MCIAPLPDDRPTMDNVVKML
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QCWHYDPEDRPTFSEIHEQL
Kinase IRAKf_g.AA Dicty4 522-537 27 0.063111 2.41 In-house 260-277 (277) Show / Hide 
Range on Protein: 522-537
Range on HMM: 260-277/277
Sequence Identity: 27% (5 aa)

PDDRPTMDNVVKM--LES
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PQHRPSFEEIIQRRILEH
Kinase IRAKf_g.AA Dicty4-Unclassified 517-535 36 0.100429 1.64 In-house 245-263 (263) Show / Hide 
Range on Protein: 517-535
Range on HMM: 245-263/263
Sequence Identity: 36% (7 aa)

CIAPLPDDRPTMDNVVKML
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CWHNDPNKRPTMNQIIQYL