Gene IRAKg_a-1 (S.moellendorffii)

IRAKg_a-1

Species: S.moellendorffii
Alias: IRAKg_a-1
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAKg

Sequence

Name Sequence Type Origin Length Description Download
IRAKg_a-1.AA Protein None 827 None Fasta, JSON
IRAKg_a-1.NA RNA None 2484 None Fasta, JSON
IRAKg_a-1.kin_dom Protein Kinase Domain None 214 None Fasta, JSON

Protein domain

Protein domains of IRAKg_a-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
B_lectin IRAKg_a-1.AA B_lectin 73-165 29 1.6e-18 65.2 Pfam 1-129 (137) Show / Hide 
Range on Protein: 73-165
Range on HMM: 1-129/137
Sequence Identity: 29% (38 aa)

QQVLVWDTAAPA----------SRAGAILQLSS-DGSLAVRDGA---ST--TSWT----SGATGAS--SGQLQESGNLALR-NSS--GQVVWSS--FDHP
.|  || .|                .. |.... ||.| . ||.   |.     |    ||...|.  . |.|.|||| |. ...  . |.|.|  ||||
NQTVVW-VANRDLTGNPVTDSSNNGNYTLTMQNRDGNLVLYDGGNGGSVRPVWSTNNNTSGSGSANNCRAQMQDSGNLVLYDDNNDSNNVLWQSNTFDHP

SSTLLPGQFLPR------GRN----LTSRA
. |.|||. | .      . |    |||..
TDTWLPGMKLGWDNNVTIYMNWIGYLTSWK
B_lectin IRAKg_a-1.AA B_lectin 25-145 25 1.1e-17 65.96 SMART 1-126 (126) Show / Hide 
Range on Protein: 25-145
Range on HMM: 1-126/126
Sequence Identity: 25% (35 aa)

QDQFASGQTIATAGAAASISSGSFSLGFAPSPRSPGEFELGIWYRADS--QQVLVWDTAA-PASRAG-----AILQLSSDGSLAVRDGASTTSWTSGAT-
.    ||||. . .   ..  |.|...          . .||||   |  |.  || ...  .. .      . | ..||| | . |   .. | |. | 
DNTLSSGQTLVSGNSLFEFYLGFFTFIMQ--------WCNGIWYKNISNKQRTVVWVAQPNRDNPVHDGNNSCYLTMQSDGNLVIYD--NRPVWSSNTTR

--GASSGQLQESGNLALRNSS----GQVVWSSFDHP
  | .. .||..||. .....    | ..|.|||||
NNGNYVAVLQDDGNFVIYDPDDNDSGNFIWQSFDHP
B_lectin IRAKg_a-1.AA B_lectin 166-210 28 13.791517 0.15 Pfam 24-75 (137) Show / Hide 
Range on Protein: 166-210
Range on HMM: 24-75/137
Sequence Identity: 28% (15 aa)

GGYTLTMDQ-SGNLTLRWRS---AQ--YWSS-DTDGSGNSSIPTNAVVDVNG
|.|||||.   ||| |   .    .   ||. ..  ...|.  . |.   .|
GNYTLTMQNRDGNLVLYDGGNGGSVRPVWSTNNNTSGSGSANNCRAQMQDSG
S_locus_glycop IRAKg_a-1.AA S_locus_glycop 235-277 37 7.3e-08 29.05 Pfam 55-99 (117) Show / Hide 
Range on Protein: 235-277
Range on HMM: 55-99/117
Sequence Identity: 37% (17 aa)

RLTLDDDGNLRLYT--LIEAVWSARWQAVSDQCQVYNYCGNYGIC
|.|.. .| |  .|       |   | | .||| .|. ||.||.|
RFTMSSEGYLQRFTWNPNSQDWNLFWYAPKDQCDYYRRCGPYGYC
B_lectin IRAKg_a-1.AA B_lectin 235-256 39 0.546152 4.97 Pfam 27-54 (137) Show / Hide 
Range on Protein: 235-256
Range on HMM: 27-54/137
Sequence Identity: 39% (11 aa)

RLTLDD-DGNLRLYTLI---EA--VWSA
.||... |||| ||      .   |||.
TLTMQNRDGNLVLYDGGNGGSVRPVWST
Kinase IRAKg_a-1.AA TKL 491-773 20 1.1e-56 194.69 In-house 1-364 (364) Show / Hide 
Range on Protein: 491-773
Range on HMM: 1-364/364
Sequence Identity: 20% (79 aa)

IGEGGFGPVYKGSLA-LPVSK------TAIAVKKLEG---IFQGE-------------------------KEFRTEVATIGSTHHMNLMRLVGFCAEGAA
||.|||| |||| .   .. |      . .||||.      .  .                         .... |.  . ...| |. ...|.| ..  
IGSGGFGEVYKGKWRGWGG-KCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPC

T------------RLLVYEFLPNGS-LDRFLFQPLAPGEDEDDSYQEARPSLDWPTRFKIALGTARALAYLHE----ECREP--IVHCDLKPENILLDDS
.              .|.|. |.|| |....                      |. |...||..||...|||      |. .  |.|.|||..|||.|. 
GCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------------------WHQRCRWALDIARGMNYLHSMNPKWCT-KPPIIHRDLKSKNILVDEN

FA--------------PKVSDFGLARLIDEG------------------NARNLTTVRGTRGYMAPEWLANM----------------PITAKSDVYSYG
.               .|..||||.| ...                   |. .. |..|| ..|||| | ..                . . |.||||.|
WTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFG

MVLLELVGGRRNFDTCRAVPRGMQRYPAYLYRELEAG--RLEGAVD------ERMYRADVDGVQLERVVKVAFWCIQDVASARPVMSKVVQML
.|| |.. ..| ..     |. .|. | .      ..  .|   ..      . .         .... | . .| .  ...|| ...... |
IVLWEILTRCRPYYDYPYMPMIFQD-P-FEEMFMMVCDKGLRPPIPPIWQNHH-K-M-CPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Pkinase IRAKg_a-1.AA Pkinase 485-698 26 8e-49 173.32 Pfam 1-209 (293) Show / Hide 
Range on Protein: 485-698
Range on HMM: 1-209/293
Sequence Identity: 26% (62 aa)

YNFQTRIGEGGFGPVYKGSLALPVSKTAIAVKKLEGIFQGEKEFRT-----EVATIGSTHHMNLMRLVGFCAEGAATRLLVYEFLPNG----SLDRFLFQ
| .  .||.|.|| |||.           |||...   . ... .|     |..   . .| |  || ... .      .| |....|    .| ...  
YHIGRKIGSGSFGCVYKCHHKGTGK--IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYIST

PLAPGEDEDDSYQEARPSL--DWPTRFKIALGTARALAYLHEECREPIVHCDLKPENILLDDSFAP----KVSDFGLARLIDEGNARNLTTVRGTRGYMA
             ... ..  .. .  .... ..|.|.|.|..    |.|.||||||||.|.   .    |..|||||...|. | . .||. ||..|||
-------------WRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMA

PEWLA-NMPITAKSDVYSYGMVLLELVGGR
||..  . ... |.|..|.| .| |.. ||
PEVIRGGQYYGPKVDMWSCGCILYEMLCGR
Kinase IRAKg_a-1.AA Dicty4 485-695 33 1.8e-36 119.27 In-house 1-211 (277) Show / Hide 
Range on Protein: 485-695
Range on HMM: 1-211/277
Sequence Identity: 33% (75 aa)

YNFQTRIGEGGFGPVYKGSLALPVSKTAIAVKKL----EGIFQGE-KEFRTEVATIGSTHHMNLMRLVGFCA---EGAATRLLVYEFLPNGSLDRFLFQ-
.|.. |||.|.|| ||||.       .. |||||    .. .. . .||| ||.  ..  | |.  . | |        . . | |..| |.| . |   
INIEQRIGKGSFGEVYKGTWRG----KEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDK

PLAPGEDEDDSYQEARPSLDWPTRFK---IALGTARALAYLHE-ECREPIVHCDLKPENILLDDSFAPKVSDFGLARLIDEGN--ARNLTTVRGTRGYMA
|         | |  . .||||.. .   .|. .|| ...||.  ..  |.| |||. |.| |...  ||.||||.... ..     |..|. || ..||
P---------SEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV--IIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMA

PEWLANMPITAKSDVYSYGMVLLELV
|| ... | . |.||||.|.|| |..
PEVMMHQPYNEKADVYSFGIVLWEIL
Kinase IRAKg_a-1.AA LRRK 485-702 24 1.4e-35 123.37 In-house 1-284 (351) Show / Hide 
Range on Protein: 485-702
Range on HMM: 1-284/351
Sequence Identity: 24% (74 aa)

YNFQTRIGEGGFG-PVYKGSLALP------------------------VSKTAIAVKKLEG--------------------------------------I
  ..  ||.|||| .||.. .  .                         . . .|.||..                                       .
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

FQGEKEFRTEVATIGSTHHMNLMRLVGFCAEGAATRLLVYEFLPNGSLDRFLF---Q-PL--APGEDEDDSYQEARPSLDWPTRFKIALGTARALAYLHE
|.   ||| ||. . . .| |.. |.||| .  .   .| |..|.|.|..||.   | ..   .            ....| .. ||||  |....||| 
FR---EFRHEVWIMSHLNHPNIVSLKGFCIHPLC---MVMEYAPHGDLYHFLHNKKQDGFHFMK------------AHISWMLKLKIALQIAKGMEYLH-

ECREPIVHCDLKPENILLDDSFAP------------KVSDFGLAR--LIDEGNARNLTTVRGTRGYMAPEWLANM---PITAKSDVYSYGMVLLELVGGR
 .. ||.|.|||..||||  | ..            |..|||. |   ..   ...  .. |. |.|||| . ..     | |.|.||.||.| ||. ..
SHNPPIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAK--GCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQ

-RNFD
 . ||
HHPFD
Kinase IRAKg_a-1.AA TKL-Unique 487-695 30 1.1e-33 116.18 In-house 1-222 (290) Show / Hide 
Range on Protein: 487-695
Range on HMM: 1-222/290
Sequence Identity: 30% (69 aa)

FQTRIGEGGFGPVYKGSLALPVSKTAIAVKKL--EGIFQGEKEFRTEVATIGSTH-HMNLMRLVGFCAE---GAATRLLVYEFLPNGSLDRFLFQPLAPG
|   |||||.|.||||    . ...|| ....  .  .. ..||. || ..   | | |. ...|.|.     .. . .| |..| |||.  | | .   
FWNKIGEGGYGQVYKG--KWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNN

EDEDDSYQEARPSLDWPTRFKIALGTARALAYLHEECREPIVHCDLKPENILLDDS-----FAPKVSDFGLARLIDEGNARNLT--------TVRGTRGY
    ...      |..  | |.|.  |... ||| .    | |.|||. |.|.|       .  |..||||... .  |. ...        |. |.  .
NNNNNNCK-----LNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRW

MAPEWLAN--MPITAKSDVYSYGMVLLELV
|||| | .    .. ||||||.|.|| |..
MAPEVLRMNFCQYSEKSDVYSFGIVLWEIA
Kinase IRAKg_a-1.AA TK 485-773 15 6.2e-32 103.75 In-house 1-486 (486) Show / Hide 
Range on Protein: 485-773
Range on HMM: 1-486/486
Sequence Identity: 15% (78 aa)

YNFQTRIGEGGFG---PVYKGSLALPV-------------------------SKTAIAVKKLEGIFQGEKEFR----------------TEVATIGS--T
  .   .||| ||    |||| .  .                           ..|....|..   . | .|                  | .   .   
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

HHMNLMRLVGFCAEGAAT-----------RLLVYEFLPNGS----LDRFLFQPLAPGEDEDDSYQE----------------------------------
|| |. ||.| | .|.              ..| |. |.|.    |. .| .   .. .| |....                                  
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

---------------------------ARPSLDWPTRFKIALGTARALAYLHEE----CREPIVHCDLKPENILLDDSFA-----------PKVSDFG--
                            .  |. ...  ...  |....|||.         .|| ||   |.|....              |..|||  
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

------LARLIDEGNARNLTTVRGTRG-------------------------YMAPEWLA---------NMPITAKSDVYSYGMVLLELVGGRRNFDTCR
      ||| |...     .. .||..                         .|||| |.         .   | ||||.|.| .. |.      |  ..
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEI------FTYGQ

AVPRG-MQR-------YPAYLYRELEAG-------RLEGAVDERMYRADVDGVQL-------------ERVVKVAFWCIQDVASARPVMSKVVQML
. . | |         ... ... |..|       . . .| .|| ..  ..                | .  .   | .  .. || .| ....|
EPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGL-N-EVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase IRAKg_a-1.AA Dicty4-Unclassified 486-697 33 8.9e-32 106.08 In-house 2-204 (263) Show / Hide 
Range on Protein: 486-697
Range on HMM: 2-204/263
Sequence Identity: 33% (75 aa)

NFQTRIGEGGFGPVYKGSLALPVSKTAIAVKKL-EGIFQGE----KEFRTEVATIGSTHHMNLMRLVGFCAEG---AATRLLVYEFLPNGSLDRFLF-QP
     ||.| |  |.||          .||||. |. |.      ..|. ||.  ||  | ||... | |       .|   | ||.. | |      .|
QIDQFIGKGHFSKVHKGNWK----GKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKP

LAPGEDEDDSYQEARPSLDWPTRFKIALGTARALAYLHEECREPIVHCDLKPENILLDDSFAPKVSDFGLARLIDEGNARNLTTVRGTRGYMAPEWLANM
         | |.   .||     |.|.  |. ...||   |. ..| |.|  |||.|  |  |. |||..| ||  .  |.||. ||    .|| |   
---------SEQQQPIKLDDTLIIKYAFDIAQGMQHLH--TRN-FIHRDIKSSNILMDKHFNIKIADFGISRVID--FNFNMTTIAGTPKWESPECLMHE

PITAKSDVYSYGMVLLELVGG
  . |||||||.|.| ||. |
SYNQKSDVYSYAMMLYELATG
Kinase IRAKg_a-1.AA IRAK 592-699 40 1.8e-31 108.85 In-house 104-222 (317) Show / Hide 
Range on Protein: 592-699
Range on HMM: 104-222/317
Sequence Identity: 40% (48 aa)

PSLDWPTRFKIALGTARALAYLHEEC-REPIVHCDLKPENILLDDSFAPKVSDFGLARLI--DEGNARNLT------TVRGTRGYMAPEWLA--NMPITA
. | |..|..|..|||... .||.     || | | |. |||||. | || .||||.|     ... .         .||||  ||.|| .      .| 
KPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQLTK

KSDVYSYGMVLLELVGGRR
|.|||| | ||||.. |.|
KTDVYSFGIVLLEVLTGCR
Kinase IRAKg_a-1.AA LISK 596-699 30 9.5e-29 90.38 In-house 100-237 (296) Show / Hide 
Range on Protein: 596-699
Range on HMM: 100-237/296
Sequence Identity: 30% (43 aa)

WPTRFKIALGTARALAYLHEECREPIVHCDLKPENILLDDS----FAPKVSDFGLARLIDEGN--------------------------------ARN--
|| | ||||. |....|||. .   |.| |||  |.|....    .  || |||.||..|. |                                 |.  
WPQRVKIALDIACGMSYLHSMN---IIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESDPCMDNDMPMKRKIPKKCMNQRKRR

LTTVRGTRGYMAPEWLANMPITAKSDVYSYGMVLLELVGGRR
.| . ||   |||| |  .  . ..||.|.|.||.|......
MTIC-GTPYWMAPEMLLGQSYDESCDVFSFGIVLCEIITRVK
Kinase IRAKg_a-1.AA MLK 485-695 26 4.8e-28 94.45 In-house 1-230 (291) Show / Hide 
Range on Protein: 485-695
Range on HMM: 1-230/291
Sequence Identity: 26% (63 aa)

YNFQTRIGEGGFGPVYKGSLALPV-SKTAIAVKKLEGIF-----QG--EKEFRTEVATIGSTHHMN----LMRLVGFCAEGAATRLLVYEFLPNGSLDRF
 .|.. ||.|.|| |.||       .   .|||. .  .      .   ..|..|.       | |      ...| |..     ..| |....||| ..
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LFQPLAPGEDEDDSYQEAR--PSLDWPTRFKIALGTARALAYLHEECREPIVHCDLKPENILLDD------SFAPKVSDFGLARLIDEGNARNLTTVRGT
|      ..|      . .     |    ...||  ||...|||.. . ||.| |||. |||.|.          |..|||..| . .    | .  .||
LHGARSKWMDAN---HNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGT

RGYMAPEWL---ANMPITAKSDVYSYGMVLLELV
  .|||| .    . . . |.||.|.|.|| |..
YAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEML
Kinase IRAKg_a-1.AA CZAK 485-698 30 1.4e-27 97.35 In-house 1-219 (279) Show / Hide 
Range on Protein: 485-698
Range on HMM: 1-219/279
Sequence Identity: 30% (71 aa)

YNFQTRIGEGGFGPVYKGSLALPVSKTAIAVKKLEGI-FQGEKE------FRTEVATIGSTHHMNLMRLVGFCAEGA-ATRLLVYEFLPNGSLDRFLFQP
  |   ||.| || |||.        . .|.|..  . |    |      |  ||. .    | | .  .| | |.    .  | |.   |||.|.|   
LKFGQTIGQGFFGEVYKAYWR----GKDVAIKIIHRNQFRNKDENKEENMFQKEVSIMSKLCHPNCVQFLGACSEDGPNHHCIVMEWMGGGSLRRLL---

LAPGEDEDDSYQEARPSLDWPTRFKIALGTARALAYLHEECRE-PIVHCDLKPENILLDDSFA-------------PKVSDFGLARLIDEGNARNLTTVR
     ..  .| .  |.| |    ..|.  ||   |||   .. ||.| ||   |||||.|                |..|||| |.  |. .   |   
-----TDHYFYHKQNPHLQW----NMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDHSYTPKNPVVSSRQDIICKINDFGLSREMMEQ-PFEMTQTM

GTRGYMAPEWLANMPITAKSDVYSYGMVLLELVGGR
|   .||||       | |.||||.||.| ... ..
GCLCWMAPECFKGENYTEKVDVYSFGMILWCIITCD
Kinase IRAKg_a-1.AA Pkinase_Tyr 485-695 28 1.7e-26 90.38 Pfam 1-208 (270) Show / Hide 
Range on Protein: 485-695
Range on HMM: 1-208/270
Sequence Identity: 28% (63 aa)

YNFQTRIGEGGFGPVYKGSLA--LPVSKTAIAVKKLEGIFQGE----KEFRTEVATIGST-HHMNLMRLVGFCAEGAAT--RLLVYEFLPNGSLDRFLFQ
  |   .||| || |||| .       |.  |||.|      |    ..|  |...  .  || |. ||.| | .       ..| |. |.|.|. .| .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

PLAPGEDEDDSYQEARPSLDWPTRFKIALGTARALAYLHEECREPIVHCDLKPENILLDDSFAPKVSDFGLARLIDEGNARNLTTVRGTRG----YMAPE
.            | ...|. ..  ....  |....||..     ..| ||   |.|.....  |..||||||.| .      ...||        ||||
HR-----------EDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYY-YRKRGGGKLPIKWMAPE

WLANMPITAKSDVYSYGMVLLELV
 ....  | ||||.|.| .. |..
CINYGKFTTKSDVWSFGVLMWEIF
Kinase IRAKg_a-1.AA S_TKc 485-773 23 2e-24 88.42 SMART 1-231 (231) Show / Hide 
Range on Protein: 485-773
Range on HMM: 1-231/231
Sequence Identity: 23% (70 aa)

YNFQTRIGEGGFGPVYKGSLALPVSKTAIAVKKLEGIFQGEKEFRTEVATIGSTHHMNLMRLVGFCAEGAATRLLVYEFLPN--GSLDRFLFQPLAPGED
| .   ||.|.|| |||.      ..   |.|..       . .| |..   . || |. .| ... .      .| |....  |.| ... .   .| .
YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

EDDSYQEARPSLDWPTRFKIALGTARALAYLHEECREPIVHCDLKPENILLDDSFAPKVSDFGLARLIDEGNARNLTTVRGTRGYMAPEWLANMPITA-K
   .  .||         ...  ...||.|.|.     |.|.||||||||||.    |..||||||..        ||. ||. ||||| |   . .  |
FPFPE-HAR---------FYMYQICCALEYCHSHG---IIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCK

SDVYSYGMVLLELVGGRRNFDTCRAVPRGMQRYPAYLYRELEAGRLEGAVDERMYRADVDGVQLERVVKVAFWCIQDVASARPVMSKVVQ---------M
.|..| | .| |.. |.  |.            .. ... .                       . .      | |   . ||   .. |          
CDWWSCGCILYEMLCGYPPFP-----------QMQMMFKKIG---------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPW

L
.
F
Kinase IRAKg_a-1.AA TyrKc 485-773 21 1e-19 72.73 SMART 1-280 (280) Show / Hide 
Range on Protein: 485-773
Range on HMM: 1-280/280
Sequence Identity: 21% (70 aa)

YNFQTRIGEGGFGPVYKGSLALPVSKTAIAVKKLEGIFQGEKEFRTEVATIGST--HHMNLMRLVGFCAEGA------ATRLLVYEFLPNGSLDRFLFQP
  .   .||| || |||| .      .  |||.|      ...|. |     .   || |. ||.| | ..          ..| |. |.|.|. .|  .
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

LAPGEDEDDSYQEARPSLDWPTRFKIALGTARALAYLHEECREPIVHCDLKPENILLDDSFAPKVSDFGLARLIDEG----NARNLTTVR---GTRG---
                 | ...  ....  |.  .|||.    ...| ||   |.|... .  |.|||||.| |...     .    ...   |...   
RPK--------------LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLP

--YMAPEWLANMPITAKSDVYSYGMVLLELV-------GG-----RRNFDTCRAVPRG-MQRYPAYLYRELEAGRLEGAVDERMYRADVDGVQ-LERVVK
   |||| .     | ||||.|.| .. |.         |       |..  . | .| . . |.. | ..                    |   . . .
IRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-PMS----------------F--VCCPDEMYQ

VAFWCIQDVASARPVMSKVVQML
.  .| .  .. || .| ... .
IMKQCWHEDPEDRPTFSEIHECF
Kinase IRAKg_a-1.AA IRAK 485-569 34 2.5e-12 40.13 In-house 1-90 (317) Show / Hide 
Range on Protein: 485-569
Range on HMM: 1-90/317
Sequence Identity: 34% (33 aa)

YNFQTRIGEGGFGPVYKGSLALPVSKTA--IAVKKLE-----GIFQGEKEFRT---EVATIGSTHHMNLMRLVGFCAEGAATRLLVYEFLPNGSL
..   |||||||| ||.| .    . |.   |||||       . . ...|..   |. .  . .| |.  | |.|.|.     |||...|||||
FHKDNRIGEGGFGCVYRGQW----KNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCH-CLVYPYMPNGSL
Kinase IRAKg_a-1.AA LISK 490-504 60 0.000361 9.22 In-house 1-15 (296) Show / Hide 
Range on Protein: 490-504
Range on HMM: 1-15/296
Sequence Identity: 60% (9 aa)

RIGEGGFGPVYKGSL
 ||.|.|| ||||..
EIGKGFFGKVYKGTH