Gene IRAKf_b (S.moellendorffii)
IRAKf_b
Species: S.moellendorffii
Alias: IRAKf_b
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| IRAKf_b.AA | Protein | None | 980 | None | Fasta, JSON |
| IRAKf_b.NA | RNA | None | 2943 | None | Fasta, JSON |
| IRAKf_b.kin_dom | Protein Kinase Domain | None | 201 | None | Fasta, JSON |
Protein domains of IRAKf_b.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| LRRNT_2 | IRAKf_b.AA | LRRNT_2 | 32-72 | 36 | 1.9e-13 | 46.61 | Pfam | 1-46 (46) | Show / Hide |
Range on Protein: 32-72 Range on HMM: 1-46/46 Sequence Identity: 36% (17 aa) WNDDVLGLIVFKADLHD-PR--RALASWSEDS--ASPCNWTGIQCS |||.. |. ||. |.| .. .|.||. .| ...|.|||. |. HNDDGQALLAFKSSLNDSDPHHGVLSSWNPSSSDSDCCSWTGVTCD |
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| LRR_1 | IRAKf_b.AA | LRR_1 | 125-148 | 33 | 0.001291 | 16.99 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 125-148 Range on HMM: 1-26/26 Sequence Identity: 33% (9 aa) SLRNLSLSH-N--ALSGPLPGASLASL .|. |.||. | |.| .| .. .| NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_1 | IRAKf_b.AA | LRR_1 | 101-123 | 40 | 0.001569 | 16.69 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 101-123 Range on HMM: 1-26/26 Sequence Identity: 40% (11 aa) HLQVLSLAR-N--NLSGSISPQ-IRVL .||.|.| . | ||.|.|.| . | NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_1 | IRAKf_b.AA | LRR_1 | 150-173 | 37 | 0.022192 | 12.61 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 150-173 Range on HMM: 1-26/26 Sequence Identity: 37% (10 aa) LLSLLDVSQ-N--SFSGSVPPELFANC | ||.| | ...|..||. | |. NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_TYP | IRAKf_b.AA | LRR_TYP | 148-172 | 36 | 0.107504 | 7.79 | SMART | 1-24 (24) | Show / Hide |
Range on Protein: 148-172 Range on HMM: 1-24/24 Sequence Identity: 36% (9 aa) LELLSLLDVSQNSFSGSVPPELFAN | | || | | . ..||..|.. LPNLRELDLSNNQL-THLPPGAFQG |
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| LRR_TYP | IRAKf_b.AA | LRR_TYP | 123-146 | 45 | 0.118616 | 7.44 | SMART | 1-24 (24) | Show / Hide |
Range on Protein: 123-146 Range on HMM: 1-24/24 Sequence Identity: 45% (11 aa) LKSLRNLSLSHNALSGPLPGASLA | .|| |.||.|.|. ||| LPNLRELDLSNNQLTHLPPGAFQG |
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| LRR_TYP | IRAKf_b.AA | LRR_TYP | 99-122 | 28 | 0.641994 | 1.43 | SMART | 1-24 (24) | Show / Hide |
Range on Protein: 99-122 Range on HMM: 1-24/24 Sequence Identity: 28% (7 aa) LDHLQVLSLARNNLSGSISPQI-RV | .|..|.| .|.| .. |.. . LPNLRELDLSNNQL-THLPPGAFQG |
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| LRR_1 | IRAKf_b.AA | LRR_1 | 176-198 | 33 | 0.000193 | 19.92 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 176-198 Range on HMM: 1-26/26 Sequence Identity: 33% (9 aa) SLRYVFLSG-N--QLEGDLPDS-IASC .|.. ||| | .|.|..|.| . .. NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_1 | IRAKf_b.AA | LRR_1 | 224-246 | 40 | 5.6e-05 | 21.83 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 224-246 Range on HMM: 1-26/26 Sequence Identity: 40% (11 aa) RLSSLDLSH-N--SLSGEIPPE-LGQC .| .||||. | .|.|.|||. . .. NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_TYP | IRAKf_b.AA | LRR_TYP | 222-246 | 44 | 0.002724 | 18.18 | SMART | 1-24 (24) | Show / Hide |
Range on Protein: 222-246 Range on HMM: 1-24/24 Sequence Identity: 44% (11 aa) LSRLSSLDLSHNSLSGEIPPELGQC |. | .||||.| | ..||.. |. LPNLRELDLSNNQL-THLPPGAFQG |
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| LRR_1 | IRAKf_b.AA | LRR_1 | 200-222 | 33 | 0.131504 | 9.87 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 200-222 Range on HMM: 1-26/26 Sequence Identity: 33% (9 aa) SLEALGASE-N--RLSGSIPAG-VGSL .|. | | | .|.|.|| . .| NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_1 | IRAKf_b.AA | LRR_1 | 248-270 | 40 | 0.004022 | 15.24 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 248-270 Range on HMM: 1-26/26 Sequence Identity: 40% (11 aa) MLVSLDLSY-N--LLSGEIPSF-LESL | .||||. | |.|.||. . .| NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_1 | IRAKf_b.AA | LRR_1 | 321-343 | 33 | 0.000345 | 19.02 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 321-343 Range on HMM: 1-26/26 Sequence Identity: 33% (9 aa) ALRRLYLHN-N--NLQGALPPT-LGGC |..|.| . | ||.| .|| . .. NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_TYP | IRAKf_b.AA | LRR_TYP | 319-343 | 40 | 0.012595 | 15.42 | SMART | 1-24 (24) | Show / Hide |
Range on Protein: 319-343 Range on HMM: 1-24/24 Sequence Identity: 40% (10 aa) MKALRRLYLHNNNLQGALPPTLGGC . .||.|.|.||.| .||| . .. LPNLRELDLSNNQL-THLPPGAFQG |
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| LRR_1 | IRAKf_b.AA | LRR_1 | 297-319 | 33 | 0.041935 | 11.63 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 297-319 Range on HMM: 1-26/26 Sequence Identity: 33% (9 aa) ELQELNLAE-N--DLGGTLPSS-IGSM ||.|.| | | |..|.| . .. NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_1 | IRAKf_b.AA | LRR_1 | 272-295 | 25 | 0.494614 | 7.83 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 272-295 Range on HMM: 1-26/26 Sequence Identity: 25% (7 aa) RLEVLRLPG-N--SFSGGVPEWIVTGF .|..| | | | ...| .|... .. NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_TYP | IRAKf_b.AA | LRR_TYP | 295-318 | 36 | 0.751364 | 0.87 | SMART | 1-24 (24) | Show / Hide |
Range on Protein: 295-318 Range on HMM: 1-24/24 Sequence Identity: 36% (9 aa) FPELQELNLAENDLGGTLPSSI-GS |.|.||.| | | .||. . .. LPNLRELDLSNNQL-THLPPGAFQG |
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| LRR_1 | IRAKf_b.AA | LRR_1 | 345-367 | 40 | 0.000748 | 17.83 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 345-367 Range on HMM: 1-26/26 Sequence Identity: 40% (11 aa) NLSTIDLSS-N--NFSGAIPDE-IFEL || ..|||. | |..| ||.. . | NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_TYP | IRAKf_b.AA | LRR_TYP | 345-367 | 34 | 0.732606 | 0.96 | SMART | 3-24 (24) | Show / Hide |
Range on Protein: 345-367 Range on HMM: 3-24/24 Sequence Identity: 34% (8 aa) NLSTIDLSSNNFSGAIPDEIFEL || . |||.|.. ..|...|. NLRELDLSNNQL-THLPPGAFQG |
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| LRR_1 | IRAKf_b.AA | LRR_1 | 368-390 | 22 | 29.932035 | 1.51 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 368-390 Range on HMM: 1-26/26 Sequence Identity: 22% (6 aa) ELESLALAM-N--SFSGGLPAA-LSSS |..| | | ...| .| . . NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_1 | IRAKf_b.AA | LRR_1 | 398-420 | 40 | 0.003945 | 15.27 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 398-420 Range on HMM: 1-26/26 Sequence Identity: 40% (11 aa) VIQSLDLSR-N--SLEGEIPPQ-VSGC .|.||||. | .|.|.||| .. NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_1 | IRAKf_b.AA | LRR_1 | 422-445 | 33 | 0.000921 | 17.51 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 422-445 Range on HMM: 1-26/26 Sequence Identity: 33% (9 aa) HLRSLNLGQ-N--GLSGNIPEELVAGL .|..|.|. | |.|.||.. .| NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_1 | IRAKf_b.AA | LRR_1 | 471-493 | 33 | 0.004731 | 14.99 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 471-493 Range on HMM: 1-26/26 Sequence Identity: 33% (9 aa) SLETLKLDD-N--ALVGIIPEE-LGNC .|..| |.. | |.| ||.. . |. NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_1 | IRAKf_b.AA | LRR_1 | 447-469 | 44 | 0.009984 | 13.84 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 447-469 Range on HMM: 1-26/26 Sequence Identity: 44% (12 aa) ELSSLDLGS-N--FLTGYIPRS-FGGS | .|||.. | |||.|| | | . NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_TYP | IRAKf_b.AA | LRR_TYP | 445-468 | 45 | 0.045113 | 10.88 | SMART | 1-24 (24) | Show / Hide |
Range on Protein: 445-468 Range on HMM: 1-24/24 Sequence Identity: 45% (11 aa) LSELSSLDLGSNFLTGYIPRSFGG |..| .|||..| || |. |.| LPNLRELDLSNNQLTHLPPGAFQG |
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| LRR_TYP | IRAKf_b.AA | LRR_TYP | 470-493 | 29 | 0.766284 | 0.8 | SMART | 2-24 (24) | Show / Hide |
Range on Protein: 470-493 Range on HMM: 2-24/24 Sequence Identity: 29% (7 aa) PSLETLKLDDNALVGIIPEELGNC |.|..| |..|.| .|... .. PNLRELDLSNNQL-THLPPGAFQG |
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| LRR_1 | IRAKf_b.AA | LRR_1 | 519-541 | 55 | 9e-06 | 24.56 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 519-541 Range on HMM: 1-26/26 Sequence Identity: 55% (15 aa) SLQSLDLSS-N--HLTGQIPTS-FAQL .||.||||. | .|||.|| | | .| NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_1 | IRAKf_b.AA | LRR_1 | 495-517 | 48 | 6.2e-05 | 21.67 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 495-517 Range on HMM: 1-26/26 Sequence Identity: 48% (13 aa) SLRYLDLSQ-N--NLTGGIPVE-LADL .|..|||| | |||| || . . | NLQHLDLSGCNCCNLTGHIPPSCF-NL |
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| LRR_TYP | IRAKf_b.AA | LRR_TYP | 517-540 | 45 | 0.021665 | 13.49 | SMART | 1-24 (24) | Show / Hide |
Range on Protein: 517-540 Range on HMM: 1-24/24 Sequence Identity: 45% (11 aa) LSSLQSLDLSSNHLTGQIPTSFAQ |..|..||||.|.|| | |. LPNLRELDLSNNQLTHLPPGAFQG |
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| LRR_1 | IRAKf_b.AA | LRR_1 | 543-567 | 35 | 0.138516 | 9.79 | Pfam | 1-26 (26) | Show / Hide |
Range on Protein: 543-567 Range on HMM: 1-26/26 Sequence Identity: 35% (10 aa) NLSLFNVSH-N--SLAGPIPSDGAFPLL || ..|. | .| | ||.. .| | NLQHLDLSGCNCCNLTGHIPPS-CF-NL |
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| Kinase | IRAKf_b.AA | TKL | 707-969 | 21 | 2e-61 | 210.39 | In-house | 1-364 (364) | Show / Hide |
Range on Protein: 707-969
Range on HMM: 1-364/364
Sequence Identity: 21% (81 aa)
IGRGGFGTVYKATLAA---------GRTVAVKKLSVPG-----------------------MVETQDEFEKRVQFL---GKIQHENLVNFQGYYFTPKL-
||.||||.|||... |..|||||... . |.. ....... . ...|.|.| | || . |.
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG
------------QLLIYDFVPNGNLHSKLHEQSVLPWELRFKVALGAAQGLCYLHHKCR-----PRVIHYNFKSSNVLLDDGFN--------------AR
......|.|.|.. || |..|.. ||..|.|..||| . | .|| . ||.|.|.|. .. .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCK
VSDYGLAKLLHSRDRFVVM----------------NKLQS-SLGYLAPEC---------------GCESFKVTEKCDVYGFGVVLLELITGKPPVE-YLE
..|.||.. .. . . . | .....|||. |..|. .|||||| ||.|| |..|...| . | .
ICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPY
NDVVIL---CDFVRSLADDGKPLLC------VDPKMVVYPEEEVMT-LIKLGLVCTSPVPANRPSMTEVVQIL
..... .. .|.|..... . | . .|.. ... ..|| | .. | .|||..|....|
MPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHH-K-M-CPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
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| Kinase | IRAKf_b.AA | IRAK | 702-969 | 24 | 6.3e-42 | 145.61 | In-house | 2-317 (317) | Show / Hide |
Range on Protein: 702-969
Range on HMM: 2-317/317
Sequence Identity: 24% (79 aa)
NKNSEIGRGGFGTVYKATLAAGR-TVAVKKLSVPGMVETQD---EFEK---RVQFLGKIQHENLVNFQGYYFTPKLQLLIYDFVPNGNLHSKLHEQSV--
.|. || ||||.||.. . ..||||| .... .| .. . ...|.|.| . || . . |.|.. ||| |. |. |
HKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQC
----LPWELRFKVALGAAQGLCYLHHKCRPR--VIHYNFKSSNVLLDDGFNARVSDYGLAKLL----HSRDRFV---VMNKLQSSLGYLAPECGC-ESFK
|.| |.....|.| |. .|| . .| .|| . ||.|.|||. |.. .| ||. |. . . .... .. |..|| . .
PPKPLSWHQRCSICWGTACGIQFLHQN-HPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQ
VTEKCDVYGFGVVLLELITGKPPVEYLENDVVILCDFVRSLADDGK--------------------PLLC------VDPKMVVYPEEEVMTLIKLGLVCT
| | ||| ||.||||..|| ..| . | | .. ... . | .|..| |.... . . . |.
LTKKTDVYSFGIVLLEVLTGCRAVYDDRPEHYYLKDLCEEIMEEWGHLDSCQSTLWVGVATDAWAAPRRMQIYEKFIDHRMPPCPPNMEKEMCQCACCCG
SPVPANRPSMTEVVQIL
..|..|..|.| |
HHRANRRCDMAWVMQQL
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| Kinase | IRAKf_b.AA | TKL-Unique | 705-899 | 31 | 1.4e-41 | 144.45 | In-house | 3-225 (290) | Show / Hide |
Range on Protein: 705-899 Range on HMM: 3-225/290 Sequence Identity: 31% (70 aa) SEIGRGGFGTVYKATLAAGRTVAVKKLSV-PGMV-ETQDEFEKRVQFLGKIQ-HENLVNFQGYYF----TPKLQLLIYDFVPNGNLHSKLH--------- . ||.||.|.|||.. .| ||.|.... . | .|||. | . |.. |.|.| . || . .|. .. ...| |.|.. || NKIGEGGYGQVYKGKW-RGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNN -EQSVLPWELRFKVALGAAQGLCYLHHKCRPRVIHYNFKSSNVLLDDG-----FNARVSDYGLAKLLHSR-DRFVVMN------KLQSSLGYLAPECGCE . . |....| | |. .|||..||||. | .|| . ||||.|.| . .|....| ||.|.. .. . .. .. ..|. ..||| . NNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRM S-FKVTEKCDVYGFGVVLLELITGK . .. .||.||| ||.|| |..|.| NFCQYSEKSDVYSFGIVLWEIATRK |
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| Pkinase | IRAKf_b.AA | Pkinase | 701-901 | 22 | 5.1e-33 | 117.82 | Pfam | 1-211 (293) | Show / Hide |
Range on Protein: 701-901 Range on HMM: 1-211/293 Sequence Identity: 22% (48 aa) LNKNSEIGRGGFGTVYKATLAAGRT-VAVKKLSVPGMVETQDEFEKR---VQFLGKIQHENLVNFQGYYFTPKLQLLIYDFVPNG----NLHSKLH--EQ . . . ||.|.||.|||.. . ||||...... . .|. | .| . ...|.| | . ... ... .. .....| |.. .. .. YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH SVL--PWELRFKVALGAAQGLCYLHHKCRPRVIHYNFKSSNVLLDDGFNA----RVSDYGLAKLLHSRDRFVVMNKLQSSLGYLAPECGCE-SFKVTEKC .. ... .... ..|| |.| . ..|| |..|.|.|. . ...| ||||.. . . |. . ...|.||| . . . . |. GCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEV-IRGGQYYGPKV DVYGFGVVLLELITGKPP |....|..| |...|.|| DMWSCGCILYEMLCGRPP |
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| Kinase | IRAKf_b.AA | TK | 701-969 | 13 | 7.8e-33 | 106.82 | In-house | 1-486 (486) | Show / Hide |
Range on Protein: 701-969
Range on HMM: 1-486/486
Sequence Identity: 13% (68 aa)
LNKNSEIGRGGFG---TVYKATLAAGR--------------------------TVAVKKLSVPGMVETQDEFE-----------------KRVQFLG-KI
. ..|.| || .|||... .. .|||| | . ...|. . ... .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG
QHENLVNFQGYYFTP------------KLQLLIYDFVPNGN----LHSKLHEQSV---------------------------------------------
.|.|.|.. |. . . . ... ..|.|. |.. |.. .
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY
-------------------------------LPWELRFKVALGAAQGLCYLHHK----CRPRVIHYNFKSSNVLLDDGFN-----------ARVSDYG--
|. . . .. .|.|. ||| | ....| . |.|.... . ....|.|
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS
------LAKLLHSRDRFVVMN-------------------KLQSSLG-----YLAPECGCESF--------KVTEKCDVYGFGVVLLELIT-G-KPPVEY
||. ..|.| .... ..|.| | ..|||| . | |.| ||. |||.. |. | | .|. ..
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGG
LENDVVIL----CDFVRSLADD-----------GKPLLCVDP---------KMVVYPEEEVMTLIKL-GLVCTSPVPANRPSMTEVVQIL
. |. |. .... | . | . . | .| |... ... . . | .. |. ||....... |
MSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRM-H-PPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
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| Kinase | IRAKf_b.AA | LRRK | 701-903 | 22 | 1.5e-29 | 101.75 | In-house | 1-284 (351) | Show / Hide |
Range on Protein: 701-903 Range on HMM: 1-284/351 Sequence Identity: 22% (67 aa) LNKNSEIGRGGFG-TVYKATLAA---------------------------GRTVAVKKLSVP---------------------------------GMVET | ....||||||| .||.|.. . .||.||. .. .. . LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA QDEFEKRVQFLGKIQHENLVNFQGYYFTPKLQLLIYDFVPNGNLHSKLH---EQS------VLPWELRFKVALGAAQGLCYLHHKCRPRVIHYNFKSSNV || . | . . .| |.|. |. . | .. ...|.|.|.. || . . ...| |. |.|| | |. || |...| .|| . || |. FREFRHEVWIMSHLNHPNIVSLKGFCIHP--LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYL-HSHNPPIIHRDLKSPNI LL---D---------DGFNARVSDYGLAK----LLHSRDRFVVMNKLQSSLGYLAPECGCES--FKVTEKCDVYGFGVVLLELITGK-PPVE || . . .| ..|.|. .... ...| |. |..|||. . ||| |.| ||..| ||.|.. .| . LLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNP-----GWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFD |
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| Kinase | IRAKf_b.AA | MLK | 701-901 | 25 | 3.2e-29 | 98.57 | In-house | 1-235 (291) | Show / Hide |
Range on Protein: 701-901 Range on HMM: 1-235/291 Sequence Identity: 25% (60 aa) LNKNSEIGRGGFGTVYKATLAAGR----TVAVKKLS---VPGMVET---QDEFEKRVQFLGKIQHEN----LVNFQGY-YFTPKLQLLIYDFVPNGNLHS .. || |.|| |.|.. . . .||||. ...| |..||. . | ...|.| . | | .|. ... ....| |.. IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN KLHEQS--------------VLPWELRFKVALGAAQGLCYLHHKCRPRVIHYNFKSSNVLLDD------GFNARVSDYGLAKLLHSRDRFVVMNKLQSSL ||... | . .. .. || |.|. ||| . .. .||. ||.|.|.|. . .....| |... .|... | . . .. VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC--TNMMSNAGTY GYLAPECG--CESFKVTEKCDVYGFGVVLLELITGKPP . ||| .. |..|||||. .|||| |..|.. | AWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVP |
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| Kinase | IRAKf_b.AA | S_TKc | 701-972 | 20 | 3.4e-29 | 104.24 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 701-972 Range on HMM: 1-231/231 Sequence Identity: 20% (58 aa) LNKNSEIGRGGFGTVYKATLAA-GRTVAVKKLSVPGMVETQDEFEKRVQFLGKIQHENLVNFQGYYFTPKLQLLIYDFVPN--GNLHSKLHEQSV----- . .||.|.||.|||.. || ||.|... . ... .| | | .|.|.|.. ... . . .. ..... |.|.. .... YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF -LPWELRFKVALGAAQGLCYLHHKCRPRVIHYNFKSSNVLLDDGFNARVSDYGLAKLLHSRDRFVVMNKLQSSLGYLAPECGCESFKVTE-KCDVYGFGV .| ... ...| |.| . .|| | .|.|||. . ..| |||..| . . .. |.||| . . |||.. .|. PFPE-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGC VLLELITGKPPVEYLENDVVILCDFVRSLADDGKPLLCVDPKMVVYPEEEVMTLIKLGLVCTSPVPANRPSMTEVVQ------ILELI .| |...|.|| . .. . . .. .|. .|. |. |..||. |. | . . . ILYEMLCGYPPFP----QMQMMFKKIG--------------------SPEAKDFIRKCLQ---KDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | IRAKf_b.AA | RIPK | 707-969 | 25 | 3.9e-28 | 92.95 | In-house | 1-290 (290) | Show / Hide |
Range on Protein: 707-969
Range on HMM: 1-290/290
Sequence Identity: 25% (75 aa)
IGRGGFGTVYKATLAAGRTVAVKKLSV-PGMVET-----QDEFEKRVQFLGKIQHENLVNFQGYYFTP------KLQLLIYDFVPNGNLHSKLHEQSV--
.|.||||.|.||. . .....|| . . . .. . . .. . |...|. | | . ||. . . .||.| || ..
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ
---LPWELRFKVALGAAQGLCYLHHKCRPRVIHYNFKSSNVLLDDGFNARVSDYGLAKLLHSR----DRF-----VVMNKLQS--SLGYLAPECGC--ES
.|| ||. . | |||| . | .|| | .|.|.| |.. ..| |||. . || | .... | |..|| ..
HHPDPWPLRCRMIHEISCGMCYLHSM-NPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDNK
FK---VTEKCDVYGFGVVLLELITGKPPVEYLENDVVILCDFVRSLADDGKPLLCVDPKMVVYPEE-EVMTLIKLGLVCTSPVPANRPSMTEVVQIL
||.| ||| |..|. |. |.| | | ... .|. ... . | |..| . .|| .. .|.| | . | .||. |.
KPIKVVTPKYDVYSFAIVMWEVLTQKHPYEDRKCMMMIMM----CCKQGHRP--CLQPVPEYWPEPPHCEQMIELMQRCWQQDPNDRPCFQECEEWT
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| Kinase | IRAKf_b.AA | Pkinase_Tyr | 701-901 | 25 | 6.8e-26 | 88.32 | Pfam | 1-214 (270) | Show / Hide |
Range on Protein: 701-901
Range on HMM: 1-214/270
Sequence Identity: 25% (55 aa)
LNKNSEIGRGGFGTVYKATLA-----AGRTVAVKKLSVPGMVET--QDEFEKRVQFLGKI-QHENLVNFQGYYF-TPKL--QLLIYDFVPNGNLHSKLHE
. .. ..|.| ||.|||.|. . .||||.| | | ...| . .. . .. .|.|.|.. | . ... ..|.|.|.. |..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK
----QSVLPWELRFKVALGAAQGLCYLHHKCRPRVIHYNFKSSNVLLDDGFNARVSDYGLAKLLHSRDRF-VVMNKLQSSLGYLAPECGCESFKVTEKCD
. |. . . .. |.|. ||. | || |.|..... ....| |||..... | .. . .|||| | |.| |
HREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPEC-INYGKFTTKSD
VYGFGVVLLELIT-GKPP
|. |||.. |..| |. |
VWSFGVLMWEIFTYGEQP
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| Kinase | IRAKf_b.AA | Dicty4-Unclassified | 701-901 | 32 | 1.1e-24 | 81.39 | In-house | 1-207 (263) | Show / Hide |
Range on Protein: 701-901 Range on HMM: 1-207/263 Sequence Identity: 32% (70 aa) LNKNSEIGRGGFGTVYKATLAAGRTVAVKKLSVPGMVETQ----DEFEKRVQFLGKIQHENLVNFQGYYFTP---KLQLLI-YDFVPNGNLHSKLH---- . .||.| | |.| |. |||||. . ..| | | || ||| ||| || | | . | | . ||| | IQIDQFIGKGHFSKVHKGNW-KGKDVAVKKFNE-NKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPS -EQSVLPWEL--RFKVALGAAQGLCYLHHKCRPRVIHYNFKSSNVLLDDGFNARVSDYGLAKLLHSRDRFVVMNKLQSSLGYLAPEC-GCESFKVTEKCD | . . |.|. |||. .|| . .|| ||||.|.| ||... | |.. | | .||| ||. . | | EQQQPIKLDDTLIIKYAFDIAQGMQHLHTR---NFIHRDIKSSNILMDKHFNIKIADFGISRVI---DFNFNMTTIAGTPKWESPECLMHESY--NQKSD VYGFGVVLLELITGKPP || ....| ||.|| | VYSYAMMLYELATGDEP |
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| Kinase | IRAKf_b.AA | Dicty4 | 701-847 | 35 | 6.1e-24 | 76.87 | In-house | 1-162 (277) | Show / Hide |
Range on Protein: 701-847 Range on HMM: 1-162/277 Sequence Identity: 35% (59 aa) LNKNSEIGRGGFGTVYKATLAAGRTVAVKKL--SVPGM-VETQDEFEKRVQFLGKIQHENLVNFQGYYF----TPKLQLLIYDFVPNGNLHSKLHE---- .|. ..||.|.||.|||.| | |||||| . .. || | | ..||.| |.. | |. .| . ..| |||.| || INIEQRIGKGSFGEVYKGTW-RGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSE --QSV-LPWELRFK---VALGAAQGLCYLHHKCRPRVIHYNFKSSNVLLDDGFNARVSDYGLAK ||. |.|.|. . |. ||.|. .|| | |..|| ||.| | |. ... |.| ||.. QQQSIKLDWPLIKRAMRMAFDAARGMNWLHC-CNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQ |
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| Kinase | IRAKf_b.AA | LISK | 706-849 | 31 | 2.6e-22 | 69.13 | In-house | 1-155 (296) | Show / Hide |
Range on Protein: 706-849 Range on HMM: 1-155/296 Sequence Identity: 31% (49 aa) EIGRGGFGTVYKATLA-AGRTVAVKKLSV----PGMVETQDEFEKRVQFLGKIQHENLVNFQGYYFT-PKLQLLIYDFVPNGNLHSKLH-EQS---VLPW |||.|.|| ||| |. |. .|.|... | |.| ... || . ...| | |.| | . . .. .. |.|| |. . . .||| EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW ELRFKVALGAAQGLCYLHHKCRPRVIHYNFKSSNVLLD----DGFNARVSDYGLAKLL ..| | ||. |.|. ||| .. .|| || |.|.. ......| | |.|... PQRVKIALDIACGMSYLHSMN---IIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMM |
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| Kinase | IRAKf_b.AA | TyrKc | 701-969 | 22 | 4.9e-22 | 80.46 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 701-969 Range on HMM: 1-280/280 Sequence Identity: 22% (65 aa) LNKNSEIGRGGFGTVYKATLAAGRTVAVKKLSVPGMVETQDEFEKRVQFLGKI--QHENLVNFQGYYFTP-------KLQLLIYDFVPNGNLHSKLHEQS . .. ..|.| ||.|||.|. ..||||.| . .| . . . |. .|.|.|.. |. .. . ... ..|.|.|.. |.. ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR V-LPWELRFKVALGAAQGLCYLHHKCRPRVIHYNFKSSNVLLDDGFNARVSDYGLAKLLHSR-------DRFVVMN--KLQ--SSLGYLAPECGCESFKV |... . .. .|.| |||.| ..|| |.|..... ...|| ||.. ... | ... . .|||| | PKLCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKF TEKCDVYGFGVVLLELIT-GKPPVEYLENDVVILCDFVRSLADDGKPLLCVDP----KMVVYPEEEVMTLIKLGLVCTSPVPANRPSMTEVVQIL |.| ||. |||.. |. | |..| . . .. . |. . ..|. . . . | .|. ...| | |..||...|..... TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSF-VCCPDEMYQIMKQ---CWHEDPEDRPTFSEIHECF |
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| Kinase | IRAKf_b.AA | LISK | 880-905 | 44 | 1.2e-08 | 23.95 | In-house | 217-243 (296) | Show / Hide |
Range on Protein: 880-905 Range on HMM: 217-243/296 Sequence Identity: 44% (12 aa) TEKCDVYGFGVVLLELITGKPPVE-YL .|.|||. ||.||.|.||.. . . |. DESCDVFSFGIVLCEIITRVKADPDYW |
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| Kinase | IRAKf_b.AA | MLK | 951-969 | 42 | 0.000108 | 12.36 | In-house | 273-291 (291) | Show / Hide |
Range on Protein: 951-969 Range on HMM: 273-291/291 Sequence Identity: 42% (8 aa) CTSPVPANRPSMTEVVQIL | .. |..|||. ..||.| CWNQDPHKRPSFRQIVQHL |
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| Kinase | IRAKf_b.AA | Dicty4 | 956-971 | 44 | 0.000218 | 10.74 | In-house | 260-277 (277) | Show / Hide |
Range on Protein: 956-971 Range on HMM: 260-277/277 Sequence Identity: 44% (8 aa) PANRPSMTEVVQI--LEL | .|||. |..|. || PQHRPSFEEIIQRRILEH |
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| Kinase | IRAKf_b.AA | Dicty4 | 880-901 | 54 | 0.000584 | 9.29 | In-house | 195-216 (277) | Show / Hide |
Range on Protein: 880-901 Range on HMM: 195-216/277 Sequence Identity: 54% (12 aa) TEKCDVYGFGVVLLELITGKPP .|| ||| || || |. |.. | NEKADVYSFGIVLWEILTRQEP |
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| Kinase | IRAKf_b.AA | LRRK | 951-971 | 28 | 0.000933 | 9.15 | In-house | 331-351 (351) | Show / Hide |
Range on Protein: 951-971 Range on HMM: 331-351/351 Sequence Identity: 28% (6 aa) CTSPVPANRPSMTEVVQILEL | . | .||.....|..|. CWQHDPKKRPHFSQIVKRLSQ |
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| Kinase | IRAKf_b.AA | LISK | 944-969 | 42 | 0.00507 | 5.43 | In-house | 271-296 (296) | Show / Hide |
Range on Protein: 944-969 Range on HMM: 271-296/296 Sequence Identity: 42% (11 aa) LIKLGLVCTSPVPANRPSMTEVVQIL ...| . |.. | |||| .|.||.| FLDLCFDCCKYDPKNRPSFKEIVQWL |
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| Kinase | IRAKf_b.AA | Dicty4-Unclassified | 951-969 | 36 | 0.009752 | 5.16 | In-house | 245-263 (263) | Show / Hide |
Range on Protein: 951-969 Range on HMM: 245-263/263 Sequence Identity: 36% (7 aa) CTSPVPANRPSMTEVVQIL | . | ||.| ...| | CWHNDPNKRPTMNQIIQYL |
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| Kinase | IRAKf_b.AA | Pkinase_Tyr | 956-969 | 35 | 0.17234 | 5.67 | Pfam | 257-270 (270) | Show / Hide |
Range on Protein: 956-969 Range on HMM: 257-270/270 Sequence Identity: 35% (5 aa) PANRPSMTEVVQIL |..||...|....| PEDRPTFSEIHEQL |
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