Gene IRAKg_a-2 (S.moellendorffii)

IRAKg_a-2

Species: S.moellendorffii
Alias: IRAKg_a-2
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAKg

Sequence

Name Sequence Type Origin Length Description Download
IRAKg_a-2.AA Protein None 828 None Fasta, JSON
IRAKg_a-2.NA RNA None 2487 None Fasta, JSON
IRAKg_a-2.kin_dom Protein Kinase Domain None 214 None Fasta, JSON

Protein domain

Protein domains of IRAKg_a-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
B_lectin IRAKg_a-2.AA B_lectin 73-175 28 1.2e-19 69.06 Pfam 1-137 (137) Show / Hide 
Range on Protein: 73-175
Range on HMM: 1-137/137
Sequence Identity: 28% (40 aa)

QQVLVWDTAAPA----------SRPGAILELSS-DGSLAVRDGA---SI--TSWT----SGATGAS--SGQLQESGNLALR-NSS--GQVVWSS--FDHP
.|  || .|                .. |.... ||.| . ||.   |.     |    ||...|.  . |.|.|||| |. ...  . |.|.|  ||||
NQTVVW-VANRDLTGNPVTDSSNNGNYTLTMQNRDGNLVLYDGGNGGSVRPVWSTNNNTSGSGSANNCRAQMQDSGNLVLYDDNNDSNNVLWQSNTFDHP

SSTLLPGQFLSR------GRN----LTSRAGGYSLAMDQS
. |.|||. | .      . |    |||.. . .  .|.|
TDTWLPGMKLGWDNNVTIYMNWIGYLTSWKSNTN--YDPS
B_lectin IRAKg_a-2.AA B_lectin 25-145 25 8.8e-18 66.31 SMART 1-126 (126) Show / Hide 
Range on Protein: 25-145
Range on HMM: 1-126/126
Sequence Identity: 25% (35 aa)

QDQFASGQTIATAGAATSVSSGSFSLGFAPSPRSPGEFELGIWYRADP--QQVLVWDTAA----PASR--PGAILELSSDGSLAVRDGASITSWTSGAT-
.    ||||. . .  ...  |.|...          . .||||   .  |.  || ...    |..   . . |...||| | . |   .. | |. | 
DNTLSSGQTLVSGNSLFEFYLGFFTFIMQ--------WCNGIWYKNISNKQRTVVWVAQPNRDNPVHDGNNSCYLTMQSDGNLVIYD--NRPVWSSNTTR

--GASSGQLQESGNLALRNSS----GQVVWSSFDHP
  | .. .||..||. .....    | ..|.|||||
NNGNYVAVLQDDGNFVIYDPDDNDSGNFIWQSFDHP
S_locus_glycop IRAKg_a-2.AA S_locus_glycop 235-277 37 7.3e-08 29.05 Pfam 55-99 (117) Show / Hide 
Range on Protein: 235-277
Range on HMM: 55-99/117
Sequence Identity: 37% (17 aa)

RLTLDDDGNLRLYT--LIEAVWSARWQAVSDQCQVYNYCGNYGIC
|.|.. .| |  .|       |   | | .||| .|. ||.||.|
RFTMSSEGYLQRFTWNPNSQDWNLFWYAPKDQCDYYRRCGPYGYC
B_lectin IRAKg_a-2.AA B_lectin 146-260 16 0.000129 1.46 SMART 1-126 (126) Show / Hide 
Range on Protein: 146-260
Range on HMM: 1-126/126
Sequence Identity: 16% (22 aa)

SSTLLPGQFLSRGRNLT-SRAGGYSLAMDQSGNLTLRWGS-----AQYWSS--DTDGNGNS-SIPTNAVVDVNGVLNLN------ATSTVRQFFPEDYGP
..||. ||.|. |  |. . .| ... |    |...  ..        |..   .|..... .    .. . .| | ..      ...|         ..
DNTLSSGQTLVSGNSLFEFYLGFFTFIMQ-WCNGIWYKNISNKQRTVVWVAQPNRDNPVHDGNNSCYLTMQSDGNLVIYDNRPVWSSNTT--------RN

GQSRRLTLDDDGNLRLYTLI-----EAVWSARWQA
    .. | ||||. .|        . .|.  .  
NGNYVAVLQDDGNFVIYDPDDNDSGNFIWQSFDHP
B_lectin IRAKg_a-2.AA B_lectin 235-256 39 0.546152 4.97 Pfam 27-54 (137) Show / Hide 
Range on Protein: 235-256
Range on HMM: 27-54/137
Sequence Identity: 39% (11 aa)

RLTLDD-DGNLRLYTLI---EA--VWSA
.||... |||| ||      .   |||.
TLTMQNRDGNLVLYDGGNGGSVRPVWST
Kinase IRAKg_a-2.AA TKL 491-773 19 2.2e-54 187.0 In-house 1-364 (364) Show / Hide 
Range on Protein: 491-773
Range on HMM: 1-364/364
Sequence Identity: 19% (78 aa)

IGEGGFGPVYKGSIA-LPVSK------TAIAVKKLEG---IFQGE-------------------------KEFRTEVATIGSTHHMNLMRLVGFCAEGAE
||.|||| ||||     .. |      . .||||.      .  .                         .... |.  . ...| |. ...|.| ..  
IGSGGFGEVYKGKWRGWGG-KCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPC

T------------RLLVYEFLPNGS-LDRFLFQPLAPGEDEDDSYQGARPSLDWPTRFKIALGTARALAYLHE----ECREP--IVHCDLKPENILLDDS
.              .|.|. |.|| |....                      |. |...||..||...|||      |. .  |.|.|||..|||.|. 
GCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------------------WHQRCRWALDIARGMNYLHSMNPKWCT-KPPIIHRDLKSKNILVDEN

FA--------------PKVSDFGLARLIDEG------------------NARNLTTVRGTRGYMAPEWLANM----------------PITAKSDVYSYG
.               .|..||||.| ...                   |. .. |..|| ..|||| | ..                . . |.||||.|
WTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFG

MVVLELVGGRRNFDTCRAVPRGMQRYPAYLYRELEAG--RLEGAVD------ERMYRADVDGVQLERVVKAAFWCIQDVASARPVMSKVVQML
.|  |.. ..| ..     |. .|. | .      ..  .|   ..      . .         .... | . .| .  ...|| ...... |
IVLWEILTRCRPYYDYPYMPMIFQD-P-FEEMFMMVCDKGLRPPIPPIWQNHH-K-M-CPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Pkinase IRAKg_a-2.AA Pkinase 485-698 26 2.7e-46 164.77 Pfam 1-209 (293) Show / Hide 
Range on Protein: 485-698
Range on HMM: 1-209/293
Sequence Identity: 26% (61 aa)

YNFQTRIGEGGFGPVYKGSIALPVSKTAIAVKKLEGIFQGEKEFRT-----EVATIGSTHHMNLMRLVGFCAEGAETRLLVYEFLPNG----SLDRFLFQ
| .  .||.|.|| |||.      .    |||...   . ... .|     |..   . .| |  || ... .      .| |....|    .| ...  
YHIGRKIGSGSFGCVYKCH--HKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYIST

PLAPGEDEDDSYQGARPSL--DWPTRFKIALGTARALAYLHEECREPIVHCDLKPENILLDDSFAP----KVSDFGLARLIDEGNARNLTTVRGTRGYMA
              .. ..  .. .  .... ..|.|.|.|..    |.|.||||||||.|.   .    |..|||||...|. | . .||. ||..|||
-------------WRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMA

PEWLA-NMPITAKSDVYSYGMVVLELVGGR
||..  . ... |.|..|.| .. |.. ||
PEVIRGGQYYGPKVDMWSCGCILYEMLCGR
Kinase IRAKg_a-2.AA Dicty4 485-690 33 2.7e-35 115.29 In-house 1-206 (277) Show / Hide 
Range on Protein: 485-690
Range on HMM: 1-206/277
Sequence Identity: 33% (73 aa)

YNFQTRIGEGGFGPVYKGSIALPVSKTAIAVKKL----EGIFQGE-KEFRTEVATIGSTHHMNLMRLVGFCA---EGAETRLLVYEFLPNGSLDRFLFQ-
.|.. |||.|.|| ||||.       .. |||||    .. .. . .||| ||.  ..  | |.  . | |       .. . | |..| |.| . |   
INIEQRIGKGSFGEVYKGTWRG----KEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDK

PLAPGEDEDDSYQGARPSLDWPTRFK---IALGTARALAYLHE-ECREPIVHCDLKPENILLDDSFAPKVSDFGLARLIDEGN--ARNLTTVRGTRGYMA
|         | |  . .||||.. .   .|. .|| ...||.  ..  |.| |||. |.| |...  ||.||||.... ..     |..|. || ..||
P---------SEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV--IIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMA

PEWLANMPITAKSDVYSYGMV
|| ... | . |.||||.|.|
PEVMMHQPYNEKADVYSFGIV
Kinase IRAKg_a-2.AA LRRK 485-702 23 2.5e-33 115.27 In-house 1-284 (351) Show / Hide 
Range on Protein: 485-702
Range on HMM: 1-284/351
Sequence Identity: 23% (73 aa)

YNFQTRIGEGGFG-PVYKGSIALP------------------------VSKTAIAVKKLEG--------------------------------------I
  ..  ||.|||| .||..    .                         . . .|.||..                                       .
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

FQGEKEFRTEVATIGSTHHMNLMRLVGFCAEGAETRLLVYEFLPNGSLDRFLF---Q-PL--APGEDEDDSYQGARPSLDWPTRFKIALGTARALAYLHE
|.   ||| ||. . . .| |.. |.||| .    . .| |..|.|.|..||.   | ..   .            ....| .. ||||  |....||| 
FR---EFRHEVWIMSHLNHPNIVSLKGFCIHP---LCMVMEYAPHGDLYHFLHNKKQDGFHFMK------------AHISWMLKLKIALQIAKGMEYLH-

ECREPIVHCDLKPENILLDDSFAP------------KVSDFGLAR--LIDEGNARNLTTVRGTRGYMAPEWLANM---PITAKSDVYSYGMVVLELVGGR
 .. ||.|.|||..||||  | ..            |..|||. |   ..   ...  .. |. |.|||| . ..     | |.|.||.||.  ||. ..
SHNPPIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAK--GCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQ

-RNFD
 . ||
HHPFD
Kinase IRAKg_a-2.AA TKL-Unique 487-695 29 1.3e-32 112.44 In-house 1-222 (290) Show / Hide 
Range on Protein: 487-695
Range on HMM: 1-222/290
Sequence Identity: 29% (68 aa)

FQTRIGEGGFGPVYKGSIALPVSKTAIAVKKL--EGIFQGEKEFRTEVATIGSTH-HMNLMRLVGFCAE---GAETRLLVYEFLPNGSLDRFLFQPLAPG
|   |||||.|.||||    . ...|| ....  .  .. ..||. || ..   | | |. ...|.|.     .  . .| |..| |||.  | | .   
FWNKIGEGGYGQVYKG--KWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNN

EDEDDSYQGARPSLDWPTRFKIALGTARALAYLHEECREPIVHCDLKPENILLDDS-----FAPKVSDFGLARLIDEGNARNLT--------TVRGTRGY
    ...      |..  | |.|.  |... ||| .    | |.|||. |.|.|       .  |..||||... .  |. ...        |. |.  .
NNNNNNCK-----LNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRW

MAPEWLAN--MPITAKSDVYSYGMVVLELV
|||| | .    .. ||||||.|.|. |..
MAPEVLRMNFCQYSEKSDVYSFGIVLWEIA
Kinase IRAKg_a-2.AA IRAK 592-699 39 7.8e-31 106.58 In-house 104-222 (317) Show / Hide 
Range on Protein: 592-699
Range on HMM: 104-222/317
Sequence Identity: 39% (47 aa)

PSLDWPTRFKIALGTARALAYLHEEC-REPIVHCDLKPENILLDDSFAPKVSDFGLARLI--DEGNARNLT------TVRGTRGYMAPEWLA--NMPITA
. | |..|..|..|||... .||.     || | | |. |||||. | || .||||.|     ... .         .||||  ||.|| .      .| 
KPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQLTK

KSDVYSYGMVVLELVGGRR
|.|||| | |.||.. |.|
KTDVYSFGIVLLEVLTGCR
Kinase IRAKg_a-2.AA TK 485-773 15 3.1e-30 97.94 In-house 1-486 (486) Show / Hide 
Range on Protein: 485-773
Range on HMM: 1-486/486
Sequence Identity: 15% (79 aa)

YNFQTRIGEGGFG---PVYKGSIALPV-------------------------SKTAIAVKKLEGIFQGEKEFR----------------TEVATIGS--T
  .   .||| ||    ||||    .                           ..|....|..   . | .|                  | .   .   
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

HHMNLMRLVGFCAEGA-----------ETRLLVYEFLPNGS----LDRFLFQPLAPGEDEDDSYQG----------------------------------
|| |. ||.| | .|.           |  ..| |. |.|.    |. .| .   .. .| |....                                  
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

---------------------------ARPSLDWPTRFKIALGTARALAYLHEE----CREPIVHCDLKPENILLDDSFA-----------PKVSDFG--
                            .  |. ...  ...  |....|||.         .|| ||   |.|....              |..|||  
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

------LARLIDEGNARNLTTVRGTRG-------------------------YMAPEWLA---------NMPITAKSDVYSYGMVVLELVGGRRNFDTCR
      ||| |...     .. .||..                         .|||| |.         .   | ||||.|.| .. |.      |  ..
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEI------FTYGQ

AVPRG-MQR-------YPAYLYRELEAG-------RLEGAVDERMYRADVDGVQL-------------ERVVKAAFWCIQDVASARPVMSKVVQML
. . | |         ... ... |..|       . . .| .|| ..  ..                | .      | .  .. || .| ....|
EPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGL-N-EVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase IRAKg_a-2.AA LISK 596-699 29 6.2e-28 87.69 In-house 100-237 (296) Show / Hide 
Range on Protein: 596-699
Range on HMM: 100-237/296
Sequence Identity: 29% (42 aa)

WPTRFKIALGTARALAYLHEECREPIVHCDLKPENILLDDS----FAPKVSDFGLARLIDEGN--------------------------------ARN--
|| | ||||. |....|||. .   |.| |||  |.|....    .  || |||.||..|. |                                 |.  
WPQRVKIALDIACGMSYLHSMN---IIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESDPCMDNDMPMKRKIPKKCMNQRKRR

LTTVRGTRGYMAPEWLANMPITAKSDVYSYGMVVLELVGGRR
.| . ||   |||| |  .  . ..||.|.|.|..|......
MTIC-GTPYWMAPEMLLGQSYDESCDVFSFGIVLCEIITRVK
Kinase IRAKg_a-2.AA DRK 486-695 30 2.5e-27 89.65 In-house 2-196 (258) Show / Hide 
Range on Protein: 486-695
Range on HMM: 2-196/258
Sequence Identity: 30% (67 aa)

NFQTRIGEGGFGPVYKGSIALPVSKTAIAVKKLEGIFQG-E---KEFRTEVATIGSTHHMNLMRLVGFCAEGAETRLLVYEFLPNGSLDRFLFQPLAPGE
  . ||| |..| |. |.       | .|||.|       |   .||. |.  .    | |     | | .  .  . . |..| ||| . |  .     
KIGNRIGRGNYGEVFRGTWR----GTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDI-CICMEYMPRGSLYNILHDESI---

DEDDSYQGARPSLDWPTRFKIALGTARALAYLHEECREPIV-HCDLKPENILLDDSFAPKVSDFGLAR----LIDEGNARNLTTVRGTRGYMAPEWLANM
           ..||| . ....  |. . |||  |..||. | |||  | | |...  ||.||||.       . . |.   |  || .  ||| |.| 
-----------EMDWPLMKQMMFDCAKGMIYLH--CCNPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQHKFAM---TMCGTPCWTAPEVLRNQ

PITAKSDVYSYGMVVLELV
. | | ||||.. |  |.|
RYTEKADVYSFAIVLWECV
Kinase IRAKg_a-2.AA CZAK 485-698 29 6.7e-27 94.81 In-house 1-219 (279) Show / Hide 
Range on Protein: 485-698
Range on HMM: 1-219/279
Sequence Identity: 29% (70 aa)

YNFQTRIGEGGFGPVYKGSIALPVSKTAIAVKKLEGI-FQGEKE------FRTEVATIGSTHHMNLMRLVGFCAEGA-ETRLLVYEFLPNGSLDRFLFQP
  |   ||.| || |||.        . .|.|..  . |    |      |  ||. .    | | .  .| | |.  . .  | |.   |||.|.|   
LKFGQTIGQGFFGEVYKAYWR----GKDVAIKIIHRNQFRNKDENKEENMFQKEVSIMSKLCHPNCVQFLGACSEDGPNHHCIVMEWMGGGSLRRLL---

LAPGEDEDDSYQGARPSLDWPTRFKIALGTARALAYLHEECRE-PIVHCDLKPENILLDDSFA-------------PKVSDFGLARLIDEGNARNLTTVR
     ..  .|    |.| |    ..|.  ||   |||   .. ||.| ||   |||||.|                |..|||| |.  |. .   |   
-----TDHYFYHKQNPHLQW----NMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDHSYTPKNPVVSSRQDIICKINDFGLSREMMEQ-PFEMTQTM

GTRGYMAPEWLANMPITAKSDVYSYGMVVLELVGGR
|   .||||       | |.||||.||.. ... ..
GCLCWMAPECFKGENYTEKVDVYSFGMILWCIITCD
Kinase IRAKg_a-2.AA Pkinase_Tyr 485-690 28 3.6e-25 85.87 Pfam 1-203 (270) Show / Hide 
Range on Protein: 485-690
Range on HMM: 1-203/270
Sequence Identity: 28% (62 aa)

YNFQTRIGEGGFGPVYKGSIA--LPVSKTAIAVKKLEGIFQGE----KEFRTEVATIGST-HHMNLMRLVGFCAEGAET--RLLVYEFLPNGSLDRFLFQ
  |   .||| || ||||         |.  |||.|      |    ..|  |...  .  || |. ||.| | .  |    ..| |. |.|.|. .| .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

PLAPGEDEDDSYQGARPSLDWPTRFKIALGTARALAYLHEECREPIVHCDLKPENILLDDSFAPKVSDFGLARLIDEGNARNLTTVRGTRG----YMAPE
.              ...|. ..  ....  |....||..     ..| ||   |.|.....  |..||||||.| .      ...||        ||||
HR-----------EDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYY-YRKRGGGKLPIKWMAPE

WLANMPITAKSDVYSYGMV
 ....  | ||||.|.| .
CINYGKFTTKSDVWSFGVL
Kinase IRAKg_a-2.AA Dicty4-Unclassified 601-697 41 6e-25 82.34 In-house 113-204 (263) Show / Hide 
Range on Protein: 601-697
Range on HMM: 113-204/263
Sequence Identity: 41% (40 aa)

KIALGTARALAYLHEECREPIVHCDLKPENILLDDSFAPKVSDFGLARLIDEGNARNLTTVRGTRGYMAPEWLANMPITAKSDVYSYGMVVLELVGG
|.|.  |. ...||   |. ..| |.|  |||.|  |  |. |||..| ||  .  |.||. ||    .|| |     . |||||||.|.  ||. |
KYAFDIAQGMQHLH--TRN-FIHRDIKSSNILMDKHFNIKIADFGISRVID--FNFNMTTIAGTPKWESPECLMHESYNQKSDVYSYAMMLYELATG
Kinase IRAKg_a-2.AA S_TKc 485-773 22 1.2e-20 75.83 SMART 1-231 (231) Show / Hide 
Range on Protein: 485-773
Range on HMM: 1-231/231
Sequence Identity: 22% (69 aa)

YNFQTRIGEGGFGPVYKGSIALPVSKTAIAVKKLEGIFQGEKEFRTEVATIGSTHHMNLMRLVGFCAEGAETRLLVYEFLPN--GSLDRFLFQPLAPGED
| .   ||.|.|| |||.      ..   |.|..       . .| |..   . || |. .| ... .  .   .| |....  |.| ... .   .| .
YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

EDDSYQGARPSLDWPTRFKIALGTARALAYLHEECREPIVHCDLKPENILLDDSFAPKVSDFGLARLIDEGNARNLTTVRGTRGYMAPEWLANMPITA-K
   .   ||         ...  ...||.|.|.     |.|.||||||||||.    |..||||||..        ||. ||. ||||| |   . .  |
FPFPE-HAR---------FYMYQICCALEYCHSHG---IIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCK

SDVYSYGMVVLELVGGRRNFDTCRAVPRGMQRYPAYLYRELEAGRLEGAVDERMYRADVDGVQLERVVKAAFWCIQDVASARPVMSKVVQ---------M
.|..| | .. |.. |.  |.            .. ... .                       . .      | |   . ||   .. |          
CDWWSCGCILYEMLCGYPPFP-----------QMQMMFKKIG---------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPW

L
.
F
Kinase IRAKg_a-2.AA TyrKc 485-773 21 7.9e-18 65.53 SMART 1-280 (280) Show / Hide 
Range on Protein: 485-773
Range on HMM: 1-280/280
Sequence Identity: 21% (71 aa)

YNFQTRIGEGGFGPVYKGSIALPVSKTAIAVKKLEGIFQGEKEFRTEVATIGST--HHMNLMRLVGFCAEGA------ETRLLVYEFLPNGSLDRFLFQP
  .   .||| || ||||        .  |||.|      ...|. |     .   || |. ||.| | ..       |  ..| |. |.|.|. .|  .
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

LAPGEDEDDSYQGARPSLDWPTRFKIALGTARALAYLHEECREPIVHCDLKPENILLDDSFAPKVSDFGLARLIDEG----NARNLTTVR---GTRG---
                 | ...  ....  |.  .|||.    ...| ||   |.|... .  |.|||||.| |...     .    ...   |...   
RPK--------------LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLP

--YMAPEWLANMPITAKSDVYSYGMVVLELV-------GG-----RRNFDTCRAVPRG-MQRYPAYLYRELEAGRLEGAVDERMYRADVDGVQ-LERVVK
   |||| .     | ||||.|.| .  |.         |       |..  . | .| . . |.. | ..                    |   . . .
IRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-PMS----------------F--VCCPDEMYQ

AAFWCIQDVASARPVMSKVVQML
   .| .  .. || .| ... .
IMKQCWHEDPEDRPTFSEIHECF
Kinase IRAKg_a-2.AA IRAK 485-569 34 7.2e-13 42.09 In-house 1-90 (317) Show / Hide 
Range on Protein: 485-569
Range on HMM: 1-90/317
Sequence Identity: 34% (33 aa)

YNFQTRIGEGGFGPVYKGSIALPVSKTA--IAVKKLE-----GIFQGEKEFRT---EVATIGSTHHMNLMRLVGFCAEGAETRLLVYEFLPNGSL
..   |||||||| ||.| .    . |.   |||||       . . ...|..   |. .  . .| |.  | |.|.|. .   |||...|||||
FHKDNRIGEGGFGCVYRGQW----KNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCH-CLVYPYMPNGSL
Kinase IRAKg_a-2.AA Dicty4-Unclassified 486-569 31 2e-06 17.84 In-house 2-89 (263) Show / Hide 
Range on Protein: 486-569
Range on HMM: 2-89/263
Sequence Identity: 31% (29 aa)

NFQTRIGEGGFGPVYKGSIALPVSKTAIAVKKL-EGIFQGE----KEFRTEVATIGSTHHMNLMRLVGFCAEG---AETRLLVYEFLPNGSL
     ||.| |  |.||          .||||. |. |.      ..|. ||.  ||  | ||... | |        |   | ||.. | |
QIDQFIGKGHFSKVHKGNWK----GKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNL
Kinase IRAKg_a-2.AA LISK 490-503 64 0.00074 8.19 In-house 1-14 (296) Show / Hide 
Range on Protein: 490-503
Range on HMM: 1-14/296
Sequence Identity: 64% (9 aa)

RIGEGGFGPVYKGS
 ||.|.|| ||||.
EIGKGFFGKVYKGT