Gene LLEC_h-2 (S.moellendorffii)

LLEC_h-2

Species: S.moellendorffii
Alias: LLEC_h-2
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: LLEC

Sequence

Name Sequence Type Origin Length Description Download
LLEC_h-2.AA Protein None 538 None Fasta, JSON
LLEC_h-2.NA RNA None 1617 None Fasta, JSON
LLEC_h-2.kin_dom Protein Kinase Domain None 207 None Fasta, JSON

Protein domain

Protein domains of LLEC_h-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase LLEC_h-2.AA TKL 217-487 21 6.7e-61 208.63 In-house 1-364 (364) Show / Hide 
Range on Protein: 217-487
Range on HMM: 1-364/364
Sequence Identity: 21% (84 aa)

LGRGGTSTVYKGFLQN------TPTSRIEVAVKDLQSNSPDHEAE-------------------------QQFREELNMISRVRHQNLVALQGWCHEHDK
.|.|| ..|||| ...      .  .  .|||| . |.. | . .                         ....||..|.|| ||.|.| . | | . ..
IGSGGFGEVYKGKWRGWGGKCPS-DTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPC

-------------LLLVYECMSKGS-LDKVLFTSASGSTNPLSWNQRFNIIRCVAEALRYLHE-----GLEK-RIVHRDIKAANVLLDERMT--------
             | .|.| ...|| |. ..            |.||..... .| .. |||      .  |  |.|||.| .|.|.|| .|        
GCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------------WHQRCRWALDIARGMNYLHSMNPKWCT-KPPIIHRDLKSKNILVDENWTNVSNYMYN

------AKVGDFGLARLMQHTIG------------------SQTMTRAGTFGYISPELAY----------------SGRATEKSDVYSFGILVLEIVAGR
      .|..||||.| |... .                  ..|||. ||... .||.                  .. ..||.|||||||.  ||....
PNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRC

RAVDHRFAGDTKMVLLEWAGTVSQPAELVDPRIQDGIDMKQVER------------------------IIQLALRCCSWHSEERPTMRLCCQIL
|                ...  . | .. || ... . |  ...                        ...|. .|..   |.||..  . ..|
R---------------PYYDYPYMPMIFQDP-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase LLEC_h-2.AA IRAK 213-487 29 1.3e-49 171.1 In-house 1-317 (317) Show / Hide 
Range on Protein: 213-487
Range on HMM: 1-317/317
Sequence Identity: 29% (97 aa)

FKE--VLGRGGTSTVYKGFLQNTP-TSRIEVAVK--DLQSNSPDHEAEQQFRE---ELNMISRVRHQNLVALQGWCHEHDKLLLVYECMSKGSLDKVLFT
| .  ..| ||  .||.| ..||. .    .|||      ..   | .|.|.    ||   .| || |.|.| | | | ... |||. |. |||   |  
FHKDNRIGEGGFGCVYRGQWKNTTGI----YAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWC

SASGST-NPLSWNQRFNIIRCVAEALRYLHEGLEKR----IVHRDIKAANVLLDERMTAKVGDFGLAR-------LMQHTI-GSQTMTRAGTFGYISPEL
 .   .  |||| ||. |    | ....||   ...    | |.||| ||.|||...|.| .||||.|       . ..|.    | .  ||  |  || 
QDGQCPPKPLSWHQRCSICWGTACGIQFLH---QNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEF

AY--SGRATEKSDVYSFGILVLEIVAGRRAVDHRFAG-----DTKMVLLEWAGT--VSQP--------------------AELVDPRIQDGIDMKQVERI
 .  .|. | |.||||||| .||...|.|||. . .      | .... | .|     |.                      ..|.|. .  . . .. .
IRDPQGQLTKKTDVYSFGIVLLEVLTGCRAVYDDRPEHYYLKDLCEEIMEEWGHLDSCQSTLWVGVATDAWAAPRRMQIYEKFIDHRMPP-CPPNMEKEM

IQLALRCCSWHSEERPTMRLCCQIL
 |.|..|      .|..|.   | |
CQCACCCGHHRANRRCDMAWVMQQL
Pkinase LLEC_h-2.AA Pkinase 211-417 26 3.9e-48 171.02 Pfam 1-209 (293) Show / Hide 
Range on Protein: 211-417
Range on HMM: 1-209/293
Sequence Identity: 26% (58 aa)

ADFKEVLGRGGTSTVYKGFLQNTPTSRIEVAVKDLQSNSPDHEAEQQFRE--ELNMISRVRHQNLVALQGWCHEHDKLLLVYECMSKG----SLDKVLFT
  .....|.|. ..|||.  ..|.    .|||| .   . ... .|. |   |. .  |..| | | | .|....|.. .| |.. .|    .|  .. |
YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

SASGSTNPLSWNQRFNIIRCVAEALRYLHEGLEKRIVHRDIKAANVLLDERMTA----KVGDFGLARLMQHTIGSQTMTRAGTFGYISPELAY-SGRATE
...|.   .|...  .... ....| |.|.    .|.|||.| .|.|.|....     |..|||||.....  .| ..|..|| .|..||.   .   . 
WRHGCFY-FSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGP

KSDVYSFGILVLEIVAGR
|.|..|.|... | . ||
KVDMWSCGCILYEMLCGR
Kinase LLEC_h-2.AA TKL-Unique 213-414 29 1.3e-41 144.5 In-house 1-222 (290) Show / Hide 
Range on Protein: 213-414
Range on HMM: 1-222/290
Sequence Identity: 29% (67 aa)

FKEVLGRGGTSTVYKGFLQNTPTSRIEVAVKDLQ-SNSPDHEAEQQFREELNMISRVR-HQNLVALQGWCH----EHDKLLLVYECMSKGSLDKVLFTSA
| ...|.|| ..||||        ...||.| .   ...  | .| |..|.| ... . | |.| . |.|.       .. .| |... |||..|| .. 
FWNKIGEGGYGQVYKGKWR-----GYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNN

SGS-----TNPLSWNQRFNIIRCVAEALRYLHEGLEKRIVHRDIKAANVLLDER-----MTAKVGDFGLARLMQHTIGSQTM--------TRAGTFGYIS
  .      ..|...|| ......| .. |||  .|. | |||.|  |.|.|..     . .|. ||||...    . . .         || |.| ...
NNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLH-HCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMA

PELAYS--GRATEKSDVYSFGILVLEIV
||.  .     .|||||||||| . ||.
PEVLRMNFCQYSEKSDVYSFGIVLWEIA
Kinase LLEC_h-2.AA MLK 211-417 25 9.5e-40 135.59 In-house 1-233 (291) Show / Hide 
Range on Protein: 211-417
Range on HMM: 1-233/291
Sequence Identity: 25% (60 aa)

ADFKEVLGRGGTSTVYKGFLQNTPTSRIEVAVKDLQSNSPDHEAE-----QQFREELNMISRVRHQN----LVALQGWCHEHDK-LLLVYECMSKGSLDK
 .|.|..| |.   |.||  .|.  .  .||||   ..     ..     ..|..| .  ....|.|     ... | |... . ...| | ...|||  
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

VLFTSASGST-----NP----LSWNQRFNIIRCVAEALRYLHEGLEKRIVHRDIKAANVLLDE------RMTAKVGDFGLARLMQHTIGSQTMTRAGTFG
|| .  |..      ..     .  . .|.   .|... |||. . | |.|||.|  |.|.||       .|.|. |||..| ....  .  | .|||. 
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYA

YISPEL---AYSGRATEKSDVYSFGILVLEIVAGR
. .||    . ... .||.||.|.|..  |.....
WMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTRE
S_TKc LLEC_h-2.AA S_TKc 211-486 21 4.1e-39 137.18 SMART 1-231 (231) Show / Hide 
Range on Protein: 211-486
Range on HMM: 1-231/231
Sequence Identity: 21% (61 aa)

ADFKEVLGRGGTSTVYKGFLQNTPTSRIEVAVKDLQSNSPDHEAEQQFREELNMISRVRHQNLVALQGWCHEHDKLLLVYECMSK--GSLDKVLFTSASG
 .. ...|.|. ..|||.   .   .  .||.| .          ...| |... .. .| |.| | ..... |.| .| |...   |.| ...    ..
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

STN-PLSWNQRFNIIRCVAEALRYLHEGLEKRIVHRDIKAANVLLDERMTAKVGDFGLARLMQHTIGSQTMTRAGTFGYISPELAYSGRATE-KSDVYSF
 .. |..  .   ... ...|| |.|   ...|.|||.| .|.||||  . |..||||||..        .|  ||  |..||.      .  |.|..|.
GLRFPFPE-HARFYMYQICCALEYCH---SHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSC

GILVLEIVAGRRAVDHRFAGDTKMVLLEWAGTVSQPAELVDPRIQDGIDMKQVERIIQLALRCCSWHSEERPTMRLCCQ----------I
|... | ..|.   .      . .....  |                      .  ...  .|. .  |.|||   . |          .
GCILYEMLCGYPPFP------QMQMMFKKIG---------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase LLEC_h-2.AA TK 211-414 16 7.8e-38 123.88 In-house 1-388 (486) Show / Hide 
Range on Protein: 211-414
Range on HMM: 1-388/486
Sequence Identity: 16% (66 aa)

ADFKEVLGRGGTS---TVYKGFLQNTP----------------------TSRIEVAVKDLQSNSPDHEAEQQ---------------FREELNMIS--RV
  . ..||.|      .|||| ... .                        ...|||| | . ......|..               . ||. | .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHQNLVALQGWCHEHDK------------LLLVYECMSKGS----LDKVLFTSASGSTN-----------------------------------------
.|.|.| | | |....             ...| |.|..|.    |.. | ..  . ..                                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------------------------------PLSWNQRFNIIRCVAEALRYLHEG---LEKRIVHRDIKAANVLLDERMT-----------AKVGDFGLAR
                              .|.  |.  . . .|....|||.    .....||||. | |.|..|...           .|..||||.|
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

L----MQHTIGS-QTMTRAGTFG----------------------------YISPELAY---------SGRATEKSDVYSFGILVLEIV
     .   |.| .  .|... |                            . .||             |. |.||||.|||.|. ||.
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIF
Kinase LLEC_h-2.AA STE 211-417 22 2.1e-36 126.05 In-house 1-265 (359) Show / Hide 
Range on Protein: 211-417
Range on HMM: 1-265/359
Sequence Identity: 22% (63 aa)

ADFKEVLGRGGTSTVYKGFLQNT----PTSRI--------EVAVK--DLQSNSP-------------DHEAEQQFREELNMISRVR--HQNLVALQGWC-
 .. |..|.|.. ||||.   ..    .| ..         .|.|  .|.....             .|| .||. .|... .. .  |.| |   | . 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

HE------HDKLLLVYECMSKGSLDKVLF-TSASGSTNPLSW--------NQRFNIIRCVAEA-LRYLHEGLEKRIVHRDIKAANVLLDERMTAKVGDFG
.|      .|.| .. | |. ||||...  .   | .....         .|   |.| . .. | |||.     |.|||||.||.||     .|  |||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDFG

LARLMQH---------------TIGSQTMTRAGTFGYISPELAYSGR------ATEKSDVYSFGILVLEIVAGR
..  ...               |..... | .||  . .||    ..       ..|.|..|.|....| . |.
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK
Kinase LLEC_h-2.AA LRRK 211-422 22 3.3e-36 125.57 In-house 1-285 (351) Show / Hide 
Range on Protein: 211-422
Range on HMM: 1-285/351
Sequence Identity: 22% (65 aa)

ADFKEVLGRGGTS-TVYKGFLQN-----------------------TPTSRIEVAVKDLQS----------NSPD----------------------HEA
  . | .||||.  .||.. ...                       .  .. .||.| .            || .                      ..|
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

EQQFREELNMISRVRHQNLVALQGWCHEHDKLLLVYECMSKGSLDKVLFTSASGST----NPLSWNQRFNIIRCVAEALRYLHEGLEKR--IVHRDIKAA
 . || |. ..|. .| |.| | | |...  | .| | .. |.|...|. ... .       .||. .  |   .|....|||    ..  |.||| |  
FREFRHEVWIMSHLNHPNIVSLKGFCIHP--LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLH---SHNPPIIHRDLKSP

NVLL---D---------ERMTAKVGDFGLARLMQHTIGSQ-TMTRAGTFGYISPELAYSG---RATEKSDVYSFGILVLEIVAGR-RAVDH
|.||   .         . ..||..|||. | |  ....  ...  |..|. .||    .     |||.|.||||..  |.. .. .. |.
NILLWSSPQNHSPNYPNAHVCAKIADFGISR-MFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDE
Kinase LLEC_h-2.AA Pkinase_Tyr 211-414 29 3.7e-34 116.32 Pfam 1-208 (270) Show / Hide 
Range on Protein: 211-414
Range on HMM: 1-208/270
Sequence Identity: 29% (64 aa)

ADFKEVLGRGGTSTVYKGFLQ-NTPTSRIEVAVKDLQSNSPDHEA--EQQFREELNMISRV-RHQNLVALQGWCH-EHDK--LLLVYECMSKGSLDKVLF
  | ..||.|   .|||| .       .|.|||| |  .. .||.   . | .|... .   .|.|.| | | |  . .   ...| | | .|.|.. | 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

TSASGSTNPLSWNQRFNIIRCVAEALRYLHEGLEKRIVHRDIKAANVLLDERMTAKVGDFGLARLM----QHTIGSQTMTRAGTFGYISPELAYSGRATE
.    . .||.  .  .. . .|... ||.   .|...|||. | |.|..| ...|..||||||..    .  . ... ..   . . .||    |. |.
KHR-EDKQPLTMKDLLQMCWQIAKGMEYLE---SKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWM-APECINYGKFTT

KSDVYSFGILVLEIV
||||.|||.|  ||.
KSDVWSFGVLMWEIF
Kinase LLEC_h-2.AA TK-Unique 211-414 28 6.3e-32 107.42 In-house 1-233 (294) Show / Hide 
Range on Protein: 211-414
Range on HMM: 1-233/294
Sequence Identity: 28% (67 aa)

ADFKEVLGRGGTSTVYKGFLQNTP---TSRIEVAVKDLQSNSPDHEAEQQFREELNMISRVR-HQNLVALQGWCHEHD-KLLLVYECMSKGSLDKVLFTS
  ...|.|.|  ..|..| . ...     .. |||| |. |. |.. .|.|  |..| . .  |.|.| . | | . |   ....| ...|.|.. | |.
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTD-KQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTC

A---------------------SGSTNPLSWNQRFNIIRCVAEALRYLHEGLEKRIVHRDIKAANVLLDERMTAKVGDFGLARLMQHTIGSQTMTRAGTF
.                     . .|.|.|  . ....  .| .. ||.. . |.|||||. | |||| |. ..|..|||.||  ...   ..|.. |. 
RPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLAS-QRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRI

G--YISPELAY--SGRA-TEKSDVYSFGILVLEIV
   . .||  .   | . |.||||.|||.|  ||.
PIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIF
Kinase LLEC_h-2.AA UTK 211-416 24 1e-31 105.78 In-house 1-236 (296) Show / Hide 
Range on Protein: 211-416
Range on HMM: 1-236/296
Sequence Identity: 24% (59 aa)

ADFKEVLGRGGTSTVYKGFLQNTP--TSRIEVAVKDLQSNSPDHEAEQ---QFREELN---MISRVR-HQNLVALQGWCHEHDKLLLVYECMSKGSLDKV
  . . ||.|   .|.|. ... .       ||||..|. ...  ..    .|.|| .   | .... |.|.. |.| |     ...|.|.|..|.|...
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LFTSAS---GSTNPLSWNQRFNIIRCVAEALRYLHEGLEKRIVHRDIKAANVLLDER-------MTAKVGDFG---LARLMQH-----TIGSQTMTRAGT
| ...    . .  |.  ||    . .|... |||   ....||||. | |.|...        |..|..|||   ..|...        ... . .|  
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLH---SCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQH

FGY-----ISPELAYSG-RATEKSDVYSFGILVLEIVAG
..       .||  ... | |.||||.|||... ||...
QDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTW
Kinase LLEC_h-2.AA RIPK 217-419 25 8.2e-31 102.21 In-house 1-227 (290) Show / Hide 
Range on Protein: 217-419
Range on HMM: 1-227/290
Sequence Identity: 25% (60 aa)

LGRGGTSTVYKGFLQNTPTSRIEVAVKDLQSNSPDHE----AEQQFREELNMISRVRHQNLVALQGWCHEHDK------LLLVYECMSKGSLDKVLFTSA
.|.|| ..|.| .     . . .||.|   .  .. .     ...  ||  .  . |... | . | | . ..      . .| | | .||| ..| |  
VGGGGFGEVFKARHR---HWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKW

SGSTNPLSWNQRFNIIRCVAEALRYLHEGLEKR--IVHRDIKAANVLLDERMTAKVGDFGLARLMQHTIGSQTMT---------------RAGTFGYISP
.    |. |  |. .|  ....  |||    .   | ||| | .|.|.|  . .|. |||||  |.   .|. ..               | ||  |. |
PYQHHPDPWPLRCRMIHEISCGMCYLH---SMNPPIIHRDLKPENILVDNNFHVKIADFGLATWMM---WSHSHQDRCNQREVYSMKSKNRWGTLSYMPP

ELAY---SGR---ATEKSDVYSFGILVLEIVAGRRA
|.     . .   .|.|.|||||.|.. |. ... .
EHFRTDNKKPIKVVTPKYDVYSFAIVMWEVLTQKHP
Kinase LLEC_h-2.AA TyrKc 211-487 22 4.2e-30 107.26 SMART 1-280 (280) Show / Hide 
Range on Protein: 211-487
Range on HMM: 1-280/280
Sequence Identity: 22% (69 aa)

ADFKEVLGRGGTSTVYKGFLQNTPTSRIEVAVKDLQSNSPDHEAEQQFREELNMISRV--RHQNLVALQGWCHEH-------DKLLLVYECMSKGSLDKV
  ....||.|   .|||| .       |.|||| |....     .. |..|... ...  .|.|.|.| | | ..       . |..| | |..|.|.. 
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

LFTSASGSTNPLSWNQRFNIIRCVAEALRYLHEGLEKRIVHRDIKAANVLLDERMTAKVGDFGLARLMQHT---------IGSQT--MTRA-GTFGYISP
|  .       |.. .  ..   .|.  .|||.    ...|||. | |.|..|. |.|..||||.|   .          . ...   ...       .|
LRKHRPK----LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAP

ELAYSGRATEKSDVYSFGILVLEIVAGRRAVDHR-----FAGDTKMVLLEWAGTVSQPAELVDPRIQDGIDMKQVERIIQLALRCCSWHSEERPTMRLCC
|    |. |.||||.|||..  ||                  .  . ...  .   ||..   | .         . . |. ..|.    |.|||.. ..
ECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-P-MSF---VCCPDEMYQIMKQCWHEDPEDRPTFSEIH

QIL
...
ECF
Kinase LLEC_h-2.AA TK 456-487 18 0.000545 8.42 In-house 451-486 (486) Show / Hide 
Range on Protein: 456-487
Range on HMM: 451-486/486
Sequence Identity: 18% (7 aa)

MKQVE-----RIIQL-ALRCCSWHSEERPTMRLCCQIL
| . .      ....  ..|...  |.|||.. . . |
M-H-PPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase LLEC_h-2.AA MLK 474-487 35 0.088585 2.11 In-house 278-291 (291) Show / Hide 
Range on Protein: 474-487
Range on HMM: 278-291/291
Sequence Identity: 35% (5 aa)

SEERPTMRLCCQIL
...||..| . |.|
PHKRPSFRQIVQHL
Kinase LLEC_h-2.AA Pkinase_Tyr 464-487 29 0.97567 3.12 Pfam 247-270 (270) Show / Hide 
Range on Protein: 464-487
Range on HMM: 247-270/270
Sequence Identity: 29% (7 aa)

QLALRCCSWHSEERPTMRLCCQIL
.| ..|  .  |.|||.. . ..|
DLMKQCWHYDPEDRPTFSEIHEQL