Gene IRAKm_e (S.moellendorffii)

IRAKm_e

Species: S.moellendorffii
Alias: IRAKm_e
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAKm

Sequence

Name Sequence Type Origin Length Description Download
IRAKm_e.AA Protein None 854 None Fasta, JSON
IRAKm_e.NA RNA None 2565 None Fasta, JSON
IRAKm_e.kin_dom Protein Kinase Domain None 270 None Fasta, JSON

Protein domain

Protein domains of IRAKm_e.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
B_lectin IRAKm_e.AA B_lectin 114-213 24 1.3e-18 65.48 Pfam 1-137 (137) Show / Hide 
Range on Protein: 114-213
Range on HMM: 1-137/137
Sequence Identity: 24% (34 aa)

AGAPIWTANRS---KAVSNES-----RLTKTA--GQLKLLNGD-L-TT--AWSP----SDDQ--TIASIGLDETGNMVLY-NSS--GGAVWES--FDHPT
   . |.|||    . |.. |     .|| ..  | | |..|.   ..   ||     |     . ..  . ..|| ||| ...  . ..|.|  |||||
NQTVVWVANRDLTGNPVTDSSNNGNYTLTMQNRDGNLVLYDGGNGGSVRPVWSTNNNTSGSGSANNCRAQMQDSGNLVLYDDNNDSNNVLWQSNTFDHPT

DVLLPGQRLVT------GQR----FASNLNSS--TMS
| .|||..| .      ...    ..|  ...    |
DTWLPGMKLGWDNNVTIYMNWIGYLTSWKSNTNYDPS
B_lectin IRAKm_e.AA B_lectin 72-187 23 2.7e-11 44.77 SMART 1-126 (126) Show / Hide 
Range on Protein: 72-187
Range on HMM: 1-126/126
Sequence Identity: 23% (30 aa)

NGSSGEQEFLLSDNGTFG--LAFLNFNGTGNYYLSLVMGATNATAGAPIWTA--NRSKAVSN---ESRLTKT-AGQLKLLNGDLTTAWSPSDD--QTIAS
.   .. ..| |.|..|   | | .|..    ... . .  .     ..| |  || . |..   ...|| .  | | ...   .. || . .  .   .
DNTLSSGQTLVSGNSLFEFYLGFFTFIMQ--WCNGIWYKNISNKQRTVVWVAQPNRDNPVHDGNNSCYLTMQSDGNLVIYD--NRPVWSSNTTRNNGNYV

IGLDETGNMVLYNSS----GGAVWESFDHP
  | ..||.|.|...    |. .|.|||||
AVLQDDGNFVIYDPDDNDSGNFIWQSFDHP
Kinase IRAKm_e.AA TKL 550-814 22 2.3e-69 236.78 In-house 1-364 (364) Show / Hide 
Range on Protein: 550-814
Range on HMM: 1-364/364
Sequence Identity: 22% (84 aa)

LGTGGFGSVYEGVLRD---------GKKLAVKKLHSNKGQ-----------------------------KQFIAEVASLGTISHVNIVRLCGFCAELSH-
.| |||| || |..|          ||  ||||..|.  .                             .... |. ..  ..| |||.. |.| . .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------RLLVYEFMPNGSLDKWIFRNQEAPLDWDRRYSIALGTARGLAYLHEESR-----EPIIHLDIKPQNILLDENFE--------------
              .|.|..|.|||   .         |..| ..||..|||..||| .        |||| |.|..|||.|||..              
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC

AKVGDFGMAK-LLMSRDVTQVITG----------------VRGTPGYLAPEWLLSN----------------TATKKCDVYSYGMVLLELIGGRKNLDPA
.|..||| .. . .| . .   |.                ..|||...||| |  .                ....||||||.|.|| |.. ...     
CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR-----

KIDSELSFFFPAWAVNEVKQGRLLSVVDPKIRDGVD------------NQGAERMVKVAFWCIQENPADRPTMDAVIQML
   ... .. . ..     .  .  |.| . |  ..            ..  ..| | . .| ...| .||... ... |
-PYYDYPYMPMIFQD-P-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAKm_e.AA IRAK 546-741 38 8.1e-53 181.79 In-house 1-222 (317) Show / Hide 
Range on Protein: 546-741
Range on HMM: 1-222/317
Sequence Identity: 38% (86 aa)

FSKH--LGTGGFGSVYEGVLRDGK-KLAVKKLHSNKG------QKQFIA---EVASLGTISHVNIVRLCGFCAELSHRLLVYEFMPNGSL-DKWIFRNQE
|.|   .| |||| || |...      |||||....        ..| .   |. .. .. | ||| | |.|.| .   |||..|||||| |    ... 
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

AP---LDWDRRYSIALGTARGLAYLHEES-REPIIHLDIKPQNILLDENFEAKVGDFGMAKLL--MSRDVTQVI-----TGVRGTPGYLAPEWLL--SNT
 |   | | .| ||..|||.|. .||. .   |||| |||. |||||..|..| .|||..      |    |..       ||||  |..|| .   .  
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQ

ATKKCDVYSYGMVLLELIGGRK
 ||| |||| | ||||.. |..
LTKKTDVYSFGIVLLEVLTGCR
Pkinase IRAKm_e.AA Pkinase 544-740 28 6.4e-51 180.29 Pfam 1-209 (293) Show / Hide 
Range on Protein: 544-740
Range on HMM: 1-209/293
Sequence Identity: 28% (61 aa)

KAFSKHLGTGGFGSVYEGVLRDGKK-LAVKKLHSNKGQKQFI------AEVASLGTISHVNIVRLCGFCAELSHRLLVYEFMPNG----SLDKWIFRNQE
  . . .| |.||.||... ..  |  |||..   .  ...       .|.. .  ..| ||||| ... . .|  .| |....|    .|  .| . ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

APL--DWDRRYSIALGTARGLAYLHEESREPIIHLDIKPQNILLDENFEA----KVGDFGMAKLLMSRDVTQVITGVRGTPGYLAPEWLL-SNTATKKCD
 ..  ...   .... ..|||.|.|..    ||| |.||.|||.|.| .     |..||| ||..      .  |.. |||.|.|||... ..  ..|.|
GCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVD

VYSYGMVLLELIGGR
..|.| .| |.. ||
MWSCGCILYEMLCGR
Kinase IRAKm_e.AA TKL-Unique 546-737 29 1.8e-47 164.02 In-house 1-222 (290) Show / Hide 
Range on Protein: 546-737
Range on HMM: 1-222/290
Sequence Identity: 29% (65 aa)

FSKHLGTGGFGSVYEGVLRDGKKLAVKKLH-SNKGQKQ----FIAEVASLGTIS-HVNIVRLCGFCA----ELSHRLLVYEFMPNGSLDKWIFR------
|.. .|.||.|.|| |. | |.. |.|..|  ..  ..    |. ||  . ..  | |||.. |.|.      ... .| |..| |||.. . .      
FWNKIGEGGYGQVYKGKWR-GYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

--NQEAPLDWDRRYSIALGTARGLAYLHEESREPIIHLDIKPQNILLDEN-----FEAKVGDFGMAKLLMSRDVTQVI-------TGVRGTPGYLAPEWL
  |.. .|.. .|...|.  |.|. ||| ..   |||.|.|..|.|.|.|     . .|. ||| .|.. ... . ..       ... |.. ..||| |
NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVL

LS--NTATKKCDVYSYGMVLLELI
 .  .. ..|.||||.|.|| |..
RMNFCQYSEKSDVYSFGIVLWEIA
Kinase IRAKm_e.AA Dicty4 545-736 32 6e-46 151.32 In-house 2-210 (277) Show / Hide 
Range on Protein: 545-736
Range on HMM: 2-210/277
Sequence Identity: 32% (70 aa)

AFSKHLGTGGFGSVYEGVLRDGKKLAVKKLHSNKGQ------KQFIAEVASLGTISHVNIVRLCGFCA----ELSHRLLVYEFMPNGSLDKWIFRN----
.. . .|.|.||.|| |  | ||. ||||| ...        . | .||. .. |.| ||. . | |     . .  . | |.|| |.| . . ..    
NIEQRIGKGSFGEVYKGTWR-GKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYS-LLHDKPSE

--QEAPLDWDRRYS---IALGTARGLAYLHE-ESREPIIHLDIKPQNILLDENFEAKVGDFGMAK-LLMSRDVTQVITGVRGTPGYLAPEWLLSNTATKK
  |. .||| .. .   .|. .|||...||.  ..  |||.|.|. |.| |.|. .||.||| ..      | ..  ... |||.. ||| . ..  . |
QQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV--IIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEK

CDVYSYGMVLLEL
 ||||.|.|| |.
ADVYSFGIVLWEI
Kinase IRAKm_e.AA MLK 544-737 30 2.1e-45 155.47 In-house 1-230 (291) Show / Hide 
Range on Protein: 544-737
Range on HMM: 1-230/291
Sequence Identity: 30% (72 aa)

KAFSKHLGTGGFGSVYEGVLRDGKK-----LAVKKLHSNK--------GQKQFIAEVASLGTISHVN----IVRLCGFCAEL-SHRLLVYEFMPNGSLDK
  |....| |.||.|. |. | .|      .|||. ....         |..|  |.  |  .|| |    |... | |..  .| ..| |....|||  
IQFHEWIGSGSFGKVWKGRWR-NKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

WI--FRNQEA----------PLDWDRRYSIALGTARGLAYLHEESREPIIHLDIKPQNILLDE------NFEAKVGDFGMAKLLMSRDVTQV---ITGVR
 .   |....            | |   ..||  |||..|||.. . |||| |.|..|||.||      .  .|. |||      |||..|     .. .
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFG-----TSRDWHQMCTNMMSNA

GTPGYLAPEWL---LSNTATKKCDVYSYGMVLLELI
||. . ||| .    ... ..||||.|.|.|| |..
GTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEML
Kinase IRAKm_e.AA Dicty4-Unclassified 545-739 35 5.8e-44 148.44 In-house 2-204 (263) Show / Hide 
Range on Protein: 545-739
Range on HMM: 2-204/263
Sequence Identity: 35% (75 aa)

AFSKHLGTGGFGSVYEGVLRDGKKLAVKKLHSNKGQKQ------FIAEVASLGTISHVNIVRLCGFCAEL-SHR---LLVYEFMPNGSLDKWIF---RNQ
   . .| | |  |. |. . ||  ||||. .|| .        | .||. || |.| | |.. | |    ||.     | |||. | |   |      |
QIDQFIGKGHFSKVHKGNWK-GKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQ

EAPLDWDR--RYSIALGTARGLAYLHEESREPIIHLDIKPQNILLDENFEAKVGDFGMAKLLMSRDVTQVITGVRGTPGYLAPEWLLSNTATKKCDVYSY
. |.  |      .|.  |.|...||  .|. .|| |||  |||.| .| .|..|||..      | ..  | . |||   .|| |     . | |||||
QQPIKLDDTLIIKYAFDIAQGMQHLH--TRN-FIHRDIKSSNILMDKHFNIKIADFGISRVI---DFNFNMTTIAGTPKWESPECLMHESYNQKSDVYSY

GMVLLELIGG
.|.| ||. |
AMMLYELATG
Kinase IRAKm_e.AA LISK 549-741 30 3.5e-37 118.23 In-house 1-237 (296) Show / Hide 
Range on Protein: 549-741
Range on HMM: 1-237/296
Sequence Identity: 30% (72 aa)

HLGTGGFGSVYEGVLR-DGKKLAVKKLH-------SNKGQKQFIAEVASLGTISHVNIVRLCGFCAE-LSHRLLVYEFMPNGSLDKWIFRN--QEAPLDW
 .| |.||.|| | .| .|.  |.|..|        .  || .. ||. .  ..| |||.  | | .  ..  .| |..  | |   ....  .  || |
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW

DRRYSIALGTARGLAYLHEESREPIIHLDIKPQNILLDEN----FEAKVGDFGMAKLLMSRD---------------------VTQVITGV-----R---
. | .|||. |.|..|||.     ||| | | .|.|..||    ...||.||| |...  ..                         | .      .   
PQRVKIALDIACGMSYLHSMN---IIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESDPCMDNDMPMKRKIPKKCMNQRKRRM

---GTPGYLAPEWLLSNTATKKCDVYSYGMVLLELIGGRK
   |||   ||| ||    . .|||.|.|.||.|.|...|
TICGTPYWMAPEMLLGQSYDESCDVFSFGIVLCEIITRVK
Kinase IRAKm_e.AA S_TKc 544-814 23 5.4e-37 130.14 SMART 1-231 (231) Show / Hide 
Range on Protein: 544-814
Range on HMM: 1-231/231
Sequence Identity: 23% (69 aa)

KAFSKHLGTGGFGSVYEGVLRD-GKKLAVKKLHSNKGQKQFIAEVASLGTISHVNIVRLCGFCAELSHRLLVYEFMPN--GSLDKWIFRNQEAP----LD
  . ...| |.||.|| .. .. |.. |.|...     .... |.. |    | |||.| ... . .|  .| |....  |.| . | ...  .    ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP

WDRRYSIALGTARGLAYLHEESREPIIHLDIKPQNILLDENFEAKVGDFGMAKLLMSRDVTQVITGVRGTPGYLAPEWLLSNTATK-KCDVYSYGMVLLE
  .  ...  ....|.|.|.     ||| |.||.||||||  . |..|||.|..|         | . ||| |.||| |     .| |||..| | .| |
E-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

LIGGRKNLDPAKIDSELSFFFPAWAVNEVKQGRLLSVVDPKIRDGVDNQGAERMVKVAFWCIQENPADRPTMDAVIQ---------ML
.. |.   .    . .. |                                . .      | | .|..|||   . |          .
MLCGYPPFP----QMQMMFKKIG---------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAKm_e.AA LRRK 544-737 25 4.8e-36 125.01 In-house 1-276 (351) Show / Hide 
Range on Protein: 544-737
Range on HMM: 1-276/351
Sequence Identity: 25% (71 aa)

KAFSKHLGTGGFG-SVYEGVLRD---------------------------GKKLAVKKLHSN------------------------------------KG
  . . .| |||| .|| . .|.                           ... |.||..                                      . 
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

QKQFIAEVASLGTISHVNIVRLCGFCAELSHRLLVYEFMPNGSLDKWIFRNQEAP-------LDWDRRYSIALGTARGLAYLHEESRE-PIIHLDIKPQN
   |  ||. . .  | ||| | |||  .... .| |..|.|.|.. .. ... .       ..|  .. |||  |.|..|||  |.  |||| | |. |
FREFRHEVWIMSHLNHPNIVSLKGFC--IHPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLH--SHNPPIIHRDLKSPN

ILL---D---------ENFEAKVGDFGMAKLLMSRDVTQVITGVRGTPGYLAPEWLLSN---TATKKCDVYSYGMVLLELI
|||   .         ..  ||..|||    . . . . |. |. |.||..||| .  |   . | | |.||.||.| ||.
ILLWSSPQNHSPNYPNAHVCAKIADFGISR-MFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELL
Kinase IRAKm_e.AA RIPK 550-741 28 3.4e-35 117.36 In-house 1-226 (290) Show / Hide 
Range on Protein: 550-741
Range on HMM: 1-226/290
Sequence Identity: 28% (66 aa)

LGTGGFGSVYEGVLRDGKKLAVKKLHSNKG---------QKQFIAEVASLGTISHVNIVRLCGFCAEL-----SH-RLLVYEFMPNGSLDKWIFRNQEA-
.| |||| |.  . |. .  ..||    |          ... . |.. .  . . .||.. ||| .      .    .| |.|.||||  | |.  .  
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSL--WHFLHTKWP

----PLDWDRRYSIALGTARGLAYLHEESRE-PIIHLDIKPQNILLDENFEAKVGDFGMAKLLMSRDVTQ---------VITGVR--GTPGYLAPEWLL-
    |. |. |  .   ...|  |||  |   ||||.| ||.|||.| || .|. ||| |. .|   ..|           ..    ||  |..|| .. 
YQHHPDPWPLRCRMIHEISCGMCYLH--SMNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRT

--SNT---ATKKCDVYSYGMVLLELIGGRK
  ..    .|.| ||||...|. |.  ...
DNKKPIKVVTPKYDVYSFAIVMWEVLTQKH
Kinase IRAKm_e.AA Pkinase_Tyr 545-737 29 5.9e-33 112.24 Pfam 2-208 (270) Show / Hide 
Range on Protein: 545-737
Range on HMM: 2-208/270
Sequence Identity: 29% (61 aa)

AFSKHLGTGGFGSVYEGVLR-----DGKKLAVKKL--HSNKGQ---KQFIAEVASLGTI-SHVNIVRLCGFCA-ELSH--RLLVYEFMPNGSLDKWIFRN
 | | || | ||.||.|...     .. . |||.|  .. . |   . |..|.. . .. .| ||||| | |  .  .   ..| |.||.|.|..   ..
TFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKH

--QEAPLDWDRRYSIALGTARGLAYLHEESREPIIHLDIKPQNILLDENFEAKVGDFGMAKLLMSRDVT-QVITGVRGTPGYLAPEWLLSNTATKKCDVY
  .. ||.  .  ....  |.|..||..     .|| |.   |.|..||. .|..|||.|..... |   .. .| .     .||| .  .  | | ||.
REDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVW

SYGMVLLELI
|.| .. |..
SFGVLMWEIF
Kinase IRAKm_e.AA DRK 545-737 32 3.3e-32 106.41 In-house 2-196 (258) Show / Hide 
Range on Protein: 545-737
Range on HMM: 2-196/258
Sequence Identity: 32% (64 aa)

AFSKHLGTGGFGSVYEGVLRDGKKLAVKKLHSNKGQ-----KQFIAEVASLGTISHVNIVRLCGFCAELSHRLLVYEFMPNGSLDKWIFRNQEAPLDWDR
.     | |..| |. |  | | . |||.|           . |  |.  .    | ||.   | | . .  . . |.|| ||| . |  ..   .|| .
KIGNRIGRGNYGEVFRGTWR-GTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYN-ILHDESIEMDWPL

RYSIALGTARGLAYLHEESREPII-HLDIKPQNILLDENFEAKVGDFGMAK-LLMSRDVTQVITGVRGTPGYLAPEWLLSNTATKKCDVYSYGMVLLELI
. ....  |.|. |||  ...||| | | |  | | ||..  || ||| .      .. .   | . |||.  ||| | .   | | ||||.. || |..
MKQMMFDCAKGMIYLH--CCNPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQHKFAMTMC-GTPCWTAPEVLRNQRYTEKADVYSFAIVLWECV
Kinase IRAKm_e.AA TyrKc 544-814 24 8.4e-29 102.93 SMART 1-280 (280) Show / Hide 
Range on Protein: 544-814
Range on HMM: 1-280/280
Sequence Identity: 24% (72 aa)

KAFSKHLGTGGFGSVYEGVLRDGKKLAVKKLHSNKGQKQFIAEVASLGTI--SHVNIVRLCGFCAEL-------SHRLLVYEFMPNGSLDKWIFRNQEAP
  . | || | || ||.|...   . |||.|.... .. |. |   .  .  .| ||||| | | .           ..| |.||.|.|.. . ....  
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK-

LDWDRRYSIALGTARGLAYLHEESREPIIHLDIKPQNILLDENFEAKVGDFGMAKLLMSR-------DVTQVIT--GVR--GTPGYLAPEWLLSNTATKK
| ..   |...  |.| .|||.    ..|| |.   |.|..||. .|..|||... . .        |.  . .  | .       .||| .  .. | |
LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTK

CDVYSYGMVLLELI--GGRKNLDPAKIDSELSFFFPAWAVNEVKQGRLLSVVDPKIRDGVDNQ----GAERMVKVAFWCIQENPADRPTMDAVIQML
 ||.|.| .. |.   |.    ....      .  .. ... ||||. .   .                . | ..  .| .|.|.||||. .... .
SDVWSFGVCMWEIFTYGQQPYPGMIQQ-----MMSNQEVIEYVKQGYRMPQPPNDY----P-MSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase IRAKm_e.AA Dicty4-Unclassified 775-814 42 2e-06 17.81 In-house 228-263 (263) Show / Hide 
Range on Protein: 775-814
Range on HMM: 228-263/263
Sequence Identity: 42% (17 aa)

PKIRDGVDNQGAERMVKVAFWCIQENPADRPTMDAVIQML
||| | .||     . |   ||  . |  ||||. .|| |
PKIPDNCDNF----WKKLIKWCWHNDPNKRPTMNQIIQYL
Kinase IRAKm_e.AA DRK 796-816 38 5.1e-05 12.97 In-house 238-258 (258) Show / Hide 
Range on Protein: 796-816
Range on HMM: 238-258/258
Sequence Identity: 38% (8 aa)

CIQENPADRPTMDAVIQMLEG
|  |.|  ||.|. ... || 
CWNEDPQHRPSMQECLERLEA
Kinase IRAKm_e.AA MLK 796-814 31 0.000691 9.52 In-house 273-291 (291) Show / Hide 
Range on Protein: 796-814
Range on HMM: 273-291/291
Sequence Identity: 31% (6 aa)

CIQENPADRPTMDAVIQML
| ...|..||... ..| |
CWNQDPHKRPSFRQIVQHL
Kinase IRAKm_e.AA Pkinase_Tyr 796-814 36 0.001126 13.07 Pfam 252-270 (270) Show / Hide 
Range on Protein: 796-814
Range on HMM: 252-270/270
Sequence Identity: 36% (7 aa)

CIQENPADRPTMDAVIQML
| ...|.||||. .....|
CWHYDPEDRPTFSEIHEQL
Kinase IRAKm_e.AA Dicty4 795-816 37 0.0017 7.72 In-house 254-277 (277) Show / Hide 
Range on Protein: 795-816
Range on HMM: 254-277/277
Sequence Identity: 37% (9 aa)

WCIQENPADRPTMDAVIQM--LEG
||  ..|  ||..  .||   || 
WCWDHDPQHRPSFEEIIQRRILEH
Kinase IRAKm_e.AA LISK 790-814 28 0.006517 5.07 In-house 272-296 (296) Show / Hide 
Range on Protein: 790-814
Range on HMM: 272-296/296
Sequence Identity: 28% (7 aa)

VKVAFWCIQENPADRPTMDAVIQML
....|.|.  .| .||. . ..| |
LDLCFDCCKYDPKNRPSFKEIVQWL
Kinase IRAKm_e.AA LRRK 795-816 27 0.020443 4.34 In-house 330-351 (351) Show / Hide 
Range on Protein: 795-816
Range on HMM: 330-351/351
Sequence Identity: 27% (6 aa)

WCIQENPADRPTMDAVIQMLEG
.| |..| .||..  ... |. 
HCWQHDPKKRPHFSQIVKRLSQ
Kinase IRAKm_e.AA TKL-Unique 796-814 36 0.033998 3.76 In-house 272-290 (290) Show / Hide 
Range on Protein: 796-814
Range on HMM: 272-290/290
Sequence Identity: 36% (7 aa)

CIQENPADRPTMDAVIQML
|   .| .||. | .|  |
CWHHDPSQRPSFDEIIHRL
Kinase IRAKm_e.AA IRAK 780-814 22 0.087302 2.31 In-house 283-317 (317) Show / Hide 
Range on Protein: 780-814
Range on HMM: 283-317/317
Sequence Identity: 22% (8 aa)

GVDNQGAERMVKVAFWCIQENPADRPTMDAVIQML
..... .. |  .|  |  .  . |..|. | | |
PCPPNMEKEMCQCACCCGHHRANRRCDMAWVMQQL
Kinase IRAKm_e.AA Pkinase 795-814 31 2.242523 2.41 Pfam 272-293 (293) Show / Hide 
Range on Protein: 795-814
Range on HMM: 272-293/293
Sequence Identity: 31% (7 aa)

WCIQENPADRPTMDAVIQM--L
||.. .|..||| . . |   .
WCLCKDPKKRPTAEQILQHPWF