Gene IRAKj_b-1 (S.moellendorffii)

IRAKj_b-1

Species: S.moellendorffii
Alias: IRAKj_b-1
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAKj

Sequence

Name Sequence Type Origin Length Description Download
IRAKj_b-1.AA Protein None 963 None Fasta, JSON
IRAKj_b-1.NA RNA None 2892 None Fasta, JSON
IRAKj_b-1.kin_dom Protein Kinase Domain None 204 None Fasta, JSON

Protein domain

Protein domains of IRAKj_b-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LRRNT_2 IRAKj_b-1.AA LRRNT_2 24-62 22 0.000857 15.22 Pfam 1-46 (46) Show / Hide 
Range on Protein: 24-62
Range on HMM: 1-46/46
Sequence Identity: 22% (11 aa)

DPVDAEALQSFQKGLSN-GE----ILQWS----GTDPCGAAWKHVQCR
.. |..||..| ..|..        . |.    ..|.|   |. | | 
HNDDGQALLAFKSSLNDSDPHHGVLSSWNPSSSDSDCCS--WTGVTCD
LRR_1 IRAKj_b-1.AA LRR_1 89-110 29 0.043601 11.57 Pfam 1-26 (26) Show / Hide 
Range on Protein: 89-110
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

NLEYLGMQG-N--ALSGSMPS--LAGM
||..| ..| |   |.|. |.  . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKj_b-1.AA LRR_1 112-134 25 0.100765 10.28 Pfam 1-26 (26) Show / Hide 
Range on Protein: 112-134
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

NLKIAYFDN-N--DFS-SIPGDFFAGL
||.. .... |   .. .|| . | .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKj_b-1.AA LRR_1 136-162 22 0.023835 12.5 Pfam 1-26 (26) Show / Hide 
Range on Protein: 136-162
Range on HMM: 1-26/26
Sequence Identity: 22% (7 aa)

SLEAIYLDN-N--PLNGTAGWELPVD-ISHL
.|. ..|.. |  .| |.    .| . . .|
NLQHLDLSGCNCCNLTGH----IPPSCF-NL
LRR_1 IRAKj_b-1.AA LRR_1 164-186 22 10.062235 3.19 Pfam 1-26 (26) Show / Hide 
Range on Protein: 164-186
Range on HMM: 1-26/26
Sequence Identity: 22% (6 aa)

ALANLSLTN-S--SVVGSIPAF-LGAM
 |  |.| .    ...|.||   . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKj_b-1.AA LRR_1 188-210 44 0.000927 17.5 Pfam 1-26 (26) Show / Hide 
Range on Protein: 188-210
Range on HMM: 1-26/26
Sequence Identity: 44% (12 aa)

HLKVLNLAY-N--RLTGGIPPS-FVSS
.|..|.| . |  .||| |||| | . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKj_b-1.AA LRR_1 237-259 33 1.57128 6.05 Pfam 1-26 (26) Show / Hide 
Range on Protein: 237-259
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

SLVQLWLQV-N--EIAGTIPPG-LGNA
.|  | |.  |   . |.|||. . | 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKj_b-1.AA LRR_1 261-283 44 0.008768 14.04 Pfam 1-26 (26) Show / Hide 
Range on Protein: 261-283
Range on HMM: 1-26/26
Sequence Identity: 44% (12 aa)

ALQDLKLND-N--RLTGPIPAS-LAEL
 || | |.. |  .||| || | .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKj_b-1.AA LRR_1 284-305 25 23.241711 1.9 Pfam 1-26 (26) Show / Hide 
Range on Protein: 284-305
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

PLAILSVDN-N--ELIGVLPA--FKPA
 | .|.... |   | | .|   |   
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRRNT_2 IRAKj_b-1.AA LRRNT_2 324-362 32 5e-09 32.22 Pfam 1-46 (46) Show / Hide 
Range on Protein: 324-362
Range on HMM: 1-46/46
Sequence Identity: 32% (15 aa)

CSHDVETLLEFIGEFGY--P-ASIVSSWKGD----DPCLWTGIVCD
 ..|...||.|  ..    | ..  |||. .    |.| |||. ||
HNDDGQALLAFKSSLNDSDPHHGVLSSWNPSSSDSDCCSWTGVTCD
LRR_1 IRAKj_b-1.AA LRR_1 366-388 29 0.940728 6.84 Pfam 1-26 (26) Show / Hide 
Range on Protein: 366-388
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

RVSVIDLAG-S--QLVGRLSPA-LVNL
.  ..|| |    .|.| ..|  . ||
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKj_b-1.AA LRR_1 390-412 37 0.00694 14.4 Pfam 1-26 (26) Show / Hide 
Range on Protein: 390-412
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

ALTVLRLNG-N--NISGGIPPV-LTSM
 |..| |.| |  |..| |||  . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKj_b-1.AA LRR_1 414-435 37 0.005387 14.79 Pfam 1-26 (26) Show / Hide 
Range on Protein: 414-435
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

SLQQVDLHN-N--NLSGDLPQ--FPES
.||  || . |  ||.|..|   |   
NLQHLDLSGCNCCNLTGHIPPSCF-NL
Kinase IRAKj_b-1.AA IRAK 605-818 33 3.6e-63 216.18 In-house 1-232 (317) Show / Hide 
Range on Protein: 605-818
Range on HMM: 1-232/317
Sequence Identity: 33% (78 aa)

FSEETVLGRGGFGAVYRGQLDDGT-NIAVKRMEASSVVSSKGVSE-FHA---EIAVLSKVRHRHLVALLGYCIDGNEKLLVYEYLPQGALSHHLFEYR-R
|... ..| |||| |||||..  |   |||.  .   .| ... . | .   |. |... || ..|.|.|||... .  |||.|.| |.|   |      
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

MRLKPLEWKRRLAIALDVARGMEYLHGLAYK-SFIHRDLKPSNILLDDDLRAKVADFGLVK---LAPEGKYSVE-----TRLAGTFGYLAPEYAV--TGR
  .|||.| .|. |..  |.| ..|| .  . ..||.| |..|||||... .| .||||.     |.. ....       .. ||  |..||.    .|.
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQ

VTTKADVFSFGVVLLELISGR-RALDESQPEE
 |.| ||.|||.||||...|. ...|.. . .
LTKKTDVYSFGIVLLEVLTGCRAVYDDRPEHY
Kinase IRAKj_b-1.AA TKL 611-887 21 6.2e-62 212.07 In-house 1-364 (364) Show / Hide 
Range on Protein: 611-887
Range on HMM: 1-364/364
Sequence Identity: 21% (84 aa)

LGRGGFGAVYRGQLDD---------GTNIAVKRMEASSV------------------------VSSKGVSEFHAEIAVLSKVRHRHLVALLGYCIDGNE-
.|.|||| ||.|..           |. .|||..   ..                         .|.   ..  || ..|. || ..| ..|||....  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------KLLVYEYLPQGALSHHLFEYRRMRLKPLEWKRRLAIALDVARGMEYLHGLAY-----KSFIHRDLKPSNILLDDDLR-----------
              .|.|| | | | |.|            | .|. .|||.||||.|||         .  ||||||..|||.|....           
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNA

---AKVADFGLVKLAPEGKYSVETR------------------LAGTFGYLAPEY---------AV-------TGRVTTKADVFSFGVVLLELISGRRAL
   .|..|||| .   . . .  |                     ||....|||          .|        .  ..|.||.|||.|| |.....|  
DWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR--

DESQPEENMHLVTWYRR-----ITSSSSKESLLRIIDPVLG-VGDVTGDVFHSVYT---VSELARHCTAREPYQRPDMGHAVSVL
    |.....  ... .     . .  ....|   |.|.   ..       .  ..   ...|. .| . .| .|| .   .. |
----PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHH--K-M-CPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAKj_b-1.AA Pkinase 605-808 27 5e-47 167.36 Pfam 1-209 (293) Show / Hide 
Range on Protein: 605-808
Range on HMM: 1-209/293
Sequence Identity: 27% (61 aa)

FSEETVLGRGGFGAVYRGQLDDGTN-IAVKRMEASSVVSSKGVSEFH-AEIAVLSKVRHRHLVALLGYCIDGNEKLLVYEYLPQG----ALSHHLFEYRR
.  . ..|.|.|| ||...  .     |||... ..  |.| .. .. .||... ...| . | |.... |...  .| ||.. |     |....     
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST---

MRLKPL--EWKRRLAIALDVARGMEYLHGLAYKSFIHRDLKPSNILLDDDLRA----KVADFGLVK-LAPEGKYSVETRLAGTFGYLAPEYAV-TGRVTT
.| ...  ...    ... ..||.||.|     ..|||||||.|||.|..       |..|||| | .  . ..|  | ..|| .|.|||        ..
WRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGP

KADVFSFGVVLLELISGR
|.|..|.|..| |...||
KVDMWSCGCILYEMLCGR
Kinase IRAKj_b-1.AA LRRK 605-813 26 8.1e-46 158.54 In-house 1-285 (351) Show / Hide 
Range on Protein: 605-813
Range on HMM: 1-285/351
Sequence Identity: 26% (77 aa)

FSEETVLGRGGFG-AVYRGQLDD---------------------------GTNIAVKRMEAS-------------------------------SVVSSKG
. .|  .||||||  |||. . .                           ....|.| ..                                 .  ... 
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

VSEFHAEIAVLSKVRHRHLVALLGYCIDGNEKLLVYEYLPQGALSHHLFEYRRMRL---K-PLEWKRRLAIALDVARGMEYLHGLAYKS--FIHRDLKPS
 .||. |....|. .| ..| |.|.||  .   .| ||.|.|.|.|.|........   |  . |  .| |||..|.||||||    ..  .||||||. 
FREFRHEVWIMSHLNHPNIVSLKGFCI--HPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHS---HNPPIIHRDLKSP

NILL---D---------DDLRAKVADFGLVK---LAPEGKYSVETRLAGTFGYLAPEYAVTG---RVTTKADVFSFGVVLLELISGR-RALDE
||||   .         ..  ||.||||.       ..|   |  .. |..|..|||    .     |.|.|..|||..| ||.... .. ||
NILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMG---VAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDE
Kinase IRAKj_b-1.AA S_TKc 605-891 22 7.7e-45 156.21 SMART 1-231 (231) Show / Hide 
Range on Protein: 605-891
Range on HMM: 1-231/231
Sequence Identity: 22% (67 aa)

FSEETVLGRGGFGAVYRGQLDD-GTNIAVKRMEASSVVSSKGVSEFHAEIAVLSKVRHRHLVALLGYCIDGNEKLLVYEYLPQ--GALSHHLFEYRRMRL
.    ..|.|.|| ||...  . |   |.|..             .  ||..|.| .| ..| |.... | ..  .| ||...  | | ... ...| .|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

-KPLEWKRRLAIALDVARGMEYLHGLAYKSFIHRDLKPSNILLDDDLRAKVADFGLVKLAPEGKYSVETRLAGTFGYLAPEYAVTGRVTT-KADVFSFGV
 .|.   .   ..  .....||.|    . .|||||||.|||||.  . |..|||| ..         | . ||  |.|||       .. |.|. |.|.
RFPFPE-HARFYMYQICCALEYCH---SHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGC

VLLELISGRRALDESQPEENMHLVTWYRRITSSSSKESLLRIIDPVLGVGDVTGDVFHSVYTVSELARHCTAREPYQRPDMGHAVS-----VLSPLV
.| |...|.   .        .. . ...|                                . .. |.|  ..| .||    |        . | .
ILYEMLCGYPPFP--------QMQMMFKKIG----------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAKj_b-1.AA MLK 605-808 27 5.9e-44 150.39 In-house 1-233 (291) Show / Hide 
Range on Protein: 605-808
Range on HMM: 1-233/291
Sequence Identity: 27% (65 aa)

FSEETVLGRGGFGAVYRGQLDDGTN-----IAVKRMEASSVVSSKGVSE-----FHAEIAVLSKVRHRH----LVALLGYCID-GNEKLLVYEYLPQGAL
. .....| |.||.|..|.   ...     .|||| .|.    .|....     |  |.  |....|.      ....| |.. ... ..| ||.. | |
IQFHEWIGSGSFGKVWKGRW-RNKDIVAKIVAVKRVRARIF--DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSL

SHHLFEYR----------RMRLKPLEWKRRLAIALDVARGMEYLHGLAYKSFIHRDLKPSNILLDD------DLRAKVADFGLVKLAPEGKYSVETRLAG
.. | . |          . .         . .||..||||.||| .| |  ||||||..|||.|.      .. .|..|||...   . . .  .  ||
YNVLHGARSKWMDANHNQK-NDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAG

TFGYLAPEY---AVTGRVTTKADVFSFGVVLLELISGR
|. . |||    .  .... |.||.|.|||| |.....
TYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTRE
Kinase IRAKj_b-1.AA TK 605-806 17 1.6e-42 139.87 In-house 1-389 (486) Show / Hide 
Range on Protein: 605-806
Range on HMM: 1-389/486
Sequence Identity: 17% (67 aa)

FSEETVLGRGGFG---AVYRGQLDDG--------------------------TNIAVKRMEASSVVSSKGVSE--------------FHAEIAVLS--KV
   . .||.| ||    ||.|.. ..                          |  ||| . . .  |..   .              . .|.....  . 
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHRHLVALLGYCIDGNEK------------LLVYEYLPQGA----LSHHLFEYRRMRLK-----------------------------------------
.| ..| |.|.| .| .|            ..| || | |     | ..| . |. . .                                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------------------------------PLEWKRRLAIALDVARGMEYLHGLAY---KSFIHRDLKPSNILLDDDLR-----------AKVADFG---
                              .|  ...| .....|.|||||| . .   . |.||||   |.|......           .|.||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LVKLAPEGKYSVETRLAGTFG-------------------------YLAPEYAV---------TGRVTTKADVFSFGVVLLELIS
     | .  ..... . ..  || .                         ..|||            .|. ||| ||.||||.. |. .
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFT
Kinase IRAKj_b-1.AA Dicty4 605-804 31 1.6e-41 136.32 In-house 1-210 (277) Show / Hide 
Range on Protein: 605-804
Range on HMM: 1-210/277
Sequence Identity: 31% (68 aa)

FSEETVLGRGGFGAVYRGQLDDGTNIAVKRMEASSV-VSSKGVSEFHAEIAVLSKVRHRHLVALLGYCI----DGNEKLLVYEYLPQGALSHHLFE--YR
   |  .|.|.|| ||.|    |.  ||| . .  . ....  .||..|.. ..| || ... ..|.|.       . . | ||.|.| |   |      
INIEQRIGKGSFGEVYKGTW-RGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSE

RMRLKPLEWKRRLA---IALDVARGMEYLHG--LAYKSFIHRDLKPSNILLDDDLRAKVADFGLVKLAPEGKYSVE--TRLAGTFGYLAPEYAVTGRVTT
    ..|.| ....   .|.|.|||| .||.       .||||||..|.| |...|.||.|||| ..  ...      .  .|| .. |||  .  . . 
QQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV---IIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNE

KADVFSFGVVLLEL
||||.||| || |.
KADVYSFGIVLWEI
Kinase IRAKj_b-1.AA TyrKc 605-887 23 6.4e-41 143.19 SMART 1-280 (280) Show / Hide 
Range on Protein: 605-887
Range on HMM: 1-280/280
Sequence Identity: 23% (73 aa)

FSEETVLGRGGFGAVYRGQLDDGTNIAVKRMEASSVVSSKGVSEFHAEIAVLSKV--RHRHLVALLGYCIDG-------NEKLLVYEYLPQGALSHHLFE
 . . .||.| || ||.|...  .. ||| . ...      . .|. |. ...|.  .| ..|.|.|.|...          ..| || | |.| ..| .
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

YRRMRLKPLEWKRRLAIALDVARGMEYLHGLAYKSFIHRDLKPSNILLDDDLRAKVADFGLVKLAPEG--------KYSV----ETRLAGTFGYLAPEYA
.|.     | .|  | .....|.||||||      .|||||   |.|.......|..|||| .   ..         |..     ..       .|||  
HRPK----LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

VTGRVTTKADVFSFGVVLLELISGRRALDESQPEEN-----MHLVTWYRRITSSSSKESLLRIIDPVLGVGDVTGDVFHSVYTVSELARHCTAREPYQRP
 .|. ||| ||.||||.. |. .     .  || ..     |     .... .    .    .  | .        |  .    . . . | ...| .||
NYGKFTTKSDVWSFGVCMWEIFT-----YGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-P-MSF------VCCPDEMYQ-IMKQCWHEDPEDRP

DMGHAVSVL
 .   .. .
TFSEIHECF
Kinase IRAKj_b-1.AA Pkinase_Tyr 605-806 30 7.9e-41 138.9 Pfam 1-209 (270) Show / Hide 
Range on Protein: 605-806
Range on HMM: 1-209/270
Sequence Identity: 30% (66 aa)

FSEETVLGRGGFGAVYRGQLD-----DGTNIAVKRMEASSVVSSKG--VSEFHAEIAVLSKV-RHRHLVALLGYCIDGNEK---LLVYEYLPQGALSHHL
 .   .||.| || ||.| ..     ...  ||| .      ...     .| .|......  .| ..| |.| |.|  |    ..| || | | | ..|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE--GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

FEYRRMRLKPLEWKRRLAIALDVARGMEYLHGLAYKSFIHRDLKPSNILLDDDLRAKVADFGLVKLA-PEGKY-SVETRLAGTFGYLAPEYAVTGRVTTK
 . | .  .||  |. | .....|.|||||.    | .|||||   |.|..... .|..|||| ..  ... |  . .        .|||   .|. |||
RKHR-EDKQPLTMKDLLQMCWQIAKGMEYLES---KNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTK

ADVFSFGVVLLELIS
 || ||||.. |...
SDVWSFGVLMWEIFT
Kinase IRAKj_b-1.AA TKL-Unique 609-807 29 1.6e-40 140.63 In-house 3-224 (290) Show / Hide 
Range on Protein: 609-807
Range on HMM: 3-224/290
Sequence Identity: 29% (67 aa)

TVLGRGGFGAVYRGQLDDGTNIAVKRMEASSVVSSKGVSEFHAEIAVLSKVR-HRHLVALLGYCI----DGNEKLLVYEYLPQGALSHHLF-----EYRR
 ..|.||.|.||.|    |. .|.|. .  . .|.. . ||. |. ...| . |  .| . |||.    . ..  .| ||.| | |  .|          
NKIGEGGYGQVYKGKW-RGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNN

MRLKPLEWKRRLAIALDVARGMEYLHGLAYKSFIHRDLKPSNILLDDD-----LRAKVADFGLVKLAP---EGKYSVE-----TRLAGTFGYLAPEYAVT
.. ..| ...|. .|.|.|.||.||| .  .  ||||||.||.|.| .     ...|..||||.|..    .....       .   |.| ..|||    
NNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRM

--GRVTTKADVFSFGVVLLELISG
     ..|.||.|||.|| |....
NFCQYSEKSDVYSFGIVLWEIATR
Kinase IRAKj_b-1.AA TK-Unique 605-806 28 4.1e-39 132.54 In-house 1-234 (294) Show / Hide 
Range on Protein: 605-806
Range on HMM: 1-234/294
Sequence Identity: 28% (68 aa)

FSEETVLGRGGFGAVYRGQLDDGT-------NIAVKRMEASSVVSSKGVSEFHAEIAVLSKVR-HRHLVALLGYCIDG-NEKLLVYEYLPQGALSHHLFE
.  . |.|.| || |.||..  ..       ..|||  ....   .|  ..|  ||......  | ..| .||.|..  .  ....||.|.| | |.| .
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDK--QDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRT

YR---------------------RMRLKPLEWKRRLAIALDVARGMEYLHGLAYKSFIHRDLKPSNILLDDDLRAKVADFGLVK-LAPEGKYSVE-TRLA
 |                     ..|. |.  |. . .| ..|.|||||...  | ..||||  .|.|| .|...|..|||. . .  .|.|| . ..  
CRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQR-KKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGR

GTFGYLAPEYAV--TGRV-TTKADVFSFGVVLLELIS
    ..|||.    .|   ||| || ||||.. |. .
IPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFT
Kinase IRAKj_b-1.AA DRK 612-805 34 1.1e-34 114.93 In-house 8-196 (258) Show / Hide 
Range on Protein: 612-805
Range on HMM: 8-196/258
Sequence Identity: 34% (68 aa)

GRGGFGAVYRGQLDDGTNIAVKRMEASSVVSSKGVSEFHAEIAVLSKVRHRHLVALLGYCIDGNEKLLVYEYLPQGALSHHLFEYRRMRLKPLEWKRRLA
|||..| |.||    || .|||.. .  .   . ..||| || .... ||   .  .| |    . . . ||.| | |   | .     .. ..| ... 
GRGNYGEVFRGTW-RGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHD---ESIE-MDWPLMKQ

IALDVARGMEYLHGLAYKSFIHRDLKPSNILLDDDLRAKVADFGLVK--LAPEGKYSVETRLAGTFGYLAPEYAVTGRVTTKADVFSFGVVLLELI
...|.|.|| |||.      ||||||  | | |.  . |||||||       . .    |   || .  |||     | | ||||.||..|| |..
MMFDCAKGMIYLHCCNP-IIIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQHKFAMT-MCGTPCWTAPEVLRNQRYTEKADVYSFAIVLWECV
Kinase IRAKj_b-1.AA UTK 611-807 25 1e-31 105.78 In-house 7-236 (296) Show / Hide 
Range on Protein: 611-807
Range on HMM: 7-236/296
Sequence Identity: 25% (60 aa)

LGRGGFGAVYRGQLDDGT---NIAVKRMEASSVVSSKGVS-----EFHAEIA---VLSKVR-HRHLVALLGYCIDGNEKLLVYEYLPQGALSHHLFEYRR
||.| || |... ... .     ....  . .. ...  .     .|  | .   ...... |.... |.|.| ..   ..|.|| ..| |.. |   |.
LGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSYLRRHRP

MRLKPLEWKR---RLAIALDVARGMEYLHGLAYKSFIHRDLKPSNILLDDD-------LRAKVADFG---LVKLAP---------EGKYSVET-RLAGTF
    . .| .   ||  |.|.||||.|||.   . |.||||   |.|....       . .|.||||   . ....         |  |.  . . . ..
TPPACPHWLTLHQRLCMAWDIARGMQYLHS---CGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPI

GYLAPEYAVTG-RVTTKADVFSFGVVLLELISG
   |||  . . | ||| ||.|||||. |. ..
RWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTW
Kinase IRAKj_b-1.AA TK 862-887 23 0.01624 3.39 In-house 461-486 (486) Show / Hide 
Range on Protein: 862-887
Range on HMM: 461-486/486
Sequence Identity: 23% (6 aa)

VSELARHCTAREPYQRPDMGHAVSVL
. .| . | ...| .||..   .. |
YYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase IRAKj_b-1.AA LRRK 868-889 36 0.280243 0.26 In-house 330-351 (351) Show / Hide 
Range on Protein: 868-889
Range on HMM: 330-351/351
Sequence Identity: 36% (8 aa)

HCTAREPYQRPDMGHAVSVLSP
|| . .| .|| .   |..|| 
HCWQHDPKKRPHFSQIVKRLSQ