Gene LRR2_e (S.moellendorffii)
LRR2_e
Species: S.moellendorffii
Alias: LRR2_e
External Links:
Annotation:
Sequence
Protein domains of LRR2_e.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | LRR2_e.AA | IRAK | 164-364 | 34 | 5.5e-53 | 182.36 | In-house | 1-226 (317) | Show / Hide |
Range on Protein: 164-364 Range on HMM: 1-226/317 Sequence Identity: 34% (79 aa) FNPENLIGKGGYADVYKGCLPSGE-LVAVKRLTRGGKEEQGTS---FLT---ELGVLGHVSHPNATPLLGFCVDGGLF-LVFHFLPHGSLAAMLHGSR-- |...|.||.||...||.| . . .|||.| . . ... . |.. || |. ||| ||.|.| ... . ||. ..| ||| . |.. FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ --L--MEWPARFKAAIGTARGLHYLHSNC-RRRIIHRDIKSSNILLGPDFEPQITDFGLAKWL--PSEWTHHTV------PVEGTFGYLAPEYFL--HGI . .|. |.. ..|||.|...||.| |||.||||.|||| .|.| |.||||. |. ..|. | || |..||. |. CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQ VDEKTDVFAFGVLLLELVTGLRPIDS ||||. ||. |||..||.|. .. LTKKTDVYSFGIVLLEVLTGCRAVYD |
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Kinase | LRR2_e.AA | TKL | 170-361 | 23 | 1.3e-45 | 157.9 | In-house | 1-288 (364) | Show / Hide |
Range on Protein: 170-361 Range on HMM: 1-288/364 Sequence Identity: 23% (70 aa) IGKGGYADVYKGCLPS---------GELVAVKRLTRGG-KEEQGTS-------------------------FLTELGVLGHVSHPNATPLLGFCVDGG-- ||.||.. |||| . |. ||||.. . .|. .| . |. .. .||| ...|.| ... IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG ------------LFLVFHFLPHGSLAAMLHGSRLMEWPARFKAAIGTARGLHYLHSNCR-----RRIIHRDIKSSNILLGPDFE--------------PQ |..| . |.||| || |. |.. |...|||..||||. . |||||.||.|||. ... . CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCK ITDFGLAKWL-----PSEWTHH------------TVPVEG-TFGYLAPEYFL----------------HGIVDEKTDVFAFGVLLLELVTGLRP |.||||.... . . .. | .. |....||| . .. .||.||..||..| |..|. || ICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRP |
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Kinase | LRR2_e.AA | Pkinase | 164-358 | 24 | 1.1e-38 | 137.93 | Pfam | 1-208 (293) | Show / Hide |
Range on Protein: 164-358 Range on HMM: 1-208/293 Sequence Identity: 24% (53 aa) FNPENLIGKGGYADVYKGCLPSGEL-VAVKRLTRGGKEE--QGTSFL-TELGVLGHVSHPNATPLLGFCV-DGGLFLVFHFLPHG----SLAAMLH--GS . . ||.|... |||.. . . ||||.. . .... . | .. .|. .. ...||| |.... .. . .|. ....| .|..... . YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH RLM--EWPARFKAAIGTARGLHYLHSNCRRRIIHRDIKSSNILLGPDFEP----QITDFGLAK---WLPSEWTHHTVPVEGTFGYLAPEYFL-HGIVDEK . . .. . . ..||| |.||. .|||||.|..|||. . .. |.|||||| . ... ... . || .|.||| . . . | GCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTT---FCGTPWYMAPEVIRGGQYYGPK TDVFAFGVLLLELVTG |....|..| |...| VDMWSCGCILYEMLCG |
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Kinase | LRR2_e.AA | MLK | 164-358 | 27 | 3e-31 | 105.71 | In-house | 1-232 (291) | Show / Hide |
Range on Protein: 164-358 Range on HMM: 1-232/291 Sequence Identity: 27% (66 aa) FNPENLIGKGGYADVYKGCLPSGEL-----VAVKRLTRGG-----KEEQGTSFLTELGVLGHVSHPN----ATPLLGFCVD-GG-LFLVFHFLPHGSLAA .. . ||.|.. .|.|| ... ||||| . .... | .| | ..|||| ...| | . . ...| .....|||. IQFHEWIGSGSFGKVWKGRW-RNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN MLHGSRL--------------MEWPARFKAAIGTARGLHYLHSNCRRRIIHRDIKSSNILLGP------DFEPQITDFGLAKWLPSEWTHH---TVPVEG ||| | . .. | |||.|||||. . |||||.||.|||. . |.|||... .|... | VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSR----DWHQMCTNMMSNAG TFGYLAPEYF---LHGIVDEKTDVFAFGVLLLELVTG |. . ||| . .. ..|| ||. .||.| |..|. TYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTR |
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Kinase | LRR2_e.AA | TK | 164-357 | 16 | 9.7e-30 | 96.27 | In-house | 1-389 (486) | Show / Hide |
Range on Protein: 164-357 Range on HMM: 1-389/486 Sequence Identity: 16% (63 aa) FNPENLIGKGGYA---DVYKGCLPSG--------------------------ELVAVKRLTRGGKEEQGT----------------SFLTELGVLGH--V .. .|.| . .|||| . .. . |||| |. | ..| ... |. .. | ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG SHPNATPLLGFCVDGG-------------LFLVFHFLPHGS----LAAMLHGSRL--------------------------------------------- ||| |.| |..|. . .| . |||. | |. .| HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY -------------------------------MEWPARFKAAIGTARGLHYLHSN----CRRRIIHRDIKSSNILLGPDFE-----------PQITDFG-- . . . . |.|. ||||. ...|||. |.|.| . |.||| DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS ------LAKWLPSEWTHHTVPVEGTFG-------------------------YLAPEYFL---------HGIVDEKTDVFAFGVLLLELVT ||. ..|. ... .|| . ..||| .. .|. .|.||..||||. |..| RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFT |
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Kinase | LRR2_e.AA | LRRK | 164-363 | 24 | 6.6e-29 | 99.38 | In-house | 1-284 (351) | Show / Hide |
Range on Protein: 164-363 Range on HMM: 1-284/351 Sequence Identity: 24% (71 aa) FNPENLIGKGGYA-DVYKGCLPS---------------------------GELVAVKRLTRGG------------------------------KEEQGTS . |..||.||.. ||.. . . .. ||.| ..|.. |. .. LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA FLT---ELGVLGHVSHPNATPLLGFCVDGGLFLVFHFLPHGSLAAMLH---GSRL------MEWPARFKAAIGTARGLHYLHSNCRRR--IIHRDIKSSN | . |. .. | ||| .|.||| . | .| ..|||.| || ... . | . | |. |.|. ||||. . ||||| || | FREFRHEVWIMSHLNHPNIVSLKGFCIH-PLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSH---NPPIIHRDLKSPN ILLGPDFEPQ------------ITDFGLAKWLPSEWTHH--TVPVEGTFGYLAPEYFLHG---IVDEKTDVFAFGVLLLELVTGL-RPID ||| ... | |||. . .|. . ..|..|..||| . .||.|...||..| ||.|.. .| | ILLWSSPQNHSPNYPNAHVCAKIADFGISR-MF-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFD |
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Kinase | LRR2_e.AA | Dicty4-Unclassified | 167-358 | 31 | 3.8e-27 | 89.99 | In-house | 4-204 (263) | Show / Hide |
Range on Protein: 167-358 Range on HMM: 4-204/263 Sequence Identity: 31% (65 aa) ENLIGKGGYADVYKGCLPSGELVAVKRLTRGG---KEEQGTSFLTELGVLGHVSHPNATPLLGFCVDG-----GLFLVFHFLPHGSLAAMLH-----GSR |||| . |.|| | |||| . . || |. | .|| ..||| . | |. . | |.. | | . | . DQFIGKGHFSKVHKGNW-KGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQ LMEWPA--RFKAAIGTARGLHYLHSNCRRRIIHRDIKSSNILLGPDFEPQITDFGLAKWLPSEWTHHTVPVEGTFGYLAPEYFLHGIVDEKTDVFAFGVL . | |. |.|. .||. | .|||||||||||. .| | |||.. . |. || .|| | | ||. .... PIKLDDTLIIKYAFDIAQGMQHLHT---RNFIHRDIKSSNILMDKHFNIKIADFGISRVIDFNFNMTTIA--GTPKWESPECLMHESYNQKSDVYSYAMM LLELVTG | ||.|| LYELATG |
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Kinase | LRR2_e.AA | Dicty4 | 164-361 | 32 | 6.2e-27 | 87.0 | In-house | 1-216 (277) | Show / Hide |
Range on Protein: 164-361 Range on HMM: 1-216/277 Sequence Identity: 32% (71 aa) FNPENLIGKGGYADVYKGCLPSGELVAVKRL--TRGG-KEEQGTSFLTELGVLGHVSHPNATPLLGFCV-----DGGLFLVFHFLPHGSLAAMLHG---- | |..||||... |||| | |||| | . . |. ..|. | .. .||| ..| | | . | ..| |.|. || INIEQRIGKGSFGEVYKGTW-RGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSE ---SRLMEWPARFK---AAIGTARGLHYLHS-NCRRRIIHRDIKSSNILLGPDFEPQITDFGLAKWLPSEWTHHT--VPVEGTFGYLAPEYFLHGIVDEK | ..|| . . |. .|||. .||. |. .|||||.||.|.| .. ..||||.. . .| . . || .. ||| | .|| QQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNP--VIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEK TDVFAFGVLLLELVTGLRP ||. || .| |..|. | ADVYSFGIVLWEILTRQEP |
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Kinase | LRR2_e.AA | TKL-Unique | 166-361 | 29 | 6.5e-27 | 92.04 | In-house | 1-233 (290) | Show / Hide |
Range on Protein: 166-361 Range on HMM: 1-233/290 Sequence Identity: 29% (70 aa) PENLIGKGGYADVYKGCLPSGELVAVKRLTRGGKEEQGTS----FLTELGVLGHVS-HPNATPLLGFCVD-----GGLFLVFHFLPHGSLAAMLH----- . |.|| |||. |||| . |. ||.|.. .|.. . | |. .. ||| . . |.|.| . ...| ..|.||| || FWNKIGEGGYGQVYKGKWR-GYPVAIKQFHP--NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNN -----GSRLMEWPARFKAAIGTARGLHYLHSNCRRRIIHRDIKSSNILLGPD-----FEPQITDFGLAKWLPSEWTHHTV--------PVEGTFGYLAPE . . . | | || |.|..|||.. |||||.||||.|. . . .| ||||.| . .. . . ..|.| ..||| NNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPE YFLH--GIVDEKTDVFAFGVLLLELVTGLR------P . .|| ||..||. | |..|. . | VLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKP |
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Kinase | LRR2_e.AA | S_TKc | 164-432 | 23 | 7.9e-26 | 93.04 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 164-432 Range on HMM: 1-231/231 Sequence Identity: 23% (67 aa) FNPENLIGKGGYADVYKGCLPS-GELVAVKRLTRGGKEEQGTSFLTELGVLGHVSHPNATPLLGFCVDGGLFLVFHFLPH--GSLAAMLHGSR------- . ..||||... |||. . |..||.|.. ... |. .| . ||| |.....|. |..|. .... |.| ... . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP LMEWPARFKAAIGTARGLHYLHSNCRRRIIHRDIKSSNILLGPDFEPQITDFGLAKWLPSEWTHHTVPVEGTFGYLAPEYFLHGIVDE-KTDVFAFGVLL . | ||| .. ....| |.|| ..|||||.| .|||| . |.|||||. | . || |.||| . . | |. ..|..| FPE-HARFYMY-QICCALEYCHS---HGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCIL LELVTGLRPIDSTQKSLVMKVRPLLESANIQQLVDGRLKGAYNLSEVQKTILAARLCIRQSAIARPCMADVSSYTL----SPGF |...| | . ... . |.. . . | | . || .. . . | | YEMLCGYPPFP-QMQMMFKKIG------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | LRR2_e.AA | STE | 164-361 | 21 | 1.5e-25 | 87.28 | In-house | 1-267 (359) | Show / Hide |
Range on Protein: 164-361 Range on HMM: 1-267/359 Sequence Identity: 21% (58 aa) FNPENLIGKGGYADVYKGCLP----------------SGELVAVKRLTRGGKE----------------EQGTSFLTELGVLGHVS--HPNATPLLGFCV . ||||.. |||.. .||..|.|.. .. |. ..| |. .. . . ||| .| .. WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF DGG--------LFLVFHFLPHGSLAAMLH---GSRL-----------MEWPARFKAAIGTARG-LHYLHSNCRRRIIHRDIKSSNILLGPDFEPQITDFG ..| |... ... ||| ... | .. . . . . .| |.||||. |||||||..|||| ..||| KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDFG LAKWLPSEWT--------------H-HTVPVEGTFGYLAPEYFLHGI------VDEKTDVFAFGVLLLELVTGLRP ... | .. . .. . || . ||| . . |.| |. .| ...|..|| | VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPP |
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Kinase | LRR2_e.AA | Ciliate-E2 | 164-361 | 18 | 6.4e-24 | 78.99 | In-house | 1-295 (365) | Show / Hide |
Range on Protein: 164-361 Range on HMM: 1-295/365 Sequence Identity: 18% (58 aa) FNPENLIGKGGYADVYKGCL------------------------PSGELVAVKRLTRGGKEEQG--TSFL----------TELGVLGHVSHPNATPLLGF .. ..||.|....|||.. . ..|.|.. ..|.. . . |. .| ...||| . . YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC CV---DGGLFLVFHFLPHGSLAA--------------------MLHGSRLMEWPAR-FKAAIGTAR----------GLHYLHSNCRRRIIHRDIKSSNIL | ..||. .. .|.| . . ...|. .. || . .|.||||. . ||||||| .||| FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFK-----TKAEFYIACIILALEYLHSKNN--IIHRDIKPENIL LGPDFEPQITDFGLAK------------WLPSEWTHHTVPVEGTFG-------------------YLAPEYFLHGIVD---------EKTDVFAFGVLLL . . |.||||.| . ... . ..|.| |.||| . . | .| |....||.| F-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILY ELVTGLRP |...| .| EMLFGKPP |
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Kinase | LRR2_e.AA | Pkinase_Tyr | 164-309 | 27 | 1.1e-18 | 63.85 | Pfam | 1-159 (270) | Show / Hide |
Range on Protein: 164-309 Range on HMM: 1-159/270 Sequence Identity: 27% (45 aa) FNPENLIGKGGYADVYKGCLP-----SGELVAVKRLTRGGKEEQ--GTSFLTELGVLGHV-SHPNATPLLGFCV--DGG--LFLVFHFLPHGSLAAMLHG .|.| . .|||| . . |||| | | .|| .|. |. .. . .||| |.| |. .. ...|. . |||.| |. ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK ----SRLMEWPARFKAAIGTARGLHYLHSNCRRRIIHRDIKSSNILLGPDFEPQITDFGLAK . . . .. |.|. ||.|. .||||. |.|.. .. |.|||||. HREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLAR |
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Kinase | LRR2_e.AA | TyrKc | 164-427 | 22 | 1.5e-16 | 45.01 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 164-427 Range on HMM: 1-280/280 Sequence Identity: 22% (68 aa) FNPENLIGKGGYADVYKGCLPSGELVAVKRLTRGGKEEQGTSFLTELGVLGHV--SHPNATPLLGFCVD--------GGLFLVFHFLPHGSLAAMLHGSR . .| | . |||| . . |||| | . |. |. .. .. .||| |.| |.. . |..|. . |||.| |. .| ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR L-MEWPARFKAAIGTARGLHYLHSNCRRRIIHRDIKSSNILLGPDFEPQITDFGLAKWLPSE------WTHHTV----PVE--GTFGYLAPEYFLHGIVD .. . .. |.| ||||. ..||||. |.|.| .. |.||||.. . .. .. .||| . .|. PKLCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT EKTDVFAFGVLLLELVT-GLRPIDS-TQKSLVMKVRPLLESANIQQLVDGRLKGAYNL----------SEVQKTILAARLCIRQSAIARPCMADVSSYT .|.||..|||.. |. | | | .|. .|. . ..| .. .|. .|. . | . | . . ||..... .. TKSDVWSFGVCMWEIFTYGQQPYPGMIQQ--MMSNQEVIE-----YVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IM--KQCWHEDPEDRPTFSEIHECF |
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Kinase | LRR2_e.AA | Pkinase_Tyr | 329-361 | 44 | 0.001614 | 12.54 | Pfam | 181-214 (270) | Show / Hide |
Range on Protein: 329-361 Range on HMM: 181-214/270 Sequence Identity: 44% (15 aa) LAPEYFLHGIVDEKTDVFAFGVLLLELVT-GLRP .||| . .|. .|.|| .||||. |..| | | MAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQP |