LRR2_e

Species: S.moellendorffii
Alias: LRR2_e
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: LRR2

Sequence

Name Sequence Type Origin Length Description Download
LRR2_e.AA Protein None 448 None Fasta, JSON
LRR2_e.NA RNA None 1347 None Fasta, JSON
LRR2_e.kin_dom Protein Kinase Domain None 195 None Fasta, JSON

Protein domain

Protein domains of LRR2_e.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase LRR2_e.AA IRAK 164-364 34 5.5e-53 182.36 In-house 1-226 (317) Show / Hide
Range on Protein: 164-364
Range on HMM: 1-226/317
Sequence Identity: 34% (79 aa)

FNPENLIGKGGYADVYKGCLPSGE-LVAVKRLTRGGKEEQGTS---FLT---ELGVLGHVSHPNATPLLGFCVDGGLF-LVFHFLPHGSLAAMLHGSR--
|...|.||.||...||.| .   .  .|||.|  . . ... .   |..   || |.    |||  ||.|.| ... . ||. ..| ||| . |..    
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

--L--MEWPARFKAAIGTARGLHYLHSNC-RRRIIHRDIKSSNILLGPDFEPQITDFGLAKWL--PSEWTHHTV------PVEGTFGYLAPEYFL--HGI
  .   .|. |.. ..|||.|...||.|     |||.||||.||||  .|.| |.||||.      |.  ..|.       | ||  |..||.     |.
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQ

VDEKTDVFAFGVLLLELVTGLRPIDS
   ||||. ||. |||..||.|. ..
LTKKTDVYSFGIVLLEVLTGCRAVYD

Kinase LRR2_e.AA TKL 170-361 23 1.3e-45 157.9 In-house 1-288 (364) Show / Hide
Range on Protein: 170-361
Range on HMM: 1-288/364
Sequence Identity: 23% (70 aa)

IGKGGYADVYKGCLPS---------GELVAVKRLTRGG-KEEQGTS-------------------------FLTELGVLGHVSHPNATPLLGFCVDGG--
||.||.. |||| .           |. ||||.. .   .|.  .|                         .  |. ..   .|||  ...|.| ...  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------LFLVFHFLPHGSLAAMLHGSRLMEWPARFKAAIGTARGLHYLHSNCR-----RRIIHRDIKSSNILLGPDFE--------------PQ
            |..|  . |.|||   ||      |. |.. |...|||..||||.       . |||||.||.|||.  ...              . 
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCK

ITDFGLAKWL-----PSEWTHH------------TVPVEG-TFGYLAPEYFL----------------HGIVDEKTDVFAFGVLLLELVTGLRP
|.||||....      . . ..            |   .. |....||| .                 ..  .||.||..||..| |..|. ||
ICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRP

Kinase LRR2_e.AA Pkinase 164-358 24 1.1e-38 137.93 Pfam 1-208 (293) Show / Hide
Range on Protein: 164-358
Range on HMM: 1-208/293
Sequence Identity: 24% (53 aa)

FNPENLIGKGGYADVYKGCLPSGEL-VAVKRLTRGGKEE--QGTSFL-TELGVLGHVSHPNATPLLGFCV-DGGLFLVFHFLPHG----SLAAMLH--GS
.  .  ||.|... |||..  . .  ||||.. . ....  . | .. .|. .. ...|||   |....  .. . .|. ....|    .|.....   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

RLM--EWPARFKAAIGTARGLHYLHSNCRRRIIHRDIKSSNILLGPDFEP----QITDFGLAK---WLPSEWTHHTVPVEGTFGYLAPEYFL-HGIVDEK
. .  ..    . .  ..||| |.||.   .|||||.|..|||.  . ..     |.||||||   . ... ...   . || .|.|||  . .   . |
GCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTT---FCGTPWYMAPEVIRGGQYYGPK

TDVFAFGVLLLELVTG
 |....|..| |...|
VDMWSCGCILYEMLCG

Kinase LRR2_e.AA MLK 164-358 27 3e-31 105.71 In-house 1-232 (291) Show / Hide
Range on Protein: 164-358
Range on HMM: 1-232/291
Sequence Identity: 27% (66 aa)

FNPENLIGKGGYADVYKGCLPSGEL-----VAVKRLTRGG-----KEEQGTSFLTELGVLGHVSHPN----ATPLLGFCVD-GG-LFLVFHFLPHGSLAA
.. .  ||.|.. .|.||    ...     ||||| .        ....   | .|   | ..||||      ...| | . .  ...| .....|||. 
IQFHEWIGSGSFGKVWKGRW-RNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

MLHGSRL--------------MEWPARFKAAIGTARGLHYLHSNCRRRIIHRDIKSSNILLGP------DFEPQITDFGLAKWLPSEWTHH---TVPVEG
 ||| |               .     .. |   |||.|||||. .  |||||.||.|||.        .    |.|||...    .|...        |
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSR----DWHQMCTNMMSNAG

TFGYLAPEYF---LHGIVDEKTDVFAFGVLLLELVTG
|. . ||| .    .. ..|| ||. .||.| |..|.
TYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTR

Kinase LRR2_e.AA TK 164-357 16 9.7e-30 96.27 In-house 1-389 (486) Show / Hide
Range on Protein: 164-357
Range on HMM: 1-389/486
Sequence Identity: 16% (63 aa)

FNPENLIGKGGYA---DVYKGCLPSG--------------------------ELVAVKRLTRGGKEEQGT----------------SFLTELGVLGH--V
   .. .|.| .    .|||| . ..                          . |||| |. |  ..|                  ... |. .. |   
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

SHPNATPLLGFCVDGG-------------LFLVFHFLPHGS----LAAMLHGSRL---------------------------------------------
 |||   |.| |..|.             . .|  . |||.    |   |. .|                                              
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------MEWPARFKAAIGTARGLHYLHSN----CRRRIIHRDIKSSNILLGPDFE-----------PQITDFG--
                               .  . .   .   |.|. ||||.       ...|||.   |.|.| .               |.|||  
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

------LAKWLPSEWTHHTVPVEGTFG-------------------------YLAPEYFL---------HGIVDEKTDVFAFGVLLLELVT
      ||. ..|.   ...  .|| .                         ..||| ..         .|.  .|.||..||||. |..|
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFT

Kinase LRR2_e.AA LRRK 164-363 24 6.6e-29 99.38 In-house 1-284 (351) Show / Hide
Range on Protein: 164-363
Range on HMM: 1-284/351
Sequence Identity: 24% (71 aa)

FNPENLIGKGGYA-DVYKGCLPS---------------------------GELVAVKRLTRGG------------------------------KEEQGTS
.  |..||.||..  ||.. . .                           .. ||.| ..|..                               |.  ..
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

FLT---ELGVLGHVSHPNATPLLGFCVDGGLFLVFHFLPHGSLAAMLH---GSRL------MEWPARFKAAIGTARGLHYLHSNCRRR--IIHRDIKSSN
| .   |. .. |  |||  .|.||| .  | .|  ..|||.|   ||    ...      . |  . | |.  |.|. ||||.   .  ||||| || |
FREFRHEVWIMSHLNHPNIVSLKGFCIH-PLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSH---NPPIIHRDLKSPN

ILLGPDFEPQ------------ITDFGLAKWLPSEWTHH--TVPVEGTFGYLAPEYFLHG---IVDEKTDVFAFGVLLLELVTGL-RPID
|||    ...            | |||.   .    .|.  .  ..|..|..|||    .     .||.|...||..| ||.|.. .| |
ILLWSSPQNHSPNYPNAHVCAKIADFGISR-MF-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFD

Kinase LRR2_e.AA Dicty4-Unclassified 167-358 31 3.8e-27 89.99 In-house 4-204 (263) Show / Hide
Range on Protein: 167-358
Range on HMM: 4-204/263
Sequence Identity: 31% (65 aa)

ENLIGKGGYADVYKGCLPSGELVAVKRLTRGG---KEEQGTSFLTELGVLGHVSHPNATPLLGFCVDG-----GLFLVFHFLPHGSLAAMLH-----GSR
   ||||  . |.||    |  |||| .  .     ||    |. |  .|| ..|||   . | |.        .  |  |.. | |  . |       .
DQFIGKGHFSKVHKGNW-KGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQ

LMEWPA--RFKAAIGTARGLHYLHSNCRRRIIHRDIKSSNILLGPDFEPQITDFGLAKWLPSEWTHHTVPVEGTFGYLAPEYFLHGIVDEKTDVFAFGVL
 .        | |.  |.|. .||.   | .|||||||||||.  .|   | |||..       .  |.   ||    .||   |     | ||. ....
PIKLDDTLIIKYAFDIAQGMQHLHT---RNFIHRDIKSSNILMDKHFNIKIADFGISRVIDFNFNMTTIA--GTPKWESPECLMHESYNQKSDVYSYAMM

LLELVTG
| ||.||
LYELATG

Kinase LRR2_e.AA Dicty4 164-361 32 6.2e-27 87.0 In-house 1-216 (277) Show / Hide
Range on Protein: 164-361
Range on HMM: 1-216/277
Sequence Identity: 32% (71 aa)

FNPENLIGKGGYADVYKGCLPSGELVAVKRL--TRGG-KEEQGTSFLTELGVLGHVSHPNATPLLGFCV-----DGGLFLVFHFLPHGSLAAMLHG----
 | |..||||... ||||    |  |||| |  .  .  |.  ..|. |   ..  .|||   ..| |       | .  |  ..| |.|.  ||     
INIEQRIGKGSFGEVYKGTW-RGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSE

---SRLMEWPARFK---AAIGTARGLHYLHS-NCRRRIIHRDIKSSNILLGPDFEPQITDFGLAKWLPSEWTHHT--VPVEGTFGYLAPEYFLHGIVDEK
   |  ..|| . .    |. .|||. .||. |.  .|||||.||.|.|   ..   ..||||..    . .| .    . || .. |||   |   .||
QQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNP--VIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEK

TDVFAFGVLLLELVTGLRP
 ||. || .| |..|.  |
ADVYSFGIVLWEILTRQEP

Kinase LRR2_e.AA TKL-Unique 166-361 29 6.5e-27 92.04 In-house 1-233 (290) Show / Hide
Range on Protein: 166-361
Range on HMM: 1-233/290
Sequence Identity: 29% (70 aa)

PENLIGKGGYADVYKGCLPSGELVAVKRLTRGGKEEQGTS----FLTELGVLGHVS-HPNATPLLGFCVD-----GGLFLVFHFLPHGSLAAMLH-----
. |.|| |||. ||||  . |. ||.|..    .|..  .    |  |. ..     ||| . . |.|.|     . ...|  ..|.|||   ||     
FWNKIGEGGYGQVYKGKWR-GYPVAIKQFHP--NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNN

-----GSRLMEWPARFKAAIGTARGLHYLHSNCRRRIIHRDIKSSNILLGPD-----FEPQITDFGLAKWLPSEWTHHTV--------PVEGTFGYLAPE
      .  . .  | | ||  |.|..|||..    |||||.||||.|.  .     .  .| ||||.| . .. .  .          ..|.| ..|||
NNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPE

YFLH--GIVDEKTDVFAFGVLLLELVTGLR------P
 .       .|| ||..||. | |..|. .      |
VLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKP

Kinase LRR2_e.AA S_TKc 164-432 23 7.9e-26 93.04 SMART 1-231 (231) Show / Hide
Range on Protein: 164-432
Range on HMM: 1-231/231
Sequence Identity: 23% (67 aa)

FNPENLIGKGGYADVYKGCLPS-GELVAVKRLTRGGKEEQGTSFLTELGVLGHVSHPNATPLLGFCVDGGLFLVFHFLPH--GSLAAMLHGSR-------
.   ..||||... |||.   . |..||.|..          ... |. .| .  |||   |.....|. |..|. ....  |.|  ...  .       
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LMEWPARFKAAIGTARGLHYLHSNCRRRIIHRDIKSSNILLGPDFEPQITDFGLAKWLPSEWTHHTVPVEGTFGYLAPEYFLHGIVDE-KTDVFAFGVLL
. |  ||| ..  ....| |.||   ..|||||.| .||||    .  |.|||||. |          . ||  |.||| .     .  | |. ..|..|
FPE-HARFYMY-QICCALEYCHS---HGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCIL

LELVTGLRPIDSTQKSLVMKVRPLLESANIQQLVDGRLKGAYNLSEVQKTILAARLCIRQSAIARPCMADVSSYTL----SPGF
 |...|  | . ... .  |..                         .  .   | | .     ||   ..  . .     | |
YEMLCGYPPFP-QMQMMFKKIG------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase LRR2_e.AA STE 164-361 21 1.5e-25 87.28 In-house 1-267 (359) Show / Hide
Range on Protein: 164-361
Range on HMM: 1-267/359
Sequence Identity: 21% (58 aa)

FNPENLIGKGGYADVYKGCLP----------------SGELVAVKRLTRGGKE----------------EQGTSFLTELGVLGHVS--HPNATPLLGFCV
.     ||||..  |||..                  .||..|.|..    ..                |.  ..| |. .. . .  |||    .| ..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DGG--------LFLVFHFLPHGSLAAMLH---GSRL-----------MEWPARFKAAIGTARG-LHYLHSNCRRRIIHRDIKSSNILLGPDFEPQITDFG
..|        |...  ... |||  ...   |              .. .   . .  . .| |.||||.    |||||||..||||       ..|||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDFG

LAKWLPSEWT--------------H-HTVPVEGTFGYLAPEYFLHGI------VDEKTDVFAFGVLLLELVTGLRP
... | .. .                ..  . ||  . |||  . .        |.| |.  .| ...|..||  |
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPP

Kinase LRR2_e.AA Ciliate-E2 164-361 18 6.4e-24 78.99 In-house 1-295 (365) Show / Hide
Range on Protein: 164-361
Range on HMM: 1-295/365
Sequence Identity: 18% (58 aa)

FNPENLIGKGGYADVYKGCL------------------------PSGELVAVKRLTRGGKEEQG--TSFL----------TELGVLGHVSHPNATPLLGF
..  ..||.|....|||..                           . ..|.|..   ..|..    . .           |. .| ...|||   .  .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

CV---DGGLFLVFHFLPHGSLAA--------------------MLHGSRLMEWPAR-FKAAIGTAR----------GLHYLHSNCRRRIIHRDIKSSNIL
     |  ..||. .. .|.|                      . . ...|.  .. ||      .          .|.||||. .  ||||||| .|||
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFK-----TKAEFYIACIILALEYLHSKNN--IIHRDIKPENIL

LGPDFEPQITDFGLAK------------WLPSEWTHHTVPVEGTFG-------------------YLAPEYFLHGIVD---------EKTDVFAFGVLLL
.     . |.||||.|             .  ...   .  ..|.|                   |.||| .  .  |         .| |....||.| 
F-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILY

ELVTGLRP
|...| .|
EMLFGKPP

Kinase LRR2_e.AA Pkinase_Tyr 164-309 27 1.1e-18 63.85 Pfam 1-159 (270) Show / Hide
Range on Protein: 164-309
Range on HMM: 1-159/270
Sequence Identity: 27% (45 aa)

FNPENLIGKGGYADVYKGCLP-----SGELVAVKRLTRGGKEEQ--GTSFLTELGVLGHV-SHPNATPLLGFCV--DGG--LFLVFHFLPHGSLAAMLHG
      .|.| . .|||| .       .  |||| |  |  .||    .|. |. .. .  .|||   |.| |.  ..   ...|. . |||.|   |. 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

----SRLMEWPARFKAAIGTARGLHYLHSNCRRRIIHRDIKSSNILLGPDFEPQITDFGLAK
     .    .   . ..  |.|. ||.|.    .||||.   |.|.. ..   |.|||||.
HREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLAR

Kinase LRR2_e.AA TyrKc 164-427 22 1.5e-16 45.01 SMART 1-280 (280) Show / Hide
Range on Protein: 164-427
Range on HMM: 1-280/280
Sequence Identity: 22% (68 aa)

FNPENLIGKGGYADVYKGCLPSGELVAVKRLTRGGKEEQGTSFLTELGVLGHV--SHPNATPLLGFCVD--------GGLFLVFHFLPHGSLAAMLHGSR
   .  .| | .  |||| .   . |||| |  .        |. |. .. ..  .|||   |.| |..        . |..|. . |||.|   |. .|
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

L-MEWPARFKAAIGTARGLHYLHSNCRRRIIHRDIKSSNILLGPDFEPQITDFGLAKWLPSE------WTHHTV----PVE--GTFGYLAPEYFLHGIVD
    ..   . ..  |.|  ||||.   ..||||.   |.|.| ..   |.||||.. . ..          ..              .||| . .|.  
PKLCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

EKTDVFAFGVLLLELVT-GLRPIDS-TQKSLVMKVRPLLESANIQQLVDGRLKGAYNL----------SEVQKTILAARLCIRQSAIARPCMADVSSYT
.|.||..|||.. |. | |  |    .|.  .|. . ..|     .. .|.                 .|. . |   . | .  .  ||..... .. 
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQ--MMSNQEVIE-----YVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IM--KQCWHEDPEDRPTFSEIHECF

Kinase LRR2_e.AA Pkinase_Tyr 329-361 44 0.001614 12.54 Pfam 181-214 (270) Show / Hide
Range on Protein: 329-361
Range on HMM: 181-214/270
Sequence Identity: 44% (15 aa)

LAPEYFLHGIVDEKTDVFAFGVLLLELVT-GLRP
.||| . .|.  .|.|| .||||. |..| |  |
MAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQP