Gene IRAKj_d-1 (S.moellendorffii)

IRAKj_d-1

Species: S.moellendorffii
Alias: IRAKj_d-1
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAKj

Sequence

Name Sequence Type Origin Length Description Download
IRAKj_d-1.AA Protein None 933 None Fasta, JSON
IRAKj_d-1.NA RNA None 2802 None Fasta, JSON
IRAKj_d-1.kin_dom Protein Kinase Domain None 203 None Fasta, JSON

Protein domain

Protein domains of IRAKj_d-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LRRNT_2 IRAKj_d-1.AA LRRNT_2 38-77 22 1e-06 24.72 Pfam 1-46 (46) Show / Hide 
Range on Protein: 38-77
Range on HMM: 1-46/46
Sequence Identity: 22% (11 aa)

NPGDLAVLQSFLQGIDQ-KS---VLTNWKNS----DPCGDRWIHIKCT
.. |.. |..| ....   .   || .|..|    |.|   |  . |.
HNDDGQALLAFKSSLNDSDPHHGVLSSWNPSSSDSDCCS--WTGVTCD
LRR_1 IRAKj_d-1.AA LRR_1 104-125 29 0.048375 11.41 Pfam 1-26 (26) Show / Hide 
Range on Protein: 104-125
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

SLDSLQLQQ-N--GFTGSLPS--LSGL
.| .| |.  |   .||..|.  . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKj_d-1.AA LRR_1 127-149 25 1.158 6.52 Pfam 1-26 (26) Show / Hide 
Range on Protein: 127-149
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

SLSRAYFGG-N--SF-DTIPGDFFTGL
.| . ...| |  .. ..|| . | .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKj_d-1.AA LRR_1 151-177 12 12.38513 2.87 Pfam 1-26 (26) Show / Hide 
Range on Protein: 151-177
Range on HMM: 1-26/26
Sequence Identity: 12% (4 aa)

NVMEIFLED-N--HVN-STPGWSLPAD-IQHC
|  .. | . |  ..  .     .| . . ..
NLQHLDLSGCNCCNLTGH-----IPPSCF-NL
LRR_1 IRAKj_d-1.AA LRR_1 179-201 29 0.810215 7.07 Pfam 1-26 (26) Show / Hide 
Range on Protein: 179-201
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

NLQTLSITN-T--TLGGTIPDF-LGTM
|||.|.. . .   | |.||.  .  .
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKj_d-1.AA LRR_1 203-225 33 2.507815 5.33 Pfam 1-26 (26) Show / Hide 
Range on Protein: 203-225
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

SLKNLYLAY-N--TLRGGIPAT-FAGS
.|. |.| . |   | | ||   | . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKj_d-1.AA LRR_1 253-275 37 0.004951 14.92 Pfam 1-26 (26) Show / Hide 
Range on Protein: 253-275
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

SLTTLWLHV-N--QFSGVIPPG-LGNL
.|..| |   |  ...| |||. . ||
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKj_d-1.AA LRR_1 277-299 33 0.075721 10.72 Pfam 1-26 (26) Show / Hide 
Range on Protein: 277-299
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

SLQDLKLND-N--EFVGVVPQS-LTQL
.|| | |.. |   ..| .| | . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRRNT_2 IRAKj_d-1.AA LRRNT_2 339-378 26 0.001231 14.71 Pfam 1-46 (46) Show / Hide 
Range on Protein: 339-378
Range on HMM: 1-46/46
Sequence Identity: 26% (12 aa)

CDPRVTALLDFAGAADAFTS--PCMTTWKGN----DPCSWTGINCV
 .  . |||.|  . . ...  .    |. .    |.|||||. | 
HNDDGQALLAFKSSLNDSDPHHGVLSSWNPSSSDSDCCSWTGVTCD
LRR_1 IRAKj_d-1.AA LRR_1 381-403 25 3.492297 4.82 Pfam 1-26 (26) Show / Hide 
Range on Protein: 381-403
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

TVTTIQLPNC---QLNGSISTA-LANL
. ... | .|   .| |.|.   . ||
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKj_d-1.AA LRR_1 405-427 25 0.108226 10.17 Pfam 1-26 (26) Show / Hide 
Range on Protein: 405-427
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

GLTALDLRN-N--HISGLLPAA-IVQI
 |. |||.. |  ...| .|   . . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKj_d-1.AA LRR_1 429-451 33 0.04869 11.4 Pfam 1-26 (26) Show / Hide 
Range on Protein: 429-451
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

TLRNLNLFR-N--RLSGPLPPF-PSGL
.|. |.| . |  .|.| .||    .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
Kinase IRAKj_d-1.AA IRAK 593-802 34 2.2e-64 220.23 In-house 1-229 (317) Show / Hide 
Range on Protein: 593-802
Range on HMM: 1-229/317
Sequence Identity: 34% (80 aa)

FSENSILGRGGFGVVYKGELDDGT-KIAVK--RMESAVVNNKGLSEFQA---EIQVLTKVRHRHLVALLGYCIHGNEKLLVYEYMPQGTLSQHLFEFAKH
|...  .| ||||.||.|...  |   |||  . .  .  |.   .||.   |..|... || ..|.|.|||. . .  |||.||| |.|   |   .  
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

GY-HHLTWKHRLSIALDVARGIEYLHGLAHK-SFIHRDLKPSNILLDDTLHAKVADFGLVKLA-PEG---KVSV---ET-RLAGTFGYLAPEYAV--TGR
.    |.|  |.||..  |.||..|| .  . ..||.| |..|||||. . .| .||||.    | .   | ..   .| .. ||  |..||.    .|.
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQ

VTTKVDVYSFGVILMELITGR-QALDTSR
 |.|.||||||. |.|..||. ...| ..
LTKKTDVYSFGIVLLEVLTGCRAVYDDRP
Kinase IRAKj_d-1.AA TKL 599-869 21 3.3e-63 216.29 In-house 1-364 (364) Show / Hide 
Range on Protein: 599-869
Range on HMM: 1-364/364
Sequence Identity: 21% (81 aa)

LGRGGFGVVYKGELDD---------GTKIAVKRMESAVVNNKGL-------------------------SEFQAEIQVLTKVRHRHLVALLGYCIHGNE-
.|.||||.||||..           |. .|||.. |  .... .                          ..  || .. . || ..| ..|||. ..  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------KLLVYEYMPQGT-LSQHLFEFAKHGYHHLTWKHRLSIALDVARGIEYLHGLAH-----KSFIHRDLKPSNILLDDTLH----------
              .|.||.| |. |....            | .|...|||.|||..|||         .  ||||||..|||.|. ..          
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPN

----AKVADFGLVKLAPEGKVSVETR------------------LAGTFGYLAPEY---------AV-------TGRVTTKVDVYSFGVILMELITGRQA
    .|..|||| .   . . .  |                     ||....|||          .|        .  ..|.||||||..| |..|... 
ADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRP

LD--TSRSEETMHLPTWFKRMRVNRETFRSSLDP-----VLEVTDEEFESIC--SVAELAGYCTMREPYQRPDMSHAVNVL
 .   ..... .. |     . .. . ..  . |     ..       .. |  |...|.  |   .| .|| ..  .  |
YYDYPYMPMIFQD-P-FEEMFMMVCDKGLRPPIPPIWQNHH-K-M-CPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAKj_d-1.AA S_TKc 593-873 24 3.5e-47 163.97 SMART 1-231 (231) Show / Hide 
Range on Protein: 593-873
Range on HMM: 1-231/231
Sequence Identity: 24% (70 aa)

FSENSILGRGGFGVVYKGELDD-GTKIAVKRMESAVVNNKGLSEFQAEIQVLTKVRHRHLVALLGYCIHGNEKLLVYEYMPQ--GTLSQHLFEFAKHGYH
.    ..|.|.||.|||.   . | . |.|..            .. |||.| | .| ..| |.... . ..  .| ||...  |.| ... .  .||..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

H-LTWKHRLSIALDVARGIEYLHGLAHKSFIHRDLKPSNILLDDTLHAKVADFGLVKLAPEGKVSVETRLAGTFGYLAPEYAVTGRVTT-KVDVYSFGVI
. ..  |  ...  .....||.| . .  .|||||||.|||||.  | |..|||| ..         | . ||  |.|||       .. |.|..|.|.|
FPFPE-HARFYMYQICCALEYCHSH-G--IIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI

LMELITGRQALDTSRSEETMHLPTWFKRMRVNRETFRSSLDPVLEVTDEEFESICSVAELAGYCTMREPYQRPDMSHAVN-----VLAPMV
| |...|.   .        .. . ||...                         .. ..   |  ..| .||    | .      . | .
LYEMLCGYPPFP--------QMQMMFKKIG-----------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAKj_d-1.AA Pkinase 593-795 28 9.9e-47 166.31 Pfam 1-209 (293) Show / Hide 
Range on Protein: 593-795
Range on HMM: 1-209/293
Sequence Identity: 28% (63 aa)

FSENSILGRGGFGVVYKGELDDGTK-IAVKRMESAVVNNKGLSEFQA--EIQVLTKVRHRHLVALLGYCIHGNEKLLVYEYMPQG----TLSQHLFEFAK
.   ...|.|.||.|||.   .  |  |||...    . . . .     |||.. ...| . | |....  ...  .| ||.. |     |. ..     
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST---

HGYHHL--TWKHRLSIALDVARGIEYLHGLAHKSFIHRDLKPSNILLDDTLHA----KVADFGLVK-LAPEGKVSVETRLAGTFGYLAPEYAV-TGRVTT
. .  .  ....  .... ..||.||.|     ..|||||||.|||.|.. |     |..|||| | .  . . |  | ..|| .|.|||        ..
WRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGP

KVDVYSFGVILMELITGR
|||..|.|.|| |...||
KVDMWSCGCILYEMLCGR
Kinase IRAKj_d-1.AA LRRK 593-799 26 1e-46 161.52 In-house 1-284 (351) Show / Hide 
Range on Protein: 593-799
Range on HMM: 1-284/351
Sequence Identity: 26% (78 aa)

FSENSILGRGGFG-VVYKGELDD---------------------------GTKIAVKRMESA---------VVNN-----------------------KG
. ... .|||||| .||.... .                           ....|.| ..             ||                       . 
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

LSEFQAEIQVLTKVRHRHLVALLGYCIHGNEKLLVYEYMPQGTLSQHLFEFAKHGY----HHLTWKHRLSIALDVARGIEYLHGLAHKS--FIHRDLKPS
..||. |. .. . .| ..| |.|.|||     .| ||.|.|.|...|......|      |..|  .| |||..|.|.||||    ..  .||||||. 
FREFRHEVWIMSHLNHPNIVSLKGFCIHPL--CMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHS---HNPPIIHRDLKSP

NILL---D---------DTLHAKVADFGLVK---LAPEGKVSVETRLAGTFGYLAPEYAVTG---RVTTKVDVYSFGVILMELITGR-QALD
||||   .         .. .||.||||.       ..| ..   .. |..|..|||    .     |.|||.||||.|| ||.|.. .. |
NILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAK---GCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFD
Kinase IRAKj_d-1.AA MLK 593-795 27 3.2e-45 154.82 In-house 1-233 (291) Show / Hide 
Range on Protein: 593-795
Range on HMM: 1-233/291
Sequence Identity: 27% (64 aa)

FSENSILGRGGFGVVYKGELDDGTK-----IAVKRMESAVVNNKGLSE-----FQAEIQVLTKVRHRH----LVALLGYCIH-GNEKLLVYEYMPQGTLS
. .  ..| |.||.|.||.   ..      .|||| ..     |. ..     |. |.  | ...|.      ....| |.  ... ..| ||.. | |.
IQFHEWIGSGSFGKVWKGRW-RNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLY

QHLFEFAKHGY---------HHLTWKHRLSIALDVARGIEYLHGLAHKSFIHRDLKPSNILLDD------TLHAKVADFGLVKLAPEGKVSVETRLAGTF
  | .  ....            .  | ...||..|||..||| .| |  ||||||..|||.|.       ...|..|||...   . . .  .  |||.
NVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTY

GYLAPEY---AVTGRVTTKVDVYSFGVILMELITGR
 . |||    .  .... |.||.|.||.| |..|..
AWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTRE
Kinase IRAKj_d-1.AA TKL-Unique 597-796 30 4.9e-40 138.9 In-house 3-226 (290) Show / Hide 
Range on Protein: 597-796
Range on HMM: 3-226/290
Sequence Identity: 30% (68 aa)

SILGRGGFGVVYKGELDDGTKIAVKRME-SAVVNNKGLSEFQAEIQVLTKVR-HRHLVALLGYCI----HGNEKLLVYEYMPQGTLSQHLF-----EFAK
. .|.||.|.||||.   |...|.|. .  . ..|. . ||  |. .. | . |  .| . |||.    . ..  .| ||.| |.|  .|          
NKIGEGGYGQVYKGKW-RGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNN

HGYHHLTWKHRLSIALDVARGIEYLHGLAHKSFIHRDLKPSNILLDDT-----LHAKVADFGLVKLAP---EGKVSVE-----TRLAGTFGYLAPEYAVT
   . |... |...|.|.|.| .||| .  .  ||||||.||.|.|       . .|..||||.|..    .....       .   |.| ..|||    
NNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRM

--GRVTTKVDVYSFGVILMELITGRQ
     ..|.||||||..| |..|. .
NFCQYSEKSDVYSFGIVLWEIATRKI
Kinase IRAKj_d-1.AA TyrKc 593-869 22 3.7e-39 137.31 SMART 1-280 (280) Show / Hide 
Range on Protein: 593-869
Range on HMM: 1-280/280
Sequence Identity: 22% (73 aa)

FSENSILGRGGFGVVYKGELDDGTKIAVKRMESAVVNNKGLSEFQAEIQVLTKV--RHRHLVALLGYCIHG-------NEKLLVYEYMPQGTLSQHLFEF
 . . .||.| ||.||||...  .. ||| . .       . .|  |.....|.  .| ..|.|.|.|...          ..| |||| | | ..| . 
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

AKHGYHHLTWKHRLSIALDVARGIEYLHGLAHKSFIHRDLKPSNILLDDTLHAKVADFGLVKLAPEG--------KVSV----ETRLAGTFGYLAPEYAV
 ..    |..|. ||.....|.| ||||      .|||||   |.|... ...|..|||| .   ..          ..     ..       .|||   
RPK----LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECIN

TGRVTTKVDVYSFGVILMEL---------------ITGRQALDTSRSEETMHLPTW----FKRMRVNRETFRSSLDPVLEVTDEEFESICS--VAELAGY
.|. ||| ||.|||| . |.               .. ....   .. . |  |                               |  .|.  . ..   
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS------------------------F-VCCPDEMYQIMKQ

CTMREPYQRPDMSHAVNVL
| ...| .|| .|  .  .
CWHEDPEDRPTFSEIHECF
Kinase IRAKj_d-1.AA Dicty4 593-794 32 3.9e-39 128.27 In-house 1-213 (277) Show / Hide 
Range on Protein: 593-794
Range on HMM: 1-213/277
Sequence Identity: 32% (70 aa)

FSENSILGRGGFGVVYKGELDDGTKIAVKRMESAVVN--NKGLSEFQAEIQVLTKVRHRHLVALLGYCI----HGNEKLLVYEYMPQGTLSQHLFE--FA
    ...|.|.|| ||||    |.. ||| . .  .|   . |.|| .|.  . | || ... ..|.|.    |  . . | ||||.|.|   |      
INIEQRIGKGSFGEVYKGTW-RGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSE

KHGYHHLTWKHRLS---IALDVARGIEYLHGLAHKSFIHRDLKPSNILLDDTLHAKVADFGLVKLAPEGKVSVE--TRLAGTFGYLAPEYAVTGRVTTKV
.     | |  ...   .|.|.|||. .||.     .||||||..|.| |. . .||.|||| ..  ...      .  .|| .. |||  .  . . |.
QQQSIKLDWPLIKRAMRMAFDAARGMNWLHC-CNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKA

DVYSFGVILMELITG
|||||| .| |. |.
DVYSFGIVLWEILTR
Kinase IRAKj_d-1.AA Pkinase_Tyr 593-796 30 5.9e-38 129.18 Pfam 1-213 (270) Show / Hide 
Range on Protein: 593-796
Range on HMM: 1-213/270
Sequence Identity: 30% (67 aa)

FSENSILGRGGFGVVYKGELD-----DGTKIAVKRMESAVVNNKG--LSEFQAEIQVLTKV-RHRHLVALLGYCIHGNEK---LLVYEYMPQGTLSQHLF
 . .  ||.| ||.||||...     .... ||| .       .   . .| .|......  .| ..| |.| |..  |    ..| |||| | |  .| 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

EFAKHGYHHLTWKHRLSIALDVARGIEYLHGLAHKSFIHRDLKPSNILLDDTLHAKVADFGLVKLA-PEGKV-SVETRLAGTFGYLAPEYAVTGRVTTKV
.   .. ..|| |. |......|.| |||.    | .|||||   |.|.......|..|||| ..  ...    . .        .|||   .|. ||| 
KHR-EDKQPLTMKDLLQMCWQIAKGMEYLE---SKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKS

DVYSFGVILMELIT-GRQ
||.|||| . |..| |.|
DVWSFGVLMWEIFTYGEQ
Kinase IRAKj_d-1.AA TK 593-793 17 6.3e-38 124.19 In-house 1-389 (486) Show / Hide 
Range on Protein: 593-793
Range on HMM: 1-389/486
Sequence Identity: 17% (70 aa)

FSENSILGRGGFG---VVYKGELDDG--------------------------TKIAVKRMES-AVVNNKGLSE--------------FQAEIQVLT--KV
      ||.| ||   .|||||. ..                          |. ||| . . .  . .   .              . .|....   . 
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHRHLVALLGYCIHGNEK------------LLVYEYMPQGT----LSQHLFEFAKHGYH-----------------------------------------
.| ..| |.|.| .| .|            ..| |||| |     | ..| .  ... |                                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------------------------------HLTWKHRLSIALDVARGIEYLHGLAH---KSFIHRDLKPSNILLDDTLH-----------AKVADFG---
                              .|| ...| .....|.| |||| .     . |.||||   |.|... ..           .|.||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LVKLAPEGKVSVETRLAGTFG-------------------------YLAPEYAV---------TGRVTTKVDVYSFGVILMELIT
     | .  ....  . ..  || .                         ..|||            .|. ||| ||.|||| . |. |
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFT
Kinase IRAKj_d-1.AA DRK 600-793 34 2.4e-33 110.32 In-house 8-197 (258) Show / Hide 
Range on Protein: 600-793
Range on HMM: 8-197/258
Sequence Identity: 34% (68 aa)

GRGGFGVVYKGELDDGTKIAVKRMESAVVN-NKGLSEFQAEIQVLTKVRHRHLVALLGYCIHGNEKLLVYEYMPQGTLSQHLFEFAKHGYHHLTWKHRLS
|||..| |. |    ||..|||..    .|  . |.||. || .. . ||   .  .| |    . . . |||| | | . | . .      . |  ...
GRGNYGEVFRGTW-RGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDES----IEMDWPLMKQ

IALDVARGIEYLHGLAHKSFIHRDLKPSNILLDDTLHAKVADFGLVK--LAPEGKVSVETRLAGTFGYLAPEYAVTGRVTTKVDVYSFGVILMELIT
...|.|.|. |||.      ||||||  | | |.    |||||||       . .    |   || .  |||     | | | |||||...| |..|
MMFDCAKGMIYLHC-CNPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQHKFAMT-MCGTPCWTAPEVLRNQRYTEKADVYSFAIVLWECVT
Kinase IRAKj_d-1.AA RIPK 599-797 28 2.5e-33 110.9 In-house 1-227 (290) Show / Hide 
Range on Protein: 599-797
Range on HMM: 1-227/290
Sequence Identity: 28% (66 aa)

LGRGGFGVVYKGE-LDDGTKIAVKRMESAVVN----NKGLSEFQAEIQVLTKVRHRHLVALLGYCIHG----NEKL--LVYEYMPQGTLSQHLFEFAKHG
.|.|||| |.|    . |. .|.|   .  .      .   .   | . . | |..| | ..| |.      . ||  .| |||. | |.  |    .. 
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ

YHHLTWKHRLSIALDVARGIEYLHGLAHKS--FIHRDLKPSNILLDDTLHAKVADFGLVKLAPEGKVSVETR-----------LA-GTFGYLAPEYAV--
 | . |. |  .   ...|  |||.   .    |||||||.|||.|  .|.|.||||| .     ..  . .           .  ||  |..||  .  
HHPDPWPLRCRMIHEISCGMCYLHS---MNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTD

-TGR---VTTKVDVYSFGVILMELITGRQA
   .   ||.| |||||.... |. |....
NKKPIKVVTPKYDVYSFAIVMWEVLTQKHP
Kinase IRAKj_d-1.AA STE 593-795 22 1.5e-32 112.3 In-house 1-265 (359) Show / Hide 
Range on Protein: 593-795
Range on HMM: 1-265/359
Sequence Identity: 22% (61 aa)

FSENSILGRGGFGVVYKGELDD----------------GTKIAVKRME---------------SAVVNNKGLSEFQAEIQVLTKVR--HRHLVALLGYCI
.   ...|.|.||.|||.   .                |. .|.|.|.                  .|.. . ... ||... | .  | . |  .|...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

HG-------NEKLLVYEYMPQGTLS---QHLFEFAK-------HGYHHLTWKHRLSIALDVARG-IEYLHGLAHKSFIHRDLKPSNILLDDTLHAKVADF
..       .|  .. |||. |.|.   .| ..  |       |  |..  .    |. .. .|  .||| .     ||||.||.||||     .| .||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQH-QHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDF

GLVK-LAPEGK--------------VSVETRLAGTFGYLAPEYAVTGR------VTTKVDVYSFGVILMELITGR
|. . |....               ..  . ..||  . |||    ..       .||.|..|.|  ..|..||.
GVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK
Kinase IRAKj_d-1.AA TK 851-869 31 0.0522 1.66 In-house 468-486 (486) Show / Hide 
Range on Protein: 851-869
Range on HMM: 468-486/486
Sequence Identity: 31% (6 aa)

CTMREPYQRPDMSHAVNVL
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CWHYDPEDRPTFSQLHEQL