IRAKf_a

Species: S.moellendorffii
Alias: IRAKf_a
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAKf

Sequence

Name Sequence Type Origin Length Description Download
IRAKf_a.AA Protein None 869 None Fasta, JSON
IRAKf_a.NA RNA None 2610 None Fasta, JSON
IRAKf_a.kin_dom Protein Kinase Domain None 201 None Fasta, JSON

Protein domain

Protein domains of IRAKf_a.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LRRNT_2 IRAKf_a.AA LRRNT_2 1-30 31 8.3e-09 31.52 Pfam 12-46 (46) Show / Hide
Range on Protein: 1-30
Range on HMM: 12-46/46
Sequence Identity: 31% (11 aa)

RADLHD-PR--RALASWSEDS--ASPCNWTGIQCS
.. |.| ..   .|.||. .|  ...|.|||. |.
KSSLNDSDPHHGVLSSWNPSSSDSDCCSWTGVTCD

LRR_1 IRAKf_a.AA LRR_1 39-62 37 0.005565 14.74 Pfam 1-26 (26) Show / Hide
Range on Protein: 39-62
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

LLSLLDVSH-N--SFSGSVPPELFANC
 |  ||.|. |  ...|..||. | |.
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_TYP IRAKf_a.AA LRR_TYP 36-61 30 0.414182 2.99 SMART 1-24 (24) Show / Hide
Range on Protein: 36-61
Range on HMM: 1-24/24
Sequence Identity: 30% (8 aa)

VTQLLSLLDVSHNSFSGSVPPELFAN
 ..|   || |.| .  ..||..|..
LPNL-RELDLSNNQL-THLPPGAFQG

LRR_1 IRAKf_a.AA LRR_1 65-87 33 0.000193 19.92 Pfam 1-26 (26) Show / Hide
Range on Protein: 65-87
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

SLRYVFLSG-N--QLEGDLPDS-IASC
.|..  ||| |  .|.|..|.| . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_1 IRAKf_a.AA LRR_1 113-135 40 0.000239 19.59 Pfam 1-26 (26) Show / Hide
Range on Protein: 113-135
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

RLGSLDLSH-N--SLSGEIPPE-LGQC
.| .||||. |  .|.|.|||. . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_TYP IRAKf_a.AA LRR_TYP 111-135 44 0.008549 16.53 SMART 1-24 (24) Show / Hide
Range on Protein: 111-135
Range on HMM: 1-24/24
Sequence Identity: 44% (11 aa)

LSRLGSLDLSHNSLSGEIPPELGQC
|. | .||||.| |  ..||.. |.
LPNLRELDLSNNQL-THLPPGAFQG

LRR_1 IRAKf_a.AA LRR_1 89-111 33 0.131504 9.87 Pfam 1-26 (26) Show / Hide
Range on Protein: 89-111
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

SLEALGASE-N--RLSGSIPAG-VGSL
.|. |  |  |  .|.|.|| .   .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_1 IRAKf_a.AA LRR_1 137-159 40 0.004022 15.24 Pfam 1-26 (26) Show / Hide
Range on Protein: 137-159
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

MLVSLDLSY-N--LLSGEIPSF-LESL
 | .||||. |   |.|.||.  . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_1 IRAKf_a.AA LRR_1 210-232 33 0.000434 18.67 Pfam 1-26 (26) Show / Hide
Range on Protein: 210-232
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

ALRRLYLHN-N--NLQGALPPA-LAGC
 |..|.| . |  ||.| .||  . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_TYP IRAKf_a.AA LRR_TYP 208-232 40 0.032019 12.1 SMART 1-24 (24) Show / Hide
Range on Protein: 208-232
Range on HMM: 1-24/24
Sequence Identity: 40% (10 aa)

MKALRRLYLHNNNLQGALPPALAGC
. .||.|.|.||.|  .||| . ..
LPNLRELDLSNNQL-THLPPGAFQG

LRR_1 IRAKf_a.AA LRR_1 186-208 33 0.041935 11.63 Pfam 1-26 (26) Show / Hide
Range on Protein: 186-208
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

ELQELNLAE-N--DLGGTLPSS-IGSM
 ||.|.|   |   | |..|.| . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_1 IRAKf_a.AA LRR_1 161-184 25 0.494614 7.83 Pfam 1-26 (26) Show / Hide
Range on Protein: 161-184
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

RLEVLRLPG-N--SFSGGVPEWIVTGF
.|..| | | |  ...| .|...  ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_TYP IRAKf_a.AA LRR_TYP 184-207 36 0.751364 0.87 SMART 1-24 (24) Show / Hide
Range on Protein: 184-207
Range on HMM: 1-24/24
Sequence Identity: 36% (9 aa)

FPELQELNLAENDLGGTLPSSI-GS
 |.|.||.|  | |  .||. . ..
LPNLRELDLSNNQL-THLPPGAFQG

LRR_1 IRAKf_a.AA LRR_1 234-256 40 0.000748 17.83 Pfam 1-26 (26) Show / Hide
Range on Protein: 234-256
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

NLSTIDLSS-N--NFSGAIPDE-IFEL
|| ..|||. |  |..| ||.. .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_TYP IRAKf_a.AA LRR_TYP 234-256 34 0.732606 0.96 SMART 3-24 (24) Show / Hide
Range on Protein: 234-256
Range on HMM: 3-24/24
Sequence Identity: 34% (8 aa)

NLSTIDLSSNNFSGAIPDEIFEL
|| . |||.|..  ..|...|. 
NLRELDLSNNQL-THLPPGAFQG

LRR_1 IRAKf_a.AA LRR_1 257-279 22 20.413357 2.1 Pfam 1-26 (26) Show / Hide
Range on Protein: 257-279
Range on HMM: 1-26/26
Sequence Identity: 22% (6 aa)

ELERLALAM-N--SFSGGLPVA-LSSS
 |..| |   |  ...| .|   . . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_1 IRAKf_a.AA LRR_1 311-334 33 0.000743 17.84 Pfam 1-26 (26) Show / Hide
Range on Protein: 311-334
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

HLRSLNLGQ-N--GLSGSIPEELVAGL
.|..|.|.  |   |.|.||..   .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_1 IRAKf_a.AA LRR_1 336-358 48 0.002271 16.12 Pfam 1-26 (26) Show / Hide
Range on Protein: 336-358
Range on HMM: 1-26/26
Sequence Identity: 48% (13 aa)

ELSSLDLSS-N--FLTGYIPRS-FGGS
 | .||||. |   |||.|| | | . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_1 IRAKf_a.AA LRR_1 287-309 40 0.003945 15.27 Pfam 1-26 (26) Show / Hide
Range on Protein: 287-309
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

VIQSLDLSR-N--SLEGEIPPQ-VSGC
 .|.||||. |  .|.|.|||    ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_1 IRAKf_a.AA LRR_1 360-382 33 0.006174 14.58 Pfam 1-26 (26) Show / Hide
Range on Protein: 360-382
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

SLETLKLDD-N--ALVGIIPEG-LGNC
.|..| |.. |   |.| ||.. . |.
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_TYP IRAKf_a.AA LRR_TYP 334-357 50 0.026899 12.72 SMART 1-24 (24) Show / Hide
Range on Protein: 334-357
Range on HMM: 1-24/24
Sequence Identity: 50% (12 aa)

LSELSSLDLSSNFLTGYIPRSFGG
|..| .||||.| ||   |. |.|
LPNLRELDLSNNQLTHLPPGAFQG

LRR_TYP IRAKf_a.AA LRR_TYP 359-382 33 0.545465 2.01 SMART 2-24 (24) Show / Hide
Range on Protein: 359-382
Range on HMM: 2-24/24
Sequence Identity: 33% (8 aa)

PSLETLKLDDNALVGIIPEGLGNC
|.|..| |..|.|   .|.|. ..
PNLRELDLSNNQL-THLPPGAFQG

LRR_TYP IRAKf_a.AA LRR_TYP 309-333 32 0.679096 1.23 SMART 1-24 (24) Show / Hide
Range on Protein: 309-333
Range on HMM: 1-24/24
Sequence Identity: 32% (8 aa)

CQHLRSLNLGQNGLSGSIPEELVAG
  .||.|.|. | |  ..|... .|
LPNLRELDLSNNQL-THLPPGAFQG

LRR_1 IRAKf_a.AA LRR_1 408-430 55 9e-06 24.56 Pfam 1-26 (26) Show / Hide
Range on Protein: 408-430
Range on HMM: 1-26/26
Sequence Identity: 55% (15 aa)

SLQSLDLSS-N--HLTGQIPTS-FAQL
.||.||||. |  .|||.|| | | .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_1 IRAKf_a.AA LRR_1 384-406 48 6.2e-05 21.67 Pfam 1-26 (26) Show / Hide
Range on Protein: 384-406
Range on HMM: 1-26/26
Sequence Identity: 48% (13 aa)

SLRYLDLSQ-N--NLTGGIPVE-LADL
.|..||||  |  |||| || . .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_TYP IRAKf_a.AA LRR_TYP 406-429 45 0.021665 13.49 SMART 1-24 (24) Show / Hide
Range on Protein: 406-429
Range on HMM: 1-24/24
Sequence Identity: 45% (11 aa)

LSSLQSLDLSSNHLTGQIPTSFAQ
|..|..||||.|.||   |  |. 
LPNLRELDLSNNQLTHLPPGAFQG

LRR_1 IRAKf_a.AA LRR_1 432-456 35 0.138516 9.79 Pfam 1-26 (26) Show / Hide
Range on Protein: 432-456
Range on HMM: 1-26/26
Sequence Identity: 35% (10 aa)

NLSLFNVSH-N--SLAGPIPSDGAFPLL
||   ..|. |  .| | ||.. .|  |
NLQHLDLSGCNCCNLTGHIPPS-CF-NL

Kinase IRAKf_a.AA TKL 596-858 21 2e-61 210.39 In-house 1-364 (364) Show / Hide
Range on Protein: 596-858
Range on HMM: 1-364/364
Sequence Identity: 21% (81 aa)

IGRGGFGTVYKATLAA---------GRTVAVKKLSVPG-----------------------MVETQDEFEKRVQFL---GKIQHENLVNFQGYYFTPKL-
||.||||.|||...           |..|||||...                         . |.. ....... .    ...|.|.| | || . |.  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------QLLIYDFVPNGNLHSKLHEQSVLPWELRFKVALGAAQGLCYLHHKCR-----PRVIHYNFKSSNVLLDDGFN--------------AR
              ......|.|.|.. ||      |..|.. ||..|.|..||| .       | .|| . ||.|.|.|. ..              . 
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCK

VSDYGLAKLLHSRDRFVVM----------------NKLQS-SLGYLAPEC---------------GCESFKVTEKCDVYGFGVVLLELITGKPPVE-YLE
..|.||.. .. .     .                .  |  .....|||.                |..|. .|||||| ||.|| |..|...| . | .
ICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPY

NDVVIL---CDFVRSLADDGKPLLC------VDPKMVVYPEEEVMT-LIKLGLVCTSPVPANRPSMTEVVQIL
.....     ..    .|.|.....      .  | . .|.. ... ..||   | .. | .|||..|....|
MPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHH-K-M-CPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL

Kinase IRAKf_a.AA IRAK 591-858 24 6.3e-42 145.61 In-house 2-317 (317) Show / Hide
Range on Protein: 591-858
Range on HMM: 2-317/317
Sequence Identity: 24% (79 aa)

NKNSEIGRGGFGTVYKATLAAGR-TVAVKKLSVPGMVETQD---EFEK---RVQFLGKIQHENLVNFQGYYFTPKLQLLIYDFVPNGNLHSKLHEQSV--
.|.  || ||||.||.. .     ..|||||    ....     .|      .. . ...|.|.| . || . .    |.|.. ||| |.  |. |    
HKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQC

----LPWELRFKVALGAAQGLCYLHHKCRPR--VIHYNFKSSNVLLDDGFNARVSDYGLAKLL----HSRDRFV---VMNKLQSSLGYLAPECGC-ESFK
    |.|  |.....|.| |. .|| . .|   .|| . ||.|.|||. |..  .| ||.       |. .  .     .... .. |..||     . .
PPKPLSWHQRCSICWGTACGIQFLHQN-HPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQ

VTEKCDVYGFGVVLLELITGKPPVEYLENDVVILCDFVRSLADDGK--------------------PLLC------VDPKMVVYPEEEVMTLIKLGLVCT
 | | ||| ||.||||..|| ..|      .  | | .. ...  .                    |         .|..|   |....  .  . . |.
LTKKTDVYSFGIVLLEVLTGCRAVYDDRPEHYYLKDLCEEIMEEWGHLDSCQSTLWVGVATDAWAAPRRMQIYEKFIDHRMPPCPPNMEKEMCQCACCCG

SPVPANRPSMTEVVQIL
    ..|..|..|.| |
HHRANRRCDMAWVMQQL

Kinase IRAKf_a.AA TKL-Unique 594-788 31 1.4e-41 144.45 In-house 3-225 (290) Show / Hide
Range on Protein: 594-788
Range on HMM: 3-225/290
Sequence Identity: 31% (70 aa)

SEIGRGGFGTVYKATLAAGRTVAVKKLSV-PGMV-ETQDEFEKRVQFLGKIQ-HENLVNFQGYYF----TPKLQLLIYDFVPNGNLHSKLH---------
. ||.||.|.|||..  .|  ||.|....  .   |  .|||. |  . |.. |.|.| . || .    .|.   .. ...| |.|.. ||         
NKIGEGGYGQVYKGKW-RGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNN

-EQSVLPWELRFKVALGAAQGLCYLHHKCRPRVIHYNFKSSNVLLDDG-----FNARVSDYGLAKLLHSR-DRFVVMN------KLQSSLGYLAPECGCE
 . . |....| | |. .|||..||||.  | .|| . ||||.|.| .     .|....| ||.|.. .. . .. ..        ..|. ..|||  . 
NNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRM

S-FKVTEKCDVYGFGVVLLELITGK
. .. .||.||| ||.|| |..|.|
NFCQYSEKSDVYSFGIVLWEIATRK

Pkinase IRAKf_a.AA Pkinase 590-790 22 5.1e-33 117.82 Pfam 1-211 (293) Show / Hide
Range on Protein: 590-790
Range on HMM: 1-211/293
Sequence Identity: 22% (48 aa)

LNKNSEIGRGGFGTVYKATLAAGRT-VAVKKLSVPGMVETQDEFEKR---VQFLGKIQHENLVNFQGYYFTPKLQLLIYDFVPNG----NLHSKLH--EQ
. . . ||.|.||.|||..    .  ||||......  . .|.   |   .| . ...|.| | . ... ...   .. .....|     |.. ..  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

SVL--PWELRFKVALGAAQGLCYLHHKCRPRVIHYNFKSSNVLLDDGFNA----RVSDYGLAKLLHSRDRFVVMNKLQSSLGYLAPECGCE-SFKVTEKC
 ..  ...   ....  ..|| |.| .   ..||   |..|.|.|.  .     ...| ||||..    . . |. .  ...|.|||  .  . . . |.
GCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEV-IRGGQYYGPKV

DVYGFGVVLLELITGKPP
|....|..| |...|.||
DMWSCGCILYEMLCGRPP

Kinase IRAKf_a.AA TK 590-858 13 7.8e-33 106.82 In-house 1-486 (486) Show / Hide
Range on Protein: 590-858
Range on HMM: 1-486/486
Sequence Identity: 13% (68 aa)

LNKNSEIGRGGFG---TVYKATLAAGR--------------------------TVAVKKLSVPGMVETQDEFE-----------------KRVQFLG-KI
.    ..|.| ||   .|||...  ..                          .|||| |      . ...|.                  . ...  . 
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

QHENLVNFQGYYFTP------------KLQLLIYDFVPNGN----LHSKLHEQSV---------------------------------------------
.|.|.|.. |. . .            .  ...  ..|.|.    |.. |.. .                                              
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LPWELRFKVALGAAQGLCYLHHK----CRPRVIHYNFKSSNVLLDDGFN-----------ARVSDYG--
                               |. . .   .. .|.|. ||| |      ....| .    |.|.... .           ....|.|  
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

------LAKLLHSRDRFVVMN-------------------KLQSSLG-----YLAPECGCESF--------KVTEKCDVYGFGVVLLELIT-G-KPPVEY
      ||. ..|.|  ....                   ..|.| |     ..||||  .          | |.| ||. |||.. |. | | .|. ..
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGG

LENDVVIL----CDFVRSLADD-----------GKPLLCVDP---------KMVVYPEEEVMTLIKL-GLVCTSPVPANRPSMTEVVQIL
. |. |.      .... | .            |  . .  |         .|   |...  ... .  . | .. |. ||....... |
MSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRM-H-PPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL

Kinase IRAKf_a.AA LRRK 590-792 22 1.5e-29 101.75 In-house 1-284 (351) Show / Hide
Range on Protein: 590-792
Range on HMM: 1-284/351
Sequence Identity: 22% (67 aa)

LNKNSEIGRGGFG-TVYKATLAA---------------------------GRTVAVKKLSVP---------------------------------GMVET
| ....||||||| .||.|..                             . .||.||. ..                                 .. . 
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

QDEFEKRVQFLGKIQHENLVNFQGYYFTPKLQLLIYDFVPNGNLHSKLH---EQS------VLPWELRFKVALGAAQGLCYLHHKCRPRVIHYNFKSSNV
  || . |  . . .| |.|.  |. . |    .. ...|.|.|.. ||   . .      ...| |. |.||  | |. || |...| .|| . || |.
FREFRHEVWIMSHLNHPNIVSLKGFCIHP--LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYL-HSHNPPIIHRDLKSPNI

LL---D---------DGFNARVSDYGLAK----LLHSRDRFVVMNKLQSSLGYLAPECGCES--FKVTEKCDVYGFGVVLLELITGK-PPVE
||   .         .  .| ..|.|.      ....  ...| |.     |..|||.  .      ||| |.| ||..| ||.|.. .| .
LLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNP-----GWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFD

Kinase IRAKf_a.AA MLK 590-790 25 3.2e-29 98.57 In-house 1-235 (291) Show / Hide
Range on Protein: 590-790
Range on HMM: 1-235/291
Sequence Identity: 25% (60 aa)

LNKNSEIGRGGFGTVYKATLAAGR----TVAVKKLS---VPGMVET---QDEFEKRVQFLGKIQHEN----LVNFQGY-YFTPKLQLLIYDFVPNGNLHS
..    || |.|| |.|..  . .    .||||.        ...|   |..||. .  | ...|.|     . | |    .|.  ...  ....| |..
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

KLHEQS--------------VLPWELRFKVALGAAQGLCYLHHKCRPRVIHYNFKSSNVLLDD------GFNARVSDYGLAKLLHSRDRFVVMNKLQSSL
 ||...              | . .. .. ||  |.|. ||| . .. .||.  ||.|.|.|.      . .....| |... .|...    | . . ..
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC--TNMMSNAGTY

GYLAPECG--CESFKVTEKCDVYGFGVVLLELITGKPP
 . |||     .. |..|||||. .|||| |..|.. |
AWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVP

Kinase IRAKf_a.AA S_TKc 590-861 20 3.4e-29 104.24 SMART 1-231 (231) Show / Hide
Range on Protein: 590-861
Range on HMM: 1-231/231
Sequence Identity: 20% (58 aa)

LNKNSEIGRGGFGTVYKATLAA-GRTVAVKKLSVPGMVETQDEFEKRVQFLGKIQHENLVNFQGYYFTPKLQLLIYDFVPN--GNLHSKLHEQSV-----
  .  .||.|.||.|||..    || ||.|...        . ... .| | | .|.|.|.. ... . .   .. .....  |.|.. ....       
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LPWELRFKVALGAAQGLCYLHHKCRPRVIHYNFKSSNVLLDDGFNARVSDYGLAKLLHSRDRFVVMNKLQSSLGYLAPECGCESFKVTE-KCDVYGFGV
 .|     ...   ...| |.| .    .||   | .|.|||.  .  ..| |||..|         . .  .. |.|||      . .  |||.. .|.
PFPE-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGC

VLLELITGKPPVEYLENDVVILCDFVRSLADDGKPLLCVDPKMVVYPEEEVMTLIKLGLVCTSPVPANRPSMTEVVQ------ILELI
.| |...|.|| .    ..  . . ..                     .|.  .|.  |.     |..||.  |. |      . . .
ILYEMLCGYPPFP----QMQMMFKKIG--------------------SPEAKDFIRKCLQ---KDPEKRPTA-EALQDEWDIKCHPWF

Kinase IRAKf_a.AA RIPK 596-858 25 3.9e-28 92.95 In-house 1-290 (290) Show / Hide
Range on Protein: 596-858
Range on HMM: 1-290/290
Sequence Identity: 25% (75 aa)

IGRGGFGTVYKATLAAGRTVAVKKLSV-PGMVET-----QDEFEKRVQFLGKIQHENLVNFQGYYFTP------KLQLLIYDFVPNGNLHSKLHEQSV--
.|.||||.|.||. .  .....|| .  . . ..     . .    .. . |...|. |   |    .      ||. .   . .||.|   || ..   
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ

---LPWELRFKVALGAAQGLCYLHHKCRPRVIHYNFKSSNVLLDDGFNARVSDYGLAKLLHSR----DRF-----VVMNKLQS--SLGYLAPECGC--ES
   .|| ||.      . | |||| .  | .||   | .|.|.|  |.. ..| |||. .       ||        | ....   | |..||     ..
HHPDPWPLRCRMIHEISCGMCYLHSM-NPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDNK

FK---VTEKCDVYGFGVVLLELITGKPPVEYLENDVVILCDFVRSLADDGKPLLCVDPKMVVYPEE-EVMTLIKLGLVCTSPVPANRPSMTEVVQIL
     ||.| ||| |..|. |. |.| | |  ... .|.     ... .  |  |..|  . .||  ..  .|.|   | .  | .||.  |.    
KPIKVVTPKYDVYSFAIVMWEVLTQKHPYEDRKCMMMIMM----CCKQGHRP--CLQPVPEYWPEPPHCEQMIELMQRCWQQDPNDRPCFQECEEWT

Kinase IRAKf_a.AA Pkinase_Tyr 590-790 25 6.8e-26 88.32 Pfam 1-214 (270) Show / Hide
Range on Protein: 590-790
Range on HMM: 1-214/270
Sequence Identity: 25% (55 aa)

LNKNSEIGRGGFGTVYKATLA-----AGRTVAVKKLSVPGMVET--QDEFEKRVQFLGKI-QHENLVNFQGYYF-TPKL--QLLIYDFVPNGNLHSKLHE
. .. ..|.| ||.|||.|.       . .||||.|    | |   ...| . .. . .. .|.|.|.. |      .    ...  ..|.|.|.. |..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

----QSVLPWELRFKVALGAAQGLCYLHHKCRPRVIHYNFKSSNVLLDDGFNARVSDYGLAKLLHSRDRF-VVMNKLQSSLGYLAPECGCESFKVTEKCD
    .  |. .   . ..  |.|. ||. |     ||      |.|..... ....| |||..... |   ..  .       .||||     | |.| |
HREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPEC-INYGKFTTKSD

VYGFGVVLLELIT-GKPP
|. |||.. |..| |. |
VWSFGVLMWEIFTYGEQP

Kinase IRAKf_a.AA Dicty4-Unclassified 590-790 32 1.1e-24 81.39 In-house 1-207 (263) Show / Hide
Range on Protein: 590-790
Range on HMM: 1-207/263
Sequence Identity: 32% (70 aa)

LNKNSEIGRGGFGTVYKATLAAGRTVAVKKLSVPGMVETQ----DEFEKRVQFLGKIQHENLVNFQGYYFTP---KLQLLI-YDFVPNGNLHSKLH----
.    .||.| |  |.|     |. |||||.   .         ..| | |  || ||| |||   ||   |   |  . |   | . |||    |    
IQIDQFIGKGHFSKVHKGNW-KGKDVAVKKFNE-NKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPS

-EQSVLPWEL--RFKVALGAAQGLCYLHHKCRPRVIHYNFKSSNVLLDDGFNARVSDYGLAKLLHSRDRFVVMNKLQSSLGYLAPEC-GCESFKVTEKCD
  |  .  .     |.|.  |||. .|| .    .||   ||||.|.|  ||... | |..      |    |          .|||   ||.  . | |
EQQQPIKLDDTLIIKYAFDIAQGMQHLHTR---NFIHRDIKSSNILMDKHFNIKIADFGISRVI---DFNFNMTTIAGTPKWESPECLMHESY--NQKSD

VYGFGVVLLELITGKPP
|| ....| ||.||  |
VYSYAMMLYELATGDEP

Kinase IRAKf_a.AA Dicty4 590-736 35 6.1e-24 76.87 In-house 1-162 (277) Show / Hide
Range on Protein: 590-736
Range on HMM: 1-162/277
Sequence Identity: 35% (59 aa)

LNKNSEIGRGGFGTVYKATLAAGRTVAVKKL--SVPGM-VETQDEFEKRVQFLGKIQHENLVNFQGYYF----TPKLQLLIYDFVPNGNLHSKLHE----
.|. ..||.|.||.|||.|   |  ||||||     .   ..  || | |  ..||.| |.. | |.      .|   .    ..| |||.| ||     
INIEQRIGKGSFGEVYKGTW-RGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSE

--QSV-LPWELRFK---VALGAAQGLCYLHHKCRPRVIHYNFKSSNVLLDDGFNARVSDYGLAK
  ||. |.|.|. .    |. ||.|. .||  | |..||   ||.| | |. ... |.| ||..
QQQSIKLDWPLIKRAMRMAFDAARGMNWLHC-CNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQ

Kinase IRAKf_a.AA LISK 595-738 31 2.6e-22 69.13 In-house 1-155 (296) Show / Hide
Range on Protein: 595-738
Range on HMM: 1-155/296
Sequence Identity: 31% (49 aa)

EIGRGGFGTVYKATLA-AGRTVAVKKLSV----PGMVETQDEFEKRVQFLGKIQHENLVNFQGYYFT-PKLQLLIYDFVPNGNLHSKLH-EQS---VLPW
|||.|.|| ||| |.   |. .|.|...     |   |.|  ... || . ...| | |.| | .    .   ..  ..  |.||  |. . .   .|||
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW

ELRFKVALGAAQGLCYLHHKCRPRVIHYNFKSSNVLLD----DGFNARVSDYGLAKLL
..| | ||. |.|. ||| ..   .||   || |.|..    ......| | |.|...
PQRVKIALDIACGMSYLHSMN---IIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMM

Kinase IRAKf_a.AA TyrKc 590-858 22 4.9e-22 80.46 SMART 1-280 (280) Show / Hide
Range on Protein: 590-858
Range on HMM: 1-280/280
Sequence Identity: 22% (65 aa)

LNKNSEIGRGGFGTVYKATLAAGRTVAVKKLSVPGMVETQDEFEKRVQFLGKI--QHENLVNFQGYYFTP-------KLQLLIYDFVPNGNLHSKLHEQS
. .. ..|.| ||.|||.|.   ..||||.|        . .| .  . . |.  .|.|.|.. |.  ..       .  ...  ..|.|.|.. |..  
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

V-LPWELRFKVALGAAQGLCYLHHKCRPRVIHYNFKSSNVLLDDGFNARVSDYGLAKLLHSR-------DRFVVMN--KLQ--SSLGYLAPECGCESFKV
  |...   . .. .|.|  |||.|   ..||      |.|..... ...|| ||.. ...        |  ...          .  .||||     | 
PKLCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKF

TEKCDVYGFGVVLLELIT-GKPPVEYLENDVVILCDFVRSLADDGKPLLCVDP----KMVVYPEEEVMTLIKLGLVCTSPVPANRPSMTEVVQIL
|.| ||. |||.. |. | |..| .  .   ..  . |. . ..|. . . .        |   .|. ...|    |    |..||...|.....
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSF-VCCPDEMYQIMKQ---CWHEDPEDRPTFSEIHECF

Kinase IRAKf_a.AA LISK 769-794 44 1.2e-08 23.95 In-house 217-243 (296) Show / Hide
Range on Protein: 769-794
Range on HMM: 217-243/296
Sequence Identity: 44% (12 aa)

TEKCDVYGFGVVLLELITGKPPVE-YL
.|.|||. ||.||.|.||.. . . |.
DESCDVFSFGIVLCEIITRVKADPDYW

Kinase IRAKf_a.AA MLK 840-858 42 0.000108 12.36 In-house 273-291 (291) Show / Hide
Range on Protein: 840-858
Range on HMM: 273-291/291
Sequence Identity: 42% (8 aa)

CTSPVPANRPSMTEVVQIL
| .. |..|||. ..||.|
CWNQDPHKRPSFRQIVQHL

Kinase IRAKf_a.AA Dicty4 845-860 44 0.000218 10.74 In-house 260-277 (277) Show / Hide
Range on Protein: 845-860
Range on HMM: 260-277/277
Sequence Identity: 44% (8 aa)

PANRPSMTEVVQI--LEL
| .|||. |..|.  || 
PQHRPSFEEIIQRRILEH

Kinase IRAKf_a.AA Dicty4 769-790 54 0.000584 9.29 In-house 195-216 (277) Show / Hide
Range on Protein: 769-790
Range on HMM: 195-216/277
Sequence Identity: 54% (12 aa)

TEKCDVYGFGVVLLELITGKPP
.|| ||| || || |. |.. |
NEKADVYSFGIVLWEILTRQEP

Kinase IRAKf_a.AA LRRK 840-860 28 0.000933 9.15 In-house 331-351 (351) Show / Hide
Range on Protein: 840-860
Range on HMM: 331-351/351
Sequence Identity: 28% (6 aa)

CTSPVPANRPSMTEVVQILEL
| .  | .||.....|..|. 
CWQHDPKKRPHFSQIVKRLSQ

Kinase IRAKf_a.AA LISK 833-858 42 0.00507 5.43 In-house 271-296 (296) Show / Hide
Range on Protein: 833-858
Range on HMM: 271-296/296
Sequence Identity: 42% (11 aa)

LIKLGLVCTSPVPANRPSMTEVVQIL
...| . |..  | |||| .|.||.|
FLDLCFDCCKYDPKNRPSFKEIVQWL

Kinase IRAKf_a.AA Dicty4-Unclassified 840-858 36 0.009752 5.16 In-house 245-263 (263) Show / Hide
Range on Protein: 840-858
Range on HMM: 245-263/263
Sequence Identity: 36% (7 aa)

CTSPVPANRPSMTEVVQIL
| .  |  ||.| ...| |
CWHNDPNKRPTMNQIIQYL

Kinase IRAKf_a.AA Pkinase_Tyr 845-858 35 0.17234 5.67 Pfam 257-270 (270) Show / Hide
Range on Protein: 845-858
Range on HMM: 257-270/270
Sequence Identity: 35% (5 aa)

PANRPSMTEVVQIL
|..||...|....|
PEDRPTFSEIHEQL