Gene IRAKk_e-2 (S.moellendorffii)

IRAKk_e-2

Species: S.moellendorffii
Alias: IRAKk_e-2
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAKk

Sequence

Name Sequence Type Origin Length Description Download
IRAKk_e-2.AA Protein None 597 None Fasta, JSON
IRAKk_e-2.NA RNA None 1794 None Fasta, JSON
IRAKk_e-2.kin_dom Protein Kinase Domain None 205 None Fasta, JSON

Protein domain

Protein domains of IRAKk_e-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IRAKk_e-2.AA IRAK 233-439 36 3.8e-66 226.06 In-house 1-225 (317) Show / Hide 
Range on Protein: 233-439
Range on HMM: 1-225/317
Sequence Identity: 36% (84 aa)

FDPANLLGEGGFGRVYRGNLKDGM-AVAIKRLSSGGH----QGDKEFLV---EVEMLSRLHHRHLVKLVGFFSSRDSSQHLLCYELVPNGSLESWLHGRL
|...|..|||||| |||| .|     .|.|.| ..      . ...|.    |.. ..|..| ..| | |... |.  .| | |.. ||||||  |... 
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQ--CHCLVYPYMPNGSLEDRLWCQD

GANNP--LDWDTRMKIAIGAARGLAYLHEDCQPC--VIHRDFKASNILLEDNFQAKVADFGLAKQA-PEG---QTSY---VSTRVMGTFGYVAPEYAM--
|.. |  | | .| .|..|.|.|. .||.. .||  .||.| | .|||| ..|..| .||||.    | .   ...|      .| ||  | .||.    
GQCPPKPLSWHQRCSICWGTACGIQFLHQN-HPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDP

TGHLLVKSDVYSYGVVLLELLSGRKPVD
.| | .|.|||| |.||||.|.|...|.
QGQLTKKTDVYSFGIVLLEVLTGCRAVY
Kinase IRAKk_e-2.AA TKL 239-508 20 3.1e-65 223.06 In-house 1-364 (364) Show / Hide 
Range on Protein: 239-508
Range on HMM: 1-364/364
Sequence Identity: 20% (78 aa)

LGEGGFGRVYRGNLKD---------GMAVAIKRLSSGGHQGD---------------------------KEFLVEVEMLSRLHHRHLVKLVGFFSSRD--
.|.|||| ||.|...          |  ||.|...|   . .                           ... .|. |.|||.| ..|...|.  . .  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

---------SSQHLLCYELVPNGSLESWLHGRLGANNPLDWDTRMKIAIGAARGLAYLHE-DC----QPCVIHRDFKASNILLEDNFQ------------
         ..|. . .|..|.|||.. ||          |. |...|...|||..|||  .      | .|||| | .|||. .|..            
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD

--AKVADFGLAK-QAPEGQTSYVSTR----------------VMGTFGYVAPEYAM----------------TGHLLVKSDVYSYGVVLLELLSGRKPVD
  .|..||||..   ..|. .  .|                 . ||... |||  .                 .    |.||||.|.|| |.|....   
WCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR---

MAQPTGQENLVTWA------RPVLKDVDRIYELADP-------RLNGQYPREDFAQVAAVAAACVAPEANQRPTMGEVVQSL
   |  ...  ..           ...|. . .  |       .   . .     ...  .  | ......||.. |... |
---PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHK-M-CPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAKk_e-2.AA Dicty4 233-432 32 1.5e-39 129.69 In-house 1-211 (277) Show / Hide 
Range on Protein: 233-432
Range on HMM: 1-211/277
Sequence Identity: 32% (70 aa)

FDPANLLGEGGFGRVYRGNLKDGMAVAIKRLSSGGHQGD------KEFLVEVEMLSRLHHRHLVKLVGFFSSR----DSSQHLLCYELVPNGSLESWLHG
 .  ...|.|.|| ||.|. . | .||.| | .  |. .      .||. ||. .. . | ..... |  ..      ..  . . |..| |.|.| || 
INIEQRIGKGSFGEVYKGTWR-GKEVAVKKLNN--HNQNFDENMLNEFRKEVHIMCKIRHPNICLFMG--ACTAPRSHPGKMCIVTEYMPKGNLYSLLHD

---RLGANNPLDWDTRMK---IAIGAARGLAYLHEDCQPCVIHRDFKASNILLEDNFQAKVADFGLAK--QAPEGQTSYVSTRVMGTFGYVAPEYAMTGH
       . .||| .. .   .|. ||||...||. | | .|||| |..|.|  .|...||.||||..  .  | ..   .| . || ...|||  |   
KPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHC-CNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMT-ACGTPCWMAPEVMMHQP

LLVKSDVYSYGVVLLELL
   |.||||.| || |.|
YNEKADVYSFGIVLWEIL
Kinase IRAKk_e-2.AA TK 233-437 16 1.6e-39 129.64 In-house 1-394 (486) Show / Hide 
Range on Protein: 233-437
Range on HMM: 1-394/486
Sequence Identity: 16% (64 aa)

FDPANLLGEGGFG---RVYRGNLKDG--------------------------MAVAIKRLSSGGHQGDKE-----------------FLVEVEMLS--RL
    . |||| ||   .||.| ....                          . ||.| | .| .. ..|                 .. | .|..   .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

HHRHLVKLVGFFSSRDS----------SQHLLCYELVPNGS----LESWLHGRLGANNP-----------------------------------------
|| ..|.|.|  .  ..             ..  |..|.|.    | ..|. . .  ..                                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LDWDTRMKIAIGAARGLAYLHED----CQPCVIHRDFKASNILLEDNFQ-----------AKVADFGLA
                               |.  ... ..  .|.|..|||.       . ..|||  | |.|. .| .           .|.|||||.
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

K-----QAPEGQT--SYVSTRVMGTFG-------------------------YVAPEYAM---------TGHLLVKSDVYSYGVVLLELLS-GRKP
.      | . .    |....  || .                         . |||  .         .|.   ||||.|.||.. |... |..|
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEP
Kinase IRAKk_e-2.AA S_TKc 233-511 22 1.1e-37 132.4 SMART 1-231 (231) Show / Hide 
Range on Protein: 233-511
Range on HMM: 1-231/231
Sequence Identity: 22% (66 aa)

FDPANLLGEGGFGRVYRGNLKD-GMAVAIKRLSSGGHQGDKEFLVEVEMLSRLHHRHLVKLVGFFSSRDSSQHLLCYELVPN--GSLESWLHGRLGANNP
..  ...|.|.||.||..  |. |  ||||...       . .. |...|.. || ..||| ..| .   .   .. |....  |.| . .. | .  ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--LDWDTRMKIAIGAARGLAYLHEDCQPCVIHRDFKASNILLEDNFQAKVADFGLAKQAPEGQTSYVSTRVMGTFGYVAPEYAMTGHLLVKSDVYSYGVV
  ..  .  ...   ...|.|.|.  .  .|||| | .|||| .  . |..|||||.|          | . ||  |.|||    |.   |.|..| |..
FPFPE-HARFYMYQICCALEYCHS--H-GIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCI

LLELLSGRKPVDMAQPTGQENLVTWARPVLKDVDRIYELADPRLNGQYPREDFAQVAAVAAACVAPEANQRPTMGEVVQ------SLKMV
| |.|.|. | .        .. .  . ..                        ..      |   . ..|||  |. |      .   .
LYEMLCGYPPFP--------QMQMMFKKIG----------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAKk_e-2.AA TKL-Unique 235-434 31 4.7e-36 124.68 In-house 1-224 (290) Show / Hide 
Range on Protein: 235-434
Range on HMM: 1-224/290
Sequence Identity: 31% (72 aa)

PANLLGEGGFGRVYRGNLKDGMAVAIKRLS--SGGH-QGDKEFLVEVEMLSRLH-HRHLVKLVGFFS--SRDSSQHLLCYELVPNGSLESWLH------G
. |..||||.|.||.|  . |  ||||...  .. . .  .||  ||  ...|| |  .|...|.      . ..  .  | .| ||| . ||       
FWNKIGEGGYGQVYKGKWR-GYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

RLGANNPLDWDTRMKIAIGAARGLAYLHEDCQPCVIHRDFKASNILLEDN-----FQAKVADFGLAKQAPEGQTSYVS-------TRVMGTFGYVAPEYA
    |..|..  |.|.|| .|.|. |||    | .|||| | ||.|.  |     ...|..||||.| .    .. ..       . ..|.| ..|||  
NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVL

MT--GHLLVKSDVYSYGVVLLELLSG
.    .   ||||||.|.|| |....
RMNFCQYSEKSDVYSFGIVLWEIATR
Kinase IRAKk_e-2.AA Pkinase_Tyr 239-437 30 5.4e-36 122.53 Pfam 7-214 (270) Show / Hide 
Range on Protein: 239-437
Range on HMM: 7-214/270
Sequence Identity: 30% (64 aa)

LGEGGFGRVYRGNLK-----DGMAVAIKRLSSGGHQGD---KEFLVEVEMLSRL-HHRHLVKLVGFFSSRDSS-QHLLCYELVPNGSLESWLHG-RLGAN
|||| ||.||.| .|     ... ||.| |  | .. .   ..|. |..... | || ..|.|.|  .... . |...  |..|.|.| . |.  |   .
LGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHR-EDK

NPLDWDTRMKIAIGAARGLAYLHEDCQPCVIHRDFKASNILLEDNFQAKVADFGLAKQAPEGQTS-YVSTRVMGTFGYVAPEYAMTGHLLVKSDVYSYGV
.||.  .  ....  |.|..||..      ||||  | |.|...|...|..|||||.   .  .  ....  .      |||  ..|   .||||.|.||
QPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGV

VLLELLS-GRKP
.. |... |..|
LMWEIFTYGEQP
Kinase IRAKk_e-2.AA LRRK 233-439 24 5.9e-35 121.1 In-house 1-284 (351) Show / Hide 
Range on Protein: 233-439
Range on HMM: 1-284/351
Sequence Identity: 24% (73 aa)

FDPANLLGEGGFG-RVYRGNLKD---------------------------GMAVAIKRLSSGG----------------------------------HQG
.   ...|.|||| .|||.....                           .  |||| .  ..                                  .  
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

DKEFLVEVEMLSRLHHRHLVKLVGFFSSRDSSQHL-LCYELVPNGSLESWLHGRLGAN-----NPLDWDTRMKIAIGAARGLAYLHEDCQPCVIHRDFKA
  ||  || ..|.|.| ..|.|.||     . ..| .  |..|.|.| . || .           ..| .. |||.  |.|..||| .. | .|||| | 
FREFRHEVWIMSHLNHPNIVSLKGF-----CIHPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLH-SHNPPIIHRDLKS

SNILL-ED-----------NFQAKVADFGLAK--QAPEGQTSY-VSTRVMGTFGYVAPEYAMTG---HLLVKSDVYSYGVVLLELLSGR-KPVD
 |||| .            .  ||.||||.    |.    . . |  .. |..|..|||    .       |.|.||.|..| |||...  | |
PNILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQC----FHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFD
Kinase IRAKk_e-2.AA Dicty4-Unclassified 236-437 31 2.2e-34 115.15 In-house 4-207 (263) Show / Hide 
Range on Protein: 236-437
Range on HMM: 4-207/263
Sequence Identity: 31% (67 aa)

ANLLGEGGFGRVYRGNLKDGMAVAIKRLSSGGHQGD----KEFLVEVEMLSRLHHRHLVKLVGFFSSR--DSSQHLLCYELVPNGSLESWLH-GRLGANN
   .|.| | .|..|| | |  ||.| . ..  .      ..|. |||.|  . |  |||. |         |      |. . | |    |      . 
DQFIGKGHFSKVHKGNWK-GKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQ

PLDWDT--RMKIAIGAARGLAYLHEDCQPCVIHRDFKASNILLEDNFQAKVADFGLAKQAPEGQTSYVSTRVMGTFGYVAPEYAMTGHLLVKSDVYSYGV
|.  |    .|.|.  |.|...||      .|||| |.||||.  .| .|.||||..      ..    | . ||    .||  |      |||||||..
PIKLDDTLIIKYAFDIAQGMQHLHTR---NFIHRDIKSSNILMDKHFNIKIADFGISRVIDFNFN---MTTIAGTPKWESPECLMHESYNQKSDVYSYAM

VLLELLSGRKP
.| ||. |  |
MLYELATGDEP
Kinase IRAKk_e-2.AA TyrKc 233-508 25 3.1e-34 120.96 SMART 1-280 (280) Show / Hide 
Range on Protein: 233-508
Range on HMM: 1-280/280
Sequence Identity: 25% (76 aa)

FDPANLLGEGGFGRVYRGNLKDGMAVAIKRLSSGGHQGDKEFLVEVEMLSRL--HHRHLVKLVGFFSSR-----DSSQHLLCYELVPNGSLESWLHGRLG
      |||| ||.||.| .|  . ||.| | ..     ..|. | .....|  || ..|.|.|  ..       . ....  |..|.|.| . |. . .
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

ANNPLDWDTRMKIAIGAARGLAYLHEDCQPCVIHRDFKASNILLEDNFQAKVADFGLAKQAPEG------QTSYV-----STRVMGTFGYVAPEYAMTGH
    | ...  .... .|.| .|||.    ..||||  | |.|. .|...|..||||..   ..      .  |.     ... |      |||  ..| 
K---LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

LLVKSDVYSYGVVLLELLS-GRKPVD-MAQ--PTGQENLVTWARPVLKDVDRIYELADPRLNGQYPRE----DFAQVAAVAAACVAPEANQRPTMGEVVQ
   ||||.|.||.. |... | .|   |.|   . ||        |...|.. | .  |  .   |        . .  .   | . ....|||. |...
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQE--------VIEYVKQGYRMPQPPNDY--P-MSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHE

SL
 .
CF
Kinase IRAKk_e-2.AA Pkinase 233-435 26 4.3e-34 121.62 Pfam 1-209 (293) Show / Hide 
Range on Protein: 233-435
Range on HMM: 1-209/293
Sequence Identity: 26% (59 aa)

FDPANLLGEGGFGRVYRG-NLKDGMAVAIKRLSSGGHQGDKE---FLV--EVEMLSRLHHRHLVKLVGFFSSRDSSQHLLCYELVPNG----SLESWLHG
.     .|.|.||.||.. . ..|  ||.|...   |. ...    .   |.... ||.| . |.| ..| .  ..   .. |....|    .| .....
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST

RLGANNPL--DWDTRMKIAIGAARGLAYLHEDCQPCVIHRDFKASNILLEDNFQA----KVADFGLAKQAPEGQTSYVSTRVMGTFGYVAPEYAM-TGHL
   .....  ....  ...   .|||.|.|.     .|||| | .|||. .| .     |..|||||||.     .   | . || .|.|||  .   . 
--WRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYY

LVKSDVYSYGVVLLELLSGR
  |.|..|.|..| |.|.||
GPKVDMWSCGCILYEMLCGR
Kinase IRAKk_e-2.AA RIPK 239-437 28 4.6e-33 110.0 In-house 1-227 (290) Show / Hide 
Range on Protein: 239-437
Range on HMM: 1-227/290
Sequence Identity: 28% (65 aa)

LGEGGFGRVYRGNLKDGMAVAIKRLSSGGH-------QGDKEFLVEVEMLSRLHHRHLVKLVGFFSSRDSSQHLLCYELV----PNGSLESWLHGRLG-A
.| |||| |..   ..   ...|  . . |       |  .. . |.... .| ..| |.. ||    .  ..   | .|    .||||.  || .    
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ

NNPLDWDTRMKIAIGAARGLAYLHEDCQPCVIHRDFKASNILLEDNFQAKVADFGLAKQAPEGQTSYVST-RV-------------MGTFGYVAPEYAMT
. |. |. |  .    ..|  ||| . .| .|||| | .|||.  || .|.||||||.     ..| . . |               ||  | .||   |
HHPDPWPLRCRMIHEISCGMCYLH-SMNPPIIHRDLKPENILVDNNFHVKIADFGLATWM---MWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRT

GHLLV------KSDVYSYGVVLLELLSGRKP
.          |.||||...|. |.|....|
DNKKPIKVVTPKYDVYSFAIVMWEVLTQKHP
Kinase IRAKk_e-2.AA MLK 233-437 25 6.6e-33 111.53 In-house 1-235 (291) Show / Hide 
Range on Protein: 233-437
Range on HMM: 1-235/291
Sequence Identity: 25% (61 aa)

FDPANLLGEGGFGRVYRGNLKDGMA-----VAIKRLS----SGGHQG--DKEFLVEVEMLSRLHHRH----LVKLVGFFSSRDSSQHLLCYELVPNGSLE
..    .|.|.|| |..|. . ..      ||.||      . .  .  ...|  |.. |..| |.      ....|  ..   .. ..  | ...||| 
IQFHEWIGSGSFGKVWKGRWR-NKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPP-CHFCIVMEYCEGGSLY

SWLHGRLGANN----------PLDWDTRMKIAIGAARGLAYLHEDCQPCVIHRDFKASNILLED------NFQAKVADFGLAK--QAPEGQTSYVSTRVM
. |||. .  .            | |  |..|   |||..|||.. .. .|||| | .|||. .      . ..|..|||...  .  . ..    .  .
NVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TN---MMSNA

GTFGYVAPEY---AMTGHLLVKSDVYSYGVVLLELLSGRKP
||. . |||    .  .    |.||.|.|||| |.|... |
GTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVP
Kinase IRAKk_e-2.AA STE 233-435 20 2.2e-31 108.09 In-house 1-265 (359) Show / Hide 
Range on Protein: 233-435
Range on HMM: 1-265/359
Sequence Identity: 20% (56 aa)

FDPANLLGEGGFGRVYRGNLKD----------------GMAVAIKRLSSGG-----------------HQGDKEFLVEVEMLSRLH--HRHLVKLVGFFS
..    .|.|.|| ||..  ..                |  .|||...                    |.  ...| |........  | . ||  | . 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

SRD-----SSQHLLCYELVPNGSLESWLHGRLGANNPLD----------WDTRMKIAIGAARG-LAYLHEDCQPCVIHRDFKASNILLEDNFQAKVADFG
  .      ..  .| |....|||.. .. . | ..||.           .   .|.    .| |.|||.     .|||| |..||||     .| .|||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDFG

LAKQAPEG--------------QTSYVSTRVMGTFGYVAPEYAMT------GHLLVKSDVYSYGVVLLELLSGR
...|  .                ..  .. . ||  . |||  .       ..  .|.|..| | ...|.. |.
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK
Kinase IRAKk_e-2.AA TK 476-508 18 0.000234 9.67 In-house 454-486 (486) Show / Hide 
Range on Protein: 476-508
Range on HMM: 454-486/486
Sequence Identity: 18% (6 aa)

PREDFAQVAAVAAACVAPEANQRPTMGEVVQSL
|... . .. .   | ......|||. .... |
PHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase IRAKk_e-2.AA IRAK 486-508 39 0.003964 7.13 In-house 295-317 (317) Show / Hide 
Range on Protein: 486-508
Range on HMM: 295-317/317
Sequence Identity: 39% (9 aa)

VAAACVAPEANQRPTMGEVVQSL
.|  |..  || |..| .|.|.|
CACCCGHHRANRRCDMAWVMQQL
Kinase IRAKk_e-2.AA MLK 490-508 31 0.007748 5.83 In-house 273-291 (291) Show / Hide 
Range on Protein: 490-508
Range on HMM: 273-291/291
Sequence Identity: 31% (6 aa)

CVAPEANQRPTMGEVVQSL
|  .....||.. ..|| |
CWNQDPHKRPSFRQIVQHL
Kinase IRAKk_e-2.AA Dicty4-Unclassified 490-508 42 0.014416 4.57 In-house 245-263 (263) Show / Hide 
Range on Protein: 490-508
Range on HMM: 245-263/263
Sequence Identity: 42% (8 aa)

CVAPEANQRPTMGEVVQSL
|   . | |||| ...| |
CWHNDPNKRPTMNQIIQYL
Kinase IRAKk_e-2.AA Dicty4 496-510 29 0.10659 1.64 In-house 261-277 (277) Show / Hide 
Range on Protein: 496-510
Range on HMM: 261-277/277
Sequence Identity: 29% (5 aa)

NQRPTMGEVVQS--LKM
..||.. |..|   |  
QHRPSFEEIIQRRILEH
Kinase IRAKk_e-2.AA Pkinase_Tyr 490-508 31 0.26629 5.03 Pfam 252-270 (270) Show / Hide 
Range on Protein: 490-508
Range on HMM: 252-270/270
Sequence Identity: 31% (6 aa)

CVAPEANQRPTMGEVVQSL
| ......|||. |... |
CWHYDPEDRPTFSEIHEQL
Kinase IRAKk_e-2.AA TKL-Unique 489-508 30 0.285333 0.46 In-house 271-290 (290) Show / Hide 
Range on Protein: 489-508
Range on HMM: 271-290/290
Sequence Identity: 30% (6 aa)

ACVAPEANQRPTMGEVVQSL
.| ...  |||.  |.. .|
QCWHHDPSQRPSFDEIIHRL
Kinase IRAKk_e-2.AA LRRK 490-510 23 0.318608 0.06 In-house 331-351 (351) Show / Hide 
Range on Protein: 490-510
Range on HMM: 331-351/351
Sequence Identity: 23% (5 aa)

CVAPEANQRPTMGEVVQSLKM
| . . ..||.. ..|. |. 
CWQHDPKKRPHFSQIVKRLSQ