Gene IRAKm_c (S.moellendorffii)

IRAKm_c

Species: S.moellendorffii
Alias: IRAKm_c
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAKm

Sequence

Name Sequence Type Origin Length Description Download
IRAKm_c.AA Protein None 787 None Fasta, JSON
IRAKm_c.NA RNA None 2364 None Fasta, JSON
IRAKm_c.kin_dom Protein Kinase Domain None 195 None Fasta, JSON

Protein domain

Protein domains of IRAKm_c.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
B_lectin IRAKm_c.AA B_lectin 107-204 28 3.1e-20 71.09 Pfam 1-137 (137) Show / Hide 
Range on Protein: 107-204
Range on HMM: 1-137/137
Sequence Identity: 28% (39 aa)

TAAPVWIANRN---TPV-----SGNSMLAKT--GGRLQLLDAN-G-SV--AWSP------NE--SVAYIGIQNSGNLQLF-DES--ETPVWSS--FDRPW
   .|| |||.   .||     .||..|  .   | | |.|.. | ||   ||       .   . ..  .|.|||| |. |..   ...|.|  || | 
NQTVVWVANRDLTGNPVTDSSNNGNYTLTMQNRDGNLVLYDGGNGGSVRPVWSTNNNTSGSGSANNCRAQMQDSGNLVLYDDNNDSNNVLWQSNTFDHPT

SALMPNQKLVT------GQS----VVSNKNAS--DPS
  . |..|| .      ...     .| |...  |||
DTWLPGMKLGWDNNVTIYMNWIGYLTSWKSNTNYDPS
B_lectin IRAKm_c.AA B_lectin 65-178 23 7.1e-10 40.05 SMART 1-126 (126) Show / Hide 
Range on Protein: 65-178
Range on HMM: 1-126/126
Sequence Identity: 23% (31 aa)

DNPSSRPESLRSDDENLG--LAFLNFNGSNKYYLALMFGTRNSSTAAPVWIA--NRNTPVSG---NSMLAKT-GGRLQLLDANGSVAWSPNES----VAY
||. |  ..| |..      | | .|...   ..   ..  . ..  .|| |  ||. ||..   .. |  .  | | ..|  ... || | .    .  
DNTLSSGQTLVSGNSLFEFYLGFFTFIMQ--WCNGIWYKNISNKQRTVVWVAQPNRDNPVHDGNNSCYLTMQSDGNLVIYD--NRPVWSSNTTRNNGNYV

IGIQNSGNLQLFDES----ETPVWSSFDRP
   | .||. ..|..    .  .|.||| |
AVLQDDGNFVIYDPDDNDSGNFIWQSFDHP
PAN_AP IRAKm_c.AA PAN_AP 376-453 15 0.000509 17.96 SMART 1-85 (85) Show / Hide 
Range on Protein: 376-453
Range on HMM: 1-85/85
Sequence Identity: 15% (14 aa)

RYETDFVTLAGASYFANTFNPP-----DRTGAAMQDCLEQCKSTCSCAAFFFDQALQNCFFIE--DVLGSLT------VDSNKTQQLFGFL
  ...|| . ....    |.|          . ...|...|   ||| .| ..   ..| .    . ||. .         | .. ..  .
CCDDCFVRMPNMKL----FSPIVNWVDVI-VMSLEECMQKCLNNCSCRSFMYYN-TKGCHLWSWDSHLGDPRQFKRFMKFPNQGVDYYEKN
PAN_1 IRAKm_c.AA PAN_1 373-431 11 0.000552 14.94 Pfam 1-55 (84) Show / Hide 
Range on Protein: 373-431
Range on HMM: 1-55/84
Sequence Identity: 11% (7 aa)

CSSRYETDFVTLAGASYFANTFNPPDRT-GA-AMQDCLEQCKSTCS--CAAFFFDQALQNCFF
|..   ..|.   ....     . .  . ..  ...|...|    .  | .| .. . ..|..
CHR---WHFERHPNYIL-G---H-IWVMKNVDSAEECQQKCQNNPRFTCRSFTYNYKTKQCHL
Kinase IRAKm_c.AA TKL 477-741 19 4.1e-64 219.31 In-house 1-364 (364) Show / Hide 
Range on Protein: 477-741
Range on HMM: 1-364/364
Sequence Identity: 19% (76 aa)

LGSGGCGTVYEGMLHN---------GMKLAVKKLSTQHGQ-----------------------------KEFVTEVSALGNISHINIVKLYGFCADASH-
.|||| |.|| | ...         |   ||||..... .                             .... |.  . ...| |||...|.| . .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------RLLVYELMPNGSLDRWIFSDNKNKLDWKLRHSIALDTARGLAYLHEESR-----DSIIHLDIKPQNILLGDKFE--------------
              .|.|..|.|||   .         | .|...|||.|||..||| .         ||| |.|..|||. ....              
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC

AKVADFGMAKLLMDRDQNG-----------------VVTGVRGTPGYLAPEWLLHS----------------TATKKCDVYSYGMVLLELIGGRKNLDCS
.|..||| .. .  . ..                      ..|||...||| |  .                ....||||||.|.|| |.. ...     
CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR-----

KMESPLS-WYFPAWAMS----EIRKGNTMQVVDPSVKD--------SADTRQAKNMIHIAFWCTQDDPAARPTMDAVVRML
    | .   .. . ..    |. ...      | ...        .  .   . |. .. .| . || .||... ..  |
----PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAKm_c.AA Pkinase 473-741 22 9.2e-53 186.4 Pfam 3-293 (293) Show / Hide 
Range on Protein: 473-741
Range on HMM: 3-293/293
Sequence Identity: 22% (71 aa)

FTKVLGSGGCGTVYEGMLHNGMK-LAVKKLSTQHGQKEFVT-------EVSALGNISHINIVKLYGFCADASHRLLVYELMPNG----SLDRWIFSDNKN
. ...|||. |.||... ..  |  |||... . ..|. .        |.. . ...| |||.||... | .|  .| |....|    .| ..|  ....
IGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHG

KL--DWKLRHSIALDTARGLAYLHEESRDSIIHLDIKPQNILLGDKFEA----KVADFGMAKLLMDRDQNGVVTGVRGTPGYLAPEWLL-HSTATKKCDV
..  ...   .... ..|||.|.|..   .||| |.||.|||. .. .     |..||| ||..     |.  |.. |||.|.|||... ..  ..|.|.
CFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

YSYGMVLLELIGGRKNLDCSKMESPLSWYFPA---------WAMSEIRKGNTMQVVDPSVKDS------------ADTRQAKNMIHIAFWCTQDDPAARP
.|.| .| |.. ||           . ..  .         . . .|... ..   . .   |              ... ......  || . ||. ||
WSCGCILYEMLCGR-----------PPFP-GHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTF-HNWSEECKDFIKWCLCKDPKKRP

TMDAVVRM--L
| . ..    .
TAEQILQHPWF
Kinase IRAKm_c.AA TKL-Unique 473-664 28 1e-47 164.86 In-house 1-222 (290) Show / Hide 
Range on Protein: 473-664
Range on HMM: 1-222/290
Sequence Identity: 28% (64 aa)

FTKVLGSGGCGTVYEGMLHNGMKLAVKKLST---QHGQ--KEFVTEVSALGNIS-HINIVKLYGFCA----DASHRLLVYELMPNGSLDRWIFS------
| ...|.||.|.|| |. ..| . |.|...    .. .  .||  ||. . ..  |.|||...|.|.    ..... .| | .| |||.  .        
FWNKIGEGGYGQVYKGK-WRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

--DNKNKLDWKLRHSIALDTARGLAYLHEESRDSIIHLDIKPQNILLGDK-----FEAKVADFGMAKLLMDRDQNGVV-------TGVRGTPGYLAPEWL
   |..||....| ..|.| |.|. ||| ..   |||.|.|..|.|.  .     . .|..||| .|..  .... .        ... |.. ..||| |
NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVL

LH--STATKKCDVYSYGMVLLELI
    .. ..|.||||.|.|| |..
RMNFCQYSEKSDVYSFGIVLWEIA
Kinase IRAKm_c.AA Dicty4 473-663 32 5.6e-44 144.66 In-house 3-210 (277) Show / Hide 
Range on Protein: 473-663
Range on HMM: 3-210/277
Sequence Identity: 32% (68 aa)

FTKVLGSGGCGTVYEGMLHNGMKLAVKKL-STQHGQ-----KEFVTEVSALGNISHINIVKLYGFCA----DASHRLLVYELMPNGSLDRWIFS-----D
... .|.|..|.|| |    | . ||||| ... .      .||  ||. ...|.| ||....| |       .  . | |.|| |.| . . .      
IEQRIGKGSFGEVYKGTWR-GKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQ

NKNKLDWKLRHS---IALDTARGLAYLHE-ESRDSIIHLDIKPQNILLGDKFEAKVADFGMAKLLMDRDQNGV-VTGVRGTPGYLAPEWLLHSTATKKCD
 . |||| |. .   .|.|.|||...||.  ..  |||.|.|. |.|  . . .||.||| ...     ...   ... |||.. ||| . |   . | |
QSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV--IIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKAD

VYSYGMVLLEL
|||.|.|| |.
VYSFGIVLWEI
Kinase IRAKm_c.AA IRAK 473-668 36 4e-42 146.27 In-house 1-222 (317) Show / Hide 
Range on Protein: 473-668
Range on HMM: 1-222/317
Sequence Identity: 36% (81 aa)

FTK--VLGSGGCGTVYEGMLHNGM-KLAVK------KLSTQHGQKEFVT---EVSALGNISHINIVKLYGFCADASHRLLVYELMPNGSL-DRWIFSDNK
| |  ..|.|| |.|| | ..|     |||      ..|.    ..| .   |. ..  . | ||| |||.|.. .   |||..|||||| ||    |. 
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

NK---LDWKLRHSIALDTARGLAYLHEES-RDSIIHLDIKPQNILLGDKFEAKVADFGMAKLL---MDRDQNGV----VTGVRGTPGYLAPEWLL--HST
.    | |  |.||.. ||.|. .||. .   .||| |||. |||| . |..| .|||..       .. .  .    .  ||||  |..|| .      
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQ

ATKKCDVYSYGMVLLELIGGRK
 ||| |||| | ||||.. |..
LTKKTDVYSFGIVLLEVLTGCR
Kinase IRAKm_c.AA MLK 471-664 28 2.7e-40 137.53 In-house 1-230 (291) Show / Hide 
Range on Protein: 471-664
Range on HMM: 1-230/291
Sequence Identity: 28% (66 aa)

KGFTKVLGSGGCGTVYEGMLHNGMK-----LAVKKLS--------TQHGQKEFVTEVSALGNISHIN----IVKLYGFCADA-SHRLLVYELMPNGSLDR
  | ...|||. | |. |  .| .      .|||.          |   |..| .|.  |  .|| |    |...|| |..  .| ..| | ...||| .
IQFHEWIGSGSFGKVWKGRWRN-KDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

WIFSD--------NKNK----LDWKLRHSIALDTARGLAYLHEESRDSIIHLDIKPQNILLGD------KFEAKVADFGMAKLLMDRDQNGVVTGVRGTP
 . .         ...|     |  .  ..||. |||..|||.. .. ||| |.|..|||. .      .  .|..||| .. . ....|   .. .||.
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTN--MMSNAGTY

GYLAPEWL---LHSTATKKCDVYSYGMVLLELI
 . ||| .    ... ..||||.|.|.|| |..
AWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEML
Kinase IRAKm_c.AA LRRK 471-664 25 1.3e-37 130.59 In-house 1-276 (351) Show / Hide 
Range on Protein: 471-664
Range on HMM: 1-276/351
Sequence Identity: 25% (71 aa)

KGFTKVLGSGGCG-TVYEGMLHN---------------------------GMKLAVKKLSTQ------------------------------------HG
  . . .|.|| | .|| . . .                           . . |.||. .                                     . 
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

QKEFVTEVSALGNISHINIVKLYGFCADASHRLLVYELMPNGSLDRWIFSDNKNK-------LDWKLRHSIALDTARGLAYLHEESRD-SIIHLDIKPQN
  ||  ||. . .  | |||.|.||| .  .. .| |..|.|.|.. ...  ...       ..| |.. |||. |.|..|||  |.. .||| | |. |
FREFRHEVWIMSHLNHPNIVSLKGFCIH--PLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLH--SHNPPIIHRDLKSPN

ILL-GDK-----------FEAKVADFGMAKLLMDRDQNGVVTGVRGTPGYLAPEWLL---HSTATKKCDVYSYGMVLLELI
||| . .             ||.||||    .   ...||. |. |.||..||| .     .. | | |.||.||.| ||.
ILLWSSPQNHSPNYPNAHVCAKIADFGISR-MFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELL
Kinase IRAKm_c.AA Dicty4-Unclassified 508-666 39 3.7e-37 124.77 In-house 43-204 (263) Show / Hide 
Range on Protein: 508-666
Range on HMM: 43-204/263
Sequence Identity: 39% (67 aa)

KEFVTEVSALGNISHINIVKLYGFCADA-SHR---LLVYELMPNGSLDRWIF-----SDNKNKLDWKLRHSIALDTARGLAYLHEESRDSIIHLDIKPQN
..|  ||  || |.| | ||.|| |    ||.     | |.|. | |   |       .   |||  |   .|.| |.|...||  .|. .|| |||  |
QDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQPIKLDDTLIIKYAFDIAQGMQHLH--TRN-FIHRDIKSSN

ILLGDKFEAKVADFGMAKLLMDRDQNGVVTGVRGTPGYLAPEWLLHSTATKKCDVYSYGMVLLELIGG
||.   | .|.||||..      | |   | . |||   .|| | |   . | |||||.|.| ||. |
ILMDKHFNIKIADFGISRVI---DFNFNMTTIAGTPKWESPECLMHESYNQKSDVYSYAMMLYELATG
Kinase IRAKm_c.AA S_TKc 471-741 23 1.2e-36 128.98 SMART 1-231 (231) Show / Hide 
Range on Protein: 471-741
Range on HMM: 1-231/231
Sequence Identity: 23% (69 aa)

KGFTKVLGSGGCGTVYEGMLHN-GMKLAVKKLSTQHGQKEFVTEVSALGNISHINIVKLYGFCADASHRLLVYELMPN--GSLDRWIFSDNKNK----LD
  . ...|.|. |.|| .  .. | . |.|...     . .  |.. | .  | ||||||... | .|  .| |....  |.| . | . ....    ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP

WKLRHSIALDTARGLAYLHEESRDSIIHLDIKPQNILLGDKFEAKVADFGMAKLLMDRDQNGVVTGVRGTPGYLAPEWLLHSTATK-KCDVYSYGMVLLE
     ...  ....|.|.|.     ||| |.||.|||| .  . |..|||.|..|         | . ||| |.||| |     .| |||..| | .| |
E-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

LIGGRKNLDCSKMESPLSWYFPAWAMSEIRKGNTMQVVDPSVKDSADTRQAKNMIHIAFWCTQDDPAARPTMDAVVR---------ML
.. |.   .               .| .. .                    . ....   | | ||. |||   . .          .
MLCGYPPFP------------QMQMMFKKIG-------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAKm_c.AA Pkinase_Tyr 473-664 27 8e-34 115.18 Pfam 3-208 (270) Show / Hide 
Range on Protein: 473-664
Range on HMM: 3-208/270
Sequence Identity: 27% (59 aa)

FTKVLGSGGCGTVYEGMLH-----NGMKLAVKKL--STQHGQ---KEFVTEVSALGNI-SHINIVKLYGFCA-DASH--RLLVYELMPNGSLDRWIFSD-
| |.||.|  |.||.| ..     .... |||.|  .. | |   ..|  |.. . .. .| |||.||| |  .  .   ..| |.||.|.|.    .  
FGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHR

-NKNKLDWKLRHSIALDTARGLAYLHEESRDSIIHLDIKPQNILLGDKFEAKVADFGMAKLLMDRDQNGVVTG------VRGTPGYLAPEWLLHSTATKK
 .|..|. |   ..... |.|..||..     .|| |.   |.|..... .|..|||.|..... |.  ....      .. .    ||| . ..  | |
EDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWM----APECINYGKFTTK

CDVYSYGMVLLELI
 ||.|.| .. |..
SDVWSFGVLMWEIF
Kinase IRAKm_c.AA STE 473-667 22 9.3e-33 113.04 In-house 1-265 (359) Show / Hide 
Range on Protein: 473-667
Range on HMM: 1-265/359
Sequence Identity: 22% (63 aa)

FTK--VLGSGGCGTVYEGMLHN----------------GMKLAVKKLSTQHG-------------------QKEFVTEVSALGNIS--HINIVKLYGFCA
...  ..|.|..|||| .| |.                |   |.|... ..                    ....  |.. . . .  | |||| || . 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DA-------SHRLLVYELMPNGSLDRWIF---SDNKN---------KLDWKLRHSIALDTARG-LAYLHEESRDSIIHLDIKPQNILLGDKFEAKVADFG
.        ..  .. |.|..||||  |    . .|.         ... ..   |. .. .| |.|||.     ||| ||||.||||     .| .|||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDFG

MAKLLMD--------------RDQNGVVTGVRGTPGYLAPEWLLH------STATKKCDVYSYGMVLLELIGGR
 .. | |               .. .  . . ||| . ||| ..       .  . |||..| | ...|.. |.
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK
Kinase IRAKm_c.AA TK 473-663 15 1.6e-32 105.74 In-house 3-387 (486) Show / Hide 
Range on Protein: 473-663
Range on HMM: 3-387/486
Sequence Identity: 15% (60 aa)

FTKVLGSGGCG---TVYEGMLHNG--------------------------MKLAVKKLS--TQHGQKEFVT--------------EVSALGNIS-----H
. |.||.|  |   .||.|.....                          .. ||| |   . . |.||                |....   .     |
LGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHH

INIVKLYGFCADA------------SHRLLVYELMPNGS----LDRWIF--SDNKNK-------------------------------------------
 |||.||| | .              . ..| |.||.|.    |. .    ......                                           
PNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDD

-----------------------------LDWKLRHSIALDTARGLAYLHEE----SRDSIIHLDIKPQNILLGDKFE-----------AKVADFGMAK-
                             |. . .. .... |.|..|||.         ..| |.   |.|.|..             .|.||||... 
DLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

------LLMDRDQNGVVTGVRGTPG-------------------------YLAPEWLL---------HSTATKKCDVYSYGMVLLEL
        ...|.. .... .||..                         ..||| |.         . . | | ||.|.| .. |.
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEI
Kinase IRAKm_c.AA DRK 478-664 33 1.1e-31 104.63 In-house 8-196 (258) Show / Hide 
Range on Protein: 478-664
Range on HMM: 8-196/258
Sequence Identity: 33% (65 aa)

GSGGCGTVYEGMLHNGMKLAVKKLSTQHGQ-----KEFVTEVSALGNISHINIVKLYGFCADASHRLLVYELMPNGSLDRWIFSDNKNKLDWKLRHSIAL
| |..| |. |    | . |||.|           .||  |.  . .  | ||.   | |   .  . . | || ||| . |  | . ..|| |. ....
GRGNYGEVFRGTWR-GTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYN-ILHDESIEMDWPLMKQMMF

DTARGLAYLHEESRDSII-HLDIKPQNILLGDKFEAKVADFGMAK-LLMDRDQNGVVTGVRGTPGYLAPEWLLHSTATKKCDVYSYGMVLLELI
| |.|. |||  ... || | | |  | |  . .  |||||| .      ...    | . |||.  ||| |     | | ||||.. || |..
DCAKGMIYLH--CCNPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQHKFAMTMC-GTPCWTAPEVLRNQRYTEKADVYSFAIVLWECV
Kinase IRAKm_c.AA TyrKc 473-741 24 3.5e-26 94.23 SMART 3-280 (280) Show / Hide 
Range on Protein: 473-741
Range on HMM: 3-280/280
Sequence Identity: 24% (72 aa)

FTKVLGSGGCGTVYEGMLHNGMKLAVKKLSTQHGQKEFVTEVSALGNI--SHINIVKLYGFCADA-------SHRLLVYELMPNGSLDRWI-FSDNKNKL
. |.||.|  |.||.|..   .. |||.|   . ...|  | . . ..  .| |||.||| | .           ..| |.||.|.|.  .  . .|  |
LGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK--L

DWKLRHSIALDTARGLAYLHEESRDSIIHLDIKPQNILLGDKFEAKVADFGMAKLLMDR-------DQNGVVT--GVR--GTPGYLAPEWLLHSTATKKC
 .|  .|.... |.| .|||.     .|| |.   |.|.|... .|..|||... . |        |   . .  | .       .||| . ... | | 
CMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKS

DVYSYGMVLLELIGGRKNLDCSKMESPLSW-----YFPAWAMSEIRKGNTMQVVDP----SVKDSADTRQAKNMIHIAFWCTQDDPAARPTMDAVVRML
||.|.| .. |.        ..  ..| .        .. ..  ...|. |   .     |   .   .  . |  |  .| . ||. |||. .... .
DVWSFGVCMWEI--------FTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS---F--VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase IRAKm_c.AA TK 723-741 36 7.9e-05 11.28 In-house 468-486 (486) Show / Hide 
Range on Protein: 723-741
Range on HMM: 468-486/486
Sequence Identity: 36% (7 aa)

CTQDDPAARPTMDAVVRML
| . ||. |||.......|
CWHYDPEDRPTFSQLHEQL
Kinase IRAKm_c.AA DRK 723-743 38 0.000106 11.89 In-house 238-258 (258) Show / Hide 
Range on Protein: 723-743
Range on HMM: 238-258/258
Sequence Identity: 38% (8 aa)

CTQDDPAARPTMDAVVRMLES
|   ||  ||.|. ..  ||.
CWNEDPQHRPSMQECLERLEA
Kinase IRAKm_c.AA Dicty4-Unclassified 722-741 45 0.000317 10.33 In-house 244-263 (263) Show / Hide 
Range on Protein: 722-741
Range on HMM: 244-263/263
Sequence Identity: 45% (9 aa)

WCTQDDPAARPTMDAVVRML
||  .||  ||||. ..  |
WCWHNDPNKRPTMNQIIQYL
Kinase IRAKm_c.AA LRRK 722-743 36 0.002292 7.75 In-house 330-351 (351) Show / Hide 
Range on Protein: 722-743
Range on HMM: 330-351/351
Sequence Identity: 36% (8 aa)

WCTQDDPAARPTMDAVVRMLES
.| | ||  ||..  .|  |..
HCWQHDPKKRPHFSQIVKRLSQ
Kinase IRAKm_c.AA MLK 723-741 36 0.03295 3.62 In-house 273-291 (291) Show / Hide 
Range on Protein: 723-741
Range on HMM: 273-291/291
Sequence Identity: 36% (7 aa)

CTQDDPAARPTMDAVVRML
| ..||. ||... .|  |
CWNQDPHKRPSFRQIVQHL
Kinase IRAKm_c.AA Dicty4 722-743 33 0.096902 1.78 In-house 254-277 (277) Show / Hide 
Range on Protein: 722-743
Range on HMM: 254-277/277
Sequence Identity: 33% (8 aa)

WCTQDDPAARPTMDAVVRM--LES
||   ||  ||..  ..    ||.
WCWDHDPQHRPSFEEIIQRRILEH
Kinase IRAKm_c.AA Pkinase_Tyr 727-741 40 0.113063 6.29 Pfam 256-270 (270) Show / Hide 
Range on Protein: 727-741
Range on HMM: 256-270/270
Sequence Identity: 40% (6 aa)

DPAARPTMDAVVRML
||. |||. .....|
DPEDRPTFSEIHEQL
Kinase IRAKm_c.AA TKL-Unique 723-741 36 0.335219 0.21 In-house 272-290 (290) Show / Hide 
Range on Protein: 723-741
Range on HMM: 272-290/290
Sequence Identity: 36% (7 aa)

CTQDDPAARPTMDAVVRML
|  .||  ||. | ..  |
CWHHDPSQRPSFDEIIHRL