Gene IRAKm_r-2 (S.moellendorffii)

IRAKm_r-2

Species: S.moellendorffii
Alias: IRAKm_r-2
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAKm

Sequence

Name Sequence Type Origin Length Description Download
IRAKm_r-2.AA Protein None 258 None Fasta, JSON
IRAKm_r-2.NA RNA None 774 None Fasta, JSON
IRAKm_r-2.kin_dom Protein Kinase Domain None 145 None Fasta, JSON

Protein domain

Protein domains of IRAKm_r-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IRAKm_r-2.AA TKL 85-230 25 1.4e-29 103.63 In-house 86-287 (364) Show / Hide 
Range on Protein: 85-230
Range on HMM: 86-287/364
Sequence Identity: 25% (54 aa)

NIVKLCGFCIEGAT------------QWLLVYEFMPNGSLDKWLFEQTSENVWLSWQKRIDIALGTTQGLAYLHE----ECREP--ILHLD--SP*ILLD
|||.. |.|...              |  .|.|..|.|||   |           |..|...||.. .|..|||      |. .  |.| |  |. ||.|
NIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCT-KPPIIHRDLKSKNILVD

TEFV--------------AKVADFGMAKLLE---NCNETQVMTI--------------IGGTPGYMAPEWLT----------------HFMATKRCDVYS
  .               .|..||| .. ..   | | |. ..               ..|||..|||| |                 .| ....|||||
ENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYS

YEKVLLELIEGRR
.  || |.. ..|
FGIVLWEILTRCR
Kinase IRAKm_r-2.AA IRAK 85-233 38 4e-25 86.06 In-house 64-225 (317) Show / Hide 
Range on Protein: 85-233
Range on HMM: 64-225/317
Sequence Identity: 38% (62 aa)

NIVKLCGFCIEGATQWLLVYEFMPNGSLDKWLFEQTSENVW--LSWQKRIDIALGTTQGLAYLHEEC-REPILHLD--SP*ILLDTEFVAKVADFGMAKL
||| | |.|.|.  .  |||..||||||   |  |.  .    |||..|..|..||  |. .||.     || | |  |  ||||  |..| .|||..  
NIVPLYGYCTERQ-CHCLVYPYMPNGSLEDRLWCQDGQCPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRF

L---ENCNETQV---MT-IIGGTPGYMAPEWLT--HFMATKRCDVYSYEKVLLELIEGRRNID
    ..   . .   || .. ||  ||.|| ..      ||. ||||   ||||.. |.|  .
GHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQLTKKTDVYSFGIVLLEVLTGCRAVY
Kinase IRAKm_r-2.AA TKL-Unique 84-228 27 6e-23 77.87 In-house 56-224 (290) Show / Hide 
Range on Protein: 84-228
Range on HMM: 56-224/290
Sequence Identity: 27% (47 aa)

INIVKLCGFCIE---GATQWLLVYEFMPNGSLDKWLF------EQTSENVWLSWQKRIDIALGTTQGLAYLHEECREPILHLD--SP*ILLDTE-----F
.|||.. |.|.     . .. .| |..| |||.. |          ..|  |..|.|...|.   ||. ||| .    |.|.|  |. .|.| .     .
PNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEW

VAKVADFGMAKLLENCNETQVMTI-------IGGTPGYMAPEWLTH--FMATKRCDVYSYEKVLLELIEG
 .|..||| .|.. . |.. . ..         |.. .|||| |.   .. .. .||||.  || |....
NIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATR
Kinase IRAKm_r-2.AA Dicty4-Unclassified 55-228 32 8.9e-22 71.33 In-house 22-204 (263) Show / Hide 
Range on Protein: 55-228
Range on HMM: 22-204/263
Sequence Identity: 32% (62 aa)

GRVVAVKKLDYSGTQGAK-----*FVTEIAGTGGI---NIVKLCGFCIEG---ATQWLLVYEFMPNGSLDKWLFEQTSE-NVWLSWQK--RIDIALGTTQ
|. |||||.  ..   .       |  |..  | |   | ||. | ||           | |||. | |      . || .  ..      | .|.   |
GKDVAVKKFN-ENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQPIKLDDTLIIKYAFDIAQ

GLAYLHEECREPILHLD--SP*ILLDTEFVAKVADFGMAKLLENCNETQVMTIIGGTPGYMAPEWLTHFMATKRCDVYSYEKVLLELIEG
|...||   |. . | |  |  ||.|  | .|.||||..   ..   .. || |.|||   .|| | |   . . |||||  .| ||. |
GMQHLH--TRN-FIHRDIKSSNILMDKHFNIKIADFGISRVIDF---NFNMTTIAGTPKWESPECLMHESYNQKSDVYSYAMMLYELATG
Pkinase IRAKm_r-2.AA Pkinase 53-229 24 4.9e-21 75.46 Pfam 22-209 (293) Show / Hide 
Range on Protein: 53-229
Range on HMM: 22-209/293
Sequence Identity: 24% (49 aa)

SDGRVVAVKKLDYSGTQGAK*FVT-----EIAGTGGI---NIVKLCGFCIEGATQWLLVYEFMPNG----SLDKWLFEQTSENVWL--SWQKRIDIALGT
..|..||||..... ..  .  .|     ||.    .   |||.| ... ..   . .| |....|    .|  ..    ... ..  |..  ..... .
GTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIY-MVMEYCEGGLYVMDLFDYIST--WRHGCFYFSEWECKFYMYQI

TQGLAYLHEECREPILHLD--SP*ILLDTEFVA----KVADFGMAKLLENCNETQVMTIIGGTPGYMAPEWLT-HFMATKRCDVYSYEKVLLELIEGR
 .||.|.|..    |.| |  .  ||.| . .     |..||| ||...     . || . |||.|||||..  . . ....|..|.  .| |.. ||
LRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGR
Kinase IRAKm_r-2.AA MLK 85-218 25 4.4e-16 52.4 In-house 66-222 (291) Show / Hide 
Range on Protein: 85-218
Range on HMM: 66-222/291
Sequence Identity: 25% (41 aa)

N----IVKLCGFCIEGATQWLLVYEFMPNGSLDKWLFEQTS----------ENVWLSWQKRIDIALGTTQGLAYLHEECREPILH--LDSP*ILLD----
|    |... | |..   . ..| |....|||   | ...|            .  . .  ...||   .|..|||.. . || |  | |. ||.|    
NNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICH

--TEFVAKVADFGMAK-LLENCNETQVMTIIGGTPGYMAPEWL---THFMATKRCDVYSY
   . ..|..||| .. . ..| ..  |.   ||. .|||| .    . . .. |||.|.
DMHHGTLKICDFGTSRDWHQMC-TN--MMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSW
Kinase IRAKm_r-2.AA Dicty4 105-218 29 4.7e-15 46.83 In-house 82-203 (277) Show / Hide 
Range on Protein: 105-218
Range on HMM: 82-203/277
Sequence Identity: 29% (37 aa)

EFMPNGSLDKWLFE---QTSENVWLSWQKRID---IALGTTQGLAYLHE-ECREPILHLD--SP*ILLDTEFVAKVADFGMAK-LLENCNETQ-VMTIIG
|.|| |.| . |        ... |.|  ..    .|. . .|...||.  ..  |.|.|  |  .| |  ...||.||| ..   .  . ..  || . 
EYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV--IIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTAC-

GTPGYMAPEWLTHFMATKRCDVYSY
|||..|||| . |   .   ||||.
GTPCWMAPEVMMHQPYNEKADVYSF
Kinase IRAKm_r-2.AA RIPK 85-229 28 4.8e-15 47.69 In-house 57-225 (290) Show / Hide 
Range on Protein: 85-229
Range on HMM: 57-225/290
Sequence Identity: 28% (48 aa)

NIVKLCGFCIEG--ATQWL---LVYEFMPNGSLDKWLFEQTS-ENVWLSWQKRIDIALGTTQGLAYLHEECRE-PILHLD--SP*ILLDTEFVAKVADFG
.||.. |||..   . .     .| |.|.|||| . |  ...  .  . |  |  .   .  |  |||  .   ||.|.|     ||.| .| .|.||||
HIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQHHPDPWPLRCRMIHEISCGMCYLH--SMNPPIIHRDLKPENILVDNNFHVKIADFG

MAKLLENCNETQ-------VMT----IIGGTPGYMAPEWLT--HFMA----TKRCDVYSYEKVLLELIEGR
 |. ..    .|       |        .||  ||.|| .      .    |.  ||||.  |. |.  ..
LATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDNKKPIKVVTPKYDVYSFAIVMWEVLTQK
Kinase IRAKm_r-2.AA LISK 126-226 29 1.1e-14 44.0 In-house 98-233 (296) Show / Hide 
Range on Protein: 126-226
Range on HMM: 98-233/296
Sequence Identity: 29% (41 aa)

LSWQKRIDIALGTTQGLAYLHEECREPILH--LDSP*ILLDTE----FVAKVADFGMAKLLENCNET---------------------------------
|.|..|..|||.  .|..|||. .   |.|  | |  .|...     . .||.||| |....  |                                   
LPWPQRVKIALDIACGMSYLHSMN---IIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESDPCMDNDMPMKRKIPKKCMNQRK

QVMTIIGGTPGYMAPEWLTHFMATKRCDVYSYEKVLLELI
. |||  |||  |||| |.    . .|||.|.  ||.|.|
RRMTIC-GTPYWMAPEMLLGQSYDESCDVFSFGIVLCEII
Kinase IRAKm_r-2.AA HH498 85-229 25 8.4e-14 39.74 In-house 63-223 (284) Show / Hide 
Range on Protein: 85-229
Range on HMM: 63-223/284
Sequence Identity: 25% (41 aa)

NIVKLCGFCIEGATQWLLVYEFMPNGSLDKWL--------------FEQTSENVWLSWQKRIDIALGTTQGLAYLHEECREPILH--LDSP*ILLDTEFV
. |.  . |..   | ..| ..  ||||   |               .|      .. | .  |..   .|  |||.    || |  | |  ||.. .  
CVVQFVYACCDDPSQFAIVTQYCDNGSLFSILNTIPIGGAGANNNNHNQKNNYRIMDLQSKMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIHEDGH

AKVADFGMAKLLENCNETQVMTIIGGTPGYMAPEWLT-HFMATKRCDVYSYEKVLLELIEGR
|.|||||    ..   .   ||   | . .||||  .     ..  ||.||  .. |.  ..
AVVADFGESRFVCDMHD-DNMTKQPGNLRWMAPEVFSQCQKYSIKVDVFSYAMCIWEMHTRE
S_TKc IRAKm_r-2.AA S_TKc 44-252 20 1.2e-09 -35.28 SMART 1-231 (231) Show / Hide 
Range on Protein: 44-252
Range on HMM: 1-231/231
Sequence Identity: 20% (54 aa)

WDLLQI-----------GVLSD-GRVVAVKKLDYSGTQGAK*FVTEIA---GTGGINIVKLCGFCIEGATQWLLVYEFMPN--GSLDKWLFEQTSEN--V
...|..           ..  . ||.||.|...       . .  ||.     .  ||||| ... .  .   .| |....  |.| . . .. ..   .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

WLSWQKRIDIALGTTQGLAYLHEECREPILHLD--SP*ILLDTEFVAKVADFGMAKLLENCNETQVMTIIGGTPGYMAPEWLTHFMATK-RCDVYSYEKV
...      ..  . ..|.|.|.     |.| |     ||||.  . |..|||.|..|         | . ||| ||||| |     .| .||..|   .
PFPE-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI

LLELIEGRR----NIDLSKAVNSGDNTQ----------PE--------E-------SRFF
| |.. |.        . | .   .             ||        .         .|
LYEMLCGYPPFPQMQMMFKKIG-SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
TyrKc IRAKm_r-2.AA TyrKc 48-252 17 2.5e-09 -71.71 SMART 16-280 (280) Show / Hide 
Range on Protein: 48-252
Range on HMM: 16-280/280
Sequence Identity: 17% (48 aa)

QIGVLSDGRVVAVKKLD-YSGTQGAK*FVTEIAGTGGI-----NIVKLCGFCIEGA------TQWLLVYEFMPNGSLDKWLFEQTSENVWLSWQKRIDIA
  |...  . ||||.|  ..     . |  |.     .     |||.| | |...        . ..| |.||.|.|.. | .   .   |.... ....
YKGTWK--IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK---LCMKDLLSFC

LGTTQGLAYLHEECREPILHLD--SP*ILLDTEFVAKVADFGMAKLLENC----NETQVMTIIG--GTPG-----YMAPEWLTHFMATKRCDVYSYEKVL
.   .| .|||.    .. | |     .|.. ....|..|||... ...      .... .  .  |. .      |||| . . . |   ||.|.  ..
WQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCM

LELI-------EG-----RRNIDLSKAVNSGDNTQPEES-----------------------------------RFF
 |.        .|       |... . | .|.   . ..                                   ..|
WEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase IRAKm_r-2.AA TK-Unique 161-218 37 4.9e-08 23.92 In-house 164-225 (294) Show / Hide 
Range on Protein: 161-218
Range on HMM: 164-225/294
Sequence Identity: 37% (23 aa)

ILLDTEFVAKVADFGMAKLLENCNETQVMTIIGGTPG-YMAPEWLT--HFMA-TKRCDVYSY
.||   .|.|..|||||. ... .... |.  | .|  .|||| |   | |. | . ||.|.
VLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSF
Kinase IRAKm_r-2.AA TK-Unique 84-116 33 5.7e-07 20.2 In-house 64-96 (294) Show / Hide 
Range on Protein: 84-116
Range on HMM: 64-96/294
Sequence Identity: 33% (11 aa)

INIVKLCGFCIEGATQWLLVYEFMPNGSLDKWL
.|||...| |..   .|....|..|.|.|.. |
PNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYL
Kinase IRAKm_r-2.AA Pkinase_Tyr 85-147 29 1e-05 20.04 Pfam 65-129 (270) Show / Hide 
Range on Protein: 85-147
Range on HMM: 65-129/270
Sequence Identity: 29% (19 aa)

NIVKLCGFCI-EGAT-QWLLVYEFMPNGSLDKWLFEQTSENVWLSWQKRIDIALGTTQGLAYLHE
|||.| | |. .|   |...| |.||.|.|.. | .. ...  |. .  .....   .|..||..
NIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLES
Kinase IRAKm_r-2.AA Pkinase_Tyr 161-182 36 0.002976 11.64 Pfam 142-163 (270) Show / Hide 
Range on Protein: 161-182
Range on HMM: 142-163/270
Sequence Identity: 36% (8 aa)

ILLDTEFVAKVADFGMAKLLEN
.|.. ..|.|..|||.|....|
CLVTENNVVKICDFGLARDIYN