Gene IRAKf_k-1 (S.moellendorffii)

IRAKf_k-1

Species: S.moellendorffii
Alias: IRAKf_k-1
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAKf

Sequence

Name Sequence Type Origin Length Description Download
IRAKf_k-1.AA Protein None 976 None Fasta, JSON
IRAKf_k-1.NA RNA None 2931 None Fasta, JSON
IRAKf_k-1.kin_dom Protein Kinase Domain None 267 None Fasta, JSON

Protein domain

Protein domains of IRAKf_k-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LRRNT_2 IRAKf_k-1.AA LRRNT_2 17-51 43 9.3e-09 31.36 Pfam 8-46 (46) Show / Hide 
Range on Protein: 17-51
Range on HMM: 8-46/46
Sequence Identity: 43% (17 aa)

LLEIKKSLNN--A-DNVLYDWEGAI-DRDPCFWRGVSCD
||..|.|||.    ..|| .|     | |.| |.||.||
LLAFKSSLNDSDPHHGVLSSWNPSSSDSDCCSWTGVTCD
LRR_1 IRAKf_k-1.AA LRR_1 56-78 29 49.63143 0.73 Pfam 1-26 (26) Show / Hide 
Range on Protein: 56-78
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

AVIGLNLTQ-L--GLSGEISPA-FGRL
    |.|       |.|.|.|  |  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKf_k-1.AA LRR_1 80-102 37 4.6e-05 22.14 Pfam 1-26 (26) Show / Hide 
Range on Protein: 80-102
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

SLQYLDLRE-N--SLSGQIPDE-IGQC
.||.|||.  |  .|.|.||.. . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKf_k-1.AA LRR_1 104-126 40 0.001499 16.76 Pfam 1-26 (26) Show / Hide 
Range on Protein: 104-126
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

NLKTIDLSF-N--AFHGDIPFS-ISQL
||...|||  |   . |.|| | . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKf_k-1.AA LRR_1 128-150 37 0.003003 15.69 Pfam 1-26 (26) Show / Hide 
Range on Protein: 128-150
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

QLENLILKN-N--QLTGPIPST-LSQL
.|. | | . |  .||| ||.  . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKf_k-1.AA LRR_1 152-173 40 0.006806 14.43 Pfam 1-26 (26) Show / Hide 
Range on Protein: 152-173
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

NLKTLDLAQ-N--KLTGEIPT--LLYW
||..|||   |  .|||.||   .   
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKf_k-1.AA LRR_1 176-198 37 0.268637 8.77 Pfam 1-26 (26) Show / Hide 
Range on Protein: 176-198
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

VLQYLGLRD-N--LLTGNLSPD-MCRL
 ||.| |.. |   |||...|.    |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKf_k-1.AA LRR_1 200-222 33 0.005938 14.64 Pfam 1-26 (26) Show / Hide 
Range on Protein: 200-222
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

GLWYFDIRS-N--NITGPIPEN-IGNC
 | . |... |  |.|| ||.. . |.
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKf_k-1.AA LRR_1 226-246 44 0.006546 14.49 Pfam 3-26 (26) Show / Hide 
Range on Protein: 226-246
Range on HMM: 3-26/26
Sequence Identity: 44% (11 aa)

EILDLSY-N--QLTGEIPFN-IGFL
..||||. |  .|||.|| . .  |
QHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKf_k-1.AA LRR_1 247-268 33 0.187954 9.32 Pfam 1-26 (26) Show / Hide 
Range on Protein: 247-268
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

QVATLSLQG-N--KLVGKIPD--VIGL
.  .|.|.| |  .|.|.||.    .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKf_k-1.AA LRR_1 271-293 44 0.000339 19.05 Pfam 1-26 (26) Show / Hide 
Range on Protein: 271-293
Range on HMM: 1-26/26
Sequence Identity: 44% (12 aa)

ALAVLDLSN-N--FLEGSIPSI-LGNL
 | .||||. |   |.|.||.  . ||
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKf_k-1.AA LRR_1 298-317 45 0.077714 10.68 Pfam 4-26 (26) Show / Hide 
Range on Protein: 298-317
Range on HMM: 4-26/26
Sequence Identity: 45% (11 aa)

KLYLHG-N--MLTGVIPPE-LGNM
.|.| | |   ||| |||. . |.
HLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKf_k-1.AA LRR_1 319-341 44 0.000251 19.51 Pfam 1-26 (26) Show / Hide 
Range on Protein: 319-341
Range on HMM: 1-26/26
Sequence Identity: 44% (12 aa)

KLSYLQLND-N--NLTGQIPPE-LGSL
.| .| |.. |  ||||.|||. . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKf_k-1.AA LRR_1 343-365 29 0.024782 12.44 Pfam 1-26 (26) Show / Hide 
Range on Protein: 343-365
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

ELFELDLSN-N--KFSGPFPKN-VSYC
 | .||||. |  ...| .|..    .
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKf_k-1.AA LRR_1 367-389 29 0.038043 11.78 Pfam 1-26 (26) Show / Hide 
Range on Protein: 367-389
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

SLNYINVHG-N--MLNGTVPPE-LQDL
.| .... | |   | |..||. .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKf_k-1.AA LRR_1 391-413 29 0.000251 19.51 Pfam 1-26 (26) Show / Hide 
Range on Protein: 391-413
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

SLTYLNLSS-N--SFSGRIPEE-LGHI
.|..|.||. |  ...| ||.. . . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKf_k-1.AA LRR_1 415-437 55 0.001378 16.89 Pfam 1-26 (26) Show / Hide 
Range on Protein: 415-437
Range on HMM: 1-26/26
Sequence Identity: 55% (15 aa)

NLDTMDLSE-N--ILTGHIPRS-IGNL
|| . |||  |   |||||| | . ||
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKf_k-1.AA LRR_1 439-461 40 0.005938 14.64 Pfam 1-26 (26) Show / Hide 
Range on Protein: 439-461
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

HLLTLVLKH-N--KLTGGIPSE-FGSL
.| .| | . |  .||| ||.. | .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKf_k-1.AA LRR_1 463-485 40 0.009602 13.9 Pfam 1-26 (26) Show / Hide 
Range on Protein: 463-485
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

SIYAMDLSE-N--NLSGSIPPE-LGQL
..   |||  |  ||.|.|||. . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKf_k-1.AA LRR_1 487-509 37 0.109641 10.15 Pfam 1-26 (26) Show / Hide 
Range on Protein: 487-509
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

TLNALLLEK-N--SLSGSIPPQ-LGNC
.|  | |   |  .|.|.|||  . |.
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKf_k-1.AA LRR_1 511-534 44 0.000886 17.57 Pfam 1-26 (26) Show / Hide 
Range on Protein: 511-534
Range on HMM: 1-26/26
Sequence Identity: 44% (12 aa)

SLSTLNLSY-N--NLSGEIPASSIFNR
.| .|.||. |  ||.|.|| |.. | 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
Kinase IRAKf_k-1.AA TKL 643-903 20 4.8e-61 209.12 In-house 1-364 (364) Show / Hide 
Range on Protein: 643-903
Range on HMM: 1-364/364
Sequence Identity: 20% (75 aa)

VGRGASSSVYKCTLKN---------GKKVAIKRLYNHYPQNV---------------------------HEFETELATLGHIKHRNLVSLYGYSLSSAG-
.|.|... ||| ....         || ||.|..  |. ..                             ..| |.  .  ..| |.|...||.... . 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------NLLFYDFMDNGSLWDILHGPVRKVTLDWDARLIIALGAAQGLEYLHHNCS-----PRIIHRDVKSSNILLDERFE-------------
              . ......|||...||         |. |. .||..|.|..||| .       | ||||| ||.|||.|| ..             
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW

-VHLSDFGIAKSICSASTHTSTY------------------VMGTIGYIDPEYARTS----------------RLNEKSDVYSFGIVLLELITRQKAVDD
 . ..|||......  .  . |                   . ||...  ||  | .                  .||.||||||||| |..||.. . .
CCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR-PYY

EKNLHQWVLSHVNNKSVMEIVDQEVKDTCTD------------PNAIQKLIRLALLCAQKFPAQRPTMHDVVNVI
. .  .......  .  ...| .. .    .            |.. . ...|.  | .  | .||.. ...  .
DYPYMPMIFQDP-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAKf_k-1.AA IRAK 638-841 35 3.4e-51 176.38 In-house 2-227 (317) Show / Hide 
Range on Protein: 638-841
Range on HMM: 2-227/317
Sequence Identity: 35% (81 aa)

HERFLVGRGASSSVYKCTLKNGK-KVAIKRLYNHYPQNVHE----FET---ELATLGHIKHRNLVSLYGYSLSSAGNLLFYDFMDNGSLWDILHGPVRKV
|. .. | |.   ||.  .||    .|.|.| ..   .  |    | .   || ..  . | |.|.||||.. .    | |..| |||| | |..    .
HKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQC

T---LDWDARLIIALGAAQGLEYLHHNCSP-RIIHRDVKSSNILLDERFEVHLSDFGIAK------SICSAST---HTSTYVMGTIGYIDPEYAR--TSR
.   | |  |. |..|.| |...|| | .   |||.|.||.|||||..|.  ..||| .       .  ...    .||. | ||  |  ||. |  . .
PPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSH-VRGTTWYMPPEFIRDPQGQ

LNEKSDVYSFGIVLLELITRQKAVDDE
|  |.|||||||||||..| ..||.|.
LTKKTDVYSFGIVLLEVLTGCRAVYDD
Kinase IRAKf_k-1.AA TKL-Unique 642-835 31 2.2e-41 143.69 In-house 4-225 (290) Show / Hide 
Range on Protein: 642-835
Range on HMM: 4-225/290
Sequence Identity: 31% (71 aa)

LVGRGASSSVYKCTLKNGKKVAIKRLYN---HYPQNVHEFETELATLGHIK-HRNLVSLYGYSL----SSAGNLLFYDFMDNGSLWDILH-------GPV
..|.|....||| .  .|..||||.. .     .. . ||| |. ..  .. | |.| ..||.     . .   .. .... ||| | ||          
KIGEGGYGQVYKGKW-RGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNN

RKVTLDWDARLIIALGAAQGLEYLHHNCSPRIIHRDVKSSNILLDER-----FEVHLSDFGIAKSICSASTHTST--------YVMGTIGYIDPEYART-
.. .|..  |. .|. .|||..||||.  | ||||| ||||.|.|..     . . ..|||..|.  . .. |..         ..|.. .. ||  |  
NNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMN

-SRLNEKSDVYSFGIVLLELITRQ
 .  .|||||||||||| |..||.
FCQYSEKSDVYSFGIVLWEIATRK
Kinase IRAKf_k-1.AA Dicty4-Unclassified 637-833 33 4.1e-36 121.16 In-house 1-203 (263) Show / Hide 
Range on Protein: 637-833
Range on HMM: 1-203/263
Sequence Identity: 33% (69 aa)

LHERFLVGRGASSSVYKCTLKNGKKVAIKRL-YNHYPQN---VHEFETELATLGHIKHRNLVSLYGYSLSS----AGNLLFYDFMDNGSLWDILH--GPV
.     .|.|. | |.|   | || ||.| .  | .      . .|  | . || | | ||| .|||..      .       ||  | |  . |     
IQIDQFIGKGHFSKVHKGNWK-GKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSE

RKVTLDWDA--RLIIALGAAQGLEYLHHNCSPRIIHRDVKSSNILLDERFEVHLSDFGIAKSICSASTHTSTYVMGTIGYIDPEYARTSRLNEKSDVYSF
..  .  |    . .|.  |||. .||   .  .||||.||||||.|  | .   ||||.  |    . . | . ||     ||  .    | ||||||.
QQQPIKLDDTLIIKYAFDIAQGMQHLH---TRNFIHRDIKSSNILMDKHFNIKIADFGISRVI--DFNFNMTTIAGTPKWESPECLMHESYNQKSDVYSY

GIVLLELIT
...| ||.|
AMMLYELAT
Pkinase IRAKf_k-1.AA Pkinase 637-835 25 2.8e-35 125.81 Pfam 1-209 (293) Show / Hide 
Range on Protein: 637-835
Range on HMM: 1-209/293
Sequence Identity: 25% (56 aa)

LHERFLVGRGASSSVYKCTLKNGKK-VAIKRLYNHYPQNVHEFET-----ELATLGHIKHRNLVSLYGYSLSSAGNLLFYDFMDNG----SLWDILHGPV
.|    .|.|....||||. |.  | ||.|..  .  ..  . .|     |.. . ...| | | ||..  ..    .  .....|    .|.|....  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST-W

RKVTL--DWDARLIIALGAAQGLEYLHHNCSPRIIHRDVKSSNILLDERFEV----HLSDFGIAKSI-CSASTHTSTYVMGTIGYIDPEYAR-TSRLNEK
|. ..  ...    ...  ..||||.| .   .|||||.|..|||.|.. ..    ...|||.|| .    .. ..|.. ||..|. ||  |  .    |
RHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFC-GTPWYMAPEVIRGGQYYGPK

SDVYSFGIVLLELITRQ
.|..|.|..| |.....
VDMWSCGCILYEMLCGR
Kinase IRAKf_k-1.AA Dicty4 637-835 32 3.8e-35 114.79 In-house 1-214 (277) Show / Hide 
Range on Protein: 637-835
Range on HMM: 1-214/277
Sequence Identity: 32% (71 aa)

LHERFLVGRGASSSVYKCTLKNGKKVAIKRL--YNHY--PQNVHEFETELATLGHIKHRNLVSLYGYSL----SSAGNLLFYDFMDNGSLWDILHG----
.    . |.|. ..||| | . ||.||.| |   |         ||  | . .. | | |.. ..|...     .   .    .|  |.|  .||     
INIEQRIGKGSFGEVYKGTWR-GKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSE

PVRKVTLDWDARLI---IALGAAQGLEYLHHNCSPRIIHRDVKSSNILLDERFEVHLSDFGIAKSICSASTHTS--TYVMGTIGYIDPEYARTSRLNEKS
   ...|||  ..    .|. ||.|. .| |.| |.||||| ||.|.| |. . |  .|||... .   ..|.   . . || ..  ||  .  . |||.
QQQSIKLDWPLIKRAMRMAFDAARGMNWL-HCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKA

DVYSFGIVLLELITRQ
||||||||| |. |||
DVYSFGIVLWEILTRQ
Kinase IRAKf_k-1.AA MLK 637-835 27 4.2e-35 119.27 In-house 1-233 (291) Show / Hide 
Range on Protein: 637-835
Range on HMM: 1-233/291
Sequence Identity: 27% (66 aa)

LHERFLVGRGASSSVYKCTLKNGKK-----VAIKRLY-NHYPQNVHE------FETELATLGHIKHRN----LVSLYGYSLSSAGN-LLFYDFMDNGSLW
. .   .| |.. .|.| . .| |      ||.||   . .   . .      ||.|   | ...|.|     . .|| .|..  . ..   ....||| 
IQFHEWIGSGSFGKVWKGRWRN-KDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLY

DILHG-PV----------RKVTLDWDARLIIALGAAQGLEYLHHNCSPRIIHRDVKSSNILLDE------RFEVHLSDFGIAKSICSA-STHTSTYVMGT
..||| .           . .. | |  . .||  |.|..||| .  . ||||| ||.|||.||         .  .|||.......  ....|.  .||
NVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSN--AGT

IGYIDPEY---ARTSRLNEKSDVYSFGIVLLELITRQ
  .  ||    .| .. .||.||.|.|.|| |..||.
YAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTRE
Kinase IRAKf_k-1.AA STE 638-835 20 4.3e-35 121.4 In-house 1-265 (359) Show / Hide 
Range on Protein: 638-835
Range on HMM: 1-265/359
Sequence Identity: 20% (56 aa)

HER-FLVGRGASSSVYKCTLKN----------------GKKVAIKRLYNHYP-----------------QNVHEFETELATLGHIK--HRNLVSLYGYSL
 |.   .|.||. .|||.  ..                |. .|||..                      ... ... |. .. . .  | | |  ||. .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

-----SSAGN--LLFYDFMDNGSLWDILH---GPVRK--------VTLDWDARLIIALGAAQG-LEYLHHNCSPRIIHRDVKSSNILLDERFEVHLSDFG
     .....   ..  .||.||| ||..   |. .          ... .   .|.    .| |.||| .    |||||.|..||||     | |.|||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDFG

IAKSICS--------------ASTH-TSTYVMGTIGYIDPEYARTSR------LNEKSDVYSFGIVLLELITRQ
..... .              ...   .. . ||  .  ||  .  .       ..|.|..|.|....|..| .
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK
Kinase IRAKf_k-1.AA RIPK 643-903 24 2.4e-33 110.95 In-house 1-290 (290) Show / Hide 
Range on Protein: 643-903
Range on HMM: 1-290/290
Sequence Identity: 24% (73 aa)

VGRGASSSVYKCTLKNGKKVAIKRLYN----HYP---QNVHEFETELATLGHIKHRNLVSLYGYSLSS-----AG-NLLFYDFMDNGSLWDILHGPV--R
||.|... |.|.. .  . ...|  ..    | .   | . .   | . .  ..... |..||           .   .   .| |||||. ||      
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ

KVTLDWDARLIIALGAAQGLEYLHHNCSPRIIHRDVKSSNILLDERFEVHLSDFGIAKSICSASTHT------------STYVMGTIGYIDPEYAR---T
.  . |. |  .    . |  || |.  | ||||| | .|||.|  | | ..||| |.     . |.            |    ||. |..||  |    
HHPDPWPLRCRMIHEISCGMCYL-HSMNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDNK

SR---LNEKSDVYSFGIVLLELITRQKAVDDEKNLHQWVLSHVNNKSVMEIVDQEVKDTCTDPNAIQKLIRLALLCAQKFPAQRPTMHDVVNVI
..    ..|.|||||.||. |. |. ..  |.|.  . ... .. ..  ..  |.| . .  | .....|.|  .| |  | .||.  ..   .
KPIKVVTPKYDVYSFAIVMWEVLTQKHPYEDRKCMMMIMMC-CKQGHRPCL--QPVPEYWPEPPHCEQMIELMQRCWQQDPNDRPCFQECEEWT
Kinase IRAKf_k-1.AA DRK 643-835 36 1.8e-32 107.31 In-house 7-199 (258) Show / Hide 
Range on Protein: 643-835
Range on HMM: 7-199/258
Sequence Identity: 36% (72 aa)

VGRGASSSVYKCTLKNGKKVAIKRLYNHYPQNVH------EFETELATLGHIKHRNLVSLYGYSLSSAGNLLFYDFMDNGSLWDILHGPVRKVTLDWDAR
.|||    |.  |   | .||.|.| ||   |.       ||  |   .    | | .   |  . .   .    .|  |||  ||| .  .. .||  .
IGRGNYGEVFRGTWR-GTQVAVKMLFNH---NINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDE--SIEMDWPLM

LIIALGAAQGLEYLHHNCSPRIIHRDVKSSNILLDERFEVHLSDFGIAKSICSASTHTSTYVM-GTIGYIDPEYARTSRLNEKSDVYSFGIVLLELITRQ
. ... .| |. || |.| | ||||| || | | || . |  .||| .        |. .  | || . . ||  |  |  || |||||.||| |..|||
KQMMFDCAKGMIYL-HCCNPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQHKFAMTMCGTPCWTAPEVLRNQRYTEKADVYSFAIVLWECVTRQ
Kinase IRAKf_k-1.AA LRRK 637-840 24 3e-32 111.36 In-house 1-285 (351) Show / Hide 
Range on Protein: 637-840
Range on HMM: 1-285/351
Sequence Identity: 24% (70 aa)

LHERFLVGRGASS-SVYKCTLKN---------------------------GKKVAIKRLYNH----------------------------------YPQN
| .  ..|||..  .||. ....                           ...|||| .  .                                   . .
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

VHEFETELATLGHIKHRNLVSLYGYSLSSAGNLLFYDFMDNGSLWDILHGPVRKV------TLDWDARLIIALGAAQGLEYLHHNCSPRIIHRDVKSSNI
 .||  |.. . | .| |.|||.|....     .  .....|.| . || . .         ..|  .| |||  | |.||| |...| ||||| || ||
FREFRHEVWIMSHLNHPNIVSLKGFCIHPL--CMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYL-HSHNPPIIHRDLKSPNI

LL---D---------ERFEVHLSDFGIAKSICSASTHT-STYVMGTIGYIDPEYAR---TSRLNEKSDVYSFGIVLLELITRQ-KAVDD
||   .         .   ....||||   . .. ...    . |..|.  ||  |   ..  .||.|.||||..| ||.|||  . |.
LLWSSPQNHSPNYPNAHVCAKIADFGISR-MFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDE
Kinase IRAKf_k-1.AA Pkinase_Tyr 637-834 26 1.1e-29 101.11 Pfam 1-210 (270) Show / Hide 
Range on Protein: 637-834
Range on HMM: 1-210/270
Sequence Identity: 26% (58 aa)

LHERFLVGRGASSSVYKCTLK-----NGKKVAIKRLYNHYPQN---VHEFETELATLGHI-KHRNLVSLYGYSL-SSAG--NLLFYDFMDNGSLWDILHG
..     |.||  .|||.|.|     .. .||.| | ... .      .|  |.... .. .| |.|.|||  .  .     ..   .| .|.| | |. 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

P---VRKVTLDWDARLIIALGAAQGLEYLHHNCSPRIIHRDVKSSNILLDERFEVHLSDFGIAKSICSASTHTSTY-VMGT-----IGYIDPEYARTSRL
.    ...|. .   | ...  |.|.|||. .    .||||.   |.|..| . |  .||| |. |    .....| ....     |    ||  .... 
HREDKQPLTMKD--LLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDI----YNDDYYYRKRGGGKLPIKWMAPECINYGKF

NEKSDVYSFGIVLLELITR
..||||.|||... |..|.
TTKSDVWSFGVLMWEIFTY
Kinase IRAKf_k-1.AA S_TKc 637-904 24 2.3e-27 98.15 SMART 1-231 (231) Show / Hide 
Range on Protein: 637-904
Range on HMM: 1-231/231
Sequence Identity: 24% (68 aa)

LHERFLVGRGASSSVYKCTLKN-GKKVAIKRLYNHYPQNVHEFETELATLGHIKHRNLVSLYGYSLSSAGNLLFYDFMDN--GSLWDILHGPVRKVT---
 .   ..|.|| ..||||. |. |..||||..          .. |.. | . .| |.| ||..  .     .. ...|.  |.| |...   |. .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LDWDARLIIALGAAQGLEYLHHNCSPRIIHRDVKSSNILLDERFEVHLSDFGIAKSICSASTHTSTYVMGTIGYIDPEYARTSRLNE-KSDVYSFGIVLL
..      ..   ...|||.| .    |||||.| .||||||  .. ..|||.|. .        | . ||  |. ||       .  |.|..|.|..| 
FPE-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

ELITRQKAVDDEKNLHQWVLSHVNNKSVMEIVDQEVKDTCTDPNAIQKLIRLALLCAQKFPAQRPTMHDVVN--------VIL
|.....   .     .. .. ..                  .| |.. .||  |   || |..|||  .. .          .
EMLCGYPPFP-----QMQMMFKKIG----------------SPEAKD-FIRKCL---QKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAKf_k-1.AA TyrKc 637-903 22 1.7e-20 75.3 SMART 1-280 (280) Show / Hide 
Range on Protein: 637-903
Range on HMM: 1-280/280
Sequence Identity: 22% (67 aa)

LHERFLVGRGASSSVYKCTLKNGKKVAIKRLYNHYPQNVHEFETELATLGHI--KHRNLVSLYGYSLSS-------AGNLLFYDFMDNGSLWDILHGPVR
..     |.||   |||.|.|   .||.| | ..    . .|  |.  . ..  .| |.| |||. ...          ..   .|..|.| | |. . .
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

KVTLDWDARLIIALGAAQGLEYLHHNCSPRIIHRDVKSSNILLDERFEVHLSDFGIAKSICSA-------STHTSTY---VM--GTIGYIDPEYARTSRL
|  | ..  | ... .|.| ||||..   ..||||    |.|..|.. |  |||| .. | .        .. ...          |    ||  .... 
K--LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

NEKSDVYSFGIVLLELITRQKAVDDE-----KNLHQWVLSHVNNKSVMEIVDQ-----EVKDTCTDPNAIQKLIRLALLCAQKFPAQRPTMHDVVNVI
..||||.|||... |. |. .    .     ..  . |. .| .   |.. .              . . ... .. . | .  |..|||. ...  .
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQE-VIEYVKQGYRMPQPPNDYPMSF-------VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase IRAKf_k-1.AA DRK 877-905 27 0.107424 1.56 In-house 230-258 (258) Show / Hide 
Range on Protein: 877-905
Range on HMM: 230-258/258
Sequence Identity: 27% (8 aa)

KLIRLALLCAQKFPAQRPTMHDVVNVILT
| |.|   |    | .||.| ...  .  
KYIQLMNDCWNEDPQHRPSMQECLERLEA
Kinase IRAKf_k-1.AA Dicty4-Unclassified 872-903 31 0.120897 1.36 In-house 235-263 (263) Show / Hide 
Range on Protein: 872-903
Range on HMM: 235-263/263
Sequence Identity: 31% (10 aa)

PNAIQKLIRLALLCAQKFPAQRPTMHDVVNVI
.| ..|||     |    |  |||| ....  
DNFWKKLIK---WCWHNDPNKRPTMNQIIQYL
Kinase IRAKf_k-1.AA Pkinase_Tyr 890-903 28 0.769065 3.47 Pfam 257-270 (270) Show / Hide 
Range on Protein: 890-903
Range on HMM: 257-270/270
Sequence Identity: 28% (4 aa)

PAQRPTMHDVVNVI
|..|||. .... .
PEDRPTFSEIHEQL