Gene LRR11_e (S.moellendorffii)

LRR11_e

Species: S.moellendorffii
Alias: LRR11_e
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: LRR11

Sequence

Name Sequence Type Origin Length Description Download
LRR11_e.AA Protein None 1031 None Fasta, JSON
LRR11_e.NA RNA None 3096 None Fasta, JSON
LRR11_e.kin_dom Protein Kinase Domain None 269 None Fasta, JSON

Protein domain

Protein domains of LRR11_e.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LRRNT_2 LRR11_e.AA LRRNT_2 50-68 50 6.6e-05 18.83 Pfam 25-46 (46) Show / Hide 
Range on Protein: 50-68
Range on HMM: 25-46/46
Sequence Identity: 50% (11 aa)

LSSWSRN---SSCCQWRGVRCA
||||. .   |.||.|.|| | 
LSSWNPSSSDSDCCSWTGVTCD
LRR_TYP LRR11_e.AA LRR_TYP 130-156 55 0.005226 17.24 SMART 1-24 (24) Show / Hide 
Range on Protein: 130-156
Range on HMM: 1-24/24
Sequence Identity: 55% (15 aa)

LPRLERLDLSANNLSGPILLPPGSFQA
|| |..|||| |.|     |||| || 
LPNLRELDLSNNQL---THLPPGAFQG
LRR_1 LRR11_e.AA LRR_1 132-157 41 0.005249 14.83 Pfam 1-26 (26) Show / Hide 
Range on Protein: 132-157
Range on HMM: 1-26/26
Sequence Identity: 41% (12 aa)

RLERLDLSA-N--NLSGPILLPPGSFQAA
.|..||||  |  ||.|   .||..| . 
NLQHLDLSGCNCCNLTGH--IPPSCF-NL
LRR_1 LRR11_e.AA LRR_1 108-130 40 0.019363 12.82 Pfam 1-26 (26) Show / Hide 
Range on Protein: 108-130
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

GLSHLDLSS-N--ALSGSFPGN-ASSL
 | |||||. |   |.|..| .   .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP LRR11_e.AA LRR_TYP 106-125 45 0.353882 3.55 SMART 1-24 (24) Show / Hide 
Range on Protein: 106-125
Range on HMM: 1-24/24
Sequence Identity: 45% (11 aa)

LRGLSHLDLSSNALS----GSFPG
|. | .||||.|.|.    | | |
LPNLRELDLSNNQLTHLPPGAFQG
LRR_1 LRR11_e.AA LRR_1 178-197 42 0.017339 12.99 Pfam 1-26 (26) Show / Hide 
Range on Protein: 178-197
Range on HMM: 1-26/26
Sequence Identity: 42% (11 aa)

KLQVLDLSN-N--ALSGQIFE---SL
.||.||||. |   |.|.| .   .|
NLQHLDLSGCNCCNLTGHIPPSCFNL
LRR_1 LRR11_e.AA LRR_1 205-227 28 0.005352 14.8 Pfam 1-26 (26) Show / Hide 
Range on Protein: 205-227
Range on HMM: 1-26/26
Sequence Identity: 28% (8 aa)

QLRVLNFSG-N--DIS-SRIPAS-ITKC
.|..|..|| |   .. . || | . ..
NLQHLDLSGCNCCNLTGH-IPPSCF-NL
LRR_1 LRR11_e.AA LRR_1 253-275 33 0.003649 15.39 Pfam 1-26 (26) Show / Hide 
Range on Protein: 253-275
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

LLRSIRLSF-N--SLSGSIPSE-LSSL
 |... ||  |  .|.|.||.. . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP LRR11_e.AA LRR_TYP 251-275 36 0.141588 6.81 SMART 1-24 (24) Show / Hide 
Range on Protein: 251-275
Range on HMM: 1-24/24
Sequence Identity: 36% (9 aa)

LPLLRSIRLSFNSLSGSIPSELSSL
|| ||. .||.| |  ..|... . 
LPNLRELDLSNNQL-THLPPGAFQG
LRR_1 LRR11_e.AA LRR_1 237-251 36 7.811693 3.58 Pfam 9-26 (26) Show / Hide 
Range on Protein: 237-251
Range on HMM: 9-26/26
Sequence Identity: 36% (7 aa)

D-N--RLQGRIPSS-LSQL
. |  .|.| ||.| . .|
GCNCCNLTGHIPPSCF-NL
LRR_1 LRR11_e.AA LRR_1 277-288 33 16.371904 2.44 Pfam 1-15 (26) Show / Hide 
Range on Protein: 277-288
Range on HMM: 1-15/26
Sequence Identity: 33% (5 aa)

NLEELWLNK-N--SI
||..| |.  |  ..
NLQHLDLSGCNCCNL
LRR_1 LRR11_e.AA LRR_1 300-322 18 0.44005 8.01 Pfam 1-26 (26) Show / Hide 
Range on Protein: 300-322
Range on HMM: 1-26/26
Sequence Identity: 18% (5 aa)

SLRVFSARE-N--RLSGQIAVN-CSSM
.|.. . .  |  .|.|.|  . . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR11_e.AA LRR_1 325-347 37 0.005215 14.84 Pfam 1-26 (26) Show / Hide 
Range on Protein: 325-347
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

SLAYLDLSY-N--LLNGTIPAA-IGEC
.| .||||. |   | |.||   .  .
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR11_e.AA LRR_1 373-396 40 0.001519 16.74 Pfam 1-26 (26) Show / Hide 
Range on Protein: 373-396
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

NLTTLMLSK-N--NLVGRIPLESLREC
||..| ||  |  ||.| || ...  .
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR11_e.AA LRR_1 349-371 37 0.006806 14.43 Pfam 1-26 (26) Show / Hide 
Range on Protein: 349-371
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

RLETLALTG-N--FLEGRIPSQ-LGSL
.|..| | | |   |.| ||.  . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP LRR11_e.AA LRR_TYP 371-395 36 0.099649 8.06 SMART 1-24 (24) Show / Hide 
Range on Protein: 371-395
Range on HMM: 1-24/24
Sequence Identity: 36% (9 aa)

LTNLTTLMLSKNNLVGRIPLESLRE
|.||..| || |.|  ..| . .. 
LPNLRELDLSNNQL-THLPPGAFQG
LRR_1 LRR11_e.AA LRR_1 398-413 31 73.680515 0.12 Pfam 1-19 (26) Show / Hide 
Range on Protein: 398-413
Range on HMM: 1-19/26
Sequence Identity: 31% (6 aa)

SLVALVLSK-N--YFSGTL
.|  | ||  |   ..|..
NLQHLDLSGCNCCNLTGHI
LRR_1 LRR11_e.AA LRR_1 425-447 37 0.73026 7.23 Pfam 1-26 (26) Show / Hide 
Range on Protein: 425-447
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

NLQLLAVGN-S--NLSGTIPLW-LTNS
||| | ...    ||.|.|| . . | 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR11_e.AA LRR_1 449-471 37 0.001342 16.93 Pfam 1-26 (26) Show / Hide 
Range on Protein: 449-471
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

KLQVLDLSW-N--SFTGEVPLW-IGDF
.||.||||  |  ..||..| . .  .
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR11_e.AA LRR_1 473-495 33 0.001707 16.56 Pfam 1-26 (26) Show / Hide 
Range on Protein: 473-495
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

HLFYVDLSN-N--SFSGALPDQ-LANL
.| . |||. |  ...| .|.  . ||
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR11_e.AA LRR_1 558-580 44 0.013286 13.4 Pfam 1-26 (26) Show / Hide 
Range on Protein: 558-580
Range on HMM: 1-26/26
Sequence Identity: 44% (12 aa)

RLVSLDLGI-N--LLSGVIPAS-LGNL
.| .|||.  |   |.| || | . ||
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 LRR11_e.AA LRR_1 582-604 40 0.026617 12.33 Pfam 1-26 (26) Show / Hide 
Range on Protein: 582-604
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

NLESMDLSQ-N--SLGGAIPTT-LTRL
||.. |||  |  .| | ||   .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP LRR11_e.AA LRR_TYP 580-604 36 0.110258 7.7 SMART 1-24 (24) Show / Hide 
Range on Protein: 580-604
Range on HMM: 1-24/24
Sequence Identity: 36% (9 aa)

LSNLESMDLSQNSLGGAIPTTLTRL
|.||.. ||| | |  ..|  . . 
LPNLRELDLSNNQL-THLPPGAFQG
LRR_TYP LRR11_e.AA LRR_TYP 556-579 33 0.200049 5.58 SMART 1-24 (24) Show / Hide 
Range on Protein: 556-579
Range on HMM: 1-24/24
Sequence Identity: 33% (8 aa)

LRRLVSLDLGINLLSGVIPASLGN
|. | .|||. | |. . |  ...
LPNLRELDLSNNQLTHLPPGAFQG
LRR_1 LRR11_e.AA LRR_1 606-630 35 0.266898 8.78 Pfam 1-26 (26) Show / Hide 
Range on Protein: 606-630
Range on HMM: 1-26/26
Sequence Identity: 35% (10 aa)

SLARLNLSF-N--KLEGPIPLGNQFSTF
.| .|.||  |  .|.| || .  |  .
NLQHLDLSGCNCCNLTGHIPPS-CF-NL
Kinase LRR11_e.AA TKL 762-1024 21 2.9e-57 196.55 In-house 1-364 (364) Show / Hide 
Range on Protein: 762-1024
Range on HMM: 1-364/364
Sequence Identity: 21% (80 aa)

VGCGGFGLVFVASLPD---------GTKVAIKRLTG---------------------------DCLQVEREFEAEVQALAMADHPNLVTLQGYSSYGEH-
.| |||| |. . .           |. ||.|..                             .  . . ..| |.  . . .|||.| . ||. .... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------RLLIYSYMENGSLDSWLHESAKHLDWSTRLDIARGAARGLAYLHL----ACQPH--IVHRDIKSSNILLDGRFV--------------
              ... |...||| . ||       |. |...|...|||..|||     .|.    |.|||.||.|||.|  .               
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCT-KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC

AHLADFGLARLMLPTATHVSTE------------------MVGTLGYIPPEYAQ----------------SWMASPKGDVYSFGVVLLELLSRRRPVDVC
. ..||||.| | ..     |.                   .||... .||  .                .. .|.| ||||||.|| |.|.|.|| .  
CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDY

RANGVYDLVAWVREMKGAGRGVEVMDPALRE--------RGNEEEMERMLEVACQCINPNPARRPGIEEVVTWL
  . ..     . ||  ...... . | . .          ..  ...| . . .| ...|  ||  .|.. .|
PYMPMIFQDP-FEEMF-MMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase LRR11_e.AA IRAK 756-956 34 2.5e-52 180.19 In-house 1-225 (317) Show / Hide 
Range on Protein: 756-956
Range on HMM: 1-225/317
Sequence Identity: 34% (78 aa)

FDQSNIVGCGGFGLVFVASLPDGTK--VAIKRLTG----DCLQVEREFEA---EVQALAMADHPNLVTLQGYSSYGEHRLLIYSYMENGSLDSWLHESAK
|...|  | |||| |. . . ..|   .|.|.|       . .....| .   |.....   |||.| | ||.. ..   |.| || ||||   |.  . 
FHKDNRIGEGGFGCVYRGQW-KNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDG

--H---LDWSTRLDIARGAARGLAYLHLAC-Q-PHIVHRDIKSSNILLDGRFVAHLADFGLAR------LMLPTAT---HVSTEMVGTLGYIPPEYAQ--
      | | .|..|. |.|.|. .|| .    |.| |.||||.||||| .|.. ..||||.|       .. .     ..|.  .||. | |||.    
QCPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPII-HGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSH-VRGTTWYMPPEFIRDP

SWMASPKGDVYSFGVVLLELLSRRRPVD
.   ..| ||||||.||||.|. .|.|.
QGQLTKKTDVYSFGIVLLEVLTGCRAVY
Kinase LRR11_e.AA Pkinase 756-1024 20 7.8e-44 156.07 Pfam 1-293 (293) Show / Hide 
Range on Protein: 756-1024
Range on HMM: 1-293/293
Sequence Identity: 20% (63 aa)

FDQSNIVGCGGFGLVFVASLPDGTK-VAIKRLTGDCLQVEREFEA-----EVQALAMADHPNLVTLQGYSSYGEHRLLIYSYMENG----SLDSWLH-ES
.    ..| |.|| |. .   .  | ||.|..  .  . . . ..     |.| ... .||| |.| ..  .. |  ..  |.|.|    .| .... ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

AKHL--DWSTRLDIARGAARGLAYLHLACQPHIVHRDIKSSNILLDGRFVA----HLADFGLARLM-LPTATHVSTEMVGTLGYIPPEYAQ-SWMASPKG
 . .  .. .  ....  .|||.|.|      |.|||.|..|||.| . .     ...|||||... .   .   |  .||..|..||  . . . .|| 
HGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS--MTTFCGTPWYMAPEVIRGGQYYGPKV

DVYSFGVVLLELLSRRRPVDVC------RANGVYDLVAW-----------------VREMKGAGRGVEVMDPALRERGNEEEMERMLEVACQCINPNPAR
|..|.|..| |.|..| | . .      . . ..... .                 .|  . .           ...   .  | .... . |....|..
DMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRH-W-H---------F-HWTF-HNWSEECKDFIKWCLCKDPKK

RPGIEEVVTW--L
||..|...    .
RPTAEQILQHPWF
Kinase LRR11_e.AA S_TKc 756-1024 21 1.3e-41 145.43 SMART 1-231 (231) Show / Hide 
Range on Protein: 756-1024
Range on HMM: 1-231/231
Sequence Identity: 21% (62 aa)

FDQSNIVGCGGFGLVFVASLPD-GTKVAIKRLTGDCLQVEREFEAEVQALAMADHPNLVTLQGYSSYGEHRLLIYSYMEN--GSLDSWLHESAKH-----
..  ...| |.|| |. .   . | .||||..        . .. |.| | . .|||.|.| ..    .|  ..  |...  |.| . ...  .|     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LDWSTRLDIARGAARGLAYLHLACQPHIVHRDIKSSNILLDGRFVAHLADFGLARLMLPTATHVSTEMVGTLGYIPPEYAQSWMASP-KGDVYSFGVVLL
..  .   ...  ...|.|.|   . .|.|||.| .|||||   .  ..||||||..        | ..||. |..||       .. | |..|.|..| 
FPE-HARFYMYQICCALEYCH--SH-GIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

ELLSRRRPVDVCRANGVYDLVAWVREMKGAGRGVEVMDPALRERGNEEEMERMLEVACQCINPNPARRPGIEEVVT---------WL
|.|... | .        .. .  . ..                      . ...  ..| . .|..||.. |. .         |.
EMLCGYPPFP--------QMQMMFKKIG---------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase LRR11_e.AA TKL-Unique 758-968 28 4.8e-39 135.37 In-house 1-247 (290) Show / Hide 
Range on Protein: 758-968
Range on HMM: 1-247/290
Sequence Identity: 28% (70 aa)

QSNIVGCGGFGLVFVASLPDGTKVAIKRLTG--DCL-QVEREFEAEVQALAMAD-HPNLVTLQGYSS----YGEHRLLIYSYMENGSLDSWLH-------
 .| .| ||.| |. .  . |..||||..    |   ....||| ||  . . . |||.|.. ||.     |  .. .. .|.. |||.. ||       
FWNKIGEGGYGQVYKGKWR-GYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

--ESAKHLDWSTRLDIARGAARGLAYLHLACQPHIVHRDIKSSNILLDGR-----FVAHLADFGLARLML-PTATHVS-------TEMVGTLGYIPPEYA
  .. . |... |...|. .|.|. |||    | | |||.||||.|.| .     . . ..||||...    ... ..       .. .|.. ...||  
NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVL

QS--WMASPKGDVYSFGVVLLELLSRRR------PVDVCRANGVYDLVA
 .   . | | ||||||.|| |...| .      | . .  .... .|.
RMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVH
Kinase LRR11_e.AA LRRK 756-956 25 2e-35 122.77 In-house 1-284 (351) Show / Hide 
Range on Protein: 756-956
Range on HMM: 1-284/351
Sequence Identity: 25% (75 aa)

FDQSNIVGCGGFG-LVFVASLPD---------------------------GTKVAIKRLTGD----------------------------------CLQV
.   . .| |||| .|. | . .                           ...|||| .. |                                  |. .
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

EREFEAEVQALAMADHPNLVTLQGYSSYGEHRLLIYSYMENGSLDSWLHESAKH--------LDWSTRLDIARGAARGLAYLHLACQPHIVHRDIKSSNI
 |||  ||  .   .|||.| | |..   ... ..  |. .|.|.. ||.....        ..|...| ||   |.|..|||  . | |.||| || ||
FREFRHEVWIMSHLNHPNIVSLKGFCI--HPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLH-SHNPPIIHRDLKSPNI

LL---D---------GRFVAHLADFGLARLMLPTATHV--STEMVGTLGYIPPEYAQSW---MASPKGDVYSFGVVLLELLSRR-RPVD
||   .            .|..||||. | |  ...|      .||. |.  ||  .       . | |.||||..| |||.|. .| |
LLWSSPQNHSPNYPNAHVCAKIADFGISR-MF-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFD
Kinase LRR11_e.AA TK 756-951 15 1.9e-34 112.31 In-house 1-390 (486) Show / Hide 
Range on Protein: 756-951
Range on HMM: 1-390/486
Sequence Identity: 15% (60 aa)

FDQSNIVGCGGFG---LVFVASLPDG--------------------------TKVAIKRLTGDCLQVEREFEA--------------EVQALAMAD----
    .  | | ||    |. . . ..                          |.||.| |. .. . ..||..              |.....| .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNLVTLQGYSSYG------------EHRLLIYSYMENGS----LDSWLHESAKH--------------------------------------------
 |||.| | |... |            |. ...  ||..|.    |...|... ..                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LDWSTRLDIARGAARGLAYLHLA----CQPHIVHRDIKSSNILLDGRFV-----------AHLADFG--
                               |.  ..| ... .|.|..|||        ...||||.   |.|.. . |           . .||||  
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

------LARLMLPTATHVSTEMVGTLG-------------------------YIPPEYAQSWM---------ASPKGDVYSFGVVLLELLSR
      ||| . .    ....  || .                         . .||  ..            ..| ||.||||.. |....
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTY
Kinase LRR11_e.AA MLK 756-954 26 5.8e-34 115.25 In-house 1-235 (291) Show / Hide 
Range on Protein: 756-954
Range on HMM: 1-235/291
Sequence Identity: 26% (63 aa)

FDQSNIVGCGGFGLVFVASLPDGTK-----VAIKRLT---GDCLQVE----REFEAEVQALAMADHPN-----LVTLQGYSSYGEHRLLIYSYMENGSLD
.. . ..| |.|| |. .    ..      ||.|| .     . ...    ..|| |.  |.. .|||      . . . .... | ...  |.|.||| 
IQFHEWIGSGSFGKVWKGRW-RNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLY

SWLHESAK-------------HLDWSTRLDIARGAARGLAYLHLACQPHIVHRDIKSSNILLD------GRFVAHLADFGLARLMLPT-ATHVSTEMVGT
. ||.  .               | .  ...|   |||..|||   .. |.|||.||.|||.|      .  ..  .|||..| .  . ...  . . ||
NVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNM--MSNAGT

LGYIPPEY---AQSWMASPKGDVYSFGVVLLELLSRRRP
. .  ||    ... . | | ||.|.|||| |.|.|. |
YAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVP
Kinase LRR11_e.AA Pkinase_Tyr 756-904 25 1.4e-28 97.45 Pfam 1-161 (270) Show / Hide 
Range on Protein: 756-904
Range on HMM: 1-161/270
Sequence Identity: 25% (42 aa)

FDQSNIVGCGGFGLVFVASLP-----DGTKVAIKRLTGDCLQVE---REFEAEVQALAMA-DHPNLVTLQGYSS-YGEH--RLLIYSYMENGSLDSWLHE
       | | || |. . .      ....||.| |  .. . .   ..| .|.. .    .|||.| | |  .  ||.   ...  ||..|.|.. |..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

S---AKHLDWSTRLDIARGAARGLAYLHLACQPHIVHRDIKSSNILLDGRFVAHLADFGLARLM
     ..|. .. |....  |.|..||.      ..|||.   |.|..  .|.  .||||||..
HREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDI
Kinase LRR11_e.AA RIPK 762-954 31 1.6e-26 87.37 In-house 1-227 (290) Show / Hide 
Range on Protein: 762-954
Range on HMM: 1-227/290
Sequence Identity: 31% (71 aa)

VGCGGFGLVFVASLPD-GTKVAIKRLTGDC------LQVEREFEAEVQALAMADHPNLVTLQGYSSYGEH------RLLIYSYMENGSLDSWLHESAKH-
|| |||| || |   . |. ||.|  ..         |.. .   |......... . | . |     |         .   |||||||   ||   .. 
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ

---LDWSTRLDIARGAARGLAYLHLACQPHIVHRDIKSSNILLDGRFVAHLADFGLARLMLPTATHV------------STEMVGTLGYIPPEYAQ--SW
   . |. |  .    ..|  |||   .| | ||| | .|||.|. | . .||||||  |     |             | .  ||| |.|||       
HHPDPWPLRCRMIHEISCGMCYLH-SMNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDNK

MA----SPKGDVYSFGVVLLELLSRRRP
 .    .|| |||||..|. |.|... |
KPIKVVTPKYDVYSFAIVMWEVLTQKHP
Kinase LRR11_e.AA Dicty4 756-949 31 2e-26 85.26 In-house 1-211 (277) Show / Hide 
Range on Protein: 756-949
Range on HMM: 1-211/277
Sequence Identity: 31% (67 aa)

FDQSNIVGCGGFGLVFVASLPDGTKVAIKRL----TGDCLQVEREFEAEVQALAMADHPNLVTLQGYSS----YGEHRLLIYSYMENGSLDSWLHE----
 .  .. | |.|| |. ..   |..||.| |    ... .    || .||  ..   |||.... |..       .  .    ||  |.| | ||     
INIEQRIGKGSFGEVYKGTWR-GKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSE

--SAKHLDWSTRLD---IARGAARGLAYLHLACQPHIVHRDIKSSNILLDGRFVAHLADFGLARLMLPTATHVS--TEMVGTLGYIPPEYAQSWMASPKG
  . . |||....    .|. ||||...|| .| | |.|||.||.|.| |  ...  .||||...| .  .|    . ..|| ..  ||  ..     | 
QQQSIKLDWPLIKRAMRMAFDAARGMNWLH-CCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKA

DVYSFGVVLLELL
|||||| || |.|
DVYSFGIVLWEIL
Kinase LRR11_e.AA CZAK 778-954 29 2.1e-26 92.96 In-house 22-221 (279) Show / Hide 
Range on Protein: 778-954
Range on HMM: 22-221/279
Sequence Identity: 29% (59 aa)

GTKVAIKRLTGDCLQVERE------FEAEVQALAMADHPNLVTLQGYSSYGE--HRLLIYSYMENGSLDSWLHESAKHLDW--STRLDIARGAARGLAYL
|. |||| .. .      |      |. ||  .    ||| |   |  | .   |.  .  .|. |||.  | .    .    . .. .|.  |||  ||
GKDVAIKIIHRNQFRNKDENKEENMFQKEVSIMSKLCHPNCVQFLGACSEDGPNHHCIVMEWMGGGSLRRLLTDHYFYHKQNPHLQWNMAIDIARGMNYL

HLACQP-HIVHRDIKSSNILLDGRFV-------------AHLADFGLARLMLPTATHVSTEMVGTLGYIPPEYAQSWMASPKGDVYSFGVVLLELLSRRR
|    |  |.|||  |.|||||                 .  .|||| |.| . ..   |  .| | .  ||       ..| |||||| .| ...  . 
HDNWKPNPILHRDLSSRNILLDHSYTPKNPVVSSRQDIICKINDFGLSREMMEQPFEM-TQTMGCLCWMAPECFKGENYTEKVDVYSFGMILWCIITCDQ

P
|
P
Kinase LRR11_e.AA TyrKc 756-1024 20 2.4e-26 94.77 SMART 1-280 (280) Show / Hide 
Range on Protein: 756-1024
Range on HMM: 1-280/280
Sequence Identity: 20% (61 aa)

FDQSNIVGCGGFGLVFVASLPDGTKVAIKRLTGDCLQVEREFEAEVQALAMA--DHPNLVTLQGYSSYG-------EHRLLIYSYMENGSLDSWLHESAK
     . |.| || |. . .   ..||.| |  |.   ...|  | . . .   .|||.| | |. . .       |  ...  ||..|.|.. |... .
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

HLDWSTRLDIARGAARGLAYLHLACQPHIVHRDIKSSNILLDGRFVAHLADFGLARLMLPT--------ATHV----STEMVGTLGYIPPEYAQSWMASP
.| ... |...  .|.| .|||     ...|||.   |.|.. ....  .||||.|               ..    .. ..  .   .||  .  . ..
KLCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

KGDVYSFGVVLLELLSR-RRPVDV---CRANGVYDLVAWVREMKGAGRGVEVMDPALRERGNEEEM------ERMLEVACQCINPNPARRPGIEEVVTWL
| ||.||||.. |....   |            ......|.. .   .  ..           . |      . | ..  || . .|. ||  .|..  .
KSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDY----------P-MSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase LRR11_e.AA DRK 759-954 32 8.5e-25 80.94 In-house 4-201 (258) Show / Hide 
Range on Protein: 759-954
Range on HMM: 4-201/258
Sequence Identity: 32% (65 aa)

SNIVGCGGFGLVFVASLPDGTKVAIKRLTGDCLQ---VEREFEAEVQALAMADHPNLVTLQGYSSYGEHRLLIYSYMENGSLDSWLHESAKHLDWSTRLD
 | .| |..| ||  .   ||.||.|.|  .         ||  |.  .    ||| .   |        . .  ||  ||| . ||. .  .||. .. 
GNRIGRGNYGEVFRGTW-RGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLMKQ

IARGAARGLAYLHLACQPHIVHRDIKSSNILLDGRFVAHLADFGLAR----LMLPTATHVSTEMVGTLGYIPPEYAQSWMASPKGDVYSFGVVLLELLSR
..  .|.|. |||  | | |.||| || | | |  .    |||||.         ...     |.|| . . ||   .     | |||||..|| |.. |
MMFDCAKGMIYLH-CCNPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQHKFAMT---MCGTPCWTAPEVLRNQRYTEKADVYSFAIVLWECVTR

RRP
  |
QDP
Kinase LRR11_e.AA DRK 1006-1026 38 0.000678 9.12 In-house 238-258 (258) Show / Hide 
Range on Protein: 1006-1026
Range on HMM: 238-258/258
Sequence Identity: 38% (8 aa)

CINPNPARRPGIEEVVTWLEG
| | .|  ||  .|..  || 
CWNEDPQHRPSMQECLERLEA
Kinase LRR11_e.AA TK 993-1024 18 0.000769 7.91 In-house 454-486 (486) Show / Hide 
Range on Protein: 993-1024
Range on HMM: 454-486/486
Sequence Identity: 18% (6 aa)

EEEMERML-EVACQCINPNPARRPGIEEVVTWL
..... .. .. .|| ...|..||  ....  |
PHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase LRR11_e.AA IRAK 992-1024 24 0.008237 5.99 In-house 285-317 (317) Show / Hide 
Range on Protein: 992-1024
Range on HMM: 285-317/317
Sequence Identity: 24% (8 aa)

NEEEMERMLEVACQCINPNPARRPGIEEVVTWL
.... . |. .||.|     .||. ...|.  |
PPNMEKEMCQCACCCGHHRANRRCDMAWVMQQL
Kinase LRR11_e.AA MLK 1005-1024 40 0.011329 5.25 In-house 272-291 (291) Show / Hide 
Range on Protein: 1005-1024
Range on HMM: 272-291/291
Sequence Identity: 40% (8 aa)

QCINPNPARRPGIEEVVTWL
|| |..|..||   ..|. |
QCWNQDPHKRPSFRQIVQHL
Kinase LRR11_e.AA Dicty4 1006-1026 34 0.03152 3.43 In-house 255-277 (277) Show / Hide 
Range on Protein: 1006-1026
Range on HMM: 255-277/277
Sequence Identity: 34% (8 aa)

CINPNPARRPGIEEVVTW--LEG
| ...| .||  ||..    || 
CWDHDPQHRPSFEEIIQRRILEH
Kinase LRR11_e.AA TKL-Unique 1005-1024 35 0.096612 2.14 In-house 271-290 (290) Show / Hide 
Range on Protein: 1005-1024
Range on HMM: 271-290/290
Sequence Identity: 35% (7 aa)

QCINPNPARRPGIEEVVTWL
|| ...|  ||  .|... |
QCWHHDPSQRPSFDEIIHRL
Kinase LRR11_e.AA Pkinase_Tyr 937-951 46 0.566365 3.92 Pfam 196-210 (270) Show / Hide 
Range on Protein: 937-951
Range on HMM: 196-210/270
Sequence Identity: 46% (7 aa)

DVYSFGVVLLELLSR
||.||||.. |....
DVWSFGVLMWEIFTY
Kinase LRR11_e.AA Pkinase_Tyr 1004-1024 33 6.157192 0.41 Pfam 250-270 (270) Show / Hide 
Range on Protein: 1004-1024
Range on HMM: 250-270/270
Sequence Identity: 33% (7 aa)

CQCINPNPARRPGIEEVVTWL
.|| ...|..||  .|..  |
KQCWHYDPEDRPTFSEIHEQL