Gene IRAKk_g (S.moellendorffii)
IRAKk_g
Species: S.moellendorffii
Alias: IRAKk_g
External Links:
Annotation:
Sequence
Name | Sequence Type | Origin | Length | Description | Download |
---|---|---|---|---|---|
IRAKk_g.AA | Protein | None | 314 | None | Fasta, JSON |
IRAKk_g.NA | RNA | None | 945 | None | Fasta, JSON |
IRAKk_g.kin_dom | Protein Kinase Domain | None | 199 | None | Fasta, JSON |
Protein domains of IRAKk_g.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | IRAKk_g.AA | IRAK | 14-214 | 36 | 4.1e-79 | 269.15 | In-house | 1-225 (317) | Show / Hide |
Range on Protein: 14-214 Range on HMM: 1-225/317 Sequence Identity: 36% (81 aa) FSEENLIGEGGFARVYKAQLDDDH-AIAVKKLSTEND----QADEEFRA---EINLMGRIHHPNLIALLGFSSQGEDRLLIYELMTNGSLQDQLQGPAQG |...|.||||||. ||..|.. ||||| ..| . ...|.. |. .. |..|||. .|.|....... |.|..|.||||.|.|.. .. FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ AA---LTWHLRLKIALDAARGLEYLHDHC-DPPVIHRDFKSSNILLDEDFNAKLSDFGLALMV----QEGAGSL------QLQGTFGYVAPEYIL--TGI . |.|| |..|.. .|.|...||. |.||.| ||.|||||..|..|..||||. .... ..|| | .||.| .|. CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQ LTEKSDVYAFGVVLLELITGRKPID || |.||| ||.||||..||... . LTKKTDVYSFGIVLLEVLTGCRAVY |
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Kinase | IRAKk_g.AA | TKL | 20-212 | 24 | 1.4e-68 | 234.13 | In-house | 1-288 (364) | Show / Hide |
Range on Protein: 20-212 Range on HMM: 1-288/364 Sequence Identity: 24% (74 aa) IGEGGFARVYKAQLDD---------DHAIAVKKLSTENDQAD---------------------------EEFRAEINLMGRIHHPNLIALLGFSSQGED- ||.|||. |||... . .||||....||. . .... ||..| |..|||.. ..|.. .... IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG ------------RLLIYELMTNGSLQDQLQGPAQGAALTWHLRLKIALDAARGLEYLHDHCD-----PPVIHRDFKSSNILLDEDFN------------- ...|.. .||| ..|. ||.|...|||.|||..||| . ||.|||| ||.|||.||... CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW -AKLSDFGLALMVQEGAG--------------------SLQLQGTFGYVAPEYIL----------------TGILTEKSDVYAFGVVLLELITGRKP .|..||||. .... . . ||... ||| . . .||.|||.||.|| |..|...| CCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRP |
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Kinase | IRAKk_g.AA | LRRK | 14-214 | 27 | 4.1e-55 | 189.4 | In-house | 1-284 (351) | Show / Hide |
Range on Protein: 14-214 Range on HMM: 1-284/351 Sequence Identity: 27% (79 aa) FSEENLIGEGGFA-RVYKAQLDD---------------------------DHAIAVKKLSTE-----NDQAD---------------------------- . .|..||.|||. .||.| . . . .|.||. .. || . LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDND-CNNSNNNNNLNNNNSEQVEDMDQNHEDCCR --EEFRAEINLMGRIHHPNLIALLGFSSQGEDRLLIYELMTNGSLQDQLQGPAQGA------ALTWHLRLKIALDAARGLEYLHDHCDPPVIHRDFKSSN ||| |. .| . .|||.. |.||. . . .. |....|.|.. |. ..| . ..|.|.|||||. |.|.||||.| .||.|||| || | AFREFRHEVWIMSHLNHPNIVSLKGFCI--HPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSH-NPPIIHRDLKSPN ILL---D---------EDFNAKLSDFGLAL--MVQEGAGSLQLQGTFGYVAPEYILTG---ILTEKSDVYAFGVVLLELITGR-KPID ||| . .. .||..|||. . .. . |..|..||| . . |||.|.|.||..| ||.|.. | | ILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFD |
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Kinase | IRAKk_g.AA | MLK | 14-212 | 27 | 3.3e-45 | 154.76 | In-house | 1-235 (291) | Show / Hide |
Range on Protein: 14-212 Range on HMM: 1-235/291 Sequence Identity: 27% (66 aa) FSEENLIGEGGFARVYKAQLDDDH----AIAVKKLS--TENDQAD-----EEFRAEINLMGRIHHPN----LIALLGFSSQ-GEDRLLIYELMTNGSLQD . .. ||.|.| |.|.. .|||. .. | .| ..|. |... .. ||| |...| ..| . . ... | . .||| . IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN QLQG-PAQGA----------ALTWHLRLKIALDAARGLEYLHDHCDPPVIHRDFKSSNILLDE------DFNAKLSDFGLALMVQEG-AGSLQLQGTFGY | | . ... . .. ...||. |||..||| . .|.|||| ||.|||.|| . ..| .|||.. .... . .||. . VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAW VAPEYI---LTGILTEKSDVYAFGVVLLELITGRKP ||| | . .||.||. .|||| |..|.. | MAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVP |
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Kinase | IRAKk_g.AA | Pkinase | 14-210 | 26 | 4.2e-45 | 160.56 | Pfam | 1-209 (293) | Show / Hide |
Range on Protein: 14-210 Range on HMM: 1-209/293 Sequence Identity: 26% (57 aa) FSEENLIGEGGFARVYKAQLDDDHA-IAVKKLSTENDQADEEFRA-----EINLMGRIHHPNLIALLGFSSQGEDRLLIYELMTNG----SLQDQLQGPA . . ||.|.|..|||.. .. |||... . .. ... .. || .| |..||| . |... . . .. |.. .| .| | ... YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST-W QGAAL--TWHLRLKIALDAARGLEYLHDHCDPPVIHRDFKSSNILLDEDFNA----KLSDFGLALM--VQEGAGSLQLQGTFGYVAPEYIL-TGILTEKS .. .. ... .... .|||||.|.. .|||| |..|||.|.. . |..||||| . . || .|.||| |. . |. RHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV DVYAFGVVLLELITGR |....|..| |...|| DMWSCGCILYEMLCGR |
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Kinase | IRAKk_g.AA | TKL-Unique | 18-209 | 33 | 8.2e-45 | 155.19 | In-house | 3-224 (290) | Show / Hide |
Range on Protein: 18-209 Range on HMM: 3-224/290 Sequence Identity: 33% (75 aa) NLIGEGGFARVYKAQL-DDDHAIAVKK-LSTENDQADEEFRAEINLMGRIH-HPNLIALLGFSS----QGEDRLLIYELMTNGSLQDQLQ-------GPA |.|||||...|||. .. || ... .. . . .||. |.|.| ..| |||. . |.. . .. .. | . ||| | |. . NKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNN QGAALTWHLRLKIALDAARGLEYLHDHCDPPVIHRDFKSSNILLDED-----FNAKLSDFGLALMVQEG-AGSLQ---------LQGTFGYVAPEYILTG . |.. .|.|.|.|.|.|..||| ||.||.|||| ||||.|.|.. .|.|..||||. .... .|.| ..||| .|.. NNCKLNMQQRVKMAIDIAQGMYYLH-HCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPE-VLRM ---ILTEKSDVYAFGVVLLELITG .||||||.||.|| |..|. NFCQYSEKSDVYSFGIVLWEIATR |
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Kinase | IRAKk_g.AA | Dicty4 | 14-212 | 34 | 6.3e-43 | 141.1 | In-house | 1-216 (277) | Show / Hide |
Range on Protein: 14-212 Range on HMM: 1-216/277 Sequence Identity: 34% (76 aa) FSEENLIGEGGFARVYKAQLDDDHAIAVKKLSTENDQADE----EFRAEINLMGRIHHPNLIALLGFSS----QGEDRLLIYELMTNGSLQDQLQG---- |..||.|.|. |||. . ||||| |. .|| |||.|...|. | |||.. ..| . . .. . |.| |.| | INIEQRIGKGSFGEVYKGTW-RGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSE PAQGAALTWHLRLK---IALDAARGLEYLHDHCDPPVIHRDFKSSNILLDEDFNAKLSDFGLALMVQEGAGSLQ----LQGTFGYVAPEYILTGILTEKS | | | |... .|.|||||. .|| |.| .|||| ||.|.| |.....| .||||. . ... . || ...||| .||. QQQSIKLDWPLIKRAMRMAFDAARGMNWLHC-CNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKA DVYAFGVVLLELITGRKP ||| || || |. |. | DVYSFGIVLWEILTRQEP |
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Kinase | IRAKk_g.AA | TK | 14-212 | 17 | 5.1e-42 | 138.17 | In-house | 1-394 (486) | Show / Hide |
Range on Protein: 14-212 Range on HMM: 1-394/486 Sequence Identity: 17% (69 aa) FSEENLIGEGGFA---RVYKAQLDDD--------------------------HAIAVKKLSTENDQADEEFRA-----------------EINLMG--RI .. .||| | .|||... .. . ||| | ......|||.. |. .| ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG HHPNLIALLGFSSQGED------------RLLIYELMTNGS----LQDQLQGPAQGAA------------------------------------------ ||||.. |.| ..||| ... |.| .|. |.| |. .. HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY -------------------------------LTWHLRLKIALDAARGLEYLHDH----CDPPVIHRDFKSSNILLDEDFN-----------AKLSDFGLA || | .| .....|.|.||||.. . ..||| |.|..|. . .|..||||. DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS ------LMVQEGAGSLQLQGTFGY-----------------------------VAPEYIL---------TGILTEKSDVYAFGVVLLELIT-GRKP | . .. . .. ||| .. .|. |.||||..|||.. |. | |..| RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEP |
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Kinase | IRAKk_g.AA | RIPK | 20-212 | 28 | 1.6e-38 | 128.86 | In-house | 1-227 (290) | Show / Hide |
Range on Protein: 20-212 Range on HMM: 1-227/290 Sequence Identity: 28% (66 aa) IGEGGFARVYKAQLDDDHAIAVKKLST-EN------DQADEEFRAEINLMGRIHHPNLIALLGFSSQGED------RLLIYELMTNGSLQDQLQGPA--Q .| ||| |.||. . ..|| .. . || .. | | .. . . ..|| . |. . | | |||| . |. | VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ GAALTWHLRLKIALDAARGLEYLHDHCDPPVIHRDFKSSNILLDEDFNAKLSDFGLALMVQEGAGSLQLQ-----------------GTFGYVAPEYIL- . | || . ..| |||. .||.|||| | .|||.| .|..|..||||| . .| . | || | .|| .. HHPDPWPLRCRMIHEISCGMCYLHSM-NPPIIHRDLKPENILVDNNFHVKIADFGLATWMM---WSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRT -----TGILTEKSDVYAFGVVLLELITGRKP . . |.|.||| |..|. |. |...| DNKKPIKVVTPKYDVYSFAIVMWEVLTQKHP |
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Kinase | IRAKk_g.AA | Pkinase_Tyr | 14-161 | 31 | 3.5e-38 | 129.94 | Pfam | 1-158 (270) | Show / Hide |
Range on Protein: 14-161 Range on HMM: 1-158/270 Sequence Identity: 31% (51 aa) FSEENLIGEGGFARVYKAQLD-----DDHAIAVKKLSTENDQAD---EEFRAEINLMGRI-HHPNLIALLGFSS-QGED--RLLIYELMTNGSLQDQLQG . .||| | .|||. .. .. |||.| .. . |.| .|...| . ||||.. |.| . ||| ... |.| .|.| | |. ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK P-AQGAALTWHLRLKIALDAARGLEYLHDHCDPPVIHRDFKSSNILLDEDFNAKLSDFGLA . .. .|| . |..... |.|.|||... |||| |.|..|.. .| .||||| HREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLA |
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Kinase | IRAKk_g.AA | DRK | 39-208 | 36 | 8.9e-37 | 122.1 | In-house | 25-197 (258) | Show / Hide |
Range on Protein: 39-208 Range on HMM: 25-197/258 Sequence Identity: 36% (65 aa) IAVKKLSTENDQ-AD--EEFRAEINLMGRIHHPNLIALLGFSSQGEDRLLIYELMTNGSLQDQLQGPAQGAALTWHLRLKIALDAARGLEYLHDHCDPPV .|||.| | . ||. ||||| . ||| . .| | . . | | ||| | .. . | |......|.|.|. ||| |.| . VAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDES--IEMDWPLMKQMMFDCAKGMIYLH-CCNPII IHRDFKSSNILLDEDFNAKLSDFGLAL----MVQEGAGSLQLQGTFGYVAPEYILTGILTEKSDVYAFGVVLLELIT |||| || | | || . | .||||. . | .. || . .||| ||| ||| |..|| |..| IHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQHKFAMTMC-GTPCWTAPEVLRNQRYTEKADVYSFAIVLWECVT |
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Kinase | IRAKk_g.AA | TK-Unique | 14-208 | 25 | 5.5e-36 | 121.61 | In-house | 1-234 (294) | Show / Hide |
Range on Protein: 14-208 Range on HMM: 1-234/294 Sequence Identity: 25% (61 aa) FSEENLIGEGGFARVYKAQLDD-------DHAIAVKKLS-TENDQADEEFRAEINLMGRIH-HPNLIALLGFSSQG-EDRLLIYELMTNGSLQDQLQGPA . ...|||| | |..... .. .|||.| ..|. . .| ||..| . |||.. .|| . |. ..|.| . .|.||. |. . LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR QG-----------------------AALTWHLRLKIALDAARGLEYLHD--H-CDPPVIHRDFKSSNILLDEDFNAKLSDFGLA--------LMVQEGAG .. .... .. . .| . |.|.|||. . . .||| ..|.|| ||...|..|||.| .. ... | PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKI----VHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQG SLQLQGTFGYVAPEYIL--TGIL-TEKSDVYAFGVVLLELIT ... . |||... .|. |.||||..|||.. |. | RIPIR----WMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFT |
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Kinase | IRAKk_g.AA | TyrKc | 14-283 | 24 | 5e-34 | 120.28 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 14-283 Range on HMM: 1-280/280 Sequence Identity: 24% (74 aa) FSEENLIGEGGFARVYKAQLDDDHAIAVKKLSTENDQADEEFRAEINLMGRI--HHPNLIALLGFSSQG-------EDRLLIYELMTNGSLQDQLQGPAQ . . .||| | .|||.... |||.| . |.|. |...| .. ||||...|.| .|. | ... |.| .|.|.| |. . ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP GAALTWHLRLKIALDAARGLEYLHDHCDPPVIHRDFKSSNILLDEDFNAKLSDFGLALMVQEG--------AGSL----QLQ--GTFGYVAPEYILTGIL |.. |......|.| ||||.. ..|||| |.|..|.. .| |||||. . .. . . ||| | .|. K--LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF TEKSDVYAFGVVLLELIT-GRKPIDV---SMPTGCQSLVTWATPQLTDRTRLPLIVD--------AAIKDTVNLKQLFQVAAVAVLCVQSEPSYRPLIGD |.||||..|||.. |. | | .| . | .. . . .. |.| . . . . . | . .|. || . TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEY----VKQGYRMPQPPNDYPMSFVCCPDE----------MYQIMKQCWHEDPEDRPTFSE VVNSL .. . IHECF |
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Kinase | IRAKk_g.AA | S_TKc | 14-287 | 22 | 4e-33 | 117.29 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 14-287 Range on HMM: 1-231/231 Sequence Identity: 22% (65 aa) FSEENLIGEGGFARVYKAQLDD-DHAIAVKKLSTENDQADEEFRAEINLMGRIHHPNLIALLGFSSQGEDRLLIYELMTN--GSLQDQLQGPAQGAA--- . ..||.|.|..|||.. . .. |.|... | .| ||... . ||||.. |... .. .. |.. . |.| | .. . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP LTWHLRLKIALDAARGLEYLHDHCDPPVIHRDFKSSNILLDEDFNAKLSDFGLALMVQEGAGSLQLQGTFGYVAPEYILTGILTEKSDVYAFGVVLLELI .. ... ...|||.|.| .|||| | .|||||| . |..||||| . . || |.||| . | ..|.|....|..| |.. FPE-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCILYEML TGRKPIDVSMPTGCQSLVTWATPQLTDRTRLPLIVDAAIKDTVNLKQLFQVAAVAVLCVQSEPSYRPLIGDVVN-----SLIPLV .|. | . | . . .. .. | | .|. || . .. . . | . CGYPPFP-QMQMMFKKIG-----------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | IRAKk_g.AA | Pkinase_Tyr | 181-212 | 51 | 1.2e-07 | 26.58 | Pfam | 182-214 (270) | Show / Hide |
Range on Protein: 181-212 Range on HMM: 182-214/270 Sequence Identity: 51% (17 aa) APEYILTGILTEKSDVYAFGVVLLELIT-GRKP ||| | .|. |.||||..|||.. |..| |..| APECINYGKFTTKSDVWSFGVLMWEIFTYGEQP |
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Kinase | IRAKk_g.AA | TK-Unique | 265-283 | 36 | 0.02894 | 3.76 | In-house | 276-294 (294) | Show / Hide |
Range on Protein: 265-283 Range on HMM: 276-294/294 Sequence Identity: 36% (7 aa) CVQSEPSYRPLIGDVVNSL | |.||. || . .... | CWQWEPEERPSFRQIKHRL |