IRAKh_b-1

Species: S.moellendorffii
Alias: IRAKh_b-1
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAKh

Sequence

Name Sequence Type Origin Length Description Download
IRAKh_b-1.AA Protein None 259 None Fasta, JSON
IRAKh_b-1.NA RNA None 780 None Fasta, JSON
IRAKh_b-1.kin_dom Protein Kinase Domain None 156 None Fasta, JSON

Protein domain

Protein domains of IRAKh_b-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IRAKh_b-1.AA TKL 12-243 21 2e-50 173.85 In-house 68-364 (364) Show / Hide
Range on Protein: 12-243
Range on HMM: 68-364/364
Sequence Identity: 21% (69 aa)

EREFRVEVD-ILSRLDHSHLVKLIGYCADKGQ-------------RMLVYEFMPHGNLQEHLHGIVRVKMDWRTRVSIARGAATALEYLHN-----GPAT
.|.|..|.  ..|||.| ..|...||| . ..              ..|.|..|.|.| ..||        |  |...|...| ...|||.     .   
FRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCT--

GNPVIHRDFKSSNILLDDKFQ--------------AKVSDFGLAK-LVPYGNQTYVSTR----------------VLGTFGYFDPQLTLKS---------
  |.|||| ||.|||.|....              .|..||||.. . . ||..  .|                 . ||...  | .  ..         
KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGI

-------------DVYAFGVVMLELLTGRRPVNATYTLRKQNLVTQVQDWLREK------RKLKKILDPELRAELPWQWD----------SIRRFASLAF
             |||.||.|. |.||..|             . . ..   ..        .... |  || ..| .|             .....|. 
DEFCKGFEYSEKCDVYSFGIVLWEILTRCR-------------PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQ

DCIRDDDTRRPTMSQCAREL
||   | . ||.....  .|
DCWDHDPEKRPSFQEILKRL

Kinase IRAKh_b-1.AA TKL-Unique 12-170 28 1e-39 137.73 In-house 39-233 (290) Show / Hide
Range on Protein: 12-170
Range on HMM: 39-233/290
Sequence Identity: 28% (56 aa)

EREFRVEVDILSRLD-HSHLVKLIGYCA----DKGQRMLVYEFMPHGNLQEHLHG--------IVRVKMDWRTRVSIARGAATALEYLHNGPATGNPVIH
..||. || ....|. |  .|...|||.    . ... .| |..|.|.| ..||         .   |...  ||..|. .| ...|||.   .. |.||
MQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHH---CEPPIIH

RDFKSSNILLDDK-----FQAKVSDFGLAKLVPYGNQTYVS-------TRVLGTFGYFDPQLTLK--------SDVYAFGVVMLELLTGRR------P
|| ||||.|.| .     ...|..||||.|.    |.. ..       . ..|.| .  |...          ||||.||.|. |..|. .      |
RDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKP

Kinase IRAKh_b-1.AA Pkinase 12-246 20 2.2e-33 119.12 Pfam 42-293 (293) Show / Hide
Range on Protein: 12-246
Range on HMM: 42-293/293
Sequence Identity: 20% (57 aa)

EREFRV--EVDILSRLDHSHLVKLIGYCADKGQRMLVYEFMPHG----NLQEHLHGIVRVKM--DWRTRVSIARGAATALEYLHNGPATGNPVIHRDFKS
... |   |. |. ||.| . |.|.... ||.   .| |....|     | .....  . ..  ....  ....  . .|||.|.       .|||| |.
DQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM-----GIIHRDLKP

SNILLDDKFQA----KVSDFGLAK---LVPYGNQTYVSTR------VLGTFGYFDPQLTLKSDVYAFGVVMLELLTGRRPVNATYTLRKQNLVTQVQDWL
.|||.|.. .     |..||||||   . .....|.. |.      |.     ...  . |.|....|... |.|.||        .  .. . .  . .
ENILIDNNGHIDACVKICDFGLAKQFDY-NNSMTTFCGTPWYMAPEVIR----GGQYYGPKVDMWSCGCILYEMLCGR--------PPFPGHC-WHDN-H

REKRKLKKILDPELRAELPWQWDSI------------------RRFASLAFDCIRDDDTRRPTMSQCARELELL
... ....|..|.|. . || |.||                  . . ..  .|.. | ..|||  ... . . .
DQMQMICRIMGPPLHFDWPW-WCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-AEQILQHPWF

Kinase IRAKh_b-1.AA IRAK 12-122 36 4e-33 114.79 In-house 44-160 (317) Show / Hide
Range on Protein: 12-122
Range on HMM: 44-160/317
Sequence Identity: 36% (43 aa)

EREFRV---EVDILSRLDHSHLVKLIGYCADKGQRMLVYEFMPHGNLQEHLHGIVRVKM----DWRTRVSIARGAATALEYLHNGP-ATGNPVIHRDFKS
...|.    |. ...|. | ..| | |||.. ..  |||..|| | |.  |..     .     | .|.||. |.| ....||.   .|  |.||.| ||
WQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQCPPKPLSWHQRCSICWGTACGIQFLHQNHPCT--PIIHGDIKS

SNILLDDKFQAKVSDFGLA
.|||||. |..| .||||.
ANILLDQHFTPKICDFGLH

Kinase IRAKh_b-1.AA LRRK 13-170 32 3.7e-29 100.28 In-house 102-282 (351) Show / Hide
Range on Protein: 13-170
Range on HMM: 102-282/351
Sequence Identity: 32% (63 aa)

REFRVEVDILSRLDHSHLVKLIGYCADKGQRMLVYEFMPHGNLQEHLHGIVRVK-------MDWRTRVSIARGAATALEYLHNGPATGN-PVIHRDFKSS
|||| || |.|.|.|...|.|.|.| .   ...| |..|||.|...||   . .       ..| ..  ||   | ..||||.     | |.|||| || 
REFRHEVWIMSHLNHPNIVSLKGFCIH--PLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHS----HNPPIIHRDLKSP

NILL---D---------DKFQAKVSDFGLAK---LVPYGNQTYVSTRVLGTFGYFDP---------QLTLKSDVYAFGVVMLELLTGR-RP
||||   .         .   ||..|||.      ...|    |  ...|..|.  |         . | |.|.|.||... ||||.. .|
NILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMG----VAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHP

Kinase IRAKh_b-1.AA Dicty4 14-123 34 1.4e-27 89.19 In-house 44-162 (277) Show / Hide
Range on Protein: 14-123
Range on HMM: 44-162/277
Sequence Identity: 34% (43 aa)

EFRVEVDILSRLDHSHLVKLIGYCA----DKGQRMLVYEFMPHGNLQEHLHG-----IVRVKMDWRTRVS---IARGAATALEYLHN-GPATGNPVIHRD
||| ||.|.. . | ..... |.|      .|  . | |.|| ||| . ||        ..|.|| .. .   .|. ||  . .||.  |     .||||
EFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV----IIHRD

FKSSNILLDDKFQAKVSDFGLAK
 ||.|.| |. ...||.||||..
LKSHNLLVDKNWRVKVCDFGLSQ

Kinase IRAKh_b-1.AA TK 14-170 14 3.5e-27 87.55 In-house 87-394 (486) Show / Hide
Range on Protein: 14-170
Range on HMM: 87-394/486
Sequence Identity: 14% (46 aa)

EFRVEVDILS--RLDHSHLVKLIGYCADK------------GQRMLVYEFMPHGN----LQEHLH--GIVRVK---------------------------
|.  |  ...   ..| ..|.|.|.| ..            .  |.| |.||||.    |...|.     . .                           
EEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITY

---------------------------------------------MDWRTRVSIARGAATALEYLHNGPATGN--PVIHRDFKSSNILLDDKFQ------
                                             .. .... ... .| ..||||  . .     ..|||    |.|.... .      
SHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNCLVGENNVCKWHFD

-----AKVSDFG--------LAKLVPYGNQTYVST--------------------------RV------LGTFGYF-------DPQLTLKSDVYAFGVVM
     .|..|||        ||. ....   |...                          ..        .. .        .   | ||||..|||.|
GCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLM

LELLT-GRRP
 |..| |. |
WEIFTYGQEP

Kinase IRAKh_b-1.AA Pkinase_Tyr 13-135 26 2.6e-26 89.71 Pfam 48-171 (270) Show / Hide
Range on Protein: 13-135
Range on HMM: 48-171/270
Sequence Identity: 26% (35 aa)

REFRVEVDILSRL-DHSHLVKLIGYCA-DKGQ--RMLVYEFMPHGNLQEHLHGI--VRVKMDWRTRVSIARGAATALEYLHNGPATGNPVIHRDFKSSNI
..|  |. |.. | .| ..|.|.| |  ....   ..| |.||||.| ..|.     . . .  . .....  | ..|||.. .      ||||    |.
EDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN-----CIHRDLAARNC

LLDDKFQAKVSDFGLAKLVPYGNQTY-VST
|.......|..|||||... |   .| ...
LVTENNVVKICDFGLARDI-YNDDYYYRKR

Kinase IRAKh_b-1.AA Dicty4-Unclassified 14-170 34 1.4e-24 81.06 In-house 44-207 (263) Show / Hide
Range on Protein: 14-170
Range on HMM: 44-207/263
Sequence Identity: 34% (60 aa)

EFRVEVDILSRLDHSHLVKLIGYC-AD---KGQRMLVYEFMPHGNLQEHLH-----GIVRVKMDWRTRVSIARGAATALEYLHNGPATGNPVIHRDFKSS
.|. ||.||  . |  |||. ||| .    |   . | |||. ||| |  |         .|.|    . .|   |  . .||    | | .|||| |||
DFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQPIKLDDTLIIKYAFDIAQGMQHLH----TRN-FIHRDIKSS

NILLDDKFQAKVSDFGLAKLVPYGNQTYVSTRVLGTFGYFDPQL------TLKSDVYAFGVVMLELLTGRRP
|||.|  | .|. |||..  . .   ..  | . ||     |        . ||||| ..... ||.||  |
NILMDKHFNIKIADFGISRVIDF---NFNMTTIAGTPKWESPECLMHESYNQKSDVYSYAMMLYELATGDEP

Kinase IRAKh_b-1.AA LISK 18-125 32 2.2e-22 69.37 In-house 46-155 (296) Show / Hide
Range on Protein: 18-125
Range on HMM: 46-155/296
Sequence Identity: 32% (37 aa)

EVDILSRLDHSHLVKLIGYCAD-KGQRMLVYEFMPHGNLQEHLH-GIV-RVKMDWRTRVSIARGAATALEYLHNGPATGNPVIHRDFKSSNILLDDK---
|| .. .|.| . |. .| |   .|| ..| |..  |.|.. |.   .  .   |. ||.||.. | ...|||      . .|||| || |.|....   
EVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPWPQRVKIALDIACGMSYLHS-----MNIIHRDLKSKNCLVRENDNN

-FQAKVSDFGLAKLV
 ...|| |||.|...
QWRIKVCDFGFARMM

Kinase IRAKh_b-1.AA MLK 13-123 26 2.3e-21 70.99 In-house 50-181 (291) Show / Hide
Range on Protein: 13-123
Range on HMM: 50-181/291
Sequence Identity: 26% (36 aa)

REFRVEVDILSRLDHSH----LVKLIGYCADKGQ-RMLVYEFMPHGNLQEHLHGIVR------------VKMDWRTRVSIARGAATALEYLHN-GPATGN
..|. |. .|..|.|       ... | |.. ..   .| |....| | . |||.              . .|    ...|   | ...|||.  |    
WDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPK---

PVIHRDFKSSNILLDD------KFQAKVSDFGLAK
|.|||| ||.|||.|.      . ..|..|||...
PIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSR

Kinase IRAKh_b-1.AA TK-Unique 12-123 24 2.6e-21 70.35 In-house 47-181 (294) Show / Hide
Range on Protein: 12-123
Range on HMM: 47-181/294
Sequence Identity: 24% (34 aa)

EREFRVEVDILSRLD-HSHLVKLIGYCADKG-QRMLVYEFMPHGNLQEHLHGIVRV-----------------KMDWRTR-VS------IARGAATALEY
...|  |  ... |. | ..|...|.| ... . |...|..| |||| .|.   ..                 ... ||  .|      .| . | ..||
KQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEY

LHNGPATGNPVIHRDFKSSNILLDDKFQAKVSDFGLAK
|.  .     ..|||  ..|.|| .....|..|||.|.
LASQR---KKIVHRDLCARNVLLTEDKVCKICDFGMAR

TyrKc IRAKh_b-1.AA TyrKc 5-243 19 1.4e-16 45.33 SMART 1-280 (280) Show / Hide
Range on Protein: 5-243
Range on HMM: 1-280/280
Sequence Identity: 19% (59 aa)

LS---------------------------KGVQGEREFRVEVDILSRL--DHSHLVKLIGYCADK-------GQRMLVYEFMPHGNLQEHLHGIVRVKMD
..                           |    ...|. |  |...|  .| ..|.|.|.| ..       .. |.| |.||||.|...|.   .    
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK-LC

WRTRVSIARGAATALEYLHNGPATGNPVIHRDFKSSNILLDDKFQAKVSDFGLAKLVPYG------NQTYV-----STR-----------VLGTFGYFDP
... .|..  .|   ||||       ..||||    |.|.......|.|||||.. .  .       ..|.     ...           ..  .| |  
MKDLLSFCWQIACGMEYLHSK-----NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKF--

QLTLKSDVYAFGVVMLELLTGRRPVNATYTLRKQNLVTQVQDWLREKRKLKKILDPELRAELPWQW----DSIRRFASLAFDCIRDDDTRRPTMSQCARE
  | ||||..|||.| |..|   .     ...     ..|  .... . ...  ...     |        .   .  .  .| . |   |||.|.. ..
--TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDY-----P--MSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHEC

L
.
F

S_TKc IRAKh_b-1.AA S_TKc 7-246 19 2e-15 49.36 SMART 17-231 (231) Show / Hide
Range on Protein: 7-246
Range on HMM: 17-231/231
Sequence Identity: 19% (53 aa)

KGVQGE-----------REFRVEVDILSRLDHSHLVKLIGYCADKGQRMLVYEFMPH--GNLQEHLHGIVRVK----MDWRTRVSIARGAATALEYLHNG
|..  .           . .| |..||.. .| ..|||.... | .   .| |....  |.| ....   | .    ..  .  ....  . ||||.|. 
KCRHKKTGRIVAIKIIKEHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHS-

PATGNPVIHRDFKSSNILLDDKFQAKVSDFGLAKLVPYGNQTYVSTR------VLGTFGYFDPQLTL-KSDVYAFGVVMLELLTGRRPVNATYTLRKQNL
    . .|||| | .|||||.  . |..|||||...     |.. |.      ||        . .  |.|....|... |.|.|. |   .. .  ...
----HGIIHRDLKPENILLDE--HIKICDFGLARQL----TTFCGTPWYMAPEVL--------GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKI

VTQVQDWLREKRKLKKILDPELRAELPWQWDSIRRFASLAFDCIRDDDTRRPTMSQCAR-E-----LELL
.                                . . ..   | . | ..|||  .. . |      . .
G-------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase IRAKh_b-1.AA IRAK 147-171 68 3.9e-09 28.68 In-house 200-224 (317) Show / Hide
Range on Protein: 147-171
Range on HMM: 200-224/317
Sequence Identity: 68% (17 aa)

QLTLKSDVYAFGVVMLELLTGRRPV
||| |.||| ||.| ||.|||.|.|
QLTKKTDVYSFGIVLLEVLTGCRAV

Kinase IRAKh_b-1.AA LISK 151-172 31 9.3e-05 11.16 In-house 219-240 (296) Show / Hide
Range on Protein: 151-172
Range on HMM: 219-240/296
Sequence Identity: 31% (7 aa)

KSDVYAFGVVMLELLTGRRPVN
..||. ||.|..|. |.... .
SCDVFSFGIVLCEIITRVKADP

Kinase IRAKh_b-1.AA TK-Unique 149-166 61 0.000266 10.88 In-house 217-234 (294) Show / Hide
Range on Protein: 149-166
Range on HMM: 217-234/294
Sequence Identity: 61% (11 aa)

TLKSDVYAFGVVMLELLT
| ||||..|||.| |..|
TTKSDVWSFGVLMWEIFT

Kinase IRAKh_b-1.AA MLK 151-170 50 0.000388 10.4 In-house 216-235 (291) Show / Hide
Range on Protein: 151-170
Range on HMM: 216-235/291
Sequence Identity: 50% (10 aa)

KSDVYAFGVVMLELLTGRRP
|.||. .|||. |.||.. |
KCDVWSWGVVLWEMLTREVP

Kinase IRAKh_b-1.AA Pkinase_Tyr 149-170 56 0.000537 14.16 Pfam 192-214 (270) Show / Hide
Range on Protein: 149-170
Range on HMM: 192-214/270
Sequence Identity: 56% (13 aa)

TLKSDVYAFGVVMLELLT-GRRP
| ||||..|||.| |..| |. |
TTKSDVWSFGVLMWEIFTYGEQP

Kinase IRAKh_b-1.AA TK 224-243 40 0.002045 6.46 In-house 467-486 (486) Show / Hide
Range on Protein: 224-243
Range on HMM: 467-486/486
Sequence Identity: 40% (8 aa)

DCIRDDDTRRPTMSQCAREL
.| . |  .|||.||. ..|
QCWHYDPEDRPTFSQLHEQL

Kinase IRAKh_b-1.AA TK-Unique 225-243 26 0.006974 5.92 In-house 276-294 (294) Show / Hide
Range on Protein: 225-243
Range on HMM: 276-294/294
Sequence Identity: 26% (5 aa)

CIRDDDTRRPTMSQCAREL
|.... . ||. .|.. .|
CWQWEPEERPSFRQIKHRL

Kinase IRAKh_b-1.AA Dicty4-Unclassified 220-243 37 0.0081 5.44 In-house 240-263 (263) Show / Hide
Range on Protein: 220-243
Range on HMM: 240-263/263
Sequence Identity: 37% (9 aa)

SLAFDCIRDDDTRRPTMSQCAREL
.|  .|  .|  .|||| |    |
KLIKWCWHNDPNKRPTMNQIIQYL

Kinase IRAKh_b-1.AA MLK 216-243 25 0.014248 4.9 In-house 264-291 (291) Show / Hide
Range on Protein: 216-243
Range on HMM: 264-291/291
Sequence Identity: 25% (7 aa)

RRFASLAFDCIRDDDTRRPTMSQCAREL
.....|  .|  .|  .||...|.  .|
EHWKKLMKQCWNQDPHKRPSFRQIVQHL

Kinase IRAKh_b-1.AA Dicty4 151-170 55 0.018662 4.2 In-house 197-216 (277) Show / Hide
Range on Protein: 151-170
Range on HMM: 197-216/277
Sequence Identity: 55% (11 aa)

KSDVYAFGVVMLELLTGRRP
|.||| || |  |.||.  |
KADVYSFGIVLWEILTRQEP

Kinase IRAKh_b-1.AA Dicty4 231-245 23 0.065742 2.35 In-house 261-277 (277) Show / Hide
Range on Protein: 231-245
Range on HMM: 261-277/277
Sequence Identity: 23% (4 aa)

TRRPTMSQCARE--LEL
..||.....  .  || 
QHRPSFEEIIQRRILEH

Kinase IRAKh_b-1.AA Pkinase_Tyr 232-243 41 0.685124 3.64 Pfam 259-270 (270) Show / Hide
Range on Protein: 232-243
Range on HMM: 259-270/270
Sequence Identity: 41% (5 aa)

RRPTMSQCAREL
.|||.|.. ..|
DRPTFSEIHEQL