IRAKg_h

Species: S.moellendorffii
Alias: IRAKg_h
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAKg

Sequence

Name Sequence Type Origin Length Description Download
IRAKg_h.AA Protein None 659 None Fasta, JSON
IRAKg_h.NA RNA None 1980 None Fasta, JSON
IRAKg_h.kin_dom Protein Kinase Domain None 113 None Fasta, JSON

Protein domain

Protein domains of IRAKg_h.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
B_lectin IRAKg_h.AA B_lectin 77-168 35 7.3e-20 69.83 Pfam 1-109 (137) Show / Hide
Range on Protein: 77-168
Range on HMM: 1-109/137
Sequence Identity: 35% (39 aa)

PNTVVWSAMSNDTGGFPI-GLI--KGDQLVFQT-DGRLVLTSNAAG--I--IWGT--STSTLG---VTKALLQENGNLQLLT-SN--GVPVWQS--FDRP
. ||||.|  .  .| |. .     . .|..|. || |||. ...|  .  .| |  .||. |    . | .|..||| |.. .|  . ..|||  || |
NQTVVWVANRDL-TGNPVTDSSNNGNYTLTMQNRDGNLVLYDGGNGGSVRPVWSTNNNTSGSGSANNCRAQMQDSGNLVLYDDNNDSNNVLWQSNTFDHP

TDTILPDQQL
|||.|| . |
TDTWLPGMKL

B_lectin IRAKg_h.AA B_lectin 36-158 26 7.9e-16 59.82 SMART 1-126 (126) Show / Hide
Range on Protein: 36-158
Range on HMM: 1-126/126
Sequence Identity: 26% (36 aa)

NVRGEDPQTWITSPNATFS--TGFSHLNPKSPLYSFSIWYTKM---PNTVVWSAMSNDTGGFPIGLIKG----DQLVFQTDGRLVLTSNAAGIIWGTSTS
.    . || . |.| .|.   ||  ...       .||| ..   . ||||.|    ..    .. ..      |..|.|| ||.      ..| ..|.
DNTLSSGQT-LVSGNSLFEFYLGFFTFIMQ---WCNGIWYKNISNKQRTVVWVAQP-NRD----NPVHDGNNSCYLTMQSDGNLVIYD--NRPVWSSNTT

-TLGVTKALLQENGNLQLLTSN----GVPVWQSFDRP
 . |.. | ||..||. .  ..    |  .||||| |
RNNGNYVAVLQDDGNFVIYDPDDNDSGNFIWQSFDHP

S_locus_glycop IRAKg_h.AA S_locus_glycop 263-325 31 3.9e-14 50.75 Pfam 55-117 (117) Show / Hide
Range on Protein: 263-325
Range on HMM: 55-117/117
Sequence Identity: 31% (20 aa)

RLTLDDDGNLRIYTLDEIKKRWIITWQAVLLECDIFGKCGRFGICAYRPTATCICPPGFHPTN
|.|.. .| | ..|  .  ..|.  | |   .||. . ||..|.|    . .| | .||.| |
RFTMSSEGYLQRFTWNPNSQDWNLFWYAPKDQCDYYRRCGPYGYCDMNTSPMCNCIKGFVPKN

B_lectin IRAKg_h.AA B_lectin 263-275 50 9.933461 0.64 Pfam 27-40 (137) Show / Hide
Range on Protein: 263-275
Range on HMM: 27-40/137
Sequence Identity: 50% (7 aa)

RLTLDD-DGNLRIY
.||... |||| .|
TLTMQNRDGNLVLY

Kinase IRAKg_h.AA TKL 502-557 34 7.8e-19 64.46 In-house 131-205 (364) Show / Hide
Range on Protein: 502-557
Range on HMM: 131-205/364
Sequence Identity: 34% (26 aa)

WASRFNIALGIARGITYLHDEC-----QECILHCDIKPQNILLDESFC--------------PKVADFGLAKLMK
|  |...||.||||. ||| .         |.|.|.|..|||.|| .               .|..||||.. |.
WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMS

Kinase IRAKg_h.AA IRAK 502-553 49 1.5e-17 58.93 In-house 108-160 (317) Show / Hide
Range on Protein: 502-553
Range on HMM: 108-160/317
Sequence Identity: 49% (26 aa)

WASRFNIALGIARGITYLHDEC-QECILHCDIKPQNILLDESFCPKVADFGLA
|  |. |..|.|.|| .||.      | | |||. |||||. | || .||||.
WHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLH

Kinase IRAKg_h.AA Pkinase_Tyr 442-504 39 1.8e-16 56.42 Pfam 2-74 (270) Show / Hide
Range on Protein: 442-504
Range on HMM: 2-74/270
Sequence Identity: 39% (29 aa)

NFCDKLGSGGFGTVYKGRLP-----NGTLVAVKEL-EIAMQAD---KQFQAEVKTLGKI-HHINLVRLLGWAS
 |  |||.| ||.||||..      ... |||| | | ||. .   . | .|.|.. .. || |.|||.|  .
TFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCT

Kinase IRAKg_h.AA Dicty4 508-563 41 3.7e-15 47.17 In-house 117-171 (277) Show / Hide
Range on Protein: 508-563
Range on HMM: 117-171/277
Sequence Identity: 41% (23 aa)

IALGIARGITYLHDECQECILHCDIKPQNILLDESFCPKVADFGLAKLMKRERALK
.|. .|||...|| .|   |.| |.|. |.| |...  ||.||||...||..  .|
MAFDAARGMNWLH-CCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHK

Kinase IRAKg_h.AA LISK 500-560 41 3.6e-14 42.22 In-house 98-159 (296) Show / Hide
Range on Protein: 500-560
Range on HMM: 98-159/296
Sequence Identity: 41% (27 aa)

LGWASRFNIALGIARGITYLHDECQECILHCDIKPQNILLDES----FCPKVADFGLAKLMKRER
| |  | .|||.||.| .|||.    .|.| | | .|.|..|.    .  ||.|||.|..|  |.
LPWPQRVKIALDIACGMSYLHS---MNIIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCEN

Kinase IRAKg_h.AA TyrKc 441-628 17 3.1e-13 -8.72 SMART 1-280 (280) Show / Hide
Range on Protein: 441-628
Range on HMM: 1-280/280
Sequence Identity: 17% (49 aa)

DNFCDKLGSGGFGTVYKGRLPNGTLVAVKELE-IAMQADKQFQAEVKTLGKI--HHINLVRLLGWASRF-------------------------------
  . .|||.| ||.||||..   . |||| |   |    . |  | . . |.  || |.|||.| ..                                 
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

--------NIALGIARGITYLHDECQECILHCDIKPQNILLDESFCPKVADFGLAKLMKRE-------RALKN----NRW-----------CLSDWAYN-
        .... ||.|  |||.    .. | |.   |.|..| .. |..||||..  . .          .     ..            |. .  .. 
KLCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

-------------------MYQAG---------DLESIVDKKLVQEEVNVV-------QFKRLLKVALWCIQHDANARPSMGKVVQMM
                   .   |         ..   |..    .    .         . . .. ..| ..|.. ||..  ... .
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF

Kinase IRAKg_h.AA TKL 447-501 22 3.7e-13 43.74 In-house 1-92 (364) Show / Hide
Range on Protein: 447-501
Range on HMM: 1-92/364
Sequence Identity: 22% (21 aa)

LGSGGFGTVYKGRLPN---------GTLVAVKELEI----------------------------AMQADKQFQAEVKTLGKIHHINLVRLLG
.||||||.||||.. .         |. |||| . .                            |... ...  |.. . ...| |.|...|
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMG

Kinase IRAKg_h.AA TKL-Unique 505-566 34 1.1e-12 41.17 In-house 112-177 (290) Show / Hide
Range on Protein: 505-566
Range on HMM: 112-177/290
Sequence Identity: 34% (23 aa)

RFNIALGIARGITYLHDECQECILHCDIKPQNILLDES-----FCPKVADFGLAKLMKRERALKNNR
| ..|. ||.|  ||| .    |.|.|.|..|.|.|.      .  |..||||.|. ... . .||.
RVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNE

Kinase IRAKg_h.AA IRAK 439-501 31 1.7e-12 40.75 In-house 1-70 (317) Show / Hide
Range on Protein: 439-501
Range on HMM: 1-70/317
Sequence Identity: 31% (23 aa)

FTDNFCDKLGSGGFGTVYKGRLPNGT-LVAVK------ELEIAMQADKQFQA---EVKTLGKIHHINLVRLLG
|  ..  ..|.||||.||.|.. | |  .|||      .... .  ...||.   |.|.. ...| |.| |.|
FHKDN--RIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNE-HWQRFQQSYNELKVCCRCRHPNIVPLYG

Kinase IRAKg_h.AA Pkinase 507-566 35 1.9e-12 45.11 Pfam 112-167 (293) Show / Hide
Range on Protein: 507-566
Range on HMM: 112-167/293
Sequence Identity: 35% (23 aa)

NIALGIARGITYLHDECQECILHCDIKPQNILLDESFCP----KVADFGLAKLMKRERALKNNR
.... |.||. |.|..    |.|.|.||.|||.|.   .    |..||||||...    . ||.
FYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD----Y-NNS

Kinase IRAKg_h.AA MLK 503-554 37 2.8e-12 39.0 In-house 124-181 (291) Show / Hide
Range on Protein: 503-554
Range on HMM: 124-181/291
Sequence Identity: 37% (22 aa)

ASRFNIALGIARGITYLHDECQECILHCDIKPQNILLDE------SFCPKVADFGLAK
.. .|.|| .|||. ||| . .  | | |.|..|||.||          |..|||...
DHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSR

Kinase IRAKg_h.AA ULK 445-502 25 1e-11 37.92 In-house 5-83 (324) Show / Hide
Range on Protein: 445-502
Range on HMM: 5-83/324
Sequence Identity: 25% (20 aa)

DKLGSGGFG-TVYKGR-LPN---GTLVAVKELE---IAMQADK--------QFQAEVKTLGKIH---HIN--LVRLLGW
..||.| || .|||||   .   . .||.|  .   . ..  .        ... |.... |..   | |   |.|. |
HCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDW

Kinase IRAKg_h.AA ULK 527-554 42 1.3e-11 36.86 In-house 151-190 (329) Show / Hide
Range on Protein: 527-554
Range on HMM: 151-190/329
Sequence Identity: 42% (17 aa)

ILHCDIKPQNILLDESF------------CPKVADFGLAK
| |.||||||||... .            . |.||||.||
IIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAK

Kinase IRAKg_h.AA ULK 527-554 42 2.9e-11 36.26 In-house 147-186 (324) Show / Hide
Range on Protein: 527-554
Range on HMM: 147-186/324
Sequence Identity: 42% (17 aa)

ILHCDIKPQNILLDESF------------CPKVADFGLAK
| |.||||||||. . .            . |.||||.||
IIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAK

Kinase IRAKg_h.AA S_TKc 441-632 20 3.8e-11 -13.5 SMART 1-231 (231) Show / Hide
Range on Protein: 441-632
Range on HMM: 1-231/231
Sequence Identity: 20% (52 aa)

DNFCDKLGSGGFGTVYKGRLPN-GTLVAVKELEIAMQADKQFQAEVKTLGKIHHINLVRLLGWAS--RFNIALGIARG-----ITYLHDEC---------
  . .|.|.|.||.|||.|  . | .||.|..       .... |.. | | || |.|.|...    .. . .  . |      .|...           
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP

------------------QECILHCDIKPQNILLDESFCPKVADFGLAKLMKRERALKNNRW----------C-LSDW------AYNMYQ-----AGDLE
                  .  |.|.|.||.||||||  . |..|||||...   . .   .|          .  .||       | |.        ...
EHARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---TTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEMLCGYPPFP-QMQ

SIVDKKLVQEEVNVVQFKRLLKVALWCIQHDANARPSMGKVVQ-----MMEDIV
 . .| .          . ..     | | | . ||.  .. |     ..   .
MMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase IRAKg_h.AA RAF 506-559 35 5.2e-11 31.62 In-house 106-156 (282) Show / Hide
Range on Protein: 506-559
Range on HMM: 106-156/282
Sequence Identity: 35% (19 aa)

FNIALGIARGITYLHDECQECILHCDIKPQNILLDESFCPKVADFGLAKLMKRE
..|.. .. |  |||   .  |.| |.| .||.|.|    |. ||||... .|.
IDISRQVCQGMDYLH---AKNIIHRDLKSNNIFLHEDMTVKIGDFGLMTVKTRW

Kinase IRAKg_h.AA CAMK 446-502 14 5.6e-11 30.87 In-house 1-106 (425) Show / Hide
Range on Protein: 446-502
Range on HMM: 1-106/425
Sequence Identity: 14% (15 aa)

KLGSGGFGTVYKGRLP-NG------------TLVAVKELEIA-----------------------------MQADKQFQAEVKTLGK-------IHHINL
.||.|.||.|....   ..            . ||.| ..                                .  |... |.. . |       ..| |.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VRLLGW
..|. .
IKLYEV

Kinase IRAKg_h.AA ULK 445-502 26 1.2e-10 33.46 In-house 5-86 (329) Show / Hide
Range on Protein: 445-502
Range on HMM: 5-86/329
Sequence Identity: 26% (22 aa)

DKLGSGGFGTVYKGR-LPN----GTLVAVKELEIA-MQADK----------QFQAEVKTLGKIH----HIN----LVRLLGW
..||.| ||.|||||   .    . .||.| ...  |. ..          ... |.|.. |..    |.|     |.|. |
HCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDW

Kinase IRAKg_h.AA CAMK 527-558 30 1.4e-10 29.58 In-house 200-248 (425) Show / Hide
Range on Protein: 527-558
Range on HMM: 200-248/425
Sequence Identity: 30% (15 aa)

ILHCDIKPQNILLDES-----------------FCPKVADFGLAKLMKR
| |.|.|| |||||..                 .  |..|||.|. ...
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDP

Kinase IRAKg_h.AA TKL-Unique 443-502 36 1.8e-10 33.29 In-house 1-64 (290) Show / Hide
Range on Protein: 443-502
Range on HMM: 1-64/290
Sequence Identity: 36% (24 aa)

FCDKLGSGGFGTVYKGRLPNGTLVAVKELEI-AMQADK--Q-FQAEVKTLGKIH-HINLVRLLGW
|  |.|.||.|.||||   .|. ||.| ... . .  .  | |  ||... |.| |.|.|.. |.
FWNKIGEGGYGQVYKGKW-RGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGY

Kinase IRAKg_h.AA LISK 446-498 28 1.9e-10 29.96 In-house 1-60 (296) Show / Hide
Range on Protein: 446-498
Range on HMM: 1-60/296
Sequence Identity: 28% (17 aa)

KLGSGGFGTVYKGRLP-NGTLVAVKELEI------AMQADKQFQAEVKTLGKIHHINLVR
..|.|.|| ||||..   |. .|.|....         . | .. ||... .. | | |.
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQ

Kinase IRAKg_h.AA RAF 442-505 35 1.3e-09 27.01 In-house 2-69 (282) Show / Hide
Range on Protein: 442-505
Range on HMM: 2-69/282
Sequence Identity: 35% (25 aa)

NFCDKLGSGGFGTVYKGRLPNGTLVAVKELEIAMQADKQFQA------EVKTLGKIHHINLVRLLGWASR
    . ||| |||||.|.   |. |||| | ..    .|.||      ||  . |  |.| .  .|. |.
MVMTRIGSGSFGTVYRGHW-HGD-VAVKMLNVNDPTPEQMQADVFFKNEVAVYKKTRHCNILLFMGYMSK

Kinase IRAKg_h.AA MLK 442-501 28 8.7e-09 26.75 In-house 2-76 (291) Show / Hide
Range on Protein: 442-501
Range on HMM: 2-76/291
Sequence Identity: 28% (21 aa)

NFCDKLGSGGFGTVYKGRLPNGT----LVAVKELEI---AMQA----DKQFQAEVKTLGKIHHIN----LVRLLG
.|  ..|||.|| |.|||  | .     ||||. ..   ...     ...|. |.. | .. | |     ....|
QFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYG

Kinase IRAKg_h.AA Dicty4 442-501 36 3e-08 23.81 In-house 2-65 (277) Show / Hide
Range on Protein: 442-501
Range on HMM: 2-65/277
Sequence Identity: 36% (24 aa)

NFCDKLGSGGFGTVYKGRLPNGTLVAVKELEIAMQAD-----KQFQAEVKTLGKIHHINLVRLLG
|. ...|.|.||.||||.   |. |||| |    | .     . | .||. ..|| | |.. ..|
NIEQRIGKGSFGEVYKGTW-RGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMG

Kinase IRAKg_h.AA Pkinase 446-502 33 3.6e-08 29.95 Pfam 6-68 (293) Show / Hide
Range on Protein: 446-502
Range on HMM: 6-68/293
Sequence Identity: 33% (21 aa)

KLGSGGFGTVYKGRLPNG-TLVAVKELEIAMQADKQFQA-----EVKTLGKIHHINLVRLLGW
|.|||.||.|||..  .   .||||...   . ... |.     |.. . ...| | |||..|
KIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDW

Kinase IRAKg_h.AA TKL 601-628 25 0.000138 12.45 In-house 337-364 (364) Show / Hide
Range on Protein: 601-628
Range on HMM: 337-364/364
Sequence Identity: 25% (7 aa)

KRLLKVALWCIQHDANARPSMGKVVQMM
... | . .| .||...|||. .... .
PSMKKLMQDCWDHDPEKRPSFQEILKRL

Kinase IRAKg_h.AA Pkinase_Tyr 507-556 32 0.003853 11.26 Pfam 115-161 (270) Show / Hide
Range on Protein: 507-556
Range on HMM: 115-161/270
Sequence Identity: 32% (16 aa)

NIALGIARGITYLHDECQECILHCDIKPQNILLDESFCPKVADFGLAKLM
.... ||.|  ||..     . | |.   |.|..|... |..|||||...
QMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDI

Kinase IRAKg_h.AA RAF 601-630 13 0.013359 3.91 In-house 253-282 (282) Show / Hide
Range on Protein: 601-630
Range on HMM: 253-282/282
Sequence Identity: 13% (4 aa)

KRLLKVALWCIQHDANARPSMGKVVQMMED
| . . .. |.. . . ||. ........ 
KAMHRLMEDCWKFQREERPLFQQILKRITV

Kinase IRAKg_h.AA IRAK 601-628 35 0.02597 4.2 In-house 290-317 (317) Show / Hide
Range on Protein: 601-628
Range on HMM: 290-317/317
Sequence Identity: 35% (10 aa)

KRLLKVALWCIQHDANARPSMGKVVQMM
| .. .|. |  | || |..| .|.| .
KEMCQCACCCGHHRANRRCDMAWVMQQL

Kinase IRAKg_h.AA LISK 603-628 30 0.026662 3.05 In-house 271-296 (296) Show / Hide
Range on Protein: 603-628
Range on HMM: 271-296/296
Sequence Identity: 30% (8 aa)

LLKVALWCIQHDANARPSMGKVVQMM
.|.....|.  | . |||  ..||  
FLDLCFDCCKYDPKNRPSFKEIVQWL

Kinase IRAKg_h.AA Dicty4 609-630 37 0.04906 2.78 In-house 254-277 (277) Show / Hide
Range on Protein: 609-630
Range on HMM: 254-277/277
Sequence Identity: 37% (9 aa)

WCIQHDANARPSMGKVVQM--MED
||  || . |||.  ..|   .| 
WCWDHDPQHRPSFEEIIQRRILEH

Kinase IRAKg_h.AA Pkinase_Tyr 608-628 19 0.969059 3.13 Pfam 250-270 (270) Show / Hide
Range on Protein: 608-628
Range on HMM: 250-270/270
Sequence Identity: 19% (4 aa)

LWCIQHDANARPSMGKVVQMM
. | ..|.. ||..  .....
KQCWHYDPEDRPTFSEIHEQL