Gene IRAKh_a-2 (S.moellendorffii)

IRAKh_a-2

Species: S.moellendorffii
Alias: IRAKh_a-2
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAKh

Sequence

Name Sequence Type Origin Length Description Download
IRAKh_a-2.AA Protein None 337 None Fasta, JSON
IRAKh_a-2.NA RNA None 1014 None Fasta, JSON
IRAKh_a-2.kin_dom Protein Kinase Domain None 206 None Fasta, JSON

Protein domain

Protein domains of IRAKh_a-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IRAKh_a-2.AA IRAK 45-322 31 1.3e-71 244.23 In-house 1-317 (317) Show / Hide 
Range on Protein: 45-322
Range on HMM: 1-317/317
Sequence Identity: 31% (102 aa)

FSYDNFIGEGGFGRVYRGVLRTGK-PVAIK-QMDPTLSRGTQGEREFRV---EVDLLSRLSHPSLVRLIGYCADRKQRMLVYEFMTQGSLQEHLHGIVRI
|. || ||||||| ||||...    ..|.|  .    .  .. ...|.    |. ...|. || .| | |||..| .  |||..|. |||.  |..    
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

KM----NWQVRIRIALGSARALEYLH-AGPATGNPIIHRDFKSSNILLDETFQAKVSDFGLAKLV-PHGNKTYVST------RVLGTFGYFDPHYTA--T
 .     |. |. |..|.|.....|| ..|.|  ||||.| ||.|||||. |..| .||||.    | ..| . .       .| ||  |  |..    .
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCT--PIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQ

GRLTLKSDVYAFGVVLLELLTGRRPVDSAHSF--TKQNLVFQVRDSLRD-----S--------------RKL---KKIIDPEISLESCSWESIKRFAMLA
|.|| |.||| ||.||||.|||.|.|.. ..   .. .|.  . .. .      |              |..   .| ||. .  ..|  .. | ....|
GQLTKKTDVYSFGIVLLEVLTGCRAVYDDRPEHYYLKDLCEEIMEEWGHLDSCQSTLWVGVATDAWAAPRRMQIYEKFIDHRM--PPCPPNMEKEMCQCA

YCCVRDDDTRRPTMGECVAEL
 ||.     ||..| . ...|
CCCGHHRANRRCDMAWVMQQL
Kinase IRAKh_a-2.AA TKL 51-322 23 1.8e-63 217.2 In-house 1-364 (364) Show / Hide 
Range on Protein: 51-322
Range on HMM: 1-364/364
Sequence Identity: 23% (90 aa)

IGEGGFGRVYRGVLRT---------GKPVAIKQMDPTL-----------------------SRGTQGEREFRVEVD-LLSRLSHPSLVRLIGYCADRKQ-
||.|||| ||.|..|          ||.||.|..  .                        .. .. .|.|..|.  ..|||.|| .|...||| . .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------RMLVYEFMTQGSLQEHLHGIVRIKMNWQVRIRIALGSARALEYLHA-----GPATGNPIIHRDFKSSNILLDETFQ------------
             ..|.|..  ||| ..||        |..|.|.||. ||...|||.     .     |||||| ||.|||.|| ..            
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCT--KPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD

--AKVSDFGLAK-LVPHGNKTYVSTR----------------VLGTFGYFDPHYTA----------------TGRLTLKSDVYAFGVVLLELLTGRRPVD
  .|..||||.. . ..||..  .|                 . ||...  |                     .  . |.|||.||.|| |.||..|   
WCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR---

SAHSFTKQNLVFQ-VRDSLRD---------SRKLKKIIDPEISLE-------SCSWESIKRFAMLAYCCVRDDDTRRPTMGECVAEL
          ...    . ..         .   .|   |.|  .       ..     .... |. .|   | . ||.. |.. .|
----------PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAKh_a-2.AA TKL-Unique 49-250 34 5e-51 175.83 In-house 3-233 (290) Show / Hide 
Range on Protein: 49-250
Range on HMM: 3-233/290
Sequence Identity: 34% (81 aa)

NFIGEGGFGRVYRGVLRTGKPVAIKQMDPTLSRGT-QGEREFRVEVDLLSRLS-HPSLVRLIGYCA----DRKQRMLVYEFMTQGSLQEHLHG-------
| |||||.|.||.|. | |.||||||  | ..    . ..||. || ....|  || .|...|||.    . ... .| |..  ||| ..||        
NKIGEGGYGQVYKGKWR-GYPVAIKQFHP-NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

-IVRIKMNWQVRIRIALGSARALEYLHAGPATGNPIIHRDFKSSNILLDET-----FQAKVSDFGLAKLVPHGNKTYVS-------TRVLGTFGYFDPHY
 .  .|.|.|.|...|.  |....|||    .. |||||| ||||.|.|.      ...|..||||.|.    ||. ..       . ..|.| .  |  
NNNNCKLNMQQRVKMAIDIAQGMYYLH---HCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEV

TAT--GRLTLKSDVYAFGVVLLELLTGRR------P
.       . |||||.||.|| |..|. .      |
LRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKP
Kinase IRAKh_a-2.AA S_TKc 45-327 22 7.2e-37 129.72 SMART 1-231 (231) Show / Hide 
Range on Protein: 45-327
Range on HMM: 1-231/231
Sequence Identity: 22% (67 aa)

FSYDNFIGEGGFGRVYRGVLRT-GKPVAIKQMDPTLSRGTQGEREFRVEVDLLSRLSHPSLVRLIGYCADRKQRMLVYEFMTQ--GSLQEHLHGIVRIK-
.   . ||.|.||.||... .  |. ||||...          . .| |...|..  || .|.|.... | .   .| |.. .  |.| ....   | . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---MNWQVRIRIALGSARALEYLHAGPATGNPIIHRDFKSSNILLDETFQAKVSDFGLAKLVPHGNKTYVSTR------VLGTFGYFDPHYTATGRLTL-
   ..  .  ...   ..||||.|      . ||||| | .||||||  . |..|||||...    .|.. |.      ||                .  
RFPFPE-HARFYMYQICCALEYCHS-----HGIIHRDLKPENILLDE--HIKICDFGLARQL----TTFCGTPWYMAPEVL--------------GYGKC

KSDVYAFGVVLLELLTGRRPVDSAHSFTKQNLVFQVRDSLRDSRKLKKIIDPEISLESCSWESIKRFAMLAYCCVRDDDTRRPTMGECVA----ELEQLY
|.|....|..| |.|.|. | .     . | .  ...                           . .  .   | . | ..|||  |. .         .
KCDWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG--------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPW

L
.
F
Kinase IRAKh_a-2.AA LRRK 45-209 25 1.8e-36 126.5 In-house 1-242 (351) Show / Hide 
Range on Protein: 45-209
Range on HMM: 1-242/351
Sequence Identity: 25% (64 aa)

FSYDNFIGEGGFG-RVYRGVLRT---------------------------GKPVAIKQMDPT--LSRGTQGE----------------------------
. . . ||.|||| .|||. .|                            ...||||... .  ..  .  .                            
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTID-NDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCR

--REFRVEVDLLSRLSHPSLVRLIGYCADRKQRMLVYEFMTQGSLQEHLH---GIVR----IKMNWQVRIRIALGSARALEYLHAGPATGN-PIIHRDFK
  |||| || ..|.| ||..| |.|.|   . ...| |....|.|...||      .    ....|.....|||  |...||||      | |||||| |
AFREFRHEVWIMSHLNHPNIVSLKGFC--IHPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHS----HNPPIIHRDLK

SSNILL---D---------ETFQAKVSDFGLAK---LVPHG-NKTYVST
| ||||   .         ..  ||..|||.      ...|  |..| .
SPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGN
Kinase IRAKh_a-2.AA Dicty4-Unclassified 45-250 32 5.6e-35 117.22 In-house 1-207 (263) Show / Hide 
Range on Protein: 45-250
Range on HMM: 1-207/263
Sequence Identity: 32% (71 aa)

FSYDNFIGEGGFGRVYRGVLRTGKPVAIKQMDPTLSRGTQGER-----EFRVEVDLLSRLSHPSLVRLIGYCADR----KQRMLVYEFMTQGSLQEHLH-
   | |||.| | .|..|. . || ||.|     .  .    |     .|. ||..|  ..|| ||.. |||          . | ||| .| | |  | 
IQIDQFIGKGHFSKVHKGNWK-GKDVAVKK----FNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHS

----GIVRIKMNWQVRIRIALGSARALEYLHAGPATGNPIIHRDFKSSNILLDETFQAKVSDFGLAKLVPHGNKTYVSTRVLGTFGYFDPHYTATGRLTL
        ||..  . |..|.  |. . .||        .|||| ||||||.|  | .|. |||..  .     ..  | . ||     |        . 
KPSEQQQPIKLDDTLIIKYAFDIAQGMQHLHT-----RNFIHRDIKSSNILMDKHFNIKIADFGISRVI---DFNFNMTTIAGTPKWESPECLMHESYNQ

KSDVYAFGVVLLELLTGRRP
||||| ....| ||.||  |
KSDVYSYAMMLYELATGDEP
Kinase IRAKh_a-2.AA TyrKc 45-322 22 5.8e-35 123.39 SMART 1-280 (280) Show / Hide 
Range on Protein: 45-322
Range on HMM: 1-280/280
Sequence Identity: 22% (71 aa)

FSYDNFIGEGGFGRVYRGVLRTGKPVAIKQMDPTLSRGTQGEREFRVEVDLLSRL--SHPSLVRLIGYCADR-------KQRMLVYEFMTQGSLQEHLHG
 . .  .||| ||.||.|...   .||.| . .        ...|. |  ....|  .|| .|||.|.| .        .. |.| |.|  |.|...|. 
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

IVRIKMNWQVRIRIALGSARALEYLHAGPATGNPIIHRDFKSSNILLDETFQAKVSDFGLAKLVPHG------NKTYV-----STR-----------VLG
  .   ...  . ...  |.  ||||       ..||||    |.|..| ...|.|||||.. . ..       ..|.     ...           .. 
HRPK-LCMKDLLSFCWQIACGMEYLHSK-----NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-

TFGYFDPHYTATGRLTLKSDVYAFGVVLLELLT-GRRPVDS---AHSFTKQNLVFQVRDSLRDSRKLKKIIDPEISLESCSWESIKRFAMLAYCCVRDDD
           .|. | ||||..|||.. |..| |  |          . | .. .|..  |  .       | .|    . .  .   ..  .| . | 
----------NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDY--P-MS----FVCCPDEMYQIMKQCWHEDP

TRRPTMGECVAEL
  |||. |.. ..
EDRPTFSEIHECF
Kinase IRAKh_a-2.AA LISK 50-199 34 9.7e-35 110.15 In-house 1-155 (296) Show / Hide 
Range on Protein: 50-199
Range on HMM: 1-155/296
Sequence Identity: 34% (55 aa)

FIGEGGFGRVYRGVLR-TGKPVAIKQMD--PTLSRGTQGEREFRVEVDLLSRLSHPSLVRLIGYCAD-RKQRMLVYEFMTQGSLQEHLH-GIV-RIKMNW
 ||.|.|| ||.| .| ||...|||.    |  .     .. .  || .. .|.||  |. .| |    .| ..| |..  | |.. |.   .  |   |
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW

QVRIRIALGSARALEYLHAGPATGNPIIHRDFKSSNILLDET----FQAKVSDFGLAKLV
..|..|||. |....|||.     . ||||| || |.|..|     ...|| |||.|...
PQRVKIALDIACGMSYLHS-----MNIIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMM
Kinase IRAKh_a-2.AA Pkinase 45-210 27 1.2e-33 120.0 Pfam 1-175 (293) Show / Hide 
Range on Protein: 45-210
Range on HMM: 1-175/293
Sequence Identity: 27% (49 aa)

FSYDNFIGEGGFGRVYRGVLRTG-KPVAIKQMDPTLSRGTQGEREFR-VEVDLLSRLSHPSLVRLIGYCADRKQRMLVYEFMTQG----SLQEHLHGIVR
.     ||.|.||.||... .   | ||.|...    .  . .. .|  |. .. ||.||  |||.... |..   .| |..  |    .| .....  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

IKM--NWQVRIRIALGSARALEYLHAGPATGNPIIHRDFKSSNILLDETFQA----KVSDFGLAK---LVPHGNKTYVSTR
 ..   ... .....  .|.|||.|.       ||||| |..|||.|.. .     |..||||||   . . ...|.. |.
GCFYFSEWECKFYMYQILRGLEYCHSM-----GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNSMTTFCGTP
Kinase IRAKh_a-2.AA Dicty4 45-197 33 1.4e-33 109.52 In-house 1-162 (277) Show / Hide 
Range on Protein: 45-197
Range on HMM: 1-162/277
Sequence Identity: 33% (56 aa)

FSYDNFIGEGGFGRVYRGVLRTGKPVAIKQM--DPT-LSRGTQGEREFRVEVDLLSRLSHPSLVRLIGYCA----DRKQRMLVYEFMTQGSLQEHLHG--
   ...||.|.|| ||.|  | || ||.| .  . . ..  .    ||| ||.... ..|| .. . |.|          . | |.| .|.| . ||   
INIEQRIGKGSFGEVYKGTWR-GKEVAVKKLNNHNQNFDENML--NEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKP

---IVRIKMNWQVRIR---IALGSARALEYLHA-GPATGNPIIHRDFKSSNILLDETFQAKVSDFGLAK
     .||. |  ..|   .|.  || . .||.  |     ||||| ||.|.| |. ...||.||||..
SEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV----IIHRDLKSHNLLVDKNWRVKVCDFGLSQ
Kinase IRAKh_a-2.AA MLK 45-197 29 3.5e-33 112.49 In-house 1-181 (291) Show / Hide 
Range on Protein: 45-197
Range on HMM: 1-181/291
Sequence Identity: 29% (54 aa)

FSYDNFIGEGGFGRVYRGVLRTGKP-----VAIKQMDPTLSRGTQGE----REFRVEVDLLSRLSHPS----LVRLIGYCADR-KQRMLVYEFMTQGSLQ
.    .||.|.|| |..|. | .|      ||.|. . .     . .    ..|. |. .|..||||      ... | |..  ..  .| |..  ||| 
IQFHEWIGSGSFGKVWKGRWR-NKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLY

EHLHGIVR------------IKMNWQVRIRIALGSARALEYLHA-GPATGNPIIHRDFKSSNILLDE------TFQAKVSDFGLAK
. |||.              . .  .. ...||  ||...|||.  |    |||||| ||.|||.||        ..|..|||...
NVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPK---PIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSR
Kinase IRAKh_a-2.AA Pkinase_Tyr 45-199 28 3.6e-33 112.95 Pfam 1-161 (270) Show / Hide 
Range on Protein: 45-199
Range on HMM: 1-161/270
Sequence Identity: 28% (48 aa)

FSYDNFIGEGGFGRVYRGVLR-----TGKPVAIKQMDPTLSRGTQGE----REFRVEVDLLSRL-SHPSLVRLIGYCA-DRKQ--RMLVYEFMTQGSLQE
 . .  .||| ||.||.|...     |. |||.| . .    |.  |    ..|  |. ... | .|| .|||.| |  ....   ..| |.|  |.| .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE----GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLD

HLHGI--VRIKMNWQVRIRIALGSARALEYLHAGPATGNPIIHRDFKSSNILLDETFQAKVSDFGLAKLV
.|.     . . . .  . ...  |...|||.. .     .||||    |.|..|....|..|||||...
YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN-----CIHRDLAARNCLVTENNVVKICDFGLARDI
Kinase IRAKh_a-2.AA DRK 48-246 36 1e-32 108.18 In-house 4-197 (258) Show / Hide 
Range on Protein: 48-246
Range on HMM: 4-197/258
Sequence Identity: 36% (73 aa)

DNFIGEGGFGRVYRGVLRTGKPVAIKQMDPTLSRG-TQGEREFRVEVDLLSRLSHPSLVRLIGYCADRKQRMLVYEFMTQGSLQEHLHGIVRIKMNWQVR
 | || |..| |.||  | |  ||.| | . .         ||. |..|...| ||  .  .| |        . |.|  |||   ||    |.| |  .
GNRIGRGNYGEVFRGTWR-GTQVAVK-MLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHD-ESIEMDWPLM

IRIALGSARALEYLHAGPATGNPII-HRDFKSSNILLDETFQAKVSDFGLAK-LVPHGNKTYVSTRVLGTFGYFDPHYTATGRLTLKSDVYAFGVVLLEL
.....  |. . |||      |||| ||| || | | || .| ||.||||.     |  ..   | . || .   |   .  | | | ||| |..|| |.
KQMMFDCAKGMIYLHC----CNPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQHKFAMTMC-GTPCWTAPEVLRNQRYTEKADVYSFAIVLWEC

LT
.|
VT
Kinase IRAKh_a-2.AA TK 45-209 14 5.4e-30 97.14 In-house 1-319 (486) Show / Hide 
Range on Protein: 45-209
Range on HMM: 1-319/486
Sequence Identity: 14% (46 aa)

FSYDNFIGEGGFG---RVYRGVLRTGK--------------------------PVAIKQMDPTLSRGTQGERE--------------FRVEVDLLS--RL
  . . .||| ||   .||.| .|...                          |||.|.. .. .   . ...              .  |  ...   .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

SHPSLVRLIGYCADR------------KQRMLVYEFMTQGS----LQEHLH--GIVRIK-----------------------------------------
 || .|||.|.| .             .  |.| |.|  |.    |...|.     ...                                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------MNWQVRIRIALGSARALEYLHAGPATGN--PIIHRDFKSSNILLDETFQ-----------AKVSDFG--
                               .. . .. ...  |...||||. . .     ..|||    |.|..|  .           .|..|||  
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

------LAKLVPHGNKTYVST
      ||. ....   |...
RQGSGVLARDIYSDDDYYRKS
Kinase IRAKh_a-2.AA LRRK 231-252 52 1e-06 19.28 In-house 262-284 (351) Show / Hide 
Range on Protein: 231-252
Range on HMM: 262-284/351
Sequence Identity: 52% (12 aa)

KSDVYAFGVVLLELLTGR-RPVD
|.|.|.||..| ||||.. .| |
KVDCYSFGMILWELLTRQHHPFD
Kinase IRAKh_a-2.AA TK 224-250 46 2e-06 16.51 In-house 367-394 (486) Show / Hide 
Range on Protein: 224-250
Range on HMM: 367-394/486
Sequence Identity: 46% (13 aa)

ATGRLTLKSDVYAFGVVLLELLT-GRRP
..|. | ||||..|||.. |..| |. |
KYGKFTTKSDVWSFGVLMWEIFTYGQEP
Kinase IRAKh_a-2.AA Pkinase 229-322 16 1.2e-05 21.05 Pfam 190-293 (293) Show / Hide 
Range on Protein: 229-322
Range on HMM: 190-293/293
Sequence Identity: 16% (19 aa)

TLKSDVYAFGVVLLELLTGRRPVDSAHSFTKQNLVFQVR----DSLRDSRKLKKIIDPEISLESCSWESI------------------KRFAMLAYCCVR
. |.|....|..| |.|.||             . |. .    . ...  ....| .|... ..  | ||                  . .  . ..| .
GPKVDMWSCGCILYEMLCGR-------------PPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLC

DDDTRRPTMGECVAE--L
 | ..|||  ...    .
KDPKKRPTAEQILQHPWF
Kinase IRAKh_a-2.AA LISK 231-250 40 3.9e-05 12.4 In-house 219-238 (296) Show / Hide 
Range on Protein: 231-250
Range on HMM: 219-238/296
Sequence Identity: 40% (8 aa)

KSDVYAFGVVLLELLTGRRP
..||. ||.||.|. |....
SCDVFSFGIVLCEIITRVKA
Kinase IRAKh_a-2.AA Pkinase_Tyr 224-250 46 0.000114 16.44 Pfam 187-214 (270) Show / Hide 
Range on Protein: 224-250
Range on HMM: 187-214/270
Sequence Identity: 46% (13 aa)

ATGRLTLKSDVYAFGVVLLELLT-GRRP
..|. | ||||..|||.. |..| |. |
NYGKFTTKSDVWSFGVLMWEIFTYGEQP
Kinase IRAKh_a-2.AA MLK 231-250 55 0.000179 11.58 In-house 216-235 (291) Show / Hide 
Range on Protein: 231-250
Range on HMM: 216-235/291
Sequence Identity: 55% (11 aa)

KSDVYAFGVVLLELLTGRRP
|.||. .|||| |.||.. |
KCDVWSWGVVLWEMLTREVP
Kinase IRAKh_a-2.AA Dicty4 231-250 60 0.000527 9.44 In-house 197-216 (277) Show / Hide 
Range on Protein: 231-250
Range on HMM: 197-216/277
Sequence Identity: 60% (12 aa)

KSDVYAFGVVLLELLTGRRP
|.||| || || |.||.  |
KADVYSFGIVLWEILTRQEP
Kinase IRAKh_a-2.AA DRK 297-324 35 0.000739 8.99 In-house 231-258 (258) Show / Hide 
Range on Protein: 297-324
Range on HMM: 231-258/258
Sequence Identity: 35% (10 aa)

FAMLAYCCVRDDDTRRPTMGECVAELEQ
.. |   |   | . ||.| ||.  || 
YIQLMNDCWNEDPQHRPSMQECLERLEA
Kinase IRAKh_a-2.AA TK 300-322 30 0.004885 5.17 In-house 464-486 (486) Show / Hide 
Range on Protein: 300-322
Range on HMM: 464-486/486
Sequence Identity: 30% (7 aa)

LAYCCVRDDDTRRPTMGECVAEL
|  .| . |  .|||. ... .|
LMQQCWHYDPEDRPTFSQLHEQL
Kinase IRAKh_a-2.AA Dicty4 310-324 29 0.005481 6.0 In-house 261-277 (277) Show / Hide 
Range on Protein: 310-324
Range on HMM: 261-277/277
Sequence Identity: 29% (5 aa)

TRRPTMGECVAE--LEQ
..||.. |.. .  || 
QHRPSFEEIIQRRILEH
Kinase IRAKh_a-2.AA MLK 295-322 25 0.063847 2.61 In-house 264-291 (291) Show / Hide 
Range on Protein: 295-322
Range on HMM: 264-291/291
Sequence Identity: 25% (7 aa)

KRFAMLAYCCVRDDDTRRPTMGECVAEL
.... |  .|  .|  .||.. ..| .|
EHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase IRAKh_a-2.AA Dicty4-Unclassified 304-322 36 0.181093 0.75 In-house 245-263 (263) Show / Hide 
Range on Protein: 304-322
Range on HMM: 245-263/263
Sequence Identity: 36% (7 aa)

CVRDDDTRRPTMGECVAEL
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CWHNDPNKRPTMNQIIQYL
Kinase IRAKh_a-2.AA Pkinase_Tyr 311-322 41 1.912495 2.13 Pfam 259-270 (270) Show / Hide 
Range on Protein: 311-322
Range on HMM: 259-270/270
Sequence Identity: 41% (5 aa)

RRPTMGECVAEL
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DRPTFSEIHEQL