Gene IRAKk_f (S.moellendorffii)

IRAKk_f

Species: S.moellendorffii
Alias: IRAKk_f
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAKk

Sequence

Name Sequence Type Origin Length Description Download
IRAKk_f.AA Protein None 269 None Fasta, JSON
IRAKk_f.NA RNA None 810 None Fasta, JSON
IRAKk_f.kin_dom Protein Kinase Domain None 158 None Fasta, JSON

Protein domain

Protein domains of IRAKk_f.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IRAKk_f.AA IRAK 9-169 36 1.5e-63 217.42 In-house 46-225 (317) Show / Hide 
Range on Protein: 9-169
Range on HMM: 46-225/317
Sequence Identity: 36% (65 aa)

FFQA---EINLMGRIHHPNLIALLGFSSQGEDRLLIYELMTNGSLQDQLQGPAQGAA---LTWHLRLKIALDAARGLEYLHDHC-DPPVIHRDFKSSNIL
.||.   |. .. |..|||. .|.|.......  |.|..|.||||.|.|.. ..  .   |.|| |..|.. .|.|...||.     |.||.| ||.|||
RFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQCPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANIL

LDEDFNAKLSDFGLALMV----QEGAGSL------QLQGTFGYVAPEYIL--TGILTEKSDVYAFGVVLLELITGRKPID
||..|..|..||||.          ....       ..||  | .||.|   .|.|| |.||| ||.||||..||... .
LDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQLTKKTDVYSFGIVLLEVLTGCRAVY
Kinase IRAKk_f.AA TKL 9-167 26 1.3e-55 191.07 In-house 71-288 (364) Show / Hide 
Range on Protein: 9-167
Range on HMM: 71-288/364
Sequence Identity: 26% (61 aa)

FFQAEINLMGRIHHPNLIALLGFSSQGED-------------RLLIYELMTNGSLQDQLQGPAQGAALTWHLRLKIALDAARGLEYLHDHCD-----PPV
|.  ||..| |..|||.. ..|.. ....               ...|.. .||| ..|.         ||.|...|||.|||..||| .       ||.
FEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPI

IHRDFKSSNILLDEDFN--------------AKLSDFGLALMVQEGAG--------------------SLQLQGTFGYVAPEYIL---------------
|||| ||.|||.||...              .|..||||. ....  .                    .    ||... ||| .                
IHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFC

-TGILTEKSDVYAFGVVLLELITGRKP
  .  .||.|||.||.|| |..|...|
KGFEYSEKCDVYSFGIVLWEILTRCRP
Kinase IRAKk_f.AA LRRK 10-169 34 5.4e-42 145.83 In-house 104-284 (351) Show / Hide 
Range on Protein: 10-169
Range on HMM: 104-284/351
Sequence Identity: 34% (63 aa)

FQAEINLMGRIHHPNLIALLGFSSQGEDRLLIYELMTNGSLQDQLQGPAQGA------ALTWHLRLKIALDAARGLEYLHDHCDPPVIHRDFKSSNILL-
|. |. .| . .|||.. |.||.   . . .. |....|.|.. |. ..| .       ..|.|.|||||. |.|.||||.| .||.|||| || |||| 
FRHEVWIMSHLNHPNIVSLKGFCI--HPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSH-NPPIIHRDLKSPNILLW

--D---------EDFNAKLSDFGLAL--MVQEGAGSLQLQGTFGYVAPEYILTG---ILTEKSDVYAFGVVLLELITGR-KPID
  .         .. .||..|||.     .   ..   . |..|..||| .  .     |||.|.|.||..| ||.|..  | |
SSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFD
Kinase IRAKk_f.AA TKL-Unique 10-164 34 4.9e-37 128.2 In-house 42-224 (290) Show / Hide 
Range on Protein: 10-164
Range on HMM: 42-224/290
Sequence Identity: 34% (63 aa)

FQAEINLMGRIH-HPNLIALLGFSS----QGEDRLLIYELMTNGSLQDQLQ-------GPAQGAALTWHLRLKIALDAARGLEYLHDHCDPPVIHRDFKS
|  |.|.| ..| |||.  . |..     .  .. .. | .  ||| | |.         ..   |.. .|.|.|.|.|.|..||| ||.||.|||| ||
FENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLH-HCEPPIIHRDLKS

SNILLDED-----FNAKLSDFGLALMVQEG-AGSLQ---------LQGTFGYVAPEYILTG---ILTEKSDVYAFGVVLLELITG
||.|.|..     .|.|..||||.       ....           .|.| ..||| .|..     .||||||.||.|| |..|.
SNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPE-VLRMNFCQYSEKSDVYSFGIVLWEIATR
Kinase IRAKk_f.AA MLK 10-167 29 2.8e-36 123.41 In-house 52-235 (291) Show / Hide 
Range on Protein: 10-167
Range on HMM: 52-235/291
Sequence Identity: 29% (55 aa)

FQAEINLMGRIHHPN----LIALLGFSSQ-GEDRLLIYELMTNGSLQDQLQG-PAQGA----------ALTWHLRLKIALDAARGLEYLHDHCDPPVIHR
|. |...  .. |||     |...| ..| . . ... | . .||| . | | . ...            . .. ...||. |||..||| .  .|.|||
FEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHR

DFKSSNILLDE------DFNAKLSDFGLALMVQEG-AGSLQLQGTFGYVAPEYI---LTGILTEKSDVYAFGVVLLELITGRKP
| ||.|||.||      . ..| .|||.. ....  .     .||. . ||| |     .  .||.||. .|||| |..|.. |
DLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVP
Kinase IRAKk_f.AA Dicty4 10-167 33 8.5e-36 116.98 In-house 45-216 (277) Show / Hide 
Range on Protein: 10-167
Range on HMM: 45-216/277
Sequence Identity: 33% (58 aa)

FQAEINLMGRIHHPNLIALLGFSS----QGEDRLLIYELMTNGSLQDQLQG----PAQGAALTWHLRLK---IALDAARGLEYLHDHCDPPVIHRDFKSS
| .|...|. | |||.. ..| .     . .. .   |.|  |.|   |        |   | | |...   .|.|||||. .||  |.| .|||| ||.
FRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHC-CNPVIIHRDLKSH

NILLDEDFNAKLSDFGLALMVQEGAGSLQ----LQGTFGYVAPEYILTGILTEKSDVYAFGVVLLELITGRKP
|.| |.....| .||||. . ...    .      || ...|||       .||.||| || || |. |.  |
NLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADVYSFGIVLWEILTRQEP
Kinase IRAKk_f.AA Pkinase 12-165 28 4.8e-35 125.0 Pfam 49-209 (293) Show / Hide 
Range on Protein: 12-165
Range on HMM: 49-209/293
Sequence Identity: 28% (47 aa)

AEINLMGRIHHPNLIALLGFSSQGEDRLLIYELMTNG----SLQDQLQGPAQGAAL--TWHLRLKIALDAARGLEYLHDHCDPPVIHRDFKSSNILLDED
.|| .| |..||| . |...   . .  .. |.. .|    .| | ...  .. ..  ...   ....  .|||||.|..    .|||| |..|||.|..
SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST-WRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNN

FNA----KLSDFGLALM--VQEGAGSLQLQGTFGYVAPEYIL-TGILTEKSDVYAFGVVLLELITGR
 .     |..|||||       .     . || .|.||| |.     . |.|....|..| |...||
GHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGR
Kinase IRAKk_f.AA DRK 10-163 37 4.8e-34 112.73 In-house 44-197 (258) Show / Hide 
Range on Protein: 10-163
Range on HMM: 44-197/258
Sequence Identity: 37% (59 aa)

FQAEINLMGRIHHPNLIALLGFSSQGEDRLLIYELMTNGSLQDQLQGPAQGAALTWHLRLKIALDAARGLEYLHDHCDPPVIHRDFKSSNILLDEDFNAK
|. ||||| .  ||| .  .|      | . . | |  |||   |  ..    . | |......|.|.|. |||  |.| .|||| || | | || .  |
FHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDES--IEMDWPLMKQMMFDCAKGMIYLH-CCNPIIIHRDLKSHNLLVDEHWQVK

LSDFGLAL----MVQEGAGSLQLQGTFGYVAPEYILTGILTEKSDVYAFGVVLLELIT
 .||||.     . | ..      || . .|||       ||| ||| |..|| |..|
VADFGLSTRFKKHKQHKFAMTMC-GTPCWTAPEVLRNQRYTEKADVYSFAIVLWECVT
Kinase IRAKk_f.AA TK 10-167 17 2.3e-32 105.2 In-house 88-394 (486) Show / Hide 
Range on Protein: 10-167
Range on HMM: 88-394/486
Sequence Identity: 17% (55 aa)

FQAEINLMG--RIHHPNLIALLGFSSQGED------------RLLIYELMTNGS----LQDQLQGPAQGAA-----------------------------
. .|. .|     ||||.. |.| ..|||              ... |.| .|.    |.| |.    ..                              
EAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYS

--------------------------------------------LTWHLRLKIALDAARGLEYLHDH----CDPPVIHRDFKSSNILLDEDFN-------
                                            || | .| .....|.|.||||..      . ..|||    |.|..|. .       
HESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDG

----AKLSDFGLA------LMVQEGAGSLQLQGTFGY-----------------------------VAPEYIL---------TGILTEKSDVYAFGVVLL
    .|..||||.      |    . ..     . ..                              ||| ..         .|. |.||||..|||.. 
CGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMW

ELIT-GRKP
|. | |..|
EIFTYGQEP
Kinase IRAKk_f.AA RIPK 45-167 33 4.4e-32 106.61 In-house 84-227 (290) Show / Hide 
Range on Protein: 45-167
Range on HMM: 84-227/290
Sequence Identity: 33% (49 aa)

MTNGSLQDQLQGPA--QGAALTWHLRLKIALDAARGLEYLHDHCDPPVIHRDFKSSNILLDEDFNAKLSDFGLALMVQEGAGSLQLQ-------------
| |||| . |.     |   . | ||  .    ..|  |||.  .||.|||| | .|||.| .|..|..|||||   .   .| . |             
MENGSLWHFLHTKWPYQHHPDPWPLRCRMIHEISCGMCYLHSM-NPPIIHRDLKPENILVDNNFHVKIADFGLATWMM---WSHSHQDRCNQREVYSMKS

----GTFGYVAPEYIL------TGILTEKSDVYAFGVVLLELITGRKP
    ||  | .|| ..      . . |.|.||| |..|. |. |...|
KNRWGTLSYMPPEHFRTDNKKPIKVVTPKYDVYSFAIVMWEVLTQKHP
Kinase IRAKk_f.AA CZAK 10-167 34 3.5e-31 109.93 In-house 47-221 (279) Show / Hide 
Range on Protein: 10-167
Range on HMM: 47-221/279
Sequence Identity: 34% (61 aa)

FQAEINLMGRIHHPNLIALLGFSSQGE--DRLLIYELMTNGSLQDQLQGPAQGAALT-WHLRLKIALDAARGLEYLHDHCDP-PVIHRDFKSSNILLDED
|| |.  |    ||| .  ||  | .   ..  . | |  ||| ..|        .   ||....|.| |||  ||||   | |..|||  |.|||||. 
FQKEVSIMSKLCHPNCVQFLGACSEDGPNHHCIVMEWMGGGSL-RRLLTDHYFYHKQNPHLQWNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDHS

FN-------------AKLSDFGLA-LMVQEGAGSLQLQGTFGYVAPEYILTGILTEKSDVYAFGVVLLELITGRKP
               .| .||||  .|   .    |  |   . |||       |||.||| || .| ..||.. |
YTPKNPVVSSRQDIICKINDFGLSREMMEQPFEMTQTMGCLCWMAPECFKGENYTEKVDVYSFGMILWCIITCDQP
Kinase IRAKk_f.AA Pkinase_Tyr 10-116 34 4.1e-28 95.83 Pfam 50-158 (270) Show / Hide 
Range on Protein: 10-116
Range on HMM: 50-158/270
Sequence Identity: 34% (39 aa)

FQAEINLMGRI-HHPNLIALLGFSS-QGED--RLLIYELMTNGSLQDQLQGP-AQGAALTWHLRLKIALDAARGLEYLHDHCDPPVIHRDFKSSNILLDE
| .|...|  . ||||.. |.|  . |||    ... |.| .|.| | |. .  .. .|| .  |..... |.|.|||...     ||||    |.|..|
FMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTE

DFNAKLSDFGLA
.. .| .|||||
NNVVKICDFGLA
TyrKc IRAKk_f.AA TyrKc 4-238 21 6.5e-16 34.64 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-238
Range on HMM: 1-280/280
Sequence Identity: 21% (64 aa)

VTL------------------------------FAFFQAEINLMGRI--HHPNLIALLGFSSQG-------EDRLLIYELMTNGSLQDQLQGPAQGAALT
.||                               . |  |...| ..  ||||...|.|  .|.       |  ... |.| .|.|.| |. .     |.
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK--LC

WHLRLKIALDAARGLEYLHDHCDPPVIHRDFKSSNILLDEDFNAKLSDFGLALMVQEG--------AGSL----QLQ--GTFGYVAPEYILTGILTEKSD
.   |......|.| ||||..   ..||||    |.|..|.. .| |||||.  . ..          .     .          ||| | .|. |.|||
MKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSD

VYAFGVVLLELIT-GRKPIDV---SMPTGCQSLVTWATPQLTDRTRLPLIVD--------AAIKDTVNLKQLFQVAAVAVLCVQSEPSYRPLIGDVVNSL
|..|||.. |. | | .|        .   | .. .    . .. |.|   .        .  .          .  .   | . .|. ||   ...  .
VWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEY----VKQGYRMPQPPNDYPMSFVCCPDE----------MYQIMKQCWHEDPEDRPTFSEIHECF
S_TKc IRAKk_f.AA S_TKc 1-242 20 3.4e-14 31.24 SMART 16-231 (231) Show / Hide 
Range on Protein: 1-242
Range on HMM: 16-231/231
Sequence Identity: 20% (54 aa)

MVAVTLF-----------AFFQAEINLMGRIHHPNLIALLGFSSQGEDRLLIYELMTN--GSLQDQLQGPAQGAA---LTWHLRLKIALDAARGLEYLHD
. ..                .. ||... . ||||.. |...    ..  .. |.. .  |.| | ..    .     ..     ...   ...|||.|.
YKCRHKKTGRIVAIKIIKEHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHS

HCDPPVIHRDFKSSNILLDEDFNAKLSDFGLALMVQEGAGSLQLQGTFGYVAPEYILTGILTEKSDVYAFGVVLLELITGRKPIDVSMPTGCQSLVTWAT
|    .|||| | .||||||  . |..|||||  .        . ||  |.||| .  |  ..|.|....|..| |...|. | .  | .  . ..    
HG---IIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG----

PQLTDRTRLPLIVDAAIKDTVNLKQLFQVAAVAVLCVQSEPSYRPLIGDVVN-----SLIPLV
                           ..      | | .|. || . .. .      . | .
-------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAKk_f.AA Pkinase_Tyr 136-167 51 1.2e-07 26.58 Pfam 182-214 (270) Show / Hide 
Range on Protein: 136-167
Range on HMM: 182-214/270
Sequence Identity: 51% (17 aa)

APEYILTGILTEKSDVYAFGVVLLELIT-GRKP
||| | .|. |.||||..|||.. |..| |..|
APECINYGKFTTKSDVWSFGVLMWEIFTYGEQP