Gene IRAKh_b-2 (S.moellendorffii)

IRAKh_b-2

Species: S.moellendorffii
Alias: IRAKh_b-2
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAKh

Sequence

Name Sequence Type Origin Length Description Download
IRAKh_b-2.AA Protein None 339 None Fasta, JSON
IRAKh_b-2.NA RNA None 1020 None Fasta, JSON
IRAKh_b-2.kin_dom Protein Kinase Domain None 206 None Fasta, JSON

Protein domain

Protein domains of IRAKh_b-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IRAKh_b-2.AA TKL 14-286 21 3.9e-64 219.39 In-house 1-364 (364) Show / Hide 
Range on Protein: 14-286
Range on HMM: 1-364/364
Sequence Identity: 21% (84 aa)

LGEGGFGRVYRGVLKN---------GQIVAVKQMEPSLSKGVQG-----------------------EREFRVEVD-ILSRLDHSHLVKLIGYCADKGQ-
.|.|||| ||.|....         |. ||||..    ..                           .|.|..|.  ..|||.| ..|...||| . .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------RMLVYEFMPHGNLQEHLHGIVRVKMDWRTRVSIARGAATALEYLHN-----GPATGNPVIHRDFKSSNILLDDKFQ------------
             ..|.|..|.|.| ..||        |  |...|...| ...|||.     .     |.|||| ||.|||.|....            
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCT--KPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD

--AKVSDFGLAK-LVPYGNQTYVSTR----------------VLGTFGYFDPQYTA----------------TGRLTLKSDVYAFGVVMLELLTGRRPVN
  .|..||||.. . . ||..  .|                 . ||...  |                     .  . |.|||.||.|. |.||..|   
WCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR---

ATYTLRKQN-LVTQVRDWLREKRKLKKILDPELRAELPWQWD----------SIRRFASLAFDCIRDDDTRRPTMSQCAREL
     ....    ...| . ..  .... |  || ..| .|             .....|. ||   | . ||.....  .|
---PYYDYPYMPMIFQD-P-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAKh_b-2.AA IRAK 8-214 39 1.4e-63 217.56 In-house 1-224 (317) Show / Hide 
Range on Protein: 8-214
Range on HMM: 1-224/317
Sequence Identity: 39% (89 aa)

FSSDNLLGEGGFGRVYRGVLKNGQ-IVAVK-QMEPSLSKGVQGEREFRV---EVDILSRLDHSHLVKLIGYCADKGQRMLVYEFMPHGNLQEHLHGIVRV
|. ||..|||||| ||||..||   |.|||  .|   ..  . ...|.    |. ...|. | ..| | |||.. ..  |||..|| | |.  |..    
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

KM----DWRTRVSIARGAATALEYLHNGP-ATGNPVIHRDFKSSNILLDDKFQAKVSDFGLAKLV-PYG---NQTY---VSTRVLGTFGYFDPQYTA--T
 .     | .|.||. |.| ....||.   .|  |.||.| ||.|||||. |..| .||||.    | .    |||      .| ||  |  | .    .
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCT--PIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQ

GRLTLKSDVYAFGVVMLELLTGRRPV
|.|| |.||| ||.| ||.|||.|.|
GQLTKKTDVYSFGIVLLEVLTGCRAV
Kinase IRAKh_b-2.AA TKL-Unique 12-213 30 2.2e-51 177.05 In-house 3-233 (290) Show / Hide 
Range on Protein: 12-213
Range on HMM: 3-233/290
Sequence Identity: 30% (72 aa)

NLLGEGGFGRVYRGVLKNGQIVAVKQMEPSLSKGV-QGEREFRVEVDILSRLD-HSHLVKLIGYCA----DKGQRMLVYEFMPHGNLQEHLHG-------
|..||||.|.||.|.  .| .||.|| .| ...   . ..||. || ....|. |  .|...|||.    . ... .| |..|.|.| ..||        
NKIGEGGYGQVYKGKW-RGYPVAIKQFHP-NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

-IVRVKMDWRTRVSIARGAATALEYLHNGPATGNPVIHRDFKSSNILLDDK-----FQAKVSDFGLAKLVPYGNQTYVS-------TRVLGTFGYFDPQY
 .   |...  ||..|. .| ...|||.   .. |.|||| ||||.|.| .     ...|..||||.|.    |.. ..       . ..|.| .  |. 
NNNNCKLNMQQRVKMAIDIAQGMYYLHH---CEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEV

TAT--GRLTLKSDVYAFGVVMLELLTGRR------P
.       . |||||.||.|. |..|. .      |
LRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKP
Kinase IRAKh_b-2.AA S_TKc 8-289 21 5.8e-39 136.67 SMART 1-231 (231) Show / Hide 
Range on Protein: 8-289
Range on HMM: 1-231/231
Sequence Identity: 21% (64 aa)

FSSDNLLGEGGFGRVYRGVLKN-GQIVAVKQMEPSLSKGVQGEREFRVEVDILSRLDHSHLVKLIGYCADKGQRMLVYEFMPH--GNLQEHLHGIVRVK-
.   ...|.|.||.||... |. |.|||.|..           . .| |..||.. .| ..|||.... | .   .| |....  |.| ....   | . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---MDWRTRVSIARGAATALEYLHNGPATGNPVIHRDFKSSNILLDDKFQAKVSDFGLAKLVPYGNQTYVSTR------VLGTFGYFDPQYTATGRLTL-
   ..  .  ....  . ||||.|.     . .|||| | .|||||.  . |..|||||...     |.. |.      ||                .  
RFPFPE-HARFYMYQICCALEYCHS-----HGIIHRDLKPENILLDE--HIKICDFGLARQL----TTFCGTPWYMAPEVL--------------GYGKC

KSDVYAFGVVMLELLTGRRPVNATYTLRKQNLVTQVRDWLREKRKLKKILDPELRAELPWQWDSIRRFASLAFDCIRDDDTRRPTMSQCAR-E-----LE
|.|....|... |.|.|. |   .. .  ....                                . . ..   | . | ..|||  .. . |      .
KCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG-------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHP

LL
 .
WF
Kinase IRAKh_b-2.AA TyrKc 8-286 22 6.8e-39 136.46 SMART 1-280 (280) Show / Hide 
Range on Protein: 8-286
Range on HMM: 1-280/280
Sequence Identity: 22% (71 aa)

FSSDNLLGEGGFGRVYRGVLKNGQIVAVKQMEPSLSKGVQGEREFRVEVDILSRL--DHSHLVKLIGYCADK-------GQRMLVYEFMPHGNLQEHLHG
 . .  |||| ||.||.|..|  . |||| . ..       ...|. |  |...|  .| ..|.|.|.| ..       .. |.| |.||||.|...|. 
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

IVRVKMDWRTRVSIARGAATALEYLHNGPATGNPVIHRDFKSSNILLDDKFQAKVSDFGLAKLVPYG------NQTYV-----STR-----------VLG
  .    ... .|..  .|   ||||       ..||||    |.|.......|.|||||.. .  .       ..|.     ...           .. 
HRPK-LCMKDLLSFCWQIACGMEYLHSK-----NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-

TFGYFDPQYTATGRLTLKSDVYAFGVVMLELLTGRRPVNATYTLRKQNLVTQVRDWLREKRKLKKILDPELRAELPWQW----DSIRRFASLAFDCIRDD
           .|. | ||||..|||.| |..|   .     ...     ..|. .... . ...  ...     |        .   .  .  .| . |
----------NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDY-----P--MSFVCCPDEMYQ-IMKQCWHED

DTRRPTMSQCAREL
   |||.|.. ...
PEDRPTFSEIHECF
Kinase IRAKh_b-2.AA Pkinase 8-173 26 4.8e-38 135.59 Pfam 1-175 (293) Show / Hide 
Range on Protein: 8-173
Range on HMM: 1-175/293
Sequence Identity: 26% (48 aa)

FSSDNLLGEGGFGRVYRGVLKNGQI-VAVKQMEPSLSKGVQGEREFR-VEVDILSRLDHSHLVKLIGYCADKGQRMLVYEFMPHG----NLQEHLHGIVR
.     .|.|.||.||... |. .. ||||... .  |  . .. .|  |. |. ||.| . |.|.... ||.   .| |....|     | .....  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

VKM--DWRTRVSIARGAATALEYLHNGPATGNPVIHRDFKSSNILLDDKFQA----KVSDFGLAK---LVPYGNQTYVSTR
 ..  ....  ....  . .|||.|.       .|||| |..|||.|.. .     |..||||||   . .....|.. |.
GCFYFSEWECKFYMYQILRGLEYCHSM-----GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNSMTTFCGTP
Kinase IRAKh_b-2.AA LRRK 8-213 26 4.9e-38 132.16 In-house 1-282 (351) Show / Hide 
Range on Protein: 8-213
Range on HMM: 1-282/351
Sequence Identity: 26% (76 aa)

FSSDNLLGEGGFG-RVYRGVLKN---------------------------GQIVAVKQMEPS-------------------------------LSKGVQG
. . ...|.|||| .|||. ...                           .| ||.|...                                 ..     
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

EREFRVEVDILSRLDHSHLVKLIGYCADKGQRMLVYEFMPHGNLQEHLHGIVRVK-------MDWRTRVSIARGAATALEYLHNGPATGN-PVIHRDFKS
 |||| || |.|.|.|...|.|.|.| .   ...| |..|||.|...||   . .       ..| ..  ||   | ..||||.     | |.|||| ||
FREFRHEVWIMSHLNHPNIVSLKGFCIH--PLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHS----HNPPIIHRDLKS

SNILL---D---------DKFQAKVSDFGLAK---LVPYGNQTYVSTRVLGTFGYFDP---QYTATGRLTLKSDVYAFGVVMLELLTGR-RP
 ||||   .         .   ||..|||.      ...|    |  ...|..|.  |   .|. .   | |.|.|.||... ||||.. .|
PNILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMG----VAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHP
Kinase IRAKh_b-2.AA Pkinase_Tyr 8-172 27 1.3e-37 127.96 Pfam 1-171 (270) Show / Hide 
Range on Protein: 8-172
Range on HMM: 1-171/270
Sequence Identity: 27% (49 aa)

FSSDNLLGEGGFGRVYRGVLK-----NGQIVAVKQMEPSLSKGVQGE---REFRVEVDILSRL-DHSHLVKLIGYCA-DKGQ--RMLVYEFMPHGNLQEH
 . .  |||| ||.||.|..|     ... |||| . .   .  . .   ..|  |. |.. | .| ..|.|.| |  ....   ..| |.||||.| ..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE---GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

LHGI--VRVKMDWRTRVSIARGAATALEYLHNGPATGNPVIHRDFKSSNILLDDKFQAKVSDFGLAKLVPYGNQTY-VST
|.     . . .  . .....  | ..|||.. .      ||||    |.|.......|..|||||... |   .| ...
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN-----CIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYYYRKR
Kinase IRAKh_b-2.AA Dicty4 8-160 32 9.9e-34 110.0 In-house 1-162 (277) Show / Hide 
Range on Protein: 8-160
Range on HMM: 1-162/277
Sequence Identity: 32% (55 aa)

FSSDNLLGEGGFGRVYRGVLKNGQIVAVKQMEPSLSKGVQGER--EFRVEVDILSRLDHSHLVKLIGYCA----DKGQRMLVYEFMPHGNLQEHLHG---
   ....|.|.|| ||.|  . |..|||| . ...  ..  ..  ||| ||.|.. . | ..... |.|      .|  . | |.|| ||| . ||    
INIEQRIGKGSFGEVYKGTWR-GKEVAVKKL-NNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPS

--IVRVKMDWRTRVS---IARGAATALEYLHN-GPATGNPVIHRDFKSSNILLDDKFQAKVSDFGLAK
    ..|.|| .. .   .|. ||  . .||.  |     .|||| ||.|.| |. ...||.||||..
EQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV----IIHRDLKSHNLLVDKNWRVKVCDFGLSQ
Kinase IRAKh_b-2.AA TK 8-172 14 1.1e-32 106.34 In-house 1-319 (486) Show / Hide 
Range on Protein: 8-172
Range on HMM: 1-319/486
Sequence Identity: 14% (45 aa)

FSSDNLLGEGGFG---RVYRGVLKNG--------------------------QIVAVKQMEPSLSKGVQGERE--------------FRVEVDILS--RL
    . |||| ||   .||.| ....                          . ||||.. .  .   . ...              .  |  ...   .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

DHSHLVKLIGYCADK------------GQRMLVYEFMPHGN----LQEHLH--GIVRVK-----------------------------------------
.| ..|.|.|.| ..            .  |.| |.||||.    |...|.     . .                                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------MDWRTRVSIARGAATALEYLHNGPATGN--PVIHRDFKSSNILLDDKFQ-----------AKVSDFG--
                               .. .... ... .| ..||||  . .     ..|||    |.|.... .           .|..|||  
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

------LAKLVPYGNQTYVST
      ||. ....   |...
RQGSGVLARDIYSDDDYYRKS
Kinase IRAKh_b-2.AA MLK 8-160 26 3e-31 105.71 In-house 1-181 (291) Show / Hide 
Range on Protein: 8-160
Range on HMM: 1-181/291
Sequence Identity: 26% (49 aa)

FSSDNLLGEGGFGRVYRGVLKNGQ----IVAVKQME--PSLSKGVQG--EREFRVEVDILSRLDHSH----LVKLIGYCADKGQ-RMLVYEFMPHGNLQE
.     .|.|.|| |..|. .|      |||||. .  .  .|.. .   ..|. |. .|..|.|       ... | |.. ..   .| |....| | .
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

HLHGIVR------------VKMDWRTRVSIARGAATALEYLHN-GPATGNPVIHRDFKSSNILLDD------KFQAKVSDFGLAK
 |||.              . .|    ...|   | ...|||.  |    |.|||| ||.|||.|.      . ..|..|||...
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPK---PIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSR
Kinase IRAKh_b-2.AA TK-Unique 8-160 24 6.7e-30 100.34 In-house 1-181 (294) Show / Hide 
Range on Protein: 8-160
Range on HMM: 1-181/294
Sequence Identity: 24% (46 aa)

FSSDNLLGEGGFGRVYRGVLKN-------GQIVAVKQMEPSLSKGVQGEREFRVEVDILSRLD-HSHLVKLIGYCADKG-QRMLVYEFMPHGNLQEHLHG
.  ....||| || |.|| ...        ..||||. . ...   . ...|  |  ... |. | ..|...|.| ... . |...|..| |||| .|. 
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNAT--DTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRT

IVRV-----------------KMDWRTR-VS------IARGAATALEYLHNGPATGNPVIHRDFKSSNILLDDKFQAKVSDFGLAK
  ..                 ... ||  .|      .| . | ..|||.  .     ..|||  ..|.|| .....|..|||.|.
CRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQR---KKIVHRDLCARNVLLTEDKVCKICDFGMAR
Kinase IRAKh_b-2.AA Dicty4-Unclassified 11-213 33 1.3e-29 98.56 In-house 4-207 (263) Show / Hide 
Range on Protein: 11-213
Range on HMM: 4-207/263
Sequence Identity: 33% (73 aa)

DNLLGEGGFGRVYRGVLKNGQIVAVKQMEPSLSKGVQGER-----EFRVEVDILSRLDHSHLVKLIGYC-AD---KGQRMLVYEFMPHGNLQEHLH----
|  .|.| | .|..|. | |  ||||     .  .    |     .|. ||.||  . |  |||. ||| .    |   . | |||. ||| |  |    
DQFIGKGHFSKVHKGNWK-GKDVAVKK----FNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPS

-GIVRVKMDWRTRVSIARGAATALEYLHNGPATGNPVIHRDFKSSNILLDDKFQAKVSDFGLAKLVPYGNQTYVSTRVLGTFGYFDPQYTATGRLTLKSD
     .|.|    . .|   |  . .||    | | .|||| ||||||.|  | .|. |||..  . .   ..  | . ||     |        . |||
EQQQPIKLDDTLIIKYAFDIAQGMQHLH----TRN-FIHRDIKSSNILMDKHFNIKIADFGISRVIDF---NFNMTTIAGTPKWESPECLMHESYNQKSD

VYAFGVVMLELLTGRRP
|| ..... ||.||  |
VYSYAMMLYELATGDEP
Kinase IRAKh_b-2.AA LISK 13-162 30 1.4e-29 93.12 In-house 1-155 (296) Show / Hide 
Range on Protein: 13-162
Range on HMM: 1-155/296
Sequence Identity: 30% (49 aa)

LLGEGGFGRVYRGVLK-NGQIVAVKQME--PSLSKGVQGEREFRVEVDILSRLDHSHLVKLIGYCAD-KGQRMLVYEFMPHGNLQEHLH-GIV-RVKMDW
 .|.|.|| ||.| ..  || .|.|. .  |  ..    .. .  || .. .|.| . |. .| |   .|| ..| |..  |.|.. |.   .  .   |
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW

RTRVSIARGAATALEYLHNGPATGNPVIHRDFKSSNILLDDK----FQAKVSDFGLAKLV
. ||.||.. | ...|||      . .|||| || |.|....    ...|| |||.|...
PQRVKIALDIACGMSYLHS-----MNIIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMM
Kinase IRAKh_b-2.AA TK 187-213 50 2e-06 17.09 In-house 367-394 (486) Show / Hide 
Range on Protein: 187-213
Range on HMM: 367-394/486
Sequence Identity: 50% (14 aa)

ATGRLTLKSDVYAFGVVMLELLT-GRRP
..|. | ||||..|||.| |..| |. |
KYGKFTTKSDVWSFGVLMWEIFTYGQEP
Kinase IRAKh_b-2.AA Pkinase 192-289 17 5e-06 22.45 Pfam 190-293 (293) Show / Hide 
Range on Protein: 192-289
Range on HMM: 190-293/293
Sequence Identity: 17% (20 aa)

TLKSDVYAFGVVMLELLTGRRPVNATYTLRKQNLVTQVRDWLREKRKLKKILDPELRAELPWQWDSI------------------RRFASLAFDCIRDDD
. |.|....|... |.|.||        .  .. . .  . .... ....|..|.|. . || |.||                  . . ..  .|.. | 
GPKVDMWSCGCILYEMLCGR--------PPFPGHC-WHDN-HDQMQMICRIMGPPLHFDWPW-WCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDP

TRRPTMSQCARELELL
..|||  ... . . .
KKRPT-AEQILQHPWF
Kinase IRAKh_b-2.AA Pkinase_Tyr 187-213 50 8.6e-05 16.85 Pfam 187-214 (270) Show / Hide 
Range on Protein: 187-213
Range on HMM: 187-214/270
Sequence Identity: 50% (14 aa)

ATGRLTLKSDVYAFGVVMLELLT-GRRP
..|. | ||||..|||.| |..| |. |
NYGKFTTKSDVWSFGVLMWEIFTYGEQP
Kinase IRAKh_b-2.AA LISK 194-215 31 9.3e-05 11.16 In-house 219-240 (296) Show / Hide 
Range on Protein: 194-215
Range on HMM: 219-240/296
Sequence Identity: 31% (7 aa)

KSDVYAFGVVMLELLTGRRPVN
..||. ||.|..|. |.... .
SCDVFSFGIVLCEIITRVKADP
Kinase IRAKh_b-2.AA TK-Unique 192-209 61 0.000266 10.88 In-house 217-234 (294) Show / Hide 
Range on Protein: 192-209
Range on HMM: 217-234/294
Sequence Identity: 61% (11 aa)

TLKSDVYAFGVVMLELLT
| ||||..|||.| |..|
TTKSDVWSFGVLMWEIFT
Kinase IRAKh_b-2.AA MLK 194-213 50 0.000388 10.4 In-house 216-235 (291) Show / Hide 
Range on Protein: 194-213
Range on HMM: 216-235/291
Sequence Identity: 50% (10 aa)

KSDVYAFGVVMLELLTGRRP
|.||. .|||. |.||.. |
KCDVWSWGVVLWEMLTREVP
Kinase IRAKh_b-2.AA TK 267-286 40 0.002045 6.46 In-house 467-486 (486) Show / Hide 
Range on Protein: 267-286
Range on HMM: 467-486/486
Sequence Identity: 40% (8 aa)

DCIRDDDTRRPTMSQCAREL
.| . |  .|||.||. ..|
QCWHYDPEDRPTFSQLHEQL
Kinase IRAKh_b-2.AA TK-Unique 268-286 26 0.006974 5.92 In-house 276-294 (294) Show / Hide 
Range on Protein: 268-286
Range on HMM: 276-294/294
Sequence Identity: 26% (5 aa)

CIRDDDTRRPTMSQCAREL
|.... . ||. .|.. .|
CWQWEPEERPSFRQIKHRL
Kinase IRAKh_b-2.AA Dicty4-Unclassified 263-286 37 0.0081 5.44 In-house 240-263 (263) Show / Hide 
Range on Protein: 263-286
Range on HMM: 240-263/263
Sequence Identity: 37% (9 aa)

SLAFDCIRDDDTRRPTMSQCAREL
.|  .|  .|  .|||| |    |
KLIKWCWHNDPNKRPTMNQIIQYL
Kinase IRAKh_b-2.AA MLK 259-286 25 0.014248 4.9 In-house 264-291 (291) Show / Hide 
Range on Protein: 259-286
Range on HMM: 264-291/291
Sequence Identity: 25% (7 aa)

RRFASLAFDCIRDDDTRRPTMSQCAREL
.....|  .|  .|  .||...|.  .|
EHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase IRAKh_b-2.AA Dicty4 194-213 55 0.018662 4.2 In-house 197-216 (277) Show / Hide 
Range on Protein: 194-213
Range on HMM: 197-216/277
Sequence Identity: 55% (11 aa)

KSDVYAFGVVMLELLTGRRP
|.||| || |  |.||.  |
KADVYSFGIVLWEILTRQEP
Kinase IRAKh_b-2.AA Dicty4 274-288 23 0.065742 2.35 In-house 261-277 (277) Show / Hide 
Range on Protein: 274-288
Range on HMM: 261-277/277
Sequence Identity: 23% (4 aa)

TRRPTMSQCARE--LEL
..||.....  .  || 
QHRPSFEEIIQRRILEH
Kinase IRAKh_b-2.AA Pkinase_Tyr 275-286 41 0.685124 3.64 Pfam 259-270 (270) Show / Hide 
Range on Protein: 275-286
Range on HMM: 259-270/270
Sequence Identity: 41% (5 aa)

RRPTMSQCAREL
.|||.|.. ..|
DRPTFSEIHEQL