LRR36_d

Species: S.moellendorffii
Alias: LRR36_d
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: LRR36

Sequence

Name Sequence Type Origin Length Description Download
LRR36_d.AA Protein None 934 None Fasta, JSON
LRR36_d.NA RNA None 2805 None Fasta, JSON
LRR36_d.kin_dom Protein Kinase Domain None 146 None Fasta, JSON

Protein domain

Protein domains of LRR36_d.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LRRNT_2 LRR36_d.AA LRRNT_2 31-64 22 0.00044 16.16 Pfam 5-46 (46) Show / Hide
Range on Protein: 31-64
Range on HMM: 5-46/46
Sequence Identity: 22% (10 aa)

VAALQLLFKNWQS-TH-----LNWT----DYDPCGSSWRGVVCN
..||. . . ... ..     ..|.    | |.|   |.|| |.
GQALLAFKSSLNDSDPHHGVLSSWNPSSSDSDCCS--WTGVTCD

LRR_1 LRR36_d.AA LRR_1 93-116 44 0.000688 17.96 Pfam 1-26 (26) Show / Hide
Range on Protein: 93-116
Range on HMM: 1-26/26
Sequence Identity: 44% (12 aa)

DLVALDLSF-N-PQLTGEIPKE-LGRL
 |  ||||  | ..|||.||.. .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_1 LRR36_d.AA LRR_1 118-140 40 0.001857 16.43 Pfam 1-26 (26) Show / Hide
Range on Protein: 118-140
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

NLQYLSLQGC---NFYGSVPKE-LGLL
|||.|.|.||   |. |..|.. .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_1 LRR36_d.AA LRR_1 142-164 33 0.953025 6.82 Pfam 1-26 (26) Show / Hide
Range on Protein: 142-164
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

NMKFFALNM-N--KLTGSIPPE-LGGF
| .   |.  |  .|||.|||. . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_1 LRR36_d.AA LRR_1 166-190 28 16.585777 2.42 Pfam 1-26 (26) Show / Hide
Range on Protein: 166-190
Range on HMM: 1-26/26
Sequence Identity: 28% (8 aa)

NVTWFDIAQ-N--GLTGPLPVSTSVPQN
| .  |.   |   ||| .| | .  . 
NLQHLDLSGCNCCNLTGHIPPS-CF-NL

LRR_1 LRR36_d.AA LRR_1 198-220 22 0.067368 10.9 Pfam 1-26 (26) Show / Hide
Range on Protein: 198-220
Range on HMM: 1-26/26
Sequence Identity: 22% (6 aa)

SVVHIHLFN-N--SISGSLPKE-LATL
.  |..| . |  ...|..|.. .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_1 LRR36_d.AA LRR_1 222-244 37 0.17162 9.46 Pfam 1-26 (26) Show / Hide
Range on Protein: 222-244
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

FLRHLMVEN-N--ALTGEIPVE-YGNF
 |.|| . . |   |||.|| .   |.
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_1 LRR36_d.AA LRR_1 246-268 22 0.200565 9.22 Pfam 1-26 (26) Show / Hide
Range on Protein: 246-268
Range on HMM: 1-26/26
Sequence Identity: 22% (6 aa)

ALEILRVDN-N--RVQGTIPAT-INQI
 |..| ... |  ...|.||   . . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_1 LRR36_d.AA LRR_1 270-291 33 0.001894 16.4 Pfam 1-26 (26) Show / Hide
Range on Protein: 270-291
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

KLLELHLAN-N--SLVGTLPD--FSAL
.| .|.| . |  .|.|..|.  | .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_1 LRR36_d.AA LRR_1 318-340 33 1.812571 5.83 Pfam 1-26 (26) Show / Hide
Range on Protein: 318-340
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

NLQTLKIDK-G--FLNGTIPDG-LFAL
|||.| ..      | |.||.. . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_1 LRR36_d.AA LRR_1 342-366 27 0.161878 9.55 Pfam 1-26 (26) Show / Hide
Range on Protein: 342-366
Range on HMM: 1-26/26
Sequence Identity: 27% (8 aa)

ALESVSLSN-N--QLSGTVTFPST-VKRL
 |.. .||. |  .|.|.  .|.     |
NLQHLDLSGCNCCNLTGH--IPPSCF-NL

Kinase LRR36_d.AA IRAK 645-788 36 4.3e-50 172.74 In-house 1-159 (317) Show / Hide
Range on Protein: 645-788
Range on HMM: 1-159/317
Sequence Identity: 36% (58 aa)

FSSANEIGSGGYGKVYKGVLVTGEE--VAIK--KAEEGSMQGSGE--FKT---EIELLSRVHHRNLVGLIGFSYEQGSQMLVYEYMASGSLRDHLANSRH
|. .| ||.||.| ||.|... ...  .|.|  |... . ... .  | .   |.....| .| |.| | |...| .   |||.||. |||.| |.    
FHKDNRIGEGGFGCVYRGQWK-NTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDG

------LSWNKRVEIALDSAKGLAYLHELASP-SIIHRDIKSGNILLDENLKAKVADFGL
      ||| .|..|.. .|.|. .||.. .  .|||.|||| |||||... .| .||||
QCPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGL

Kinase LRR36_d.AA TKL 651-788 28 1.1e-48 168.08 In-house 1-200 (364) Show / Hide
Range on Protein: 651-788
Range on HMM: 1-200/364
Sequence Identity: 28% (59 aa)

IGSGGYGKVYKGVLVT---------GEEVAIKKAEEGSMQGSGE---------------------------FKTEIELLSRVHHRNLVGLIGFSYEQGS-
|||||.|.||||..           |..||.||  . ... . .                           .. || ..|| .| |.| ..|.. . .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------QMLVYEYMASGSLRDHLANSRHLSWNKRVEIALDSAKGLAYLHELAS-----PSIIHRDIKSGNILLDENLK--------------AK
             ..|.||.  |||...|       |..|. .||| |.|..|||         | |||||.|| |||.|||..              .|
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCK

VADFGL
..||||
ICDFGL

Kinase LRR36_d.AA LISK 650-788 37 4.4e-46 147.6 In-house 1-151 (296) Show / Hide
Range on Protein: 650-788
Range on HMM: 1-151/296
Sequence Identity: 37% (58 aa)

EIGSGGYGKVYKGVLV-TGEEVAIKKAEE-----GSMQGSGEFKTEIELLSRVHHRNLVGLIGFSYE-QGSQMLVYEYMASGSLRDHLANSR----HLSW
|||.|..|||||| .  ||...|||. ..             .. |.... .  |.| |  .| .|. .|. ..| ||.  | |.. |...     .|.|
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW

NKRVEIALDSAKGLAYLHELASPSIIHRDIKSGNILLDEN----LKAKVADFGL
 .|| |||| |.|..|||   |  ||||| || |.|..||     ..||.|||.
PQRVKIALDIACGMSYLH---SMNIIHRDLKSKNCLVRENDNNQWRIKVCDFGF

Kinase LRR36_d.AA TKL-Unique 647-788 36 3e-41 143.26 In-house 1-163 (290) Show / Hide
Range on Protein: 647-788
Range on HMM: 1-163/290
Sequence Identity: 36% (61 aa)

SANEIGSGGYGKVYKGVLVTGEEVAIKKAEE---GSMQGSGEFKTEIELLSRVH-HRNLVGLIGFSY----EQGSQMLVYEYMASGSLRDHLA-------
  | ||.||||.||||.   |..||||. ..    | . . ||. |. .... | | |.| ..|..      ..   .| ||.  |||.|.|.       
FWNKIGEGGYGQVYKGKW-RGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

---NSRHLSWNKRVEIALDSAKGLAYLHELASPSIIHRDIKSGNILLDEN-----LKAKVADFGL
   |.  |....|| .|.| |.|. ||| .  | |||||.|| |.|.|.|     ...|..||||
NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGL

Kinase LRR36_d.AA MLK 645-788 27 6e-39 132.78 In-house 1-179 (291) Show / Hide
Range on Protein: 645-788
Range on HMM: 1-179/291
Sequence Identity: 27% (50 aa)

FSSANEIGSGGYGKVYKGVLVTGEE-----VAIKKAE---EGSMQG----SGEFKTEIELLSRVHHRN----LVGLIGFSYEQGSQ-MLVYEYMASGSLR
.     ||||..|||.||.   ...     ||.|...   . ...     . .|..|...|... |.|     . . | . .....  .| ||.. ||| 
IQFHEWIGSGSFGKVWKGRW-RNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLY

DHLANSRH--------------LSWNKRVEIALDSAKGLAYLHELASPSIIHRDIKSGNILLDE------NLKAKVADFGL
. |.. |                .    . .||. |.|..|||..| . |||||.|| |||.||      ....|..|||.
NVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGT

Kinase LRR36_d.AA Pkinase_Tyr 645-788 30 1.2e-38 131.46 Pfam 1-157 (270) Show / Hide
Range on Protein: 645-788
Range on HMM: 1-157/270
Sequence Identity: 30% (49 aa)

FSSANEIGSGGYGKVYKGVLV-----TGEEVAIKKAEEGSMQG---SGEFKTEIELLSRV-HHRNLVGLIGFSY-EQGS--QMLVYEYMASGSLRDHLAN
 .   ..|.| .|.||||..      |. .||.|.  ||.|.    . .|  |.....   || |.| |.|  . ....   ..| |||. |.|.|.| .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

----SRHLSWNKRVEIALDSAKGLAYLHELASPSIIHRDIKSGNILLDENLKAKVADFGL
     ..|.    ...... |||..||..     .||||.   |.|..||...|..||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGL

Kinase LRR36_d.AA Dicty4 645-788 33 3.7e-34 111.45 In-house 1-160 (277) Show / Hide
Range on Protein: 645-788
Range on HMM: 1-160/277
Sequence Identity: 33% (56 aa)

FSSANEIGSGGYGKVYKGVLVTGEEVAIKKA-----E--EGSMQGSGEFKTEIELLSRVHHRNLVGLIGFSY----EQGSQMLVYEYMASGSLRDHLAN-
    ..||.|..|.||||  . | |||.||.        |  ..   ||. |.....   | |.. . | .     . |. . | ||| .|.|   | . 
INIEQRIGKGSFGEVYKGT-WRGKEVAVKKLNNHNQNFDENMLN---EFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDK

------SRHLSWNKRVE---IALDSAKGLAYLHELASPSIIHRDIKSGNILLDENLKAKVADFGL
      |  |.|  .     .|.| |.|...||.   | |||||.|| |.| |.|...||.||||
PSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHC-CNPVIIHRDLKSHNLLVDKNWRVKVCDFGL

Kinase LRR36_d.AA TK 645-788 17 2.3e-33 108.65 In-house 1-297 (486) Show / Hide
Range on Protein: 645-788
Range on HMM: 1-297/486
Sequence Identity: 17% (52 aa)

FSSANEIGSGGYG---KVYKGVLVTG--------------------------EEVAIKKAEEGSMQGSGEFKT-----------------EIELLS--RV
    ...|.| .|   .|||| . ..                          ..||.|   ||. . . ||.                  |.....    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

HHRNLVGLIG-------------FSYEQGSQMLVYEYMASGS----LRDHLANSRH--------------------------------------------
|| |.| |.|             .  .|.  |.| |||. |.    |||.| ..|.                                            
HHPNIVRLYGVCTQGEPKPCFEVV-VHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQD

--------------------------------LSWNKRVEIALDSAKGLAYLHEL----ASPSIIHRDIKSGNILLDENLK-----------AKVADFGL
                                |.   .. .... |.|..|||..      . ..|||.   |.|..||..           .|.|||||
YDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGL





Kinase LRR36_d.AA Pkinase 645-805 28 7.2e-33 117.3 Pfam 1-175 (293) Show / Hide
Range on Protein: 645-805
Range on HMM: 1-175/293
Sequence Identity: 28% (51 aa)

FSSANEIGSGGYGKVYKGVLVTGEE-VAIKKAEEGSMQGSGEFKT-----EIELLSRVHHRNLVGLIGFSYEQGSQMLVYEYMASG----SLRDHLA--N
.     ||||..|.|||.. .  .. ||.|. .    . |.. .|     ||... |..| | | |... .. ..  .| ||.  |    .| |..   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

SRHL--SWNKRVEIALDSAKGLAYLHELASPSIIHRDIKSGNILLDENLKA----KVADFGLGKE--DRAHASITQVKGTL
.. .  |..    ...  ..||.|.|.    .|||||.|. |||.|.|       |..|||| |          | . ||.
HGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTP

Kinase LRR36_d.AA LRRK 645-788 25 3.8e-30 103.85 In-house 1-224 (351) Show / Hide
Range on Protein: 645-788
Range on HMM: 1-224/351
Sequence Identity: 25% (59 aa)

FSSANEIGSGGYG-KVYKGVLVT---------------------------GEEVAIKKAEEG----------------------------------SMQG
. . ..||.||.| .||.. .                             ...||||| . .                                  ..  
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

SGEFKTEIELLSRVHHRNLVGLIGFSYEQGSQMLVYEYMASGSLRDHLANSR---------HLSWNKRVEIALDSAKGLAYLHELASPSIIHRDIKSGNI
  ||  |. ..|. .| |.| |.||. .    ..| ||.  |.| ..| |..         |.||. . .|||. |||..|||  ..|.||||| || ||
FREFRHEVWIMSHLNHPNIVSLKGFCIHP--LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHS-HNPPIIHRDLKSPNI

LL---D---------ENLKAKVADFGL
||   .         .. .||.||||.
LLWSSPQNHSPNYPNAHVCAKIADFGI

Kinase LRR36_d.AA Dicty4-Unclassified 648-804 30 4.8e-29 96.58 In-house 4-171 (263) Show / Hide
Range on Protein: 648-804
Range on HMM: 4-171/263
Sequence Identity: 30% (53 aa)

ANEIGSGGYGKVYKGVLVTGEEVAIKKAEEGSMQGS----GEFKTEIELLSRVHHRNLVGLIGFSYEQ----GSQMLVYEYMASGSLRDHLA-----NSR
  .|| |   ||.||.   | .||.||  |.. .       .|| |.|.|  . | ||| . | .          . | | | .| |            .
DQFIGKGHFSKVHKGNW-KGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQ

HLSWNK--RVEIALDSAKGLAYLHELASPSIIHRDIKSGNILLDENLKAKVADFGLGKEDRAHASITQVKGT
 .. .    . .|.| |.|...||   .  .||||||| |||.| .  .|.||||.  .       | . ||
PIKLDDTLIIKYAFDIAQGMQHLH---TRNFIHRDIKSSNILMDKHFNIKIADFGISRVIDFNFNMTTIAGT

Kinase LRR36_d.AA LISK-DD1 689-788 34 4.9e-22 76.61 In-house 44-173 (290) Show / Hide
Range on Protein: 689-788
Range on HMM: 44-173/290
Sequence Identity: 34% (46 aa)

EIELLSR---VHHRNLVGLIGFSYE-------------QGSQMLVYEYMASGSLRDHLAN-------------SRHLSWNKRVEIALDSAKGLAYLHELA
||. |       | |.|  || ...              .| ..| |..  | |.. | |             . ...| .|| |||| |.. ||||   
EIKMLKNLLNIRHPNIVQFIGICEHPLASPSLVNRLLNESSLYIVTEFIEGGDLHWYLKNTPFDDTPEQYIHHKIPIPWKLRVKIALDIACAMAYLH---

SPSIIHRDIKSGNILLDEN----LKAKVADFGL
| .||||| || |||.|||     ..|| |||.
SKNIIHRDLKSKNILVDENGDSQWRIKVCDFGF

Kinase LRR36_d.AA TyrKc 645-867 20 8e-17 49.32 SMART 1-280 (280) Show / Hide
Range on Protein: 645-867
Range on HMM: 1-280/280
Sequence Identity: 20% (58 aa)

FSSANEIGSGGYGKVYKGVLVTGEEVAIKKAEEGSMQGSGEFKTEIELLSRV--HHRNLVGLIGFSYEQ-------GSQMLVYEYMASGSLRDHLANSRH
 .   ..|.| .|.||||..   ..||.|.  |..     .|  |.......  || |.| |.|   .|       .  |.| |||. |.|.|.| ..|.
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

-LSWNKRVEIALDSAKGLAYLHELASPSIIHRDIKSGNILLDENLKAKVADFGLGKEDRAH------ASITQVKGTLVSK-------------NFLLFSC
 |.. . ...... |.| .|||.     .||||.   |.|..||. .|..|||| ..   .       .   .|..  .|             |.  |. 
KLCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

LC------------FVLIALFHTG-----IHRSRVLHDAAAH-REERRLQ-----------------LRCGALGASN-SAAADLSREI
              | . .  . |     .  ..|...  .  | ..                    ..| .  ...    ... ...
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF

Kinase LRR36_d.AA S_TKc 645-924 17 3.1e-15 46.54 SMART 1-231 (231) Show / Hide
Range on Protein: 645-924
Range on HMM: 1-231/231
Sequence Identity: 17% (56 aa)

FSSANEIGSGGYGKVYKGVLVT-GEEVAIKKAEEGSMQGSGEFKTEIELLSRVHHRNLVGLIGFSYEQGSQMLVYEYMAS--GSLRDHLANSRH------
.   ..||.|..|||||.. .  |..||||.           .. ||..|.. || |.| |... .. ..  .| ||.    |.|.|.. . ..      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LSWNKRVEIALDSAKGLAYLHELASPSIIHRDIKSGNILLDENLKAKVADFGLGKEDRAHASITQVKGT-------LVSKNFLLFSC----------LCF
..      ..   ...|.|.|..    |||||.|  ||||||    |..|||| ..       | . ||       ..      ...          . .
FPE-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL-----GYGKCKCDWWSCGCILY

VLIA---LFHTGIHRSRVLHDAAAHREERRLQLRCGALGASNSAAADLSREIHRERGENSSGQGWLDGSRSFTGSQPGERSTERSHQVCGLGT--PVRRR
 ...   .|.   .  ....                                                            | |  . .... .  | .| 
EMLCGYPPFP---QMQMMFKKIG---------------------------------------------------------SPEAKDFIRKCLQKDPEKRP

GGGQQAK-------HGPS
.  .  .       |   
TA-EALQDEWDIKCHPWF

Kinase LRR36_d.AA LISK-DD1 650-674 64 3.3e-08 26.04 In-house 1-24 (290) Show / Hide
Range on Protein: 650-674
Range on HMM: 1-24/290
Sequence Identity: 64% (16 aa)

EIGSGGYGKVYKGVLVTGEEVAIKK
|||.|..||||||..  | .|||||
EIGKGSFGKVYKGCYF-GTPVAIKK